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RecName: Full=Prolyl endopeptidase; AltName: Full=Post-proline cleaving enzyme; AltName: Full=Proline-specific endopeptidase; Short=PE; Short=PSE; Flags: Precursor
Protein Classification
prolyl oligopeptidase family serine peptidase ( domain architecture ID 11445431 )
prolyl oligopeptidase family serine peptidase is a S9 family peptidase which catalyzes the cleavage of peptide bonds, specifically the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues
List of domain hits
Name
Accession
Description
Interval
E-value
PreP
COG1505 Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
23-700
0e+00
Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
Pssm-ID: 441114 [Multi-domain]
Cd Length: 673
Bit Score: 1063.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 23 SNV L K YP E T KKVSHT DT yfg T Q V S DPYRWLEDD RAED T K AWV QQEVKF T QD YLA Q IP F R DQ L KKQ L MDIW NY EK I S APFK 102
Cdd:COG1505 1 KKR L T YP A T RRDDVV DT --- T A V A DPYRWLEDD DSPE T L AWV KAQNAV T RA YLA A IP R R EA L RAR L LELL NY DR I P APFK 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 103 K G KYT Y FSK NDGLQ A Q S VL YRK D AA - GKT EV F LDPN KF SE K GT TS L ASV S FNKK G TLV AYS I SEGGSD WNKIIIL D AE T K 181
Cdd:COG1505 78 R G GRY Y NFW NDGLQ N Q G VL RVR D GL d PEW EV L LDPN AL SE D GT WV L GAW S LSPD G RRL AYS L SEGGSD ARVVRVF D VA T G 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 182 KQLDETLLDV K F SG IS WL GDE GF F YS S Y DK P k EGS v L SGMTDKH KVY F H KL GT K QS Q DEL IIG G DKF - P R RY I G AY V TD D 260
Cdd:COG1505 158 EFVEDGFEWE K K SG VA WL DGT GF V YS R Y GE P - EGS - L TDSGYPR KVY Y H RR GT P QS E DEL VFE G PPD d P E RY V G VS V SE D 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 261 Q RYL VV S A A NATNG NELY IK DL KNKT d FI P IITG FD SNVNVADT d G DT LYL F T DK DAP NK RLV KTTIQN P KAET W KDV I A 340
Cdd:COG1505 236 G RYL LI S R A LGFYR NELY LL DL PDGE - LV P LDLP FD ADYSGVVN - G GW LYL L T RL DAP RG RLV AIDLAA P GPRN W TEF I P 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 341 E TSEP LE - INTG GG YFFAT Y MK D AIDQ V KQ YD KN GKLVR AIK LPG S G NA SGF G G EKTEKD L Y YSFT NYI TPPT IFK Y NVT 419
Cdd:COG1505 314 E AEAV LE g VSWT GG RLVLS Y LD D VVSR V RV YD LD GKLVR EVP LPG L G SV SGF S G DDDGDE L F YSFT SFL TPPT LYR Y DLG 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 420 TG N SE VYQ KP KVK F NPEN Y VS EQVF Y TS S DGT KI P MM I SY KKGLK K DG K NPT I LY S YGGFNISL Q P AF S VVNAI W M E N GG 499
Cdd:COG1505 394 TG E SE LLK KP PAP F DASD Y EV EQVF A TS K DGT RV P YF I VH KKGLK L DG P NPT L LY G YGGFNISL T P SY S ASGLA W L E R GG 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 500 I YAV P N I RGGGEYG KK WH D AG T K MQ K K NVF N DFIAA G E Y L QKN GYTS K E YM A LS G R SNGGLLVGA TM T M RP D L AKVAFPG 579
Cdd:COG1505 474 V YAV A N L RGGGEYG PA WH Q AG L K EN K Q NVF D DFIAA A E D L IAR GYTS P E RL A IQ G G SNGGLLVGA AL T Q RP E L FGAVVCA 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 580 V GV LDMLRY N KFTAGA G W AYD YG TAE D s K E M F E YL KS YSP V HNVKAG TC YP S T MVI T S DHDDRV V PAH SF KF GSE LQA K Q 659
Cdd:COG1505 554 V PL LDMLRY H KFTAGA S W IAE YG DPD D - P E E F A YL YA YSP Y HNVKAG VA YP A T LFT T A DHDDRV H PAH AR KF AAR LQA A Q 632
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 130758 660 SCK NP I L I R I ET NA GHGAG RS T E Q VVA E N AD LLS F ALYEM G 700
Cdd:COG1505 633 AGD NP V L Y R E ET EG GHGAG AP T S Q RAE E A AD IYA F LWRNL G 673
Name
Accession
Description
Interval
E-value
PreP
COG1505 Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
23-700
0e+00
Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
Pssm-ID: 441114 [Multi-domain]
Cd Length: 673
Bit Score: 1063.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 23 SNV L K YP E T KKVSHT DT yfg T Q V S DPYRWLEDD RAED T K AWV QQEVKF T QD YLA Q IP F R DQ L KKQ L MDIW NY EK I S APFK 102
Cdd:COG1505 1 KKR L T YP A T RRDDVV DT --- T A V A DPYRWLEDD DSPE T L AWV KAQNAV T RA YLA A IP R R EA L RAR L LELL NY DR I P APFK 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 103 K G KYT Y FSK NDGLQ A Q S VL YRK D AA - GKT EV F LDPN KF SE K GT TS L ASV S FNKK G TLV AYS I SEGGSD WNKIIIL D AE T K 181
Cdd:COG1505 78 R G GRY Y NFW NDGLQ N Q G VL RVR D GL d PEW EV L LDPN AL SE D GT WV L GAW S LSPD G RRL AYS L SEGGSD ARVVRVF D VA T G 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 182 KQLDETLLDV K F SG IS WL GDE GF F YS S Y DK P k EGS v L SGMTDKH KVY F H KL GT K QS Q DEL IIG G DKF - P R RY I G AY V TD D 260
Cdd:COG1505 158 EFVEDGFEWE K K SG VA WL DGT GF V YS R Y GE P - EGS - L TDSGYPR KVY Y H RR GT P QS E DEL VFE G PPD d P E RY V G VS V SE D 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 261 Q RYL VV S A A NATNG NELY IK DL KNKT d FI P IITG FD SNVNVADT d G DT LYL F T DK DAP NK RLV KTTIQN P KAET W KDV I A 340
Cdd:COG1505 236 G RYL LI S R A LGFYR NELY LL DL PDGE - LV P LDLP FD ADYSGVVN - G GW LYL L T RL DAP RG RLV AIDLAA P GPRN W TEF I P 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 341 E TSEP LE - INTG GG YFFAT Y MK D AIDQ V KQ YD KN GKLVR AIK LPG S G NA SGF G G EKTEKD L Y YSFT NYI TPPT IFK Y NVT 419
Cdd:COG1505 314 E AEAV LE g VSWT GG RLVLS Y LD D VVSR V RV YD LD GKLVR EVP LPG L G SV SGF S G DDDGDE L F YSFT SFL TPPT LYR Y DLG 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 420 TG N SE VYQ KP KVK F NPEN Y VS EQVF Y TS S DGT KI P MM I SY KKGLK K DG K NPT I LY S YGGFNISL Q P AF S VVNAI W M E N GG 499
Cdd:COG1505 394 TG E SE LLK KP PAP F DASD Y EV EQVF A TS K DGT RV P YF I VH KKGLK L DG P NPT L LY G YGGFNISL T P SY S ASGLA W L E R GG 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 500 I YAV P N I RGGGEYG KK WH D AG T K MQ K K NVF N DFIAA G E Y L QKN GYTS K E YM A LS G R SNGGLLVGA TM T M RP D L AKVAFPG 579
Cdd:COG1505 474 V YAV A N L RGGGEYG PA WH Q AG L K EN K Q NVF D DFIAA A E D L IAR GYTS P E RL A IQ G G SNGGLLVGA AL T Q RP E L FGAVVCA 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 580 V GV LDMLRY N KFTAGA G W AYD YG TAE D s K E M F E YL KS YSP V HNVKAG TC YP S T MVI T S DHDDRV V PAH SF KF GSE LQA K Q 659
Cdd:COG1505 554 V PL LDMLRY H KFTAGA S W IAE YG DPD D - P E E F A YL YA YSP Y HNVKAG VA YP A T LFT T A DHDDRV H PAH AR KF AAR LQA A Q 632
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 130758 660 SCK NP I L I R I ET NA GHGAG RS T E Q VVA E N AD LLS F ALYEM G 700
Cdd:COG1505 633 AGD NP V L Y R E ET EG GHGAG AP T S Q RAE E A AD IYA F LWRNL G 673
Peptidase_S9_N
pfam02897 Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
28-429
2.51e-179
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.
Pssm-ID: 397164 [Multi-domain]
Cd Length: 414
Bit Score: 517.25
E-value: 2.51e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 28 Y P ETKKVSHT D T Y F G TQ VSDPYRWLEDD RAED T K AWV QQ E V K F T Q D Y LAQ I P - F R DQL K KQ L MDIW NY EK ISAPF K KG K Y 106
Cdd:pfam02897 1 P P TARDEHAV D E Y H G DV VSDPYRWLEDD DSPE T E AWV EA E N K Y T E D F LAQ L P r L R EKI K EE L TALI NY DD ISAPF R KG G Y 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 107 T Y FSK NDG LQA QSVLYR K DA ---- AGKT EVFLDPN KF SE K GT - T S L ASVS F NKK G T L V AYS I S EG GSDW NK I IIL D A ET K 181
Cdd:pfam02897 81 Y Y YFR NDG GKN QSVLYR Q DA lpge GKPE EVFLDPN TL SE D GT f T A L GGFA F SPD G R L L AYS L S LS GSDW YT I RFR D V ET G 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 182 KQ L DET L LD VKFSGI S W LG D - E GFFY SS YDKP K E G S V l S G MTDKH KV YF H K LGT K QSQD E L IIGGD K F P RRYI GA YVTD D 260
Cdd:pfam02897 161 ED L PDV L EG VKFSGI V W AP D g K GFFY TR YDKP D E R S D - T G TNLNQ KV WR H R LGT P QSQD V L VFEFP K D P LWSL GA ERSE D 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 261 QR YL VV S A A NA T NG NELY IK DL KNK T - D FIPIIT G - FD SNVN V ADTD GD TL Y LF T DKD APN K RLV KTTIQN P KAET WKD V 338
Cdd:pfam02897 240 GK YL FI S S A SG T DT NELY YL DL TKE T g D TLKLVD G r FD GEYD V EHNE GD RF Y FL T NDG APN F RLV RVDLND P SPSE WKD L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 339 IA E TSEPL -- EI NTG G G Y FFAT Y MK DA IDQVKQY D - K N GK - L V R AIK LPG S G NA SGF G GE KTEKD L Y YSF TNYI TP P TI F 414
Cdd:pfam02897 320 VP E REDVV le EI TVF G N Y LVLS Y RR DA LSRLQVF D l K T GK v L S R EFP LPG V G SV SGF S GE YDDSE L R YSF SSFL TP G TI Y 399
410
....*....|....*
gi 130758 415 KYNVT TG NS E VYQKP 429
Cdd:pfam02897 400 DLDLA TG EL E LLKFR 414
PRK10115
PRK10115 protease 2; Provisional
29-695
1.69e-61
protease 2; Provisional
Pssm-ID: 182247 [Multi-domain]
Cd Length: 686
Bit Score: 218.22
E-value: 1.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 29 P ETKKVS H TD T YF G TQVS D P Y R WL E DD - R AE - DTKAWVQ QE VKFTQDYL A - Q IPFR D QLK K QLM D IWNYEKI SAP FK K GK 105
Cdd:PRK10115 3 P KAARIP H AM T LH G DTRI D N Y Y WL R DD t R SQ p EVLDYLH QE NSYGHRVM A s Q QALQ D RIL K EII D RIPQREV SAP YI K NG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 106 Y T Y FSKNDG ------ L Q A QS VL yr KDAAGKT E VF LD P NK FSEKGT - TS L ASVSFNKKG T LV A YSISEGGSDWNK I IILDA 178
Cdd:PRK10115 83 Y R Y RHIYEP gceyai Y Q R QS AF -- SEEWDEW E TL LD A NK RAAHSE f YT L GGMAITPDN T IM A LAEDFLSRRQYG I RFRNL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 179 ET KKQLD E T L LD V K f SGIS W LG D EGF FY ss Y DKPKEGSV L S gmtdk HK V YF H KL GT KQ SQDEL IIG g D K FPRR Y IGAYV T 258
Cdd:PRK10115 161 ET GNWYP E L L DN V E - PSFV W AN D SWT FY -- Y VRKHPVTL L P ----- YQ V WR H TI GT PA SQDEL VYE - E K DDTF Y VSLHK T 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 259 DDQR Y L V VSA A N AT NGNE L YIK - D L KNKTD F IPIITGF D SNVNV a D TDGDTL YL FTDKDAP N KR L VK T TIQNPKA et W KD 337
Cdd:PRK10115 232 TSKH Y V V IHL A S AT TSEV L LLD a E L ADAEP F VFLPRRK D HEYSL - D HYQHRF YL RSNRHGK N FG L YR T RVRDEQQ -- W EE 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 338 V I AETSE ple I NTG G GYF F ATYM ----- KDAIDQVK Q YDKNGKL V RA I KL -- P GSGNASGFGG E KTEKD L Y Y SFTNYI TP 410
Cdd:PRK10115 309 L I PPREN --- I MLE G FTL F TDWL vveer QRGLTSLR Q INRKTRE V IG I AF dd P AYVTWIAYNP E PETSR L R Y GYSSMT TP 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 411 P T I F KYNVT TG NSE V YQKPK V K - F NPE NY V SE QVFY T SS DG TKI P MMIS Y KKGLKKD G K NP TIL Y S YG GFNI S LQPA FS V 489
Cdd:PRK10115 386 D T L F ELDMD TG ERR V LKQTE V P g F DAA NY R SE HLWI T AR DG VEV P VSLV Y HRKHFRK G H NP LLV Y G YG SYGA S IDAD FS F 465
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 490 VNAIWMEN G GI YA VPNI RGGGE Y G KK W HDA G TKMQ KKN V FND FIA A GEY L Q K N GY T S KEYMALS G R S N GG L L V G ATMTM R 569
Cdd:PRK10115 466 SRLSLLDR G FV YA IVHV RGGGE L G QQ W YED G KFLK KKN T FND YLD A CDA L L K L GY G S PSLCYGM G G S A GG M L M G VAINQ R 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 570 P D L ----- A K V A F pg V G V LDMLRYNKFTAGA G WAYDY G TAE D s KEMF EY L KSYSP VH NV K A g TC YP STM V I T SD HD DR V V 644
Cdd:PRK10115 546 P E L fhgvi A Q V P F -- V D V VTTMLDESIPLTT G EFEEW G NPQ D - PQYY EY M KSYSP YD NV T A - QA YP HLL V T T GL HD SQ V Q 621
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*
gi 130758 645 PAHSF K FGSE L QAKQSCKNPI L IRIETNA GHG -- A GR -- S T E Q V VA E N A D L LSF A 695
Cdd:PRK10115 622 YWEPA K WVAK L RELKTDDHLL L LCTDMDS GHG gk S GR fk S Y E G V AM E Y A F L IAL A 676
Name
Accession
Description
Interval
E-value
PreP
COG1505 Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
23-700
0e+00
Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
Pssm-ID: 441114 [Multi-domain]
Cd Length: 673
Bit Score: 1063.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 23 SNV L K YP E T KKVSHT DT yfg T Q V S DPYRWLEDD RAED T K AWV QQEVKF T QD YLA Q IP F R DQ L KKQ L MDIW NY EK I S APFK 102
Cdd:COG1505 1 KKR L T YP A T RRDDVV DT --- T A V A DPYRWLEDD DSPE T L AWV KAQNAV T RA YLA A IP R R EA L RAR L LELL NY DR I P APFK 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 103 K G KYT Y FSK NDGLQ A Q S VL YRK D AA - GKT EV F LDPN KF SE K GT TS L ASV S FNKK G TLV AYS I SEGGSD WNKIIIL D AE T K 181
Cdd:COG1505 78 R G GRY Y NFW NDGLQ N Q G VL RVR D GL d PEW EV L LDPN AL SE D GT WV L GAW S LSPD G RRL AYS L SEGGSD ARVVRVF D VA T G 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 182 KQLDETLLDV K F SG IS WL GDE GF F YS S Y DK P k EGS v L SGMTDKH KVY F H KL GT K QS Q DEL IIG G DKF - P R RY I G AY V TD D 260
Cdd:COG1505 158 EFVEDGFEWE K K SG VA WL DGT GF V YS R Y GE P - EGS - L TDSGYPR KVY Y H RR GT P QS E DEL VFE G PPD d P E RY V G VS V SE D 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 261 Q RYL VV S A A NATNG NELY IK DL KNKT d FI P IITG FD SNVNVADT d G DT LYL F T DK DAP NK RLV KTTIQN P KAET W KDV I A 340
Cdd:COG1505 236 G RYL LI S R A LGFYR NELY LL DL PDGE - LV P LDLP FD ADYSGVVN - G GW LYL L T RL DAP RG RLV AIDLAA P GPRN W TEF I P 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 341 E TSEP LE - INTG GG YFFAT Y MK D AIDQ V KQ YD KN GKLVR AIK LPG S G NA SGF G G EKTEKD L Y YSFT NYI TPPT IFK Y NVT 419
Cdd:COG1505 314 E AEAV LE g VSWT GG RLVLS Y LD D VVSR V RV YD LD GKLVR EVP LPG L G SV SGF S G DDDGDE L F YSFT SFL TPPT LYR Y DLG 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 420 TG N SE VYQ KP KVK F NPEN Y VS EQVF Y TS S DGT KI P MM I SY KKGLK K DG K NPT I LY S YGGFNISL Q P AF S VVNAI W M E N GG 499
Cdd:COG1505 394 TG E SE LLK KP PAP F DASD Y EV EQVF A TS K DGT RV P YF I VH KKGLK L DG P NPT L LY G YGGFNISL T P SY S ASGLA W L E R GG 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 500 I YAV P N I RGGGEYG KK WH D AG T K MQ K K NVF N DFIAA G E Y L QKN GYTS K E YM A LS G R SNGGLLVGA TM T M RP D L AKVAFPG 579
Cdd:COG1505 474 V YAV A N L RGGGEYG PA WH Q AG L K EN K Q NVF D DFIAA A E D L IAR GYTS P E RL A IQ G G SNGGLLVGA AL T Q RP E L FGAVVCA 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 580 V GV LDMLRY N KFTAGA G W AYD YG TAE D s K E M F E YL KS YSP V HNVKAG TC YP S T MVI T S DHDDRV V PAH SF KF GSE LQA K Q 659
Cdd:COG1505 554 V PL LDMLRY H KFTAGA S W IAE YG DPD D - P E E F A YL YA YSP Y HNVKAG VA YP A T LFT T A DHDDRV H PAH AR KF AAR LQA A Q 632
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 130758 660 SCK NP I L I R I ET NA GHGAG RS T E Q VVA E N AD LLS F ALYEM G 700
Cdd:COG1505 633 AGD NP V L Y R E ET EG GHGAG AP T S Q RAE E A AD IYA F LWRNL G 673
Peptidase_S9_N
pfam02897 Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
28-429
2.51e-179
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.
Pssm-ID: 397164 [Multi-domain]
Cd Length: 414
Bit Score: 517.25
E-value: 2.51e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 28 Y P ETKKVSHT D T Y F G TQ VSDPYRWLEDD RAED T K AWV QQ E V K F T Q D Y LAQ I P - F R DQL K KQ L MDIW NY EK ISAPF K KG K Y 106
Cdd:pfam02897 1 P P TARDEHAV D E Y H G DV VSDPYRWLEDD DSPE T E AWV EA E N K Y T E D F LAQ L P r L R EKI K EE L TALI NY DD ISAPF R KG G Y 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 107 T Y FSK NDG LQA QSVLYR K DA ---- AGKT EVFLDPN KF SE K GT - T S L ASVS F NKK G T L V AYS I S EG GSDW NK I IIL D A ET K 181
Cdd:pfam02897 81 Y Y YFR NDG GKN QSVLYR Q DA lpge GKPE EVFLDPN TL SE D GT f T A L GGFA F SPD G R L L AYS L S LS GSDW YT I RFR D V ET G 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 182 KQ L DET L LD VKFSGI S W LG D - E GFFY SS YDKP K E G S V l S G MTDKH KV YF H K LGT K QSQD E L IIGGD K F P RRYI GA YVTD D 260
Cdd:pfam02897 161 ED L PDV L EG VKFSGI V W AP D g K GFFY TR YDKP D E R S D - T G TNLNQ KV WR H R LGT P QSQD V L VFEFP K D P LWSL GA ERSE D 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 261 QR YL VV S A A NA T NG NELY IK DL KNK T - D FIPIIT G - FD SNVN V ADTD GD TL Y LF T DKD APN K RLV KTTIQN P KAET WKD V 338
Cdd:pfam02897 240 GK YL FI S S A SG T DT NELY YL DL TKE T g D TLKLVD G r FD GEYD V EHNE GD RF Y FL T NDG APN F RLV RVDLND P SPSE WKD L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 339 IA E TSEPL -- EI NTG G G Y FFAT Y MK DA IDQVKQY D - K N GK - L V R AIK LPG S G NA SGF G GE KTEKD L Y YSF TNYI TP P TI F 414
Cdd:pfam02897 320 VP E REDVV le EI TVF G N Y LVLS Y RR DA LSRLQVF D l K T GK v L S R EFP LPG V G SV SGF S GE YDDSE L R YSF SSFL TP G TI Y 399
410
....*....|....*
gi 130758 415 KYNVT TG NS E VYQKP 429
Cdd:pfam02897 400 DLDLA TG EL E LLKFR 414
PtrB
COG1770 Protease II [Amino acid transport and metabolism];
22-702
2.68e-125
Protease II [Amino acid transport and metabolism];
Pssm-ID: 441376 [Multi-domain]
Cd Length: 686
Bit Score: 387.89
E-value: 2.68e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 22 NSNVLKY P ET KK VS HT D T YF G TQVS D P Y R WL E D DRAEDTK A WVQQ E VKF T QDYL A - QI P FRDQ L kkqlmdiwn YEKI --- 97
Cdd:COG1770 5 AAAAPTP P VA KK RP HT R T HH G DTRV D D Y A WL R D REDPEVL A YLEA E NAY T EAVM A p TK P LQET L --------- FAEM kgr 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 98 ------ S A P FKK G K Y T Y F S KNDGLQAQSVLY RK - DAAGKT EV F LD P N KFS E - KGTT SL ASV S FNKK G T L V AYS ISEG GS D 169
Cdd:COG1770 76 ikedds S V P YRD G G Y W Y Y S RTEEGKQYPIYC RK p ASGAGE EV L LD G N ALA E g HDFF SL GGL S VSPD G R L L AYS VDTV GS E 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 170 WNKII I L D A ET KKQ L DETLLDV k FS G IS W LG D - EGF FY SSY D K --- P kegsvlsgmtdk HK V YF H K LGT KQSQ D E L I igg 245
Cdd:COG1770 156 RYTLR I K D L ET GED L PDVIENT - SG G LV W AA D n RTL FY TRV D E tlr P ------------ YQ V WR H R LGT DPAE D V L V --- 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 246 dk F ---- P R RYI G AYV T DDQ RY L V VSAANA T N g N E LYIK D LKNK T D ---- FI P IIT G FDSN V nva DTD GD TL Y LF T DK DA 317
Cdd:COG1770 220 -- Y eekd E R FFV G VGK T RSG RY I V IGSGST T T - S E VRLL D ADDP T A eprl VA P REE G VEYS V --- EHA GD RF Y IL T ND DA 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 318 PN KR LV KTTIQN P KA E T W KDV I A - ETSEP LE intg G GYF F ATYM ----- KDAIDQVKQY D KNGKLVRA I KLPGSGNAS G F 391
Cdd:COG1770 294 PN FK LV RAPVDA P SR E N W QEL I P h RPGVL LE ---- G VDA F KDHL vvser ENGLPRIRVR D LDDGEEHE I AFDEEAYTA G L 369
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 392 GG -- E KTEKD L Y YS FTNYI TP PTIFK Y NVT TG NSEVYQKPK V -- K F N P EN YVSE QVFY T SS DGTK I P MMIS Y K K GL K K DG 467
Cdd:COG1770 370 GG np E FDTDT L R YS YSSLT TP SSVYD Y DLA TG ERTLLKQQE V pg G F D P AD YVSE RLWA T AR DGTK V P VSLV Y R K DT K L DG 449
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 468 KN P TI LY S YG GFN IS LQ P A FS VVNAIWMEN G GI YA VPN IRGGGE Y G KK W HDA G TKMQ KKN V F N DFIA AG E Y L QKN GYTS K 547
Cdd:COG1770 450 SA P LL LY G YG SYG IS ID P S FS TSRLSLLDR G FV YA IAH IRGGGE L G RR W YED G KLLK KKN T F T DFIA CA E H L IAQ GYTS P 529
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 548 EYMALS G R S N GGLL V GA TMT M R P D L ----- A K V A F pg V G VL D - ML rynkftagagway D ------------ Y G TAEDS KE 609
Cdd:COG1770 530 GRIVAM G G S A GGLL M GA VAN M A P E L fagvi A Q V P F -- V D VL T t ML ------------- D pslplttgewde W G NPLND KE 594
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 610 MFE Y L KSYSP VH NVKA GT c YP STM V I T SDH D D RV V --- PA hsf K FGSE L QAKQSCK NP I L IRIETN AGHG -- A GR S te QV 684
Cdd:COG1770 595 AYD Y M KSYSP YD NVKA QA - YP AIL V T T GLN D S RV Q ywe PA --- K WVAK L RELKTDD NP L L LKTNMD AGHG ga S GR F -- DA 668
730
....*....|....*...
gi 130758 685 VA E N A DLLS F A L YEM GI K 702
Cdd:COG1770 669 LK E V A LEYA F L L DLL GI A 686
Peptidase_S9
pfam00326 Prolyl oligopeptidase family;
485-701
2.96e-66
Prolyl oligopeptidase family;
Pssm-ID: 459761 [Multi-domain]
Cd Length: 213
Bit Score: 217.48
E-value: 2.96e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 485 P A FS VVNAIWMEN G GIY A VP N I RG G G E YG KKW HDAG TKMQKK N V F N DFIAA G EYL QKN GYT SKEYM A LS G R S N GG L L V GA 564
Cdd:pfam00326 1 P S FS WNAQLLADR G YVV A IA N G RG S G G YG EAF HDAG KGDLGQ N E F D DFIAA A EYL IEQ GYT DPDRL A IW G G S Y GG Y L T GA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 565 TMTM RPDL A K V A FPG V G V L D M L R Y NKF T AG -- AGWAYDY G TAE D SK E MFE YL KS YSP VH NVK A gtc YP STMV I TSDH DDR 642
Cdd:pfam00326 81 ALNQ RPDL F K A A VAH V P V V D W L A Y MSD T SL pf TERYMEW G NPW D NE E GYD YL SP YSP AD NVK V --- YP PLLL I HGLL DDR 157
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 130758 643 V V P AH S F K FGSE LQ A K Q sck N P I L IR I ETNA GHG A G RSTEQ v V A E N A DL L S F A L YEM G I 701
Cdd:pfam00326 158 V P P WQ S L K LVAA LQ R K G --- V P F L LL I FPDE GHG I G KPRNK - V E E Y A RE L A F L L EYL G G 212
PRK10115
PRK10115 protease 2; Provisional
29-695
1.69e-61
protease 2; Provisional
Pssm-ID: 182247 [Multi-domain]
Cd Length: 686
Bit Score: 218.22
E-value: 1.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 29 P ETKKVS H TD T YF G TQVS D P Y R WL E DD - R AE - DTKAWVQ QE VKFTQDYL A - Q IPFR D QLK K QLM D IWNYEKI SAP FK K GK 105
Cdd:PRK10115 3 P KAARIP H AM T LH G DTRI D N Y Y WL R DD t R SQ p EVLDYLH QE NSYGHRVM A s Q QALQ D RIL K EII D RIPQREV SAP YI K NG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 106 Y T Y FSKNDG ------ L Q A QS VL yr KDAAGKT E VF LD P NK FSEKGT - TS L ASVSFNKKG T LV A YSISEGGSDWNK I IILDA 178
Cdd:PRK10115 83 Y R Y RHIYEP gceyai Y Q R QS AF -- SEEWDEW E TL LD A NK RAAHSE f YT L GGMAITPDN T IM A LAEDFLSRRQYG I RFRNL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 179 ET KKQLD E T L LD V K f SGIS W LG D EGF FY ss Y DKPKEGSV L S gmtdk HK V YF H KL GT KQ SQDEL IIG g D K FPRR Y IGAYV T 258
Cdd:PRK10115 161 ET GNWYP E L L DN V E - PSFV W AN D SWT FY -- Y VRKHPVTL L P ----- YQ V WR H TI GT PA SQDEL VYE - E K DDTF Y VSLHK T 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 259 DDQR Y L V VSA A N AT NGNE L YIK - D L KNKTD F IPIITGF D SNVNV a D TDGDTL YL FTDKDAP N KR L VK T TIQNPKA et W KD 337
Cdd:PRK10115 232 TSKH Y V V IHL A S AT TSEV L LLD a E L ADAEP F VFLPRRK D HEYSL - D HYQHRF YL RSNRHGK N FG L YR T RVRDEQQ -- W EE 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 338 V I AETSE ple I NTG G GYF F ATYM ----- KDAIDQVK Q YDKNGKL V RA I KL -- P GSGNASGFGG E KTEKD L Y Y SFTNYI TP 410
Cdd:PRK10115 309 L I PPREN --- I MLE G FTL F TDWL vveer QRGLTSLR Q INRKTRE V IG I AF dd P AYVTWIAYNP E PETSR L R Y GYSSMT TP 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 411 P T I F KYNVT TG NSE V YQKPK V K - F NPE NY V SE QVFY T SS DG TKI P MMIS Y KKGLKKD G K NP TIL Y S YG GFNI S LQPA FS V 489
Cdd:PRK10115 386 D T L F ELDMD TG ERR V LKQTE V P g F DAA NY R SE HLWI T AR DG VEV P VSLV Y HRKHFRK G H NP LLV Y G YG SYGA S IDAD FS F 465
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 490 VNAIWMEN G GI YA VPNI RGGGE Y G KK W HDA G TKMQ KKN V FND FIA A GEY L Q K N GY T S KEYMALS G R S N GG L L V G ATMTM R 569
Cdd:PRK10115 466 SRLSLLDR G FV YA IVHV RGGGE L G QQ W YED G KFLK KKN T FND YLD A CDA L L K L GY G S PSLCYGM G G S A GG M L M G VAINQ R 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 570 P D L ----- A K V A F pg V G V LDMLRYNKFTAGA G WAYDY G TAE D s KEMF EY L KSYSP VH NV K A g TC YP STM V I T SD HD DR V V 644
Cdd:PRK10115 546 P E L fhgvi A Q V P F -- V D V VTTMLDESIPLTT G EFEEW G NPQ D - PQYY EY M KSYSP YD NV T A - QA YP HLL V T T GL HD SQ V Q 621
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*
gi 130758 645 PAHSF K FGSE L QAKQSCKNPI L IRIETNA GHG -- A GR -- S T E Q V VA E N A D L LSF A 695
Cdd:PRK10115 622 YWEPA K WVAK L RELKTDDHLL L LCTDMDS GHG gk S GR fk S Y E G V AM E Y A F L IAL A 676
DAP2
COG1506 Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
445-680
7.17e-26
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
Pssm-ID: 441115 [Multi-domain]
Cd Length: 234
Bit Score: 106.64
E-value: 7.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 445 YT S S DGT KI P MMISYKKG lkk DG K N P TIL Y SY GG FN i S LQPA F SVVNAIWMEN G gi YAV -- P NI RG gge YG KKWH D A G TK 522
Cdd:COG1506 2 FK S A DGT TL P GWLYLPAD --- GK K Y P VVV Y VH GG PG - S RDDS F LPLAQALASR G -- YAV la P DY RG --- YG ESAG D W G GD 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 523 MQ kknvf N D FI AA GE YL QKNG Y TSKEYMALS G R S N GG LLVGATMTMR PD LA K V A FPGV GV L D MLR Y NKF T agag WA Y DYG 602
Cdd:COG1506 73 EV ----- D D VL AA ID YL AARP Y VDPDRIGIY G H S Y GG YMALLAAARH PD RF K A A VALA GV S D LRS Y YGT T ---- RE Y TER 143
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 130758 603 TAEDSK E MF E YLKSY SP VHNVKAGTC y P s TMV I TSDH DDRV V P AHSFKFGSE L QAKQ sc K NPI L IRIE t NA GHG AGRS 680
Cdd:COG1506 144 LMGGPW E DP E AYAAR SP LAYADKLKT - P - LLL I HGEA DDRV P P EQAERLYEA L KKAG -- K PVE L LVYP - GE GHG FSGA 216
DLH
COG0412 Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
439-586
1.34e-03
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440181 [Multi-domain]
Cd Length: 226
Bit Score: 40.72
E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 439 VS E Q V FYTSS DG TKI P MMISYKK G lkk D G KN P TIL ysyggfnislqpafsvvna IWM E NG G I --------------- Y A V 503
Cdd:COG0412 2 TT E T V TIPTP DG VTL P GYLARPA G --- G G PR P GVV ------------------- VLH E IF G L nphirdvarrlaaag Y V V 59
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 504 -- P NIR G G G EY G KKWHD A GTK M QKKN --- VFN D FI AA GEY L QKNGYTSKEYMALS G RSN GG L L VGATMTMR PDL - A K V A F 577
Cdd:COG0412 60 la P DLY G R G GP G DDPDE A RAL M GALD pel LAA D LR AA LDW L KAQPEVDAGRVGVV G FCF GG G L ALLAAARG PDL a A A V S F 139
....*....
gi 130758 578 P G VGVL D M L 586
Cdd:COG0412 140 Y G GLPA D D L 148
FrsA
COG1073 Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
441-675
1.99e-03
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];
Pssm-ID: 440691 [Multi-domain]
Cd Length: 253
Bit Score: 40.67
E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 441 E Q V FYT S S DG T K IPMMISYKK G LK K dg K N P TILYSY G - G FNIS lqpa FSVVN A IWM - E N G gi YA V -- PNI RG G GE YGKKW 516
Cdd:COG1073 11 E D V TFK S R DG I K LAGDLYLPA G AS K -- K Y P AVVVAH G n G GVKE ---- QRALY A QRL a E L G -- FN V la FDY RG Y GE SEGEP 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 517 HDA G TKMQ kknvf N D FI AA GE YL QKNGYTSK E YMA L S G R S N GG LLVGATMTMR P DLAK V AF -- P GVGVL D MLRY - N K FTA 593
Cdd:COG1073 83 REE G SPER ----- R D AR AA VD YL RTLPGVDP E RIG L L G I S L GG GYALNAAATD P RVKA V IL ds P FTSLE D LAAQ r A K EAR 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130758 594 GA GW - AYD Y GTAEDSKEMFE yl KSYS P VHNVKAGTC y P s TMV I TSDH D D rvvp A HS F KFGSE L QAK qs CKN P I - L IRIE t 671
Cdd:COG1073 158 GA YL p GVP Y LPNVRLASLLN -- DEFD P LAKIEKISR - P - LLF I HGEK D E ---- A VP F YMSED L YEA -- AAE P K e L LIVP - 226
....
gi 130758 672 N AGH 675
Cdd:COG1073 227 G AGH 230
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
