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Conserved domains on  [gi|2507475|sp|P22579|]
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RecName: Full=Transcriptional regulatory protein SIN3

Protein Classification

Sin3 family protein( domain architecture ID 11475663)

Sin3 family protein similar to Saccharomyces cerevisiae paired amphipathic helix protein Sin3, which is the catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4)

CATH:  1.20.1160.11
Gene Ontology:  GO:0003714

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
75-1493 0e+00

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


:

Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 1474.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    75 HAAHILGYPPPHSNAMPSIATDSALKQPHEYHPrpkSSSSSPSINASLMNAgpAPLPTVGAASFslsrfdnplPIKAPVH 154
Cdd:COG5602    1 MDAMNVPVDPPHDNPGDKVMTGSLKQISPKYHP---SMSRDHDVNTSLQNS--EPWPDNGSARK---------PSYSPES 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   155 TEepkSYNGLQEEEKATQRPQDCKEVPAGVQPADAPDPSSNHADANDDNNNNENSHdeDADYRPLNVKDALSYLEQVKFQ 234
Cdd:COG5602   67 MS---SYGGPMDERSGTRRYYEDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPP--RIPYRPLDVSDALSYLEKVKEQ 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   235 FSSRPDIYNLFLDIMKDFKSQAIDTPGVIERVSTLFRGYPILIQGFNTFLPQGYRIECSS-NPD-DPIRVTTPMGTTTVn 312
Cdd:COG5602  142 FSNRPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLpQPNgSRLHVTTPQGPLSS- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   313 nnispsgrgttdaqelgsfpesdgngvqqpsnvPMVPSSVYQSEQNQDQQQSLPLLatssglPSIQQPEMPAHRQIPQsq 392
Cdd:COG5602  221 ---------------------------------PPVQSSYYVAPCNHDQRTSHPTL------PSDSQPEPSAPSHMPS-- 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   393 slvpqeDAKKNVDVEFSQAISYVNKIKTRFADQPDIYKHFLEILQTYQREQKPINEVYAQVTHLFQNAPDLLEDFKKFLP 472
Cdd:COG5602  260 ------DARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDLLEEFKEFLP 333

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   473 DSSASANQQVqhaqqhaqqqheaqmhaqaqaqaqaqaqveqqkqqqqflypasgyyghpSNRGIPQQNLPPIGSFSPPTN 552
Cdd:COG5602  334 DSSVSAEQST-------------------------------------------------ANAQKPSKRLPPIGSFSLPTA 364

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   553 GStvheayqdqqhmqpphFMPLPSIVQHGPNMVHQGIANEnpplSDLRTSLTEQYAPSSIQhqqqhpqsiSPIANTQygd 632
Cdd:COG5602  365 AP----------------EQNRPSLLWESPRSISNISRYR----ADLLTSFSRNFVPIRIH---------MPISHLS--- 412

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   633 ipvrpeidldpsivpvvpeptepiennislNEEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGS 712
Cdd:COG5602  413 ------------------------------NESEDFFERIKQYLKDKNLYHEFLKLLNLYSQKIIDKNDLVERLFAFLGS 462

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   713 NKELFTWFKNFVGYQEKtkciENIVHEKHRLDLDLCEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASED 792
Cdd:COG5602  463 NEELIRWFKAFINYSEP----EKEPLRETRKDLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHPTWASED 538

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   793 SGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETIVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYD 872
Cdd:COG5602  539 SGFIAHRKNQYEEALFKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKVIKKVYD 618

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   873 KERGFEIIDALHEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQLISEI 952
Cdd:COG5602  619 KEHAPEILEALLKKPHVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEI 698

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   953 SsikvDQTNKKIHWLT-PKPKSQLDFDFPDKNIFYDILCLADTFITHTTAYSNPDKERLKDLLKYFISLFFSISFEKIEE 1031
Cdd:COG5602  699 D----DRSQAKIHVSIdDKKVFQFVFVLCDTYIFVNILDLKDTLITNMSSYLESDKERLKANLKTIVSLFFLLCIFRIII 774

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1032 SLYSHKQNVSESSGSDDGSSIASRKRPYQQEMSLLDilhrsryqklkrsndeDGKVPQLSeppeeepnTIEEEELIDEEA 1111
Cdd:COG5602  775 IVYERLLNVKGLNIDGLKADRSSRSDESAQRYSKVK----------------SGNLEQVS--------KQIDEYAIEDEI 830

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1112 KNPWLTGNLVEEANSQGIIQNRSIFNL---FANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRStvtfakdldlls 1188
Cdd:COG5602  831 KEPTHPDGLKEHNISKGISENEKQVIAlteFGNSLMYVFFRLRFDSYERLYEIKKIKEAVTIGMMEPG------------ 898

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1189 sqlsemgldfvgedAYKQVLRLSRRLINGDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMAL 1268
Cdd:COG5602  899 --------------HYENELWDSYRLIFGALTPCEFEKYLRPFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSEL 964

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1269 FVKDRNASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIALDDLTLKEPKADEDKWKYYVTSYALPHPTE 1348
Cdd:COG5602  965 FEMNSAASSKRKQDQTKYRLEVESLLNPDEILFRFCWINKFKSFGIQIMKRADLTVDQSLDTQRVWKYYVQSYAIQHLTE 1044

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1349 GIPHEKLKIPFLERLIEFGQdidgtevdeefspegiSVSTLKIKIQPITYQLHIENGSYDVFTRKATNKYPTIANDNTQK 1428
Cdd:COG5602 1045 GISYKNYKCPFLCRNIEKER----------------TVEQLVSRLQTKLLRSHELVSGLQAFLCLDTFKLLYLPNTEDSY 1108

                       1370      1380      1390      1400      1410      1420
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2507475  1429 GMVSQKKELISKFLDCAvglrnnldeAQKLSMQkKWENLKDSIAKTSAGNQGIESETEKGKITKQ 1493
Cdd:COG5602 1109 IDASYLRLRDSDFLDCQ---------KRKQRWR-NWESLLKSVRKTSANTAEVNFDADINALFIP 1163
 
Name Accession Description Interval E-value
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
75-1493 0e+00

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 1474.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    75 HAAHILGYPPPHSNAMPSIATDSALKQPHEYHPrpkSSSSSPSINASLMNAgpAPLPTVGAASFslsrfdnplPIKAPVH 154
Cdd:COG5602    1 MDAMNVPVDPPHDNPGDKVMTGSLKQISPKYHP---SMSRDHDVNTSLQNS--EPWPDNGSARK---------PSYSPES 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   155 TEepkSYNGLQEEEKATQRPQDCKEVPAGVQPADAPDPSSNHADANDDNNNNENSHdeDADYRPLNVKDALSYLEQVKFQ 234
Cdd:COG5602   67 MS---SYGGPMDERSGTRRYYEDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPP--RIPYRPLDVSDALSYLEKVKEQ 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   235 FSSRPDIYNLFLDIMKDFKSQAIDTPGVIERVSTLFRGYPILIQGFNTFLPQGYRIECSS-NPD-DPIRVTTPMGTTTVn 312
Cdd:COG5602  142 FSNRPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLpQPNgSRLHVTTPQGPLSS- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   313 nnispsgrgttdaqelgsfpesdgngvqqpsnvPMVPSSVYQSEQNQDQQQSLPLLatssglPSIQQPEMPAHRQIPQsq 392
Cdd:COG5602  221 ---------------------------------PPVQSSYYVAPCNHDQRTSHPTL------PSDSQPEPSAPSHMPS-- 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   393 slvpqeDAKKNVDVEFSQAISYVNKIKTRFADQPDIYKHFLEILQTYQREQKPINEVYAQVTHLFQNAPDLLEDFKKFLP 472
Cdd:COG5602  260 ------DARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDLLEEFKEFLP 333

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   473 DSSASANQQVqhaqqhaqqqheaqmhaqaqaqaqaqaqveqqkqqqqflypasgyyghpSNRGIPQQNLPPIGSFSPPTN 552
Cdd:COG5602  334 DSSVSAEQST-------------------------------------------------ANAQKPSKRLPPIGSFSLPTA 364

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   553 GStvheayqdqqhmqpphFMPLPSIVQHGPNMVHQGIANEnpplSDLRTSLTEQYAPSSIQhqqqhpqsiSPIANTQygd 632
Cdd:COG5602  365 AP----------------EQNRPSLLWESPRSISNISRYR----ADLLTSFSRNFVPIRIH---------MPISHLS--- 412

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   633 ipvrpeidldpsivpvvpeptepiennislNEEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGS 712
Cdd:COG5602  413 ------------------------------NESEDFFERIKQYLKDKNLYHEFLKLLNLYSQKIIDKNDLVERLFAFLGS 462

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   713 NKELFTWFKNFVGYQEKtkciENIVHEKHRLDLDLCEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASED 792
Cdd:COG5602  463 NEELIRWFKAFINYSEP----EKEPLRETRKDLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHPTWASED 538

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   793 SGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETIVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYD 872
Cdd:COG5602  539 SGFIAHRKNQYEEALFKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKVIKKVYD 618

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   873 KERGFEIIDALHEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQLISEI 952
Cdd:COG5602  619 KEHAPEILEALLKKPHVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEI 698

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   953 SsikvDQTNKKIHWLT-PKPKSQLDFDFPDKNIFYDILCLADTFITHTTAYSNPDKERLKDLLKYFISLFFSISFEKIEE 1031
Cdd:COG5602  699 D----DRSQAKIHVSIdDKKVFQFVFVLCDTYIFVNILDLKDTLITNMSSYLESDKERLKANLKTIVSLFFLLCIFRIII 774

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1032 SLYSHKQNVSESSGSDDGSSIASRKRPYQQEMSLLDilhrsryqklkrsndeDGKVPQLSeppeeepnTIEEEELIDEEA 1111
Cdd:COG5602  775 IVYERLLNVKGLNIDGLKADRSSRSDESAQRYSKVK----------------SGNLEQVS--------KQIDEYAIEDEI 830

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1112 KNPWLTGNLVEEANSQGIIQNRSIFNL---FANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRStvtfakdldlls 1188
Cdd:COG5602  831 KEPTHPDGLKEHNISKGISENEKQVIAlteFGNSLMYVFFRLRFDSYERLYEIKKIKEAVTIGMMEPG------------ 898

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1189 sqlsemgldfvgedAYKQVLRLSRRLINGDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMAL 1268
Cdd:COG5602  899 --------------HYENELWDSYRLIFGALTPCEFEKYLRPFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSEL 964

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1269 FVKDRNASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIALDDLTLKEPKADEDKWKYYVTSYALPHPTE 1348
Cdd:COG5602  965 FEMNSAASSKRKQDQTKYRLEVESLLNPDEILFRFCWINKFKSFGIQIMKRADLTVDQSLDTQRVWKYYVQSYAIQHLTE 1044

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1349 GIPHEKLKIPFLERLIEFGQdidgtevdeefspegiSVSTLKIKIQPITYQLHIENGSYDVFTRKATNKYPTIANDNTQK 1428
Cdd:COG5602 1045 GISYKNYKCPFLCRNIEKER----------------TVEQLVSRLQTKLLRSHELVSGLQAFLCLDTFKLLYLPNTEDSY 1108

                       1370      1380      1390      1400      1410      1420
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2507475  1429 GMVSQKKELISKFLDCAvglrnnldeAQKLSMQkKWENLKDSIAKTSAGNQGIESETEKGKITKQ 1493
Cdd:COG5602 1109 IDASYLRLRDSDFLDCQ---------KRKQRWR-NWESLLKSVRKTSANTAEVNFDADINALFIP 1163
Sin3a_C pfam16879
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ...
 1138-1410 6.59e-113

C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.


Pssm-ID: 465294  Cd Length: 281  Bit Score: 357.69  E-value: 6.59e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    1138 LFANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRSTVTFAKDLDLLSSQLSEMGLDFV-GEDAYKQVLRLSRRLIN 1216
Cdd:pfam16879    1 FFANTTIYVFFRLFQILYERLLKIKQAEEEVAEEIKRRKANKPAKDLGLISKELEDFGLDLSdPEDYYPQLLELCERLID 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    1217 GDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMALFVKDRNASTTSAKDQIIYRLQVRSHMSN 1296
Cdd:pfam16879   81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYRKQAEKLLGK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    1297 TENMFRIEFDKRTLHVSIQYIALDDLTLKEPKAD-EDKWKYYVTSYALPHPTEGIPHEKLKIPFLERLIEFGQDIDGTEV 1375
Cdd:pfam16879  161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTaEERWQYYVSSYVLSHPTEGVPRSKLRKPFLKRNLKAEREEEEDEE 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 2507475    1376 DEEFSPEG------ISVSTLKIKIQPITYQLHIENGSYDVF 1410
Cdd:pfam16879  241 EEPKADAEepegplEFESGLEIRICLNSYKLFYVPGTEDYF 281
HDAC_interact smart00761
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ...
 748-848 1.75e-55

Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 214808 [Multi-domain]  Cd Length: 102  Bit Score: 187.90  E-value: 1.75e-55
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475      748 CEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRT 827
Cdd:smart00761    2 CERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWASEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSST 81

                            90       100
                    ....*....|....*....|.
gi 2507475      828 IQCLETIVNKIENMTENEKAN 848
Cdd:smart00761   82 IKLLEEILNKIEDMSDEERAN 102
 
Name Accession Description Interval E-value
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
75-1493 0e+00

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 1474.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    75 HAAHILGYPPPHSNAMPSIATDSALKQPHEYHPrpkSSSSSPSINASLMNAgpAPLPTVGAASFslsrfdnplPIKAPVH 154
Cdd:COG5602    1 MDAMNVPVDPPHDNPGDKVMTGSLKQISPKYHP---SMSRDHDVNTSLQNS--EPWPDNGSARK---------PSYSPES 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   155 TEepkSYNGLQEEEKATQRPQDCKEVPAGVQPADAPDPSSNHADANDDNNNNENSHdeDADYRPLNVKDALSYLEQVKFQ 234
Cdd:COG5602   67 MS---SYGGPMDERSGTRRYYEDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPP--RIPYRPLDVSDALSYLEKVKEQ 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   235 FSSRPDIYNLFLDIMKDFKSQAIDTPGVIERVSTLFRGYPILIQGFNTFLPQGYRIECSS-NPD-DPIRVTTPMGTTTVn 312
Cdd:COG5602  142 FSNRPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLpQPNgSRLHVTTPQGPLSS- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   313 nnispsgrgttdaqelgsfpesdgngvqqpsnvPMVPSSVYQSEQNQDQQQSLPLLatssglPSIQQPEMPAHRQIPQsq 392
Cdd:COG5602  221 ---------------------------------PPVQSSYYVAPCNHDQRTSHPTL------PSDSQPEPSAPSHMPS-- 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   393 slvpqeDAKKNVDVEFSQAISYVNKIKTRFADQPDIYKHFLEILQTYQREQKPINEVYAQVTHLFQNAPDLLEDFKKFLP 472
Cdd:COG5602  260 ------DARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDLLEEFKEFLP 333

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   473 DSSASANQQVqhaqqhaqqqheaqmhaqaqaqaqaqaqveqqkqqqqflypasgyyghpSNRGIPQQNLPPIGSFSPPTN 552
Cdd:COG5602  334 DSSVSAEQST-------------------------------------------------ANAQKPSKRLPPIGSFSLPTA 364

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   553 GStvheayqdqqhmqpphFMPLPSIVQHGPNMVHQGIANEnpplSDLRTSLTEQYAPSSIQhqqqhpqsiSPIANTQygd 632
Cdd:COG5602  365 AP----------------EQNRPSLLWESPRSISNISRYR----ADLLTSFSRNFVPIRIH---------MPISHLS--- 412

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   633 ipvrpeidldpsivpvvpeptepiennislNEEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGS 712
Cdd:COG5602  413 ------------------------------NESEDFFERIKQYLKDKNLYHEFLKLLNLYSQKIIDKNDLVERLFAFLGS 462

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   713 NKELFTWFKNFVGYQEKtkciENIVHEKHRLDLDLCEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASED 792
Cdd:COG5602  463 NEELIRWFKAFINYSEP----EKEPLRETRKDLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHPTWASED 538

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   793 SGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETIVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYD 872
Cdd:COG5602  539 SGFIAHRKNQYEEALFKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKVIKKVYD 618

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   873 KERGFEIIDALHEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQLISEI 952
Cdd:COG5602  619 KEHAPEILEALLKKPHVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEI 698

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475   953 SsikvDQTNKKIHWLT-PKPKSQLDFDFPDKNIFYDILCLADTFITHTTAYSNPDKERLKDLLKYFISLFFSISFEKIEE 1031
Cdd:COG5602  699 D----DRSQAKIHVSIdDKKVFQFVFVLCDTYIFVNILDLKDTLITNMSSYLESDKERLKANLKTIVSLFFLLCIFRIII 774

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1032 SLYSHKQNVSESSGSDDGSSIASRKRPYQQEMSLLDilhrsryqklkrsndeDGKVPQLSeppeeepnTIEEEELIDEEA 1111
Cdd:COG5602  775 IVYERLLNVKGLNIDGLKADRSSRSDESAQRYSKVK----------------SGNLEQVS--------KQIDEYAIEDEI 830

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1112 KNPWLTGNLVEEANSQGIIQNRSIFNL---FANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRStvtfakdldlls 1188
Cdd:COG5602  831 KEPTHPDGLKEHNISKGISENEKQVIAlteFGNSLMYVFFRLRFDSYERLYEIKKIKEAVTIGMMEPG------------ 898

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1189 sqlsemgldfvgedAYKQVLRLSRRLINGDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMAL 1268
Cdd:COG5602  899 --------------HYENELWDSYRLIFGALTPCEFEKYLRPFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSEL 964

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1269 FVKDRNASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIALDDLTLKEPKADEDKWKYYVTSYALPHPTE 1348
Cdd:COG5602  965 FEMNSAASSKRKQDQTKYRLEVESLLNPDEILFRFCWINKFKSFGIQIMKRADLTVDQSLDTQRVWKYYVQSYAIQHLTE 1044

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475  1349 GIPHEKLKIPFLERLIEFGQdidgtevdeefspegiSVSTLKIKIQPITYQLHIENGSYDVFTRKATNKYPTIANDNTQK 1428
Cdd:COG5602 1045 GISYKNYKCPFLCRNIEKER----------------TVEQLVSRLQTKLLRSHELVSGLQAFLCLDTFKLLYLPNTEDSY 1108

                       1370      1380      1390      1400      1410      1420
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2507475  1429 GMVSQKKELISKFLDCAvglrnnldeAQKLSMQkKWENLKDSIAKTSAGNQGIESETEKGKITKQ 1493
Cdd:COG5602 1109 IDASYLRLRDSDFLDCQ---------KRKQRWR-NWESLLKSVRKTSANTAEVNFDADINALFIP 1163
Sin3a_C pfam16879
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ...
 1138-1410 6.59e-113

C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.


Pssm-ID: 465294  Cd Length: 281  Bit Score: 357.69  E-value: 6.59e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    1138 LFANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRSTVTFAKDLDLLSSQLSEMGLDFV-GEDAYKQVLRLSRRLIN 1216
Cdd:pfam16879    1 FFANTTIYVFFRLFQILYERLLKIKQAEEEVAEEIKRRKANKPAKDLGLISKELEDFGLDLSdPEDYYPQLLELCERLID 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    1217 GDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMALFVKDRNASTTSAKDQIIYRLQVRSHMSN 1296
Cdd:pfam16879   81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYRKQAEKLLGK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475    1297 TENMFRIEFDKRTLHVSIQYIALDDLTLKEPKAD-EDKWKYYVTSYALPHPTEGIPHEKLKIPFLERLIEFGQDIDGTEV 1375
Cdd:pfam16879  161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTaEERWQYYVSSYVLSHPTEGVPRSKLRKPFLKRNLKAEREEEEDEE 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 2507475    1376 DEEFSPEG------ISVSTLKIKIQPITYQLHIENGSYDVF 1410
Cdd:pfam16879  241 EEPKADAEepegplEFESGLEIRICLNSYKLFYVPGTEDYF 281
Sin3_corepress pfam08295
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms ...
 749-844 4.47e-58

Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 462418  Cd Length: 97  Bit Score: 194.76  E-value: 4.47e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475     749 EAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASEDSG-FIAHRKNQYEETLFKIEEERHEYDFYIESNLRT 827
Cdd:pfam08295    1 KRCGPSYRLLPKSEPQLPCSGRDELCWEVLNDEWVSHPTWASEDSGsFVAHRKNQYEEALFRCEDERYEYDMHIESNLRT 80

                           90
                   ....*....|....*..
gi 2507475     828 IQCLETIVNKIENMTEN 844
Cdd:pfam08295   81 IKLLEPIAEKINNMSPE 97
HDAC_interact smart00761
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ...
 748-848 1.75e-55

Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 214808 [Multi-domain]  Cd Length: 102  Bit Score: 187.90  E-value: 1.75e-55
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507475      748 CEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRT 827
Cdd:smart00761    2 CERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWASEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSST 81

                            90       100
                    ....*....|....*....|.
gi 2507475      828 IQCLETIVNKIENMTENEKAN 848
Cdd:smart00761   82 IKLLEEILNKIEDMSDEERAN 102
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 240-284 1.08e-15

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 72.07  E-value: 1.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2507475     240 DIYNLFLDIMKDFKSQAIDTPGVIERVSTLFRGYPILIQGFNTFL 284
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 427-471 1.39e-15

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 71.68  E-value: 1.39e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2507475     427 DIYKHFLEILQTYQREQKPINEVYAQVTHLFQNAPDLLEDFKKFL 471
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 680-724 8.55e-11

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 58.20  E-value: 8.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2507475     680 HLYTEFLKILNLYSQDILDLDDLVEKVDFYLGSNKELFTWFKNFV 724
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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