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Conserved domains on  [gi|112851|sp|P27682|]
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RecName: Full=Neuroendocrine protein 7B2; AltName: Full=Secretogranin V; AltName: Full=Secretogranin-5; AltName: Full=Secretory granule endocrine protein I; Contains: RecName: Full=N-terminal peptide; Contains: RecName: Full=C-terminal peptide; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Secretogranin_V super family cl05037
Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a ...
 22-197 1.99e-13

Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.


The actual alignment was detected with superfamily member pfam05281:

Pssm-ID: 368368  Cd Length: 230  Bit Score: 66.46  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112851      22 AFAYSPRTPDRVSETDIQRLLHG---VMEQLGIARPRV---EYPAHQAmnLVGPQSIEGGAHEGLQHLGPfgnipnIVAe 95
Cdd:pfam05281  27 AAAAAKDNVDLVSRSEYARLCDGgsdCLLQSNNPNPSLrdqEFLQHSS--LWGHQFVSGGMGEGPNRYKT------IVK- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112851      96 lTGDNIPkdfsedqGYPDPPNPCPLG---KTADDGCLENAPDTAEFSREFQLDQ-------HLFD-PEHDYPGLGKWNKK 164
Cdd:pfam05281  98 -TDASLP-------AYCNPPNPCPEGydvETQGGGCIMDFENTAIFSREFQAAQdctcdseHMFDcSQENAADVGEGDGD 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 112851     165 L--LYEKMKGGQ----------------------RRKRRSVNPYLQGKRLDnVVAKK 197
Cdd:pfam05281 170 LdsAVEQFILHQfgnenslnnhnnlvkkaghmpdPRIKAVINPFLQGDRLP-IAAKK 225
 
Name Accession Description Interval E-value
Secretogranin_V pfam05281
Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a ...
 22-197 1.99e-13

Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.


Pssm-ID: 368368  Cd Length: 230  Bit Score: 66.46  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112851      22 AFAYSPRTPDRVSETDIQRLLHG---VMEQLGIARPRV---EYPAHQAmnLVGPQSIEGGAHEGLQHLGPfgnipnIVAe 95
Cdd:pfam05281  27 AAAAAKDNVDLVSRSEYARLCDGgsdCLLQSNNPNPSLrdqEFLQHSS--LWGHQFVSGGMGEGPNRYKT------IVK- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112851      96 lTGDNIPkdfsedqGYPDPPNPCPLG---KTADDGCLENAPDTAEFSREFQLDQ-------HLFD-PEHDYPGLGKWNKK 164
Cdd:pfam05281  98 -TDASLP-------AYCNPPNPCPEGydvETQGGGCIMDFENTAIFSREFQAAQdctcdseHMFDcSQENAADVGEGDGD 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 112851     165 L--LYEKMKGGQ----------------------RRKRRSVNPYLQGKRLDnVVAKK 197
Cdd:pfam05281 170 LdsAVEQFILHQfgnenslnnhnnlvkkaghmpdPRIKAVINPFLQGDRLP-IAAKK 225
 
Name Accession Description Interval E-value
Secretogranin_V pfam05281
Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a ...
 22-197 1.99e-13

Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.


Pssm-ID: 368368  Cd Length: 230  Bit Score: 66.46  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112851      22 AFAYSPRTPDRVSETDIQRLLHG---VMEQLGIARPRV---EYPAHQAmnLVGPQSIEGGAHEGLQHLGPfgnipnIVAe 95
Cdd:pfam05281  27 AAAAAKDNVDLVSRSEYARLCDGgsdCLLQSNNPNPSLrdqEFLQHSS--LWGHQFVSGGMGEGPNRYKT------IVK- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112851      96 lTGDNIPkdfsedqGYPDPPNPCPLG---KTADDGCLENAPDTAEFSREFQLDQ-------HLFD-PEHDYPGLGKWNKK 164
Cdd:pfam05281  98 -TDASLP-------AYCNPPNPCPEGydvETQGGGCIMDFENTAIFSREFQAAQdctcdseHMFDcSQENAADVGEGDGD 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 112851     165 L--LYEKMKGGQ----------------------RRKRRSVNPYLQGKRLDnVVAKK 197
Cdd:pfam05281 170 LdsAVEQFILHQfgnenslnnhnnlvkkaghmpdPRIKAVINPFLQGDRLP-IAAKK 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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