|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
37-453 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
:
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 615.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 37 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 317373584 427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
626-709 |
3.82e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.
:
Pssm-ID: 462325 Cd Length: 84 Bit Score: 106.21 E-value: 3.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 317373584 704 KDCPPG 709
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
990-1084 |
3.53e-25 |
|
Calx-beta domain;
:
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 317373584 1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1642-1727 |
2.51e-21 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 89.78 E-value: 2.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1642 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1721
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 317373584 1722 EGFGPE 1727
Cdd:pfam00041 79 GGEGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1529-1611 |
1.89e-19 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 84.39 E-value: 1.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1529 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1606
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....*
gi 317373584 1607 GWGRE 1611
Cdd:pfam00041 80 GEGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1128-1208 |
6.24e-16 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 6.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 317373584 1204 EGPYS 1208
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1221-1309 |
3.32e-14 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 69.37 E-value: 3.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1221 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1300
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75
|
....*....
gi 317373584 1301 RNGAGWGPE 1309
Cdd:pfam00041 76 VNGGGEGPP 84
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
457-485 |
1.95e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
:
Pssm-ID: 465729 Cd Length: 29 Bit Score: 57.11 E-value: 1.95e-10
10 20
....*....|....*....|....*....
gi 317373584 457 CELQKEVRSARCSFNGDFVCGQCVCSEGW 485
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
550-573 |
1.35e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.35e-03
10 20
....*....|....*....|....*.
gi 317373584 550 LCNDRGRCSM--GQCVCEPGWTGPSC 573
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
37-453 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 615.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 37 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 317373584 427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_beta |
pfam00362 |
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ... |
125-370 |
1.93e-149 |
|
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.
Pssm-ID: 459781 Cd Length: 248 Bit Score: 459.27 E-value: 1.93e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 125 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 200
Cdd:pfam00362 1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 201 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 280
Cdd:pfam00362 81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 281 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 360
Cdd:pfam00362 159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238
|
250
....*....|
gi 317373584 361 EAFNRIRSNL 370
Cdd:pfam00362 239 EAYEKIRSKV 248
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
626-709 |
3.82e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.
Pssm-ID: 462325 Cd Length: 84 Bit Score: 106.21 E-value: 3.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 317373584 704 KDCPPG 709
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
990-1084 |
3.53e-25 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 317373584 1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
991-1084 |
2.82e-23 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 95.40 E-value: 2.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 991 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1070
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78
|
90
....*....|....
gi 317373584 1071 LRGrqVRRFHVQLS 1084
Cdd:smart00237 79 YEK--DETFYVRLS 90
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1642-1727 |
2.51e-21 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 89.78 E-value: 2.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1642 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1721
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 317373584 1722 EGFGPE 1727
Cdd:pfam00041 79 GGEGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1529-1611 |
1.89e-19 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 84.39 E-value: 1.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1529 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1606
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....*
gi 317373584 1607 GWGRE 1611
Cdd:pfam00041 80 GEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1528-1609 |
2.01e-19 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 84.86 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1528 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1606
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
...
gi 317373584 1607 GWG 1609
Cdd:cd00063 81 GES 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1641-1726 |
3.84e-17 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 78.31 E-value: 3.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1641 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQART 1720
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78
|
....*.
gi 317373584 1721 TEGFGP 1726
Cdd:cd00063 79 GGGESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1128-1208 |
6.24e-16 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 6.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 317373584 1204 EGPYS 1208
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1528-1609 |
1.87e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 73.03 E-value: 1.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1528 PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRLN--IPNPAQTSVVVEDLLPNHSYVFRVRAQSQ 1605
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
....
gi 317373584 1606 EGWG 1609
Cdd:smart00060 80 AGEG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1641-1725 |
9.83e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 71.11 E-value: 9.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1641 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQART 1720
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 317373584 1721 TEGFG 1725
Cdd:smart00060 79 GAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1221-1309 |
3.32e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 69.37 E-value: 3.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1221 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1300
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75
|
....*....
gi 317373584 1301 RNGAGWGPE 1309
Cdd:pfam00041 76 VNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1220-1313 |
3.86e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.83 E-value: 3.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....
gi 317373584 1300 ARNGAGWGPEREAI 1313
Cdd:cd00063 76 AVNGGGESPPSESV 89
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1527-1746 |
5.76e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 76.96 E-value: 5.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1527 VPDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRlnIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1606
Cdd:COG3401 232 PPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1607 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVTcemaQGGG 1685
Cdd:COG3401 309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 317373584 1686 PATAFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLG 1746
Cdd:COG3401 366 GGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1128-1215 |
2.76e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 67.14 E-value: 2.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1128 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 317373584 1204 EGPYSSLVSCRT 1215
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
457-485 |
1.95e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 57.11 E-value: 1.95e-10
10 20
....*....|....*....|....*....
gi 317373584 457 CELQKEVRSARCSFNGDFVCGQCVCSEGW 485
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
992-1106 |
5.81e-10 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 64.43 E-value: 5.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1068
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 317373584 1069 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1106
Cdd:TIGR00845 482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1128-1205 |
1.73e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 1.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1128 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 317373584 1204 EG 1205
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1220-1307 |
2.32e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
....*...
gi 317373584 1300 ARNGAGWG 1307
Cdd:smart00060 76 AVNGAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1579-1723 |
3.57e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.48 E-value: 3.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1579 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1657
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373584 1658 QLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1723
Cdd:COG3401 250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1146-1305 |
2.09e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 52.70 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1146 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1225
Cdd:COG3401 159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1226 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401 239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
550-573 |
1.35e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.35e-03
10 20
....*....|....*....|....*.
gi 317373584 550 LCNDRGRCSM--GQCVCEPGWTGPSC 573
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
37-453 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 615.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 37 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 317373584 427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_beta |
pfam00362 |
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ... |
125-370 |
1.93e-149 |
|
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.
Pssm-ID: 459781 Cd Length: 248 Bit Score: 459.27 E-value: 1.93e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 125 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 200
Cdd:pfam00362 1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 201 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 280
Cdd:pfam00362 81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 281 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 360
Cdd:pfam00362 159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238
|
250
....*....|
gi 317373584 361 EAFNRIRSNL 370
Cdd:pfam00362 239 EAYEKIRSKV 248
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
626-709 |
3.82e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.
Pssm-ID: 462325 Cd Length: 84 Bit Score: 106.21 E-value: 3.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 317373584 704 KDCPPG 709
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
990-1084 |
3.53e-25 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 317373584 1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
991-1084 |
2.82e-23 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 95.40 E-value: 2.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 991 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1070
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78
|
90
....*....|....
gi 317373584 1071 LRGrqVRRFHVQLS 1084
Cdd:smart00237 79 YEK--DETFYVRLS 90
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1642-1727 |
2.51e-21 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 89.78 E-value: 2.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1642 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1721
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 317373584 1722 EGFGPE 1727
Cdd:pfam00041 79 GGEGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1529-1611 |
1.89e-19 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 84.39 E-value: 1.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1529 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1606
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....*
gi 317373584 1607 GWGRE 1611
Cdd:pfam00041 80 GEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1528-1609 |
2.01e-19 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 84.86 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1528 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1606
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
...
gi 317373584 1607 GWG 1609
Cdd:cd00063 81 GES 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1641-1726 |
3.84e-17 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 78.31 E-value: 3.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1641 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQART 1720
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78
|
....*.
gi 317373584 1721 TEGFGP 1726
Cdd:cd00063 79 GGGESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1128-1208 |
6.24e-16 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 6.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 317373584 1204 EGPYS 1208
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1528-1609 |
1.87e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 73.03 E-value: 1.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1528 PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRLN--IPNPAQTSVVVEDLLPNHSYVFRVRAQSQ 1605
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
....
gi 317373584 1606 EGWG 1609
Cdd:smart00060 80 AGEG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1641-1725 |
9.83e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 71.11 E-value: 9.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1641 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQART 1720
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 317373584 1721 TEGFG 1725
Cdd:smart00060 79 GAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1221-1309 |
3.32e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 69.37 E-value: 3.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1221 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1300
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75
|
....*....
gi 317373584 1301 RNGAGWGPE 1309
Cdd:pfam00041 76 VNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1220-1313 |
3.86e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.83 E-value: 3.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....
gi 317373584 1300 ARNGAGWGPEREAI 1313
Cdd:cd00063 76 AVNGGGESPPSESV 89
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1527-1746 |
5.76e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 76.96 E-value: 5.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1527 VPDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRlnIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1606
Cdd:COG3401 232 PPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1607 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVTcemaQGGG 1685
Cdd:COG3401 309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 317373584 1686 PATAFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLG 1746
Cdd:COG3401 366 GGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1128-1215 |
2.76e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 67.14 E-value: 2.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1128 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 317373584 1204 EGPYSSLVSCRT 1215
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| PSI_integrin |
pfam17205 |
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ... |
28-73 |
9.43e-11 |
|
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.
Pssm-ID: 465380 Cd Length: 47 Bit Score: 58.33 E-value: 9.43e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 317373584 28 NRCKKApVKSCTECVRVDKDCAYCTDEMF--RDRRCNTQAELLAAGCQ 73
Cdd:pfam17205 1 NRCTSA-STSCEECIQSGPDCAWCTDENFtsGSPRCDTRENLLARGCS 47
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1129-1305 |
1.92e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 65.79 E-value: 1.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1129 APQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--------YEMKVCAY 1199
Cdd:COG3401 235 APTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgltngttYYYRVTAV 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1200 GAQG-EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVCYglvndDNRPIGPMKKVlVDNP 1278
Cdd:COG3401 306 DAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYR-----STSGGGTYTKI-AETV 377
|
170 180
....*....|....*....|....*..
gi 317373584 1279 KNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401 378 TTTSYTDTGLTPGTTYYYKVTAVDAAG 404
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
457-485 |
1.95e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 57.11 E-value: 1.95e-10
10 20
....*....|....*....|....*....
gi 317373584 457 CELQKEVRSARCSFNGDFVCGQCVCSEGW 485
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
992-1106 |
5.81e-10 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 64.43 E-value: 5.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1068
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 317373584 1069 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1106
Cdd:TIGR00845 482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1128-1205 |
1.73e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 1.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1128 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 317373584 1204 EG 1205
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1220-1307 |
2.32e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
....*...
gi 317373584 1300 ARNGAGWG 1307
Cdd:smart00060 76 AVNGAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1579-1723 |
3.57e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.48 E-value: 3.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1579 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1657
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373584 1658 QLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1723
Cdd:COG3401 250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1146-1305 |
2.09e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 52.70 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1146 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1225
Cdd:COG3401 159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 1226 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401 239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
978-1087 |
2.14e-06 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 52.87 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373584 978 LVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKE 1056
Cdd:TIGR00845 516 TATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKT 595
|
90 100 110
....*....|....*....|....*....|.
gi 317373584 1057 LQVKLLELQEVDsllrgRQVrRFHVQLSNPK 1087
Cdd:TIGR00845 596 IRVKIVDDEEYE-----KND-TFFIELGEPR 620
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
550-573 |
1.35e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.35e-03
10 20
....*....|....*....|....*.
gi 317373584 550 LCNDRGRCSM--GQCVCEPGWTGPSC 573
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| |
