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Conserved domains on  [gi|1197475503|gb|OUL88298|]
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glyoxalase [Paraburkholderia hospita]

Protein Classification

VOC family protein( domain architecture ID 10163498)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

CATH:  3.10.180.10
PubMed:  21820381

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VOC_like cd07246
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 14-140 1.19e-44

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


:

Pssm-ID: 319910 [Multi-domain]  Cd Length: 124  Bit Score: 142.82  E-value: 1.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  14 HTLTPHIIVAGAAEAIEFYKKAFNAVEQVRLPGPGGKLMHAQLKIGDSTLMLVDEMPDCGngaSFGPKELKGTPVVLHLY 93
Cdd:cd07246     1 TTVSPYLVVEDAAAAIAFYKKAFGAEELGRTTQEDGRVGHAELRIGGTVVMVADENPERG---ALSPTKLGGTPVIFHLY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1197475503  94 VNDADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATH 140
Cdd:cd07246    78 VEDVDATFARAVAAGAVVVEPVEDQFWGDRVGKVKDPFGHVWWLATP 124
 
Name Accession Description Interval E-value
VOC_like cd07246
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 14-140 1.19e-44

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


Pssm-ID: 319910 [Multi-domain]  Cd Length: 124  Bit Score: 142.82  E-value: 1.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  14 HTLTPHIIVAGAAEAIEFYKKAFNAVEQVRLPGPGGKLMHAQLKIGDSTLMLVDEMPDCGngaSFGPKELKGTPVVLHLY 93
Cdd:cd07246     1 TTVSPYLVVEDAAAAIAFYKKAFGAEELGRTTQEDGRVGHAELRIGGTVVMVADENPERG---ALSPTKLGGTPVIFHLY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1197475503  94 VNDADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATH 140
Cdd:cd07246    78 VEDVDATFARAVAAGAVVVEPVEDQFWGDRVGKVKDPFGHVWWLATP 124
PhnB COG2764
Zn-dependent glyoxalase, PhnB family [Energy production and conversion];
15-140 4.99e-39

Zn-dependent glyoxalase, PhnB family [Energy production and conversion];


Pssm-ID: 442048 [Multi-domain]  Cd Length: 118  Bit Score: 128.43  E-value: 4.99e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  15 TLTPHIIVAGAAEAIEFYKKAFNAVEQVRLPGPGGKLMHAQLKIGDSTLMLVDEMPDCgngasfgpKELKGTPVVLHLYV 94
Cdd:COG2764     1 SVTPYLVVDDAEEALEFYEDVFGFEVVFRMTDPDGKIMHAELRIGGSVLMLSDAPPDS--------PAAEGNGVSLSLYV 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1197475503  95 NDADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATH 140
Cdd:COG2764    73 DDVDALFARLVAAGATVVMPLQDTFWGDRFGMVRDPFGVLWMINTP 118
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
20-135 1.83e-10

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 55.15  E-value: 1.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  20 IIVAGAAEAIEFYKKAFNA--VEQVRlPGPGGKLMHAQLKIGDSTLMLVDEmpdcGNGASFGPKELKGTPVVLHLYVNDA 97
Cdd:pfam00903   7 LRVGDLEKSLDFYTDVLGFklVEETD-AGEEGGLRSAFFLAGGRVLELLLN----ETPPPAAAGFGGHHIAFIAFSVDDV 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1197475503  98 DATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRW 135
Cdd:pfam00903  82 DAAYDRLKAAGVEIVREPGRHGWGGRYSYFRDPDGNLI 119
PRK10148 PRK10148
VOC family metalloprotein YjdN;
16-141 2.58e-03

VOC family metalloprotein YjdN;


Pssm-ID: 236656  Cd Length: 147  Bit Score: 36.42  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  16 LTPHIIVAG-AAEAIEFYKKAFNA-----VEQVRLPG---------PGGKLM------HAQLKIGDSTLMLVDEMPdcGN 74
Cdd:PRK10148    3 LSPYLSFAGnCADAIAYYQQTLGAellykISFGEMPKsaqdseegcPSGMQFpdtaiaHANVRIAGSDIMMSDAIP--SG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1197475503  75 GASFGpkelkGTPVVLHLYVNDADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATHK 141
Cdd:PRK10148   81 KAHYS-----GFTLVLDTQDVEEGKRWFDNLAANGKIEMAWQETFWAHGFGKVTDKFGVPWMINVVK 142
 
Name Accession Description Interval E-value
VOC_like cd07246
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 14-140 1.19e-44

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


Pssm-ID: 319910 [Multi-domain]  Cd Length: 124  Bit Score: 142.82  E-value: 1.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  14 HTLTPHIIVAGAAEAIEFYKKAFNAVEQVRLPGPGGKLMHAQLKIGDSTLMLVDEMPDCGngaSFGPKELKGTPVVLHLY 93
Cdd:cd07246     1 TTVSPYLVVEDAAAAIAFYKKAFGAEELGRTTQEDGRVGHAELRIGGTVVMVADENPERG---ALSPTKLGGTPVIFHLY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1197475503  94 VNDADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATH 140
Cdd:cd07246    78 VEDVDATFARAVAAGAVVVEPVEDQFWGDRVGKVKDPFGHVWWLATP 124
PhnB COG2764
Zn-dependent glyoxalase, PhnB family [Energy production and conversion];
15-140 4.99e-39

Zn-dependent glyoxalase, PhnB family [Energy production and conversion];


Pssm-ID: 442048 [Multi-domain]  Cd Length: 118  Bit Score: 128.43  E-value: 4.99e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  15 TLTPHIIVAGAAEAIEFYKKAFNAVEQVRLPGPGGKLMHAQLKIGDSTLMLVDEMPDCgngasfgpKELKGTPVVLHLYV 94
Cdd:COG2764     1 SVTPYLVVDDAEEALEFYEDVFGFEVVFRMTDPDGKIMHAELRIGGSVLMLSDAPPDS--------PAAEGNGVSLSLYV 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1197475503  95 NDADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATH 140
Cdd:COG2764    73 DDVDALFARLVAAGATVVMPLQDTFWGDRFGMVRDPFGVLWMINTP 118
PhnB_like cd06588
Escherichia coli PhnB and similar proteins; The Escherichia coli phnB gene is found next to an ...
 16-135 2.13e-14

Escherichia coli PhnB and similar proteins; The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.


Pssm-ID: 319899  Cd Length: 129  Bit Score: 65.76  E-value: 2.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  16 LTPHIIVAG-AAEAIEFYKKAFNAVEQVRL-----------PGPGGKLMHAQLKIGDSTLMLVDEMPDcgngasfgPKEL 83
Cdd:cd06588     1 ITPYLWFNGnAEEALEFYAEVFPGGEILSLtrygegppdfpEGDEGKVMHAEFTLGGQTLMASDDGPG--------FPFT 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1197475503  84 KGTPVVLHLYVNDADATIA--QAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRW 135
Cdd:cd06588    73 FGNAISLSVDCDSQEEADRlfEKLSEGGEVLMPLQETFWGARYGWVKDKFGVSW 126
TioX_like cd08355
Micromonospora sp. TioX and similar proteins; Micromonospora sp. TioX is encoded by a gene of ...
 16-140 2.59e-11

Micromonospora sp. TioX and similar proteins; Micromonospora sp. TioX is encoded by a gene of the thiocoraline biosynthetic gene cluster. Thiocoraline is a thiodepsipeptide with potent antitumor activity. TioX may be involved in thiocoraline resistance or secretion. TioX belongs to vicinal oxygen chelate (VOC) superfamily that is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319943  Cd Length: 123  Bit Score: 57.43  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  16 LTPHIIVAGAAEAIEFYKKAFNAVEQVRLPGPGGKLMHAQLKIGDSTLMLVDEmpDCGNGASFGPKELKGTPVVLHLYVN 95
Cdd:cd08355     1 VVPTLRYRDAVAAIDWLVEAFGFEERMVVPGDEGTIHHAELTFGGGGVMVGSV--RDEARPDRPADAGGHGTQSVYVAVA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1197475503  96 DADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATH 140
Cdd:cd08355    79 DPDAHYERARAAGAEIVMEPTDTDYGSRDYSARDPEGHLWSFGTY 123
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
20-135 1.83e-10

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 55.15  E-value: 1.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  20 IIVAGAAEAIEFYKKAFNA--VEQVRlPGPGGKLMHAQLKIGDSTLMLVDEmpdcGNGASFGPKELKGTPVVLHLYVNDA 97
Cdd:pfam00903   7 LRVGDLEKSLDFYTDVLGFklVEETD-AGEEGGLRSAFFLAGGRVLELLLN----ETPPPAAAGFGGHHIAFIAFSVDDV 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1197475503  98 DATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRW 135
Cdd:pfam00903  82 DAAYDRLKAAGVEIVREPGRHGWGGRYSYFRDPDGNLI 119
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 20-143 3.62e-08

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 49.22  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  20 IIVAGAAEAIEFYKKAFNAVEQVRLPGPGGKLMHAQLKIGDSTLMLVDEMPDcgngasFGPKELKGTPVVLHLYVNDADA 99
Cdd:COG0346     8 LRVSDLEASLAFYTDVLGLELVKRTDFGDGGFGHAFLRLGDGTELELFEAPG------AAPAPGGGGLHHLAFRVDDLDA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1197475503 100 TIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATHKRD 143
Cdd:COG0346    82 AYARLRAAGVEIEGEPRDRAYGYRSAYFRDPDGNLIELVEPPPG 125
PRK10148 PRK10148
VOC family metalloprotein YjdN;
16-141 2.58e-03

VOC family metalloprotein YjdN;


Pssm-ID: 236656  Cd Length: 147  Bit Score: 36.42  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  16 LTPHIIVAG-AAEAIEFYKKAFNA-----VEQVRLPG---------PGGKLM------HAQLKIGDSTLMLVDEMPdcGN 74
Cdd:PRK10148    3 LSPYLSFAGnCADAIAYYQQTLGAellykISFGEMPKsaqdseegcPSGMQFpdtaiaHANVRIAGSDIMMSDAIP--SG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1197475503  75 GASFGpkelkGTPVVLHLYVNDADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFGHRWSVATHK 141
Cdd:PRK10148   81 KAHYS-----GFTLVLDTQDVEEGKRWFDNLAANGKIEMAWQETFWAHGFGKVTDKFGVPWMINVVK 142
VOC_like cd08359
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 16-132 5.52e-03

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319947 [Multi-domain]  Cd Length: 119  Bit Score: 35.07  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197475503  16 LTPHIIVAGAAEAIEFYKKAFNAVEQVRLpgpgGKLMHaqLKIGDSTLMlvdEMPDCGNGASFGPKELKGTP--VVLHLY 93
Cdd:cd08359     3 LGPVIVTEDVAATAAFYVKHFGFRVIFDS----DWYVS--LRRAERHGF---ELAIMDGQHGAVPAASQTQSsgLIINFE 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1197475503  94 VNDADATIAQAAAAGAKVIMPATDMFWGDRYGQVEDPFG 132
Cdd:cd08359    74 VDDADAEYERLTQAGLEFLEPPRDEPWGQRRFIVRDPNG 112
VOC_like cd07251
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 110-138 6.38e-03

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319914 [Multi-domain]  Cd Length: 120  Bit Score: 34.96  E-value: 6.38e-03
                          10        20
                  ....*....|....*....|....*....
gi 1197475503 110 KVIMPATDMFWGDRYGQVEDPFGHRWSVA 138
Cdd:cd07251    90 KILKPPQEVFWGGYSGYFADPDGHIWEVA 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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