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Conserved domains on  [gi|586456|sp|P38169|]
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RecName: Full=Kynurenine 3-monooxygenase; AltName: Full=Biosynthesis of nicotinic acid protein 4; AltName: Full=Kynurenine 3-hydroxylase

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11428987)

FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0071949|GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-398 5.15e-39

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 143.54  E-value: 5.15e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYD----FRQDPRldttknknlksiNLAISARGIDALKSIdpDACEHILQD 76
Cdd:COG0654   2 MRTDVLIVGGGPAGLALALALARAGIRVTVVErappPRPDGR------------GIALSPRSLELLRRL--GLWDRLLAR 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    77 MIPMKGRMIHD-LKGRQESQL-YGLHG-EAINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAIGEdl 153
Cdd:COG0654  68 GAPIRGIRVRDgSDGRVLARFdAAETGlPAGLVVPRADLERALLEAARALGVELRFGTEVTGLEQDADGVTVTLADGR-- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   154 ktphTEKYDFVIGCDGAYSATRSQmqrkvemdfsqeymnlryieLYIPPTEEfkpNYGGNFAIApdhlhiwprhkfmlia 233
Cdd:COG0654 146 ----TLRADLVVGADGARSAVRRL--------------------LGIGFTGR---DYPQRALWA---------------- 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   234 lansdgsftstffgskdqisDLITsksRVREFLIENFPDIINIMDLDDAVkrfiTYPkesLVCVNCKPYdvPGGKAILLG 313
Cdd:COG0654 183 --------------------GVRT---ELRARLAAAGPRLGELLELSPRS----AFP---LRRRRAERW--RRGRVVLLG 230

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   314 DAAHAMVPFYGQGMNCGFEDVRILMALLKKH--SGDRSRAFTEYTQTRHKDLVSITELAKRNYKEMSHDVTSKRFLLRKK 391
Cdd:COG0654 231 DAAHTMHPLGGQGANLALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALGRLFHPDSPPLRLLRNAG 310


                ....*..
gi 586456   392 LDALFSI 398
Cdd:COG0654 311 LRLLDRL 317
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-398 5.15e-39

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 143.54  E-value: 5.15e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYD----FRQDPRldttknknlksiNLAISARGIDALKSIdpDACEHILQD 76
Cdd:COG0654   2 MRTDVLIVGGGPAGLALALALARAGIRVTVVErappPRPDGR------------GIALSPRSLELLRRL--GLWDRLLAR 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    77 MIPMKGRMIHD-LKGRQESQL-YGLHG-EAINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAIGEdl 153
Cdd:COG0654  68 GAPIRGIRVRDgSDGRVLARFdAAETGlPAGLVVPRADLERALLEAARALGVELRFGTEVTGLEQDADGVTVTLADGR-- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   154 ktphTEKYDFVIGCDGAYSATRSQmqrkvemdfsqeymnlryieLYIPPTEEfkpNYGGNFAIApdhlhiwprhkfmlia 233
Cdd:COG0654 146 ----TLRADLVVGADGARSAVRRL--------------------LGIGFTGR---DYPQRALWA---------------- 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   234 lansdgsftstffgskdqisDLITsksRVREFLIENFPDIINIMDLDDAVkrfiTYPkesLVCVNCKPYdvPGGKAILLG 313
Cdd:COG0654 183 --------------------GVRT---ELRARLAAAGPRLGELLELSPRS----AFP---LRRRRAERW--RRGRVVLLG 230

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   314 DAAHAMVPFYGQGMNCGFEDVRILMALLKKH--SGDRSRAFTEYTQTRHKDLVSITELAKRNYKEMSHDVTSKRFLLRKK 391
Cdd:COG0654 231 DAAHTMHPLGGQGANLALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALGRLFHPDSPPLRLLRNAG 310


                ....*..
gi 586456   392 LDALFSI 398
Cdd:COG0654 311 LRLLDRL 317
PRK06753 PRK06753
hypothetical protein; Provisional
 5-361 1.90e-21

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 95.53  E-value: 1.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      5 VAIIGAGLVGCLAALAFSKEGYNVTLYDfrqdprldttKNKNLKSIN--LAISARGIDALKSIDpdacehILQDMIPMKG 82
Cdd:PRK06753   3 IAIIGAGIGGLTAAALLQEQGHEVKVFE----------KNESVKEVGagIGIGDNVIKKLGNHD------LAKGIKNAGQ 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     83 RMIH----DLKGRQESQLYGLHGEAINSINRSVLNNSLLDELEKSTTELkfGHKLVKIEWTDDKQICHFAIGEdlktphT 158
Cdd:PRK06753  67 ILSTmnllDDKGTLLNKVKLKSNTLNVTLHRQTLIDIIKSYVKEDAIFT--GKEVTKIENETDKVTIHFADGE------S 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    159 EKYDFVIGCDGAYSATRSQMQRKVEMDFsQEYMNLR----YIELYIPPTeeFKPNYG--GNFAIAP--DHLHIWprhkFM 230
Cdd:PRK06753 139 EAFDLCIGADGIHSKVRQSVNADSKVRY-QGYTCFRglidDIDLKLPDC--AKEYWGtkGRFGIVPllNNQAYW----FI 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    231 LIALANSDGSFTStfFGSKDQISDLITSKSRVREFLiEN-------FPDIINIMDLDDAVKrfitypkeslvcvnckpyd 303
Cdd:PRK06753 212 TINAKERDPKYSS--FGKPHLQAYFNHYPNEVREIL-DKqsetgilHHDIYDLKPLKSFVY------------------- 269

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 586456    304 vpgGKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHsgDRSRAFTEYTQTRHK 361
Cdd:PRK06753 270 ---GRIVLLGDAAHATTPNMGQGAGQAMEDAIVLANCLNAY--DFEKALQRYDKIRVK 322
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 5-369 1.28e-16

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 81.10  E-value: 1.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456       5 VAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLksiNLAISARGIDALKSIDpdACEHILQDMI-PMKGr 83
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKVALIEATPLPAPADPGFDNR---VSALSAASIRLLEKLG--VWDKIEPARAqPIRD- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      84 mIHDLKGRQESQL----YGLHGEAINSI--NRsVLNNSLLDEL-EKSTTELKFGHKLVKIEWTDDKQICHFAIGEDLKTp 156
Cdd:TIGR01988  76 -IHVSDGGSFGALrfdaDEIGLEALGYVveNR-VLQQALWERLqELPNVTLLCPARVVELPRHSDHVELTLDDGQQLRA- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     157 htekyDFVIGCDGAYSATRSQMQRKVEM-DFSQeYMNLRYIELYIPP----TEEFKPNygGNFAIAP--DHLH--IW--- 224
Cdd:TIGR01988 153 -----RLLVGADGANSKVRQLAGIPTTGwDYGQ-SAVVANVKHERPHqgtaWERFTPT--GPLALLPlpDNRSslVWtlp 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     225 PRHKFMLIALanSDGSFTSTF---FGSkdQISDLITSKSRVReflienFPDIINImdlddaVKRFItypKESLVcvnckp 301
Cdd:TIGR01988 225 PEEAERLLAL--SDEEFLAELqraFGS--RLGAITLVGERHA------FPLSLTH------AKRYV---APRLA------ 279

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 586456     302 ydvpggkaiLLGDAAHAMVPFYGQGMNCGFEDVRIL-MALLKKHS-----GDrSRAFTEYTQTRHKDLVSITEL 369
Cdd:TIGR01988 280 ---------LIGDAAHTIHPLAGQGLNLGLRDVAALaEVLEDARRrgediGS-LRVLQRYERRRRFDNAAMLGA 343
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 5-348 1.24e-09

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 59.65  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456       5 VAIIGAGLVGCLAALAFSKEGYNVTLYD----FRQDPRLDTTknkNLKSINLaISARGIDAlkSIDPDACEHILQDMIPM 80
Cdd:pfam01494   4 VLIVGGGPAGLMLALLLARAGVRVVLVErhatTSVLPRAHGL---NQRTMEL-LRQAGLED--RILAEGVPHEGMGLAFY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      81 KGRMIHDLKGRQEsqlyglhGEAINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKqICHFAIGEDLKTPHTEK 160
Cdd:pfam01494  78 NTRRRADLDFLTS-------PPRVTVYPQTELEPILVEHAEARGAQVRFGTEVLSLEQDGDG-VTAVVRDRRDGEEYTVR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     161 YDFVIGCDGAYSATRSQM--QRKVEMDFSQEYMNlryIELYIPPTEEFKPNYGGNFAIAPDHlhiwPRhKFMLIALAN-- 236
Cdd:pfam01494 150 AKYLVGCDGGRSPVRKTLgiEFEGFEGVPFGSLD---VLFDAPDLSDPVERAFVHYLIYAPH----SR-GFMVGPWRSag 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     237 -SDGSFTSTFFGSKDQISDLITsksrvREFLIENFPDIINIMDLDDAVKRFITYPKESLVCvncKPYDVpgGKAILLGDA 315
Cdd:pfam01494 222 rERYYVQVPWDEEVEERPEEFT-----DEELKQRLRSIVGIDLALVEILWKSIWGVASRVA---TRYRK--GRVFLAGDA 291

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 586456     316 AHAMVPFYGQGMNCGFEDVR----ILMALLKKHSGDR 348
Cdd:pfam01494 292 AHIHPPTGGQGLNTAIQDAFnlawKLAAVLRGQAGES 328
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-398 5.15e-39

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 143.54  E-value: 5.15e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYD----FRQDPRldttknknlksiNLAISARGIDALKSIdpDACEHILQD 76
Cdd:COG0654   2 MRTDVLIVGGGPAGLALALALARAGIRVTVVErappPRPDGR------------GIALSPRSLELLRRL--GLWDRLLAR 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    77 MIPMKGRMIHD-LKGRQESQL-YGLHG-EAINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAIGEdl 153
Cdd:COG0654  68 GAPIRGIRVRDgSDGRVLARFdAAETGlPAGLVVPRADLERALLEAARALGVELRFGTEVTGLEQDADGVTVTLADGR-- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   154 ktphTEKYDFVIGCDGAYSATRSQmqrkvemdfsqeymnlryieLYIPPTEEfkpNYGGNFAIApdhlhiwprhkfmlia 233
Cdd:COG0654 146 ----TLRADLVVGADGARSAVRRL--------------------LGIGFTGR---DYPQRALWA---------------- 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   234 lansdgsftstffgskdqisDLITsksRVREFLIENFPDIINIMDLDDAVkrfiTYPkesLVCVNCKPYdvPGGKAILLG 313
Cdd:COG0654 183 --------------------GVRT---ELRARLAAAGPRLGELLELSPRS----AFP---LRRRRAERW--RRGRVVLLG 230

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456   314 DAAHAMVPFYGQGMNCGFEDVRILMALLKKH--SGDRSRAFTEYTQTRHKDLVSITELAKRNYKEMSHDVTSKRFLLRKK 391
Cdd:COG0654 231 DAAHTMHPLGGQGANLALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALGRLFHPDSPPLRLLRNAG 310


                ....*..
gi 586456   392 LDALFSI 398
Cdd:COG0654 311 LRLLDRL 317
PRK06753 PRK06753
hypothetical protein; Provisional
 5-361 1.90e-21

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 95.53  E-value: 1.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      5 VAIIGAGLVGCLAALAFSKEGYNVTLYDfrqdprldttKNKNLKSIN--LAISARGIDALKSIDpdacehILQDMIPMKG 82
Cdd:PRK06753   3 IAIIGAGIGGLTAAALLQEQGHEVKVFE----------KNESVKEVGagIGIGDNVIKKLGNHD------LAKGIKNAGQ 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     83 RMIH----DLKGRQESQLYGLHGEAINSINRSVLNNSLLDELEKSTTELkfGHKLVKIEWTDDKQICHFAIGEdlktphT 158
Cdd:PRK06753  67 ILSTmnllDDKGTLLNKVKLKSNTLNVTLHRQTLIDIIKSYVKEDAIFT--GKEVTKIENETDKVTIHFADGE------S 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    159 EKYDFVIGCDGAYSATRSQMQRKVEMDFsQEYMNLR----YIELYIPPTeeFKPNYG--GNFAIAP--DHLHIWprhkFM 230
Cdd:PRK06753 139 EAFDLCIGADGIHSKVRQSVNADSKVRY-QGYTCFRglidDIDLKLPDC--AKEYWGtkGRFGIVPllNNQAYW----FI 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    231 LIALANSDGSFTStfFGSKDQISDLITSKSRVREFLiEN-------FPDIINIMDLDDAVKrfitypkeslvcvnckpyd 303
Cdd:PRK06753 212 TINAKERDPKYSS--FGKPHLQAYFNHYPNEVREIL-DKqsetgilHHDIYDLKPLKSFVY------------------- 269

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 586456    304 vpgGKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHsgDRSRAFTEYTQTRHK 361
Cdd:PRK06753 270 ---GRIVLLGDAAHATTPNMGQGAGQAMEDAIVLANCLNAY--DFEKALQRYDKIRVK 322
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 5-369 1.28e-16

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 81.10  E-value: 1.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456       5 VAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLksiNLAISARGIDALKSIDpdACEHILQDMI-PMKGr 83
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKVALIEATPLPAPADPGFDNR---VSALSAASIRLLEKLG--VWDKIEPARAqPIRD- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      84 mIHDLKGRQESQL----YGLHGEAINSI--NRsVLNNSLLDEL-EKSTTELKFGHKLVKIEWTDDKQICHFAIGEDLKTp 156
Cdd:TIGR01988  76 -IHVSDGGSFGALrfdaDEIGLEALGYVveNR-VLQQALWERLqELPNVTLLCPARVVELPRHSDHVELTLDDGQQLRA- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     157 htekyDFVIGCDGAYSATRSQMQRKVEM-DFSQeYMNLRYIELYIPP----TEEFKPNygGNFAIAP--DHLH--IW--- 224
Cdd:TIGR01988 153 -----RLLVGADGANSKVRQLAGIPTTGwDYGQ-SAVVANVKHERPHqgtaWERFTPT--GPLALLPlpDNRSslVWtlp 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     225 PRHKFMLIALanSDGSFTSTF---FGSkdQISDLITSKSRVReflienFPDIINImdlddaVKRFItypKESLVcvnckp 301
Cdd:TIGR01988 225 PEEAERLLAL--SDEEFLAELqraFGS--RLGAITLVGERHA------FPLSLTH------AKRYV---APRLA------ 279

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 586456     302 ydvpggkaiLLGDAAHAMVPFYGQGMNCGFEDVRIL-MALLKKHS-----GDrSRAFTEYTQTRHKDLVSITEL 369
Cdd:TIGR01988 280 ---------LIGDAAHTIHPLAGQGLNLGLRDVAALaEVLEDARRrgediGS-LRVLQRYERRRRFDNAAMLGA 343
PRK06847 PRK06847
hypothetical protein; Provisional
 5-360 4.57e-15

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 76.45  E-value: 4.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      5 VAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTknknlkSINLaiSARGIDALKSID--PDACEHILqdmiPMKG 82
Cdd:PRK06847   7 VLIVGGGIGGLSAAIALRRAGIAVDLVEIDPEWRVYGA------GITL--QGNALRALRELGvlDECLEAGF----GFDG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     83 RMIHDLKGRQESQLYG--LHGE---AINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAIGEdlktph 157
Cdd:PRK06847  75 VDLFDPDGTLLAELPTprLAGDdlpGGGGIMRPALARILADAARAAGADVRLGTTVTAIEQDDDGVTVTFSDGT------ 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    158 TEKYDFVIGCDGAYSATRSQMQRKvemDFSQEYMNL---RYielYIPPTEEFkpnyggnfaiapDHLHIW--PRHKFMLI 232
Cdd:PRK06847 149 TGRYDLVVGADGLYSKVRSLVFPD---EPEPEYTGQgvwRA---VLPRPAEV------------DRSLMYlgPTTKAGVV 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    233 ALansdgsftstffgSKDQISDLITSKSRVREF------------LIENFPDIINimdldDAVKRFITYPKEslvcVNCK 300
Cdd:PRK06847 211 PL-------------SEDLMYLFVTEPRPDNPRiepdtlaallreLLAPFGGPVL-----QELREQITDDAQ----VVYR 268

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586456    301 PYD---VPG----GKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHsGDRSRAFTEYTQTRH 360
Cdd:PRK06847 269 PLEtllVPApwhrGRVVLIGDAAHATTPHLAQGAGMAIEDAIVLAEELARH-DSLEAALQAYYARRW 334
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 5-387 7.60e-13

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 69.80  E-value: 7.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      5 VAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLKSInlAISARGIDALKSIDpdACEHILQDMI-PMKgr 83
Cdd:PRK08849   6 IAVVGGGMVGAATALGFAKQGRSVAVIEGGEPKAFEPSQPMDIRVS--AISQTSVDLLESLG--AWSSIVAMRVcPYK-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     84 mihdlkgRQESQLyglHGEAINSINRSVLNnslLDEL----EKSTTELKFGH--------------KLVKIEWTDDKQIC 145
Cdd:PRK08849  80 -------RLETWE---HPECRTRFHSDELN---LDQLgyivENRLIQLGLWQqfaqypnltlmcpeKLADLEFSAEGNRV 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    146 HFAIGEDLKTphtekyDFVIGCDGAYSATRSQMQRKVEM-DFSQEYMnLRYIELYIPPTE----EFKPNyggnfaiapdh 220
Cdd:PRK08849 147 TLESGAEIEA------KWVIGADGANSQVRQLAGIGITAwDYRQHCM-LINVETEQPQQDitwqQFTPS----------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    221 lhiWPRHkfmLIALANSDGSFTstFFGSKDQISDLIT-SKSRVREFLIENFPDIINimdlDDAVKRFITYP-----KESL 294
Cdd:PRK08849 209 ---GPRS---FLPLCGNQGSLV--WYDSPKRIKQLSAmNPEQLRSEILRHFPAELG----EIKVLQHGSFPltrrhAQQY 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    295 VCVNCkpydvpggkaILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDRSRAFTEYTQTRHKDLVSITELAKRNY 374
Cdd:PRK08849 277 VKNNC----------VLLGDAAHTINPLAGQGVNLGFKDVDVLLAETEKQGVLNDASFARYERRRRPDNLLMQTGMDLFY 346

                        410
                 ....*....|...
gi 586456    375 KEMSHDVTSKRFL 387
Cdd:PRK08849 347 KTFSNSLTPLKFV 359
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
10-210 2.14e-10

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 61.14  E-value: 2.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    10 AGLVGCLAALAFSKEGYNVTLYDFRQDPRldttkNKNLKSinlAISARGIDALKSIDPDacEHILQdmiPMKGRMIHDLK 89
Cdd:COG0644   1 AGPAGSAAARRLARAGLSVLLLEKGSFPG-----DKICGG---GLLPRALEELEPLGLD--EPLER---PVRGARFYSPG 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    90 GRQESQLYGLHGEAInsINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAIGEDLktphteKYDFVIGCDG 169
Cdd:COG0644  68 GKSVELPPGRGGGYV--VDRARFDRWLAEQAEEAGAEVRTGTRVTDVLRDDGRVVVRTGDGEEI------RADYVVDADG 139

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 586456   170 AYSATRSQMQRKVEMDFSQEYMNLRYIELYIPPTEEFKPNY 210
Cdd:COG0644 140 ARSLLARKLGLKRRSDEPQDYALAIKEHWELPPLEGVDPGA 180
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 5-348 1.24e-09

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 59.65  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456       5 VAIIGAGLVGCLAALAFSKEGYNVTLYD----FRQDPRLDTTknkNLKSINLaISARGIDAlkSIDPDACEHILQDMIPM 80
Cdd:pfam01494   4 VLIVGGGPAGLMLALLLARAGVRVVLVErhatTSVLPRAHGL---NQRTMEL-LRQAGLED--RILAEGVPHEGMGLAFY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      81 KGRMIHDLKGRQEsqlyglhGEAINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKqICHFAIGEDLKTPHTEK 160
Cdd:pfam01494  78 NTRRRADLDFLTS-------PPRVTVYPQTELEPILVEHAEARGAQVRFGTEVLSLEQDGDG-VTAVVRDRRDGEEYTVR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     161 YDFVIGCDGAYSATRSQM--QRKVEMDFSQEYMNlryIELYIPPTEEFKPNYGGNFAIAPDHlhiwPRhKFMLIALAN-- 236
Cdd:pfam01494 150 AKYLVGCDGGRSPVRKTLgiEFEGFEGVPFGSLD---VLFDAPDLSDPVERAFVHYLIYAPH----SR-GFMVGPWRSag 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     237 -SDGSFTSTFFGSKDQISDLITsksrvREFLIENFPDIINIMDLDDAVKRFITYPKESLVCvncKPYDVpgGKAILLGDA 315
Cdd:pfam01494 222 rERYYVQVPWDEEVEERPEEFT-----DEELKQRLRSIVGIDLALVEILWKSIWGVASRVA---TRYRK--GRVFLAGDA 291

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 586456     316 AHAMVPFYGQGMNCGFEDVR----ILMALLKKHSGDR 348
Cdd:pfam01494 292 AHIHPPTGGQGLNTAIQDAFnlawKLAAVLRGQAGES 328
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 5-343 1.98e-09

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 59.39  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456       5 VAIIGAGLVGclAALAFSKeGYNVTLYDFRQDpRLDTTKNKNLKSINL------------AISARGIDALKSIDpdACEH 72
Cdd:TIGR01989   3 VVIVGGGPVG--LALAAAL-GNNPLTKDLKVL-LLDAVDNPKLKSRNYekpdgpysnrvsSITPASISFFKKIG--AWDH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      73 ILQDMIPMKGRM----------IH-DLKGRQESQLYglhgeainSINRSVLNNSLLDELEKSTT---ELKFGHKLVKIEW 138
Cdd:TIGR01989  77 IQSDRIQPFGRMqvwdgcslalIRfDRDNGKEDMAC--------IIENDNIQNSLYNRLQEYNGdnvKILNPARLISVTI 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     139 TddkqicHFAIGEDLKTPHTE-------KYDFVIGCDGAYSATRSQMQRKVemdFSQEY--------MNLRYIELYIPPT 203
Cdd:TIGR01989 149 P------SKYPNDNSNWVHITlsdgqvlYTKLLIGADGSNSNVRKAANIDT---TGWNYnqhavvatLKLEEATENDVAW 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     204 EEFKPNygGNFAIAP--DHLH--IW---PRHKFMLIALANSD--GSFTSTF---FGSKDQISDLITSKSRVREFL----- 266
Cdd:TIGR01989 220 QRFLPT--GPIALLPlpDNNStlVWstsPEEALRLLSLPPEDfvDALNAAFdlgYSDHPYSYLLDYAMEKLNEDIgfrte 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     267 --IENF---PDIINIMDlddavKRFITYPkesLVCVNCKPYDVPGgkAILLGDAAHAMVPFYGQGMNCGFEDVRILMALL 341
Cdd:TIGR01989 298 gsKSCFqvpPRVIGVVD-----KSRAAFP---LGLGHADEYVTKR--VALVGDAAHRVHPLAGQGVNLGFGDVASLVKAL 367


                  ..
gi 586456     342 KK 343
Cdd:TIGR01989 368 AE 369
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
5-334 7.63e-09

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 57.61  E-value: 7.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      5 VAIIGAGLVGCLAALAFSKEGYNV-------TLYDFrqdPR---LDTTKNKNLKSINLAisargidalksidpdacEHIL 74
Cdd:PRK06183  13 VVIVGAGPVGLTLANLLGQYGVRVlvlerwpTLYDL---PRavgIDDEALRVLQAIGLA-----------------DEVL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     75 QDMIPMKGRMIHDLKG-------RQESQLYGLHgeAINSINRSVLNNSLLDELEK-STTELKFGHKLVKIEWTDDKQICH 146
Cdd:PRK06183  73 PHTTPNHGMRFLDAKGrclaeiaRPSTGEFGWP--RRNAFHQPLLEAVLRAGLARfPHVRVRFGHEVTALTQDDDGVTVT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    147 FAIGEDlkTPHTEKYDFVIGCDGAYSATRSQMqrKVEMD---FSQEYMNlryIELYIPPTEEFKPN------------Yg 211
Cdd:PRK06183 151 LTDADG--QRETVRARYVVGCDGANSFVRRTL--GVPFEdltFPERWLV---VDVLIANDPLGGPHtyqycdparpytS- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    212 gnFAIAPDHLhiwpRHKFMLiaLANSDGsftstffgskDQISDLitskSRVREfLIENF---PDIINImdLDDAVKRFIT 288
Cdd:PRK06183 223 --VRLPHGRR----RWEFML--LPGETE----------EQLASP----ENVWR-LLAPWgptPDDAEL--IRHAVYTFHA 277

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 586456    289 YPKESLVCvnckpydvpgGKAILLGDAAHAMVPFYGQGMNCGFEDV 334
Cdd:PRK06183 278 RVADRWRS----------GRVLLAGDAAHLMPPFAGQGMNSGIRDA 313
PRK06475 PRK06475
FAD-binding protein;
1-408 3.23e-07

FAD-binding protein;


Pssm-ID: 180582 [Multi-domain]  Cd Length: 400  Bit Score: 52.13  E-value: 3.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQdpRLDT-------TKNKNLKSINLAISARGIDAlkSIDPDACEhi 73
Cdd:PRK06475   1 TRGSPLIAGAGVAGLSAALELAARGWAVTIIEKAQ--ELSEvgaglqlAPNAMRHLERLGVADRLSGT--GVTPKALY-- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     74 LQDMIPMKGRMIHDLKGRQESQLyglHGEAInSINRSVLNNSLLDE-LEKSTTELKFGHKLVkiewtDDKQICHFAIGED 152
Cdd:PRK06475  75 LMDGRKARPLLAMQLGDLARKRW---HHPYI-VCHRADLQSALLDAcRNNPGIEIKLGAEMT-----SQRQTGNSITATI 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    153 LKTPHTEKYD--FVIGCDGAYSATRSQMQRKvEMDFS--------QEYMNLRYIELYIPPTEEFKPNYGGNFAiapdHLH 222
Cdd:PRK06475 146 IRTNSVETVSaaYLIACDGVWSMLRAKAGFS-KARFSghiawrttLAADALPASFLSAMPEHKAVSAWLGNKA----HFI 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    223 IWPRHK---FMLIALA---NSDGSFTSTffGSKDQISDLITSKSrvreflienfPDIINIMDLDD----------AVKRF 286
Cdd:PRK06475 221 AYPVKGgkfFNFVAITggeNPGEVWSKT--GDKAHLKSIYADWN----------KPVLQILAAIDewtywplfemADAQF 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    287 ITYPKEslvcvnckpydvpggkaILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKkhSGDRSRAFTEYTQTRHKdlvSI 366
Cdd:PRK06475 289 VGPDRT-----------------IFLGDASHAVTPFAAQGAAMAIEDAAALAEALD--SDDQSAGLKRFDSVRKE---RI 346

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 586456    367 TELAKR-NYKEMSHDVTSKRFLLRKKLDALFS--IIMKD-KWIPLY 408
Cdd:PRK06475 347 AAVAKRgQLNRFAYHATGIFALGRNMLFAIRSpeSFLKDlDWLYGY 392
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
306-367 2.00e-06

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 49.90  E-value: 2.00e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 586456    306 GGKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDR--SRAFTEYTQTRHKDLVSIT 367
Cdd:PRK07494 279 AGRTALVGEAAHVFPPIGAQGLNLGLRDVATLVEIVEDRPEDPgsAAVLAAYDRARRPDILSRT 342
PRK06617 PRK06617
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 4-362 2.29e-06

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 168629 [Multi-domain]  Cd Length: 374  Bit Score: 49.54  E-value: 2.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      4 SVAIIGAGLVGCLAALAFSKEGYNVTLY--------DFRQDPRldTTknknlksinlAISARGIDALKSIDP----DACE 71
Cdd:PRK06617   3 NTVILGCGLSGMLTALSFAQKGIKTTIFesksvkspEFFKDIR--TT----------ALTPHSKNFLFSIDIweelEKFV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     72 HILQDM--IPMKGRMIHDLKGRQESQL-YGLHGEAINSINRS-VLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQIchf 147
Cdd:PRK06617  71 AEMQDIyvVDNKASEILDLRNDADAVLgYVVKNSDFKKILLSkITNNPLITLIDNNQYQEVISHNDYSIIKFDDKQI--- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    148 aigedlktphteKYDFVIGCDGAYSATRSQMqrkvemdFSQEYMNLRYIELYIPPTEEfKPNYggNFAIApdhlHIWPRH 227
Cdd:PRK06617 148 ------------KCNLLIICDGANSKVRSHY-------FANEIEKPYQTALTFNIKHE-KPHE--NCAME----HFLPLG 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    228 KFMLIALANSDGSfTSTFFGSKDQISDLITSKSRVREFLIE-NFPDIINIMDLDDAVKRFityPKESLVcVNCKPYDvpg 306
Cdd:PRK06617 202 PFALLPLKDQYAS-SVIWSTSSDQAALIVNLPVEEVRFLTQrNAGNSLGKITIDSEISSF---PLKARI-ANRYFHN--- 273

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 586456    307 gKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSgdrsrAFTEYTQTRHKD 362
Cdd:PRK06617 274 -RIVLIADTAHTVHPLAGQGLNQGIKDIEILSMIVSNNG-----TLQEYQKLRQED 323
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
311-367 6.29e-06

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 48.03  E-value: 6.29e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 586456    311 LLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDRS----RAFTEYTQTRHKDLVSIT 367
Cdd:PRK07608 284 LVGDAAHLIHPLAGQGMNLGLRDVAALADVLAGREPFRDlgdlRLLRRYERARREDILALQ 344
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 5-32 8.76e-06

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 48.30  E-value: 8.76e-06
                         10        20
                 ....*....|....*....|....*...
gi 586456      5 VAIIGAGLVGCLAALAFSKEGYNVTLYD 32
Cdd:PRK01747 263 AAIIGGGIAGAALALALARRGWQVTLYE 290
PRK08163 PRK08163
3-hydroxybenzoate 6-monooxygenase;
307-359 1.72e-05

3-hydroxybenzoate 6-monooxygenase;


Pssm-ID: 181262 [Multi-domain]  Cd Length: 396  Bit Score: 46.95  E-value: 1.72e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 586456    307 GKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDRSRAFTEYTQTR 359
Cdd:PRK08163 286 GRVTLLGDAAHPMTQYMAQGACMALEDAVTLGKALEGCDGDAEAAFALYESVR 338
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
5-37 2.46e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 46.44  E-value: 2.46e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 586456     5 VAIIGAGLVGCLAALAFSKEGYNVTLYDfRQDP 37
Cdd:COG0665   5 VVVIGGGIAGLSTAYHLARRGLDVTVLE-RGRP 36
PRK05335 PRK05335
tRNA (uracil-5-)-methyltransferase Gid; Reviewed
 1-34 7.14e-05

tRNA (uracil-5-)-methyltransferase Gid; Reviewed


Pssm-ID: 235416  Cd Length: 436  Bit Score: 45.14  E-value: 7.14e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 586456      1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFR 34
Cdd:PRK05335   1 MMKPVNVIGAGLAGSEAAWQLAKRGVPVELYEMR 34
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 5-44 8.35e-05

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 44.70  E-value: 8.35e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 586456       5 VAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKN 44
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSGASGR 41
PRK06126 PRK06126
hypothetical protein; Provisional
 107-383 1.07e-04

hypothetical protein; Provisional


Pssm-ID: 235704 [Multi-domain]  Cd Length: 545  Bit Score: 44.60  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    107 INRSVLNNSLLDELEKS-TTELKFGHKLVKIEwTDDKQICHFAIGEDLKTPHTEKYDFVIGCDGAYSATRS----QMQRK 181
Cdd:PRK06126 123 IPQKYLEPILLEHAAAQpGVTLRYGHRLTDFE-QDADGVTATVEDLDGGESLTIRADYLVGCDGARSAVRRslgiSYEGT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    182 VEMDFSQEYMnLRYIELYIPptEEFKPNYGgNFAIAPDhlhIWPrhkfMLIALANSDGSFTSTFFGSKDqisDLITSKSR 261
Cdd:PRK06126 202 SGLQRDLSIY-IRAPGLAAL--VGHDPAWM-YWLFNPD---RRG----VLVAIDGRDEWLFHQLRGGED---EFTIDDVD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    262 VREFLI----ENFPdiINIMDLDDAVKRFITYPKESlvcvnckpydvpGGKAILLGDAAHAMVPFYGQGMNCGFEDVR-- 335
Cdd:PRK06126 268 ARAFVRrgvgEDID--YEVLSVVPWTGRRLVADSYR------------RGRVFLAGDAAHLFTPTGGYGMNTGIGDAVnl 333

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 586456    336 --ILMALLKKHSGDRSRAftEYTQTRHKDLVSITELAKRNYKEMSHDVTS 383
Cdd:PRK06126 334 awKLAAVLNGWAGPALLD--SYEAERRPIAARNTDYARRNADALGSFPVP 381
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 5-341 1.24e-04

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 44.20  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456      5 VAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLKsINlAISARGIDALKSIDpdACEHILQdmipMKG-- 82
Cdd:PRK08020   8 IAIVGGGMVGAALALGLAQHGFSVAVLEHAAPAPFDADSQPDVR-IS-AISAASVALLKGLG--VWDAVQA----MRShp 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456     83 ------------RMIHDLKGRQESQLyGLHGEainsiNRsVLNNSLLDELEK-STTELKFGHKLVKIEWTDDKQICHFAI 149
Cdd:PRK08020  80 yrrletwewetaHVVFDAAELKLPEL-GYMVE-----NR-VLQLALWQALEAhPNVTLRCPASLQALQRDDDGWELTLAD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    150 GEDLKTPhtekydFVIGCDGAYSATRsQMqrkvemdfsqeymnlryielyippteefkpnyggnfaiAPDHLHIWP-RHK 228
Cdd:PRK08020 153 GEEIQAK------LVIGADGANSQVR-QM--------------------------------------AGIGVHGWQyRQS 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586456    229 FMLIALANSDGSFTST---FFGSK--------DQISDLI--TSKSRVREF-----------LIENFPDIINimdlddAVK 284
Cdd:PRK08020 188 CMLISVKCENPPGDSTwqqFTPSGpraflplfDNWASLVwyDSPARIRQLqamsmaqlqqeIAAHFPARLG------AVT 261

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 586456    285 RFIT--YPkesLVCVNCKPYDVPGgkAILLGDAAHAMVPFYGQGMNCGFEDVRILMALL 341
Cdd:PRK08020 262 PVAAgaFP---LTRRHALQYVQPG--LALVGDAAHTINPLAGQGVNLGYRDVDALLDVL 315
PRK07045 PRK07045
putative monooxygenase; Reviewed
 309-360 2.22e-04

putative monooxygenase; Reviewed


Pssm-ID: 136171 [Multi-domain]  Cd Length: 388  Bit Score: 43.36  E-value: 2.22e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 586456    309 AILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDR---SRAFTEYTQTRH 360
Cdd:PRK07045 287 VVLLGDAAHSIHPITGQGMNLAIEDAGELGACLDLHLSGQialADALERFERIRR 341
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
4-32 5.65e-04

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 41.79  E-value: 5.65e-04
                        10        20
                ....*....|....*....|....*....
gi 586456     4 SVAIIGAGLVGCLAALAFSKEGYNVTLYD 32
Cdd:COG3380   5 DIAIIGAGIAGLAAARALQDAGHEVTVFE 33
PRK08013 PRK08013
oxidoreductase; Provisional
 311-343 6.28e-04

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 41.95  E-value: 6.28e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 586456    311 LLGDAAHAMVPFYGQGMNCGFEDVRILMALLKK 343
Cdd:PRK08013 286 LVGDAAHTIHPLAGQGVNLGFMDAAELIAELRR 318
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 1-47 7.49e-04

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 41.53  E-value: 7.49e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 586456      1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDpRLD---TTKNKNL 47
Cdd:PRK07530   3 AIKKVGVIGAGQMGNGIAHVCALAGYDVLLNDVSAD-RLEaglATINGNL 51
PRK08773 PRK08773
UbiH/UbiF family hydroxylase;
307-343 8.28e-04

UbiH/UbiF family hydroxylase;


Pssm-ID: 181552 [Multi-domain]  Cd Length: 392  Bit Score: 41.39  E-value: 8.28e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 586456    307 GKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKK 343
Cdd:PRK08773 282 GRVLTLGDAAHVVHPLAGQGVNLGLRDVAALQQLVRQ 318
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-37 1.04e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 37.51  E-value: 1.04e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 586456       7 IIGAGLVGCLAALAFSKEGYNVTLYDFRQDP 37
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRL 31
PRK06185 PRK06185
FAD-dependent oxidoreductase;
305-359 1.15e-03

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 41.00  E-value: 1.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 586456    305 PGgkAILLGDAAHAMVPFYGQGMNCGFEDV----RILMALLKKHSGDrSRAFTEYtQTR 359
Cdd:PRK06185 284 PG--LLCIGDAAHAMSPVGGVGINLAIQDAvaaaNILAEPLRRGRVS-DRDLAAV-QRR 338
TrmFO COG1206
Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and ...
 2-34 2.22e-03

Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and biogenesis]; Folate-dependent tRNA-U54 methylase TrmFO/GidA is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440819  Cd Length: 436  Bit Score: 40.43  E-value: 2.22e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 586456     2 SESVAIIGAGLVGCLAALAFSKEGYNVTLYDFR 34
Cdd:COG1206   1 MKPVTVIGGGLAGSEAAWQLAERGVPVRLYEMR 33
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-39 2.67e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 39.84  E-value: 2.67e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 586456     1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRqdPRL 39
Cdd:COG3349   2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEAR--PRL 38
PRK07538 PRK07538
hypothetical protein; Provisional
 307-373 3.24e-03

hypothetical protein; Provisional


Pssm-ID: 236046 [Multi-domain]  Cd Length: 413  Bit Score: 39.88  E-value: 3.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586456    307 GKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHsGDRSRAFTEYTQTRhkdLVSITELAKRN 373
Cdd:PRK07538 297 GRVTLLGDAAHPMYPVGSNGASQAILDARALADALAAH-GDPEAALAAYEAER---RPATAQIVLAN 359
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 5-57 3.49e-03

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 39.45  E-value: 3.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 586456      5 VAIIGAGLVGCLAALAFSKEGYNVTLYDfRQDPRLDTTKNKNLKSINLAISAR 57
Cdd:PRK06522   3 IAILGAGAIGGLFGAALAQAGHDVTLVA-RRGAHLDALNENGLRLEDGEITVP 54
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
311-334 3.60e-03

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 39.58  E-value: 3.60e-03
                         10        20
                 ....*....|....*....|....
gi 586456    311 LLGDAAHAMVPFYGQGMNCGFEDV 334
Cdd:PRK07333 284 LVGDAAHGIHPIAGQGLNLGLKDV 307
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 295-341 3.99e-03

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 39.43  E-value: 3.99e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 586456    295 VCV-----NCKPYDVPGgkAILLGDAAHAMVPFYGQGMNCGFEDVRILMALL 341
Cdd:PRK05714 270 LCVplrqrHAKRYVEPG--LALIGDAAHTIHPLAGQGVNLGFLDAAVLAEVL 319
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 1-37 4.00e-03

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 39.26  E-value: 4.00e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 586456      1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDfrQDP 37
Cdd:PRK06129   1 PMGSVAIIGAGLIGRAWAIVFARAGHEVRLWD--ADP 35
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 4-30 5.39e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 35.64  E-value: 5.39e-03
                          10        20
                  ....*....|....*....|....*..
gi 586456       4 SVAIIGAGLVGCLAALAFSKEGYNVTL 30
Cdd:pfam00070   1 RVVVVGGGYIGLELAGALARLGSKVTV 27
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 1-42 6.61e-03

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 38.85  E-value: 6.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 586456      1 MSeSVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTT 42
Cdd:PRK12409   1 MS-HIAVIGAGITGVTTAYALAQRGYQVTVFDRHRYAAMETS 41
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 1-32 7.13e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 38.45  E-value: 7.13e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 586456       1 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYD 32
Cdd:pfam07992 151 LPKRVVVVGGGYIGVELAAALAKLGKEVTLIE 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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