|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-452 |
2.38e-100 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 305.27 E-value: 2.38e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 15 AAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAA 94
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 95 ASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIG 174
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 175 ALGILASgsvmnnikgkaekldwtgfllfalglvgitlgldllgesqhnssvtysilvvgilllvtycgyaknnenAILP 254
Cdd:cd17503 161 ILALLLA---------------------------------------------------------------------PLLD 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 255 LSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSA 334
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 335 LLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILN 414
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1176313 415 LYRHFF-----------SASDCLPQAFSYTFLTSSLFVIALVWSLMKLH 452
Cdd:cd17503 332 NRTQFHhsrlsellaqqVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
1-444 |
7.52e-95 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 294.33 E-value: 7.52e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 1 MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRS 80
Cdd:PRK10504 1 MTDLPDSVRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 81 AVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIH 160
Cdd:PRK10504 81 AIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 161 ASWHWIFLINIPIGALGILASGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT 240
Cdd:PRK10504 161 ASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 241 YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRI 320
Cdd:PRK10504 241 YLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 321 LNRWGYKTTLISSALLMA------GSVISMAWldkqsslTWII-CNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTV 393
Cdd:PRK10504 321 VNRFGYRRVLVATTLGLAlvsllfMLVALLGW-------YYLLpFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSL 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1176313 394 LSIVQQVGIGFGIAVSSIILNLY--RHFFSASDCLPQAFSYTFLTSSLfVIAL 444
Cdd:PRK10504 394 LSMIMQLSMSIGVTIAGLLLGLFgqQHVSVDSGATHTVFMYTYLCMAL-IIAL 445
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
11-420 |
6.44e-59 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 201.07 E-value: 6.44e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 11 LAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSV 90
Cdd:TIGR00711 3 LTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 91 ACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLIN 170
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 171 IPIGALGILASGSVMNNIKGKA-EKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSIL-VVGILLLVTYCGYAKNN 248
Cdd:TIGR00711 163 VPIGIIVVVVAFFILPRDKPAAsENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILsITGLVAIIAFVVWELTD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 249 ENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKT 328
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRK 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 329 TLISSALLMA-GSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIA 407
Cdd:TIGR00711 323 LVTIGLILYAvGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402
|
410
....*....|...
gi 1176313 408 VSSIILNLYRHFF 420
Cdd:TIGR00711 403 LITTILTNRTQFH 415
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-413 |
2.05e-50 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 175.44 E-value: 2.05e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 16 AMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAA 95
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 96 SNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGA 175
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 176 LGILAsgsvmnnikgkaekldwtgfllfalglvgitlgldllgesqhnssvtysilvvgilllvtycgyaknnenailpl 255
Cdd:cd17321 162 VALLL--------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 256 slfrTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSAL 335
Cdd:cd17321 167 ----ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176313 336 LMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIIL 413
Cdd:cd17321 243 LTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
17-408 |
3.21e-40 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 147.32 E-value: 3.21e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 17 MALFMQSLDATILNTALPAISSDLHKPAfEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAAS 96
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLS-LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 97 NLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGAl 176
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 177 gilasgsvmnnikgkaekldwtgfllfalglvgitlgldllgesqhnssvtysilvvgilllvtycgyaknnenailpLS 256
Cdd:cd17502 161 ------------------------------------------------------------------------------LA 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 257 LFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWG-YKTTLISSAL 335
Cdd:cd17502 163 LALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTI 242
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176313 336 LMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAV 408
Cdd:cd17502 243 LMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-402 |
1.39e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 145.89 E-value: 1.39e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 1 MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRS 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 81 AVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIH 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 161 ASWHWIFLINIPIGALGILASGSVMNNIKGKAEKLDWTGFllfalglvgitlgldllgesqhnssvtysilvvgilllvt 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL---------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 241 ycgyaknnenailpLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRI 320
Cdd:COG2814 201 --------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 321 LNRWGYKTTLISSALLMAGSVISMAWLdkqSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQV 400
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
..
gi 1176313 401 GI 402
Cdd:COG2814 344 GG 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-291 |
3.00e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 116.06 E-value: 3.00e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 9 RGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILG 88
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 89 SVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFL 168
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 169 INIPIGALGILASGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVTYCGYAKNN 248
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1176313 249 ENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLS 291
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
16-449 |
8.71e-28 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 113.83 E-value: 8.71e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 16 AMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAA 95
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 96 SNLESLILARVIQGIGGAfMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGA 175
Cdd:cd17504 82 PNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 176 LGILASgsvmnnikgkaekldwtgfllfalglvgitlgldllgesqhnssvtysilvvgilllvtycgyaknnenAILPL 255
Cdd:cd17504 161 LLAALV---------------------------------------------------------------------PLIDL 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 256 SLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQL----SFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLI 331
Cdd:cd17504 172 RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 332 SSALLMAGSVISMAWLdkQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSI 411
Cdd:cd17504 252 IGLVISAVGLLLLALL--HSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGA 329
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1176313 412 ILNLYR-HFFSASDCLPQAFSYTFLTSS-LFVIALVWSLM 449
Cdd:cd17504 330 ILTTYTvSITSGGVPTEGAYVLAFLIGAaLALAALLLSLL 369
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
11-414 |
6.29e-25 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 105.74 E-value: 6.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 11 LAWVAAMALFMQsLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSV 90
Cdd:cd17320 1 LLLLALLVALGP-LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 91 ACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLIn 170
Cdd:cd17320 80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 171 ipigalgilasgsvmnnikgkaekldwtgflLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLlvtycgyaknnen 250
Cdd:cd17320 159 -------------------------------LALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAY------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 251 ailpLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTL 330
Cdd:cd17320 195 ----KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 331 ISSALLM--AGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVgDLSKQQSGTGSTVLSIVQQVGIGFGIAV 408
Cdd:cd17320 271 RLGLLLLlaAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL-EPFPHVAGTASALLGFLQFLIGALAGAL 349
|
....*.
gi 1176313 409 SSIILN 414
Cdd:cd17320 350 VGLLPN 355
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
16-405 |
1.62e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.04 E-value: 1.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 16 AMALFMQSLDATILNTALP-AISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAA 94
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 95 ASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIG 174
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 175 ALGILASGSVMNNIKGKAEKldwtgfllfalglvgitlgldllgesqhnssvtysilvvgilllvtycGYAKNNENAILP 254
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPK------------------------------------------------PAEEARLSLIVA 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 255 LSLFRTRTFRLGIIANIFIRLSASGVPFLLPLmFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSA 334
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176313 335 LLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFG 405
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
14-414 |
3.34e-21 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 96.16 E-value: 3.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 14 VAAMALFMQSLDATILNTALPAISSDLHkPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACA 93
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 94 AASNLESLILARVIQGIGGA--FMMPVARLAIiqaVPKQQLVNAWNLMATAGLIGPILGPILGGWLVI--HASWHWIFLI 169
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGtqGLGAAVASEL---VPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 170 NIPIGALGILASG----------SVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGES-QHNSSVTYSILVVGILLL 238
Cdd:cd06179 158 NAIFNALALILLFffyhppprpqLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPyPWSSAHVIAPLVIGGVLL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 239 VTYCGY-AKNNENAILPLSLF-RTRTFrlgiiANIFIRLSASGVPF-----LLPLMFQLSFGYSAEMSGWLLAPIALISV 311
Cdd:cd06179 238 IAFGLYeWKGTKDGLLPPRLLfRGRNF-----ALILIVAFVEGMIFyslniFWPQQISLLFTTDPLKAGLYQLPFGLGTL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 312 MLKILIGRILNRWGY-KTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMwYGACMSIIFTSINTLAVGDLSKQQSGTG 390
Cdd:cd06179 313 FGAILAGLLLTKIKHiKWQLVAGFVLFTAFLALLALITPDNKALAIAFSVL-AGIGIGGPLVLAIVIVQLSVPPEDIGTA 391
|
410 420
....*....|....*....|....
gi 1176313 391 STVLSIVQQVGIGFGIAVSSIILN 414
Cdd:cd06179 392 SGLLGSARALGGAVGTAIFTSILS 415
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-423 |
2.59e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 92.25 E-value: 2.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 13 WVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVAC 92
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 93 AAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHaSWHWIFlinip 172
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPF----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 173 igalgilasgsvmnnikgkaekldwtgFLLFALGLVGItLGLDLLGESQHNSSVTYSILVVGIlllvtycgyaknnenai 252
Cdd:cd17474 156 ---------------------------FLLAALIPVAF-LAILFLLPEPKEKAKSSSATKLRD----------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 253 lPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILN-RWGYKTTLI 331
Cdd:cd17474 191 -LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILV 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 332 SSALLMAGSVISMAWLDkqsSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSI 411
Cdd:cd17474 270 IGLLLYALSLLLLGFVP---SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGL 346
|
410
....*....|....*
gi 1176313 412 ILNLYRH---FFSAS 423
Cdd:cd17474 347 LLEIFGLsapFLVGA 361
|
|
| MFS_effux_SdrM |
NF040895 |
multidrug efflux MFS transporter SdrM; |
17-342 |
9.74e-20 |
|
multidrug efflux MFS transporter SdrM;
Pssm-ID: 468830 [Multi-domain] Cd Length: 441 Bit Score: 91.18 E-value: 9.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 17 MALFMQSLDATILNTALPAISSDLHKPAfEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAAS 96
Cdd:NF040895 13 LIMFMAAIETSIISLALPTIKEDLNAGS-SISLVFTVYFIALVIANPIVGELLSRFKIIYITILGLLLFIIGSLMSGLSE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 97 NLESLILARVIQGIGGAFMMpvarlAIIQAVPKQ--QLVNAWNLMATAGL---IGPILGPILGGWLVIHASWHWIFLINI 171
Cdd:NF040895 92 TFTMLIISRIIQGLGAGVMM-----SLSQIVPKLafEIPLRYKIMGIVGSvwgISSIIGPLLGGGILEFATWHWLFFINI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 172 PIGALGI---LASGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLdllgESQHNSSVTYSILVVGILLLVTYCGYAKNN 248
Cdd:NF040895 167 PIAIIAIilvIFTFHFPEEETTSKTKFDVKGLTLFYIFIALLMFAV----LNQGHLWLNIISFILAIVVFFLLFKVEKKV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 249 ENAILPLSLFrTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKT 328
Cdd:NF040895 243 KNPFLPVKEF-NKSIILVFFTDFLIAMMLMGYNLYIPIYLQEHLGLSPLQSGLVIFPLSVAWLILNFNLAKIEAKLTRKG 321
|
330
....*....|....*
gi 1176313 329 TLISS-ALLMAGSVI 342
Cdd:NF040895 322 LYIGAfTLLIVCSIL 336
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
23-431 |
1.49e-19 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 90.94 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 23 SLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVA-LFIPLTAWA-AAKFGTLTVFRSAVFTfiLGSVACAAASNLES 100
Cdd:PRK14995 19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAgMVLPMGALGdRIGFKRLLMLGGTLFG--LASLAAAFSPTASW 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 101 LILARVIQGIGGAFMMPvARLAIIQA--VPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIgALGI 178
Cdd:PRK14995 97 LIATRALLAIGAAMIVP-ATLAGIRAtfTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPI-VLVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 179 LASGSVMnnIKGKAEKLDWTGFLLFALGLVGITLGLDLLGES----QHNSSVTYSILVVGILLLVTYCGYAKNNENAILP 254
Cdd:PRK14995 175 MGLTARY--VPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTalkgFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMID 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 255 LSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSA 334
Cdd:PRK14995 253 MRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGM 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 335 LLMAGSVISMAWLD--KQSSLTWIICNLMWYGACMSIIFTSINTLAVGdlSKQQSGTGSTVLSIVQQVGIGFGIAVSSII 412
Cdd:PRK14995 333 ALSALSFYGLAMTDfsTQQWQAWGLMALLGFSAASALLASTSAIMAAA--PPEKAAAAGAIETMAYELGAGLGIAIFGLL 410
|
410
....*....|....*....
gi 1176313 413 LNlyrHFFSASDCLPQAFS 431
Cdd:PRK14995 411 LS---RSYSASIRLPAGLP 426
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-443 |
8.97e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.63 E-value: 8.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 16 AMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAA 95
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 96 SNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLInipiga 175
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 176 lgilasgsvmnnikgkaekldwtgflLFALGLVGITLGLDLLGESQHNSSVTysilvvgilllvtycgyAKNNENAILPL 255
Cdd:cd17325 156 --------------------------CAALALLALVLALLLLPEPRPPPNKR-----------------AVSAARLRSGL 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 256 SLFRTRTFRLGIIANIFIRLSASGVPF-LLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSA 334
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEpFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 335 LLMAGSVISMAWLdkqSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILN 414
Cdd:cd17325 273 LLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
410 420
....*....|....*....|....*....
gi 1176313 415 LYrhffsasdclpqAFSYTFLTSSLFVIA 443
Cdd:cd17325 350 AF------------GFATPFLAAAALLLL 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-416 |
8.98e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.54 E-value: 8.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 11 LAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSV 90
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 91 ACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLIN 170
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 171 IPIGALGILAsgsvmnnikgkaekldwtgfllfalglvgitlgldllgesqhnssvtysilvvgilllvtycgyaknnen 250
Cdd:COG2271 171 GLPGLLLALL---------------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 251 ailplslfrtrTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGyKTTL 330
Cdd:COG2271 181 -----------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG-RRRK 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 331 ISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSS 410
Cdd:COG2271 249 LVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVG 328
|
....*.
gi 1176313 411 IILNLY 416
Cdd:COG2271 329 YLLDAT 334
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
13-413 |
3.07e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 79.90 E-value: 3.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 13 WVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVAC 92
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 93 AAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLInip 172
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 173 IGALGILAsgsvmnnikgkaekldwtgFLLFALglvgitlgldLLGESQHNSSVTYSILVVgilllvtycgyaknnenai 252
Cdd:cd17324 159 IAVLALLA-------------------ALLLWR----------LLPSLPPKKPGSLGLLSS------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 253 lPLSLFRTRTFRLGIIANIFIRLSASGV-PFLLPLMFQLSFGYSAEMSGWLLApIALISVMLKILIGRILNRWGYKTTLI 331
Cdd:cd17324 191 -LLLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRALLI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 332 SSALLMAGSVISMAWLdkQSSLTWIICNLMWyGACMSIIFTSINTLaVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSI 411
Cdd:cd17324 269 ALLLLAAALLLLTLLG--PSPLLLLVGLVLW-GLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAALGGL 344
|
..
gi 1176313 412 IL 413
Cdd:cd17324 345 VL 346
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
49-181 |
1.12e-14 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 70.76 E-value: 1.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 49 MAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVP 128
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1176313 129 KQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLInipIGALGILAS 181
Cdd:TIGR00880 82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLF---LAILALAAF 131
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-179 |
4.31e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 70.29 E-value: 4.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 24 LDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLIL 103
Cdd:cd17319 17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176313 104 ARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLInipIGALGIL 179
Cdd:cd17319 97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII---EGLLGLL 169
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
11-181 |
4.56e-13 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 70.49 E-value: 4.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 11 LAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSV 90
Cdd:TIGR00710 6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 91 ACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLIn 170
Cdd:TIGR00710 86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF- 164
|
170
....*....|.
gi 1176313 171 ipIGALGILAS 181
Cdd:TIGR00710 165 --LSLAGILLS 173
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-416 |
9.71e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 69.52 E-value: 9.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 5 SNAYRGLaWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFT 84
Cdd:COG2223 1 SGRWRVL-LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 85 FILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWH 164
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 165 WIFLINIPIGALGILASGSVMNNIKGKAEkldwtgfllfalglvgitlgldllgesqhnssvtysilvvgilllvtycgy 244
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAA--------------------------------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 245 AKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRW 324
Cdd:COG2223 189 AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 325 GYKTTLISSALLMAGSVISMAWLdkQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGF 404
Cdd:COG2223 269 GGRRVLLIVFALMALGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346
|
410
....*....|..
gi 1176313 405 GIAVSSIILNLY 416
Cdd:COG2223 347 GPLLFGALLDAT 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
4-396 |
1.44e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.11 E-value: 1.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 4 ESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVF 83
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 84 TFILGSVACAAASNLESLILARVIQGIGGAFMMpVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLV---IH 160
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLD-VAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllgLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 161 ASWHWIFLInipigalgilasgsvmnnikgkaekldwTGFLLFALGLVGITLGLDLLGESQhnssvtysilvvgilllvt 240
Cdd:COG0738 161 LSWHLPYLI----------------------------LAVLLLLLALLFLRSKLPEIEEEE------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 241 ycgyAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRI 320
Cdd:COG0738 194 ----EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176313 321 LNRWGYKTTLISSALLMAGSVISMAWLdkqSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSI 396
Cdd:COG0738 270 LKRFGPVRLLRLSALLAAVGLLLALLA---PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-414 |
1.89e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.61 E-value: 1.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 15 AAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAA 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 95 ASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIH--ASWHWIFLINIP 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 173 IGALGILASGSVMNNIKGKAEKLDWTGFLLfalglvgitlgldllgesqhnssvtysilvvgilllvtycgyaknnENAI 252
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSK----------------------------------------------SVLK 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 253 LPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLIs 332
Cdd:cd06174 195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL- 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 333 sALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSII 412
Cdd:cd06174 274 -LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
..
gi 1176313 413 LN 414
Cdd:cd06174 353 LA 354
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
26-181 |
9.04e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.44 E-value: 9.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 26 ATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILAR 105
Cdd:cd17323 15 SSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176313 106 VIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILAS 181
Cdd:cd17323 95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
32-449 |
1.14e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.06 E-value: 1.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 32 ALPAISSDLHKPAFEM-QMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGI 110
Cdd:cd17473 21 ALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 111 GGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHaSWHWIFLInipigalgilasgsvmnnikg 190
Cdd:cd17473 101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLV--------------------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 191 kaekldwtgfllFALGLVGITLGLDLLGESQHNSSVTYSilvvgilllvtycgYAKNNENAILPLSLFrtRTFRLGIIAN 270
Cdd:cd17473 159 ------------YLLALPVLILVLLFLPEPARKSKSAAS--------------PGAATAAALPWKRVL--PIYFLAFLAM 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 271 IFIrlsaSGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWldkQ 350
Cdd:cd17473 211 LLF----YVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL---A 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 351 SSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSivqqVGIGFGIAVSSIILNLYRHFFSAsdclpQAF 430
Cdd:cd17473 284 SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT----SAFFLGQFLSPLVLGPLVNLTGG-----LSG 354
|
410
....*....|....*....
gi 1176313 431 SYTFLTSSLFVIALVWSLM 449
Cdd:cd17473 355 AFLILGVLALVLAIVLLLL 373
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
32-189 |
2.64e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 64.94 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 32 ALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIG 111
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 112 GAfmmpvARLAIIQAV-----PKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLInipIGALGILASGSVMN 186
Cdd:PRK11102 93 AA-----AASVVINALmrdmfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV---LALAAILAAALVFF 164
|
...
gi 1176313 187 NIK 189
Cdd:PRK11102 165 FIP 167
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-417 |
1.51e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 62.61 E-value: 1.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 17 MALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAAS 96
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 97 NLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGAL 176
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 177 GILASGSVMNNIKGKAEkldwtgfllfalglvgitlgLDLLGESQHNSSVTYSILVVGILLLVTYCGYaknnenailpls 256
Cdd:cd17489 163 ALLLVFLVKDPPPVAAE--------------------EAEAGTRAFRRLVEKKVLPPALILFLASIAY------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 257 lfrtrtfrlGIIANiFIRLSASGVPFLLPLMFQLSFgysaemsgwllapiALISVMLKILIGRILNRWGYKTTLISSALL 336
Cdd:cd17489 211 ---------GAIST-FLPLYAAERGISNAGLFFTVY--------------AIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 337 MAgsvISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLY 416
Cdd:cd17489 267 LA---LGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF 343
|
.
gi 1176313 417 R 417
Cdd:cd17489 344 G 344
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
14-170 |
3.75e-10 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 61.12 E-value: 3.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 14 VAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACA 93
Cdd:cd17476 2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176313 94 AASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVN-AWNLMATAGLIGPILGPILGGWLVIHASWHWIFLIN 170
Cdd:cd17476 82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
27-416 |
9.96e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.94 E-value: 9.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 27 TILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFG-----TLTVFRSAVFTFILGSVACAAASNLESL 101
Cdd:cd06173 16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDrrrllILADLLRALLAAVLALLALLGSLSLWLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 102 ILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIpigalgilas 181
Cdd:cd06173 96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA---------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 182 gsvmnnikgkaekldwTGFLLFALGLVGITLGLDLlgESQHNSSVTYSILVVGILLLVtycgyaknnenailplslfRTR 261
Cdd:cd06173 166 ----------------LSFLLSALLLLFIRRPPPA--APGESSSLLLRDLREGLRYLR-------------------RSP 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 262 TFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSV 341
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176313 342 ISMAWLdkqSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLY 416
Cdd:cd06173 289 LVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
71-180 |
8.25e-09 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 57.26 E-value: 8.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 71 KFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILG 150
Cdd:PRK15402 74 RIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLG 153
|
90 100 110
....*....|....*....|....*....|
gi 1176313 151 PILGGWLVIHASWHWIFLInipIGALGILA 180
Cdd:PRK15402 154 PLVGAALIHVLPWRGMFVL---FAALAALS 180
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-169 |
1.03e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.98 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 14 VAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACA 93
Cdd:TIGR00895 21 LSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCA 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176313 94 AASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLI 169
Cdd:TIGR00895 101 LATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-180 |
2.35e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 2.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 9 RGLAWVAAMALFMQSLDATILNTALPAISSDLHK-PAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFIL 87
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 88 GSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIF 167
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|...
gi 1176313 168 LINIPIGALGILA 180
Cdd:cd17325 358 LAAAALLLLAAVL 370
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
17-181 |
1.11e-07 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 53.88 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 17 MALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAAS 96
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 97 NLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLInipIGAL 176
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFII---EGVL 157
|
....*
gi 1176313 177 GILAS 181
Cdd:TIGR00893 158 GIIWG 162
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
36-416 |
1.14e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.69 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 36 ISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFM 115
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 116 MPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHaSWHWIFLINIpigalgilasgsvmnnikgkaekl 195
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAA------------------------ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 196 dwTGFLLFALglvgitlgldllgesqhnssvtysILVVGILLLVTYCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRL 275
Cdd:cd17329 161 --VLFLLAAL------------------------VLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 276 SASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAgsvISMAWLDKQSSLTW 355
Cdd:cd17329 215 IYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFA---IGFAVLAFANTLAV 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176313 356 IICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLY 416
Cdd:cd17329 292 LILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL 352
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
256-446 |
1.15e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 256 SLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSAL 335
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 336 LMAGSVISMAWLDKQSSLTWIICNLMwYGACMSIIFTSINTL--AVGDLSKQQSGTGST-----VLSIVQQVGIGFGIAV 408
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWLLLVLAAL-AGIGLGAILVLPWAMlaDVVDYDEWKTGRRREglyfgIFTFAIKLGQALAGAL 381
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1176313 409 SSIILNLYrHFFSASDCLPQA-----FSYTFLTSSLFVIALVW 446
Cdd:COG2211 382 AGLLLALF-GYVAGAAQSPSAltgirLLFFLLPAVLLLLAALL 423
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
264-454 |
7.36e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.99 E-value: 7.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 264 RLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVIS 343
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 344 MAWLDkqsSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLYrhffsas 423
Cdd:cd17329 82 LGFAH---SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS------- 151
|
170 180 190
....*....|....*....|....*....|..
gi 1176313 424 dclpqaFSYTFL-TSSLFVIALVWSLMKLHKH 454
Cdd:cd17329 152 ------FRLLFLaAAVLFLLAALVLLFLLPET 177
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-378 |
7.99e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.95 E-value: 7.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 2 TTESNAYRGLAWVAAMALFMQSLDATI--LNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFR 79
Cdd:COG2807 8 ARRSRRAGRWLLLLAIVLVALNLRPAItsVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 80 SAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQ-LVNAwnLMATAGLIGPILGPILGGWLV 158
Cdd:COG2807 88 LALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVgLMTG--LYTAAMGLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 159 IHASWHWIFLInipigalgilasgsvmnnikgkaekldWTGFLLFAlglvgitlgldllgesqhnssvtysiLVVGILLL 238
Cdd:COG2807 166 AALGWRGALAV---------------------------WALLALLA--------------------------LLLWLPLL 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 239 VTYCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQlSFGYSAEMSGWLLAPIALISVMLKILIG 318
Cdd:COG2807 193 RRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVP 271
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176313 319 RILNRWGY-KTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLA 378
Cdd:COG2807 272 LLADRLGDrRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRA 332
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
81-185 |
8.46e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.58 E-value: 8.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 81 AVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIH 160
Cdd:cd17365 70 SVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPA 149
|
90 100
....*....|....*....|....*.
gi 1176313 161 ASWHWIFLIN-IPIGALGILASGSVM 185
Cdd:cd17365 150 FGWRSVFLLGgVPPLILLPLLRGTLL 175
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
13-302 |
9.45e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 47.68 E-value: 9.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 13 WVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVAC 92
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 93 AAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHAS----WHWIFL 168
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 169 INIPIGALGILASGSV-------MNNIKGKAEKLDWTGFLLFALGLVGITLGLDLL------------------GESQHN 223
Cdd:cd17371 162 LGALPALLVLFIRRFVkeppqwqAARAARRHFADRPSLRELFSPPLLRTTLLASLLatgalggyygittwlpsyLTGERG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 224 SSVTYSILVVGILLLVTYCGYAKnneNAILPLSLFRTRTFRLGIIANIFIRLSASGVPF----LLPLMFQLSFGYSAEMS 299
Cdd:cd17371 242 LSFEGSAGYLVVTILGGFLGYLA---GGFLADRIGRRNNFALFALGSAISILLYFFLPLsptlILILGFPLGFFASGPFS 318
|
...
gi 1176313 300 GWL 302
Cdd:cd17371 319 GMG 321
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
31-179 |
3.25e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 46.17 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 31 TALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGI 110
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176313 111 GGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFlinIPIGALGIL 179
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF---YTMAAMGIL 169
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
72-412 |
3.29e-05 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 46.15 E-value: 3.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 72 FGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMpvarlaIIQAVPKQQLVN-AWNLMATA-----GLI 145
Cdd:cd17322 64 FGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLN------LLLTLILADFSSlKNRGFASAipslpYII 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 146 GPILGPILGGWLVIHASWHW---IFLINIPIGALGILASGSVM-------NNIKGKAE-------------------KLD 196
Cdd:cd17322 138 TTWIGGNIAQAALPNSNWRWgygMWAIILPLSSLPLVLCLLYMqrkarkdGEIKELKNqeteeqtgglsqnlvklfwKLD 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 197 WTGFLLFALGLVGITLGLDLLGE--SQHNSSVTYSILVVGILLLVTYCGY-AKNNENAILPLSLFRTRTF--RLGIIANI 271
Cdd:cd17322 218 IFGVILLTAGLGLILVPLTLAGGakSKWKNSSIIAMIVLGGVLLVAFLLWeAKFAKYPFLPFRLLKDRTIlaACLIDFFY 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 272 FIRLSASGVPFLLPLmfQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTL--ISSALLMAGSVISMAWLDK 349
Cdd:cd17322 298 FFSYYIFSDYLYTVL--QVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLviIGVPLYIVGMGLLIRYRGG 375
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176313 350 QSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSII 412
Cdd:cd17322 376 SGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAI 438
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
8-263 |
3.46e-05 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 46.20 E-value: 3.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 8 YRGLAWVAAMALFMQSLDATIL-----NTALPAISSDLHKPAFEMQMAIIaYSLAVALFIPLTAWAAAKFGTLTVFRSAV 82
Cdd:pfam06609 37 YRSPRIIASFAAFSLNVCATYFvlqasASALPNILQDIGQSENQGLFSTL-WTMGQAVSILMMGRLTDRFGRRPFVIATH 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 83 FTFILGSVACAAASNLESLILARVIQGIG----GAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLigpilGPILGGWLV 158
Cdd:pfam06609 116 IIGLVGAIVGCTANKFNTLLAAMTLLGVAagpaGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGA-----GPYFGQRLA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 159 IHASWHWIFLINIPIGALGIL--------ASGSVMNNIKGKAE----KLDWTGFLLFALGLVGITLGLDLLGE--SQHNS 224
Cdd:pfam06609 191 IQGNWRWIFYIYIIMSAIAVLliiiwyhpPSFAQLHGKKARKRdelaKLDWIGIFLVIAGTSLFLLGVSWGGKpnNPWNS 270
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1176313 225 SVTYSILVVGILLLVTYCGYA--KNNENAILPLSLFR-TRTF 263
Cdd:pfam06609 271 AKIIGLISSGAGSLVIFALYEvfGKPEQPIIPPALFKdTRGF 312
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
14-167 |
3.47e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 45.72 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 14 VAAMALFMQSLDATILNTALPAISSDLHKPA--FEMQMAIIAYSLAVALFIPLTA-WAAAKFGTLTVFRSAVFTFILGSV 90
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVlsTGWQELIVSSTVAGAAVGAAIGgWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 91 ACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQ---QLVNAWNLMATAG-LIGPILGpilGGWLVIHASWHWI 166
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRirgRLVTINVLFITGGqFVAYVIN---GAFSYLPGGWRWM 157
|
.
gi 1176313 167 F 167
Cdd:cd17360 158 L 158
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-244 |
5.29e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 5.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 14 VAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIP--LTAWAAAKFGTLTVFRSAVFTFILGSVA 91
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGalLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 92 CAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHAS----WHWIF 167
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILF 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176313 168 LINIPIGALGILASGSVMnnikgkaekLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVTYCGY 244
Cdd:cd17316 163 LIGALPALLALLLRRRTL---------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGA 230
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-185 |
7.70e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 7.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 9 RGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILG 88
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 89 SVACAAA--SNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVN----------AWNLMATAGLigpILGPILGGW 156
Cdd:COG2211 308 LLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglyfgIFTFAIKLGQ---ALAGALAGL 384
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1176313 157 LVIHASW-----------HWIFLINIPIGALGILASGSVM 185
Cdd:COG2211 385 LLALFGYvagaaqspsalTGIRLLFFLLPAVLLLLAALLL 424
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
13-180 |
7.89e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.92 E-value: 7.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 13 WVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVAC 92
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 93 AAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHA-SWHWIFLIni 171
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRV-- 159
|
....*....
gi 1176313 172 pIGALGILA 180
Cdd:cd17328 160 -TGVLGVLL 167
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
66-179 |
8.21e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 8.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 66 AWAAAKFGTLTVFRSAVFTFILGSVAC--AAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAG 143
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATLLTplLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134
|
90 100 110
....*....|....*....|....*....|....*.
gi 1176313 144 LIGPILGPILGGWLVIHASWHWIFLInipIGALGIL 179
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFYF---FGLLGLL 167
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
55-179 |
1.25e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 55 SLAVALFIPLTA-WAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLV 133
Cdd:cd17474 244 SVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1176313 134 NAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGIL 179
Cdd:cd17474 324 TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
14-181 |
1.77e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.75 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 14 VAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFiplTAWAAAKFGTLTVFRSAVFT-FILGSVAC 92
Cdd:cd17490 199 FSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALA---SLLSGTLFYKKLGERNTIIIgFLLLGAYC 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 93 AA---ASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLI 169
Cdd:cd17490 276 FLipfAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFV 355
|
170
....*....|..
gi 1176313 170 nipIGALGILAS 181
Cdd:cd17490 356 ---IGVIALLAA 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
53-416 |
2.37e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.32 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 53 AYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQ- 131
Cdd:cd17477 39 AYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENr 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 132 -LVNAWNLMATAglIGPILGPILGGWLVIHAswHWIFLInipigalgilasgsvmnnikgkaekldwtGFLLFALGLVGI 210
Cdd:cd17477 119 gRVLGLYSTVLG--LGFALGPLLLALVGTAG--ALPFLI-----------------------------AAVLLLLALVPL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 211 TLGLDLLGESQHNSSVTYSILVvgilllvtycgyaknnenailplslfrtRTFRLGIIANIFIRLSASGVPFLLPLmFQL 290
Cdd:cd17477 166 LLTRRAAPEIEEAESISLRRLL----------------------------RIAPLALLGAFVAGFLEGAFYSLLPL-YGL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 291 SFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNLmwYGACMSII 370
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFL--WGGAAGPL 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1176313 371 FTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLY 416
Cdd:cd17477 295 YTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF 340
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
288-458 |
5.58e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.15 E-value: 5.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 288 FQLSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWLdkqSSLTWIICNLMWYGACM 367
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA---PSYPLLLLALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 368 SIIFTSINTLAvgdlSKQQSGTGSTVLSIVqQVGIGFGIAVSSIILNLyrhFFSASDCLPQAFSYTFLTSSLFVIALVWS 447
Cdd:COG0738 111 GLLDVAANPYV----AALGPETAASRLNLL-HAFFSLGALLGPLLGGL---LILLGLSLSWHLPYLILAVLLLLLALLFL 182
|
170
....*....|.
gi 1176313 448 LMKLHKHDGDH 458
Cdd:COG0738 183 RSKLPEIEEEE 193
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-180 |
6.77e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.78 E-value: 6.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 9 RGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILG 88
Cdd:COG2807 214 SPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 89 SVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMA-TAGLIGPILGPILGGWLV-IHASWHWI 166
Cdd:COG2807 294 GLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAqSVGYLLAALGPLLVGALHdATGSWTAA 373
|
170
....*....|....
gi 1176313 167 FLINIPIGALGILA 180
Cdd:COG2807 374 LLLLAALAVLMLVA 387
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
15-180 |
9.66e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.45 E-value: 9.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 15 AAMALFMQSLDATIlntalPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFrsAVFTFILGSVACAA 94
Cdd:cd17475 6 AAASLVAQGIPALA-----PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVL--AVGLLLMGAAALLM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 95 A--SNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLInip 172
Cdd:cd17475 79 AlvGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV--- 155
|
....*...
gi 1176313 173 IGALGILA 180
Cdd:cd17475 156 AGLVSILA 163
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
71-180 |
1.26e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 40.97 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 71 KFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILG 150
Cdd:PRK15403 77 RIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIG 156
|
90 100 110
....*....|....*....|....*....|
gi 1176313 151 PILGGWLVIHASWHWIFLInipIGALGILA 180
Cdd:PRK15403 157 PLSGAALMHFVHWKVLFAI---IAVMGLIA 183
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
52-182 |
1.60e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 52 IAYSLAVALFIPltaWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQ 131
Cdd:cd17330 221 IAGILAQLLLIP---RLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKE 297
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1176313 132 LVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILASG 182
Cdd:cd17330 298 QGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
31-157 |
1.75e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 40.43 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 31 TALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARViqGI 110
Cdd:pfam06779 214 TFLPAMARDGFGGPAAAALFWSLFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSL--LF 291
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1176313 111 GGAFMMPVAR-LAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWL 157
Cdd:pfam06779 292 GGTFMAITSLvMQLARELAPPAPRRLLGLMTASFGIGQILGPLLASLL 339
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
11-180 |
1.97e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.24 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 11 LAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSV 90
Cdd:cd17359 2 ISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 91 ACAAASNLESLILARVIQG--IGGAFMMPVARLAIIQAVPKQ-QLVNAWNLMATAGLIGP-----ILGPILGGWLVIHAS 162
Cdd:cd17359 82 GSAFSPNFTIFIIARIIGGlaVGGASALVPMYIAEVAPAEIRgRLVSLNQLMIVFGQLLAyivnyLIANAGGADWLGAEG 161
|
170
....*....|....*....
gi 1176313 163 WHWIFLIN-IPIGALGILA 180
Cdd:cd17359 162 WRWMLGLEaIPAILFLLGM 180
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-181 |
2.67e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 8 YRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAK-FGTLTVFRSAVFTFI 86
Cdd:cd06174 202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 87 LGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWL-VIHASWHW 165
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTG 361
|
170
....*....|....*.
gi 1176313 166 IFLINIPIGALGILAS 181
Cdd:cd06174 362 AFLVLAVLLLLAAILL 377
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
39-181 |
2.83e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 39 DLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAfMMPV 118
Cdd:cd17330 28 KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSV 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176313 119 ARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILAS 181
Cdd:cd17330 107 AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLV 169
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
27-168 |
3.31e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 39.51 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 27 TILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARV 106
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176313 107 IQGIGGAFMMPVARlaiiqAVPK-----QQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFL 168
Cdd:PRK11652 105 IQGLGTGVGGVMAR-----TLPRdlyegTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYL 166
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
256-416 |
3.52e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 256 SLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQlSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSAL 335
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 336 LMAGSVISMAWLDkqsSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNL 415
Cdd:COG2814 84 LFALGSLLCALAP---SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
.
gi 1176313 416 Y 416
Cdd:COG2814 161 F 161
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
14-111 |
3.74e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.48 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 14 VAAMALFMQSLDATILNTALPAISSDLHKPAF-EMQMAIIAYSLAVALFIPLTA-WAAAKFGTLTVFRSAVFTFILGSVA 91
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLStSLQGLVVSSLLLGAAIGSLFGgPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100
....*....|....*....|
gi 1176313 92 CAAASNLESLILARVIQGIG 111
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLG 100
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
29-167 |
4.77e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.28 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 29 LNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQ 108
Cdd:TIGR00881 14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 109 GIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGP-ILGGWLVIHASWHWIF 167
Cdd:TIGR00881 94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVF 153
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-361 |
5.85e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 12 AWVAAMALFMQSLDATILNTA---LPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILG 88
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFgvfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 89 SVACAAASNLESLILAR-VIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIF 167
Cdd:cd17355 82 LVLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 168 LInipigalgilasgsvmnnikgkaekldwTGFLLFALGLVGITLGLDLLGESQHNSSVTysilvvgilllvtycgyAKN 247
Cdd:cd17355 162 LV----------------------------LALLALLVLVPVLLLLRRRPADLALRAYDD-----------------ASP 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 248 NENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQlSFGYSAEMSGWLLAPIALISVMLKILIGRILNRWGYK 327
Cdd:cd17355 197 ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR 275
|
330 340 350
....*....|....*....|....*....|....
gi 1176313 328 TTLISSALLMAGSVISMAWLDKQSSLTWIICNLM 361
Cdd:cd17355 276 RLLAASYALRALGLALLLLLPFPPLALLLFAALF 309
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
33-180 |
6.86e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 38.54 E-value: 6.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 33 LPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGG 112
Cdd:PRK10091 26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPH 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176313 113 AFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILA 180
Cdd:PRK10091 106 GAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLAS 173
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
261-389 |
8.34e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.35 E-value: 8.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 261 RTFRLGIIANIFIRLSASGVPFLLPL-MFQL----SFGYSAEMSGWLLAPIALIS-VMLKILIGRILNRWGYKTTLISSA 334
Cdd:cd17331 202 RLLRLPGVAFLLLVKLLSGLPIGMFQsMFSLvamdFFGLTPEENGYLMSYAGVLGmVVQGLLVGPLTKRFGERSLLKLSV 281
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1176313 335 LLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVgdlSKQQSGT 389
Cdd:cd17331 282 ALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAV---PPEDTGT 333
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
13-155 |
8.66e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 8.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176313 13 WVAAMALFMQSLDATILNTALPAISSDLHKPAF---EMQMAII--AYSLAVALFIPLTAWAAAKFGTLTVFRSAVFTFIL 87
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLPTPTGFglgITEAGLLllPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176313 88 GSVACAA-ASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGG 155
Cdd:cd17504 260 GLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328
|
|
| |
