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Conserved domains on  [gi|1709587|sp|P50580|]
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RecName: Full=Proliferation-associated protein 2G4; AltName: Full=IRES-specific cellular trans-acting factor 45 kDa; Short=ITAF45; AltName: Full=Mpp1; AltName: Full=Proliferation-associated protein 1; AltName: Full=Protein p38-2G4

Protein Classification

M24 family metallopeptidase; aminopeptidase P family protein( domain architecture ID 10794573)

M24 family metallopeptidase cleaves amido-, imido-, or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes| aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


:

Pssm-ID: 273105  Cd Length: 390  Bit Score: 643.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587      1 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587     79 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    159 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    319 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTVENATSGETLE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 643.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587      1 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587     79 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    159 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    319 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTVENATSGETLE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 18-334 3.01e-118

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 342.77  E-value: 3.01e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   18 VTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQD 97
Cdd:cd01089   1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   98 YILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSF 177
Cdd:cd01089  81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587  178 NCTPIEGMLSHQLKQhvidgektiiqnptdqqkkdhekaefevhevyavdvLVSSGEGKAKdagqrttiykrdpskqygl 257
Cdd:cd01089 161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1709587  258 kmktsraffseverrfdampftlrafedekkarmgVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT 334
Cdd:cd01089 186 -----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 62-329 1.35e-19

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 90.16  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    62 KIFKKEKEM------KKGIAFPTSISVNNCVCHFSPLKSDqDYILKEGDLVKIDLGVHVDGFIANVAHT---------FV 126
Cdd:PTZ00053 191 RIESKSRELieadglKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDCAFTvafnpkydpLL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   127 IGVAQGTQvTGrkadvIKAAHLCAeaalRLVKPGNQNTQVTEAW-----NKVahsFNCTPIEGMLSHQLKQHVIDGEKTI 201
Cdd:PTZ00053 270 QATKDATN-TG-----IKEAGIDV----RLSDIGAAIQEVIESYeveikGKT---YPIKSIRNLNGHSIGPYIIHGGKSV 336

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   202 -IQNPTDQQKkdhekaeFEVHEVYAVDVLVSSGEGKAKDAGQrTTIYKRDPSKQY-GLKMKTSRAFFSEVERRFDAMPFT 279
Cdd:PTZ00053 337 pIVKGGENTR-------MEEGELFAIETFASTGRGYVNEDLE-CSHYMKDPGAEFvPLRLPKAKQLLKHINTNFGTLAFC 408

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 1709587   280 LRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:PTZ00053 409 RRWLDRlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 25-174 2.66e-15

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 74.20  E-value: 2.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587     25 GDIANRVLRSLVEAsssgvsvlslCEKG------DAMIMEetgkiFKKEKEMKKGIAFPTSI--SVNNCVCHFSPLksdq 96
Cdd:pfam00557   7 ARIAAAALEAALAA----------IRPGvterelAAELEA-----ARLRRGGARGPAFPPIVasGPNAAIPHYIPN---- 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1709587     97 DYILKEGDLVKIDLGVHVD-GFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVA 174
Cdd:pfam00557  68 DRVLKPGDLVLIDVGAEYDgGYCSDITRTFVVG-----KPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL 141
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
76-188 3.19e-15

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 74.66  E-value: 3.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAA 153
Cdd:COG0024  62 FPKSIctSVNEVVVHGIP----SDRVLKDGDIVNIDVGAILDGYHGDSARTFVVG-----EVSPEARRLVEVTEEALYAG 132

                        90       100       110
                ....*....|....*....|....*....|....*
gi 1709587  154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:COG0024 133 IAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGH 167
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 643.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587      1 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587     79 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    159 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    319 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTVENATSGETLE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 18-334 3.01e-118

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 342.77  E-value: 3.01e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   18 VTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQD 97
Cdd:cd01089   1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   98 YILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSF 177
Cdd:cd01089  81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587  178 NCTPIEGMLSHQLKQhvidgektiiqnptdqqkkdhekaefevhevyavdvLVSSGEGKAKdagqrttiykrdpskqygl 257
Cdd:cd01089 161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1709587  258 kmktsraffseverrfdampftlrafedekkarmgVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT 334
Cdd:cd01089 186 -----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 20-329 4.13e-45

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 157.41  E-value: 4.13e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   20 KYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGkifkkekemkkGIAFPTSISVNNCVCHFSPLKSDqDYI 99
Cdd:cd01088   3 KYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGA-----------GPAFPVNLSINECAAHYTPNAGD-DTV 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587  100 LKEGDLVKIDLGVHVDGFIANVAHTfvigVAQGTQVTgrkaDVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNC 179
Cdd:cd01088  71 LKEGDVVKLDFGAHVDGYIADSAFT----VDFDPKYD----DLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGF 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587  180 TPIEGMLSHQLKQHVIDGEKTIiqnPTDqqkKDHEKAEFEVHEVYAVDVLVSSGEGKAKDaGQRTTIYKRDPSKQYGLKM 259
Cdd:cd01088 143 KPIRNLTGHSIERYRLHAGKSI---PNV---KGGEGTRLEEGDVYAIEPFATTGKGYVHD-GPECSIYMLNRDKPLRLPR 215

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1709587  260 ktSRAFFSEVERRFDAMPFTLRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:cd01088 216 --ARKLLDVIYENFGTLPFARRWLDRlgETKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDG 285
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 62-329 1.35e-19

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 90.16  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    62 KIFKKEKEM------KKGIAFPTSISVNNCVCHFSPLKSDqDYILKEGDLVKIDLGVHVDGFIANVAHT---------FV 126
Cdd:PTZ00053 191 RIESKSRELieadglKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDCAFTvafnpkydpLL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   127 IGVAQGTQvTGrkadvIKAAHLCAeaalRLVKPGNQNTQVTEAW-----NKVahsFNCTPIEGMLSHQLKQHVIDGEKTI 201
Cdd:PTZ00053 270 QATKDATN-TG-----IKEAGIDV----RLSDIGAAIQEVIESYeveikGKT---YPIKSIRNLNGHSIGPYIIHGGKSV 336

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   202 -IQNPTDQQKkdhekaeFEVHEVYAVDVLVSSGEGKAKDAGQrTTIYKRDPSKQY-GLKMKTSRAFFSEVERRFDAMPFT 279
Cdd:PTZ00053 337 pIVKGGENTR-------MEEGELFAIETFASTGRGYVNEDLE-CSHYMKDPGAEFvPLRLPKAKQLLKHINTNFGTLAFC 408

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 1709587   280 LRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:PTZ00053 409 RRWLDRlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 76-188 2.73e-18

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 83.31  E-value: 2.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAA 153
Cdd:cd01086  54 FPKSIctSVNEVVCHGIP----DDRVLKDGDIVNIDVGVELDGYHGDSARTFIVG-----EVSEEAKKLVEVTEEALYKG 124

                        90       100       110
                ....*....|....*....|....*....|....*
gi 1709587  154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:cd01086 125 IEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGH 159
PRK05716 PRK05716
methionine aminopeptidase; Validated
 76-188 6.10e-17

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 79.79  E-value: 6.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAA 153
Cdd:PRK05716  64 FPKSIctSVNEVVCHGIP----SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVG-----EISPEDKRLCEVTKEALYLG 134

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 1709587   154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:PRK05716 135 IAAVKPGARLGDIGHAIQKYAEAEGFSVVREYCGH 169
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 25-174 2.66e-15

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 74.20  E-value: 2.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587     25 GDIANRVLRSLVEAsssgvsvlslCEKG------DAMIMEetgkiFKKEKEMKKGIAFPTSI--SVNNCVCHFSPLksdq 96
Cdd:pfam00557   7 ARIAAAALEAALAA----------IRPGvterelAAELEA-----ARLRRGGARGPAFPPIVasGPNAAIPHYIPN---- 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1709587     97 DYILKEGDLVKIDLGVHVD-GFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVA 174
Cdd:pfam00557  68 DRVLKPGDLVLIDVGAEYDgGYCSDITRTFVVG-----KPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL 141
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
76-188 3.19e-15

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 74.66  E-value: 3.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAA 153
Cdd:COG0024  62 FPKSIctSVNEVVVHGIP----SDRVLKDGDIVNIDVGAILDGYHGDSARTFVVG-----EVSPEARRLVEVTEEALYAG 132

                        90       100       110
                ....*....|....*....|....*....|....*
gi 1709587  154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:COG0024 133 IAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGH 167
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 18-181 6.47e-15

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 72.87  E-value: 6.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   18 VTKYKMGGDIANRVLRSLVEAsssgvsvlslCEKGDAMImEETGKIFKKEKEMKKGIAFPTSISVNN--CVCHFSPlksd 95
Cdd:cd01066   1 IARLRKAAEIAEAAMAAAAEA----------IRPGVTEA-EVAAAIEQALRAAGGYPAGPTIVGSGArtALPHYRP---- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   96 QDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAH 175
Cdd:cd01066  66 DDRRLQEGDLVLVDLGGVYDGYHADLTRTFVIG-----EPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLE 140


                ....*.
gi 1709587  176 SFNCTP 181
Cdd:cd01066 141 EHGLGP 146
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 76-188 3.00e-12

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 65.83  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587     76 FPTS--ISVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAA 153
Cdd:TIGR00500  62 FPGSvcISVNEVVIHGIP----DKKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVG-----KISPEAEKLLECTEESLYKA 132

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1709587    154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:TIGR00500 133 IEEAKPGNRIGEIGAAIQKYAEAKGFSVVREYCGH 167
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 6-188 6.11e-11

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 62.16  E-value: 6.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587     6 EQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASssgvsvlslcEKG------DAM---IMEETGKI--FKKEKemkkgi 74
Cdd:PRK12896   4 EGRGMEIKSPRELEKMRKIGRIVATALKEMGKAV----------EPGmttkelDRIaekRLEEHGAIpsPEGYY------ 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    75 AFPTS--ISVNNCVCHFSPlkSDQdyILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEA 152
Cdd:PRK12896  68 GFPGStcISVNEEVAHGIP--GPR--VIKDGDLVNIDVSAYLDGYHGDTGITFAVG-----PVSEEAEKLCRVAEEALWA 138

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 1709587   153 ALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:PRK12896 139 GIKQVKAGRPLNDIGRAIEDFAKKNGYSVVRDLTGH 174
PRK12318 PRK12318
methionyl aminopeptidase;
76-188 1.42e-09

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 58.68  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587    76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqgtQVTGRKADVIKAAHLCAEAA 153
Cdd:PRK12318 104 FPKTIctSLNEVICHGIP----NDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIG-----EVSEIKKKVCQASLECLNAA 174

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 1709587   154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:PRK12318 175 IAILKPGIPLYEIGEVIENCADKYGFSVVDQFVGH 209
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
67-173 3.79e-07

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 51.36  E-value: 3.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   67 EKEMKK----GIAFPTSISV--NNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQvtgRKA 140
Cdd:COG0006 114 EAAMRRrgaeGPSFDTIVASgeNAAIPHYTP----TDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQ---REI 186

                        90       100       110
                ....*....|....*....|....*....|....
gi 1709587  141 -DVIKAAHlcaEAALRLVKPGNQNTQVTEAWNKV 173
Cdd:COG0006 187 yEAVLEAQ---EAAIAALKPGVTGGEVDAAARDV 217
PRK15173 PRK15173
peptidase; Provisional
 89-160 2.60e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 45.86  E-value: 2.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1709587    89 FSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaQGTQVTGRKADVIKAAHlcaEAALRLVKPG 160
Cdd:PRK15173 159 FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVG--EPPEITRKIYQTIRTGH---EHMLSMVAPG 225
PRK14575 PRK14575
putative peptidase; Provisional
 89-160 3.79e-05

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 45.47  E-value: 3.79e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1709587    89 FSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaQGTQVTGRKADVIKAAHlcaEAALRLVKPG 160
Cdd:PRK14575 242 FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVG--EPPEITRKIYQTIRTGH---EHMLSMVAPG 308
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 67-160 8.77e-05

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 43.27  E-value: 8.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   67 EKEMKK----GIAFPTSIS--VNNCVCHFSPlkSDQdyILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQvtgRKA 140
Cdd:cd01092  36 EYFMRKlgaeGPSFDTIVAsgPNSALPHGVP--SDR--KIEEGDLVLIDFGAIYDGYCSDITRTVAVGEPSDEL---KEI 108

                        90       100
                ....*....|....*....|.
gi 1709587  141 -DVIKAAHlcaEAALRLVKPG 160
Cdd:cd01092 109 yEIVLEAQ---QAAIKAVKPG 126
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 77-190 2.62e-04

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 42.17  E-value: 2.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709587   77 PTSIS-VNNCVCHFSPLksdqDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaqGtQVTGRKADVIKAAHLCAEAALR 155
Cdd:cd01087  50 YIVAAgSNAAILHYVHN----DQPLKDGDLVLIDAGAEYGGYASDITRTFPVN---G-KFTDEQRELYEAVLAAQKAAIA 121

                        90       100       110
                ....*....|....*....|....*....|....*
gi 1709587  156 LVKPGNQNTQVTEAWNKVAHsfnctpiEGMLSHQL 190
Cdd:cd01087 122 ACKPGVSYEDIHLLAHRVLA-------EGLKELGI 149
PRK14576 PRK14576
putative endopeptidase; Provisional
 88-160 5.64e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 41.92  E-value: 5.64e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1709587    88 HFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGvaQGTQVTGRKADVIKAAHlcaEAALRLVKPG 160
Cdd:PRK14576 240 NFSPKIIADTTPAKVGDLIKFDCGIDVAGYGADLARTFVLG--EPDKLTQQIYDTIRTGH---EHMLSMVAPG 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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