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Conserved domains on  [gi|1229266197|gb|OYC99674|]
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AsnC family transcriptional regulator protein (plasmid) [Rhizobium sp. N4311]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-140 2.56e-50

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 157.63  E-value: 2.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197   1 MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHARIAPRRIAPVASVMMEVTLANHRqad 80
Cdd:COG1522     1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR--- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197  81 FERFERAVAAIPEIVACWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIV 140
Cdd:COG1522    78 LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFV 137
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-140 2.56e-50

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 157.63  E-value: 2.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197   1 MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHARIAPRRIAPVASVMMEVTLANHRqad 80
Cdd:COG1522     1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR--- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197  81 FERFERAVAAIPEIVACWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIV 140
Cdd:COG1522    78 LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFV 137
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-150 1.30e-36

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 123.72  E-value: 1.30e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197   3 LDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHARIAPRRIAPVASVMMEVTLANHRQADFE 82
Cdd:PRK11169   12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1229266197  83 RFERAVAAIPEIVACWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIVTKTVKEETVL 150
Cdd:PRK11169   92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRL 159
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-112 1.95e-31

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 108.76  E-value: 1.95e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197    3 LDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHARIAPRRIAPVASVMMEVTLanHRQADFE 82
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 1229266197   83 RFERAVAAIPEIVACWSVGGGVDYILKIIA 112
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 69-143 2.38e-19

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 76.80  E-value: 2.38e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1229266197  69 MEVTLANHRqaDFERFERAVAAIPEIVACWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIVTKT 143
Cdd:pfam01037   1 VEVKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-55 1.16e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.21  E-value: 1.16e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1229266197   4 DAIDLRILDAVqRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHAR 55
Cdd:cd00090     6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-140 2.56e-50

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 157.63  E-value: 2.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197   1 MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHARIAPRRIAPVASVMMEVTLANHRqad 80
Cdd:COG1522     1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR--- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197  81 FERFERAVAAIPEIVACWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIV 140
Cdd:COG1522    78 LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFV 137
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-150 1.30e-36

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 123.72  E-value: 1.30e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197   3 LDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHARIAPRRIAPVASVMMEVTLANHRQADFE 82
Cdd:PRK11169   12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1229266197  83 RFERAVAAIPEIVACWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIVTKTVKEETVL 150
Cdd:PRK11169   92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRL 159
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-112 1.95e-31

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 108.76  E-value: 1.95e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197    3 LDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHARIAPRRIAPVASVMMEVTLanHRQADFE 82
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 1229266197   83 RFERAVAAIPEIVACWSVGGGVDYILKIIA 112
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 69-143 2.38e-19

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 76.80  E-value: 2.38e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1229266197  69 MEVTLANHRqaDFERFERAVAAIPEIVACWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIVTKT 143
Cdd:pfam01037   1 VEVKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-49 1.32e-14

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 63.99  E-value: 1.32e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1229266197   6 IDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVI 49
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
4-44 1.77e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 60.85  E-value: 1.77e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1229266197   4 DAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLE 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-133 3.76e-10

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 55.10  E-value: 3.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229266197   1 MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHARIAPRRIAPVASVMMEVTLANHRqaD 80
Cdd:PRK11179    5 YQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK--D 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1229266197  81 FERFERAVAAIPEIVACWSVGGGVDYILKIIAPDIDAYQRLvdgLLDRELGID 133
Cdd:PRK11179   83 YPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHV---LINKIQTID 132
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-55 1.16e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.21  E-value: 1.16e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1229266197   4 DAIDLRILDAVqRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVITGYHAR 55
Cdd:cd00090     6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 1-50 1.37e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 38.36  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1229266197   1 MKLDAIDLRILDAV-QRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGVIT 50
Cdd:COG2512    11 PELLEDERRVLELLrENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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