|
Name |
Accession |
Description |
Interval |
E-value |
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
42-289 |
7.01e-66 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 207.44 E-value: 7.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 42 FLEGPATDTQGNLFVVDVPYGRILRCELKSREWEVLADFDGEANGLALNEEGELIVADYKNGLMKCDPRTGKVDPILLRR 121
Cdd:COG3386 9 LGEGPVWDPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPADGEVTVLADEY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 122 NmERFKGLNDVIVARNGDIYFTDqgqTGMTDQTGLVYRLSPNGKLDTLLCNGISPNGLVLNPEETVLYVAMTRDNSVWRL 201
Cdd:COG3386 89 G-KPLNRPNDGVVDPDGRLYFTD---MGEYLPTGALYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 202 PLHSDGTTTKAAKFFT-SFGIAGPDGLTVDEEGNLFICHPSLLSIFVVTKHGIPLARIVPPGEHgtsVTNCIFGStkEDR 280
Cdd:COG3386 165 DLDADGTLGNRRVFADlPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDPDGELLGRIELPERR---PTNVAFGG--PDL 239
|
....*....
gi 1218458574 281 NRLYFTDST 289
Cdd:COG3386 240 RTLYVTTAR 248
|
|
| SGL |
pfam08450 |
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ... |
44-286 |
2.13e-35 |
|
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.
Pssm-ID: 462480 [Multi-domain] Cd Length: 246 Bit Score: 128.15 E-value: 2.13e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 44 EGPATDTQGN-LFVVDVPYGRILRCELKSREwEVLADFDGEANGLALNEEGELIVADyKNGLMKCDPRTGKVDPIL-LRR 121
Cdd:pfam08450 3 EGPVWDEEEGaLYWVDILGGRIHRLDPATGK-ETVWDTPGPVGAIAPRDDGGLIVAL-KDGVALLDLATGELTPLAdPED 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 122 NMERFKGLNDVIVARNGDIYFTDQGQTGMTDQ-TGLVYRLSPNGKLDTLLCNGISPNGLVLNPEETVLYVAMTRDNSVWR 200
Cdd:pfam08450 81 DDWPLNRFNDGKVDPDGRFWFGTMGDDEAPGGdPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKIWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 201 LPLHSDGTTTKAAKFFTSFGIAG--PDGLTVDEEGNLFICHPSLLSIFVVTKHGIPLARIVPPGEHgtsVTNCIFGStkE 278
Cdd:pfam08450 161 YDYDLDGGLISNRRVFADFKPGLgrPDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKR---PTSCAFGG--P 235
|
....*...
gi 1218458574 279 DRNRLYFT 286
Cdd:pfam08450 236 DLRTLYVT 243
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
34-293 |
2.81e-14 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 71.58 E-value: 2.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 34 GSGAPPKIFLEGPATDTQGNLFVVDVPYGRILRCELKSRE---WEVLADFDGEAN---GLALNEEGELIVADYKNGLM-K 106
Cdd:cd05819 1 GTGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFitsFGSFGSGDGQFNepaGVAVDSDGNLYVADTGNHRIqK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 107 CDPRTGKVDPILLR-RNMERFKGLNDVIVARNGDIYFTDQGQtgmtDQtglVYRLSPNGKLDTLLCNGIS-------PNG 178
Cdd:cd05819 81 FDPDGNFLASFGGSgDGDGEFNGPRGIAVDSSGNIYVADTGN----HR---IQKFDPDGEFLTTFGSGGSgpgqfngPTG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 179 LVLNPEETVlYVAMTRDNSVWRLPlhSDGTttkaakFFTSFGIAG--------PDGLTVDEEGNLFICHPSLLSIFVVTK 250
Cdd:cd05819 154 VAVDSDGNI-YVADTGNHRIQVFD--PDGN------FLTTFGSTGtgpgqfnyPTGIAVDSDGNIYVADSGNNRVQVFDP 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1218458574 251 HGiplARIVPPGEHGTSVT--NCIFGSTKEDRNRLYFTDSTIGRI 293
Cdd:cd05819 225 DG---AGFGGNGNFLGSDGqfNRPSGLAVDSDGNLYVADTGNNRI 266
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
17-293 |
4.49e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 68.12 E-value: 4.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 17 SSVPITLWstkttdWLPGSGAPPkiflEGPATDTQGNLFVVDVPYGRILRCELKSREWEVLADFDGEA-NGLALNEEGEL 95
Cdd:COG4257 3 SAVDITEY------PVPAPGSGP----RDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGpHGIAVDPDGNL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 96 IVADYKNGLM-KCDPRTGKVDPILLRrnmERFKGLNDVIVARNGDIYFTDQGqtgmtdqTGLVYRLSP-NGKLDT--LLC 171
Cdd:COG4257 73 WFTDNGNNRIgRIDPKTGEITTFALP---GGGSNPHGIAFDPDGNLWFTDQG-------GNRIGRLDPaTGEVTEfpLPT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 172 NGISPNGLVLNPEETVlYVAMTRDNSVWRLplhsDGTTTKAAKFFTSFGIAGPDGLTVDEEGNLFICHPSLLSIFV---- 247
Cdd:COG4257 143 GGAGPYGIAVDPDGNL-WVTDFGANAIGRI----DPDTGTLTEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRfdpk 217
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1218458574 248 ---VTKHGIPLARIVPpgeHGTSVTncifgstkeDRNRLYFTDSTIGRI 293
Cdd:COG4257 218 tgtVTEYPLPGGGARP---YGVAVD---------GDGRVWFAESGANRI 254
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
45-237 |
2.13e-11 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 62.61 E-value: 2.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 45 GPATDTQGNLFVVDVPYGRILRCELKSREWEVLAdFDG--EANGLALNEEGELIVADYKNG-LMKCDPrtGKVDPILLrr 121
Cdd:cd14952 14 GVAVDAAGNVYVADSGNNRVLKLAAGSTTQTVLP-FTGlyQPQGVAVDAAGTVYVTDFGNNrVLKLAA--GSTTQTVL-- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 122 nmeRFKGLND---VIVARNGDIYFTDQGQ-------TGMTDQTGLvyrlsPNGKLDtllcngiSPNGLVLNPEETVlYVA 191
Cdd:cd14952 89 ---PFTGLNDptgVAVDAAGNVYVADTGNnrvlklaAGSNTQTVL-----PFTGLS-------NPDGVAVDGAGNV-YVT 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1218458574 192 MTRDNSVWRLPLhsdGTTTKAAKFFTsfGIAGPDGLTVDEEGNLFI 237
Cdd:cd14952 153 DTGNNRVLKLAA---GSTTQTVLPFT--GLNSPSGVAVDTAGNVYV 193
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
33-237 |
4.23e-07 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 50.28 E-value: 4.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 33 PGSGAPPKI-F--LEGP---ATDTQGNLFVVDVPYGRILRCELKSREWEVLAdFDG--EANGLALNEEGELIVADY-KNG 103
Cdd:cd14952 38 AGSTTQTVLpFtgLYQPqgvAVDAAGTVYVTDFGNNRVLKLAAGSTTQTVLP-FTGlnDPTGVAVDAAGNVYVADTgNNR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 104 LMKCDPRTGKvdPILLRrnmerFKGLN---DVIVARNGDIYFTDQGQ-------TGMTDQTGLvyrlsPNGKLDtllcng 173
Cdd:cd14952 117 VLKLAAGSNT--QTVLP-----FTGLSnpdGVAVDGAGNVYVTDTGNnrvlklaAGSTTQTVL-----PFTGLN------ 178
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1218458574 174 iSPNGLVLNPEETVlYVAMTRDNSVWRLPlhsDGTTTKAAKFFTsfGIAGPDGLTVDEEGNLFI 237
Cdd:cd14952 179 -SPSGVAVDTAGNV-YVTDHGNNRVLKLA---AGSTTPTVLPFT--GLNGPLGVAVDAAGNVYV 235
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
86-238 |
9.38e-07 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 49.13 E-value: 9.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 86 GLALNEEGELIVADYKNG-LMKCdpRTGKVDPILLRrnmerFKGLND---VIVARNGDIYFTDQGQT-------GMTDQT 154
Cdd:cd14952 14 GVAVDAAGNVYVADSGNNrVLKL--AAGSTTQTVLP-----FTGLYQpqgVAVDAAGTVYVTDFGNNrvlklaaGSTTQT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 155 GLvyrlsPNGKLDtllcngiSPNGLVLNPEETVlYVAMTRDNSVWRLPlhsDGTTTKAAKFFTsfGIAGPDGLTVDEEGN 234
Cdd:cd14952 87 VL-----PFTGLN-------DPTGVAVDAAGNV-YVADTGNNRVLKLA---AGSNTQTVLPFT--GLSNPDGVAVDGAGN 148
|
....
gi 1218458574 235 LFIC 238
Cdd:cd14952 149 VYVT 152
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
38-198 |
9.68e-06 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 46.13 E-value: 9.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 38 PPKIFLEGPATDT--QGNLFVVDVPYGRILRCELKS---REWEVLADFDGE---ANGLALNEEGELIVADYKNGLMKCDP 109
Cdd:cd14963 96 KDRVKLISPAGLAidDGKLYVSDVKKHKVIVFDLEGkllLEFGKPGSEPGElsyPNGIAVDEDGNIYVADSGNGRIQVFD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 110 RTGKvdpillrrNMERFKGLND----------VIVARNGDIYFTDQgqtgMTDQtglVYRLSPNGKLDTLLcnGIS---- 175
Cdd:cd14963 176 KNGK--------FIKELNGSPDgksgfvnprgIAVDPDGNLYVVDN----LSHR---VYVFDEQGKELFTF--GGRgkdd 238
|
170 180
....*....|....*....|....*...
gi 1218458574 176 -----PNGLVLNPEEtVLYVAMTRDNSV 198
Cdd:cd14963 239 gqfnlPNGLFIDDDG-RLYVTDRENNRV 265
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
44-238 |
1.52e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 45.74 E-value: 1.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 44 EGPATDTQGNLFVVDVPYGRI----LRCELKSREWEVlADFDGEA---NGLALNEEGELIVADYKNGLMKCDPRTGKVDP 116
Cdd:cd14956 16 RGIAVDADDNVYVADARNGRIqvfdKDGTFLRRFGTT-GDGPGQFgrpRGLAVDKDGWLYVADYWGDRIQVFTLTGELQT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 117 ILLRRNME--RFKGLNDVIVARNGDIYFTDQGqtgmtdqTGLVYRLSPNGK-LDTLLCNGI------SPNGLVLNPEETv 187
Cdd:cd14956 95 IGGSSGSGpgQFNAPRGVAVDADGNLYVADFG-------NQRIQKFDPDGSfLRQWGGTGIepgsfnYPRGVAVDPDGT- 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1218458574 188 LYVAMTRDNSVWRLP-----LHSDGTTTKAAKFFTSfgiagPDGLTVDEEGNLFIC 238
Cdd:cd14956 167 LYVADTYNDRIQVFDndgafLRKWGGRGTGPGQFNY-----PYGIAIDPDGNVFVA 217
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
86-238 |
3.03e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 44.89 E-value: 3.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 86 GLALNEEGELIVADYKNGLMKC-DPRTGKVDPILlRRNMERFKGLNDVIVARNGDIYFTDQGqtgmtdqTGLVYRLSPNG 164
Cdd:cd14962 16 GVAADGRGRIYVADTGRGAVFVfDLPNGKVFVIG-NAGPNRFVSPIGVAIDANGNLYVSDAE-------LGKVFVFDRDG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 165 KLDTLLCNGI---SPNGLVLNPEETVLYVAMTRDNSVW----------------------RLPLH----SDGTT------ 209
Cdd:cd14962 88 KFLRAIGAGAlfkRPTGIAVDPAGKRLYVVDTLAHKVKvfdldgrllfdigkrgsgpgefNLPTDlavdRDGNLyvtdtm 167
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1218458574 210 -------TKAAKFFTSFGIAG--------PDGLTVDEEGNLFIC 238
Cdd:cd14962 168 nfrvqifDADGKFLRSFGERGdgpgsfarPKGIAVDSEGNIYVV 211
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
33-237 |
4.77e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.20 E-value: 4.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 33 PGSGAPPKIFLEGPATDTQGNLFVVDVPYGRIlrcELKSREWEVLADFDGEANGLALN-------EEGELIVADYKNGLM 105
Cdd:cd14963 48 PGTGPGEFKYPYGIAVDSDGNIYVADLYNGRI---QVFDPDGKFLKYFPEKKDRVKLIspaglaiDDGKLYVSDVKKHKV 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 106 KCDPRTGKvdpiLLR------RNMERFKGLNDVIVARNGDIYFTDQGqtgmtdqTGLVYRLSPNGK-LDTLLCNGISPNG 178
Cdd:cd14963 125 IVFDLEGK----LLLefgkpgSEPGELSYPNGIAVDEDGNIYVADSG-------NGRIQVFDKNGKfIKELNGSPDGKSG 193
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1218458574 179 LVlNP------EETVLYVAMTRDNSVwrLPLHSDGtttkaaKFFTSFGIAG--------PDGLTVDEEGNLFI 237
Cdd:cd14963 194 FV-NPrgiavdPDGNLYVVDNLSHRV--YVFDEQG------KELFTFGGRGkddgqfnlPNGLFIDDDGRLYV 257
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
44-202 |
7.80e-05 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 43.35 E-value: 7.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 44 EGPATDTQGNLFVVDVPYGRILRCELKSREWEVLaDFDG--EANGLALNEEGELIVAD-YKNGLMKCDPrtGKVDPILLr 120
Cdd:cd14952 97 TGVAVDAAGNVYVADTGNNRVLKLAAGSNTQTVL-PFTGlsNPDGVAVDGAGNVYVTDtGNNRVLKLAA--GSTTQTVL- 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 121 rnmeRFKGLND---VIVARNGDIYFTDQGQ-------TGMTDQTGLvyrlsPNGKLDTllcngisPNGLVLNPEETVlYV 190
Cdd:cd14952 173 ----PFTGLNSpsgVAVDTAGNVYVTDHGNnrvlklaAGSTTPTVL-----PFTGLNG-------PLGVAVDAAGNV-YV 235
|
170
....*....|..
gi 1218458574 191 AMTRDNSVWRLP 202
Cdd:cd14952 236 ADRGNDRVVKLP 247
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
15-201 |
1.51e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 42.65 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 15 TFSSVPITLWSTkttdwlPGSGAPPKIFLEGPATDTQGNLFVVDVPYGRILRCELKS---REWEVLADFDGEAN---GLA 88
Cdd:cd14956 87 TLTGELQTIGGS------SGSGPGQFNAPRGVAVDADGNLYVADFGNQRIQKFDPDGsflRQWGGTGIEPGSFNyprGVA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 89 LNEEGELIVADYKNGLMKCDPRTGKvdpiLLRRNMERFKGLN------DVIVARNGDIYFTDQGQtgmtdqtGLVYRLSP 162
Cdd:cd14956 161 VDPDGTLYVADTYNDRIQVFDNDGA----FLRKWGGRGTGPGqfnypyGIAIDPDGNVFVADFGN-------NRIQKFTA 229
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1218458574 163 NGKL-------DTLLCNGISPNGLVLNPEETVlYVAMTRDNSVWRL 201
Cdd:cd14956 230 DGTFltswgspGTGPGQFKNPWGVVVDADGTV-YVADSNNNRVQRF 274
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
10-234 |
2.81e-04 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 41.60 E-value: 2.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 10 VVTARTFSSVPITLWSTKTTDWLPGSGAPPKIFLEGPATDTQGNLFVVDVPYGRILRCELKSREWEVLADFDGEANGlal 89
Cdd:COG3391 3 VASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADG--- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 90 neeGELIVADYKNG-LMKCDPRTGKVdpillRRNMERFKGLNDVIVARNGD-IYFTDQGqtgmtdqTGLVYRLSP-NGKL 166
Cdd:COG3391 80 ---RRLYVANSGSGrVSVIDLATGKV-----VATIPVGGGPRGLAVDPDGGrLYVADSG-------NGRVSVIDTaTGKV 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1218458574 167 DTLLCNGISPNGLVLNPEETVLYVAMTRDNSVWRLPLHSDGTTTKAAKFFTSFGiaGPDGLTVDEEGN 234
Cdd:COG3391 145 VATIPVGAGPHGIAVDPDGKRLYVANSGSNTVSVIVSVIDTATGKVVATIPVGG--GPVGVAVSPDGR 210
|
|
| COG3292 |
COG3292 |
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; |
47-238 |
3.52e-04 |
|
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
Pssm-ID: 442521 [Multi-domain] Cd Length: 924 Bit Score: 42.28 E-value: 3.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 47 ATDTQGNLFVVDvpYGRILRCELKSREWEVLAD-----------FDGEANGLALNEEGELIVADYKNGLMKCDPRTGKVD 115
Cdd:COG3292 130 AEDSDGNIWVGT--SNGLYRYDPKTGKFKRFTLdglpsntitslAEDADGNLWVDSDGNLWIGTDGNGLYRLDPNTGKFE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 116 PILLRRNMERFKG--LNDVIVARNGDIYFTdqgqtgmTDQTGLvYRLSPNGKLDTLLCNGiSPNGLvlnPEETVLYVAMT 193
Cdd:COG3292 208 HITHDPDPNSLSSnsIYSLFEDREGNLWVG-------TYGGGL-NYLDPNNSKFKSYRHN-DPNGL---SGNSVRSIAED 275
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1218458574 194 RDNSVW-RLPL--HSDG-----TTTKAAKFFTSFGIAGPD--GLTVDEEGNLFIC 238
Cdd:COG3292 276 SDGNLWiRLWIgtYGGGlfrldPKTGKFKRYNPNGLPSNSvySILEDSDGNLWIG 330
|
|
| NHL_TRIM32_like |
cd14961 |
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ... |
36-102 |
3.99e-04 |
|
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271331 [Multi-domain] Cd Length: 273 Bit Score: 41.11 E-value: 3.99e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1218458574 36 GAPPKIFLEGPATDTQGNLFVVDVPYGRILrCELKSREWEVLADFDGEA----NGLALNEEGELIVADYKN 102
Cdd:cd14961 197 VFPSLICASGVAFDSEGNVIVADTGSGAIL-CLGKPEGFPILKPIVTQGlsrpVGLAVTPDGSLVVLDSGN 266
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
175-297 |
4.11e-04 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 41.15 E-value: 4.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 175 SPNGLVLNPEETVlYVAMTRDNSVWRLPlhSDGTttkaakFFTSFGIAG--------PDGLTVDEEGNLFICHPSLLSIF 246
Cdd:cd05819 9 NPQGIAVDSSGNI-YVADTGNNRIQVFD--PDGN------FITSFGSFGsgdgqfnePAGVAVDSDGNLYVADTGNHRIQ 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1218458574 247 VVTKHGIPLARIVPPGEhGTSVTNCIFGSTKEDRNRLYFTDSTIGRICYVD 297
Cdd:cd05819 80 KFDPDGNFLASFGGSGD-GDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFD 129
|
|
| COG3292 |
COG3292 |
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; |
47-235 |
4.83e-04 |
|
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
Pssm-ID: 442521 [Multi-domain] Cd Length: 924 Bit Score: 41.90 E-value: 4.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 47 ATDTQGNLFV---VDVPYGRILRCELKSREWEVLADF---DGEANGLALNEEGELIVADYKNGLMKCDPRTGKVDPILLR 120
Cdd:COG3292 273 AEDSDGNLWIrlwIGTYGGGLFRLDPKTGKFKRYNPNglpSNSVYSILEDSDGNLWIGTSGGGLYRYDPKTGKFTKFSED 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 121 RNMeRFKGLNDVIVARNGDIYF-TDQGqtgmtdqtglVYRLSPNGKLDTLLCNGISPNGLvlnPEETVLYVAMTRDNSVW 199
Cdd:COG3292 353 NGL-SNNFIRSILEDSDGNLWVgTNGG----------LYRLDPKTGKFTNFTHDPDKNGL---SSNYINSIFEDSDGRLW 418
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1218458574 200 ---------RLplhsDGTTTKAAKFFTSFGIagPD----GLTVDEEGNL 235
Cdd:COG3292 419 igtdggglyRY----DPKTGKFKHFTTKDGL--PSntiySILEDDNGNL 461
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
4-198 |
6.70e-04 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 40.45 E-value: 6.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 4 FYPPPRVVTARTFSSVPITLWSTKTTDWLPGSGAPPKIFLEGPATDTQGN-LFVVDVPYGRILRCELKSREWEVLADFDG 82
Cdd:COG3391 31 GGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDLATGKVVATIPVGG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 83 EANGLALNEEG-ELIVADYKNG-LMKCDPRTGKVdpillRRNMERFKGLNDVIVARNGD-IYFTDQGQTGMTDqtgLVYR 159
Cdd:COG3391 111 GPRGLAVDPDGgRLYVADSGNGrVSVIDTATGKV-----VATIPVGAGPHGIAVDPDGKrLYVANSGSNTVSV---IVSV 182
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1218458574 160 LSP-NGKLDTLLCNGISPNGLVLNPEETVLYVAMTRDNSV 198
Cdd:COG3391 183 IDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNTS 222
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
128-297 |
5.98e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 37.69 E-value: 5.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 128 GLNDVIVARNGDIYFTDQGqtgmtdqTGLVYRLSP-NGKLDTLLCNGIS-PNGLVLNPEETVlYVAMTRDNSVWRLplhs 205
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDQG-------GGRIGRLDPaTGEFTEYPLGGGSgPHGIAVDPDGNL-WFTDNGNNRIGRI---- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 206 DGTTTKAAKFFTSFGIAGPDGLTVDEEGNLfichpsllsifvvtkhgiplarivppgehgtsvtncifgstkedrnrlYF 285
Cdd:COG4257 86 DPKTGEITTFALPGGGSNPHGIAFDPDGNL------------------------------------------------WF 117
|
170
....*....|..
gi 1218458574 286 TDSTIGRICYVD 297
Cdd:COG4257 118 TDQGGNRIGRLD 129
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
125-237 |
7.86e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 37.51 E-value: 7.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1218458574 125 RFKGLNDVIVARNGDIYFTDQGQtgmtdqtGLVYRLSPNGKLDTLLCNGI--------------SPNGLVLNPEETvLYV 190
Cdd:cd14953 21 RFNSPSGVAVDAAGNLYVADRGN-------HRIRKITPDGVVTTVAGTGTagfadgggaaaqfnTPSGVAVDAAGN-LYV 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1218458574 191 AMTRDNSVWRL--------------PLHSDGTTTKAAKFFtsfgiaGPDGLTVDEEGNLFI 237
Cdd:cd14953 93 ADTGNHRIRKItpdgvvstlagtgtAGFSDDGGATAAQFN------YPTGVAVDAAGNLYV 147
|
|
| |
