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Conserved domains on  [gi|1722806|sp|P29788|]
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RecName: Full=Vitronectin; Short=VN; AltName: Full=S-protein; AltName: Full=Serum-spreading factor; Flags: Precursor

Protein Classification

Somatomedin_B and HX domain-containing protein( domain architecture ID 10470560)

Somatomedin_B and HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 153-473 2.33e-45

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 156.70  E-value: 2.33e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  153 ELCSGKPFDAFTDLkNGSLFAFRGQYCYELDETaVRPGYPKLIQDVW-GIEGPIDAAFTRINcQGKTYLFKGSQYWRFED 231
Cdd:cd00094   2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPG-KPPGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  232 GVLDPGYPRNISE-GFSGIPDNVDAAFalpahRYSGRERVYFFKGKQYWEYEFQQQPSQEECegsslsavfehfallqrd 310
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAAL-----RWPDNGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  311 swenifellfwgrssdgarePQFISRNWHGVPGKVDAAMAgriyvtgslshsaqakkqkskrrsrkryrsrrgrghrrsq 390
Cdd:cd00094 136 --------------------PKLIETDFPGVPDKVDAAFR---------------------------------------- 155

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  391 ssnsrrssrsiwfslfsseesglgtynnydydmdWLVPATcepiqsvYFFSGDKYYRVNLRTRRVDsvnPPYPRSIAQYW 470
Cdd:cd00094 156 ----------------------------------WLDGYY-------YFFKGDQYWRFDPRSKEVR---VGYPLKISSDW 191


                ...
gi 1722806  471 LGC 473
Cdd:cd00094 192 LGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
22-61 3.31e-14

Somatomedin B domain;


:

Pssm-ID: 460034  Cd Length: 40  Bit Score: 66.56  E-value: 3.31e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1722806     22 ESCKGRCTQGFMASKKCQCDELCTYYQSCCADYMEQCKPQ 61
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 153-473 2.33e-45

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 156.70  E-value: 2.33e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  153 ELCSGKPFDAFTDLkNGSLFAFRGQYCYELDETaVRPGYPKLIQDVW-GIEGPIDAAFTRINcQGKTYLFKGSQYWRFED 231
Cdd:cd00094   2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPG-KPPGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  232 GVLDPGYPRNISE-GFSGIPDNVDAAFalpahRYSGRERVYFFKGKQYWEYEFQQQPSQEECegsslsavfehfallqrd 310
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAAL-----RWPDNGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  311 swenifellfwgrssdgarePQFISRNWHGVPGKVDAAMAgriyvtgslshsaqakkqkskrrsrkryrsrrgrghrrsq 390
Cdd:cd00094 136 --------------------PKLIETDFPGVPDKVDAAFR---------------------------------------- 155

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  391 ssnsrrssrsiwfslfsseesglgtynnydydmdWLVPATcepiqsvYFFSGDKYYRVNLRTRRVDsvnPPYPRSIAQYW 470
Cdd:cd00094 156 ----------------------------------WLDGYY-------YFFKGDQYWRFDPRSKEVR---VGYPLKISSDW 191


                ...
gi 1722806  471 LGC 473
Cdd:cd00094 192 LGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
22-61 3.31e-14

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 66.56  E-value: 3.31e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1722806     22 ESCKGRCTQGFMASKKCQCDELCTYYQSCCADYMEQCKPQ 61
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 20-62 1.59e-13

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 64.70  E-value: 1.59e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1722806      20 DQESCKGRCTQGFMASKKCQCDELCTYYQSCCADYMEQCKPQV 62
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 205-250 2.35e-12

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 61.10  E-value: 2.35e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1722806     205 IDAAFTRINcqGKTYLFKGSQYWRFEDGVLDPGYPRNISEGFSGIP 250
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 205-250 1.56e-10

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 56.04  E-value: 1.56e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1722806    205 IDAAFTRINcqGKTYLFKGSQYWRFEDGVLDPGYPRNISEgFSGIP 250
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLP 43
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 153-473 2.33e-45

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 156.70  E-value: 2.33e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  153 ELCSGKPFDAFTDLkNGSLFAFRGQYCYELDETaVRPGYPKLIQDVW-GIEGPIDAAFTRINcQGKTYLFKGSQYWRFED 231
Cdd:cd00094   2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPG-KPPGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  232 GVLDPGYPRNISE-GFSGIPDNVDAAFalpahRYSGRERVYFFKGKQYWEYEFQQQPSQEECegsslsavfehfallqrd 310
Cdd:cd00094  79 KNLEPGYPKPISDlGFPPTVKQIDAAL-----RWPDNGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  311 swenifellfwgrssdgarePQFISRNWHGVPGKVDAAMAgriyvtgslshsaqakkqkskrrsrkryrsrrgrghrrsq 390
Cdd:cd00094 136 --------------------PKLIETDFPGVPDKVDAAFR---------------------------------------- 155

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1722806  391 ssnsrrssrsiwfslfsseesglgtynnydydmdWLVPATcepiqsvYFFSGDKYYRVNLRTRRVDsvnPPYPRSIAQYW 470
Cdd:cd00094 156 ----------------------------------WLDGYY-------YFFKGDQYWRFDPRSKEVR---VGYPLKISSDW 191


                ...
gi 1722806  471 LGC 473
Cdd:cd00094 192 LGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
22-61 3.31e-14

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 66.56  E-value: 3.31e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1722806     22 ESCKGRCTQGFMASKKCQCDELCTYYQSCCADYMEQCKPQ 61
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 20-62 1.59e-13

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 64.70  E-value: 1.59e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1722806      20 DQESCKGRCTQGFMASKKCQCDELCTYYQSCCADYMEQCKPQV 62
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 205-250 2.35e-12

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 61.10  E-value: 2.35e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1722806     205 IDAAFTRINcqGKTYLFKGSQYWRFEDGVLDPGYPRNISEGFSGIP 250
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 205-250 1.56e-10

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 56.04  E-value: 1.56e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1722806    205 IDAAFTRINcqGKTYLFKGSQYWRFEDGVLDPGYPRNISEgFSGIP 250
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 160-199 1.36e-07

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 47.62  E-value: 1.36e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1722806     160 FDAFTDLKNGSLFAFRGQYCYELDETAVRPGYPKLIQDVW 199
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFF 40
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 160-202 7.86e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 45.64  E-value: 7.86e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1722806    160 FDAFTDLKNGSLFAFRGQYCYELDETAVRPGYPKLIQDVWGIE 202
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISDFPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 429-472 1.71e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.84  E-value: 1.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1722806     429 ATCEPIQSVYFFSGDKYYRVNlrtrrVDSVNPPYPRSIAQYWLG 472
Cdd:smart00120   4 AFELRDGKTYFFKGDKYWRFD-----PKRVDPGYPKLISSFFPG 42
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 429-473 3.91e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 40.63  E-value: 3.91e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1722806    429 ATCEPIQSVYFFSGDKYYRVNLRTrrvdsVNPPYPRSIAQY-WLGC 473
Cdd:pfam00045   4 AFEDRDGKTYFFKGRKYWRFDPQR-----VEPGYPKLISDFpGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-285 3.95e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 37.99  E-value: 3.95e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1722806     253 VDAAFalpahrYSGRERVYFFKGKQYWEYEFQQ 285
Cdd:smart00120   1 IDAAF------ELRDGKTYFFKGDKYWRFDPKR 27
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-287 2.04e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 2.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1722806    253 VDAAFalpahrYSGRERVYFFKGKQYWEYEFQQQP 287
Cdd:pfam00045   1 IDAAF------EDRDGKTYFFKGRKYWRFDPQRVE 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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