|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
76-721 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 1006.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 76 GALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 155
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 156 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 235
Cdd:TIGR01787 80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 236 VYLPMSYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQR 314
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 315 AVQKLYEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQ 394
Cdd:TIGR01787 232 ALQWLYEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 395 ALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcp 472
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE--- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 473 hvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHR 552
Cdd:TIGR01787 382 --DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHR 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 553 AAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGED 632
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 633 FESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIF 711
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611
|
650
....*....|
gi 1352387 712 PIWALGRFSQ 721
Cdd:TIGR01787 612 PLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
77-719 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 939.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 77 ALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTAL 156
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 157 NYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQV 236
Cdd:cd02892 81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 237 YLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPdeLYTPHSWLLRVVYALLNLYEHHHSAHLRQRAV 316
Cdd:cd02892 161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 317 QKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQAL 396
Cdd:cd02892 239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 397 LEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHvTE 476
Cdd:cd02892 319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 477 HIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRaAEI 556
Cdd:cd02892 396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 557 RETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESC 636
Cdd:cd02892 475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 637 EERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWAL 716
Cdd:cd02892 552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631
|
...
gi 1352387 717 GRF 719
Cdd:cd02892 632 GRY 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
32-724 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 593.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 32 GRQTWTYLQD-----ERAGREQTGLEAY---------------ALGLDTKNYFKDLPKA------HTAFEGALN----GM 81
Cdd:PLN03012 24 GRQTWEFDPDagspeELAAVEEARRIFYddrfhvkassdliwrMQFLKEKKFEQRIAPAkvedaeKITFEIATNalrkGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 82 TFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALN 157
Cdd:PLN03012 104 HFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLN 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 158 YVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCR 234
Cdd:PLN03012 183 YICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPIHPAKMWCYCR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 235 QVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH---- 310
Cdd:PLN03012 263 LVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFAEPFLACwpfn 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 311 --LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIWD 388
Cdd:PLN03012 343 klLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKMQ-SFGSQLWD 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 389 TAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLL 467
Cdd:PLN03012 421 SGFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCTAEGFKCCLLF 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 468 QEKCPH-VTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHK 546
Cdd:PLN03012 499 SMIAPDiVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQ 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 547 RFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMAD 626
Cdd:PLN03012 579 LYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGVHFLLAAQKDN 655
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 627 GGWGEDFESCEERRYLQSA--QSQIHNTCWAMMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSC 700
Cdd:PLN03012 656 GGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQEATGAFLKNC 733
|
730 740
....*....|....*....|....
gi 1352387 701 AISYTSYRNIFPIWALGRFSQLYP 724
Cdd:PLN03012 734 LLHYAAYRNIFPLWALAEYRARVP 757
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
71-723 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 562.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 71 HTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKST 150
Cdd:COG1657 18 RSLLDAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 151 VFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLW 230
Cdd:COG1657 98 LSTTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 231 CHCRQVYLPMSYCYAVRLSAAEDPLVqsLRQELYVEDFASIDWLAQRNNVApdelyTPHSWLLRVVYALLNLYEHHHSAH 310
Cdd:COG1657 178 YWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPRDR-----SPWSRFFLALDRLLRAYERLPPKP 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 311 LRQRAVQKLYEHIvaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQI 386
Cdd:COG1657 251 LRRRALRKAEDWI--LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 387 WDTAFAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLL 466
Cdd:COG1657 327 WDTALAVQALQEAG---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLR 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 467 LQekcpHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKyfhk 546
Cdd:COG1657 403 LR----LPDEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLG---- 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 547 rfpEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMAD 626
Cdd:COG1657 473 ---QLGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNAD 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 627 GGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYT 705
Cdd:COG1657 546 GGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYH 625
|
650
....*....|....*...
gi 1352387 706 SYRNIFPIWALGRFSQLY 723
Cdd:COG1657 626 LYRQYFPLWALARYRNLR 643
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
384-719 |
1.46e-50 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 179.45 E-value: 1.46e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 384 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 463
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 464 vlLLQEKCPHVTEhiPRERLCDAVAVLLNMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 539
Cdd:pfam13243 78 --LDRVRLPDERR--RDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 540 ALKYFHkrFPEHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 619
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 620 LSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNK 698
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
|
330 340
....*....|....*....|.
gi 1352387 699 SCAISYTSYRNIFPIWALGRF 719
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
76-721 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 1006.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 76 GALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 155
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 156 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 235
Cdd:TIGR01787 80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 236 VYLPMSYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQR 314
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 315 AVQKLYEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQ 394
Cdd:TIGR01787 232 ALQWLYEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 395 ALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcp 472
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE--- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 473 hvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHR 552
Cdd:TIGR01787 382 --DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHR 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 553 AAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGED 632
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 633 FESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIF 711
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611
|
650
....*....|
gi 1352387 712 PIWALGRFSQ 721
Cdd:TIGR01787 612 PLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
77-719 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 939.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 77 ALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTAL 156
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 157 NYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQV 236
Cdd:cd02892 81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 237 YLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPdeLYTPHSWLLRVVYALLNLYEHHHSAHLRQRAV 316
Cdd:cd02892 161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 317 QKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQAL 396
Cdd:cd02892 239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 397 LEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHvTE 476
Cdd:cd02892 319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 477 HIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRaAEI 556
Cdd:cd02892 396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 557 RETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESC 636
Cdd:cd02892 475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 637 EERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWAL 716
Cdd:cd02892 552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631
|
...
gi 1352387 717 GRF 719
Cdd:cd02892 632 GRY 634
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
87-719 |
0e+00 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 615.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 87 LQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGV 166
Cdd:TIGR03463 4 LQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPDAEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALRLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 167 GPDDPDLVRARNILH-KKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYA 245
Cdd:TIGR03463 84 GKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGIAWLSG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 246 VRLSAAE-DPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIV 324
Cdd:TIGR03463 164 RGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYERLAGKALRARALDFAFEQIL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 325 ADDRFTKSISIGPISKTINMLVrWYVDGPASTAFQEHVSRIPDYLWMGLD-GMKMQGTNGSQIWDTAFAIQALLEAG--- 400
Cdd:TIGR03463 244 AEDEATHYICIGPINGLLNCLA-IFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSNALWDTAFAVQALAALGeld 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 401 GHHRpefsSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEK-CPHVTEHIP 479
Cdd:TIGR03463 323 EEAK----HALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELgDNRISEALG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 480 RERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRET 559
Cdd:TIGR03463 399 AARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAA 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 560 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 639
Cdd:TIGR03463 479 IRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPAD----MALQAAAAFLLEKQRADGAWGEHVESCLEA 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 640 RYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRF 719
Cdd:TIGR03463 555 RWVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
32-724 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 593.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 32 GRQTWTYLQD-----ERAGREQTGLEAY---------------ALGLDTKNYFKDLPKA------HTAFEGALN----GM 81
Cdd:PLN03012 24 GRQTWEFDPDagspeELAAVEEARRIFYddrfhvkassdliwrMQFLKEKKFEQRIAPAkvedaeKITFEIATNalrkGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 82 TFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALN 157
Cdd:PLN03012 104 HFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLN 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 158 YVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCR 234
Cdd:PLN03012 183 YICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPIHPAKMWCYCR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 235 QVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH---- 310
Cdd:PLN03012 263 LVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFAEPFLACwpfn 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 311 --LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIWD 388
Cdd:PLN03012 343 klLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKMQ-SFGSQLWD 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 389 TAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLL 467
Cdd:PLN03012 421 SGFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCTAEGFKCCLLF 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 468 QEKCPH-VTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHK 546
Cdd:PLN03012 499 SMIAPDiVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQ 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 547 RFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMAD 626
Cdd:PLN03012 579 LYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGVHFLLAAQKDN 655
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 627 GGWGEDFESCEERRYLQSA--QSQIHNTCWAMMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSC 700
Cdd:PLN03012 656 GGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQEATGAFLKNC 733
|
730 740
....*....|....*....|....
gi 1352387 701 AISYTSYRNIFPIWALGRFSQLYP 724
Cdd:PLN03012 734 LLHYAAYRNIFPLWALAEYRARVP 757
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
71-723 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 562.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 71 HTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKST 150
Cdd:COG1657 18 RSLLDAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 151 VFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLW 230
Cdd:COG1657 98 LSTTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 231 CHCRQVYLPMSYCYAVRLSAAEDPLVqsLRQELYVEDFASIDWLAQRNNVApdelyTPHSWLLRVVYALLNLYEHHHSAH 310
Cdd:COG1657 178 YWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPRDR-----SPWSRFFLALDRLLRAYERLPPKP 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 311 LRQRAVQKLYEHIvaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQI 386
Cdd:COG1657 251 LRRRALRKAEDWI--LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 387 WDTAFAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLL 466
Cdd:COG1657 327 WDTALAVQALQEAG---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLR 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 467 LQekcpHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKyfhk 546
Cdd:COG1657 403 LR----LPDEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLG---- 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 547 rfpEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMAD 626
Cdd:COG1657 473 ---QLGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNAD 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 627 GGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYT 705
Cdd:COG1657 546 GGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYH 625
|
650
....*....|....*...
gi 1352387 706 SYRNIFPIWALGRFSQLY 723
Cdd:COG1657 626 LYRQYFPLWALARYRNLR 643
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
80-719 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 562.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 80 GMTFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 155
Cdd:PLN02993 102 GVSFFSALQASDGHWpgeiTGPLFFLPPLVFCLYITGHLEEV-FDAEHRKEMLRHIYCHQNEDGGWGLHIESKSVMFCTV 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 156 LNYVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCH 232
Cdd:PLN02993 181 LNYICLRMLGEGPNggrENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMPPEIWLLPSFLPIHLGKTLCY 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 233 CRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH-- 310
Cdd:PLN02993 261 TRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLVQDLIWDTLHNFVEPFLTRwp 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 311 ----LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQI 386
Cdd:PLN02993 341 lnklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDHFKKHLARIPDYMWVAEDGMKMQ-SFGSQL 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 387 WDTAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVL 465
Cdd:PLN02993 419 WDTGFAIQALLAS--DLSDETDDVLRRGHNYIKKSQVRENPSgDFKSMYRHISKGAWTLSDRDHGWQVSDCTAEALKCCM 496
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 466 LLQEKCPHVT-EHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYF 544
Cdd:PLN02993 497 LLSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVEREYVECTSAVIQALVLF 576
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 545 HKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQM 624
Cdd:PLN02993 577 KQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYND---CLAMRKGVHFLLTIQR 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 625 ADGGWGEDFESCEERRY--LQSAQSQIHNTCWAMMGLMAVRHP--DIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSC 700
Cdd:PLN02993 654 DDGGWGESYLSCPEQRYipLEGNRSNLVQTAWAMMGLIHAGQAerDLIPLHRAAKLIITSQLENGDFPQQEILGAFMNTC 733
|
650
....*....|....*....
gi 1352387 701 AISYTSYRNIFPIWALGRF 719
Cdd:PLN02993 734 MLHYATYRNTFPLWALAEY 752
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
384-719 |
2.49e-174 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 502.52 E-value: 2.49e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 384 SQIWDTAFAIQALLEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 463
Cdd:cd02889 23 SQVWDTALALQALLEAGLA--PEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 464 VLLLQEKCPHvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELlnPSEVFGDIMIDYTYVECTSAVMQALKY 543
Cdd:cd02889 101 LLRLQKKPPD-GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 544 FHKRFPEHRAaEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRdgtaCAEVSRACDFLLSRQ 623
Cdd:cd02889 178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGEDEN----SPYVRKACDWLLSKQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 624 MADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAIS 703
Cdd:cd02889 253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332
|
330
....*....|....*.
gi 1352387 704 YTSYRNIFPIWALGRF 719
Cdd:cd02889 333 YHNYRNYFPLWALGRY 348
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
83-722 |
2.01e-62 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 220.53 E-value: 2.01e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 83 FYVGLQAEDGHWTGDYGGPLFLLPGLLITCH----VARIPLpagyrEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNY 158
Cdd:TIGR01507 24 YLLSCQKDEGYWWGELESNVTIEAEYVLLCHildrVDRDRM-----EKIRNYLLHEQREDGTWALYPGGPGDLSTTVEAY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 159 VSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYL 238
Cdd:TIGR01507 99 VALKYIGMSRDEPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEFSSWARATVV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 239 PMSYCYAVRLSAaedPLVQSLR-QELYVEDfasidwlaqrnnVAPDELYTPHS---W-LLRVVYALLNLYEHHHSAHLRQ 313
Cdd:TIGR01507 179 PLSIVCSRKPVF---PLPERARvPELYETD------------VPKPRRRGAKGgtgWgIFDALDRALHGYEKLSVHPFRR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 314 RAVQKLYEHIVAddRFTKSISIGPISKT-INMLVRWYVDG-PASTAF-QEHVSRIPDYLWMGLDGMKMQGTNgSQIWDTA 390
Cdd:TIGR01507 244 AAEIRALDWLLE--RQAGDGSWGGIQPAmFNALIALKILGmTQHDAFiKLGWEGIDLYGVELDDSWMFQACV-SPVWDTA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 391 FAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVpDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEK 470
Cdd:TIGR01507 321 LAVLALREAG---LPADHDALVKAGEWLLDKQI-TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDDTAVVVWALNGLRLP 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 471 cphvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNpsevFGDI--MIDYTYVECTSAVMQALKYFHKRF 548
Cdd:TIGR01507 397 ----DERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGYDD 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 549 PehraaeiRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGG 628
Cdd:TIGR01507 469 A-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGIDTRE----PYIQKALAWLESHQNPDGG 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 629 WGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYTSY 707
Cdd:TIGR01507 538 WGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHMY 617
|
650
....*....|....*
gi 1352387 708 RNIFPIWALGRFSQL 722
Cdd:TIGR01507 618 RHVFPLLALARYKQA 632
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
374-719 |
4.22e-56 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 193.92 E-value: 4.22e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 374 DGMKMQGTNGSQIWDTAFAIQALLEAGGH--HRPEFSSCLQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSFSTLDcGW 451
Cdd:cd00688 15 DGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLSD--------------GGFSGWGGN-DY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 452 IVSDCTAEALKAVLLLQEkcphvTEHIPRERLCDAVAVLLNMRNPDGGFATYEtkrgghllellnpsEVFGDIMIDYTYV 531
Cdd:cd00688 80 PSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDG--------------PGNHRIGGDESDV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 532 ECTSAVMQALKYFHKRFPehraaeiRETLTQGLEFCRRQQRADGSWeGSWGVCFTYGTWFGLEAFACMGQTYRDgtacaE 611
Cdd:cd00688 141 RLTAYALIALALLGKLDP-------DPLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALALLGDLDSP-----D 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 612 VSRACDFLLSRQMADGGWGedfesceERRYLQSAQSQIHNTCWAMMGLMA-VRHPDIEAQERGVRCLLEKQLPNGDWPQE 690
Cdd:cd00688 208 AKKALRWLLSRQRPDGGWG-------EGRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVKWLLSQQNEDGGFSSK 280
|
330 340
....*....|....*....|....*....
gi 1352387 691 NIagvfnkscaISYTSYRNIFPIWALGRF 719
Cdd:cd00688 281 PG---------KSYDTQHTVFALLALSLY 300
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
384-719 |
1.46e-50 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 179.45 E-value: 1.46e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 384 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 463
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 464 vlLLQEKCPHVTEhiPRERLCDAVAVLLNMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 539
Cdd:pfam13243 78 --LDRVRLPDERR--RDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 540 ALKYFHkrFPEHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 619
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 620 LSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNK 698
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
|
330 340
....*....|....*....|.
gi 1352387 699 SCAISYTSYRNIFPIWALGRF 719
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
86-325 |
6.33e-41 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 151.48 E-value: 6.33e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 86 GLQAEDGHWTGD----------YggplfllpgllITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 155
Cdd:pfam13249 10 SLQHPDGHWVGEleanvtitaeY-----------ILLRHFLGPDDPELEAKIARYLRSQQREDGGWPLFHGGPGDLSTTV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 156 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 235
Cdd:pfam13249 79 EAYFALKLLGDSPDAPHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFNIYKFSSWART 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 236 VYLPMSYCYAVRLSAAEDPlvQSLRQELYVEDFASIDWlaqrnnvaPDELYTPHSW--LLRVVYALLNLYEHHHSAHLRQ 313
Cdd:pfam13249 159 TIVPLLILSALKPVAPLPP--GIGLDELFVEPPENVRY--------YPRPHRLFSWtnLFLGLDRVLKLYERLPPKPLRR 228
|
250
....*....|..
gi 1352387 314 RAVQKLYEHIVA 325
Cdd:pfam13249 229 RALRKAEEWILE 240
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
131-719 |
5.82e-19 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 91.23 E-value: 5.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 131 LRSVQLPDGGWgLHIEDKSTVFG----TALNYVSLRILGVGPD-DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSW 205
Cdd:TIGR04277 77 LLGSQFEDGSW-EQVEDANIETGqldaTIFNYWYLKAIGIDIHiDAALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPW 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 206 EGLntLFPEMWLFPDWAPAHPSTLWCHCRQ-VYLPMSYCYAVRLSAAEDPLVQSLRQELYvedfasIDWLAQRNNVAPDE 284
Cdd:TIGR04277 156 EDL--FKIPLFIFKKKGIFKPLYIKDITAQwVYPHLTALAYLQNQRIIFNVAVADIRELW------INKAKKGIKHQKKE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 285 LYT--PHSWLLRVVYALLNLYEHHHSahLRQRAVQKLYEHIVADDrFTksisigpiSKTINMlvrwyvdgpastafqeHV 362
Cdd:TIGR04277 228 RPSffIDNDLLILMDEIFKLKQPLGS--FGAYTISTLLSLLAFKD-FQ--------GKHPHK----------------HK 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 363 SRIPDYLWMGLDGMKM------QGTNGS----QIWDTAFAIQALLEAGGHH---RPEFSSCLQKAHEflrlsqvPDNPPD 429
Cdd:TIGR04277 281 NEIQDALEDGLDFVEFnyfnfrEAYHGSlddgRWWDTILISWAMLESGEDKekiFPIVENMLKEGLQ-------PKGGIE 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 430 YQKYYrqmrkgGFSFSTLDCGwivsdctaealkavLLLQEKCPHVTEHipRERLCDAVAVLLNMRNPDGGFATYET-KRG 508
Cdd:TIGR04277 354 YGYDF------EYAPDADDTG--------------LLLQVLSYYGEAF--ADAIDEGAEFLFSMQNDDGGFPAFDKgKME 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 509 GHLL--------ELLNPSEVFgdimiDYTYVECTSAVMQALKYFHKRfPEHraaeirETLTQGLEFCRRQQRADGSWEGS 580
Cdd:TIGR04277 412 DNLLfkfafkiaGIADSAEIF-----DPSCPDITAHILEGLGEFGDQ-ANH------DQIQKMIKYFMDTQEKFGSWEAR 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 581 WGVCFTYGTWFGLEAFACMGQTYRDGTacaeVSRACDFLLSRQMADGGWGEDFESCEE-RRYLQSAQSQIHNTCWAMMGL 659
Cdd:TIGR04277 480 WGINYIMAAGAVLPALAKMNYDLNEGW----AKNAINWLLNKQNADGGFGECTLSYNDpEKWNGIGKSTVTQTSWGLLAL 555
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1352387 660 MAVR-HPDI--EAQERGVRCLLEK-QLPNGDWPQENIAGVFNKSCA-ISYTSYRNIFPIWALGRF 719
Cdd:TIGR04277 556 LAVEdHNDQikEAADKAAQYLLDQfKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIALGRF 620
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
124-165 |
6.39e-10 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 54.82 E-value: 6.39e-10
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1352387 124 REEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILG 165
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
490-685 |
5.95e-08 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 54.71 E-value: 5.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 490 LLNMRNPDGGFATYETkrgghllellnPSEVFgdimidYTYVECTSAVMQALKYFHkrfpEHRAAEIRETLtqglefcrr 569
Cdd:COG5029 28 LRASQNPDGGFAGRSG-----------PSDLY------STYYAVRTLALLGESPKW----RDRVADLLSSL--------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 570 qQRADGSW----EGSWGvcFTYGTWFGLEAFACMGQTYRDgtacaeVSRACDFLLSRQMADGGWGEDFesceerrylqSA 645
Cdd:COG5029 78 -RVEDGGFakapEGGAG--STYHTYLATLLAELLGRPPPD------PDRLVRFLISQQNDDGGFEISP----------GR 138
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1352387 646 QSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNG 685
Cdd:COG5029 139 RSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
564-600 |
3.50e-07 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 47.12 E-value: 3.50e-07
10 20 30
....*....|....*....|....*....|....*...
gi 1352387 564 LEFCRRQQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 600
Cdd:pfam00432 7 VDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
120-180 |
4.09e-06 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 48.93 E-value: 4.09e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352387 120 PAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGpDDPDLVRARNIL 180
Cdd:COG5029 111 PPPDPDRLVRFLISQQNDDGGFEISPGRRSDTNPTAAAIGALRALGAL-DDPIETKVIRFL 170
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
612-658 |
1.65e-05 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 42.50 E-value: 1.65e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1352387 612 VSRACDFLLSRQMADGGWGEDFESCeerryLQSAQSQIHNTCWAMMG 658
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
411-660 |
3.25e-03 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 40.09 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 411 LQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSF-----STLdcgwivSDcTAEALKAVLLLQEKCPHVTEHIprerlcd 485
Cdd:COG1689 8 LARTIEYVLKRQNED--------------GGFCAypglpSTL------AD-TYYAVRILKLLGEEVPNRDKTI------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 486 avAVLLNMRNPDGG-FATYETKRGGHLLELLnpsevfGDIMIDYtyvectsavMQALKYFHKRFPEHRAAE---IRET-- 559
Cdd:COG1689 60 --EFLESCQDEEGGgFALYTTSYGLMALALL------GIDPPDE---------QEALEYLSDALPTKFAGGasdLEETyl 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 560 LTQGLE--------------FCRRQQRADGSWEGSWGVcfTYGTWFGLEAFACMGQTYRDGtacaevSRACDFLLSRQMA 625
Cdd:COG1689 123 AVALLEalgaseperekireFLLSLRRPDGGFGGKKPN--LEDTYWALAALRRLGRDLPPA------DRVIAFILACQNE 194
|
250 260 270
....*....|....*....|....*....|....*
gi 1352387 626 DGGWGedfesceerrYLQSAQSQIHNTCWAMMGLM 660
Cdd:COG1689 195 DGGFS----------KTPGSYSDLEATYYALRALK 219
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
388-576 |
5.40e-03 |
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Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 39.32 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 388 DTAFAIQALLEAGG-------------HHRPEFSSCLQKAHEFLR---LSQVPDNPPDYQK---YYR-----QMRKGGFS 443
Cdd:COG1689 37 DTYYAVRILKLLGEevpnrdktiefleSCQDEEGGGFALYTTSYGlmaLALLGIDPPDEQEaleYLSdalptKFAGGASD 116
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352387 444 FSTLDCgwivsdcTAEALKAVLLLQEKCPhvtehiprerlcDAVAVLLNMRNPDGGFA-----TYETkrgGHLLELL--- 515
Cdd:COG1689 117 LEETYL-------AVALLEALGASEPERE------------KIREFLLSLRRPDGGFGgkkpnLEDT---YWALAALrrl 174
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170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1352387 516 -----NPSEV-------------FGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAeiretltqgLEFCRRQQRADGS 576
Cdd:COG1689 175 grdlpPADRViafilacqnedggFSKTPGSYSDLEATYYALRALKLLGEPPKNVDKL---------LEFIASCQNSDGG 244
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| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
614-687 |
7.68e-03 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 39.13 E-value: 7.68e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352387 614 RACDFLLSRQMADGGWGEDFesceerrylqsaqSQIHNTCWAMMGLMA--VRHPDIEAQERGVRCLLEKQLP-NGDW 687
Cdd:cd02889 3 RALDFLLSLQAPDGHWPGEY-------------SQVWDTALALQALLEagLAPEFDPALKKALEWLLKSQIRdNPDD 66
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