|
Name |
Accession |
Description |
Interval |
E-value |
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
206-972 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1154.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDST 365
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 366 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRSKG 445
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERP-PEEGWEDQLCHKLKRNRKAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 446 RRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSP 524
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 525 LIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVS-DRLNIGIVHVGA 603
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEaSRLRIAIIHVGA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 604 PSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIqTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNK 683
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLA-RHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 684 LDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFV 763
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 764 CEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDkgenRNGKLLVRNEQASSVYSTQLLADIIS 843
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 844 EASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAkvlrfkfdthgekvptvehEDDS 923
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSA-------------------DDTS 695
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 125121 924 AAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGR 972
Cdd:TIGR02478 696 AVVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGR 744
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
204-954 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1143.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFR 283
Cdd:cd00764 2 AGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 284 KREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTD 363
Cdd:cd00764 82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 364 STIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRS 443
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERP-PEDGWEDQMCRRLSEHRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 444 KGRRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETP 522
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVErLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 523 SPLIGILENKIIRMPLVESVKLTKSV-----------ATAIENKDFDKAISLRDTEFIELYenflsttvkddgsELLPVS 591
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVqkamdekrfdeAAALRGKSFDKNWNLYKLLAIELP-------------QPLPEK 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 592 DRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVASED 671
Cdd:cd00764 388 TNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAK-GQIVELGWIDVGGWTGRGGSELGTKRTLPKKD 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 672 LGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIK 751
Cdd:cd00764 467 LETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIK 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 752 QSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASS 831
Cdd:cd00764 547 QSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTT 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 832 VYSTQLLADIIseasKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFK----- 906
Cdd:cd00764 627 VFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNcvngv 702
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 125121 907 -----FDTHGE--KVPTVEH----EDDSAAVICVNGSHVSFKPIANLWENETNVELRKG 954
Cdd:cd00764 703 kkyavLFEPVEelKQTTFEHripkEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRG 761
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
207-512 |
5.22e-137 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 411.73 E-value: 5.22e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 207 KIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIGTARSMEFRKRE 286
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 287 GRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWpslvdelvaegrftkeevapykNLSIVGLVGSIDNDMSGTDSTI 366
Cdd:pfam00365 79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 367 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVphgkwqdELKEVCQ--RHRSK 444
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF-------DIEELCEkiKELRK 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125121 445 GRRNNTIIVAEGALDdqlnpvtANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVK 512
Cdd:pfam00365 210 GKRFSIIVVAEGASD-------GEFLAKLIEEgTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
206-548 |
1.64e-116 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 360.16 E-value: 1.64e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGA-DLFRHEWPslvdelvaegrftkeevapyknlsIVGLVGSIDNDMSGTDS 364
Cdd:PRK03202 80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAkRLTEHGIP------------------------VIGLPGTIDNDIAGTDY 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHgkwqDELKEVCQRHRSK 444
Cdd:PRK03202 136 TIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDI----EELCAKIKKGRER 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 445 GRRNNTIIVAEGALDdqlnpvtANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEftpETPS 523
Cdd:PRK03202 212 GKKHAIIVVAEGVMP-------AEELAKEIEErTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGG 281
|
330 340
....*....|....*....|....*
gi 125121 524 PLIGILENKIIRMPLVESVKLTKSV 548
Cdd:PRK03202 282 RMVGIQNNKIVHVPIEEAVENMKHP 306
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
205-548 |
1.41e-114 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 355.92 E-value: 1.41e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 205 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIGTARSMEFRK 284
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD--IIDLTREDVSGILQRGGTILGSSRSKPFKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 285 REGRRQAAGNLISQGIDALVVCGGDGSLTGADLFrHEwpslvdelvaegrftkeevapYKNLSIVGLVGSIDNDMSGTDS 364
Cdd:COG0205 79 EEGREKALENLKKLGIDALVVIGGDGSLDGAAKL-AE---------------------EYGIPVVGIPKTIDNDLPGTDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPhgkwQDELKEVCQRHRSK 444
Cdd:COG0205 137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 445 GRRNNTIIVAEGALDDQLNPV---------------TANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGV 508
Cdd:COG0205 213 GKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEErTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 125121 509 DAVKAVLEftpETPSPLIGILENKIIRMPLVESVKLTKSV 548
Cdd:COG0205 293 AAVELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| Pfk_N |
pfam18468 |
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ... |
8-101 |
1.79e-31 |
|
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).
Pssm-ID: 408261 Cd Length: 98 Bit Score: 118.40 E-value: 1.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 8 YGVAFRSIITNDEALFKKTIHFYHTLGFATVKDFNKFKHGENSLLssGTSQDSLREVWLESFKLSEVDASGFRIPQQEAT 87
Cdd:pfam18468 1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFELI--GVSTDSIKEIWLESFPLSEVDSHGFRIPWQESP 78
|
90 100
....*....|....*....|
gi 125121 88 N------KAQSQGALLKIRL 101
Cdd:pfam18468 79 GyqgdysPKLSDGVVIKLRL 98
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
206-972 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1154.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDST 365
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 366 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRSKG 445
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERP-PEEGWEDQLCHKLKRNRKAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 446 RRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSP 524
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 525 LIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVS-DRLNIGIVHVGA 603
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEaSRLRIAIIHVGA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 604 PSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIqTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNK 683
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLA-RHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 684 LDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFV 763
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 764 CEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDkgenRNGKLLVRNEQASSVYSTQLLADIIS 843
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 844 EASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAkvlrfkfdthgekvptvehEDDS 923
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSA-------------------DDTS 695
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 125121 924 AAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGR 972
Cdd:TIGR02478 696 AVVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGR 744
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
204-954 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1143.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFR 283
Cdd:cd00764 2 AGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 284 KREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTD 363
Cdd:cd00764 82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 364 STIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRS 443
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERP-PEDGWEDQMCRRLSEHRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 444 KGRRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETP 522
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVErLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 523 SPLIGILENKIIRMPLVESVKLTKSV-----------ATAIENKDFDKAISLRDTEFIELYenflsttvkddgsELLPVS 591
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVqkamdekrfdeAAALRGKSFDKNWNLYKLLAIELP-------------QPLPEK 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 592 DRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVASED 671
Cdd:cd00764 388 TNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAK-GQIVELGWIDVGGWTGRGGSELGTKRTLPKKD 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 672 LGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIK 751
Cdd:cd00764 467 LETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIK 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 752 QSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASS 831
Cdd:cd00764 547 QSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTT 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 832 VYSTQLLADIIseasKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFK----- 906
Cdd:cd00764 627 VFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNcvngv 702
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 125121 907 -----FDTHGE--KVPTVEH----EDDSAAVICVNGSHVSFKPIANLWENETNVELRKG 954
Cdd:cd00764 703 kkyavLFEPVEelKQTTFEHripkEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRG 761
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
206-562 |
4.43e-165 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 486.81 E-value: 4.43e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLvdelvaegrftkeevapYKNLSIVGLVGSIDNDMSGTDST 365
Cdd:cd00363 79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSK-----------------YQGFNVIGLPGTIDNDIKGTDYT 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 366 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERaVPHGKWQDELKEVCQRHRSKG 445
Cdd:cd00363 142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEE-PAADEWEEEMVDVIKKRRERG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 446 RRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSP 524
Cdd:cd00363 221 KRHGIVIVAEGAIDFIPKPITEKLLAKLVEErLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVG 300
|
330 340 350
....*....|....*....|....*....|....*...
gi 125121 525 LIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAIS 562
Cdd:cd00363 301 IQNLNENQVVRHPLTEAVNMTKRVGVDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
207-512 |
5.22e-137 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 411.73 E-value: 5.22e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 207 KIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIGTARSMEFRKRE 286
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 287 GRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWpslvdelvaegrftkeevapykNLSIVGLVGSIDNDMSGTDSTI 366
Cdd:pfam00365 79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 367 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVphgkwqdELKEVCQ--RHRSK 444
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF-------DIEELCEkiKELRK 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125121 445 GRRNNTIIVAEGALDdqlnpvtANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVK 512
Cdd:pfam00365 210 GKRFSIIVVAEGASD-------GEFLAKLIEEgTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
206-548 |
1.64e-116 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 360.16 E-value: 1.64e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGA-DLFRHEWPslvdelvaegrftkeevapyknlsIVGLVGSIDNDMSGTDS 364
Cdd:PRK03202 80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAkRLTEHGIP------------------------VIGLPGTIDNDIAGTDY 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHgkwqDELKEVCQRHRSK 444
Cdd:PRK03202 136 TIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDI----EELCAKIKKGRER 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 445 GRRNNTIIVAEGALDdqlnpvtANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEftpETPS 523
Cdd:PRK03202 212 GKKHAIIVVAEGVMP-------AEELAKEIEErTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGG 281
|
330 340
....*....|....*....|....*
gi 125121 524 PLIGILENKIIRMPLVESVKLTKSV 548
Cdd:PRK03202 282 RMVGIQNNKIVHVPIEEAVENMKHP 306
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
205-548 |
1.41e-114 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 355.92 E-value: 1.41e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 205 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIGTARSMEFRK 284
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD--IIDLTREDVSGILQRGGTILGSSRSKPFKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 285 REGRRQAAGNLISQGIDALVVCGGDGSLTGADLFrHEwpslvdelvaegrftkeevapYKNLSIVGLVGSIDNDMSGTDS 364
Cdd:COG0205 79 EEGREKALENLKKLGIDALVVIGGDGSLDGAAKL-AE---------------------EYGIPVVGIPKTIDNDLPGTDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPhgkwQDELKEVCQRHRSK 444
Cdd:COG0205 137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 445 GRRNNTIIVAEGALDDQLNPV---------------TANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGV 508
Cdd:COG0205 213 GKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEErTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 125121 509 DAVKAVLEftpETPSPLIGILENKIIRMPLVESVKLTKSV 548
Cdd:COG0205 293 AAVELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
207-542 |
4.49e-99 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 313.52 E-value: 4.49e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 207 KIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKRE 286
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 287 GRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEwpslvdelvaegrftkeevapyKNLSIVGLVGSIDNDMSGTDSTI 366
Cdd:TIGR02482 79 VREKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE----------------------GGIPVIGLPGTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 367 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHgkwqDELKEVCQRHRSKGR 446
Cdd:TIGR02482 137 GFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDI----DELIQRLKEQHEAGK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 447 RNNTIIVAEGALDDQLNPVtANDVKDAlieLGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETpspLI 526
Cdd:TIGR02482 213 KHSIIIVAEGNIVGSAKEV-AKKIEEK---TGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MI 285
|
330
....*....|....*.
gi 125121 527 GILENKIIRMPLVESV 542
Cdd:TIGR02482 286 GIQNNKIVTHPIEEAL 301
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
595-883 |
2.00e-93 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 297.33 E-value: 2.00e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 595 NIGIVHVGAPSaalnaatraaTLYCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVAS---ED 671
Cdd:pfam00365 1 RIGILTSGGDApgmnaairavVRTAIYRGHEVYGIRNGYEGLVE-GDIDELTWRDVSGILNRGGTILGTSRSKPFkteEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 672 LGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRtqhpifNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIK 751
Cdd:pfam00365 80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEER------GIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 752 QSASATrRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHdkgenrngKLLVRNEQASs 831
Cdd:pfam00365 154 DTASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKGKRF--------SIIVVAEGAS- 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 125121 832 vySTQLLADIISEasKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIK 883
Cdd:pfam00365 224 --DGEFLAKLIEE--GTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
206-561 |
1.49e-84 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 275.44 E-value: 1.49e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGA-DLFRHEWPSlvdelvaegrftkeevapyknlsiVGLVGSIDNDMSGTDS 364
Cdd:cd00763 79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAmRLTEHGFPC------------------------VGLPGTIDNDIPGTDY 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPhgkwQDELKEVCQRHRSK 444
Cdd:cd00763 135 TIGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD----REEVANRIKAGIER 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 445 GRRNNTIIVAEGALD-DQLnpvtANDVKDAlieLGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEftpETPS 523
Cdd:cd00763 211 GKKHAIVVVAEGVYDvDEL----AKEIEEA---TGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLA---GKGG 280
|
330 340 350
....*....|....*....|....*....|....*....
gi 125121 524 PLIGILENKIIRMPLVEsvkltksvatAIEN-KDFDKAI 561
Cdd:cd00763 281 LAVGIQNEQLVHHDIID----------AIENmKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
207-542 |
2.49e-79 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 261.47 E-value: 2.49e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 207 KIAVMTSGGDSPGMNAAVRAVVRTGIH-FGCDVFAVYEGYEGLLRGgKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRK- 284
Cdd:TIGR02483 1 RIGVLTGGGDCPGLNAVIRGVVRRAIAeYGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKYe 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 285 REGRRQAAGNLISQGIDALVVCGGDGSLTGAdlfrhewpslvdelvaeGRFTKeevapyKNLSIVGLVGSIDNDMSGTDS 364
Cdd:TIGR02483 80 EDGDDKIVANLKELGLDALIAIGGDGTLGIA-----------------RRLAD------KGLPVVGVPKTIDNDLEATDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERavpHGKWQDELKEVCQRhRSK 444
Cdd:TIGR02483 137 TFGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEI---PFDIDSVCEKVRER-FAR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 445 GRRNNTIIVAEGALDDQLNPVTANDVKDA---------------LIE--LGLDTKVTILGHVQRGGTAVAHDRWLATLQG 507
Cdd:TIGR02483 213 GKRFAIVVVAEGAKPKGGEMVVQEGVKDAfghvrlggignwlaeEIErrTGIETRATVLGHLQRGGSPSAFDRVLATRFG 292
|
330 340 350
....*....|....*....|....*....|....*
gi 125121 508 VDAVKAVLEFTPETPSPLIGileNKIIRMPLVESV 542
Cdd:TIGR02483 293 VAAVDLVHEGQFGHMVALRG---TDIVYVPIAEAV 324
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
204-511 |
2.11e-52 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 187.97 E-value: 2.11e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTGI-HFGCDVFAVYEGYEGLL-RGGKYLKkMAWEDVRGWLSEGGTLIGTA---- 277
Cdd:PRK14071 3 EKKRIGILTSGGDCAGLNAVIRAVVHRARgTYGWEVIGIRDATQGLMaRPPQYIE-LDLDQVDDLLRMGGTILGTTnkgd 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 278 -------------RSMEFRkrEGRRQAagnlisqGIDALVVCGGDGSLtgadlfrhewpSLVDELVAEGrftkeevapyk 344
Cdd:PRK14071 82 pfafpmpdgslrdRSQEII--DGYHSL-------GLDALIGIGGDGSL-----------AILRRLAQQG----------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 345 NLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPEra 424
Cdd:PRK14071 131 GINLVGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPE-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 425 VPHgKWQDELKEVCQRhRSKGRRNNTIIVAEGALDDQLNPVT-----------------ANDVKDAlieLGLDTKVTILG 487
Cdd:PRK14071 209 IPY-TLENVCKKIRER-QEEGKNFCLVVVSEAVRTEEGEQVTktqalgedryggigqylAEQIAER---TGAETRVTVLG 283
|
330 340
....*....|....*....|....
gi 125121 488 HVQRGGTAVAHDRWLATLQGVDAV 511
Cdd:PRK14071 284 HIQRGGIPSPRDRLLASAFGVAAV 307
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
196-524 |
7.91e-49 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 186.01 E-value: 7.91e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 196 RQTLGSSQKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIG 275
Cdd:TIGR02478 380 KKLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELG 457
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 276 TARSMEFRKREgrrQAAGNLISQGIDALVVCGGDGSLTGA---DLFRHEWPSLvdelvaegrftkeevapykNLSIVGLV 352
Cdd:TIGR02478 458 TNRSLPGDDLG---TIAYYFQQHKIDGLIIIGGFEAFEALyqlDAAREKYPAF-------------------RIPMVVIP 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 353 GSIDNDMSGTDSTIGAYSALERICEMVDYIDATAK-SHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQ 431
Cdd:TIGR02478 516 ATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQ 595
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 432 ---DELKEVCQRHRSKGrrnnTIIVAEGALDDqlnpVTANDVKDALIELG---LDTKVTILGHVQRGGTAVAHDRWLATL 505
Cdd:TIGR02478 596 ediEHLKETFAEGRAGK----LILRNEKASKV----YTTDFIARIISEEGkgrFDARTAVLGHMQQGGSPSPFDRVRATR 667
|
330
....*....|....*....
gi 125121 506 QGVDAVKAVLEFTPETPSP 524
Cdd:TIGR02478 668 LAIRAVDFIEEKIKANKHA 686
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
616-887 |
1.80e-43 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 161.40 E-value: 1.80e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 616 TLYCLSHGHKPYAIMNGFSGLIqTGEVKELSWIDVENWHNLGGSEIGTNRS---VASEDLGTIAYYFQKNKLDGLIILGG 692
Cdd:COG0205 24 VRTAIKYGIEVYGIRDGYEGLL-EGDIIDLTREDVSGILQRGGTILGSSRSkpfKTEEGREKALENLKKLGIDALVVIGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 693 fEG-FRSLKQLRDgrtqhpIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATrRRVFVCEVQGGHS 771
Cdd:COG0205 103 -DGsLDGAAKLAE------EYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAASH-ERVFVVEVMGRHA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 772 GYIASFTGLITGAVSVYTPEKKIDLASIREDItllKENFRHDKG----------ENRNGKLLVRNEQASSVY-----STQ 836
Cdd:COG0205 175 GWLALAAGLAGGADLILIPEVPFDLDKLLEKL---KERRKRGKGysiivvaegaGDEDGEAVLEADTDAFGHvrlggIGE 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 125121 837 LLADIISEASKGKfgVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQ 887
Cdd:COG0205 252 YLAKEIEERTGIE--TRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
618-887 |
2.93e-39 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 148.69 E-value: 2.93e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 618 YCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGT---IAYYFQKNKLDGLIILGGfE 694
Cdd:PRK03202 26 TAISEGLEVYGIYDGYAGLLE-GDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGrakAIENLKKLGIDALVVIGG-D 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 695 G-FRSLKQLRDGrtqhpifNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASAtRRRVFVCEVQGGHSGY 773
Cdd:PRK03202 104 GsYMGAKRLTEH-------GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASS-HERVFIVEVMGRHAGD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 774 IASFTGLITGAVSVYTPEKKIDLASIREDItllKENFRHDKgenRNGKLLVrneqASSVYSTQLLADIISEasKGKFGVR 853
Cdd:PRK03202 176 LALHAGIAGGAEVILIPEVPFDIEELCAKI---KKGRERGK---KHAIIVV----AEGVMPAEELAKEIEE--RTGLETR 243
|
250 260 270
....*....|....*....|....*....|....
gi 125121 854 TAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQ 887
Cdd:PRK03202 244 VTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE 277
|
|
| Pfk_N |
pfam18468 |
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ... |
8-101 |
1.79e-31 |
|
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).
Pssm-ID: 408261 Cd Length: 98 Bit Score: 118.40 E-value: 1.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 8 YGVAFRSIITNDEALFKKTIHFYHTLGFATVKDFNKFKHGENSLLssGTSQDSLREVWLESFKLSEVDASGFRIPQQEAT 87
Cdd:pfam18468 1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFELI--GVSTDSIKEIWLESFPLSEVDSHGFRIPWQESP 78
|
90 100
....*....|....*....|
gi 125121 88 N------KAQSQGALLKIRL 101
Cdd:pfam18468 79 GyqgdysPKLSDGVVIKLRL 98
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
620-878 |
8.35e-31 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 124.06 E-value: 8.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 620 LSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRS--VASEDLGTIAY-YFQKNKLDGLIILGGFEGF 696
Cdd:cd00763 27 IAEGLEVYGIRDGYAGLIA-GDIVPLDRYSVSDIINRGGTFLGSARFpeFKDEEGQAKAIeQLKKHGIDALVVIGGDGSY 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 697 RSLKQLrdgrTQHpifNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASaTRRRVFVCEVQGGHSGYIAS 776
Cdd:cd00763 106 MGAMRL----TEH---GFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSS-SHQRISVVEVMGRHCGDIAL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 777 FTGLITGAVSVYTPEKKIDLASIREDITLLkenfrHDKGEnRNGKLLVrneqASSVYSTQLLADIISEasKGKFGVRTAI 856
Cdd:cd00763 178 AAGIAGGAEFIVIPEAEFDREEVANRIKAG-----IERGK-KHAIVVV----AEGVYDVDELAKEIEE--ATGFETRATV 245
|
250 260
....*....|....*....|..
gi 125121 857 PGHVQQGGVPSSKDRVTASRFA 878
Cdd:cd00763 246 LGHIQRGGSPTAFDRILASRMG 267
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
594-879 |
1.91e-30 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 123.56 E-value: 1.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 594 LNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVASED-- 671
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVE-GDIKELDWESVSDIINRGGTIIGSARCKEFRTee 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 672 -LGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIfNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDI 750
Cdd:cd00363 80 gRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQ-GFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 751 KQSASaTRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKEnfRHDKGEnRNGKLLVRN---E 827
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKK--RRERGK-RHGIVIVAEgaiD 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 125121 828 QASSVYSTQLLADIISEasKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAV 879
Cdd:cd00363 235 FIPKPITEKLLAKLVEE--RLGFDTRATVLGHVQRGGTPTAFDRILASRLGA 284
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
204-473 |
7.64e-25 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 108.98 E-value: 7.64e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTGIH-FGC-DVFAVYEGYEGLLRGGKYlkKMAWEDVRGWLSEGGTLIGTARSME 281
Cdd:PTZ00286 86 KEVKAGIVTCGGLCPGLNVVIRELVMNLINnYGVkTIYGAKYGYKGLYKEDWI--KLDPKDVKTIHRLGGTILGSSRGGF 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 282 FRKregrrQAAGNLISQGIDALVVCGGDGSLTGADlfrhewpslvdELVAEGRFTKEevapykNLSIVGLVGSIDNDMSG 361
Cdd:PTZ00286 164 DPK-----VMVDTLIRHGINILFTLGGDGTHRGAL-----------AIYKELRRRKL------NISVVGIPKTIDNDIPI 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 362 TDSTIGAYSALERICEMVDYIDATAKSHSRAF-VVEVMGRHCGWLALMAGIATG-ADYIFIPERAVPhgkwqdeLKEVCQ 439
Cdd:PTZ00286 222 IDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIP-------LEGVLE 294
|
250 260 270
....*....|....*....|....*....|....*.
gi 125121 440 --RHRSKGRRNNTIIVAEGALDDQLnPVTANDVKDA 473
Cdd:PTZ00286 295 yiEQRLQKKGHCVIVVAEGAGQSLK-DADLDLGTDA 329
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
622-887 |
2.05e-21 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 97.06 E-value: 2.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 622 HGHKPYAIMNGFSGLIQTG-EVKELSWIDVENWHNLGGSEIGT-NR-----------SVASEDLGTIAYYFQKNkLDGLI 688
Cdd:PRK14071 34 YGWEVIGIRDATQGLMARPpQYIELDLDQVDDLLRMGGTILGTtNKgdpfafpmpdgSLRDRSQEIIDGYHSLG-LDALI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 689 ILGGFEGFRSLKQLRDgrtqhpIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSAsATRRRVFVCEVQG 768
Cdd:PRK14071 113 GIGGDGSLAILRRLAQ------QGGINLVGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTA-ASHNRVMILEVMG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 769 GHSGYIASFTGLITGAVSVYTPEKKIDLASIREDItllkenfRHDKGENRNGKLL-----VRNEQASSVYST-------- 835
Cdd:PRK14071 186 RDAGHIALAAGIAGGADVILIPEIPYTLENVCKKI-------RERQEEGKNFCLVvvseaVRTEEGEQVTKTqalgedry 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 125121 836 ----QLLADIISEASKGKfgVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQ 887
Cdd:PRK14071 259 ggigQYLAEQIAERTGAE--TRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
207-548 |
4.40e-19 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 91.03 E-value: 4.40e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 207 KIAVMTSGGDSPGMNAAVRAVVRTGIHFGC-DVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTAR------- 278
Cdd:PLN02884 55 KAAIVTCGGLCPGLNDVIRQIVFTLEIYGVkNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSRggaktsd 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 279 ---SMEFRkregrrqaagnlisqGIDALVVCGGDGSLTGADLFrHEwpslvdelvaEGRFTKEEVapyknlSIVGLVGSI 355
Cdd:PLN02884 135 ivdSIEAR---------------GINMLFVLGGNGTHAGANAI-HN----------ECRKRKMKV------SVVGVPKTI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 356 DNDMSGTDSTIGAYSALERICEMVD--YIDATAKSHSRAfVVEVMGRHCGWLALMAGIATG-ADYIFIPERAV----PHG 428
Cdd:PLN02884 183 DNDILLMDKTFGFDTAVEEAQRAINsaYIEAHSAYHGIG-LVKLMGRSSGFIAMHASLASGqVDICLIPEVPFtldgPNG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 429 KWQdELKEVCQrhrSKGRrnNTIIVAEGALDDQLNPVTAND-----------------VKDALIELGL--DTKVTILGHV 489
Cdd:PLN02884 262 VLR-HLEHLIE---TKGS--AVVCVAEGAGQDLLQKTNATDasgnpvlgdigvhlqqeIKKHFKDIGVpaDVKYIDPTYM 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 490 QRGGTAVAHDRWLATLQGVDAVKAVLE-FTPETpsplIGILENKIIRMPLVESVKLTKSV 548
Cdd:PLN02884 336 IRACRANASDAILCTVLGQNAVHGAFAgFSGIT----VGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
205-457 |
1.62e-18 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 88.91 E-value: 1.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 205 KKKIAVMTSGGDSPGMNAAVRAVVR--TGIHFGCDVFAVYEGYEGLLRGGKYLKKmawEDVRG----WLSEGGTLIGTAR 278
Cdd:PRK06555 3 VKKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLLLGDSIEIT---PAVRAnaglLHRYGGSPIGNSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 279 -----SMEFRKR----EGR---RQAAGNLISQGIDALVVCGGDGS-LTGADLFRHewpslvdeLVAEGrftkeevapYkN 345
Cdd:PRK06555 80 vkltnVADCVKRglvkEGEnplKVAAERLAADGVDILHTIGGDDTnTTAADLAAY--------LAENG---------Y-D 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 346 LSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVV-EVMGRHCGWLAlmagIATGADY------- 417
Cdd:PRK06555 142 LTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLT----AATARAYrewldrq 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 125121 418 -----------------IFIPERAVPHGKWQDELKEVCQRHrskgrRNNTIIVAEGA 457
Cdd:PRK06555 218 eyvpgfglsaerwdihaVYLPEMAFDLEAEAERLKAVMDEV-----GNVNIFLSEGA 269
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
355-495 |
2.09e-15 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 79.52 E-value: 2.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 355 IDNDMSGTDSTIGAYSALERICE--MVDYIDATA-KSHSRAFVVEVMGRHCGWLALMAGIAT-----GADYIFIPERAVP 426
Cdd:PRK14072 142 IDNDLPGTDHCPGFGSAAKYIATsvLEAALDVAAmANTSKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERPFD 221
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 427 HGKWQDELKEVCQRHrskGRrnNTIIVAEGALDDQLNPVT-ANDVKDAlielgldtkvtiLGHVQRGGTA 495
Cdd:PRK14072 222 EEKFLADVRAIVKRY---GY--CVVVVSEGIRDADGKFIAeAGLAEDA------------FGHAQLGGVA 274
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
204-457 |
2.35e-14 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 76.45 E-value: 2.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTgIHFGCDVFAVY---EGYEGLL-RGGKYLKKMAWEDVRGWLSEGGTLIGTARS 279
Cdd:PRK06830 79 SKVKAAIVTCGGLCPGLNDVIRAIVLE-LHHHYGVRRILgirYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSRG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 280 MefrkregrrQAAG----NLISQGIDALVVCGGDGSLTGADlfrhewpSLVDELVAEGRftkeevapykNLSIVGLVGSI 355
Cdd:PRK06830 158 P---------QDPEeivdTLERMNINILFVIGGDGTLRGAS-------AIAEEIERRGL----------KISVIGIPKTI 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 356 DNDMSGTDSTIGAYSALERICEmvdyidATAKSHSRAF-------VVEVMGRHCGWLALMAGIATG-ADYIFIPEraVP- 426
Cdd:PRK06830 212 DNDINFIQKSFGFETAVEKATE------AIRCAHVEANgapngigLVKLMGRHSGFIAAYAALASKdVNFVLIPE--VPf 283
|
250 260 270
....*....|....*....|....*....|...
gi 125121 427 --HGkwQDELKEVCQRhRSKGRRNNTIIVAEGA 457
Cdd:PRK06830 284 dlEG--PNGLLAALEK-RLAERGHAVIVVAEGA 313
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
627-803 |
9.03e-12 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 68.53 E-value: 9.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 627 YAIMNGFSGLIQTGEVKeLSWIDVENWHNLGGSEIGTNRSvaSEDLGTIAYYFQKNKLDGLIILGGFEGFRS----LKQL 702
Cdd:PTZ00286 123 YGAKYGYKGLYKEDWIK-LDPKDVKTIHRLGGTILGSSRG--GFDPKVMVDTLIRHGINILFTLGGDGTHRGalaiYKEL 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 703 RdgRTQHpifNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLIT 782
Cdd:PTZ00286 200 R--RRKL---NISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVAS 274
|
170 180
....*....|....*....|..
gi 125121 783 GAVSV-YTPEKKIDLASIREDI 803
Cdd:PTZ00286 275 ADVNVcLIPEFDIPLEGVLEYI 296
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
207-479 |
5.01e-10 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 63.23 E-value: 5.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 207 KIAVMTSGGDSPGMNAAVRAVVrTGIHFGCDVFAVYeGYEGLLRG--GKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRK 284
Cdd:PLN02564 89 RACIVTCGGLCPGLNTVIREIV-CGLSYMYGVTRIL-GIDGGYRGfySRNTIPLTPKVVNDIHKRGGTILGTSRGGHDTS 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 285 RegrrqAAGNLISQGIDALVVCGGDGSLTGADLFRHEwpslvdelvAEGRFTKEEVApyknlsivGLVGSIDNDMSGTDS 364
Cdd:PLN02564 167 K-----IVDSIQDRGINQVYIIGGDGTQKGASVIYEE---------IRRRGLKVAVA--------GIPKTIDNDIPVIDK 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 365 TIGAYSALERICEMVDYIDATAKS-HSRAFVVEVMGRHCGWLALMAGIAT-GADYIFIPEraVP---HGKwqDELKEVCQ 439
Cdd:PLN02564 225 SFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPE--SPfylEGK--GGLFEFIE 300
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 125121 440 RhRSKGRRNNTIIVAEGALDDQL-NPVTANDVKDA-----LIELGL 479
Cdd:PLN02564 301 K-RLKENGHMVIVVAEGAGQDLIaESMESSDLQDAsgnklLLDVGL 345
|
|
| Pyrophosphate_PFK |
cd00765 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
201-482 |
5.17e-06 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Pssm-ID: 238390 Cd Length: 550 Bit Score: 50.25 E-value: 5.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 201 SSQKKKKIAVMTSGGDSPGMNAAVRAVVrTGI---HFGCDVFAVYEGYEGLLRgGKYLKKMAwEDVRGWLSEGG-TLIGT 276
Cdd:cd00765 68 SSAPKLKIGIVLSGGQAPGGHNVISGLF-DYLkerAKGSTLYGFKGGPAGILK-CDYIELNA-EYIQPYRNTGGfDMICS 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 277 ARSmEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLfrhewpsLVDELVAEGRFTKeevapyknlsIVGLVGSID 356
Cdd:cd00765 145 GRT-KIETEDQFKQAEETAKKLDLDALVVIGGDDSNTNAAL-------LAENFRSKGLKTR----------VIGVPKTID 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 357 NDM--SGTDSTIGAYSALERICEMVDYIDATAKSHSRAF-VVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKW--- 430
Cdd:cd00765 207 GDLknKEIETSFGFDTATKIYSELIGNVMRDARSTGKYWhFVKLMGRSASHIALECALKTHPNICIISEEVSAQKQTlkn 286
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 125121 431 -QDELKEVCQRHRSKGRRNNTIIVAEG---------ALDDQLNPVTANDVKDaliELGLDTK 482
Cdd:cd00765 287 iTDYMVDVICKRAELGYNFGVVLVPEGliefipevkELIAELNEILANEVVE---FNGLWKK 345
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
173-459 |
5.25e-06 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 50.74 E-value: 5.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 173 AFLEATSEDEIIS-RASSDASdllrqtlgSSQKK---KKIAVMTSGGDSPGMNAAVrAVVRTGIHFgCD----VFAVYEG 244
Cdd:PTZ00468 74 SYFPLTSGNSLVKfEAISDGS--------SSWKKfpaRRIGVVLSGGQASGGHNVI-AGLMSYIKL-CNqssqLFGFLGG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 245 YEGLLrgGKYLKKMAWEDVRGWLSEGG-TLIGTARSMefRKREGRRQAAGNLISQ-GIDALVVCGGDGSLTGAdlfrhew 322
Cdd:PTZ00468 144 PEGVY--SERYRELTEDDINGILNQGGfNIICSGRHK--IETEEQMRASLEICEKlKLHGLVVIGGDDSNTNA------- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 323 pslvdELVAEgRFTKEEvapyKNLSIVGLVGSIDNDMSG--TDSTIGAYSALERICEMVDYI-DATAKSHSRAFVVEVMG 399
Cdd:PTZ00468 213 -----AVLAE-YFKRNS----SSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQIGSImDAIKTEGYGYYFVRLMG 282
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125121 400 RHCGWLALMAGIATGADYIFIPERAVPHGKWQ----DELKEVCQRHRSKGRRNNTIIVAEGALD 459
Cdd:PTZ00468 283 RSASHITLECGLQTRANMILIGEEIKEENRSLmsivDEIVEMILKRDSLGKKHGIVLLPEGLIE 346
|
|
| PRK07085 |
PRK07085 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
201-456 |
1.81e-03 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 235930 Cd Length: 555 Bit Score: 42.22 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 201 SSQKKKKIAVMTSGGDSPG-------MNAAVRAvvrtgIHFGCDVFAVYEGYEGLLRGgKY--LKKMAWEDVRgwlSEGG 271
Cdd:PRK07085 66 SSSKPLKVGVILSGGQAPGghnviagLFDGLKK-----LNPDSKLFGFIGGPLGLLNG-KYieITEEVIDEYR---NTGG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 272 -TLIGTARSmEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGAdlfrhewpslvdELVAEgRFTKEEVapykNLSIVG 350
Cdd:PRK07085 137 fDMIGSGRT-KIETEEQKEACLETVKKLKLDGLVIIGGDDSNTNA------------AILAE-YFAKHGC----KTQVIG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 351 LVGSIDNDMSGT--DSTIGAYSALERICEMVDYI--DA-TAKSHSraFVVEVMGRHCGWLALMAGIATGADYIFIPERAV 425
Cdd:PRK07085 199 VPKTIDGDLKNEfiETSFGFDTATKTYSEMIGNIsrDAlSAKKYW--HFIKLMGRSASHIALECALQTHPNICLISEEVA 276
|
250 260 270
....*....|....*....|....*....|....*.
gi 125121 426 PHGKWQDELKE-----VCQRhRSKGRRNNTIIVAEG 456
Cdd:PRK07085 277 EKKMSLQDIVHyiasvIADR-AAKGKNYGVILIPEG 311
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
719-861 |
3.72e-03 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 41.00 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 719 IPATVSNNVPGTEYSLG--------VDTCLNAlvnYTDdikQSASATRRRVFVCEVQGGHSGYIASFTGLIT-----GAV 785
Cdd:PRK14072 138 IPKTIDNDLPGTDHCPGfgsaakyiATSVLEA---ALD---VAAMANTSKVFILEVMGRHAGWLAAAAALAKqnpddAPH 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125121 786 SVYTPEKKIDLASIREDI-TLLKENFR---------HDKgenrNGKLLVRNEQASSVYS-TQL--LADIISEASKGKFG- 851
Cdd:PRK14072 212 LIYLPERPFDEEKFLADVrAIVKRYGYcvvvvsegiRDA----DGKFIAEAGLAEDAFGhAQLggVAPVLANLIKEKLGk 287
|
170
....*....|.
gi 125121 852 -VRTAIPGHVQ 861
Cdd:PRK14072 288 kVHWAVLDYLQ 298
|
|
| |
