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Conserved domains on  [gi|1198278199|gb|OUM45825|]
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undecaprenyl-diphosphatase [Bacillus pseudomycoides]

Protein Classification

undecaprenyl-diphosphatase( domain architecture ID 10130205)

undecaprenyl-diphosphatase catalyzes the dephosphorylation of undecaprenyl diphosphate to undecaprenyl phosphate, includes Bacillus subtilis BcrC and Escherichia coli YbjG

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 24-167 4.17e-60

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


:

Pssm-ID: 239480  Cd Length: 144  Bit Score: 184.38  E-value: 4.17e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  24 LNSTMIFLAEYMVYFLALIIVVYWFTRSNQNRMMIVQAMIAFVTAEIIGKLAGKFHLNYQPFAVLPDVNkLVDHAVDNSF 103
Cdd:cd03385     1 LDALAIFIAEYLIYILPLLLVVLWLWGGEKQRKVVLFATIAVAVALLINYIIGLLYFHPRPFVVGLGHN-LLPHAADSSF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1198278199 104 PSDHTILFFSICFSFWLVRKK-AGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLGSISALFSYW 167
Cdd:cd03385    80 PSDHTTLFFSIAFSLLLRRRKwAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLVFQ 144
 
Name Accession Description Interval E-value
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 24-167 4.17e-60

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 184.38  E-value: 4.17e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  24 LNSTMIFLAEYMVYFLALIIVVYWFTRSNQNRMMIVQAMIAFVTAEIIGKLAGKFHLNYQPFAVLPDVNkLVDHAVDNSF 103
Cdd:cd03385     1 LDALAIFIAEYLIYILPLLLVVLWLWGGEKQRKVVLFATIAVAVALLINYIIGLLYFHPRPFVVGLGHN-LLPHAADSSF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1198278199 104 PSDHTILFFSICFSFWLVRKK-AGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLGSISALFSYW 167
Cdd:cd03385    80 PSDHTTLFFSIAFSLLLRRRKwAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLVFQ 144
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 5-165 2.19e-21

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 86.99  E-value: 2.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199   5 QLNIDAFRAINDLGKQYSFLNSTMIFLAEYMVYFLALIIVVYWFTRSN----QNRMMIVQAMIAFVTAEIIGKLAGKFHL 80
Cdd:PRK11837    4 NLNLSLFSLINATPDSAPWMISLAIFIAKDLILIVPLLAVVLWLWGPRdqltAQRQLVIKIAIALAISLLVSWTIGHLFP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  81 NYQPFAVLPDVNKLvDHAVDNSFPSDH-TILF-FSICFSFWLvRKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLG 158
Cdd:PRK11837   84 HDRPFVEGIGYNFL-HHAADDSFPSDHgTVIFtFALAFLFWH-RLWSGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLVG 161


                  ....*..
gi 1198278199 159 SISALFS 165
Cdd:PRK11837  162 MIGCLSA 168
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 1-171 1.68e-20

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 84.32  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199   1 MSFSQLNIDAFRAINDLGKQYSFLNSTMIFLAEYMVYFLALIIVVYWFTRSNQNRMMIVQAMIAFVTAEIIGKLAGKFHL 80
Cdd:COG0671    15 LLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  81 NYQ---PFAVlPDVNKLVDHAVDNSFPSDHTILFFSICFSFWLV--RKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGA 155
Cdd:COG0671    95 LFGrprPFVV-PDLELLLGTAGGYSFPSGHAAAAFALALVLALLlpRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGA 173

                         170
                  ....*....|....*.
gi 1198278199 156 LLGSISALFSYWLTPK 171
Cdd:COG0671   174 LLGLAIALLLLALLRR 189
acidPPc smart00014
Acid phosphatase homologues;
62-164 1.62e-15

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 69.30  E-value: 1.62e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199   62 MIAFVTAEIIGKLAGKFHLNYQPFAVLPD-----VNKLVDHAVDNSFPSDHTI------LFFSICFSFWLVRKKAGWLWL 130
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGdacctPNFLLTLEAGYSFPSGHTAfafafaLFLLLYLPARAGRKLLIFLLL 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1198278199  131 VLAFCVAISRIWVGVHYPFDVVTGALLGSISALF 164
Cdd:smart00014  81 LLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAV 114
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 89-171 1.11e-13

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 64.75  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  89 PDVNKLVDHAVDNSFPSDHT--------ILFFSICFSFWLVRKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLGSI 160
Cdd:pfam01569  34 LVPAPSTLPGLGYSFPSGHSatafalalLLALLLRRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGIL 113

                          90
                  ....*....|.
gi 1198278199 161 SALFSYWLTPK 171
Cdd:pfam01569 114 LALLVYRLVPK 124
 
Name Accession Description Interval E-value
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 24-167 4.17e-60

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 184.38  E-value: 4.17e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  24 LNSTMIFLAEYMVYFLALIIVVYWFTRSNQNRMMIVQAMIAFVTAEIIGKLAGKFHLNYQPFAVLPDVNkLVDHAVDNSF 103
Cdd:cd03385     1 LDALAIFIAEYLIYILPLLLVVLWLWGGEKQRKVVLFATIAVAVALLINYIIGLLYFHPRPFVVGLGHN-LLPHAADSSF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1198278199 104 PSDHTILFFSICFSFWLVRKK-AGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLGSISALFSYW 167
Cdd:cd03385    80 PSDHTTLFFSIAFSLLLRRRKwAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLVFQ 144
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 5-165 2.19e-21

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 86.99  E-value: 2.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199   5 QLNIDAFRAINDLGKQYSFLNSTMIFLAEYMVYFLALIIVVYWFTRSN----QNRMMIVQAMIAFVTAEIIGKLAGKFHL 80
Cdd:PRK11837    4 NLNLSLFSLINATPDSAPWMISLAIFIAKDLILIVPLLAVVLWLWGPRdqltAQRQLVIKIAIALAISLLVSWTIGHLFP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  81 NYQPFAVLPDVNKLvDHAVDNSFPSDH-TILF-FSICFSFWLvRKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLG 158
Cdd:PRK11837   84 HDRPFVEGIGYNFL-HHAADDSFPSDHgTVIFtFALAFLFWH-RLWSGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLVG 161


                  ....*..
gi 1198278199 159 SISALFS 165
Cdd:PRK11837  162 MIGCLSA 168
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 1-171 1.68e-20

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 84.32  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199   1 MSFSQLNIDAFRAINDLGKQYSFLNSTMIFLAEYMVYFLALIIVVYWFTRSNQNRMMIVQAMIAFVTAEIIGKLAGKFHL 80
Cdd:COG0671    15 LLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  81 NYQ---PFAVlPDVNKLVDHAVDNSFPSDHTILFFSICFSFWLV--RKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGA 155
Cdd:COG0671    95 LFGrprPFVV-PDLELLLGTAGGYSFPSGHAAAAFALALVLALLlpRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGA 173

                         170
                  ....*....|....*.
gi 1198278199 156 LLGSISALFSYWLTPK 171
Cdd:COG0671   174 LLGLAIALLLLALLRR 189
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 61-166 1.32e-17

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 74.80  E-value: 1.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  61 AMIAFVTAEIIGKLAGKFHLN----YQPFAVLPDVNKLVDHAVDNSFPSDHTILFFSICFSFWL------VRKKAGWLWL 130
Cdd:cd01610     7 LLLLALLAGLLLTGVLKYLFGrprpYFLLRCGPDGDPLLLTEGGYSFPSGHAAFAFALALFLALllprrlLRLLLGLLLL 86

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1198278199 131 VLAFCVAISRIWVGVHYPFDVVTGALLGSISALFSY 166
Cdd:cd01610    87 LLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
acidPPc smart00014
Acid phosphatase homologues;
62-164 1.62e-15

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 69.30  E-value: 1.62e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199   62 MIAFVTAEIIGKLAGKFHLNYQPFAVLPD-----VNKLVDHAVDNSFPSDHTI------LFFSICFSFWLVRKKAGWLWL 130
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGdacctPNFLLTLEAGYSFPSGHTAfafafaLFLLLYLPARAGRKLLIFLLL 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1198278199  131 VLAFCVAISRIWVGVHYPFDVVTGALLGSISALF 164
Cdd:smart00014  81 LLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAV 114
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 89-171 1.11e-13

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 64.75  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  89 PDVNKLVDHAVDNSFPSDHT--------ILFFSICFSFWLVRKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLGSI 160
Cdd:pfam01569  34 LVPAPSTLPGLGYSFPSGHSatafalalLLALLLRRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGIL 113

                          90
                  ....*....|.
gi 1198278199 161 SALFSYWLTPK 171
Cdd:pfam01569 114 LALLVYRLVPK 124
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 101-166 1.32e-12

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 63.11  E-value: 1.32e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1198278199 101 NSFPSDHTILFFSICFSFWLVRKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLGSISALFSY 166
Cdd:cd03389   118 TSFPSGHSATAGAAAAALALLFPRYRWAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALY 183
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 102-168 4.47e-12

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 61.51  E-value: 4.47e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1198278199 102 SFPSDHTILFFSICFSFWLVRKKAGWLW--LVLAFCVAISRIWVGVHYPFDVVTGALLGSISALFSYWL 168
Cdd:cd03395   105 SFASSHAANSFALALFIWLFFRRGLFSPvlLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYLL 173
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 8-172 5.00e-12

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 61.47  E-value: 5.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199   8 IDAFRAINDLGKQYSFLNSTMIFLAEYMVYFLALIIVVYWFTRsnqNRMMIVQAMIAFVTAEIIGKLAGKFhlnyqpFAV 87
Cdd:cd03392    17 LSLLRSLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKR---RRRAALFLLLALLGGGALNTLLKLL------VQR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  88 LPDVNKLVDHAVDNSFPSDH----TILFFSICFSFWLVRKK------AGWLWLVLAFCVAISRIWVGVHYPFDVVTGALL 157
Cdd:cd03392    88 PRPPLHLLVPEGGYSFPSGHamgaTVLYGFLAYLLARRLPRrrvrilLLILAAILILLVGLSRLYLGVHYPSDVLAGWLL 167

                         170
                  ....*....|....*
gi 1198278199 158 GSISALFSYWLTPKI 172
Cdd:cd03392   168 GLAWLALLILLYRRL 182
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 102-166 5.59e-08

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 50.68  E-value: 5.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199 102 SFPSDHTILFFSIC--FSFWLVRK-----KAGWLW--------LVLAFCVAISRIWVGVHYPFDVVTGALLGSISALFSY 166
Cdd:cd03390   111 SFPSGHSSFAFAGLgfLSLYLAGKlhifdPRGSSWrlllallpLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSY 190
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 100-169 1.04e-07

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 48.10  E-value: 1.04e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1198278199 100 DNSFPSDHTILFFSiCFSFwlVRKKAGWLW-----LVLAFCVAISRIWVGVHYPFDVVTGALLGSisaLFSYWLT 169
Cdd:cd03394    38 YRSFPSGHTASAFA-AATF--LQYRYGWRWygipaYALASLVGASRVVANRHWLSDVLAGAAIGI---LVGYLVT 106
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 81-158 2.88e-07

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 48.96  E-value: 2.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  81 NYQPFAVLPDvnklvdHAvdnSFPSDH--------TIL--FFSICFSFWLVRKKAGWLWLV-----------LAFCVAIS 139
Cdd:cd03398   134 YWLPLAGTPP------HP---SYPSGHatfagaaaTVLkaLFGSDKVPDTVSEPDEGGPSTgvtrvwaelneLADEVAIS 204

                          90
                  ....*....|....*....
gi 1198278199 140 RIWVGVHYPFDVVTGALLG 158
Cdd:cd03398   205 RVYAGVHFRSDDAAGAALG 223
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 77-159 2.91e-07

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 48.97  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  77 KFHLNYQ-PFAVLPDVNKLVDHAVDN-----SFPSDHTIlffsicfsfwlvrkkAGWLW-LVLAFCV------------- 136
Cdd:cd03380   113 KYHYNRPrPFVAIRLQWLPICTPEEGtpkhpSYPSGHAT---------------FGGAAaLVLAELFperaaellaraae 177

                          90       100
                  ....*....|....*....|....
gi 1198278199 137 -AISRIWVGVHYPFDVVTGALLGS 159
Cdd:cd03380   178 aGNSRVVAGVHWPSDVEAGRILGE 201
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 92-165 1.48e-06

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 46.16  E-value: 1.48e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1198278199  92 NKLVDHAVDN-SFPSDHTILFFSICFSFWLVRKKAGWLWLVL---AFCVAISRIWVGVHYPFDVVTGALLGSISALFS 165
Cdd:cd03391    81 DMLDYVAVDKySFPSGHASRAAFVARFLLNHLVLAVPLRVLLvlwATVVGISRVLLGRHHVLDVLAGAFLGYLEALLV 158
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 96-164 2.35e-06

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 45.30  E-value: 2.35e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1198278199  96 DHAVDNSFPSDHTILFFSICFSF----WLVRKKAGWLWLVLAFC----VAISRIWVGVHYPFDVVTGALLGSISALF 164
Cdd:cd03388    73 SAALEYGFPSTHAMNATAISFYLliylYDRYQYPFVLGLILALFystlVCLSRIYMGMHSVLDVIAGSLIGVLILLF 149
PAP2_3 pfam14378
PAP2 superfamily;
101-164 1.66e-05

PAP2 superfamily;


Pssm-ID: 433919  Cd Length: 190  Bit Score: 43.48  E-value: 1.66e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1198278199 101 NSFPSDHTI--LFFSICFSFWLVRKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLGSISALF 164
Cdd:pfam14378 125 AAMPSLHVAwaLLCALALWRLRRTRILRWLAVAYNVLMIVSTVATGNHYLLDVVAGVALALAAIAL 190
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 75-159 3.49e-05

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 43.09  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  75 AGKFHLNY-QPFAVLPDVNKLVDH----AVDNSFPSDHTilffsicfsfwlvrkKAGWLW-LVLAFCV-----AI----- 138
Cdd:cd03397   119 PAKKYYNRpRPFVLNDEPICTPPDesglAKDGSYPSGHT---------------AAGYAWaLILAELVperadEIlargs 183

                          90       100
                  ....*....|....*....|....*
gi 1198278199 139 ----SRIWVGVHYPFDVVTGALLGS 159
Cdd:cd03397   184 eygqSRIVCGVHWPSDVMGGRIMAA 208
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 102-158 2.08e-04

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 39.66  E-value: 2.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199 102 SFPSDHTILFFSICFSFWLVRKKAgWLWL---VLAFCVAISRIWVGVHYPFDVVTGALLG 158
Cdd:cd03393    59 GFPSGHAQTSATFWGSLMLHVRKK-WFTLigvVLVVLISFSRLYLGVHWPSDVIGGVLIG 117
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 102-164 2.42e-04

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 39.92  E-value: 2.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1198278199 102 SFPSDHTIL-FFSICFSFWLVRKKAGWLW------------LVLAFCVAISRIWVGVHYPFDVVTGALLGSISALF 164
Cdd:cd03384    73 SFPSGHASLsMYAAVFLALYLQARLKLRGsrllrpllqfllLALALYVGLSRISDYKHHWSDVLAGALLGSVIALF 148
PAP2_Aur1_like cd03386
PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of ...
 101-167 7.85e-04

PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.


Pssm-ID: 239481  Cd Length: 186  Bit Score: 38.83  E-value: 7.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1198278199 101 NSFPSDHTIL-FFSICFSFWLVRKKAGWLWLVLAFCVAISRIWVGVHYPFDVVTGALLGSISALFSYW 167
Cdd:cd03386   117 NAFPSLHVAWaVLAALFLWRHRRRLLRWLAVLWPLLIWLSTLYLGNHYFIDLVGGIALALLSFYLARR 184
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 101-168 3.32e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 36.89  E-value: 3.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1198278199 101 NSFPSDHTILFFSICFSFWLVRK---KAGWLWLVLAFC----VAISRIWVGVHYPFDVVTGALLGSISALFSYWL 168
Cdd:cd03396   122 CSFPSGHASAGFALLALYFLFRRrrpRLARLVLAAGLAlgalMGLARMARGAHFLSDVLWSLLLVWLIALLLYRL 196
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 96-191 9.79e-03

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 36.25  E-value: 9.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198278199  96 DHAVDNSFPSDHTIlfFSICFSFWLVRKKAGWL--------WLVLA-FC-----VAISRIWVGVHYPFDVVTGALLGsiS 161
Cdd:PLN02525   79 ENAMEYGLPSSHTL--NTVCLSGYLLHYVLSYLqnvdasviFAGLAlFCllvalVGFGRLYLGMHSPIDIIAGLAIG--L 154

                          90       100       110
                  ....*....|....*....|....*....|
gi 1198278199 162 ALFSYWLTpkitfIKELLKLYEKMEQNVLP 191
Cdd:PLN02525  155 VILAFWLT-----VDEYVDAFITSGQNVTP 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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