BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960  255 ADVIFLCgDGGRVKAHRIILATQYKLLTTAFIDQPAHEISMVSVPDITSDTMKLIILLAYKSDVVINSDQIEKMKDFFEM 334
Cdd:cd18315      2 VDVTLAC-EGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                   ....*
gi 1215269960  335 FGIDF 339
Cdd:cd18315     81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960  255 ADVIFLCgDGGRVKAHRIILATQYKLLTTAFIDQPAHEISMVSVPDITSDTMKLIILLAYKSDVVINSDQIEKMKDFFEM 334
Cdd:cd18315      2 VDVTLAC-EGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                   ....*
gi 1215269960  335 FGIDF 339
Cdd:cd18315     81 LQIKG 85

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960  256 DVIFLCGDGgRVKAHRIILATQ----YKLLTTAFIDqpaHEISMVSVPDITSDTMKLIILLAYkSDVVINSDQIEK---M 328
Cdd:pfam00651   12 DVTLVVGDK-EFRAHKAVLAACspyfKALFSGQESE---SSVSEITLDDVSPEDFEALLEFMY-TGKLISEENVDDllaA 86

                   ....*.
gi 1215269960  329 KDFFEM 334
Cdd:pfam00651   87 ADKLQI 92

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960  255 ADVIFLCgDGGRVKAHRIILATQYKLLTTAFIDQPAHEISMVSVPDITSDTMKLIILLAYKSDVVINSDQIEKMKDFFEM 334
Cdd:cd18315      2 VDVTLAC-EGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                   ....*
gi 1215269960  335 FGIDF 339
Cdd:cd18315     81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960  256 DVIfLCGDGGRVKAHRIILA--TQY--KLLTTAFIDQPAHEISmvsVPDITSDTMKLIILLAYKSDVVINSDQIEKM--- 328
Cdd:cd18240     19 DVV-IRVNGVEFPAHRNILCacSPYfrALFTNGWNETEKKVYK---IPGVSPEMMELIIEYAYTRTVPITAENVEELlpa 94

                           90       100
                   ....*....|....*....|....*
gi 1215269960  329 KDFFEMFGI-----DF--SNLAVES 346
Cdd:cd18240     95 ADQFNIMGIvkaccDFleDQLCPEN 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960  256 DVIFLCgDGGRVKAHRIILATQ----YKLLTTAFIDQPAHEismVSVPDITSDTMKLIILLAYKSDVVINSDQIEKMKDF 331
Cdd:cd18237     23 DVILIV-EGREIKAHRVVLAAAshffHLMFTSNMTESKSSE---VELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDA 98

                   ....*...
gi 1215269960  332 FEMFGIDF 339
Cdd:cd18237     99 ANQYQIEP 106

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960  255 ADVIFLCGDGGRVKAHRIILATQ----YKLLTTafidqpahEISMVSVPDITSDTMKLIILLAYKSDVVINSDQIEKMK- 329
Cdd:cd18299     13 ADVVFILQGGVRIFAHRIVLAAAssvfADLFLM--------MTVVTLDSDITPEAFRRVLEFLYTGVLDENEDDLKELKd 84

                   ....*...
gi 1215269960  330 --DFFEMF 335
Cdd:cd18299     85 aaELLELF 92

Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960 1119 KPKRGGKAAAKTNKQARG---------VEKAESEG----VLTPGEGSKNDTESIEDNSAQSKGDdvPETTEELGRTDEKD 1185
Cdd:pfam05793  246 KLAKNKKKLDDDKKKKRGgdddafeydSDDGDDEGreedYISDSSASGNDPEEREDKLSPEEPA--KGEIEQSDDSEESE 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215269960 1186 DDGIELDQDEEAP-MDVTDSTTVTTTDTSHDDDDSKTEDVSQIDDENDN----------DEKERDDDDADAIMGEIKSAT 1254
Cdd:pfam05793  324 EEKNEEEGKLSKKgKKAKKLKGKKNGKDKSESSDGDDSDDSDIDDEDSVplftakkkkePKKEEPVDSGPSSPGNSGPAR 403

                   ....*...
gi 1215269960 1255 PPPPPGET 1262
Cdd:pfam05793  404 PSPESGST 411