|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
6-425 |
0e+00 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 872.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 6 FALCDVNSFYASCETVFRPDLKGKPVVVLSNNDGCVISRSPEAKPWVV-MGAPYFKQKEAFRRHGVVCFSSNYELYGDMS 84
Cdd:PRK03609 2 FALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALGIkMGDPWFKQKDLFRRCGVVCFSSNYELYADMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 85 NRVMSTLEALSPRVEIYSIDEAFCDLTGVRNCRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAAKKWPQQTG 164
Cdd:PRK03609 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 165 GVVDLSNLERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFNVVLERTVRELRGEPCLALEEFA 244
Cdd:PRK03609 162 GVVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLEEFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 245 PAKQEIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFAPNETWYGNSASVKLLTPTQDSRD 324
Cdd:PRK03609 242 PTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQDSRD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 325 IISAATRCLDAIWKEGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEKLMEVLDTLNTKQGRGTLYFAGQGIQPPWQ 404
Cdd:PRK03609 322 IIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNAKSGKGTLYFAGQGIAQQWQ 401
|
410 420
....*....|....*....|.
gi 1195018154 405 LRRQMLSPRYTTRFSDLLVVR 425
Cdd:PRK03609 402 MKREMLSPRYTTRWSDLLRVK 422
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
7-352 |
0e+00 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 518.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 7 ALCDVNSFYASCETVFRPDLKGKPVVVLSNNDGCVISRSPEAKP-WVVMGAPYFKQKEAFRRHGVVCFSSNYELYGDMSN 85
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKAlGIKMGSPYFKVPDLLERHGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 86 RVMSTLEALSPRVEIYSIDEAFCDLTGVRNCRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAAKKWpQQTGG 165
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKK-NPYGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 166 VVDLSNLERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFNVVLERTVRELRGEPCLALEEFAP 245
Cdd:cd01700 160 VVDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEYPP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 246 AKQEIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFAPNETWYgnSASVKLLTPTQDSRDI 325
Cdd:cd01700 240 PKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYY--SATNTLPYPTNDTREI 317
|
330 340
....*....|....*....|....*..
gi 1195018154 326 ISAATRCLDAIWKEGHRYQKAGVMLGD 352
Cdd:cd01700 318 VKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
5-350 |
1.94e-131 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 381.41 E-value: 1.94e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 5 VFALCDVNSFYASCETVFRPDLKGKPVVVLS-NNDGCVISRSPEAKPW-VVMGAPYFKQKEAFRrhGVVCFSSNYELYGD 82
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFgVRSGMPLFQARRLCP--DLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 83 MSNRVMSTLEALSPRVEIYSIDEAFCDLTG-VRNCRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAAKKwpq 161
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGsARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 162 qtGGVVDLSnLERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFNVVLERTVRELRGEPCLALE 241
Cdd:COG0389 157 --DGLTVIP-PGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 242 EFAPAKQeIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFAPnetwygNSASVKLLTPTQD 321
Cdd:COG0389 234 PRRPRKS-IGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRT------TTRSRTLPEPTDD 306
|
330 340
....*....|....*....|....*....
gi 1195018154 322 SRDIISAATRCLDAIWKEGHRYQKAGVML 350
Cdd:COG0389 307 TAELLRAARELLERIYRPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
9-339 |
1.74e-59 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 196.97 E-value: 1.74e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 9 CDVNSFYASCETVFRPDLKGKPVVVLSNNDGCVISR-SPEAKPWVVMGA-PYFKqkeAFRR--HGVVcFSSNYELYGDMS 84
Cdd:cd03586 3 IDMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVSTaSYEARKFGVRSAmPIFQ---AKKLcpNLIF-VPPRFDKYREVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 85 NRVMSTLEALSPRVEIYSIDEAFCDLTGVRNCRDL-TDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAAKkwPQ-Q 162
Cdd:cd03586 79 RQIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSaTEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNK--PNgL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 163 TggVVDLSNLErqrKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFNVVLERTVRELRGEPCLALEE 242
Cdd:cd03586 157 T--VIPPEDVE---EFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 243 FAPAKQeIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFapnETWygnSASVKLLTPTQDS 322
Cdd:cd03586 232 DRERKS-IGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADF---STR---TRSRTLPEPTDDA 304
|
330
....*....|....*..
gi 1195018154 323 RDIISAATRCLDAIWKE 339
Cdd:cd03586 305 EDIYELALELLEELLDG 321
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
10-297 |
1.75e-55 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 186.80 E-value: 1.75e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVVLSNND--GCVISRSPEAKPW-VVMGAPYFKQKEAFRRHGVVcfSSNYELYGDMSNR 86
Cdd:cd00424 4 DFDNFFASVEQLARPELKGRPVVVVPFNSdsTCVIACSYEARKYgVKRGMPVREARKMCPNLILV--PARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 87 VMSTLEALSPRVEIYSIDEAFCDLTG-VRNCRDLTDFGKEIRDTVLKRT-HLTLGVGIAQTKTLAKLANHAAKKwPQQTg 164
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGsARLLGLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKP-DGLT- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 165 gVVDLSNLERqrkLMAALPVDEVWGVGRRISKKLTAMGIETVLDLAD-THIAVIRKHFNVVLERTVRELRGEPCLALEEf 243
Cdd:cd00424 160 -ILDPEDLPG---FLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAaSPDALLALWGGVSGERLWYALRGIDDEPLSP- 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1195018154 244 APAKQEIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKT 297
Cdd:cd00424 235 PRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRT 288
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
1-395 |
1.17e-54 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 186.75 E-value: 1.17e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 1 MGCDVFaLCDVNSFYASCETVFRPDLKGKPVVVL---SNNDGCVISRSPEAKPWVVMGAPYFKQKEAFRRHGVVcFSSNY 77
Cdd:PRK03103 1 MERVIL-LVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVV-VKPRM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 78 ELYGDMSNRVMSTLEALSPRVEIYSIDEAFCDLTGvrnCRDLtdFG------KEIRDTVLKRTHLTLGVGIAQTKTLAKL 151
Cdd:PRK03103 79 QRYIDVSLQITRILEDFTDLVEPFSIDEQFLDVTG---SQKL--FGspleiaQKIQQRIMRETGVYARVGIGPNKLLAKM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 152 A-NHAAKKWPQqtgGVVDLsNLERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFNV---VLER 227
Cdd:PRK03103 154 AcDNFAKKNPD---GLFTL-DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGIngeVLWR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 228 TVRELRGEPclaLEEFAPAKQeivfsRSFGERIT------EYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFa 301
Cdd:PRK03103 230 TANGIDYSP---VTPHSLDRQ-----KAIGHQMTlprdyrGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADF- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 302 pnETWYGNSASVKLLTPTQDSRDIISAATRCLDAIWkEGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRpgsEKLMEVLD 381
Cdd:PRK03103 301 --DWPTGFSRQMTLPEPTNLAMEVYEAACKLFHRHW-DGKPVRRVGVTLSNLVSDDVWQLSLFGDRERK---RSLGYVMD 374
|
410
....*....|....
gi 1195018154 382 TLNTKQGRGTLYFA 395
Cdd:PRK03103 375 DIKNRFGPTAILRA 388
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
9-152 |
6.39e-40 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 139.63 E-value: 6.39e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 9 CDVNSFYASCETVFRPDLKGKPVVVLSNN-DGCVISRSPEAKPWVV-MGAPYFKQKEAFRRhgVVCFSSNYELYGDMSNR 86
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYGVrSGMPVFEAKKLCPN--LIVVPPDLELYRRASRK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1195018154 87 VMSTL-EALSPRVEIYSIDEAFCDLTGVRNCRDLT-DFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLA 152
Cdd:pfam00817 79 IFEILrRFSTPKVEQASIDEAFLDLTGLEKLFGAEeALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
10-334 |
1.01e-39 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 147.77 E-value: 1.01e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVVlsnndGCVISRSpeakpwVVMGAPYfkqkEAfRRHGV-----------------VC 72
Cdd:PRK03348 11 DMDAFFASVEQLTRPTLRGRPVLV-----GGLGGRG------VVAGASY----EA-RVFGArsampmhqarrlvgngaVV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 73 FSSNYELYGDMSNRVMSTLEALSPRVEIYSIDEAFCDLTGV--RNCRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAK 150
Cdd:PRK03348 75 LPPRFVVYRAASRRVFDTLRELSPVVEQLSFDEAFVEPAELagASAEEVEAFAERLRARVREETGLPASVGAGSGKQIAK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 151 LANHAAKkwPQqtgGVVdLSNLERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIA-VIRkhfnvVLERTV 229
Cdd:PRK03348 155 IASGLAK--PD---GIR-VVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAeVAN-----LLGATV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 230 -REL----RGEPCLALEEFAPAKQeIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFApne 304
Cdd:PRK03348 224 gPALhrlaRGIDDRPVAERAEAKQ-ISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFS--- 299
|
330 340 350
....*....|....*....|....*....|
gi 1195018154 305 TWygnSASVKLLTPTQDSRDIISAATRCLD 334
Cdd:PRK03348 300 TL---TRSATLPYATDDAAVLAATARRLLL 326
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
10-336 |
7.31e-39 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 142.85 E-value: 7.31e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVVLSNNDgcvisrsPEAKPWVVMGAPYfkqkEAfRRHGV----------------VCF 73
Cdd:PRK03352 11 DLDQFIAAVELLRRPELAGLPVIVGGNGD-------PTEPRKVVTCASY----EA-RAFGVragmplrtaarrcpdaVFL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 74 SSNYELYGDMSNRVMSTLEALSPRVEIYSIDEAFcdlTGVRNcRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLAN 153
Cdd:PRK03352 79 PSDPAAYDAASEEVMATLRDLGVPVEVWGWDEAF---LGVDT-DDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIAT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 154 HAAKKwpqqtGGVVDLSNlERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFN-------VVLE 226
Cdd:PRK03352 155 GFAKP-----AGVFRLTD-ANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpttgpwlLLLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 227 RTV--RELRGEPCLALeefapakqeivfSRS----FGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPF 300
Cdd:PRK03352 229 RGGgdTEVSAEPWVPR------------SRSrevtFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATF 296
|
330 340 350
....*....|....*....|....*....|....*.
gi 1195018154 301 apnetwYGNSASVKLLTPTQDSRDIISAATRCLDAI 336
Cdd:PRK03352 297 ------YTRTKIRKLPEPTTDPDVIEAAALDVLDRF 326
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
10-392 |
1.24e-35 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 135.54 E-value: 1.24e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVVLSN---NDGCVISRSPEAKPWVV---MgaPYFkqkEAFRR-HGVVCFSSNYELYGD 82
Cdd:PRK01810 11 DMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYGIrttM--PLW---EAKRLcPQLIVRRPNFDRYRE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 83 MSNRVMSTLEALSPRVEIYSIDEAFCDLTGVRNCRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAAKkwPQq 162
Cdd:PRK01810 86 ASRQMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKK--PL- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 163 tgGVVDLsnleRQR---KLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFNVVLERTVRELRGE---- 235
Cdd:PRK01810 163 --GITVL----RKRdvpEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIddrp 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 236 --PcLALEEFapakQEIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSpfapneTWYGNSASV 313
Cdd:PRK01810 237 vdP-EAIYQF----KSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYH------DRRTITRSK 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 314 KLLTPTQDSRDIISAATRCLDAIWkEGHRYQKAGVMLGDFF--SQGVAQLNLFD--DNAPRpgsEKLMEVLDTLNTKQGR 389
Cdd:PRK01810 306 TLKNPIWEKRDIFQAASRLFKQHW-NGDPVRLLGVTATDLEwkTEAVKQLDLFSfeEDAKE---EPLLAVIDQINDKYGM 381
|
...
gi 1195018154 390 GTL 392
Cdd:PRK01810 382 PLL 384
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
10-301 |
1.21e-30 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 120.59 E-value: 1.21e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVV--LSNNdGCVISRSPEAKPWVVMGA-PYFKQKEAFRrHGVVcFSSNYELYGDMSNR 86
Cdd:PRK14133 9 DMDAFFASVEQMDNPKLKGKPVIVggISER-GVVSTCSYEARKYGVHSAmPVFMAKKRCP-HGIF-LPVRHERYKEVSKN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 87 VMSTLEALSPRVEIYSIDEAFCDLTGVRncRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANhaakKWPQQTGgv 166
Cdd:PRK14133 86 IFKILYEVTPIVEPVSIDEAYLDITNIK--EEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDG-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 167 VDLSNLERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDL----ADTHIAVIRKHFNVVLERtVRELRGEPCLALEE 242
Cdd:PRK14133 158 IKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLlklsREFLIEYFGKFGVEIYER-IRGIDYREVEVSRE 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1195018154 243 FAPAKQEIVFSRSfgerITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFA 301
Cdd:PRK14133 237 RKSIGKETTLKKD----TKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQ 291
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
10-407 |
1.19e-27 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 113.16 E-value: 1.19e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVVlsnNDGCVISRSPEAKPWVVMGAPYFKQKEAFRRHGVVcFSSNYELYGDMSNRVMS 89
Cdd:PRK03858 10 DLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYGVRTAMGGRQARRLCPQAVV-VPPRMSAYSRASKAVFE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 90 TLEALSPRVEIYSIDEAFCDLTGvrnCRDLT----DFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAAKkwPQqtgG 165
Cdd:PRK03858 86 VFRDTTPLVEGLSIDEAFLDVGG---LRRISgtpvQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAK--PD---G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 166 VVdLSNLERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHiavirkhfNVVLERTVRELRGEPCLALE---- 241
Cdd:PRK03858 158 LL-VVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELP--------ESALVSLLGPAAGRHLHALAhnrd 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 242 ----EFAPAKQEIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFApnetwyGNSASVKLLT 317
Cdd:PRK03858 229 prrvETGRRRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFT------RATRSHTLPR 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 318 PTQDSRDIISAATRCLDAIWKE-GHR-YQKAGVMLGDFFSQGVAQLNL-FDDnaPRPGSEkLMEVLDTLNTKQGRGTLYF 394
Cdd:PRK03858 303 PTASTATLLAAARDLVAAAAPLiAERgLTLVGFAVSNLDDDGAQQLELpFGL--RRPGSA-LDAALDAVRDRFGNAAVTR 379
|
410
....*....|....
gi 1195018154 395 AGQ-GIQPPWQLRR 407
Cdd:PRK03858 380 AVLlGRDPGLEVPM 393
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
8-222 |
1.33e-26 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 109.49 E-value: 1.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 8 LCDVNSFYASCETVFRPDLKGKPVVVL-----SNNDGCVISRSPEAKPW-VVMGAPYFKQKEAFRrhGVVCFSSNYELYG 81
Cdd:PRK01216 5 FVDFDYFFAQVEEVLNPSLKGKPVVVCvysgrFEDSGAVATANYEARKLgIKAGMPIVEAKKILP--NAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 82 DMSNRVMSTLEALSPRVEIYSIDEAFCDLTG-VRNCRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAAKkwP 160
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDkVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAK--P 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195018154 161 QQTGGVVDlsnlERQRKLMAALPVDEVWGVGRRISKKLTAMGIETVLDladthiaVIRKHFN 222
Cdd:PRK01216 161 NGIKVIDD----EEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVD-------TLRIEFD 211
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
247-357 |
6.48e-23 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 92.62 E-value: 6.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 247 KQEIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFApnetwyGNSASVKLLTPTQDSRDII 326
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFR------TITRSVTLPSPTDDTDEIY 74
|
90 100 110
....*....|....*....|....*....|.
gi 1195018154 327 SAATRCLDAIWKeGHRYQKAGVMLGDFFSQG 357
Cdd:pfam11799 75 RAALRLLRRLYR-GRPVRLLGVSLSNLVPEG 104
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
376-424 |
3.03e-21 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 86.00 E-value: 3.03e-21
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1195018154 376 LMEVLDTLNTKQGRGTLYFAGQGIQPPWQLRRQMLSPRYTTRFSDLLVV 424
Cdd:pfam13438 1 LMAALDAINRRYGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
7-340 |
2.67e-20 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 91.61 E-value: 2.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 7 ALCDVNSFYASCETVFRPDLKGKPVVVLSNND---------GCVISRS---PEAK---PWVVMG-APYFKQKEAFRRHGV 70
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSiiavsyaarAFGVTRFmtiDEAKkkcPDLILAhVATYKKGEDEADYHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 71 VCFSSNY----ELYGDMSNRVMSTLEALSPRVEIYSIDEAFCDLtGVRNCrdltdfgKEIRDTVLKRTHLTLGVGIAQTK 146
Cdd:cd01702 81 NPSPARHkvslDPYRRASRKILNILKRFGDVVEKASIDEAYLDL-GSRIV-------EEIRQQVYDELGYTCSAGIAHNK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 147 TLAKLANhAAKKWPQQTggVVDLSNLErqrKLMAALPVDEVWGVGRRISKKLTA-MGIETVLDLADTHIAV--IRKHFNV 223
Cdd:cd01702 153 MLAKLAS-GMNKPNAQT--ILRNDAVA---SFLSSLPITSIRGLGGKLGEEIIDlLGLPTEGDVAGFRSSEsdLQEHFGE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 224 VLERTV-RELRGEPCLALEEfAPAKQEIVFSRSF-GERITEYEQMRQAICAYATRAAEKLRS-EHQYCRFISTF-VKTSP 299
Cdd:cd01702 227 KLGEWLyNLLRGIDHEPVKP-RPLPKSMGSSKNFpGKTALSTEDVQHWLLVLASELNSRLEDdRYENNRRPKTLvLSLRQ 305
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1195018154 300 FAPNETwygNSASVKLltPTQDSRDIISAATRCLDAIWKEG 340
Cdd:cd01702 306 RGDGVR---RSRSCAL--PRYDAQKIVKDAFKLIKAINEEG 341
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
14-221 |
4.71e-20 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 90.56 E-value: 4.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 14 FYASCETVFRPDLKGKPVVVLSNNDGcvisRSpeakpwVVMGAPYfkqkEAfRRHGV----------------VCFSSNY 77
Cdd:PRK02406 4 FYAAVEMRDNPELRGKPVAVGGSPGR----RG------VISTCNY----EA-RKFGVrsamptaqalklcpdlIFVPGRF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 78 ELYGDMSNRVMSTLEALSPRVEIYSIDEAFCDLTGVRNCRDL-TDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAA 156
Cdd:PRK02406 69 DVYKEVSRQIREIFRRYTDLIEPLSLDEAYLDVTDNKLCIGSaTLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWN 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195018154 157 KkwPQ-QTggVVDLSNLErqrKLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHF 221
Cdd:PRK02406 149 K--PNgLF--VITPEEVD---AFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHF 207
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
10-329 |
6.76e-19 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 88.14 E-value: 6.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVVlSNNDGC---VISRSPEAKPWVVMGAPYFKQkeAFRRHG-VVCFSSNYELYGDMSN 85
Cdd:cd01701 53 DFDCFFVSVSIRNRPDLKGKPVAV-CHGKGPnseIASCNYEARSYGIKNGMWVGQ--AKKLCPqLVTLPYDFEAYEEVSL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 86 RVMSTLEALSPRVEIYSIDEAFCDLTGVRNCR--DLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAAKkwPqqt 163
Cdd:cd01701 130 TFYEILASYTDNIEAVSCDEALIDITSLLEETyeLPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAK--P--- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 164 GGV--VDLSNLERQrklMAALPVDEVWGVGRRISKKLTAMGIET--VLDLADTHIAVIRKHFNVVL-ERTVRELRGEPCL 238
Cdd:cd01701 205 DGQyhLSAEKVEEF---LSQLKVGDLPGVGSSLAEKLVKLFGDTcgGLELRSKTKEKLQKVLGPKTgEKLYDYCRGIDDR 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 239 ALEEFAPAKQ---EIVFSRSFgERITEYEQMRQAICAYATRAAEKLRSEhqyCRFIS-TFVKTSPFAPNETW-YGN---- 309
Cdd:cd01701 282 PVTGEKERKSvsaEINYGIRF-TNVDDVEQFLQRLSEELSKRLEESNVT---GRQITlKLMKRAPGAPIEPPkYMGhgic 357
|
330 340
....*....|....*....|...
gi 1195018154 310 ---SASVKLLTPTQDSRDIISAA 329
Cdd:cd01701 358 dsfSKSSTLGVATDDSGVIGTEA 380
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
9-370 |
1.81e-17 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 83.83 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 9 CDvnSFYASCETVFRPDLKGKPVVVLSNNDG-----CVISRspeakpwvVMGA----PYFKQKEAFRrHGVVcFSSNYEL 79
Cdd:PRK02794 43 CD--AFYASVEKRDNPELRDKPVIIGGGKRGvvstaCYIAR--------IHGVrsamPMFKALKLCP-DAVV-IKPDMEK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 80 YGDMSNRVMSTLEALSPRVEIYSIDEAFCDLTGVRN------CRDLTDFGKEIRDTVlkrtHLTLGVGIAQTKTLAKLAn 153
Cdd:PRK02794 111 YVRVGREVRAMMQALTPLVEPLSIDEAFLDLSGTERlhgappAVVLARFARRVEREI----GITVSVGLSYNKFLAKIA- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 154 haakkwpqqtggvvdlSNLERQR-----------KLMAALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFN 222
Cdd:PRK02794 186 ----------------SDLDKPRgfsvigraealAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 223 VVLERTVRELRGEPCLALEEFAPAKQeIVFSRSFGERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTSPFAP 302
Cdd:PRK02794 250 SMGLRLWRLARGIDDRKVSPDREAKS-VSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRL 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195018154 303 netwygNSASVKLLTPTQDSRDIISAATRCLDaiwKE--GHRYQKAGVMLGDFFSQGVAQL-NLFDDNAPR 370
Cdd:PRK02794 329 ------RTRRRTLEDPTQLADRIFRTARELLE---KEtdGTAFRLIGIGVSDLSPADEADPpDLLDPQATR 390
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
10-210 |
1.65e-08 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 55.94 E-value: 1.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVVLSNNdgCVISRSPEAkpwvvmgapyfkqkeafRRHGVVCFSSNYEL---------- 79
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPLGIQQKY--IVVTCNYEA-----------------RRLGVKKLMSIKDAkeicpdlvlv 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 80 -------YGDMSNRVMSTLEALSP--RVEIYSIDEAFCDLTGVRncrdL---TDFGKEIRDTVLKRTHLTLGVGIAQTKT 147
Cdd:cd01703 65 ngedltpFRDMSKKVYRLLRSYSWndRVERLGFDENFMDVTEMR----LlvaSHIAYEMRERIENELGLTCCAGIASNKL 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1195018154 148 LAKLANhAAKKWPQQTG----GVVDLSNLERQRKLMaALPvdevwGVGRRISKKLTAMGIETVLDLA 210
Cdd:cd01703 141 LAKLVG-SVNKPNQQTTllppSCADLMDFMDLHDLR-KIP-----GIGYKTAAKLEAHGISSVRDLQ 200
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
173-203 |
1.53e-05 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 41.61 E-value: 1.53e-05
10 20 30
....*....|....*....|....*....|.
gi 1195018154 173 ERQRKLMAALPVDEVWGVGRRISKKLTAMGI 203
Cdd:pfam11798 2 DDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
10-300 |
2.21e-05 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 46.55 E-value: 2.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 10 DVNSFYASCETVFRPDLKGKPVVVLSN---NDGCVISRSPEAKPwvvmGAP-YFKQKeafrrhgvVC-----FSSNYELY 80
Cdd:PTZ00205 139 DMDMFYAAVEIKKHPEYAAIPLAIGTMtmlQTANYVARGRGIRQ----GMPgFLALK--------ICpnlliLPPDFDAY 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 81 GDMSNRVMSTLEALSPRVEIYSIDEAFCDLTG----VRNCRDLTDFGKEIRDTVLKRTHLTLGVGIAQTKTLAKLANHAA 156
Cdd:PTZ00205 207 NEESNTVRRIVAEYDPNYISFGLDELTLEVSAyierFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNIN 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 157 KKWPQQtggvvDLsNLERQRKLMA---ALPVDEVWGVGRRISKKLTAMGIETVLDLADTHIAVIRkhfnVVLERTVRELR 233
Cdd:PTZ00205 287 KPNGQH-----DL-NLHTRGDVMTyvrDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCY----ILHNNLFRFLL 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 234 G---------EPCLAL------EEFAPAKQEIVFSRSFgERITEYEQMRQAICAYATRAAEKLRSEHQYCRFISTFVKTS 298
Cdd:PTZ00205 357 GasigimqwpDAATAAntenceGATGGQRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWA 435
|
..
gi 1195018154 299 PF 300
Cdd:PTZ00205 436 SY 437
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
23-262 |
2.99e-03 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 39.67 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 23 RPDLKGKPVVVLS-NNDGCVISRSPEAKPwvvMG-APYFKQKEAFRR-HGVVCFSSNYELYGDMSNRVMSTLEALSPRVE 99
Cdd:cd03468 17 RPADDEAPLAVVErKKAGRILACNAAARA---AGvRPGMPLAEALALcPNLQVVEYDPEADARALQELALWLLRFTPLVA 93
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 100 IYSIDEAFCDLTGVrncrdLTDFGKEIR-----DTVLKRTHLTLGVGIAQTKTLAKLANHAAKKwpqqtGGVVDLSNLER 174
Cdd:cd03468 94 LDGPDGLLLDVTGC-----LHLFGGEDAlaaslRAALATLGLSARAGIADTPGAAWLLARAGGG-----RGVLRREALAA 163
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195018154 175 QRKLMAALPVDEVwGVGRRISKKLTAMGIETVLDLADTHIAVIRKHFNVVLERTVRELRGE--PCLALEEFAPAKQEIVf 252
Cdd:cd03468 164 ALVLLAPLPVAAL-RLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRdpEPLLFSPPPPAFDFRL- 241
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250
....*....|
gi 1195018154 253 SRSFGERITE 262
Cdd:cd03468 242 ELQLEEPIAR 251
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