|
Name |
Accession |
Description |
Interval |
E-value |
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
21-893 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1308.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 21 KKLIAIGEKWKQKTTRGLPKQDTLNSGS--KYILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGL 98
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKpkYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 99 PAENAAIERSINPAIWTRDNIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMT 178
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 179 VLANEQVDAQGRSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLNQLKDWPSNVKQMQKNWIGESVGAELVFKVADPKfEN 258
Cdd:TIGR00396 161 VLANEQVDSDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIADHD-EK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 259 LIVFTTRPETLFAVQYVALALDHPIVQKYCEEMPDLKEFIQKSDQ--LPNDTKE----GFQLPNIKAVNPLTKEEVPIFA 332
Cdd:TIGR00396 240 ITVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVAAFIKKILNktVAERTKAtkekKGVDTGIKAIHPLTGEKIPIWV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 333 APYVVSSYGSApsAVMGCPGHDNRDFEFWQTNCPGEHIKTCIApffDDASKVTEQERQRIIDTVPftstdgvltkecGEH 412
Cdd:TIGR00396 320 ANYVLMEYGTG--AVMGVPAHDERDFEFAQKYGLPIKPVIDPA---EKDLSLTAAYTEDGVLVNS------------GEF 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 413 SGVLTVVARKSIMGMLNSEGLSKSVVRYKIRDWLISRQRYWGTPIPIIHCDNCGPVPVPESDLPVKLPELEGLDTKG-NP 491
Cdd:TIGR00396 383 NGLNSSEARNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGgSP 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 492 LSTIDEFVNVACPSCGSPAKRETDTMDTFIDSSWYYFRFLDPKNTSKPFDREIASKNMPVDIYIGGVEHAILHLLYSRFI 571
Cdd:TIGR00396 463 LSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFF 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 572 AKFLGSINAWSDpagiFEPFKKLVTQGMVQGktYVDPDSGKfLKPDELTFVNDSPdgntvIIKSNGKVPVVSYEKMSKSK 651
Cdd:TIGR00396 543 HKFLRDIGYVNT----KEPFKKLINQGMVLG--FYYPPNGK-VPADVLTERDEKG-----KDKAGGELVYVGYEKMSKSK 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 652 YNGADPNECILRHGPDATRAHILFQSPIADALNWDESKIVGIERWLQKVLHLTKNILSlekdlAISKDYKTPTDLNDAEV 731
Cdd:TIGR00396 611 GNGIDPQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITG-----ELDAASLTVTALEEAQK 685
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 732 KFHNDFQRFLKSITESFEVNLSLNTVISDYMKLTNILESALKKgevrnEMIVQNLQKLVTVIYPAVPSISEEAAEMINSQ 811
Cdd:TIGR00396 686 ELRRDVHKFLKKVTEDLEKRESFNTAISAMMELLNKLYKAKKE-----ALMLEYLKGFVTVLSPFAPHLAEELWEKLGSE 760
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 812 M-EWNQYRWPEVERTTESKFkKFQIVVNGRVKFmyTADKNFLKLGRDAVIETLMNL-PEGRMYLMNKKIKK-FVMKFNVI 888
Cdd:TIGR00396 761 PfIIDNAKWPVVDETALVED-KTLIVVQVNGKF--RAKITVPKDADEEQVEELAKQdPEVKKYLENKTIKKvIYVPGKLV 837
|
....*
gi 135144 889 SFLFH 893
Cdd:TIGR00396 838 NFVIK 842
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
49-882 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 941.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 49 KYILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTRDNIAKMKQQMQS 128
Cdd:COG0495 35 YYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGLPAENAAIKNGVHPAEWTYENIANMRRQLKR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 129 MLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVDaQGRSWRSGAIVEKKQLKQWFL 208
Cdd:COG0495 115 LGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQTVLANEQVI-DGRCWRCGAPVEKKELPQWFL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 209 GITKFAPKLKKHLNQLKDWPSNVKQMQKNWIGESVGAELVFKVADPKfENLIVFTTRPETLFAVQYVALALDHPIVQKYC 288
Cdd:COG0495 194 KITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGSD-EKITVFTTRPDTLFGATFMVLAPEHPLVKELA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 289 --EEMPDLKEFI----QKSD---QLPNDTKEGFQLpNIKAVNPLTKEEVPIFAAPYVVSSYGSApsAVMGCPGHDNRDFE 359
Cdd:COG0495 273 tpEQNAAVAAFIeeakKKSEierTSETKEKTGVFT-GLYAINPLTGEKIPIWIADYVLMDYGTG--AVMAVPAHDQRDFE 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 360 FWQT-NCPgehIKTCIAPffDDASKVTeqerqriIDTVPFTsTDGVLTkecgeHSGVLT----VVARKSIMGMLNSEGLS 434
Cdd:COG0495 350 FAKKyGLP---IKQVIAP--EDGDDPD-------ILEEAYT-GDGVLI-----NSGEFDgldsEEAKEAIIEWLEEKGLG 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 435 KSVVRYKIRDWLISRQRYWGTPIPIIHCDNCGPVPVPESDLPVKLPELEGLD-TKGNPLSTIDEFVNVACPSCGSPAKRE 513
Cdd:COG0495 412 KRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDpTGGSPLARAPEWVNVTCPKCGGPARRE 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 514 TDTMDTFIDSSWYYFRFLDPKNTSKPFDREIASKNMPVDIYIGGVEHAILHLLYSRFIAKFL---GSINawSDpagifEP 590
Cdd:COG0495 492 TDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLrdlGLVS--FD-----EP 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 591 FKKLVTQGMVQgktyvdpDSGKflkpdeltfvndspDGntviiksngkVPVVSYEKMSKSKYNGADPNECILRHGPDATR 670
Cdd:COG0495 565 FKRLLTQGMVL-------EVGK--------------DG----------VVIGGIEKMSKSKGNVVDPDEIIEKYGADTLR 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 671 AHILFQSPIADALNWDESKIVGIERWLQKVLHLTKNILSLEKDlaiskdykTPTDLNDAEVKFHNDFQRFLKSITESFEv 750
Cdd:COG0495 614 LFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEALKL--------DVADLSEADKELRRALHKTIKKVTEDIE- 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 751 NLSLNTVISDYMKLTNILESALKKGEVRNEMIVQNLQKLVTVIYPAVPSISEEAAEMI-NSQMEWNQyRWPEVErttESK 829
Cdd:COG0495 685 RLRFNTAIAALMELVNALYKAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLgHEGSVADA-PWPEAD---EAA 760
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*..
gi 135144 830 FKK--FQIVV--NGRVKFMYTADKNflkLGRDAVIETLMNLPEGRMYLMNKKIKKFV 882
Cdd:COG0495 761 LVEdeVTIVVqvNGKVRGKIEVPAD---ASKEELEAAALADEKVQKFLEGKTIRKVI 814
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
30-821 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 622.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 30 WKQKTTRGLPKQDTLNSGSKYILCQFPYPSGA-LHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERS 108
Cdd:PLN02563 93 WEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEQYAIETG 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 109 INPAIWTRDNIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVdAQ 188
Cdd:PLN02563 173 THPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEV-VD 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 189 GRSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLNQLkDWPSNVKQMQKNWIGESVGAELVFKVAD----PKFENLIVFTT 264
Cdd:PLN02563 252 GLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDL-DWPESIKEMQRNWIGRSEGAELDFSVLDgegkERDEKITVYTT 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 265 RPETLFAVQYVALALDHPIVQ--------KYCEEMPDLKEfiQKSDQlpndtkEGFQLPNIK--------AVNPLTKEEV 328
Cdd:PLN02563 331 RPDTLFGATYLVVAPEHPLLSslttaeqkEAVEEYVDAAS--RKSDL------ERTELQKEKtgvftgsyAINPATGEAI 402
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 329 PIFAAPYVVSSYGSApsAVMGCPGHDNRDFEFWQT-NCPgehIKTCIAPF---FDDASKVTEQERQRIIDTVPFTSTDGV 404
Cdd:PLN02563 403 PIWVADYVLGSYGTG--AIMAVPAHDTRDFEFAQKfDLP---IKWVVKPAdgnEDDAEKAYTGEGVIVNSSSSGLDINGL 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 405 LTKEcgehsgvltvvARKSIMGMLNSEGLSKSVVRYKIRDWLISRQRYWGTPIPIIHCDNCG-PVPVPESDLPVKLPELE 483
Cdd:PLN02563 478 SSKE-----------AAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELD 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 484 GL---DTKGNPLSTIDEFVNVACPSCGSPAKRETDTMDTFIDSSWYYFRFLDPKNTSKPFDREIASKNMPVDIYIGGVEH 560
Cdd:PLN02563 547 DFtptGTGEPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEH 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 561 AILHLLYSRFIAKFLGSINAWSDPagifEPFKKLVTQGM----VQGKTYVDPDsGKFLKPDELTFVNDSPD--------- 627
Cdd:PLN02563 627 AVLHLLYARFWHKVLYDIGVVSTK----EPFQCLVNQGMilgeVEYTAFKDSD-GEYVSADTADRLGELQQekipeekvi 701
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 628 --GNTVIIKSNGKVPVVSY-EKMSKSKYNGADPNECILRHGPDATRAHILFQSPIADALNWDESKIVGIERWLQKVLHLT 704
Cdd:PLN02563 702 ksGDSFVLKDDPSIRLIARaHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLV 781
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 705 knilslEKDLAISKDYKTPTDLNDAEVKFHN--DFQRFLKSITESFEvNLSLNTVISDYMKLTNileSALKKGEVRNEMI 782
Cdd:PLN02563 782 ------VGAPLPDGSFRDGTVVTDEEPSLEQlrLLHKCIAKVTEEIE-STRFNTAISAMMEFTN---AAYKWDKVPREAI 851
|
810 820 830
....*....|....*....|....*....|....*....
gi 135144 783 vqnlQKLVTVIYPAVPSISEEAAEMINSQMEWNQYRWPE 821
Cdd:PLN02563 852 ----EPFVLLLSPYAPHLAEELWFRLGHSNSLAYEPWPE 886
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
49-685 |
3.00e-113 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 349.24 E-value: 3.00e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 49 KYILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTRDNIAKMKQQMQS 128
Cdd:cd00812 2 FYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLKR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 129 MLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDpvdmtvlaneqvdaqgrswrsgaivekKQLKQWFL 208
Cdd:cd00812 82 MGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC---------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 209 GI--TKFAPKLKkhlnqlkdwpsnvkqmqknwigesvgaelvfkvadpkfenlivfttrpetlfavqyvalaldhpivqk 286
Cdd:cd00812 135 KYseTEWKEKLL-------------------------------------------------------------------- 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 287 yceempdlkEFIQKSDQLPNDTKegfqlpnikavnpltkeevpifaapyvvssygsapsavmgcpghdnRDFEFWqtncp 366
Cdd:cd00812 147 ---------KDLEKLDGWPEEVR----------------------------------------------AMQENW----- 166
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 367 gehiktciapffddaskvteqerqriIDtvpftstdgvltkecgehsgvltvvarksimgmlnseglsksvvrykirdwl 446
Cdd:cd00812 167 --------------------------IG---------------------------------------------------- 168
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 447 ISRQRYWGTPIPIihcdncgpvpvpesdlpvklpelegldtkgnplstidefvnvacpscgspakreTDTMDTFIDSSWY 526
Cdd:cd00812 169 CSRQRYWGTPIPW------------------------------------------------------TDTMESLSDSTWY 194
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 527 YFRFLDPKNTSKP------FDREIASKNMPVDIYIGGVEHAILHLLYSRFIAKFLGSINAWSDpagifEPFKKLVTQGMV 600
Cdd:cd00812 195 YARYTDAHNLEQPyegdleFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLVTD-----EPPKGLIVQGMV 269
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 601 QGKTyvdpdsgkflkpdeltfvndspdgntviiksngkvpvvsyEKMSKSKYNGADPNECILRHGPDATRAHILFQSPIA 680
Cdd:cd00812 270 LLEG----------------------------------------EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPD 309
|
....*
gi 135144 681 DALNW 685
Cdd:cd00812 310 ADFDW 314
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
56-868 |
2.81e-68 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 243.81 E-value: 2.81e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAEnAAIERSINPAI-----------------WTRDN 118
Cdd:TIGR00422 42 PNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIATQ-VKVEKKLGAEGktkhdlgreefrekiweWKEES 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 119 IAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQvdaqgrswrsgaiV 198
Cdd:TIGR00422 121 GGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIE-------------V 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 199 EKKQLKQwflgitkfapklkkHLNQLKdwpsnvkqmqknwigesvgaelvFKVADPKFENLIVFTTRPETLFAVqyVALA 278
Cdd:TIGR00422 188 EYKEVKG--------------KLYYIR-----------------------YPLANGSKDYLVVATTRPETMFGD--TAVA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 279 LdHPIVQKYceempdlKEFIQKsdqlpndtkegfqlpniKAVNPLTKEEVPIFAAPYVVSSYGSApsAVMGCPGHDNRDF 358
Cdd:TIGR00422 229 V-HPEDERY-------KHLIGK-----------------KVILPLTGRKIPIIADEYVDMEFGTG--AVKVTPAHDFNDY 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 359 EFWQtncpgEHiktciapffddaskvtEQERQRIIDtvpftsTDGVLTKECGEHSGVLTVVARKSIMGMLNSEGL----- 433
Cdd:TIGR00422 282 EWGK-----RH----------------NLEFINILD------EDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLlvkie 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 434 -----------SKSVV-------------------------------------RY-----KIRDWLISRQRYWGTPIPII 460
Cdd:TIGR00422 335 phthnvgtcwrSGTVVepllskqwfvkvekladkaleaaeegeikfvpkrmekRYlnwlrNIKDWCISRQLIWGHRIPVW 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 461 HCDNCGPVPVPESDLPVKLPELEGLDTkgnplstidEFvnvacpscgspaKRETDTMDTFIDSSWYYFRFLDPKNTSKPF 540
Cdd:TIGR00422 415 YCKECGEVYVAKEEPLPDDKTNTGPSV---------EL------------EQDTDVLDTWFSSSLWPFSTLGWPDETKDL 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 541 DREiasknMPVDIYIGGveHAILHLLYSRFI---AKFLGSInawsdpagifePFKKLVTQGMVQGKtyvdpdsgkflkpd 617
Cdd:TIGR00422 474 KKF-----YPTDLLVTG--YDIIFFWVARMIfrsLALTGQV-----------PFKEVYIHGLVRDE-------------- 521
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 618 eltfvndspDGntviiksngkvpvvsyEKMSKSKYNGADPNECILRHGPDATRAHILFQSPIADALNWDESKIVGIERWL 697
Cdd:TIGR00422 522 ---------QG----------------RKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFL 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 698 QKVLHLTKNIL-SLEKDLAISKDYKTptdLNDAEVKFHNDFQRFLKSITESFEvNLSLNTVIS------------DYMKL 764
Cdd:TIGR00422 577 NKLWNASRFVLmNLSDDLELSGGEEK---LSLADRWILSKLNRTIKEVRKALD-KYRFAEAAKalyefiwndfcdWYIEL 652
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 765 TNIL---ESALKKGEVRNEMiVQNLQKLVTVIYPAVPSISEEAAEMINS------QMEW----NQYRWPEVERTTE---- 827
Cdd:TIGR00422 653 VKYRlynGNEAEKKAARDTL-YYVLDKALRLLHPFMPFITEEIWQHFKEgadsimLQSYpvvdAEFVDEEAEKAFEllke 731
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|
gi 135144 828 -----SKFKK-FQIVVNGRVK--FMYTADKNFLKLGRDAV-IETLMNLPE 868
Cdd:TIGR00422 732 iivsiRNLKAeSNIPPNAPLKvlLIYTEAETAERLKLNAVdIKGAINFSE 781
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
56-749 |
5.43e-59 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 216.21 E-value: 5.43e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLP----AENaaiERSINPAI------------WTRDNI 119
Cdd:PRK13208 47 PTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNGLPterkVEK---YYGIRKDDisreefielcreLTDEDE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 120 AKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLAneQVDaqgrswrsgaiVE 199
Cdd:PRK13208 124 KKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIA--QAE-----------VE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 200 KKQlkqwflgitkfapkLKKHLNQLKdwpsnvkqmqknwigesvgaelvFKVADPkfENLIVFTTRPETLFAVqyVALAL 279
Cdd:PRK13208 191 YRE--------------REGKLNYIK-----------------------FPVEDG--EEIEIATTRPELLPAC--VAVVV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 280 dHPIVQKYceempdlKEFIQKsdqlpndtkegfqlpniKAVNPLTKEEVPIFAAPYVVSSYGSApsAVMGCPGHDNRDFE 359
Cdd:PRK13208 230 -HPDDERY-------KHLVGK-----------------TAIVPLFGVEVPILADPLVDPDFGTG--AVMICTFGDKTDVT 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 360 FWQtncpgEH-IKTCIapffddaskvteqerqrIIDtvpftsTDGVLTKECGEHSGVLTVVARKSIMGMLNSEGL---SK 435
Cdd:PRK13208 283 WWR-----ELnLPTRI-----------------IID------EDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLlgkQE 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 436 SVVR--------------------------------------------YKIR----------DWLISRQRYWGTPIPIIH 461
Cdd:PRK13208 335 PIKHnvkfcercdtpleilvtrqwfikvldlkeellergkeinwypehMRVRlenwieglnwDWCISRQRYFGTPIPVWY 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 462 CDNCG-PVPVPESDLPVklpelegldtkgNPlsTIDEFVNVACPSCGSPA-KRETDTMDTFIDSS--WYYfrfldpkNTS 537
Cdd:PRK13208 415 CKDCGhPILPDEEDLPV------------DP--TKDEPPGYKCPQCGSPGfEGETDVMDTWATSSitPLI-------VTG 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 538 KPFDREIASKNMPVDIYIGGveHAILH--LLYSRFIAKFL-GSInawsdpagifePFKKLVTQGMVQGktyvdpdsgkfl 614
Cdd:PRK13208 474 WERDEDLFEKVFPMDLRPQG--HDIIRtwLFYTILRAYLLtGKL-----------PWKNIMISGMVLD------------ 528
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 615 kpdeltfvndsPDGntviiksngkvpvvsyEKMSKSKYNGADPNECILRHGPDATRAHILFQSPIADALnWDESKIVGIE 694
Cdd:PRK13208 529 -----------PDG----------------KKMSKSKGNVVTPEELLEKYGADAVRYWAASARLGSDTP-FDEKQVKIGR 580
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*.
gi 135144 695 RWLQKVLHLTKNILSLEKDLAISKDYKT-PTDLndaevKFHNDFQRFLKSITESFE 749
Cdd:PRK13208 581 RLLTKLWNASRFVLHFSADPEPDKAEVLePLDR-----WILAKLAKVVEKATEALE 631
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
236-447 |
2.34e-46 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 163.87 E-value: 2.34e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 236 KNWIGESVGAELVFKVADPKfENLIVFTTRPETLFAVQYVALALDHPIVQKYCEEMPDLKEFIQKSDQ-------LPNDT 308
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTD-EKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAFIEECKNtseiertSETKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 309 KEGFqLPNIKAVNPLTKEEVPIFAAPYVVSSYGSApsAVMGCPGHDNRDFEFWQTNcpGEHIKTCIAPFFDDASKVTEQE 388
Cdd:pfam13603 80 KEGV-FTGLYAIHPITGEKIPIWIANFVLMEYGTG--AVMAVPAHDQRDFEFAKKY--NLPIKPVIQPEDGDLDLDIMTE 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 135144 389 rqriidtvPFTsTDGVLTkecgeHSGVLTvvarksimGMLNSEGlsksvvRYKIRDWLI 447
Cdd:pfam13603 155 --------AYT-EEGILV-----NSGEFD--------GLDSEEA------KEAIIKKLE 185
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
56-686 |
2.81e-44 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 169.90 E-value: 2.81e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAEnAAIERSInpAIWTRDNIAKM------------- 122
Cdd:pfam00133 32 PNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTE-QVVEKKL--GIKEKKTRHKYgreefrekcrewk 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 123 -------KQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQV---DAQGRSW 192
Cdd:pfam00133 109 meyadeiRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVeykDVKGPSI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 193 rsgaivekkqlkqwflgitkfapklkkhlnqlkdwpsnvkqmqknwigesvgaELVFKVADPKFENLIVFTTRPETLFAV 272
Cdd:pfam00133 189 -----------------------------------------------------HVAFPLADDEGASLVIWTTTPWTLPGN 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 273 QYVALA--LDHPIVQKYCEEMPDLKEFIQKSDQLPNDTKE--GFQLPNIKAVNPLTKEEVPIFAAPYVVSSYGSApsAVM 348
Cdd:pfam00133 216 TAVAVNpeFDYVITGEGYILAEALLKSLYKKGTDKKILEDfrGKELEGKEAIHPFVNREIPIITDDYVDMEFGTG--AVH 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 349 GCPGHDNRDFEfwqtncpgehiktciapffddASKVTEQERQRIIDtvpftsTDGVLTKECGEHSGVLTVVARKSIMGML 428
Cdd:pfam00133 294 IAPAHGENDYE---------------------VGQRHNLEVINPVD------DDGTFTEEAPDFQGVYRFDARKKIVELL 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 429 NSEGL----------------SKSVVRYK----------------------------------------IRDWLISRQRY 452
Cdd:pfam00133 347 TEKGLllkiepfthsypfcwrSGTPIIPRatpqwfvrmdeladqaleavekvqfvpksgekryfnwlanIQDWCISRQRW 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 453 WGTPIPIIHCDNCGPV-PVPESDLPVKLPELEGLDTKGNPLSTIDEFVNVAcpscgSPAKRETDTMDTFIDS-SWYYFRF 530
Cdd:pfam00133 427 WGHPIPAWVSKDTEEVvCRGELFELVAGRFEEEGSIKWLHREAKDKLGYGK-----GTLEQDEDVLDTWFSSgSWPFSTL 501
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 531 LDPKNTSKPFdreiaSKNMPVDIYIGGVEhaILHLLYSRFI---AKFLGSinawsdpagifEPFKKLVTQGmvqgktyvd 607
Cdd:pfam00133 502 GWPFVNTEEF-----KKFFPADMLLEGSD--QTRGWFYRMImlsTALTGS-----------VPFKNVLVHG--------- 554
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 135144 608 pdsgkflkpdeltFVNDSpDGntviiksngkvpvvsyEKMSKSKYNGADPNECILRHGPDATRAHILFQSPIADaLNWD 686
Cdd:pfam00133 555 -------------LVRDE-QG----------------RKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRD-INLS 602
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
56-670 |
9.67e-40 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 151.63 E-value: 9.67e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAEN-----AAIERSINPAI-----------WTRDNI 119
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvvekkLGIEGKTRHDLgreeflekcweWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 120 AKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVdaqgrSWRSGAIVE 199
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV-----CSRSGDVIE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 200 KKQLKQWFLgitKFAPKLKKHLnqlkdwpSNVKQMQKNWIgesvgaelvfkvadpkfenlivfttrpetlfavqyvalal 279
Cdd:cd00817 165 PLLKPQWFV---KVKDLAKKAL-------EAVKEGDIKFV---------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 280 dhpivqkyceempdlkefiqksdqlpndtkegfqlpnikavnpltkeevpifaapyvvssygsapsavmgcPGHDNRDFE 359
Cdd:cd00817 195 -----------------------------------------------------------------------PERMEKRYE 203
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 360 FWQTNcpgehiktciapffddaskvteqerqriidtvpftstdgvltkecgehsgvltvvarksimgmlnseglsksvvr 439
Cdd:cd00817 204 NWLEN--------------------------------------------------------------------------- 208
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 440 ykIRDWLISRQRYWGTPIPIIHCDNCGPVPVPESDLPVklpelegldtkgnplstIDEFVNVACPSCGSPA-KRETDTMD 518
Cdd:cd00817 209 --IRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEA-----------------IDKAAPEACVPCGGEElKQDEDVLD 269
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 519 TFIDSS-WYYFRFLDPKNTsKPFDreiasKNMPVDIYIGGveHAILHLLYSRFIA---KFLGSInawsdpagifePFKKL 594
Cdd:cd00817 270 TWFSSSlWPFSTLGWPEET-KDLK-----KFYPTSLLVTG--HDIIFFWVARMIMrglKLTGKL-----------PFKEV 330
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 135144 595 VTQGMVQGktyvdpdsgkflkpdeltfvndsPDGntviiksngkvpvvsyEKMSKSKYNGADPNECILRHGPDATR 670
Cdd:cd00817 331 YLHGLVRD-----------------------EDG----------------RKMSKSLGNVIDPLDVIDGYGADALR 367
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
50-241 |
5.71e-33 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 129.96 E-value: 5.71e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 50 YILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTrDNIAKMKQQMQSM 129
Cdd:cd00814 3 LITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELC-DKYHEIFKDLFKW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 130 LaNFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLAneqvdaqgrswrsgaivEKKQLKQWFLG 209
Cdd:cd00814 82 L-NISFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP-----------------EWREEEHYFFR 143
|
170 180 190
....*....|....*....|....*....|....
gi 135144 210 ITKFAPKLKKHL--NQLKDWPSNVKQMQKNWIGE 241
Cdd:cd00814 144 LSKFQDRLLEWLekNPDFIWPENARNEVLSWLKE 177
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
50-239 |
7.24e-32 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 131.39 E-value: 7.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 50 YILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWtrdnIAKMKQQMQSM 129
Cdd:COG0143 4 LVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQEL----VDRIHAEFKEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 130 LANFD--WDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQV----------DAQG-------- 189
Cdd:COG0143 80 FEKLGisFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPDRYVegtcpkcgaeDAYGdqcencga 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 190 ----------RSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLNQLKDWPSNVKQMQKNWI 239
Cdd:COG0143 160 tleptelinpRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVRNEVLSWL 219
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
50-241 |
1.31e-31 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 127.79 E-value: 1.31e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 50 YILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPaiwtRDNIAKMKQQMQSM 129
Cdd:pfam09334 2 LVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITP----EELVDRYHEIHRED 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 130 LANFD--WDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQV----------DAQG-------- 189
Cdd:pfam09334 78 FKKFNisFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVegtcphcgseDARGdqcencgr 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 135144 190 ----------RSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLNQ-LKDWPSNVKQMQKNWIGE 241
Cdd:pfam09334 158 hleptelinpKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEEnNPEWPENVKNMVLEWLKE 220
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
50-239 |
1.13e-28 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 117.52 E-value: 1.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 50 YILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAA-----IERSINPAIWTRD------- 117
Cdd:cd00668 3 YVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggRKKKTIWIEEFREdpkefve 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 118 -NIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEaeinwdpvdmtvlaneqvdaqgrswRSGA 196
Cdd:cd00668 83 eMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGT-------------------------HPVR 137
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 135144 197 IVEkkqlkQWFLGITKFAPKLKKHLNQLKDWPSNVKQMQKNWI 239
Cdd:cd00668 138 ITE-----QWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWL 175
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
56-753 |
4.49e-28 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 121.71 E-value: 4.49e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIER-------SINPAIWT------RD----N 118
Cdd:TIGR00392 45 PYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTHGLPIEHKVEKKlgisgkkEISSLEIEefrekcREfalkQ 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 119 IAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVDAQGRSW--RSGA 196
Cdd:TIGR00392 125 IEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENYKdvKDPS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 197 IVEKKQLKQwflgitKFAPKLKKHLNQLKDW-------PSNVkqmqknwiGESVGAELVFKVA--DPKFENLIVFTTRPE 267
Cdd:TIGR00392 205 IYVKFPVKK------DKKTYLKVKLSSLLIWtttpwtlPSNL--------AIAVHPDFEYALVqdNTKVEYFILAKKLVE 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 268 TLFAvqyvALALDHPIVQKYceempdlkefiqksdqlpndtkEGFQLPNIKAVNPL------TKEEVP-IFAAPYVVSSY 340
Cdd:TIGR00392 271 KLYN----KAGSDYEIIKTF----------------------KGSDLEGLEYEHPLydfvsqLKEGAPvVIGGDHVTTED 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 341 GSApsAVMGCPGHDNRDFEFWQTN-----CP---------------GEHIKTCIAPFFDDASKVTEQERQ---------- 390
Cdd:TIGR00392 325 GTG--IVHTAPGHGEEDYEIGKKYglevlSPvdekgvytegvndfqGRFVKDADKDIIKANKIIIEQLKDkglllkaeki 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 391 --------RIIDTVPFTSTDG--VLTKECGEhsgvltvVARKSIMGM--LNSEGLSksvvRYK-----IRDWLISRQRYW 453
Cdd:TIGR00392 403 thsyphcwRTKTPVIYRATEQwfIKTKDIKD-------QMLEQIKKVnwVPEWGEG----RFGnwlenRPDWCISRQRYW 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 454 GTPIPIIHCDNCGPVPVPES-DLPVKLPELEGLDTKGNPLST--IDEfVNVACPSCGsPAKRETDTMDTFIDSSWYYFRF 530
Cdd:TIGR00392 472 GIPIPIWYCEDTGEPIVVGSiEELIELIELKGIDAWFEDLHRdfLDK-ITLKSGDGG-EYRRVPDVLDVWFDSGSMPYAS 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 531 LDPKNTSKPFDreiasKNMPVDIYIGGVEHailhllySR--FIAKFLGSInAWSDPAgifePFKKLVTQGmvqgktyvdp 608
Cdd:TIGR00392 550 IHYPFENEKFK-----EVFPADFILEGSDQ-------TRgwFYSSLAIGT-ALFGQA----PYKNVITHG---------- 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 609 dsgkflkpdeltFVNDSpDGNtviiksngkvpvvsyeKMSKSKYNGADPNECILRHGPDATRAHILFQSPIAD-ALNWDE 687
Cdd:TIGR00392 603 ------------FTLDE-KGR----------------KMSKSLGNVVDPLKVINKYGADILRLYVASSDPWEDlRFSDEI 653
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 688 SKIVG----IERW-LQKVLHLTKNI--------------LSLEKDLAISKDYKTPTDLNDAEVKFhnDFQRFLKSITESF 748
Cdd:TIGR00392 654 LKQVVekyrKIRWnTYRFLLTYANLdkfdplfnsvavekFPEEDRWILSRLNSLVEEVNEALEKY--NFHKVLRALQDFI 731
|
....*
gi 135144 749 EVNLS 753
Cdd:TIGR00392 732 VEELS 736
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
56-681 |
4.27e-23 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 105.93 E-value: 4.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAA-----IERSINPAI-----------WTRDNI 119
Cdd:COG0060 55 PYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDCHGLPIELKVekelgIKKKDIEKVgiaefrekcreYALKYV 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 120 AKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQV---DAQGRSwrsga 196
Cdd:COG0060 135 DEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVeykDVTSPS----- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 197 ivekkqlkqwflgIT-KFAPKLKKHLNQLKD-----W-------PSNVkqmqknwiGESVGaelvfkvadPKFENLIVFT 263
Cdd:COG0060 210 -------------IYvKFPVKDEKALLLLEDaylviWtttpwtlPANL--------AVAVH---------PDIDYVLVEV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 264 TRPETLfavqYVALALdhpiVQKYCEEMpDLKEF-IQKsdqlpndTKEGFQLPNIKAVNPL-----TKEEVPIFAAPYVV 337
Cdd:COG0060 260 TGGERL----ILAEAL----VEAVLKEL-GIEDYeVLA-------TFKGAELEGLRYEHPFyyvvgYDRAHPVILGDYVT 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 338 SSYGSapsavmGC----PGH--DnrDFEFWQTN-----CP---------------GEHIKtciapffdDASK-VTE--QE 388
Cdd:COG0060 324 TEDGT------GIvhtaPGHgeD--DFEVGKKYglpvlNPvdddgrfteeaplfaGLFVK--------DANPaIIEdlKE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 389 RQRII---------------DT------VP--FTSTDGVLTK------------ECGEhsgvltvvARksIMGMLnsEGL 433
Cdd:COG0060 388 RGALLarekithsyphcwrcKTpliyraTPqwFISMDKLRDRaleaiekvnwipEWGE--------GR--FGNML--ENR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 434 sksvvrykiRDWLISRQRYWGTPIPIIHCDNCGpvpvpESDLPVKLPE--LEGLDTKG-NPLSTID---EFV--NVACPS 505
Cdd:COG0060 456 ---------PDWCISRQRYWGVPIPIWVCEDCG-----ELHRTEEVIGsvAELLEEEGaDAWFELDlhrPFLdeTLKCPK 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 506 CGSPAKRETDTMDTFIDSSwyyfrfldpkntSKPF----DREiaSKNMPVDIYiggVEhAI---------LHLLysrfia 572
Cdd:COG0060 522 CGGTMRRVPDVLDVWFDSG------------SMHFavleNRE--ELHFPADFY---LE-GSdqtrgwfysSLLT------ 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 573 kflgSInawsdpaGIFE--PFKKLVTQGmvqgktyvdpdsgkflkpdeltFVNDSpDGNtviiksngkvpvvsyeKMSKS 650
Cdd:COG0060 578 ----ST-------ALFGraPYKNVLTHG----------------------FVLDE-DGR----------------KMSKS 607
|
730 740 750
....*....|....*....|....*....|.
gi 135144 651 KYNGADPNECILRHGPDATRAHILFQSPIAD 681
Cdd:COG0060 608 LGNVVDPQEVIDKYGADILRLWVASSDYWGD 638
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
56-670 |
2.45e-22 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 103.53 E-value: 2.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLpAENAAIERSINPA------------------IWTRD 117
Cdd:PRK14900 57 PNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGI-ATQMIVEKELKKTekksrhdlgreaflervwAWKEQ 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 118 NIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVDAQgrswrsgai 197
Cdd:PRK14900 136 YGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHE--------- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 198 vEKKQLKQWflgitkfapklkkhlnqlkdwpsnvkqmqknwigesvgaELVFKVADPKFEnLIVFTTRPETLFAVQYVAL 277
Cdd:PRK14900 207 -EAHQGELW---------------------------------------SFAYPLADGSGE-IVVATTRPETMLGDTAVAV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 278 aldHPIVQKYceempdlKEFIQKsdqlpndtkegfqlpniKAVNPLTKEEVPIFA-APYVVSSYGSApsAVMGCPGHDNR 356
Cdd:PRK14900 246 ---HPLDPRY-------MALHGK-----------------KVRHPITGRTFPIVAdAILVDPKFGTG--AVKVTPAHDFN 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 357 DFEFWQTNcpGEHIKTCIAPffddaskvteqerqriidtvpftstDGVLTKECGEHSGVLTVVARKSIMGMLNSEGL--- 433
Cdd:PRK14900 297 DFEVGKRH--GLEMITVIGP-------------------------DGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLdrg 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 434 -------------SKSVV----------------------------RY--------------KIRDWLISRQRYWGTPIP 458
Cdd:PRK14900 350 akphvlplgrcqrSATILepllsdqwyvrieplarpaieaveqgrtRFipeqwtntymawmrNIHDWCISRQLWWGHQIP 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 459 IIHCDNCGPVPVPESdlpvklPElegldtkgnplstidefvnvACPSCGSPAKRE-TDTMDTFIDSSWYYFRFLD-PKNT 536
Cdd:PRK14900 430 AWYCPDGHVTVARET------PE--------------------ACSTCGKAELRQdEDVLDTWFSSGLWPFSTMGwPEQT 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 537 S--KPFdreiasknMPVDIYIGGveHAILHLLYSRFIA---KFLGSInawsdpagifePFKKLVTQGMVQgktyvdpdsg 611
Cdd:PRK14900 484 DtlRTF--------YPTSVMETG--HDIIFFWVARMMMmglHFMGEV-----------PFRTVYLHPMVR---------- 532
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*....
gi 135144 612 kflkpDEltfvndspdgntviiksngkvpvvSYEKMSKSKYNGADPNECILRHGPDATR 670
Cdd:PRK14900 533 -----DE------------------------KGQKMSKTKGNVIDPLVITEQYGADALR 562
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
56-227 |
7.19e-22 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 100.34 E-value: 7.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTRDNIAKMKQQMQSMlaNFDW 135
Cdd:PRK11893 10 YYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEAL--NISY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 136 DREITTCDPEYYKFTQWIFLKLFENGLAYRKEA--------EINWDPvdmtvlaNEQVDAQGRSWRSGAIVEKKQLKQWF 207
Cdd:PRK11893 88 DDFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYegwycvrcEEFYTE-------SELIEDGYRCPPTGAPVEWVEEESYF 160
|
170 180
....*....|....*....|
gi 135144 208 LGITKFAPKLKKHLNQLKDW 227
Cdd:PRK11893 161 FRLSKYQDKLLELYEANPDF 180
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
62-358 |
3.30e-21 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 99.56 E-value: 3.30e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 62 LHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLP----AENAA--------------------IERSINPAIWTRD 117
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERIArgdpetielykslygipeeeLEKFKDPEYIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 118 NIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLAN----EQVDAQgrswr 193
Cdd:PRK12300 81 FSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDhdllDGEEPE----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 194 sgaIVEkkqlkqwFLGItKFAPklkkhlnqlkdwpsnvkqmqknwiGESVgaelvfkvadpkfeNLIVFTTRPETLFAV- 272
Cdd:PRK12300 156 ---IVE-------YTLI-KFEE------------------------SEDL--------------ILPAATLRPETIFGVt 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 273 --------QYVALALD--HPIVQKYCEEmpDLKEfiQKSDQLPNDTKEGFQLPNIKAVNPLTKEEVPIFAAPYVVSSYGS 342
Cdd:PRK12300 187 nlwvnpdaTYVKAEVDgeKWIVSKEAAE--KLSF--QDRDVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGT 262
|
330
....*....|....*.
gi 135144 343 ApsAVMGCPGHDNRDF 358
Cdd:PRK12300 263 G--VVMSVPAHAPYDY 276
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
53-239 |
4.18e-21 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 98.69 E-value: 4.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 53 CQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPaiwtRDNIAKMKQQMQSMLAN 132
Cdd:PRK00133 8 CALPYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITP----EELIARYHAEHKRDFAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 133 FD--WDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQV----------DAQG----------- 189
Cdd:PRK00133 84 FGisFDNYGSTHSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLPDRFVkgtcpkcgaeDQYGdncevcgatys 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 135144 190 -------RSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLNQLKDWPSNVKQMQKNWI 239
Cdd:PRK00133 164 ptelinpKSAISGATPVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL 220
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
60-474 |
2.69e-19 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 93.63 E-value: 2.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 60 GALHIGHLRVYVISDSLNRFYKQKGYNV----------I-----------------HPMGWDAFglpaenaaIERsinpa 112
Cdd:PRK05729 49 GSLHMGHALNNTLQDILIRYKRMQGYNTlwlpgtdhagIatqmvverqlaaegksrHDLGREKF--------LEK----- 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 113 IW-----TRDNIakmKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVDA 187
Cdd:PRK05729 116 VWewkeeSGGTI---TNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEY 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 188 QgrswrsgaivEKKQlkqwflgitkfapklkkHLNQLKdwpsnvkqmqknwigesvgaelvFKVADPKfENLIVFTTRPE 267
Cdd:PRK05729 193 K----------EVKG-----------------KLWHIR-----------------------YPLADGS-DYLVVATTRPE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 268 TLFAVQYVALaldHPIVQKYceempdlKEFIQKsdqlpndtkegfqlpniKAVNPLTKEEVPIFAAPYVVSSYGSapsav 347
Cdd:PRK05729 222 TMLGDTAVAV---NPEDERY-------KHLIGK-----------------TVILPLVGREIPIIADEYVDPEFGT----- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 348 mGC----PGHDNRDFEfwqtncpgehiktcIApffddaskvteqerQR-------IIDtvpftsTDGVLTKECGEHSGVL 416
Cdd:PRK05729 270 -GAvkitPAHDPNDFE--------------VG--------------KRhnlpminIMD------EDGTINENPGEYQGLD 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 417 TVVARKSIMGMLNSEGL----------------SKSVV---------------------------------RYK------ 441
Cdd:PRK05729 315 RFEARKAIVADLEELGLlvkiephthsvghsdrSGVVIepylsdqwfvkmkplakpaleavengeikfvpeRWEktyfhw 394
|
490 500 510
....*....|....*....|....*....|....*.
gi 135144 442 ---IRDWLISRQRYWGTPIPIIHCDNcGPVPVPESD 474
Cdd:PRK05729 395 menIQDWCISRQLWWGHRIPAWYDED-GEVYVGREE 429
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
60-525 |
1.21e-18 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 91.27 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 60 GALHIGHLRVYVISDSLNRFYKQKGYNV----------I-----------------HPMGWDAFglpaenaaIERsinpa 112
Cdd:COG0525 48 GSLHMGHALNNTLQDILIRYKRMQGYNTlwqpgtdhagIatqavverqlaeegksrHDLGREKF--------LER----- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 113 IW-----TRDNIakmKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLAN---EQ 184
Cdd:COG0525 115 VWewkeeSGGTI---TNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDlevEH 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 185 VDAQGRSWrsgaivekkqlkqwflgitkfapklkkHLNqlkdwpsnvkqmqknwigesvgaelvFKVADPKfENLIVFTT 264
Cdd:COG0525 192 EEVKGHLW---------------------------HIR--------------------------YPLADGS-GYIVVATT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 265 RPETLFAVQYVALaldHPIVQKYceempdlKEFIQKsdqlpndtkegfqlpniKAVNPLTKEEVPIFAAPYVVSSYGSap 344
Cdd:COG0525 218 RPETMLGDTAVAV---HPEDERY-------KHLIGK-----------------TVILPLVGREIPIIADEYVDPEFGT-- 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 345 savmGC----PGHDNRDFEFWQTncpgeH----IktciapffddaskvteqerqRIIDtvpftsTDGVLTKECGEHSGVL 416
Cdd:COG0525 269 ----GAvkitPAHDPNDFEVGKR-----HnlpmI--------------------NILD------EDGTINENAGKYRGLD 313
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 417 TVVARKSIMGMLNSEGL----------------SKSVV---------------------------------RYK------ 441
Cdd:COG0525 314 RFEARKAIVADLEELGLlvkvephkhsvghsdrSGTVIepylsdqwfvkmkplakpaieavedgeikfvpeRWEktyfhw 393
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 442 ---IRDWLISRQRYWGTPIPIIHCDNcGPVPVPESDlpvklPElegldtkgnplstidefvnvACPSCGSPA-KRETDTM 517
Cdd:COG0525 394 menIRDWCISRQLWWGHRIPAWYCPD-GEVYVARTE-----PE--------------------ACAKAGSVNlTQDEDVL 447
|
....*....
gi 135144 518 DT-FidSSW 525
Cdd:COG0525 448 DTwF--SSA 454
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
56-241 |
1.70e-18 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 87.67 E-value: 1.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAEnAAIERSINpaIWTRDNIAKM------------- 122
Cdd:cd00818 10 PYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIE-LKVEKELG--ISGKKDIEKMgiaefnakcrefa 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 123 KQQMQSMLANF-------DWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWdPVdmtvlaneqvdaqgrswrsg 195
Cdd:cd00818 87 LRYVDEQEEQFqrlgvwvDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-PL-------------------- 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 135144 196 aIVekKQLKQWFLGITKFAPKLKKHLNQLKDWPSNVKQMQKNWIGE 241
Cdd:cd00818 146 -IY--RATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNWLEN 188
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
29-472 |
5.42e-18 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 89.29 E-value: 5.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 29 KWKQKTTRGLPKQD--TLNSGSKYILCqFPYP--SGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLpAENAA 104
Cdd:PTZ00419 39 EWWEKSGFFKPAEDakSLNSGKKFVIV-LPPPnvTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGI-ATQVV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 105 IERSI----NPA--------------IWTRDNIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRK 166
Cdd:PTZ00419 117 VEKKLmkeeNKTrhdlgreeflkkvwEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 167 EAEINWDPVDMTVLANEQVDaqgrswrsgaivekkqlkqwFLGITKFApKLKKhlnqlkdwPSNVKQMQKNWIgesvgAE 246
Cdd:PTZ00419 197 TRLVNWCCYLKTAISDIEVE--------------------FEEIEKPT-KITI--------PGYDKKVEVGVL-----WH 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 247 LVFKVADPKFENLIVFTTRPETLFAvqYVALALdHPIVQKYceempdlKEFIQKsdqlpndtkegfqlpniKAVNPLTK- 325
Cdd:PTZ00419 243 FAYPLEDSGQEEIVVATTRIETMLG--DVAVAV-HPKDERY-------KKLHGK-----------------ELIHPFIPd 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 326 EEVPIFAAP-YVVSSYGSApsAVMGCPGHDNRDFEfwqtnCPGEHIKTCIApFFDDaskvteqerqriidtvpftstDGV 404
Cdd:PTZ00419 296 RKIPIIADDeLVDMEFGTG--AVKITPAHDPNDYE-----IAKRHNLPFIN-IFTL---------------------DGK 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 405 LTKECGEHSGVLTVVARKSIMGMLNSEGLSKSVVRYK------------------------------------------- 441
Cdd:PTZ00419 347 INENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPmrlprcsrsgdivepmlipqwyvnckdmakraveavrngelki 426
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 135144 442 ---------------IRDWLISRQRYWGTPIPIIHCdnCGPVPVPE 472
Cdd:PTZ00419 427 ipsshenvwyhwlenIQDWCISRQLWWGHRIPAYRV--ISKGPETD 470
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
25-711 |
6.60e-13 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 72.84 E-value: 6.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 25 AIGEKWKQ--------KTTRGLPKqdtlnsgskYIlcqF----PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMG 92
Cdd:PLN02882 16 KILSLWSEidafktqlKRTEGLPE---------YI---FydgpPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 93 WDAFGLPAENaAIERSINpaIWTRDNIAKM-----KQQMQSMLANF--DWDREIT-------------TCDPEYYKFTQW 152
Cdd:PLN02882 84 WDCHGLPVEY-EIDKKLG--IKRRDDVLKMgidkyNEECRSIVTRYskEWEKTVTrtgrwidfendykTMDPKFMESVWW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 153 IFLKLFENGLAYRKEAEINWDPVDMTVLANEQVDAQGRSWRSGAIV---------EKKQLKQWF---------------- 207
Cdd:PLN02882 161 VFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMvsfpivgdpDNASFVAWTttpwtlpsnlalcvnp 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 208 -LGITKFAPKLKKH--------LNQLkdwPSNVKQMQKNWIGESV-----------GAELVFKVADPKFEnliVFTTRPE 267
Cdd:PLN02882 241 nFTYVKVRNKYTGKvyivaesrLSAL---PTAKPKSKKGSKPENAaegyevlakvpGSSLVGKKYEPLFD---YFSEFSD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 268 TLFAV---QYVALALDHPIVQK---YCEEmpDLK-----EFIQKSDQLPNdtkegfqlpnikAV--NPLTKEEVPIFAAP 334
Cdd:PLN02882 315 TAFRVvadDYVTDDSGTGVVHCapaFGED--DYRvclanGIIEKGGNLPV------------PVddDGCFTEKVTDFSGR 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 335 YVVSSYGSAPSAVMGC-----PGHDNRDFEF-WQTNCPgeHIKTCIAPFFddaSKVtEQERQRIIdtvpftstdgvltkE 408
Cdd:PLN02882 381 YVKDADKDIIAAIKAKgrlvkSGSITHSYPFcWRSDTP--LIYRAVPSWF---VKV-EEIKDRLL--------------E 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 409 CGEHS-GVLTVVARKSIMGMLNSEglsksvvrykiRDWLISRQRYWGTPIPIIHCDNCGPVPVPESdlPVKLPELEGLDT 487
Cdd:PLN02882 441 NNKQTyWVPDYVKEKRFHNWLENA-----------RDWAVSRSRFWGTPLPIWISDDGEEVVVIGS--IAELEKLSGVKV 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 488 KGNPLSTIDEfvnVACPSCGSPA----KRETDTMDTFIDSS---WYYFRFldpkntskPFD-REIASKNMPVDiyiggve 559
Cdd:PLN02882 508 TDLHRHFIDH---ITIPSSRGPEfgvlRRVDDVFDCWFESGsmpYAYIHY--------PFEnKELFEKNFPAD------- 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 560 hailhllysrFIAKFLGSINAW------------SDPAgifepFKKLVTQGMVqgktyvdpdsgkflkpdeltfvndspd 627
Cdd:PLN02882 570 ----------FVAEGLDQTRGWfytlmvlstalfDKPA-----FKNLICNGLV--------------------------- 607
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 628 gntviIKSNGKvpvvsyeKMSKSKYNGADPNECILRHGPDATRAHiLFQSPI--ADALNWDESKIVGIER-----WLQKV 700
Cdd:PLN02882 608 -----LAEDGK-------KMSKSLKNYPDPNEVIDKYGADALRLY-LINSPVvrAEPLRFKEEGVFGVVKdvflpWYNAY 674
|
810
....*....|.
gi 135144 701 LHLTKNILSLE 711
Cdd:PLN02882 675 RFLVQNAKRLE 685
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
45-181 |
1.02e-12 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 72.11 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 45 NSGSKYILCQFP-YPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAE-------NAAIERSINPaIWTR 116
Cdd:PLN02843 29 NNGESFTLHDGPpYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIElkvlqslDQEARKELTP-IKLR 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 135144 117 DNIAK-----MKQQMQSmlanF-------DWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLA 181
Cdd:PLN02843 108 AKAAKfakktVDTQRES----FkrygvwgDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTALA 180
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
57-223 |
3.95e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 69.83 E-value: 3.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 57 YPSGALHIGHlrVY--VISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTrDNIAKMKQQMQSMLaNFD 134
Cdd:PRK12267 14 YPNGKPHIGH--AYttIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYV-DEISAGFKELWKKL-DIS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 135 WDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEiNWDPV-DMTVLANEQVDAQGRSWRSGAIVEKKQLKQWFLGITKF 213
Cdd:PRK12267 90 YDKFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYE-GWYCVsCETFFTESQLVDGGKCPDCGREVELVKEESYFFRMSKY 168
|
170
....*....|
gi 135144 214 APKLKKHLNQ 223
Cdd:PRK12267 169 QDRLLEYYEE 178
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
685-803 |
9.93e-12 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 62.62 E-value: 9.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 685 WDESKIVGIERWLQKVLHLTKNILSLEKDLAISKDYKTPTDlnDAEVKFHndfqRFLKSITESFEvNLSLNTVISDYMKL 764
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAAAELSEEDK--ELRRKLH----KTIKKVTEDIE-RLRFNTAIAALMEL 73
|
90 100 110
....*....|....*....|....*....|....*....
gi 135144 765 TNILESALKKGEVRNEMIVQNLQKLVTVIYPAVPSISEE 803
Cdd:cd07958 74 VNALYKYKKKDAQHAAVLREALETLVLLLAPFAPHIAEE 112
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
55-458 |
4.32e-11 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 66.85 E-value: 4.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 55 FPYP--SGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTRDNIAKMK--------- 123
Cdd:PLN02381 134 LPPPnvTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEfvsevwkwk 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 124 --------QQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVDAQGrswrsg 195
Cdd:PLN02381 214 deyggtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYID------ 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 196 aIVEKKQLKQwflgitkfapklkkhlnqlkdwPSNVKQMQKNwigesvgaeLVFKVADPKFENL---IVFTTRPETLFAV 272
Cdd:PLN02381 288 -IKERTLLKV----------------------PGYDKPVEFG---------VLTSFAYPLEGGLgeiVVATTRIETMLGD 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 273 QYVALaldHPIVQKYCeempdlkefiqksdqlpndtkegfQLPNIKAVNPLTKEEVPIFA-APYVVSSYGSApsAVMGCP 351
Cdd:PLN02381 336 TAIAI---HPDDERYK------------------------HLHGKFAVHPFNGRKLPIICdAILVDPNFGTG--AVKITP 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 352 GHDNRDFEFWQtncpgEHIKTCIAPFFDDAsKVTEQERQRIIDTVPFTSTDGVLT--KECGEHSGV------LTVVARKS 423
Cdd:PLN02381 387 AHDPNDFEVGK-----RHNLEFINIFTDDG-KINSNGGSEFAGMPRFAAREAVIEalQKKGLYRGAknnemrLGLCSRTN 460
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 135144 424 --IMGML------NSEGLSKSVV-----------------------RY--KIRDWLISRQRYWGTPIP 458
Cdd:PLN02381 461 dvVEPMIkpqwfvNCSSMAKQALdaaidgenkklefipkqylaewkRWleNIRDWCISRQLWWGHRIP 528
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
43-670 |
2.07e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 64.58 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 43 TLNSGSKYILCQFPYP--SGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLpAENAAIER-----SINPAIWT 115
Cdd:PLN02943 82 NFDRGGDPFVIPMPPPnvTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI-ATQLVVEKmlaseGIKRTDLG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 116 RDNIAK------------MKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANE 183
Cdd:PLN02943 161 RDEFTKrvwewkekyggtITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDL 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 184 QVdaqgrswrsgaivekkqlkqwflgitkfapklkkhlnQLKDWPSNVKQMQknwigesvgaelvFKVADPKFENLIVFT 263
Cdd:PLN02943 241 EV-------------------------------------EYSEEPGTLYYIK-------------YRVAGGSEDFLTIAT 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 264 TRPETLFAVQYVALALDHPIVQKYCEEMpdlkefiqksdqlpndtkegfqlpnikAVNPLT-KEEVPIFAAPYVVSSYGS 342
Cdd:PLN02943 271 TRPETLFGDVAIAVNPEDDRYSKYIGKM---------------------------AIVPMTyGRHVPIIADRYVDKDFGT 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 343 APSAVMgcPGHDNRDFEFWQT-NCPGEHIKTCIAPFFDDASKVTEQERQRIIDT----------------VPFTSTDGVL 405
Cdd:PLN02943 324 GVLKIS--PGHDHNDYLLARKlGLPILNVMNKDGTLNEVAGLYWFEAREKLWSDleetglavkkephtlrVPRSQRGGEV 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 406 TKECGEHSGVLTV--VARKSIMGMLNSEgLSKSVVRYK---------IRDWLISRQRYWGTPIPI--IHCDNCgpvpvpE 472
Cdd:PLN02943 402 IEPLVSKQWFVTMepLAEKALKAVENGE-LTIIPERFEkiynhwlsnIKDWCISRQLWWGHRIPVwyIVGKDC------E 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 473 SDLPVKLPELEGLDTkgnplstidefvnvACPSCGSPAK--RETDTMDTFIDSSWYYFRFLDPKNTSKpfdrEIASKNMP 550
Cdd:PLN02943 475 EDYIVARSAEEALEK--------------AREKYGKDVEiyQDPDVLDTWFSSALWPFSTLGWPDVSA----EDFKKFYP 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 551 VDIYIGGveHAILHLLYSRFIA---KFLGSInawsdpagifePFKKLVTQGMVQgktyvdpdsgkflkpdeltfvndspd 627
Cdd:PLN02943 537 TTVLETG--HDILFFWVARMVMmgiEFTGTV-----------PFSYVYLHGLIR-------------------------- 577
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 135144 628 gntviiKSNGKvpvvsyeKMSKSKYNGADPNECILRHGPDATR 670
Cdd:PLN02943 578 ------DSQGR-------KMSKTLGNVIDPLDTIKEFGTDALR 607
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
56-165 |
9.06e-08 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 56.13 E-value: 9.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAEnAAIERSINpaIWTRDNIAKM-----KQQMQSML 130
Cdd:PTZ00427 111 PFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIE-YEIEKENN--INKKEDILKMgidvyNEKCRGIV 187
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 135144 131 ANF---------------DWDREITTCDPEYYKFTQWIFLKLFENGLAYR 165
Cdd:PTZ00427 188 LKYsnewvktverigrwiDFKNDYKTMDKTFMESVWWVFSELYKNNYVYK 237
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
56-136 |
2.41e-06 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 47.86 E-value: 2.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTRDNIAKMKQQmqsmlanFDW 135
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKED-------VEY 78
|
.
gi 135144 136 D 136
Cdd:cd00802 79 M 79
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
40-169 |
3.14e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 47.79 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 135144 40 KQDTLNSGSKYILCQ-FPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAiwtrDN 118
Cdd:PLN02224 61 QESTVDEADTFVLTTpLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPP----EH 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 135144 119 IAKMKQQMQSMLANFD--WDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAE 169
Cdd:PLN02224 137 CDIISQSYRTLWKDLDiaYDKFIRTTDPKHEAIVKEFYARVFANGDIYRADYE 189
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
43-88 |
6.39e-05 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 46.57 E-value: 6.39e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 135144 43 TLNSGSKYILCQF--PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVI 88
Cdd:TIGR00456 106 SKKLKNKKIIIEFssANPAGPLHVGHLRNAIIGDSLARILEFLGYDVI 153
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
56-88 |
5.69e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 42.17 E-value: 5.69e-04
10 20 30
....*....|....*....|....*....|...
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVI 88
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
63-89 |
3.91e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 40.86 E-value: 3.91e-03
10 20
....*....|....*....|....*..
gi 135144 63 HIGHLRVYVISDSLNRFYKQKGYNVIH 89
Cdd:COG0215 37 HIGHARTFVVFDVLRRYLRYLGYKVTY 63
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
56-91 |
7.82e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 38.71 E-value: 7.82e-03
10 20 30
....*....|....*....|....*....|....*.
gi 135144 56 PYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPM 91
Cdd:cd00672 28 PTVYDYAHIGHARTYVVFDVLRRYLEDLGYKVRYVQ 63
|
|
| |
