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Conserved domains on  [gi|322510142|sp|P33151|]
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RecName: Full=Cadherin-5; AltName: Full=7B4 antigen; AltName: Full=Vascular endothelial cadherin; Short=VE-cadherin; AltName: CD_antigen=CD144; Flags: Precursor

Protein Classification

Cadherin_repeat and Cadherin_C domain-containing protein( domain architecture ID 11254411)

Cadherin_repeat and Cadherin_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 3.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGrIITITKSLDREKQARYEIVVEARDa 232
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTG-EITTAKPLDREEQSSYTLTVTATD- 76

                         90       100
                 ....*....|....*....|..
gi 322510142 233 QGLRGDSGTATVLVTLQDINDN 254
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 716-775 6.56e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.99  E-value: 6.56e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  716 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
263-364 2.28e-24

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 2.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  263 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDP 342
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 322510142  343 TidlrymSPPAGNRAQVIINIT 364
Cdd:pfam00028  77 G------GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-475 1.90e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 377 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 453
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                         90       100
                 ....*....|....*....|..
gi 322510142 454 GTPtGKESIVQVHIEVLDENDN 475
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 482-576 5.15e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 482 PYQPKVCENAVHGQLVLQISAIDKDItPRNVKFKFIL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 558
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*...
gi 322510142 559 DNGMPSRTGTSTLTVAVC 576
Cdd:cd11304   76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-149 1.75e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.75e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 322510142    79 NAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 149
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 3.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGrIITITKSLDREKQARYEIVVEARDa 232
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTG-EITTAKPLDREEQSSYTLTVTATD- 76

                         90       100
                 ....*....|....*....|..
gi 322510142 233 QGLRGDSGTATVLVTLQDINDN 254
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 716-775 6.56e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.99  E-value: 6.56e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  716 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
263-364 2.28e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 2.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  263 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDP 342
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 322510142  343 TidlrymSPPAGNRAQVIINIT 364
Cdd:pfam00028  77 G------GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 263-368 2.28e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 2.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 263 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETnpahNEGIIKPMKPLDYEYIQQYSFIVEATDP 342
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDP----STGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*.
gi 322510142 343 TidlrymSPPAGNRAQVIINITDVDE 368
Cdd:cd11304   78 G------GPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
156-249 3.22e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.59  E-value: 3.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKGKEY--FAIDNSGRIITITKSLDREKQARYEIVVEARDaQ 233
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATD-S 76

                          90
                  ....*....|....*.
gi 322510142  234 GLRGDSGTATVLVTLQ 249
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 174-256 1.62e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.62e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   174 TAVDADDptvGDHASVMYQILKG--KEYFAIDNSGRIITITKSLDREKQARYEIVVEARDaQGLRGDSGTATVLVTLQDI 251
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDV 76


                   ....*
gi 322510142   252 NDNFP 256
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-475 1.90e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 377 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 453
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                         90       100
                 ....*....|....*....|..
gi 322510142 454 GTPtGKESIVQVHIEVLDENDN 475
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
377-470 6.72e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 6.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  377 YHFQLKENQK-KPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDstg 454
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--- 77

                          90
                  ....*....|....*.
gi 322510142  455 tPTGKESIVQVHIEVL 470
Cdd:pfam00028  78 -GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 482-576 5.15e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 482 PYQPKVCENAVHGQLVLQISAIDKDItPRNVKFKFIL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 558
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*...
gi 322510142 559 DNGMPSRTGTSTLTVAVC 576
Cdd:cd11304   76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 282-370 1.07e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   282 VEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDPTidlrymSPPAGNRAQVII 361
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTATVTI 71

                           90
                   ....*....|
gi 322510142   362 NITDV-DEPP 370
Cdd:smart00112  72 TVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-149 1.75e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.75e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 322510142    79 NAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 149
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 395-477 3.93e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 3.93e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   395 AMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKelDSTGTPtgKESIVQVHIEVLDEN 473
Cdd:smart00112   2 ATDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT--DGGGPP--LSSTATVTITVLDVN 77


                   ....
gi 322510142   474 DNAP 477
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
53-142 3.00e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   53 QMHIDEEKNT-SLPHHVGKI-KSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGEN 130
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATdPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GPP 80

                          90
                  ....*....|..
gi 322510142  131 LETPSSFTIKVH 142
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
487-576 3.25e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  487 VCENAVHGQLVLQISAIDKDITPRNVKFKFIL--NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVISDNGMPS 564
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRI---DPDTGDISTT-KPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 322510142  565 RTGTSTLTVAVC 576
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-147 4.51e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 4.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  53 QMHIDEekNTSLPHHVGKIKS----SVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtG 128
Cdd:cd11304    3 EVSVPE--NAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                         90
                 ....*....|....*....
gi 322510142 129 ENLETPSSFTIKVHDVNDN 147
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 501-580 4.34e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 4.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   501 SAIDKDiTPRNVKFKFILNTENNFTLTDNHDNTANITVKyGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 580
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 3.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGrIITITKSLDREKQARYEIVVEARDa 232
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTG-EITTAKPLDREEQSSYTLTVTATD- 76

                         90       100
                 ....*....|....*....|..
gi 322510142 233 QGLRGDSGTATVLVTLQDINDN 254
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 716-775 6.56e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.99  E-value: 6.56e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  716 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
263-364 2.28e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 2.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  263 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDP 342
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 322510142  343 TidlrymSPPAGNRAQVIINIT 364
Cdd:pfam00028  77 G------GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 263-368 2.28e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 2.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 263 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETnpahNEGIIKPMKPLDYEYIQQYSFIVEATDP 342
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDP----STGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*.
gi 322510142 343 TidlrymSPPAGNRAQVIINITDVDE 368
Cdd:cd11304   78 G------GPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
156-249 3.22e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.59  E-value: 3.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKGKEY--FAIDNSGRIITITKSLDREKQARYEIVVEARDaQ 233
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATD-S 76

                          90
                  ....*....|....*.
gi 322510142  234 GLRGDSGTATVLVTLQ 249
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 174-256 1.62e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.62e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   174 TAVDADDptvGDHASVMYQILKG--KEYFAIDNSGRIITITKSLDREKQARYEIVVEARDaQGLRGDSGTATVLVTLQDI 251
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDV 76


                   ....*
gi 322510142   252 NDNFP 256
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-475 1.90e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 377 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 453
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                         90       100
                 ....*....|....*....|..
gi 322510142 454 GTPtGKESIVQVHIEVLDENDN 475
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
377-470 6.72e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 6.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  377 YHFQLKENQK-KPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDstg 454
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--- 77

                          90
                  ....*....|....*.
gi 322510142  455 tPTGKESIVQVHIEVL 470
Cdd:pfam00028  78 -GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 482-576 5.15e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142 482 PYQPKVCENAVHGQLVLQISAIDKDItPRNVKFKFIL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 558
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*...
gi 322510142 559 DNGMPSRTGTSTLTVAVC 576
Cdd:cd11304   76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 282-370 1.07e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   282 VEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDPTidlrymSPPAGNRAQVII 361
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTATVTI 71

                           90
                   ....*....|
gi 322510142   362 NITDV-DEPP 370
Cdd:smart00112  72 TVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-149 1.75e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.75e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 322510142    79 NAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 149
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 395-477 3.93e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 3.93e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   395 AMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKelDSTGTPtgKESIVQVHIEVLDEN 473
Cdd:smart00112   2 ATDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT--DGGGPP--LSSTATVTITVLDVN 77


                   ....
gi 322510142   474 DNAP 477
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
53-142 3.00e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   53 QMHIDEEKNT-SLPHHVGKI-KSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGEN 130
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATdPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GPP 80

                          90
                  ....*....|..
gi 322510142  131 LETPSSFTIKVH 142
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
487-576 3.25e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  487 VCENAVHGQLVLQISAIDKDITPRNVKFKFIL--NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVISDNGMPS 564
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRI---DPDTGDISTT-KPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 322510142  565 RTGTSTLTVAVC 576
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-147 4.51e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 4.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  53 QMHIDEekNTSLPHHVGKIKS----SVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtG 128
Cdd:cd11304    3 EVSVPE--NAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                         90
                 ....*....|....*....
gi 322510142 129 ENLETPSSFTIKVHDVNDN 147
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 501-580 4.34e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 4.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142   501 SAIDKDiTPRNVKFKFILNTENNFTLTDNHDNTANITVKyGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 580
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 61-147 1.54e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.95  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322510142  61 NTSLPHHVGKIKSSV---SRKNAKYLLKG-EYVGKVFRVDAETGDVFAIERLDRENISEYHLTaVIVDKDTGENLETPSS 136
Cdd:cd00031    9 GRSRGSFRVSIPTDLiasSGEIIKISAAGkEALPSWLHWEPHSGILEGLEKLDREDKGVHYIS-VSAASLGANVPQTSSV 87

                         90
                 ....*....|.
gi 322510142 137 FTIKVHDVNDN 147
Cdd:cd00031   88 FSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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