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Conserved domains on  [gi|3041659|sp|P40968|]
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RecName: Full=Pre-mRNA-processing factor 17; AltName: Full=Cell division control protein 40

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-408 1.04e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.40  E-value: 1.04e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  154 VIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDfYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW 233
Cdd:cd00200  43 LLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD-LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  234 DTETGKVKTRlhLNSTPADVESRPTNP-HEFIVGLSNSKILH-YDdrvSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311
Cdd:cd00200 121 DVETGKCLTT--LRGHTDWVNSVAFSPdGTFVASSSQDGTIKlWD---LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  312 SEDKTVRIWENQINVPIKQISdtaQHSMPFLNV--HPSQNYFCAQSMDNRIYSFSLKpkyKRHPKKIFKGHSSAGYgiSL 389
Cdd:cd00200 196 SSDGTIKLWDLSTGKCLGTLR---GHENGVNSVafSPDGYLLASGSEDGTIRVWDLR---TGECVQTLSGHTNSVT--SL 267

                       250       260
                ....*....|....*....|.
gi 3041659  390 AFSGDGRYICSG--DSKSRLF 408
Cdd:cd00200 268 AWSPDGKRLASGsaDGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-408 1.04e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.40  E-value: 1.04e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  154 VIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDfYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW 233
Cdd:cd00200  43 LLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD-LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  234 DTETGKVKTRlhLNSTPADVESRPTNP-HEFIVGLSNSKILH-YDdrvSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311
Cdd:cd00200 121 DVETGKCLTT--LRGHTDWVNSVAFSPdGTFVASSSQDGTIKlWD---LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  312 SEDKTVRIWENQINVPIKQISdtaQHSMPFLNV--HPSQNYFCAQSMDNRIYSFSLKpkyKRHPKKIFKGHSSAGYgiSL 389
Cdd:cd00200 196 SSDGTIKLWDLSTGKCLGTLR---GHENGVNSVafSPDGYLLASGSEDGTIRVWDLR---TGECVQTLSGHTNSVT--SL 267

                       250       260
                ....*....|....*....|.
gi 3041659  390 AFSGDGRYICSG--DSKSRLF 408
Cdd:cd00200 268 AWSPDGKRLASGsaDGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
153-436 1.27e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 1.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  153 KVIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDFyHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKI 232
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  233 WDTETGKVKTRLhlNSTPADVESrptnphefiVGLS-NSKIL---HYDDRV----SENQGLVQTYDHHLSSILALKYFPD 304
Cdd:COG2319 189 WDLATGKLLRTL--TGHTGAVRS---------VAFSpDGKLLasgSADGTVrlwdLATGKLLRTLTGHSGSVRSVAFSPD 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  305 GSKFISSSEDKTVRIWenqiNVPIKQISDTAQHSMPFLN---VHPSQNYFCAQSMDNRIYSFSLKpkyKRHPKKIFKGHS 381
Cdd:COG2319 258 GRLLASGSADGTVRLW----DLATGELLRTLTGHSGGVNsvaFSPDGKLLASGSDDGTVRLWDLA---TGKLLRTLTGHT 330

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3041659  382 SAGYgiSLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNkPITQVDWHP 436
Cdd:COG2319 331 GAVR--SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSP 382
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 285-321 5.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 5.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 3041659     285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
197-234 1.29e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.29e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 3041659    197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 178-363 1.61e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659   178 ILSGGNDHTIKIWDFYHDyECLRDFQGHNKPIKALRFTEDCQSFLSS-SFDRSVKIWDTETG------KVKTRLHLNSTP 250
Cdd:PLN00181 548 VASSNFEGVVQVWDVARS-QLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSINQGvsigtiKTKANICCVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659   251 ADvesrptNPHEFIVGLSNSKILHYDDRvSENQGLVQTYDHHlsSILALKYFPDGSKFISSSEDKTVRIWEnqINVPIKQ 330
Cdd:PLN00181 627 SE------SGRSLAFGSADHKVYYYDLR-NPKLPLCTMIGHS--KTVSYVRFVDSSTLVSSSTDNTLKLWD--LSMSISG 695

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 3041659   331 ISDTAQHSMP-------FLNVHPSQNYFCAQSMDNRIYSF 363
Cdd:PLN00181 696 INETPLHSFMghtnvknFVGLSVSDGYIATGSETNEVFVY 735
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-408 1.04e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.40  E-value: 1.04e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  154 VIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDfYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW 233
Cdd:cd00200  43 LLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD-LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  234 DTETGKVKTRlhLNSTPADVESRPTNP-HEFIVGLSNSKILH-YDdrvSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311
Cdd:cd00200 121 DVETGKCLTT--LRGHTDWVNSVAFSPdGTFVASSSQDGTIKlWD---LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  312 SEDKTVRIWENQINVPIKQISdtaQHSMPFLNV--HPSQNYFCAQSMDNRIYSFSLKpkyKRHPKKIFKGHSSAGYgiSL 389
Cdd:cd00200 196 SSDGTIKLWDLSTGKCLGTLR---GHENGVNSVafSPDGYLLASGSEDGTIRVWDLR---TGECVQTLSGHTNSVT--SL 267

                       250       260
                ....*....|....*....|.
gi 3041659  390 AFSGDGRYICSG--DSKSRLF 408
Cdd:cd00200 268 AWSPDGKRLASGsaDGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-451 3.11e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 3.11e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  155 IRNYPGHPEGTTALKFLPKtGHLILSGGNDHTIKIWDFYHDyECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  235 TETGKVKTRL--HLNstpaDVESRPTNPHEFIV--GLSNSKILHYDdrVSENQgLVQTYDHHLSSILALKYFPDGsKFI- 309
Cdd:cd00200  80 LETGECVRTLtgHTS----YVSSVAFSPDGRILssSSRDKTIKVWD--VETGK-CLTTLRGHTDWVNSVAFSPDG-TFVa 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  310 SSSEDKTVRIWENQINVPIKQISDtaqHSMP--FLNVHPSQNYFCAQSMDNRIYSFSLKpkyKRHPKKIFKGHSSAGYgi 387
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATLTG---HTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENGVN-- 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3041659  388 SLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNniKIPG-NKPITQVDWHPqeTSKVICSGAAGKI 451
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ--TLSGhTNSVTSLAWSP--DGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
153-436 1.27e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 1.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  153 KVIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDFyHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKI 232
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  233 WDTETGKVKTRLhlNSTPADVESrptnphefiVGLS-NSKIL---HYDDRV----SENQGLVQTYDHHLSSILALKYFPD 304
Cdd:COG2319 189 WDLATGKLLRTL--TGHTGAVRS---------VAFSpDGKLLasgSADGTVrlwdLATGKLLRTLTGHSGSVRSVAFSPD 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  305 GSKFISSSEDKTVRIWenqiNVPIKQISDTAQHSMPFLN---VHPSQNYFCAQSMDNRIYSFSLKpkyKRHPKKIFKGHS 381
Cdd:COG2319 258 GRLLASGSADGTVRLW----DLATGELLRTLTGHSGGVNsvaFSPDGKLLASGSDDGTVRLWDLA---TGKLLRTLTGHT 330

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3041659  382 SAGYgiSLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNkPITQVDWHP 436
Cdd:COG2319 331 GAVR--SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
153-414 4.59e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 4.59e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  153 KVIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDFyHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKI 232
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  233 WDTETGKVKTRL-HLNSTPADVESRPTNphEFIVGLSNSKILH-YDdrVSENQgLVQTYDHHLSSILALKYFPDGSKFIS 310
Cdd:COG2319 231 WDLATGKLLRTLtGHSGSVRSVAFSPDG--RLLASGSADGTVRlWD--LATGE-LLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  311 SSEDKTVRIWENQINVPIKQISDtaqHSMPFLNV--HPSQNYFCAQSMDNRIYSFSLKpkyKRHPKKIFKGHSSAGYgiS 388
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLTG---HTGAVRSVafSPDGKTLASGSDDGTVRLWDLA---TGELLRTLTGHTGAVT--S 377

                       250       260
                ....*....|....*....|....*.
gi 3041659  389 LAFSGDGRYICSGDSKSRLFTWDWNT 414
Cdd:COG2319 378 VAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
153-455 8.46e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 8.46e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  153 KVIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDFYHDyECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKI 232
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATG-LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  233 WDTETGKVKTRLhlnstpadvesrpTNPHEFIVGLS---NSKIL---HYDDRV----SENQGLVQTYDHHLSSILALKYF 302
Cdd:COG2319 147 WDLATGKLLRTL-------------TGHSGAVTSVAfspDGKLLasgSDDGTVrlwdLATGKLLRTLTGHTGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  303 PDGSKFISSSEDKTVRIWENQINVPIKQISDtaqHSMPFLNV--HPSQNYFCAQSMDNRIYSFSLKPkykRHPKKIFKGH 380
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDLATGKLLRTLTG---HSGSVRSVafSPDGRLLASGSADGTVRLWDLAT---GELLRTLTGH 287

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3041659  381 SSAGYgiSLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNkPITQVDWHPQEtSKVICSGAAGKIYVCD 455
Cdd:COG2319 288 SGGVN--SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDG-KTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-321 1.96e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.96e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  153 KVIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDFYHDyECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKI 232
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTG-KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  233 WDTETGKVKTRL--HLNStpadVESRPTNPHE--FIVGLSNSKILHYDdrvSENQGLVQTYDHHLSSILALKYFPDGSKF 308
Cdd:cd00200 204 WDLSTGKCLGTLrgHENG----VNSVAFSPDGylLASGSEDGTIRVWD---LRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                       170
                ....*....|...
gi 3041659  309 ISSSEDKTVRIWE 321
Cdd:cd00200 277 ASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 198-453 1.70e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 1.70e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDd 277
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  278 rvSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDtaqHSMP--FLNVHPSQNYFCAQS 355
Cdd:cd00200  80 --LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG---HTDWvnSVAFSPDGTFVASSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  356 MDNRIYSFSLKPKYkrhPKKIFKGHSSAGYgiSLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPgNKPITQVDWH 435
Cdd:cd00200 155 QDGTIKLWDLRTGK---CVATLTGHTGEVN--SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFS 228

                       250
                ....*....|....*....
gi 3041659  436 PqeTSKVICSGAA-GKIYV 453
Cdd:cd00200 229 P--DGYLLASGSEdGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 152-234 6.29e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 6.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659  152 KKVIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWDfYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVK 231
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                ...
gi 3041659  232 IWD 234
Cdd:cd00200 287 IWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 285-321 5.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 5.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 3041659     285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 197-234 1.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 3041659     197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
197-234 1.29e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.29e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 3041659    197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-191 7.21e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 3041659     151 PKKVIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWD 191
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
285-321 1.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 3041659    285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 178-363 1.61e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659   178 ILSGGNDHTIKIWDFYHDyECLRDFQGHNKPIKALRFTEDCQSFLSS-SFDRSVKIWDTETG------KVKTRLHLNSTP 250
Cdd:PLN00181 548 VASSNFEGVVQVWDVARS-QLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSINQGvsigtiKTKANICCVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659   251 ADvesrptNPHEFIVGLSNSKILHYDDRvSENQGLVQTYDHHlsSILALKYFPDGSKFISSSEDKTVRIWEnqINVPIKQ 330
Cdd:PLN00181 627 SE------SGRSLAFGSADHKVYYYDLR-NPKLPLCTMIGHS--KTVSYVRFVDSSTLVSSSTDNTLKLWD--LSMSISG 695

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 3041659   331 ISDTAQHSMP-------FLNVHPSQNYFCAQSMDNRIYSF 363
Cdd:PLN00181 696 INETPLHSFMghtnvknFVGLSVSDGYIATGSETNEVFVY 735
PTZ00420 PTZ00420
coronin; Provisional
 155-239 3.64e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659   155 IRNYP-----GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRD-------FQGHNKPIKALRFTEDCQSFL 222
Cdd:PTZ00420  62 MRKPPviklkGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEikdpqciLKGHKKKISIIDWNPMNYYIM 141

                         90
                 ....*....|....*...
gi 3041659   223 -SSSFDRSVKIWDTETGK 239
Cdd:PTZ00420 142 cSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
152-191 9.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.13e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 3041659    152 KKVIRNYPGHPEGTTALKFLPkTGHLILSGGNDHTIKIWD 191
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 168-270 5.02e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.77  E-value: 5.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041659   168 LKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTeDCQSFLSSSFDRSVKIWDTETGKVKtrlhLN 247
Cdd:PLN00181 623 VQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISG----IN 697

                         90       100
                 ....*....|....*....|...
gi 3041659   248 STPADVESRPTNPHEFiVGLSNS 270
Cdd:PLN00181 698 ETPLHSFMGHTNVKNF-VGLSVS 719
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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