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Conserved domains on  [gi|127116|sp|P21741|]
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RecName: Full=Midkine; Short=MK; AltName: Full=Amphiregulin-associated protein; Short=ARAP; AltName: Full=Midgestation and kidney protein; AltName: Full=Neurite outgrowth-promoting factor 2; AltName: Full=Neurite outgrowth-promoting protein; Flags: Precursor

Protein Classification

PTN domain-containing protein( domain architecture ID 10640840)

PTN domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 37-116 6.50e-46

Pleiotrophin / midkine family; Heparin-binding domain family.


:

Pssm-ID: 128490  Cd Length: 80  Bit Score: 143.87  E-value: 6.50e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127116       37 CAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQC 116
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGTCGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKALYNADC 80
 
Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 37-116 6.50e-46

Pleiotrophin / midkine family; Heparin-binding domain family.


Pssm-ID: 128490  Cd Length: 80  Bit Score: 143.87  E-value: 6.50e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127116       37 CAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQC 116
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGTCGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKALYNADC 80
PTN_MK_N pfam05196
PTN/MK heparin-binding protein family, N-terminal domain;
31-80 4.16e-23

PTN/MK heparin-binding protein family, N-terminal domain;


Pssm-ID: 461582  Cd Length: 57  Bit Score: 85.59  E-value: 4.16e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 127116      31 GGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEF 80
Cdd:pfam05196   8 SKGGSDCAEWQWGKCVPNSGDCGLGFREGTCKEQTKKIKCKIPCNWKKEF 57
 
Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 37-116 6.50e-46

Pleiotrophin / midkine family; Heparin-binding domain family.


Pssm-ID: 128490  Cd Length: 80  Bit Score: 143.87  E-value: 6.50e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127116       37 CAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQC 116
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGTCGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKALYNADC 80
PTN_MK_N pfam05196
PTN/MK heparin-binding protein family, N-terminal domain;
31-80 4.16e-23

PTN/MK heparin-binding protein family, N-terminal domain;


Pssm-ID: 461582  Cd Length: 57  Bit Score: 85.59  E-value: 4.16e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 127116      31 GGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEF 80
Cdd:pfam05196   8 SKGGSDCAEWQWGKCVPNSGDCGLGFREGTCKEQTKKIKCKIPCNWKKEF 57
PTN_MK_C pfam01091
PTN/MK heparin-binding protein family, C-terminal domain;
81-128 1.80e-20

PTN/MK heparin-binding protein family, C-terminal domain;


Pssm-ID: 460059  Cd Length: 65  Bit Score: 79.03  E-value: 1.80e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 127116      81 GADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTP 128
Cdd:pfam01091   1 GADCKYKFGAWGECDPATGTKTRTGTLKKALFNAECQQTVSVTKPCKP 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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