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Conserved domains on  [gi|1191363559|gb|OTE04287|]
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50S ribosome-binding GTPase [Escherichia coli]

Protein Classification

GTPase family protein( domain architecture ID 11466459)

GTPase family protein with a Ras-like GTPase domain, similar to Escherichia coli uncharacterized proteins YkfA, YeeP and YfjP

Gene Ontology:  GO:0005525|GO:0003924
PubMed:  11152757

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YeeP COG3596
Predicted GTPase [General function prediction only];
1-281 4.04e-72

Predicted GTPase [General function prediction only];


:

Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 224.65  E-value: 4.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559   1 MNPS-DAIEAIEKPLSSLPYSLSRHILEHLR--KLTSHEPVIGIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVRRF 77
Cdd:COG3596     1 MSTEvSSLTERLEALKRLPQVLRELLAEALErlLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGVGRPCTREIQRY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  78 RL-SGHGHSMVITDLPGVGESRDRDAEYEAlYRDILPELDLVLWLIKADDRALSVDEYFWRYILHRGHQ-QVLFVVTQAD 155
Cdd:COG3596    81 RLeSDGLPGLVLLDTPGLGEVNERDREYRE-LRELLPEADLILWVVKADDRALATDEEFLQALRAQYPDpPVLVVLTQVD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 156 KTEPCHEWDMAGIQPSPAQAQNIREKTEAVFRLF----RPVHPVVAVSARTGWELDTLVSALMTALPDHAASPLMTRLqd 231
Cdd:COG3596   160 RLEPEREWDPPYNWPSPPKEQNIRRALEAIAEQLgvpiDRVIPVSAAEDRTGYGLEELVDALAEALPEAKRSRLARLL-- 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1191363559 232 elrtesvRAQAREQFTGAVDRIFDTAESVCVAsvARTVLRAVRDTVVSVA 281
Cdd:COG3596   238 -------RAKAIDRYTLLAAAAALLAAALLAL--LALLLAALAAAPVALA 278
 
Name Accession Description Interval E-value
YeeP COG3596
Predicted GTPase [General function prediction only];
1-281 4.04e-72

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 224.65  E-value: 4.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559   1 MNPS-DAIEAIEKPLSSLPYSLSRHILEHLR--KLTSHEPVIGIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVRRF 77
Cdd:COG3596     1 MSTEvSSLTERLEALKRLPQVLRELLAEALErlLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGVGRPCTREIQRY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  78 RL-SGHGHSMVITDLPGVGESRDRDAEYEAlYRDILPELDLVLWLIKADDRALSVDEYFWRYILHRGHQ-QVLFVVTQAD 155
Cdd:COG3596    81 RLeSDGLPGLVLLDTPGLGEVNERDREYRE-LRELLPEADLILWVVKADDRALATDEEFLQALRAQYPDpPVLVVLTQVD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 156 KTEPCHEWDMAGIQPSPAQAQNIREKTEAVFRLF----RPVHPVVAVSARTGWELDTLVSALMTALPDHAASPLMTRLqd 231
Cdd:COG3596   160 RLEPEREWDPPYNWPSPPKEQNIRRALEAIAEQLgvpiDRVIPVSAAEDRTGYGLEELVDALAEALPEAKRSRLARLL-- 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1191363559 232 elrtesvRAQAREQFTGAVDRIFDTAESVCVAsvARTVLRAVRDTVVSVA 281
Cdd:COG3596   238 -------RAKAIDRYTLLAAAAALLAAALLAL--LALLLAALAAAPVALA 278
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
40-217 2.70e-61

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 190.63  E-value: 2.70e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  40 GIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVRRFRLSGHGHSMVITDLPGVGESRDRDAEYEALYRDILPELDLVL 119
Cdd:cd11383     1 GLMGKTGAGKSSLCNALFGTEVAAVGDRRPTTRAAQAYVWQTGGDGLVLLDLPGVGERGRRDREYEELYRRLLPEADLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 120 WLIKADDRALSVDEYFWRYILHRGHQQVLFVVTQADktepchewdmagiqpspaqaqnirekteavfrlfrpvhPVVAVS 199
Cdd:cd11383    81 WLLDADDRALAADHDFYLLPLAGHDAPLLFVLNQVD--------------------------------------PVLAVS 122
                         170
                  ....*....|....*...
gi 1191363559 200 ARTGWELDTLVSALMTAL 217
Cdd:cd11383   123 ARTGWGLDELAEALITAL 140
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
39-152 2.40e-16

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 73.42  E-value: 2.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  39 IGIMGKSGAGKSSLCNALFqGEVTPVSDVHAGTREVRRFRLSGHGHSMVITDLPGVGESRDRDAEYEALYRDILpELDLV 118
Cdd:pfam01926   2 VALVGRPNVGKSTLINALT-GAKAIVSDYPGTTRDPNEGRLELKGKQIILVDTPGLIEGASEGEGLGRAFLAII-EADLI 79
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1191363559 119 LWLIKADDRALSVDEYFWRYiLHRGHQQVLFVVT 152
Cdd:pfam01926  80 LFVVDSEEGITPLDEELLEL-LRENKKPIILVLN 112
era PRK00089
GTPase Era; Reviewed
39-220 6.45e-06

GTPase Era; Reviewed


Pssm-ID: 234624 [Multi-domain]  Cd Length: 292  Bit Score: 46.58  E-value: 6.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  39 IGIMGKSGAGKSSLCNALFQGEVTPVSDVhAGTRevrRFRLSG---HGHS-MVITDLPGVGESRDR------DAEYEALy 108
Cdd:PRK00089    8 VAIVGRPNVGKSTLLNALVGQKISIVSPK-PQTT---RHRIRGivtEDDAqIIFVDTPGIHKPKRAlnramnKAAWSSL- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 109 RDIlpelDLVLWLIKADDRALSVDEYFWRyILHRGHQQVLFVVTQADKTEPchewdmagiqpspaqAQNIREKTEAVFRL 188
Cdd:PRK00089   83 KDV----DLVLFVVDADEKIGPGDEFILE-KLKKVKTPVILVLNKIDLVKD---------------KEELLPLLEELSEL 142
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1191363559 189 FrPVHPVVAVSARTGWELDTLVSALMTALPDH 220
Cdd:PRK00089  143 M-DFAEIVPISALKGDNVDELLDVIAKYLPEG 173
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
36-156 2.59e-05

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 43.51  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  36 EPVIGIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVR--RFRLSGHGHSMVITDLPGVGE-SRDRDAEYEALYRdIL 112
Cdd:TIGR00231   1 DIKIVIVGHPNVGKSTLLNSLLGNKGSITEYYPGTTRNYVttVIEEDGKTYKFNLLDTAGQEDyDAIRRLYYPQVER-SL 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1191363559 113 PELDLVLWLIKADDRALSVDEYFWRYIlhRGHQQVLFVVTQADK 156
Cdd:TIGR00231  80 RVFDIVILVLDVEEILEKQTKEIIHHA--DSGVPIILVGNKIDL 121
 
Name Accession Description Interval E-value
YeeP COG3596
Predicted GTPase [General function prediction only];
1-281 4.04e-72

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 224.65  E-value: 4.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559   1 MNPS-DAIEAIEKPLSSLPYSLSRHILEHLR--KLTSHEPVIGIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVRRF 77
Cdd:COG3596     1 MSTEvSSLTERLEALKRLPQVLRELLAEALErlLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGVGRPCTREIQRY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  78 RL-SGHGHSMVITDLPGVGESRDRDAEYEAlYRDILPELDLVLWLIKADDRALSVDEYFWRYILHRGHQ-QVLFVVTQAD 155
Cdd:COG3596    81 RLeSDGLPGLVLLDTPGLGEVNERDREYRE-LRELLPEADLILWVVKADDRALATDEEFLQALRAQYPDpPVLVVLTQVD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 156 KTEPCHEWDMAGIQPSPAQAQNIREKTEAVFRLF----RPVHPVVAVSARTGWELDTLVSALMTALPDHAASPLMTRLqd 231
Cdd:COG3596   160 RLEPEREWDPPYNWPSPPKEQNIRRALEAIAEQLgvpiDRVIPVSAAEDRTGYGLEELVDALAEALPEAKRSRLARLL-- 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1191363559 232 elrtesvRAQAREQFTGAVDRIFDTAESVCVAsvARTVLRAVRDTVVSVA 281
Cdd:COG3596   238 -------RAKAIDRYTLLAAAAALLAAALLAL--LALLLAALAAAPVALA 278
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
40-217 2.70e-61

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 190.63  E-value: 2.70e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  40 GIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVRRFRLSGHGHSMVITDLPGVGESRDRDAEYEALYRDILPELDLVL 119
Cdd:cd11383     1 GLMGKTGAGKSSLCNALFGTEVAAVGDRRPTTRAAQAYVWQTGGDGLVLLDLPGVGERGRRDREYEELYRRLLPEADLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 120 WLIKADDRALSVDEYFWRYILHRGHQQVLFVVTQADktepchewdmagiqpspaqaqnirekteavfrlfrpvhPVVAVS 199
Cdd:cd11383    81 WLLDADDRALAADHDFYLLPLAGHDAPLLFVLNQVD--------------------------------------PVLAVS 122
                         170
                  ....*....|....*...
gi 1191363559 200 ARTGWELDTLVSALMTAL 217
Cdd:cd11383   123 ARTGWGLDELAEALITAL 140
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
40-215 1.87e-30

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 112.16  E-value: 1.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  40 GIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTRE--VRRFRLSGHGHSMVITDLPGVGESRDRDaeYEALYRDILPELDL 117
Cdd:cd00882     1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPGTTRDpdVYVKELDKGKVKLVLVDTPGLDEFGGLG--REELARLLLRGADL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 118 VLWLIKADDRALSVDEYFWRYILHRGHQQ-VLFVVTQADKTEPCHEWdmagiqpspaqaqnirEKTEAVFRLFRPVHPVV 196
Cdd:cd00882    79 ILLVVDSTDRESEEDAKLLILRRLRKEGIpIILVGNKIDLLEEREVE----------------ELLRLEELAKILGVPVF 142
                         170
                  ....*....|....*....
gi 1191363559 197 AVSARTGWELDTLVSALMT 215
Cdd:cd00882   143 EVSAKTGEGVDELFEKLIE 161
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
40-213 1.90e-19

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 83.06  E-value: 1.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  40 GIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVRRFRL-SGHGHSMVITDLPGVGESRDRDAEYEALYRDILPELDLV 118
Cdd:cd00880     1 AIFGRPNVGKSSLLNALLGQNVGIVSPIPGTTRDPVRKEWeLLPLGPVVLIDTPGLDEEGGLGRERVEEARQVADRADLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 119 LWLIKADdraLSVDEYFWRYI-LHRGHQQVLFVVTQADKTepchewdmagiqPSPAQAQNIREKTeavfRLFRPVHPVVA 197
Cdd:cd00880    81 LLVVDSD---LTPVEEEAKLGlLRERGKPVLLVLNKIDLV------------PESEEEELLRERK----LELLPDLPVIA 141
                         170
                  ....*....|....*.
gi 1191363559 198 VSARTGWELDTLVSAL 213
Cdd:cd00880   142 VSALPGEGIDELRKKI 157
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
39-152 2.40e-16

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 73.42  E-value: 2.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  39 IGIMGKSGAGKSSLCNALFqGEVTPVSDVHAGTREVRRFRLSGHGHSMVITDLPGVGESRDRDAEYEALYRDILpELDLV 118
Cdd:pfam01926   2 VALVGRPNVGKSTLINALT-GAKAIVSDYPGTTRDPNEGRLELKGKQIILVDTPGLIEGASEGEGLGRAFLAII-EADLI 79
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1191363559 119 LWLIKADDRALSVDEYFWRYiLHRGHQQVLFVVT 152
Cdd:pfam01926  80 LFVVDSEEGITPLDEELLEL-LRENKKPIILVLN 112
DLP_2 cd09912
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The ...
47-201 2.78e-14

Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.


Pssm-ID: 206739 [Multi-domain]  Cd Length: 180  Bit Score: 69.50  E-value: 2.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  47 AGKSSLCNALFQGEVTPVSDVHA-GTREVRRFRLSGHghsMVITDLPGVGESRDRDAEyeaLYRDILPELDLVLWLIKAd 125
Cdd:cd09912    11 AGKSTLLNALLGEEVLPTGVTPTtAVITVLRYGLLKG---VVLVDTPGLNSTIEHHTE---ITESFLPRADAVIFVLSA- 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191363559 126 DRALS-VDEYFWRYILHRGHQQVLFVVTQADKTEPcHEWDMagiqpspAQAQNIREKTEAVFRLFRPvhPVVAVSAR 201
Cdd:cd09912    84 DQPLTeSEREFLKEILKWSGKKIFFVLNKIDLLSE-EELEE-------VLEYSREELGVLELGGGEP--RIFPVSAK 150
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
35-213 3.61e-13

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 66.16  E-value: 3.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  35 HEPVIGIMGKSGAGKSSLCNALFQGEVTPvsDVHAGTREV----RRFRLSGHGHSMVITDLPGVGESRdrdaEYEALYRD 110
Cdd:COG1100     2 GEKKIVVVGTGGVGKTSLVNRLVGDIFSL--EKYLSTNGVtidkKELKLDGLDVDLVIWDTPGQDEFR----ETRQFYAR 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 111 ILPELDLVLWLIKADDRALSVDEYFWRYILHR--GHQQVLFVVTQADKTEpchEWDmagIQPSPAQAQNIREKteavfrl 188
Cdd:COG1100    76 QLTGASLYLFVVDGTREETLQSLYELLESLRRlgKKSPIILVLNKIDLYD---EEE---IEDEERLKEALSED------- 142
                         170       180
                  ....*....|....*....|....*
gi 1191363559 189 frPVHPVVAVSARTGWELDTLVSAL 213
Cdd:COG1100   143 --NIVEVVATSAKTGEGVEELFAAL 165
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
39-213 1.12e-12

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 64.84  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  39 IGIMGKSGAGKSSLCNALF-QGEVTPVSDVHAGTREVRRFRLsghGHSMVITDLPGVGE---SRDRDAEYEALYRDIL-- 112
Cdd:cd01876     2 VAFAGRSNVGKSSLINALTnRKKLARTSKTPGRTQLINFFNV---GDKFRLVDLPGYGYakvSKEVREKWGKLIEEYLen 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 113 -PELDLVLWLIKADDRALSVDEYFWRYILHRGhQQVLFVVTQADKTepchewdmagiqpSPAQAQNIREKTEAVFRLFRP 191
Cdd:cd01876    79 rENLKGVVLLIDARHGPTPIDLEMLEFLEELG-IPFLIVLTKADKL-------------KKSELAKVLKKIKEELNLFNI 144
                         170       180
                  ....*....|....*....|..
gi 1191363559 192 VHPVVAVSARTGWELDTLVSAL 213
Cdd:cd01876   145 LPPVILFSSKKGTGIDELRALI 166
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
41-213 3.99e-11

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 60.20  E-value: 3.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  41 IMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVRRFRLSGHGHSMVITDLPGVgesRDRDAEYEAL----YRDILPELD 116
Cdd:cd04164     8 IAGKPNVGKSSLLNALAGRDRAIVSDIAGTTRDVIEEEIDLGGIPVRLIDTAGL---RETEDEIEKIgierAREAIEEAD 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 117 LVLWLIkadDRALSVDEYFWRYILHRGHQQVLFVVTQADKtepchewdmagiqpspaqaqnireKTEAVFRLFRPVHPVV 196
Cdd:cd04164    85 LVLLVV---DASEGLDEEDLEILELPAKKPVIVVLNKSDL------------------------LSDAEGISELNGKPII 137
                         170
                  ....*....|....*..
gi 1191363559 197 AVSARTGWELDTLVSAL 213
Cdd:cd04164   138 AISAKTGEGIDELKEAL 154
MnmE_helical pfam12631
MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An ...
41-213 7.86e-07

MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An N-terminal domain, a helical domain and a GTPase domain which is nested within the helical domain. This family represents the helical domain.


Pssm-ID: 463649 [Multi-domain]  Cd Length: 326  Bit Score: 49.79  E-value: 7.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  41 IMGKSGAGKSSLCNALFQGEVTPVSDVhAG-TREVRRFRLSGHGHSMVITDLPGVgesRDRDAEYEAL----YRDILPEL 115
Cdd:pfam12631  99 IVGKPNVGKSSLLNALLGEERAIVTDI-PGtTRDVIEETINIGGIPLRLIDTAGI---RETDDEVEKIgierAREAIEEA 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 116 DLVLWLIkaDDRALSVDEYFWRYILHRGHQQVLFVVTQADKTepchewdmagiqpspaqaqnirekTEAVFRLFRPVHPV 195
Cdd:pfam12631 175 DLVLLVL--DASRPLDEEDLEILELLKDKKPIIVVLNKSDLL------------------------GEIDELEELKGKPV 228
                         170
                  ....*....|....*...
gi 1191363559 196 VAVSARTGWELDTLVSAL 213
Cdd:pfam12631 229 LAISAKTGEGLDELEEAI 246
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
41-228 8.08e-07

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 49.67  E-value: 8.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  41 IMGKSGAGKSSLCNALFQGEVTPVSDVhAG-TREVRRFRLSGHGHSMVITDLPGVGESRD----------RDAEYEAlyr 109
Cdd:COG0486   218 IVGRPNVGKSSLLNALLGEERAIVTDI-AGtTRDVIEERINIGGIPVRLIDTAGLRETEDevekigieraREAIEEA--- 293
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 110 dilpelDLVLWLIKADDRALSVDEYFWRYILHRghqQVLFVVTQADKTepchewdmagiqpsPAQAQNIREkteavfrlf 189
Cdd:COG0486   294 ------DLVLLLLDASEPLTEEDEEILEKLKDK---PVIVVLNKIDLP--------------SEADGELKS--------- 341
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1191363559 190 RPVHPVVAVSARTGWELDTLVSAL---MTALPDHAASPLMTR 228
Cdd:COG0486   342 LPGEPVIAISAKTGEGIDELKEAIlelVGEGALEGEGVLLTN 383
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
39-216 9.86e-07

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 47.81  E-value: 9.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  39 IGIMGKSGAGKSSLCNALFQGEVTPVSDVhAG-TREVRRFRLSGHGHSMVITDLPGVGE--SRDRDAEYEALYR--DILP 113
Cdd:cd01895     5 IAIIGRPNVGKSSLLNALLGEERVIVSDI-AGtTRDSIDVPFEYDGQKYTLIDTAGIRKkgKVTEGIEKYSVLRtlKAIE 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 114 ELDLVLWLIKADDRALSVDEYFWRYILHRGhQQVLFVVTQadktepcheWDmaGIQPSPAQAQNIREKTEAVFRLFRPVh 193
Cdd:cd01895    84 RADVVLLVLDASEGITEQDLRIAGLILEEG-KALIIVVNK---------WD--LVEKDEKTMKEFEKELRRKLPFLDYA- 150
                         170       180
                  ....*....|....*....|...
gi 1191363559 194 PVVAVSARTGWELDTLVSALMTA 216
Cdd:cd01895   151 PIVFISALTGQGVDKLFDAIKEV 173
era PRK00089
GTPase Era; Reviewed
39-220 6.45e-06

GTPase Era; Reviewed


Pssm-ID: 234624 [Multi-domain]  Cd Length: 292  Bit Score: 46.58  E-value: 6.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  39 IGIMGKSGAGKSSLCNALFQGEVTPVSDVhAGTRevrRFRLSG---HGHS-MVITDLPGVGESRDR------DAEYEALy 108
Cdd:PRK00089    8 VAIVGRPNVGKSTLLNALVGQKISIVSPK-PQTT---RHRIRGivtEDDAqIIFVDTPGIHKPKRAlnramnKAAWSSL- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 109 RDIlpelDLVLWLIKADDRALSVDEYFWRyILHRGHQQVLFVVTQADKTEPchewdmagiqpspaqAQNIREKTEAVFRL 188
Cdd:PRK00089   83 KDV----DLVLFVVDADEKIGPGDEFILE-KLKKVKTPVILVLNKIDLVKD---------------KEELLPLLEELSEL 142
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1191363559 189 FrPVHPVVAVSARTGWELDTLVSALMTALPDH 220
Cdd:PRK00089  143 M-DFAEIVPISALKGDNVDELLDVIAKYLPEG 173
trmE PRK05291
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
41-228 1.84e-05

tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;


Pssm-ID: 235392 [Multi-domain]  Cd Length: 449  Bit Score: 45.87  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  41 IMGKSGAGKSSLCNALFQGEVTPVSDVhAG-TREVRRFRLSGHGHSMVITDLPGVGESRDrdaEYEAL----YRDILPEL 115
Cdd:PRK05291  220 IAGRPNVGKSSLLNALLGEERAIVTDI-AGtTRDVIEEHINLDGIPLRLIDTAGIRETDD---EVEKIgierSREAIEEA 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 116 DLVLWLIKADDRALSVDEYFWRYILHRghqQVLFVVTQADKTEPCHEWDMAGiqpspaqaqnirekteavfrlfrpvHPV 195
Cdd:PRK05291  296 DLVLLVLDASEPLTEEDDEILEELKDK---PVIVVLNKADLTGEIDLEEENG-------------------------KPV 347
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1191363559 196 VAVSARTGWELDTLVSAL----MTALPDHAASPLMTR 228
Cdd:PRK05291  348 IRISAKTGEGIDELREAIkelaFGGFGGNQEGVFLTN 384
Era COG1159
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];
39-220 1.87e-05

GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440773 [Multi-domain]  Cd Length: 290  Bit Score: 45.36  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  39 IGIMGKSGAGKSSLCNALFqGE-VTPVSDVhAGTrevRRFRLSG---HGHS-MVITDLPGVGESRDR------DAEYEAL 107
Cdd:COG1159     6 VAIVGRPNVGKSTLLNALV-GQkVSIVSPK-PQT---TRHRIRGivtREDAqIVFVDTPGIHKPKRKlgrrmnKAAWSAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 108 YrdilpELDLVLWLIKADDRALSVDEYFWRyILHRGHQQVLFVVTQADKTEPchewdmagiqpspaqaQNIREKTEAVFR 187
Cdd:COG1159    81 E-----DVDVILFVVDATEKIGEGDEFILE-LLKKLKTPVILVINKIDLVKK----------------EELLPLLAEYSE 138
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1191363559 188 LFrPVHPVVAVSARTGWELDTLVSALMTALPDH 220
Cdd:COG1159   139 LL-DFAEIVPISALKGDNVDELLDEIAKLLPEG 170
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
36-156 2.59e-05

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 43.51  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  36 EPVIGIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVR--RFRLSGHGHSMVITDLPGVGE-SRDRDAEYEALYRdIL 112
Cdd:TIGR00231   1 DIKIVIVGHPNVGKSTLLNSLLGNKGSITEYYPGTTRNYVttVIEEDGKTYKFNLLDTAGQEDyDAIRRLYYPQVER-SL 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1191363559 113 PELDLVLWLIKADDRALSVDEYFWRYIlhRGHQQVLFVVTQADK 156
Cdd:TIGR00231  80 RVFDIVILVLDVEEILEKQTKEIIHHA--DSGVPIILVGNKIDL 121
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
39-214 3.40e-05

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 43.22  E-value: 3.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  39 IGIMGKSGAGKSSLCNALFQGEVTPVSDVhAGTrevRRFRLSG---HGHS-MVITDLPGVGESRDRDAEY---EAlyRDI 111
Cdd:cd04163     6 VAIIGRPNVGKSTLLNALVGQKISIVSPK-PQT---TRNRIRGiytDDDAqIIFVDTPGIHKPKKKLGERmvkAA--WSA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 112 LPELDLVLWLIKADDRALSVDEYFWRyILHRGHQQVLFVVTQADKTEPchewdmagiqpspaqaQNIREKTEAVFRLFRP 191
Cdd:cd04163    80 LKDVDLVLFVVDASEWIGEGDEFILE-LLKKSKTPVILVLNKIDLVKD----------------KEDLLPLLEKLKELHP 142
                         170       180
                  ....*....|....*....|...
gi 1191363559 192 VHPVVAVSARTGWELDTLVSALM 214
Cdd:cd04163   143 FAEIFPISALKGENVDELLEYIV 165
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
25-96 8.74e-05

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 42.77  E-value: 8.74e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191363559  25 ILEHLRKLTShepviGIMGKSGAGKSSLCNALFQGE---VTPVSDVHA-G---TREVRRFRLSGHGhsMVItDLPGVGE 96
Cdd:cd01854    79 LRELLKGKTS-----VLVGQSGVGKSTLLNALLPELvlaTGEISEKLGrGrhtTTHRELFPLPGGG--LII-DTPGFRE 149
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
2-96 2.61e-04

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 40.99  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559   2 NPSDAIEAIEKPLSSLPY------SLSRHILEHLRK-LTSHepVIGIMGKSGAGKSSLCNALFQGEVTPVSDV------- 67
Cdd:pfam03193  67 DEEEELEELLKIYRAIGYpvlfvsAKTGEGIEALKElLKGK--TTVLAGQSGVGKSTLLNALLPELDLRTGEIseklgrg 144
                          90       100       110
                  ....*....|....*....|....*....|
gi 1191363559  68 -HAgTREVRRFRLSGHGhsmVITDLPGVGE 96
Cdd:pfam03193 145 rHT-TTHVELFPLPGGG---LLIDTPGFRE 170
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
41-94 3.13e-04

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 41.64  E-value: 3.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191363559  41 IMGKSGAGKSSLCNALFQGEVTPVSDVHAG-------TREVRRFRLSGHGhsMVItDLPGV 94
Cdd:COG1162   171 LVGQSGVGKSTLINALLPDADLATGEISEKlgrgrhtTTHAELYPLPGGG--WLI-DTPGF 228
EngB COG0218
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, ...
37-217 3.35e-04

GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 439988 [Multi-domain]  Cd Length: 194  Bit Score: 40.83  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559  37 PVIGIMGKSGAGKSSLCNALFQ--------GevTPvsdvhaG-TREVRRFRLsghGHSMVITDLPGVG---ESRDRDAEY 104
Cdd:COG0218    24 PEIAFAGRSNVGKSSLINALTNrkklartsK--TP------GkTQLINFFLI---NDKFYLVDLPGYGyakVSKAEKEKW 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191363559 105 EALYRDIL---PELDLVLWLI------KADDRALsvdeYFWryiLHRGHQQVLFVVTQADKtepchewdmagiqPSPAQA 175
Cdd:COG0218    93 QKLIEDYLegrENLKGVVLLIdirhppKELDLEM----LEW---LDEAGIPFLIVLTKADK-------------LKKSEL 152
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1191363559 176 QNIREKTEAVFRLFRPVHPVVAVSARTGWELDTLVSALMTAL 217
Cdd:COG0218   153 AKQLKAIKKALGKDPAAPEVILFSSLKKEGIDELRAAIEEWL 194
ABC_tran pfam00005
ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...
38-80 1.09e-03

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.


Pssm-ID: 394964 [Multi-domain]  Cd Length: 150  Bit Score: 38.78  E-value: 1.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1191363559  38 VIGIMGKSGAGKSSLCNALfQGEVTPVS--------DVHAGTREVRRFRLS 80
Cdd:pfam00005  13 ILALVGPNGAGKSTLLKLI-AGLLSPTEgtilldgqDLTDDERKSLRKEIG 62
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
39-99 1.39e-03

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 39.22  E-value: 1.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191363559  39 IGIMGKSGAGKSSLCNALFQGEVTPVSDVHAGTREVRRFRLSGHGHSMVITDLPGVGESRD 99
Cdd:cd01853    34 ILVLGKTGVGKSSTINSIFGERKVSVSAFQSETLRPREVSRTVDGFKLNIIDTPGLLESQD 94
PRK00098 PRK00098
GTPase RsgA; Reviewed
41-96 2.18e-03

GTPase RsgA; Reviewed


Pssm-ID: 234631 [Multi-domain]  Cd Length: 298  Bit Score: 39.03  E-value: 2.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191363559  41 IMGKSGAGKSSLCNALFQG---EVTPVSDVH-AG---TREVRRFRLSGHGHsmvITDLPGVGE 96
Cdd:PRK00098  169 LAGQSGVGKSTLLNALAPDlelKTGEISEALgRGkhtTTHVELYDLPGGGL---LIDTPGFSS 228
PLN03232 PLN03232
ABC transporter C family member; Provisional
3-58 2.22e-03

ABC transporter C family member; Provisional


Pssm-ID: 215640 [Multi-domain]  Cd Length: 1495  Bit Score: 39.57  E-value: 2.22e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191363559    3 PSDAIEAIE--KPLSSLPYSLSRHILE-HLRKLTSHEPV-------------IGIMGKSGAGKSSLCNALFQ 58
Cdd:PLN03232  1213 PSEATAIIEnnRPVSGWPSRGSIKFEDvHLRYRPGLPPVlhglsffvspsekVGVVGRTGAGKSSMLNALFR 1284
p47_IIGP_like cd04104
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase ...
39-95 4.26e-03

p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase family consists of several highly homologous proteins, including IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1. They are found in higher eukaryotes where they play a role in immune resistance against intracellular pathogens. p47 proteins exist at low resting levels in mouse cells, but are strongly induced by Type II interferon (IFN-gamma). ITGP is critical for resistance to Toxoplasma gondii infection and in involved in inhibition of Coxsackievirus-B3-induced apoptosis. TGTP was shown to limit vesicular stomatitis virus (VSV) infection of fibroblasts in vitro. IRG-47 is involved in resistance to T. gondii infection. LRG-47 has been implicated in resistance to T. gondii, Listeria monocytogenes, Leishmania, and mycobacterial infections. IIGP1 has been shown to localize to the ER and to the Golgi membranes in IFN-induced cells and inflamed tissues. In macrophages, IIGP1 interacts with hook3, a microtubule binding protein that participates in the organization of the cis-Golgi compartment.


Pssm-ID: 206690  Cd Length: 197  Bit Score: 37.69  E-value: 4.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191363559  39 IGIMGKSGAGKSSLCNALfQG------EVTPVSDVHAgTREVRRFRlSGHGHSMVITDLPGVG 95
Cdd:cd04104     4 IAVTGESGAGKSSFINAL-RGigheeeGAAPTGVVET-TMKRTPYP-HPKFPNVTLWDLPGIG 63
ABCC_MRP_domain2 cd03244
ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ...
39-57 5.00e-03

ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213211 [Multi-domain]  Cd Length: 221  Bit Score: 37.47  E-value: 5.00e-03
                          10
                  ....*....|....*....
gi 1191363559  39 IGIMGKSGAGKSSLCNALF 57
Cdd:cd03244    33 VGIVGRTGSGKSSLLLALF 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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