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Conserved domains on  [gi|139492|sp|P03759|]
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RecName: Full=Protein rexB

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RexB super family cl24515
Membrane-anchored ion channel, Abi component; RexB is a family of anti-lambda phage ...
 6-144 3.11e-74

Membrane-anchored ion channel, Abi component; RexB is a family of anti-lambda phage inner-membrane ion-channels with four transmembrane domains. On infection by phage, a phage protein-DNA complex is produced as a replication or recombination intermediate which activates RexA. RexA is an intracellular sensor that activates the membrane-anchored RexB. At least two RexA proteins are needed to activate one RexB protein. Activation opens the ion-channel leading to a drop in membrane potential, the outcome of which is the death of the host cell but also the cessation or abortion of the phage infection. RexA-RexB is one of the most well characterized bacterial abortive infection systems, or Abis.


The actual alignment was detected with superfamily member pfam15968:

Pssm-ID: 292590  Cd Length: 139  Bit Score: 217.91  E-value: 3.11e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139492       6 MPGVYIVIIPYVIVSICYLLFRHYIPGVSFSAHRDGLGATLSSYAGTMIAILIAALTFLIGSRTRRLAKIREYGYMTSVV 85
Cdd:pfam15968   1 MPGVYIVIIPYVIVSICYLLFRHYIPGVSFSAHRDGLGATLSSYAGTMIAILIAALTFLIGSRTRRLAKIREYGYMTSVV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 139492      86 IVYALSFVELGALFFCGLLLLSSISGYMIPTIAIGIASASFIHICILVFQLYNLTREQE 144
Cdd:pfam15968  81 IVYALSFVELGALFFCGLLLLSSISGYMIPTIAIGIASASFIHICILVFQLYNLTREQE 139
 
Name Accession Description Interval E-value
RexB pfam15968
Membrane-anchored ion channel, Abi component; RexB is a family of anti-lambda phage ...
 6-144 3.11e-74

Membrane-anchored ion channel, Abi component; RexB is a family of anti-lambda phage inner-membrane ion-channels with four transmembrane domains. On infection by phage, a phage protein-DNA complex is produced as a replication or recombination intermediate which activates RexA. RexA is an intracellular sensor that activates the membrane-anchored RexB. At least two RexA proteins are needed to activate one RexB protein. Activation opens the ion-channel leading to a drop in membrane potential, the outcome of which is the death of the host cell but also the cessation or abortion of the phage infection. RexA-RexB is one of the most well characterized bacterial abortive infection systems, or Abis.


Pssm-ID: 292590  Cd Length: 139  Bit Score: 217.91  E-value: 3.11e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139492       6 MPGVYIVIIPYVIVSICYLLFRHYIPGVSFSAHRDGLGATLSSYAGTMIAILIAALTFLIGSRTRRLAKIREYGYMTSVV 85
Cdd:pfam15968   1 MPGVYIVIIPYVIVSICYLLFRHYIPGVSFSAHRDGLGATLSSYAGTMIAILIAALTFLIGSRTRRLAKIREYGYMTSVV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 139492      86 IVYALSFVELGALFFCGLLLLSSISGYMIPTIAIGIASASFIHICILVFQLYNLTREQE 144
Cdd:pfam15968  81 IVYALSFVELGALFFCGLLLLSSISGYMIPTIAIGIASASFIHICILVFQLYNLTREQE 139
 
Name Accession Description Interval E-value
RexB pfam15968
Membrane-anchored ion channel, Abi component; RexB is a family of anti-lambda phage ...
 6-144 3.11e-74

Membrane-anchored ion channel, Abi component; RexB is a family of anti-lambda phage inner-membrane ion-channels with four transmembrane domains. On infection by phage, a phage protein-DNA complex is produced as a replication or recombination intermediate which activates RexA. RexA is an intracellular sensor that activates the membrane-anchored RexB. At least two RexA proteins are needed to activate one RexB protein. Activation opens the ion-channel leading to a drop in membrane potential, the outcome of which is the death of the host cell but also the cessation or abortion of the phage infection. RexA-RexB is one of the most well characterized bacterial abortive infection systems, or Abis.


Pssm-ID: 292590  Cd Length: 139  Bit Score: 217.91  E-value: 3.11e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139492       6 MPGVYIVIIPYVIVSICYLLFRHYIPGVSFSAHRDGLGATLSSYAGTMIAILIAALTFLIGSRTRRLAKIREYGYMTSVV 85
Cdd:pfam15968   1 MPGVYIVIIPYVIVSICYLLFRHYIPGVSFSAHRDGLGATLSSYAGTMIAILIAALTFLIGSRTRRLAKIREYGYMTSVV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 139492      86 IVYALSFVELGALFFCGLLLLSSISGYMIPTIAIGIASASFIHICILVFQLYNLTREQE 144
Cdd:pfam15968  81 IVYALSFVELGALFFCGLLLLSSISGYMIPTIAIGIASASFIHICILVFQLYNLTREQE 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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