|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
181-1090 |
1.07e-170 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 523.97 E-value: 1.07e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 181 SYPQGQAPPLSQAQGHPGiqtpqrsapsQASSFTPPASGGPRLPSMTGPLlpgqsfggpsvsqpnhvSSPPQALPPGTQM 260
Cdd:COG5028 2 SQHKKGVYPQAQSQVHTG----------AASSKKSARPHRAYANFSAGQM-----------------GMPPYTTPPLQQQ 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 261 TGPLGPLP--PMHspqQPGYQPQQNGSFGPARGPQSNYGGPYPAAPTFGSqpgppqplppkrLDPDAIPS-PIQVIEDdr 337
Cdd:COG5028 55 SRRQIDQAatAMH---NTGANNPAPSVMSPAFQSQQKFSSPYGGSMADGT------------APKPTNPLvPVDLFED-- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 338 nnrgTEPFVTGVRG----QVPPLvTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPY 413
Cdd:COG5028 118 ----QPPPISDLFLppppIVPPL-TTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVP 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 414 VVDHGEsgPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYc 493
Cdd:COG5028 193 LVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEY- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 494 kNNKFPSPPAFIFMIDVSYNAIRTGLV----RLLCEELKSLLDFLPReggaeesaIRVGFVTYNKVLHFYNVKSSLaQPQ 569
Cdd:COG5028 270 -SLRQPPPPVYVFLIDVSFEAIKNGLVkaaiRAILENLDQIPNFDPR--------TKIAIICFDSSLHFFKLSPDL-DEQ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 570 MMVVSDVADMFVPLLDG-FLVNVNESRAVITSLLDQIPEMFADTRETETVFVPviqagmeALKAA-----ECAGKLFLFH 643
Cdd:COG5028 340 MLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP-------ALKAAksligGTGGKIIVFL 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 644 TSLPIAeAPGKLKNRDDrklintdKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKY 723
Cdd:COG5028 413 STLPNM-GIGKLQLRED-------KESSLLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFY 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 724 ASFQVE--NDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNE 801
Cdd:COG5028 485 PNFSATrpNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLMT 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 802 eSGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILAC 881
Cdd:COG5028 565 -SDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKA 643
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 882 YRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAeVTTDDRAYVRQLVTSMDVTETNVFFYPRLLPLTKSPVES 961
Cdd:COG5028 644 YKKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSGS-TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEA 722
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 962 -------TTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRG 1034
Cdd:COG5028 723 glpdeglLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRN 802
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 1035 LIDSLRaQRSRYMKLTVVKQED----KMEMLFKHFLVEDKSLsGGASYVDFLCHMHKEIR 1090
Cdd:COG5028 803 IIGELR-SVNDDSTLPLVLVRGggdpSLRLWFFSTLVEDKTL-NIPSYLDYLQILHEKIK 860
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
499-758 |
4.33e-124 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 379.31 E-value: 4.33e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 499 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREggaeESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 578
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGD----DPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 579 MFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKaaECAGKLFLFHTSLPIAEApGKLKNR 658
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 659 DDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQvendqerflSD 738
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN---------FS 224
|
250 260
....*....|....*....|
gi 257051070 739 LRRDVQKVVGFDAVMRVRTS 758
Cdd:cd01479 225 APNDVEKLVNELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
499-743 |
2.81e-116 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 358.87 E-value: 2.81e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 499 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREggaeeSAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 578
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGD-----PRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 579 MFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNR 658
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 659 DDRKLINTDKEKTLFQPQT-GAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFLS 737
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 257051070 738 DLRRDV 743
Cdd:pfam04811 236 DLQRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
499-741 |
3.07e-104 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 326.89 E-value: 3.07e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 499 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGAeesaiRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 578
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRA-----RVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 579 MFVPLLDGFLVNVNESRAVITSLLDQIPEMFAD--TRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEaPGKLK 656
Cdd:cd01468 76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 657 NRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFL 736
Cdd:cd01468 155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234
|
....*
gi 257051070 737 SDLRR 741
Cdd:cd01468 235 QDLQR 239
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
19-1091 |
1.72e-47 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 186.05 E-value: 1.72e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 19 IYPGYHqssyGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGapPASTAQAPCgqAAYGQFGQgdvQNGPSST 98
Cdd:PTZ00395 338 IYGGFH----DGSPNAASAGAPFNGLGNQADGGHINQVHPDARGAWAGG--PHSNASYNC--AAYSNAAQ---SNAAQSN 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 99 VQMQRLPGSQPfGSPLAPVGNQPPVLQPYGPPPTSAqvaTQLSGmqisgavapaPPSSGlgfgPPTSlasasgSFPNSGL 178
Cdd:PTZ00395 407 AGFSNAGYSNP-GNSNPGYNNAPNSNTPYNNPPNSN---TPYSN----------PPNSN----PPYS------NLPYSNT 462
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 179 -YGSYPQGQAPPLSQAQGHPGIQTP-QRSAPSQASSFTPPASGGPRLPSMTGPllpGQSFGGPSVSQPnhVSSPPQALPP 256
Cdd:PTZ00395 463 pYSNAPLSNAPPSSAKDHHSAYHAAyQHRAANQPAANLPTANQPAANNFHGAA---GNSVGNPFASRP--FGSAPYGGNA 537
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 257 GTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAPT-FGSQPGPPQPLPPKRLDPDAIPSPIQVIED 335
Cdd:PTZ00395 538 ATTADPNGIAKREDHPEGGTNRQKYEQSDEESVESSSSENSSENENEVTdKGEEIYSLLKKTINRIDMNKIPRPIINTQE 617
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 336 DRNNRGTEPFVTgVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYV- 414
Cdd:PTZ00395 618 KKKKKNLKVFET-CKYISPPSYYQPYISIDTGKADPRFLKSTLYQIPLFSETLKLSQIPFGIIVNPFACLNEGEGIDKId 696
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 415 ----VDHGESGP--LRCNRCKAYM-CPFMQFIEGGrrFQCCFCSC---IND----------------------------- 455
Cdd:PTZ00395 697 mkdiINDKEENIeiLRCPKCLGYLhATILEDISSS--VQCVFCDTdflINEnvlfdifqynekighkesdhnehgnslsp 774
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 456 ---------VPPQYFQHLD-------HTGKRV----------------------------------------DAYDRPEL 479
Cdd:PTZ00395 775 llkgsvdiiIPPIYYHNVNkfkltytYLNKNInqtafmitnkimsftkhisnslvandskggnkatsasafgDSGDANFL 854
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 480 SLGSY--------------------------------------------EFLATVD------------YCKNN------- 496
Cdd:PTZ00395 855 AGGGYtnyggaggyntydnqsgynnhdvvnnrggsgagnhlygkdhdvqNFDNVMDnanftihdmknlICEKNgepdsak 934
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 497 --------KFPS-----PPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFL--PReggaeesaIRVGFVTYNKVLHFYNV 561
Cdd:PTZ00395 935 irrnsflaKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIRYAVQNVkcPQ--------TKIAIITFNSSIYFYHC 1006
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 562 KSSLAQP-------------QMMVVSDVADMFVPL-LDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGM 627
Cdd:PTZ00395 1007 KGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAM 1086
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 628 EALKAAECAGKLFLFHTSLPIAeAPGKLKnrddrKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFP--NQYVD 705
Cdd:PTZ00395 1087 DMLKERNGLGSICMFYTTTPNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFIISsnNVRVC 1160
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 706 VATLSVVPQLTGGSVYKYASFQVEND-QERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTT----DVEL 780
Cdd:PTZ00395 1161 VPSLQYVAQNTGGKILFVENFLWQKDyKEIYMNIMDTLTSEDIAYCCELKLRYSHHMSVKKLFCCNNNFNSIisvdTIKI 1240
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 781 AGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVL 860
Cdd:PTZ00395 1241 PKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNIL 1320
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 861 NSP--VKAVRDTLitqcAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQpgAEVTTDDRAYVRQLVTSM 938
Cdd:PTZ00395 1321 HNDnySKIIIDNL----AAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNVTK--KEILHDLKVYSLIKLLSM 1394
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 939 DVTETNVFFYPRLLPL----TKSPVESTTE------PPAVRASEERLSNGDIYLLENGLNLFLWVG----ASVQQGVVQS 1004
Cdd:PTZ00395 1395 PIISSLLYVYPVMYVIhikgKTNEIDSMDVdddlfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGfhsdANFAKEIVGD 1474
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 1005 LFSVSSFSQitsglsvLPVLDNPLSKKVRGLIDSLRA--QRSRYMKLTVVKQEDKMEMLFKHFLVEDKSlSGGASYVDFL 1082
Cdd:PTZ00395 1475 IPTEKNAHE-------LNLTDTPNAQKVQRIIKNLSRihHFNKYVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFL 1546
|
....*....
gi 257051070 1083 CHMHKEIRQ 1091
Cdd:PTZ00395 1547 CFIHKLVHK 1555
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
845-943 |
1.35e-34 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 127.62 E-value: 1.35e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 845 DTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVT 924
Cdd:pfam04815 3 EAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNSSP 82
|
90
....*....|....*....
gi 257051070 925 TDDRAYVRQLVTSMDVTET 943
Cdd:pfam04815 83 SDERAYARHLLLSLPVEEL 101
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
748-831 |
4.40e-28 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 108.39 E-value: 4.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 748 GFDAVMRVRTSTGIRAVDFFGAFYMSNTTD-VELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHN 826
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDtWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*
gi 257051070 827 LALNC 831
Cdd:pfam08033 81 VALPV 85
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
378-824 |
9.88e-19 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 91.93 E-value: 9.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 378 SYNI-PCTSDMAKQAQVPLAAVIKPLARLPPEEASPYvvdhgesGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDV 456
Cdd:PLN00162 15 SWNVwPSSKIEASKCVIPLAALYTPLKPLPELPVLPY-------DPLRCRTCRAVLNPYCRVDFQAKIWICPFCFQRNHF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 457 PPQYF----QHLDhtgkrvdaydrPELslgsYEFLATVDY---CKNNKFPSPPAFIFMIDVSynAIRTGLvRLLCEELKS 529
Cdd:PLN00162 88 PPHYSsiseTNLP-----------AEL----FPQYTTVEYtlpPGSGGAPSPPVFVFVVDTC--MIEEEL-GALKSALLQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 530 LLDFLPreggaeESAiRVGFVTY----------------------------NKVLHFYNVKSSLAQPQMMVVSDVADMFV 581
Cdd:PLN00162 150 AIALLP------ENA-LVGLITFgthvhvhelgfsecsksyvfrgnkevskDQILEQLGLGGKKRRPAGGGIAGARDGLS 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 582 PL-LDGFLVNVNESRAVITSLLDQI-PEMF---ADTRETETVFVPV-IQAGMEALKAAECAGKLFLFhTSLPIAEAPGKL 655
Cdd:PLN00162 223 SSgVNRFLLPASECEFTLNSALEELqKDPWpvpPGHRPARCTGAALsVAAGLLGACVPGTGARIMAF-VGGPCTEGPGAI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 656 KNRDDRKLINTDKE-----KTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFqven 730
Cdd:PLN00162 302 VSKDLSEPIRSHKDldkdaAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESF---- 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 731 DQERFLSDLRRDVQKV------VGFDAVMRVRTSTGIRAVDFFG---------------AFYMSNTTDVELAGLDGDKTV 789
Cdd:PLN00162 378 GHSVFKDSLRRVFERDgegslgLSFNGTFEVNCSKDVKVQGAIGpcaslekkgpsvsdtEIGEGGTTAWKLCGLDKKTSL 457
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 257051070 790 TVEF----KHDDRLNEESGAL-LQCALLYTSCAGQRRLRI 824
Cdd:PLN00162 458 AVFFevanSGQSNPQPPGQQFfLQFLTRYQHSNGQTRLRV 497
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
422-459 |
3.43e-17 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 75.95 E-value: 3.43e-17
10 20 30
....*....|....*....|....*....|....*...
gi 257051070 422 PLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQ 459
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPPE 38
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
374-951 |
9.29e-17 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 85.70 E-value: 9.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 374 IRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYvvdhgesGPLRCNR-CKAYMCPFMQFIEGGRRFQCCFCSC 452
Cdd:COG5047 12 IRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYY-------EPVKCTApCKAVLNPYCHIDERNQSWICPFCNQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 453 INDVPPQYfqhldhtgkrvDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRtglVRLLCEELKSLLD 532
Cdd:COG5047 85 RNTLPPQY-----------RDISNANLPLELLPQSSTIEYTLSKPVILPPVFFFVVDACCDEEE---LTALKDSLIVSLS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 533 FLPREggaeesAIrVGFVTYNKVLHFYNVkSSLAQPQMMVVSDVADMFVPLLD--------------------------- 585
Cdd:COG5047 151 LLPPE------AL-VGLITYGTSIQVHEL-NAENHRRSYVFSGNKEYTKENLQellalskptksggfeskisgigqfass 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 586 GFLVNVNESRAVITSLLDQI-------PEMFADTRETET-VFVPVIQAGMEALKaaeCAGKLFLFhTSLPIAEAPGKLKN 657
Cdd:COG5047 223 RFLLPTQQCEFKLLNILEQLqpdpwpvPAGKRPLRCTGSaLNIASSLLEQCFPN---AGCHIVLF-AGGPCTVGPGTVVS 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 658 RDDRK------LINTDKEKtLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVEND 731
Cdd:COG5047 299 TELKEpmrshhDIESDSAQ-HSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIF 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 732 QERFLSDLRRDVQK--VVGFDAVMRVRTSTGIRAVDFFG---------------AFYMSNTTDVELAGLDGDKTVTVEFK 794
Cdd:COG5047 378 KQSFQRIFNRDSEGylKMGFNANMEVKTSKNLKIKGLIGhavsvkkkannisdsEIGIGATNSWKMASLSPKSNYALYFE 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 795 HDDRLNEESG-----ALLQCALLYTSCAGQRRLRIHNLALNCCTQLADL-YRNCETDTLINYMAKFAyrgVLNSPVKAVR 868
Cdd:COG5047 458 IALGAASGSAqrpaeAYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIA---AFKAETEDII 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 869 D-------TLITQCaQILACYRKNcaSPSSAGqliLPECMKLLPVYLNCVLKSDVLQPGAEvTTDDRAYVRQLVTSMDVT 941
Cdd:COG5047 535 DvfrwidrNLIRLC-QKFADYRKD--DPSSFR---LDPNFTLYPQFMYHLRRSPFLSVFNN-SPDETAFYRHMLNNADVN 607
|
650
....*....|
gi 257051070 942 ETNVFFYPRL 951
Cdd:COG5047 608 DSLIMIQPTL 617
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
4-329 |
1.07e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 79.60 E-value: 1.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 4 NQSVPPVPPfgQPQPIYPGY----HQSSYGGQSGS-TAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPC 78
Cdd:PHA03247 2565 DRSVPPPRP--APRPSEPAVtsraRRPDAPPQSARpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHP 2642
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 79 GQAAYGQFGQGDV-----------------QNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLS 141
Cdd:PHA03247 2643 PPTVPPPERPRDDpapgrvsrprrarrlgrAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 142 -GMQISGAVAPAPPSSGLGFGPPTSLASASG-SFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPAsg 219
Cdd:PHA03247 2723 pGPAAARQASPALPAAPAPPAVPAGPATPGGpARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS-- 2800
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 220 gPRLPSMTGPLLPGQSFGGPSVSQPnhvsSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFgpARGPQSNYGGP 299
Cdd:PHA03247 2801 -PWDPADPPAAVLAPAAALPPAASP----AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDV--RRRPPSRSPAA 2873
|
330 340 350
....*....|....*....|....*....|
gi 257051070 300 YPAAPTFGSQPGPPQPLPPKRLDPDAIPSP 329
Cdd:PHA03247 2874 KPAAPARPPVRRLARPAVSRSTESFALPPD 2903
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
961-1036 |
2.74e-12 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 63.10 E-value: 2.74e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257051070 961 STTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQgvVQSLFSVSSFSQI-TSGLSVLPVLDN-PLSKKVRGLI 1036
Cdd:pfam00626 1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKGSSL--LEKLFAALLAAQLdDDERFPLPEVIRvPQGKEPARFL 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
8-304 |
5.79e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 70.74 E-value: 5.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 8 PPVPPFGQPQPIYPGYHQSSYGGQSGSTAPA-----IPYGAYNGPV----------PGYQQTPPQGMSRAPPSSGAPPAS 72
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPAlpaapAPPAVPAGPAtpggparparPPTTAGPPAPAPPAAPAAGPPRRL 2783
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 73 TAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVgnqppvlqpygPPPTSAQvatqlsgmqisgavaPA 152
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL-----------PPPTSAQ---------------PT 2837
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 153 PPSSGLGFgPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQAS-SFTPPASGGPRLPSmtgPLL 231
Cdd:PHA03247 2838 APPPPPGP-PPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTeSFALPPDQPERPPQ---PQA 2913
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257051070 232 PGQSFGGPSVSQPNHVSSPPQAlPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAP 304
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPP-PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPS 2985
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
6-271 |
8.47e-12 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 69.80 E-value: 8.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 6 SVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPgyqQTPPQGMSRAPPSSGAPPASTAQ---------- 75
Cdd:pfam03154 202 SAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSP---HPPLQPMTQPPPPSQVSPQPLPQpslhgqmppm 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 76 ---------------APCGQAAYGQFGQGDVQNGPSSTV-----QMQRLPGSQPFGSPLAPVGNQP----PVLQPY-GPP 130
Cdd:pfam03154 279 phslqtgpshmqhpvPPQPFPLTPQSSQSQVPPGPSPAApgqsqQRIHTPPSQSQLQSQQPPREQPlppaPLSMPHiKPP 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 131 PTS--AQVATQLSGMQISGAVAPAPPSSGLGFGPPTS---LASASGSFPNSG------LYGSYPQGQAPP-----LSQAQ 194
Cdd:pfam03154 359 PTTpiPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPAlkpLSSLSTHHPPSAhppplqLMPQSQQLPPPPaqppvLTQSQ 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 195 GHP--GIQTPQRSAPSQASSfTPPASGGPRLPSMTGPLLPGQsfgGPSVSQPNHVSS--PPQALPPGTQMTGPLG---PL 267
Cdd:pfam03154 439 SLPppAASHPPTSGLHQVPS-QSPFPQHPFVPGGPPPITPPS---GPPTSTSSAMPGiqPPSSASVSSSGPVPAAvscPL 514
|
....
gi 257051070 268 PPMH 271
Cdd:pfam03154 515 PPVQ 518
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
8-305 |
1.74e-11 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 68.64 E-value: 1.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 8 PPVPPFGQPQPIYPGYHQSSyggqsgstAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGA--PPASTAQAPcgqaaygq 85
Cdd:pfam03154 255 PPPPSQVSPQPLPQPSLHGQ--------MPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSqvPPGPSPAAP-------- 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 86 fgqgdvqnGPSStvQMQRLPGSQPFGSPLAPVGNQP----PVLQPY-GPPPTS--AQVATQLSGMQISGAVAPAPPSSGL 158
Cdd:pfam03154 319 --------GQSQ--QRIHTPPSQSQLQSQQPPREQPlppaPLSMPHiKPPPTTpiPQLPNPQSHKHPPHLSGPSPFQMNS 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 159 GFGPPTSLAsasgsfPNSGLYGSYPQGQAPPLSQ--AQGHPgIQTPQRSAP--SQASSFTPPASGGPrlPSMTGPLLPGQ 234
Cdd:pfam03154 389 NLPPPPALK------PLSSLSTHHPPSAHPPPLQlmPQSQQ-LPPPPAQPPvlTQSQSLPPPAASHP--PTSGLHQVPSQ 459
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257051070 235 SfggPSVSQPNHVSSPPQALPPGTqmtgplgplPPMHSPQQPGyqpqqngSFGPARGPQSNYGGPYPAAPT 305
Cdd:pfam03154 460 S---PFPQHPFVPGGPPPITPPSG---------PPTSTSSAMP-------GIQPPSSASVSSSGPVPAAVS 511
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
6-254 |
3.71e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.49 E-value: 3.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 6 SVPPVPPFGQPQPIYPGYHQSSYGGQSGS----TAPAIPYGAYNGPVPGYQQT--------PPQGMSRAPPSSGAPPAST 73
Cdd:PHA03247 2769 PAPPAAPAAGPPRRLTRPAVASLSESRESlpspWDPADPPAAVLAPAAALPPAaspagplpPPTSAQPTAPPPPPGPPPP 2848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 74 AQAPCGQAAYGqfgqGDVQNGPSStvqmqRLPGSQPFGSPLAPVGN--------------QPPVLQPYGPPPTSAQVATQ 139
Cdd:PHA03247 2849 SLPLGGSVAPG----GDVRRRPPS-----RSPAAKPAAPARPPVRRlarpavsrstesfaLPPDQPERPPQPQAPPPPQP 2919
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 140 LSGMQISGAVAPAPPSSGLgfgPPTSLASASGSFPNSGlygsyPQGQAPPLSQAQGHPG-IQTPQRSAPSQASSFTPPAs 218
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPR---PQPPLAPTTDPAGAGE-----PSGAVPQPWLGALVPGrVAVPRFRVPQPAPSREAPA- 2990
|
250 260 270
....*....|....*....|....*....|....*.
gi 257051070 219 ggPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQAL 254
Cdd:PHA03247 2991 --SSTPPLTGHSLSRVSSWASSLALHEETDPPPVSL 3024
|
|
| SPT5 |
COG5164 |
Transcription elongation factor SPT5 [Transcription]; |
30-269 |
2.78e-08 |
|
Transcription elongation factor SPT5 [Transcription];
Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 57.73 E-value: 2.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 30 GQSGSTAPAIPYGAyngpvpgyqQTPPQgmsraPPSSGAPPAST-AQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQ 108
Cdd:COG5164 22 GSQGSTKPAQNQGS---------TRPAG-----NTGGTRPAQNQgSTTPAGNTGGTRPAGNQGATGPAQNQGGTTPAQNQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 109 pfGSPLAPvGNQPPVLQPYGPPPTSAQVATQLSGMQISGAvAPAPPSSGlgfgpPTSLASASGSFPNSGLYGSYPQGQAP 188
Cdd:COG5164 88 --GGTRPA-GNTGGTTPAGDGGATGPPDDGGATGPPDDGG-STTPPSGG-----STTPPGDGGSTPPGPGSTGPGGSTTP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 189 PLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPqalPPGTQMTGPLGPLP 268
Cdd:COG5164 159 PGDGGSTTPPGPGGSTTPPDDGGSTTPPNKGETGTDIPTGGTPRQGPDGPVKKDDKNGKGNPP---DDRGGKTGPKDQRP 235
|
.
gi 257051070 269 P 269
Cdd:COG5164 236 K 236
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
6-304 |
3.27e-08 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 58.26 E-value: 3.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 6 SVPPVPPFGQPQPIYPGYHQSSY--GGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRA--PPSSGAPPASTAQAPCGQA 81
Cdd:PHA03307 85 RSTPTWSLSTLAPASPAREGSPTppGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSpgPPPAASPPAAGASPAAVAS 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 82 AYGQFGQ-GDVQNGPSSTVQmqrlPGSQPfgsPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGF 160
Cdd:PHA03307 165 DAASSRQaALPLSSPEETAR----APSSP---PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSS 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 161 GPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRsAPSQASSFTPPASGGPRLPSM--TGPLLPGQSFGG 238
Cdd:PHA03307 238 DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSR-PGPASSSSSPRERSPSPSPSSpgSGPAPSSPRASS 316
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257051070 239 PSVSQPNHVSSPPQALPPGTQMTGPlGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAP 304
Cdd:PHA03307 317 SSSSSRESSSSSTSSSSESSRGAAV-SPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS 381
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
71-299 |
1.06e-07 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 56.17 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 71 ASTAQAPCGQAAYGQFGQGdvQNG---PSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLS--GMQI 145
Cdd:pfam09606 57 AAQQQQPQGGQGNGGMGGG--QQGmpdPINALQNLAGQGTRPQMMGPMGPGPGGPMGQQMGGPGTASNLLASLGrpQMPM 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 146 SGAVAPAPPSSGLGFGPPtslASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPS 225
Cdd:pfam09606 135 GGAGFPSQMSRVGRMQPG---GQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 226 MT-------------GPLLPGQSFGGPsvsqPNHVSSPPQALPPGTQMTGPLGPLPPMHspqqpgyQPQQNGSFGPARGP 292
Cdd:pfam09606 212 PAdagaqmgqqaqanGGMNPQQMGGAP----NQVAMQQQQPQQQGQQSQLGMGINQMQQ-------MPQGVGGGAGQGGP 280
|
....*..
gi 257051070 293 QSNYGGP 299
Cdd:pfam09606 281 GQPMGPP 287
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
5-269 |
1.08e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 56.31 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 5 QSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMS----RAPPSSGAPPASTAQA---P 77
Cdd:pfam03154 296 QPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSmphiKPPPTTPIPQLPNPQShkhP 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 78 CGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQP------------FGSPLAPVGNQPPVL-QPYGPPPTSAQVATQlSGMQ 144
Cdd:pfam03154 376 PHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPpsahppplqlmpQSQQLPPPPAQPPVLtQSQSLPPPAASHPPT-SGLH 454
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 145 ISGAVAPAPPSSGLGFGPPTSLasasgsfPNSGlygsypqgqaPPLSQAQGHPGIQTPqrsapsqasSFTPPASGGPrLP 224
Cdd:pfam03154 455 QVPSQSPFPQHPFVPGGPPPIT-------PPSG----------PPTSTSSAMPGIQPP---------SSASVSSSGP-VP 507
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 257051070 225 SMTGPLLPGQSFGGPSVSQPNHVSSPPqalPPgtqmtgPLGPLPP 269
Cdd:pfam03154 508 AAVSCPLPPVQIKEEALDEAEEPESPP---PP------PRSPSPE 543
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
120-304 |
1.74e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.54 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 120 QPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLAsasgsfPNSglygsyPQGQAPPLSQAQGHPGI 199
Cdd:pfam03154 170 QPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQP------PNQ------TQSTAAPHTLIQQTPTL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 200 QTPQRSAP----SQASSFTPPASGGPRL---PSMTGPLLPGqsfGGPSVSQPNHVSSP--PQALPPGTQMTGPLGPLPPM 270
Cdd:pfam03154 238 HPQRLPSPhpplQPMTQPPPPSQVSPQPlpqPSLHGQMPPM---PHSLQTGPSHMQHPvpPQPFPLTPQSSQSQVPPGPS 314
|
170 180 190
....*....|....*....|....*....|....*
gi 257051070 271 HSPQQPGYQPQQN-GSFGPARGPQSNYGGPYPAAP 304
Cdd:pfam03154 315 PAAPGQSQQRIHTpPSQSQLQSQQPPREQPLPPAP 349
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
5-241 |
3.44e-07 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 53.74 E-value: 3.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 5 QSVPPVPPfgqPQPIYpgyhqsSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPAStaqAPCGQAAYG 84
Cdd:COG5651 163 ALTPFTQP---PPTIT------NPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIG---LNSGPGNTG 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 85 QFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPT 164
Cdd:COG5651 231 FAGTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGL 310
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 257051070 165 SLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPqrSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSV 241
Cdd:COG5651 311 GAGGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAA--AAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
9-271 |
4.13e-07 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 54.30 E-value: 4.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 9 PVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYG-AYNGP--------VPGYQQTPPqgmsRAPPSSGAPPASTAQAPCG 79
Cdd:PHA03378 642 TFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQpSPTGAntmlpiqwAPGTMQPPP----RAPTPMRPPAAPPGRAQRP 717
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 80 QAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSP-------LAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPA 152
Cdd:PHA03378 718 AAATGRARPPAAAPGRARPPAAAPGRARPPAAAPgrarppaAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQ 797
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 153 PPSSglgfGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGP--- 229
Cdd:PHA03378 798 PPPQ----AGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPvfy 873
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 257051070 230 ---LLPGQSFGGPSVSQPNHVSSPPQAlppGTQMTGPLGPLPPMH 271
Cdd:PHA03378 874 ppvLQPIQVMRQLGSVRAAAASTVTQA---PTEYTGERRGVGPMH 915
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
29-233 |
4.70e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 54.11 E-value: 4.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 29 GGQSGSTAPAIPYGAyngpvPGYQQTPPQGMSR-APPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPS-STVQMQRLPG 106
Cdd:PRK12323 366 GQSGGGAGPATAAAA-----PVAQPAPAAAAPAaAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPApEALAAARQAS 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 107 SQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPtSLASASGSFPNSGLYGSYPqgq 186
Cdd:PRK12323 441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP-PWEELPPEFASPAPAQPDA--- 516
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 257051070 187 APPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPG 233
Cdd:PRK12323 517 APAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
8-197 |
2.30e-06 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 51.98 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 8 PPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAP--PSSGAPPASTAQAPC-GQAAYG 84
Cdd:PHA03377 770 PQAPYLGYQEPQAQGVQVSSYPGYAGPWGLRAQHPRYRHSWAYWSQYPGHGHPQGPwaPRPPHLPPQWDGSAGhGQDQVS 849
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 85 QFGQGDVQNGPSS--TVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAqvatqlsgmqisgavapAPPSSGLGFGP 162
Cdd:PHA03377 850 QFPHLQSETGPPRlqLSQVPQLPYSQTLVSSSAPSWSSPQPRAPIRPIPTRF-----------------PPPPMPLQDSM 912
|
170 180 190
....*....|....*....|....*....|....*
gi 257051070 163 PTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHP 197
Cdd:PHA03377 913 AVGCDSSGTACPSMPFASDYSQGAFTPLDINAQTP 947
|
|
| MISS |
pfam15822 |
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ... |
102-304 |
2.84e-06 |
|
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.
Pssm-ID: 318115 [Multi-domain] Cd Length: 238 Bit Score: 49.98 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 102 QRLPGSQPFGSPLAPVG-------NQPPVLQPYGPPPTSAQVATQLSGMQiSGAVAPAPPsSGLGFGPPtslasaSGSFP 174
Cdd:pfam15822 28 QGWPGSNPWNNPSAPPAvpsglppSTAPSTVPFGPAPTGMYPSIPLTGPS-PGPPAPFPP-SGPSCPPP------GGPYP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 175 NSGLYGSYPQGQAPPlsqaqghPGIQTPQrsAPSQASSFTPPASGGPRLP--SM-TGPLLPGQSFGGPSVSQPNHVSSPP 251
Cdd:pfam15822 100 APTVPGPGPIGPYPT-------PNMPFPE--LPRPYGAPTDPAAAAPSGPwgSMsSGPWAPGMGGQYPAPNMPYPSPGPY 170
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 257051070 252 QALPP----GTQMTGPLGPLPPmhspqqpgyqpQQNGSFGPARGPQSNYG--GPYPAAP 304
Cdd:pfam15822 171 PAVPPpqspGAAPPVPWGTVPP-----------GPWGPPAPYPDPTGSYPmpGLYPTPN 218
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
40-256 |
3.32e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.53 E-value: 3.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 40 PYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAygqfgqgdvqngPSSTVQMQRLPGSQPFGSPLAPVGN 119
Cdd:PRK07764 592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAA------------APAEASAAPAPGVAAPEHHPKHVAV 659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 120 QPPVLQPYGPPPTSAQVAtqlsgmQISGAVAPAPPSSGLGFGPPTSLASASGSfpnsglygsyPQGQAPPLSQAQGHPGI 199
Cdd:PRK07764 660 PDASDGGDGWPAKAGGAA------PAAPPPAPAPAAPAAPAGAAPAQPAPAPA----------ATPPAGQADDPAAQPPQ 723
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 257051070 200 QTPQRSAPSQASSFTPPASGGPRLPSMTGPlLPGQSFGGPSVSQPNHVSSPPQALPP 256
Cdd:PRK07764 724 AAQGASAPSPAADDPVPLPPEPDDPPDPAG-APAQPPPPPAPAPAAAPAAAPPPSPP 779
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
8-139 |
4.59e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.75 E-value: 4.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 8 PPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAiPYGAYNGPVPGYQQTPPQGmsrAPPSSGAPPASTAQAPCGQAAYGQFG 87
Cdd:PRK07764 652 HHPKHVAVPDASDGGDGWPAKAGGAAPAAPP-PAPAPAAPAAPAGAAPAQP---APAPAATPPAGQADDPAAQPPQAAQG 727
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 257051070 88 QGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQ 139
Cdd:PRK07764 728 ASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
9-301 |
9.38e-06 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 50.01 E-value: 9.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 9 PVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGP-VPGYQQTPPQGMS-------RAPPSSGAPPASTAQAPCGQ 80
Cdd:pfam09606 133 PMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPnQMGPNGGPGQGQAggmnggqQGPMGGQMPPQMGVPGMPGP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 81 AAYGqfGQGDVQNGPSSTVQMQRLPGSQPfgsplapvgNQPPVLQPYGPPPTSAQVATQLSGMQ--------ISGAVAPA 152
Cdd:pfam09606 213 ADAG--AQMGQQAQANGGMNPQQMGGAPN---------QVAMQQQQPQQQGQQSQLGMGINQMQqmpqgvggGAGQGGPG 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 153 PPSSGLGFGPPTSLASASGSFPNSGLYgsyPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLP 232
Cdd:pfam09606 282 QPMGPPGQQPGAMPNVMSIGDQNNYQQ---QQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFG 358
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 257051070 233 GQSFGGPSVSQPNHVSSP-PQALPPGTQMTGPLG----PLPPMHSPQQPGyqpqqngsfgpARGPQSNYGGPYP 301
Cdd:pfam09606 359 GLGANPMQRGQPGMMSSPsPVPGQQVRQVTPNQFmrqsPQPSVPSPQGPG-----------SQPPQSHPGGMIP 421
|
|
| PBP1 |
COG5180 |
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ... |
11-266 |
9.50e-06 |
|
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];
Pssm-ID: 444064 [Multi-domain] Cd Length: 548 Bit Score: 49.68 E-value: 9.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 11 PPFGQPQPIyPGYHQSSYGGQSGSTAPAIPYGAYNGP-VPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQF-GQ 88
Cdd:COG5180 202 PKVEVKDEA-QEEPPDLTGGADHPRPEAASSPKVDPPsTSEARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPpGL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 89 GDVQNGPSStvQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGmQISGAVAPAPPSSGLGFGPPTSLAS 168
Cdd:COG5180 281 PVLEAGSEP--QSDAPEAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPG-QPTERPAGVPEAASDAGQPPSAYPP 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 169 ASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPS--VSQPNH 246
Cdd:COG5180 358 AEEAVPGKPLEQGAPRPGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAAggAGQGPK 437
|
250 260
....*....|....*....|
gi 257051070 247 VSSPPQALPPGTQMTGPLGP 266
Cdd:COG5180 438 ADFVPGDAESVSGPAGLADQ 457
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
5-304 |
1.06e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 49.78 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 5 QSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGM---------SRAPPSSGAPPASTAQ 75
Cdd:PHA03307 119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAAlplsspeetARAPSSPPAEPPPSTP 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 76 ------------------APCGQAAYGQFGQGDVQNGPSSTVQMQR------------LPGSQPFGSPLAPVGNQPPVLQ 125
Cdd:PHA03307 199 paaasprpprrsspisasASSPAPAPGRSAADDAGASSSDSSSSESsgcgwgpenecpLPRPAPITLPTRIWEASGWNGP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 126 PYGPPPTSAQVATQLSgmqiSGAVAPAPPSSGLGFGPPTSLASASGSfPNSGLYGSYPQGQAPplSQAQGHPGiQTPQRS 205
Cdd:PHA03307 279 SSRPGPASSSSSPRER----SPSPSPSSPGSGPAPSSPRASSSSSSS-RESSSSSTSSSSESS--RGAAVSPG-PSPSRS 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 206 APSQASSftPPASGGPrlPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPlGPLPPMHSPQQPGYQPQQNGS 285
Cdd:PHA03307 351 PSPSRPP--PPADPSS--PRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDAT-GRFPAGRPRPSPLDAGAASGA 425
|
330 340
....*....|....*....|
gi 257051070 286 FgPARGPQ-SNYGGPYPAAP 304
Cdd:PHA03307 426 F-YARYPLlTPSGEPWPGSP 444
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
40-304 |
1.40e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 40 PYGAYNGPVPGYQQTPPqgmSRAPPSSGAP-PASTAQAPCGQAAYGQFGQ---------GDVQNGPSSTvqmqrLPGSQP 109
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPD---PDAPPAPSRLaPAILPDEPVGEPVHPRMLTwirgleelaSDDAGDPPPP-----LPPAAP 2560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 110 FGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSL----------ASASGSFPNSGLY 179
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLppdthapdppPPSPSPAANEPDP 2640
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 180 GSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPAS-GGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQA----- 253
Cdd:PHA03247 2641 HPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALvsatp 2720
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 257051070 254 LPPGTQMTGPLGPLPPMH-SPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAP 304
Cdd:PHA03247 2721 LPPGPAAARQASPALPAApAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
105-305 |
1.60e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.21 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 105 PGSQPFGSPLAPVGNQPP--VLQPYGPPPTSAQVATQlsgmQISGAVAPAPPSSGLGFGPPTSLASASGsfpnsglygsy 182
Cdd:PRK07764 592 PGAAGGEGPPAPASSGPPeeAARPAAPAAPAAPAAPA----PAGAAAAPAEASAAPAPGVAAPEHHPKH----------- 656
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 183 PQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTG 262
Cdd:PRK07764 657 VAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAAD 736
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 257051070 263 PLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAPT 305
Cdd:PRK07764 737 DPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
29-266 |
1.93e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 48.69 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 29 GGQSGSTAPAIPY-GAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGS 107
Cdd:PRK07003 370 GGVPARVAGAVPApGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPV 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 108 QPFGSPLAPVGNQPPVLQPyGPPPTSAQVATQLSGMQISGAVAPAPPSSGLgfGPPTSLASASGSFPNSGLYGSYPQGQA 187
Cdd:PRK07003 450 PAKANARASADSRCDERDA-QPPADSGSASAPASDAPPDAAFEPAPRAAAP--SAATPAAVPDARAPAAASREDAPAAAA 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 188 PPLSQA-QGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSfgGPSVSQPnhVSSPPQALPPGTQMTGPLGP 266
Cdd:PRK07003 527 PPAPEArPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAA--KPAAAPA--AAPKPAAPRVAVQVPTPRAR 602
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
29-224 |
3.24e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.06 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 29 GGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPA--STAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPG 106
Cdd:PRK07764 595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAeaSAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAG 674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 107 S-QPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAvAPAPPSSGLGFGPPTSLASASGSFPNsglYGSYPQG 185
Cdd:PRK07764 675 GaAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDP-AAQPPQAAQGASAPSPAADDPVPLPP---EPDDPPD 750
|
170 180 190
....*....|....*....|....*....|....*....
gi 257051070 186 QAPPLSQAQGHPGiqTPQRSAPSQASSFTPPASGGPRLP 224
Cdd:PRK07764 751 PAGAPAQPPPPPA--PAPAAAPAAAPPPSPPSEEEEMAE 787
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
5-222 |
5.54e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 47.29 E-value: 5.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 5 QSVPPVPPFGQPQPiypgyhqssyggqSGSTAPAIPygayNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYG 84
Cdd:PRK07764 602 APASSGPPEEAARP-------------AAPAAPAAP----AAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 85 QFGQGDVQNGPSSTVQMqrlPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPT 164
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAP---PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 257051070 165 SLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPR 222
Cdd:PRK07764 742 PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRR 799
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
11-268 |
1.02e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 46.60 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 11 PPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGP-------VPGYQQTPPQGMSRAPPSSGAPPA--STAQAP---- 77
Cdd:PHA03378 580 PTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPetsaprqWPMPLRPIPMRPLRMQPITFNVLVfpTPHQPPqvei 659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 78 -CGQAAYGQFGQGDVQ---NGPSSTVQMQRLPGS-QPfgSPLAPVGNQPPVLqpygpPPTSAQVATQLSGMQISGAVAPA 152
Cdd:PHA03378 660 tPYKPTWTQIGHIPYQpspTGANTMLPIQWAPGTmQP--PPRAPTPMRPPAA-----PPGRAQRPAAATGRARPPAAAPG 732
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 153 ---PPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAP----PLSQAQGHPGIQTPQRSAPSQassfTPPASGGP---- 221
Cdd:PHA03378 733 rarPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPgaptPQPPPQAPPAPQQRPRGAPTP----QPPPQAGPtsmq 808
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 257051070 222 -RLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLP 268
Cdd:PHA03378 809 lMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTP 856
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
32-263 |
1.46e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 45.72 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 32 SGSTAPAIPYGAYNGPVPGYQQT-----PPQGMSRAPPSSGAPPASTAQAPCG---------QAAYGQFGQGDVQNGPSS 97
Cdd:pfam17823 180 SSTTAASSTTAASSAPTTAASSApatltPARGISTAATATGHPAAGTALAAVGnsspaagtvTAAVGTVTPAALATLAAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 98 TVQMQRLPGSQPFGSP----LAPVGNQPPVLQPYGPPPTS--------AQVATQLSGMQISGAVAPAPPSSGLGFGPPTS 165
Cdd:pfam17823 260 AGTVASAAGTINMGDPharrLSPAKHMPSDTMARNPAAPMgaqaqgpiIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKS 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 166 LASASGSFPNSglygSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSftppasggprlPSmtgPLLPGQSFGGPSVSQ-P 244
Cdd:pfam17823 340 VASTNLAVVTT----TKAQAKEPSASPVPVLHTSMIPEVEATSPTTQ-----------PS---PLLPTQGAAGPGILLaP 401
|
250
....*....|....*....
gi 257051070 245 NHVSSPPQalpPGTQMTGP 263
Cdd:pfam17823 402 EQVATEAT---AGTASAGP 417
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
7-268 |
1.95e-04 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 45.30 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 7 VPPVPP-FGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNgpvpgyQQTPPQGMSRAPPSSGAPPASTAQApcgqaaygq 85
Cdd:PLN03209 339 PKPVPTkPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYE------DLKPPTSPIPTPPSSSPASSKSVDA--------- 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 86 FGQGDVQNGPSSTVQMQRLPGSQPFGsplAPVGNQPPvLQPYG-----PPPTSAqvatqlsgmqisgavAPAPPSsglGF 160
Cdd:PLN03209 404 VAKPAEPDVVPSPGSASNVPEVEPAQ---VEAKKTRP-LSPYAryedlKPPTSP---------------SPTAPT---GV 461
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 161 GPPTSLASASGSFPNSGLYGSYPQGQAPPlsQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPS 240
Cdd:PLN03209 462 SPSVSSTSSVPAVPDTAPATAATDAAAPP--PANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPT 539
|
250 260 270
....*....|....*....|....*....|...
gi 257051070 241 --VSQPNHVSSPPQALPPGT---QMTGPLGPLP 268
Cdd:PLN03209 540 alADEQHHAQPKPRPLSPYTmyeDLKPPTSPTP 572
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
5-242 |
2.83e-04 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 44.92 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 5 QSVPPVPPFGQPQPIYPGYHQSSYGG-------------QSGST-APAIPY--------GAYNGPVPGYQQTPPQGMSRA 62
Cdd:cd22540 159 QVLQQPQQAHKPVPIKPAPLQTSNTNsaslqvpgnviklQSGGNvALTLPVnnlvgtqdGATQLQLAAAPSKPSKKIRKK 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 63 PPSSGAPPASTAQAPcgQAAYGQFGQGD-VQNGPSSTVQMQrlPGSqpfGSPlaPVGNQPPVLQPYGPPpTSAQVATQ-L 140
Cdd:cd22540 239 SAQAAQPAVTVAEQV--ETVLIETTADNiIQAGNNLLIVQS--PGT---GQP--AVLQQVQVLQPKQEQ-QVVQIPQQaL 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 141 SGMQISGAVAPAPPSSglgfgPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPP-ASG 219
Cdd:cd22540 309 RVVQAASATLPTVPQK-----PLQNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEAPAATATPSSSTSTVQQQVTANnGTG 383
|
250 260
....*....|....*....|....*
gi 257051070 220 GPRLPSMT--GPLLPGQSFGGPSVS 242
Cdd:cd22540 384 TSKPNYNVrkERTLPKIAPAGGIIS 408
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
52-410 |
2.96e-04 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 44.68 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 52 QQTPPQGMSRAPPSSGAPPASTAQAPcgqAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLA-PVGNQPPVLQPYGPp 130
Cdd:pfam03546 129 QVRPASTVGKGPSGKGANPAPPGKAG---SAAPLVQVGKKEEDSESSSEESDSEGEAPPAATQAkPSGKILQVRPASGP- 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 131 ptsaqvatqlsgmqiSGAVAPAPPSSGlgfGPPTSLASASGSFPNSGLY--GSYPQGQAPP-LSQAQGHPGIQTPQRSA- 206
Cdd:pfam03546 205 ---------------AKGAAPAPPQKA---GPVATQVKAERSKEDSESSeeSSDSEEEAPAaATPAQAKPALKTPQTKAs 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 207 PSQASSFTP-PASGGPRLPSMTGPLLPGqsfggpSVSQPNHVSSPpqALPPGTQMtgplgplPPMHSPQQPGYQPQQNGS 285
Cdd:pfam03546 267 PRKGTPITPtSAKVPPVRVGTPAPWKAG------TVTSPACASSP--AVARGAQR-------PEEDSSSSEESESEEETA 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 286 FGPARGPQSNYG----GPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNR---GTEPfVTGVRGQVPPLVT 358
Cdd:pfam03546 332 PAAAVGQAKSVGkglqGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEeesDSEE-AAATPAQVKASGK 410
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 257051070 359 TNflvkdQGNASPRYIRCTSYNIPCTS-----DMAKQAQVPLAAVIKPLARLPPEEA 410
Cdd:pfam03546 411 TP-----QAKANPAPTKASSAKGAASApgkvvAAAAQAKQGSPAKVKPPARTPQNSA 462
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
59-331 |
3.03e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 45.06 E-value: 3.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 59 MSRAPPSSGAPPASTAQAPCgqAAYGQFGQGDVQNGPSSTVQMQRLPGSQPfgsplAPVGNQPPVLQPYGPPPTSAQVAT 138
Cdd:PHA03378 521 MATLLPPSPPQPRAGRRAPC--VYTEDLDIESDEPASTEPVHDQLLPAPGL-----GPLQIQPLTSPTTSQLASSAPSYA 593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 139 QLSGMQISGAVAPAPPSSGLGfgPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPAS 218
Cdd:PHA03378 594 QTPWPVPHPSQTPEPPTTQSH--IPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGH 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 219 GgPRLPSMTGP--LLPGQSfgGPSVSQPNHVS---SPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQ 293
Cdd:PHA03378 672 I-PYQPSPTGAntMLPIQW--APGTMQPPPRAptpMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPA 748
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 257051070 294 SNYGGPYP--AAPTFGSQPGPPQPLPPKRLDPDAIPSPIQ 331
Cdd:PHA03378 749 AAPGRARPpaAAPGRARPPAAAPGAPTPQPPPQAPPAPQQ 788
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
14-298 |
4.36e-04 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 44.55 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 14 GQPQP-IYPGYHQSSYGGQSGSTaPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQA--PCGQAAYGQFGQGD 90
Cdd:pfam03157 276 GQGQQgYYPTSLQQPGQGQSGYY-PTSQQQAGQLQQEQQLGQEQQDQQPGQGRQGQQPGQGQQGqqPAQGQQPGQGQPGY 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 91 VQNGPSSTVQMQrlPGSQPfGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAP-----APPSSGLG---FGP 162
Cdd:pfam03157 355 YPTSPQQPGQGQ--PGYYP-TSQQQPQQGQQPEQGQQGQQQGQGQQGQQPGQGQQPGQGQPgyyptSPQQSGQGqpgYYP 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 163 PTSLASASGSFPNSGLY---GSYPQGQAPPLSQAQGHPGiQTPQRSAPSQASSFTPPASggprlPSMTGPLLPGQSFGGP 239
Cdd:pfam03157 432 TSPQQSGQGQQPGQGQQpgqEQPGQGQQPGQGQQGQQPG-QPEQGQQPGQGQPGYYPTS-----PQQSGQGQQLGQWQQQ 505
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 257051070 240 SVSQPNHVSSPPQALPPGTQMTGPLGPLPPmhspqqpGYQPQQNGSFGPARGPQSNYGG 298
Cdd:pfam03157 506 GQGQPGYYPTSPLQPGQGQPGYYPTSPQQP-------GQGQQLGQLQQPTQGQQGQQSG 557
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
5-250 |
4.58e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.69 E-value: 4.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 5 QSVPPVPPFGQPQPIY------PGYHQSSYGGQSGSTAPAIPYGAYNGPVPGyQQTPPQGMSRAPPSSGAPPASTAQAPC 78
Cdd:PRK10263 378 EGYPQQSQYAQPAVQYneplqqPVQPQQPYYAPAAEQPAQQPYYAPAPEQPA-QQPYYAPAPEQPVAGNAWQAEEQQSTF 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 79 GQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQppvLQPYGPP--------PTSAQVATQLSGMQisgAVA 150
Cdd:PRK10263 457 APQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEE---TKPARPPlyyfeeveEKRAREREQLAAWY---QPI 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 151 PAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPqgQAPPLSQAQGHPGIqtpqrSAPSQASSFTPPASGGPRLPSMTGPl 230
Cdd:PRK10263 531 PEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSP--LASGVKKATLATGA-----AATVAAPVFSLANSGGPRPQVKEGI- 602
|
250 260
....*....|....*....|
gi 257051070 231 lpgqsfgGPSVSQPNHVSSP 250
Cdd:PRK10263 603 -------GPQLPRPKRIRVP 615
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
4-344 |
5.22e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 44.21 E-value: 5.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 4 NQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPygayngPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAY 83
Cdd:PRK07764 429 PQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ------PAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAA 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 84 GQFGQGDVQ------------NGPSSTVQMQRLPGSQPfgsplapVGNQPPVLQPYGPPPTSAQ--------------VA 137
Cdd:PRK07764 503 PAGADDAATlrerwpeilaavPKRSRKTWAILLPEATV-------LGVRGDTLVLGFSTGGLARrfaspgnaevlvtaLA 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 138 TQLSG-MQISGAVAPAPPSSGlGFGPPTSLASASGSFPNSglygsyPQGQAPPLSQAQGHPGiQTPQRSAPSQASSFTPP 216
Cdd:PRK07764 576 EELGGdWQVEAVVGPAPGAAG-GEGPPAPASSGPPEEAAR------PAAPAAPAAPAAPAPA-GAAAAPAEASAAPAPGV 647
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 217 ASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYqpqqngsfgPARGPQSNY 296
Cdd:PRK07764 648 AAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATP---------PAGQADDPA 718
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 257051070 297 GGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGTEP 344
Cdd:PRK07764 719 AQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAP 766
|
|
| hnRNP-R-Q |
TIGR01648 |
heterogeneous nuclear ribonucleoprotein R, Q family; Sequences in this subfamily include the ... |
12-193 |
6.41e-04 |
|
heterogeneous nuclear ribonucleoprotein R, Q family; Sequences in this subfamily include the human heterogeneous nuclear ribonucleoproteins (hnRNP) R, Q, and APOBEC-1 complementation factor (aka APOBEC-1 stimulating protein). These proteins contain three RNA recognition domains (rrm: pfam00076) and a somewhat variable C-terminal domain.
Pssm-ID: 273732 [Multi-domain] Cd Length: 578 Bit Score: 43.84 E-value: 6.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 12 PFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYngpVPGYQQTPPQGMSRAPPSSGAPPASTAQapcgqaaYGQFGQGdv 91
Cdd:TIGR01648 383 GRGYPPYGYEAYYGDYYGYHDYRGKYEDKYYGY---DPGMELTPMNPVRGKPGGRGGRPAIPPP-------RGRKNGA-- 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 92 qnGPSSTVQMQRLPGSQPFGSPLApvGNQPPVLQPYGPPPTSAQVatqlsgmqiSGAVAPAPPSSGLGFGPPTSlaSASG 171
Cdd:TIGR01648 451 --PPPAIGQDGRQLFLYKITIPAG--YSQRPAPHPLGPPRGSAFV---------RGARGGPAQYQQRGRGSRTS--RGNG 515
|
170 180
....*....|....*....|..
gi 257051070 172 SFPNSGLYGSYPQGQAPPLSQA 193
Cdd:TIGR01648 516 RGGTAGGKRKAFDGYAQPDATA 537
|
|
| dermokine |
cd21118 |
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ... |
27-262 |
7.04e-04 |
|
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.
Pssm-ID: 411053 [Multi-domain] Cd Length: 495 Bit Score: 43.45 E-value: 7.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 27 SYGGQSGSTApaipYGAYNGPvpGYQQTPPQGMSRAPPSSGAPPASTAQApcgqAAYGQFGQGDVQNGPSSTvqmqrlPG 106
Cdd:cd21118 120 SWQGSGGHGA----YGSQGGP--GVQGHGIPGGTGGPWASGGNYGTNSLG----GSVGQGGNGGPLNYGTNS------QG 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 107 SQPFGSPLAPVGNQppvlQPYG---PPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGS-------FPNS 176
Cdd:cd21118 184 AVAQPGYGTVRGNN----QNSGctnPPPSGSHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNggnngssSSNS 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 177 GLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSqASSFTPPASGGPRLPSMTGPllpgqsfgGPSVSQPNHVSSPPQALPP 256
Cdd:cd21118 260 GNSGGSNGGSSGNSGSGSGGSSSGGSNGWGGS-SSSGGSGGSGGGNKPECNNP--------GNDVRMAGGGGSQGSKESS 330
|
....*.
gi 257051070 257 GTQMTG 262
Cdd:cd21118 331 GSHGSN 336
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
8-269 |
8.53e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 8.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 8 PPVPPFGQPQPIYPGYHQSSYGGQSGStaPAIPYGAYNGPVPGyqqtppqGMSRAPPSSGAPPASTAQAP-CGQAAYGQF 86
Cdd:PHA03307 185 APSSPPAEPPPSTPPAAASPRPPRRSS--PISASASSPAPAPG-------RSAADDAGASSSDSSSSESSgCGWGPENEC 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 87 GQGDVQNGPSSTVQMQRLPG---------SQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPA---PP 154
Cdd:PHA03307 256 PLPRPAPITLPTRIWEASGWngpssrpgpASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSsssES 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 155 SSGLGFGPPTSLASASGSFPNSGlygsyPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQ 234
Cdd:PHA03307 336 SRGAAVSPGPSPSRSPSPSRPPP-----PADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAG 410
|
250 260 270
....*....|....*....|....*....|....*...
gi 257051070 235 SFGGPSVSQPNHVSSPPQALPPGTQMTGPL---GPLPP 269
Cdd:PHA03307 411 RPRPSPLDAGAASGAFYARYPLLTPSGEPWpgsPPPPP 448
|
|
| PRK14959 |
PRK14959 |
DNA polymerase III subunits gamma and tau; Provisional |
146-255 |
1.30e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 42.74 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 146 SGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAqghPGIQTPQRSAPSqassfTPPASGGPRLPS 225
Cdd:PRK14959 382 SGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAA---PSPRVPWDDAPP-----APPRSGIPPRPA 453
|
90 100 110
....*....|....*....|....*....|
gi 257051070 226 mtgPLLPGQSfggPSVSQPNHVSSPPQALP 255
Cdd:PRK14959 454 ---PRMPEAS---PVPGAPDSVASASDAPP 477
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
28-164 |
1.35e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 28 YGGQSGSTAPAIPYGAYNGPVPgyqqTPPQGMSRAPPSSGAPPASTAQAPCGQAAygqfgqgdvqnGPSSTVQMQRLPGS 107
Cdd:PRK07764 387 VAGGAGAPAAAAPSAAAAAPAA----APAPAAAAPAAAAAPAPAAAPQPAPAPAP-----------APAPPSPAGNAPAG 451
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 257051070 108 QPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPT 164
Cdd:PRK07764 452 GAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADD 508
|
|
| SPT5 |
COG5164 |
Transcription elongation factor SPT5 [Transcription]; |
87-269 |
1.80e-03 |
|
Transcription elongation factor SPT5 [Transcription];
Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 42.32 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 87 GQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPvlqpygppptsAQVATQLSGMQISGAVAPAPPSSGlgfGPPTSL 166
Cdd:COG5164 3 LYGPGKTGPSDPGGVTTPAGSQGSTKPAQNQGSTRP-----------AGNTGGTRPAQNQGSTTPAGNTGG---TRPAGN 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 167 ASASGSFPNSGlygsypqGQAPPlsqaqGHPGIQTPqrsaPSQASSFTPPASGGPrlpsmTGPLLPGQSFGGP----SVS 242
Cdd:COG5164 69 QGATGPAQNQG-------GTTPA-----QNQGGTRP----AGNTGGTTPAGDGGA-----TGPPDDGGATGPPddggSTT 127
|
170 180 190
....*....|....*....|....*....|.
gi 257051070 243 QPNHVSSPPQ----ALPPGTQMTGPLGPLPP 269
Cdd:COG5164 128 PPSGGSTTPPgdggSTPPGPGSTGPGGSTTP 158
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
8-307 |
1.93e-03 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 42.24 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 8 PPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQT---PPQGMSRAPPSSGAP---PASTAQAPCGQ- 80
Cdd:pfam03157 419 PQQSGQGQPGYYPTSPQQSGQGQQPGQGQQPGQEQPGQGQQPGQGQQgqqPGQPEQGQQPGQGQPgyyPTSPQQSGQGQq 498
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 81 -AAYGQFGQGDVQNGPSSTVQM-QRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGL 158
Cdd:pfam03157 499 lGQWQQQGQGQPGYYPTSPLQPgQGQPGYYPTSPQQPGQGQQLGQLQQPTQGQQGQQSGQGQQGQQPGQGQQGQQPGQGQ 578
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 159 GFGPPtslasASGSFPNSGLYGSYP-------QGQAPPLSQ--AQGHPGIQTPQRSAPSQASSFTPPAS----GGPRLPS 225
Cdd:pfam03157 579 QGQQP-----GQGQQPGQGQPGYYPtspqqsgQGQQPGQWQqpGQGQPGYYPTSSLQLGQGQQGYYPTSpqqpGQGQQPG 653
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 226 MTGPLLPGQSFGGP-------SVSQPNHVSSPPQALPPGTQMTG--PLGPLPPmhspqqpGYQPQQNGSFGPARGPQsny 296
Cdd:pfam03157 654 QWQQSGQGQQGYYPtspqqsgQAQQPGQGQQPGQWLQPGQGQQGyyPTSPQQP-------GQGQQLGQGQQSGQGQQ--- 723
|
330
....*....|.
gi 257051070 297 gGPYPAAPTFG 307
Cdd:pfam03157 724 -GYYPTSPGQG 733
|
|
| SP6_N |
cd22544 |
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins ... |
105-266 |
2.00e-03 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP6, also known as epiprofin, shows specific expression pattern in hair follicles and the apical ectodermal ridge (AER) of the developing limbs. SP6 null mice are nude and show defects in skin, teeth, limbs (syndactyly and oligodactyly), and lung alveoli. SP6 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP6.
Pssm-ID: 411693 [Multi-domain] Cd Length: 245 Bit Score: 41.06 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 105 PGSQPFGSPlAPVGNQPpvLQPYGPPPTSAQVATQLSGMQISGAVAPAPP----SSGLGFGPPTSLASASGSFPNSGLyG 180
Cdd:cd22544 13 HSETPRASP-PTLDLQP--LQPYQIHSSPEAGDYPSPLQPTELQSLPLGPgvdfSARESYEPHSSRRTCLDLESDLPL-G 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 181 SYPQGQAPPLSQAQ--------GHPGIQTPQRSAPS-----QASSFT--PPASGGPRLPSMTGPLLPGQsfgGPSVSQPN 245
Cdd:cd22544 89 PFPKLLHPPPDMAHpyeswfrpPHPGGSGEEGGVPSwwdlhAGSSWMdlQHGQGGLQSPGPPGGLQPPL---GGYGSEHQ 165
|
170 180
....*....|....*....|.
gi 257051070 246 HVSSPPQALPPGTQMTGPLGP 266
Cdd:cd22544 166 LCGPPHHLLPPAQHLMGQEGP 186
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
129-308 |
2.63e-03 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 41.42 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 129 PPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPS 208
Cdd:COG5651 166 PFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAAGAAAAAA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 209 QASSF-TPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFG 287
Cdd:COG5651 246 AAAAAaGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAG 325
|
170 180
....*....|....*....|.
gi 257051070 288 PARGPQSNYGGPYPAAPTFGS 308
Cdd:COG5651 326 AALGAGAAAAAAGAAAGAGAA 346
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
3-220 |
2.94e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.79 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 3 VNQSVPPV--PPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQ 80
Cdd:PRK12323 382 VAQPAPAAaaPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 81 ---AAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPlaPVGNQPPVLQPYGPPPTsaqvatqlsgmqisgavAPAPPSSG 157
Cdd:PRK12323 462 arpAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP--PWEELPPEFASPAPAQP-----------------DAAPAGWV 522
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257051070 158 LGFGPPTSLASASGSFPNSGlygsyPQGQAPPLSQAQGHPGIQTPQRsAPSQASSFTPPASGG 220
Cdd:PRK12323 523 AESIPDPATADPDDAFETLA-----PAPAAAPAPRAAAATEPVVAPR-PPRASASGLPDMFDG 579
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
67-269 |
3.46e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.40 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 67 GAPPASTAQAPCGQAAYGQFGQGDVQNGPSStvqmqrlPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQIS 146
Cdd:PRK12323 371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAA-------PPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 147 GAVAPAPPSSglgfgPPTSLASAsgsfpnsglygsypqgQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGP---RL 223
Cdd:PRK12323 444 PGGAPAPAPA-----PAAAPAAA----------------ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPpweEL 502
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 257051070 224 PSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPP 269
Cdd:PRK12323 503 PPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA 548
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
103-239 |
3.78e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.51 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 103 RLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLgfGPPTSLASASGSFPNSGLYGSY 182
Cdd:PRK07764 380 RLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAP--APAPAPPSPAGNAPAGGAPSPP 457
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 257051070 183 PQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASggPRLPSMTGPLLPGQSFGGP 239
Cdd:PRK07764 458 PAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA--PAAPAAPAAPAGADDAATL 512
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
132-268 |
5.05e-03 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 40.23 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 132 TSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASAsGSFPNSGLYGSY-----PQGQAP-PLSQAQGHPGIQTPQRS 205
Cdd:PHA02682 21 TSSSLFTKCPQATIPAPAAPCPPDADVDPLDKYSVKEA-GRYYQSRLKANSacmqrPSGQSPlAPSPACAAPAPACPACA 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257051070 206 APSQASSFTPPASgGPRLPSMTGPLLPgqsfggPSVSQPNHvSSPPQALPPGTQMTGPLGPLP 268
Cdd:PHA02682 100 PAAPAPAVTCPAP-APACPPATAPTCP------PPAVCPAP-ARPAPACPPSTRQCPPAPPLP 154
|
|
| DUF4645 |
pfam15488 |
Domain of unknown function (DUF4645); This family of proteins is found in eukaryotes. Proteins ... |
116-305 |
5.72e-03 |
|
Domain of unknown function (DUF4645); This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 298 amino acids in length.
Pssm-ID: 406050 [Multi-domain] Cd Length: 294 Bit Score: 40.23 E-value: 5.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 116 PVGNQPPVLQPYGPPPTSAQ--VATQ-------LSG--------MQISGAVAPAPPSSGLGfGPPTSLASASGSFPNSGL 178
Cdd:pfam15488 82 PVDSSRALRHPYGPPPAVAEesLATAevnssegLAGwrqkgqdsINVSQEFSGSPPALMVG-GTRVSNGGTERGGNNAKL 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 179 YGSYPQGQA---PPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLlpgqsfGGPSvsqpNHVSSPPQALP 255
Cdd:pfam15488 161 YSALPRGQGffpPRGPQVRGPPHIPTLRSGIMMEVPPGNTRMAGKERLAHVSFPL------GGPR----HPMDNWPRPIP 230
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 257051070 256 PGTQMTGpLGPLPPMHspqqpgyqpqqngSFGPARGPQSNyggPYPAAPT 305
Cdd:pfam15488 231 LSSSTPG-LPSCSTAH-------------CFIPPRPPSFN---PFLAMPI 263
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
94-222 |
7.71e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.35 E-value: 7.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 94 GPSSTVQMQRLPGSQPFGSPLAPvgnqPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSF 173
Cdd:PRK07764 389 GGAGAPAAAAPSAAAAAPAAAPA----PAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSA 464
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 257051070 174 PnsglygSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPR 222
Cdd:PRK07764 465 Q------PAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
14-297 |
7.97e-03 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 40.32 E-value: 7.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 14 GQPQPIYPGYHQSSYGGQSGstapaipYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYG-----QFGQ 88
Cdd:pfam03157 124 GQASPQRPGQGQQPGQGQQW-------YYPTSPQQPGQWQQPGQGQQGYYPTSPQQSGQRQQPGQGQQLRQgqqgqQSGQ 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 89 GDVQNGPSSTVQMQRLP----GSQPFGSPLAPVGNQP-----PVLQPYGPPPTSAQVATQlsGMQISGAVAPAPPSSGLG 159
Cdd:pfam03157 197 GQPGYYPTSSQQPGQLQqtgqGQQGQQPERGQQGQQPgqgqqPGQGQQGQQPGQPQQLGQ--GQQGYYPISPQQPRQWQQ 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257051070 160 FGP------PTSLASasgsfPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLlPG 233
Cdd:pfam03157 275 SGQgqqgyyPTSLQQ-----PGQGQSGYYPTSQQQAGQLQQEQQLGQEQQDQQPGQGRQGQQPGQGQQGQQPAQGQQ-PG 348
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 257051070 234 QSfggpsvsQPNHVSSPPQALPPGTQMTGPlgplppmhspqqpgyqpQQNGSfgPARGPQSNYG 297
Cdd:pfam03157 349 QG-------QPGYYPTSPQQPGQGQPGYYP-----------------TSQQQ--PQQGQQPEQG 386
|
|
| |
