NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|308153573|sp|P55159|]
View 

RecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=Serum aryldialkylphosphatase 1

Protein Classification

strictosidine synthase family protein( domain architecture ID 10484254)

strictosidine synthase family protein with similarity to strictosidine synthase that catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 8.65e-46

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


:

Pssm-ID: 334656  Cd Length: 86  Bit Score: 151.08  E-value: 8.65e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153573  168 NDIAAVGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVRVVADGFDFANGIGISLDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 308153573  248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 8.65e-46

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 151.08  E-value: 8.65e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153573  168 NDIAAVGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVRVVADGFDFANGIGISLDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 308153573  248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 166-308 2.15e-15

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 75.31  E-value: 2.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153573 166 SINDIAaVGPE-SFYATNdhyfadpylrsweMYLGLSWSNVVYYSPD-KVRVVADGFDFANGIGISLDGKYVYIAELLAH 243
Cdd:COG3386   94 RPNDGV-VDPDgRLYFTD-------------MGEYLPTGALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAG 159

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 308153573 244 KIHVYEKHANWTLTPLKVL----SFDTLVDNISVDpVTGDLWVgCHPNGMRIFFYDsenPPGSEVLRIQ 308
Cdd:COG3386  160 RIYRFDLDADGTLGNRRVFadlpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFD---PDGELLGRIE 223
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 8.65e-46

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 151.08  E-value: 8.65e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153573  168 NDIAAVGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVRVVADGFDFANGIGISLDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 308153573  248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 166-308 2.15e-15

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 75.31  E-value: 2.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153573 166 SINDIAaVGPE-SFYATNdhyfadpylrsweMYLGLSWSNVVYYSPD-KVRVVADGFDFANGIGISLDGKYVYIAELLAH 243
Cdd:COG3386   94 RPNDGV-VDPDgRLYFTD-------------MGEYLPTGALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAG 159

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 308153573 244 KIHVYEKHANWTLTPLKVL----SFDTLVDNISVDpVTGDLWVgCHPNGMRIFFYDsenPPGSEVLRIQ 308
Cdd:COG3386  160 RIYRFDLDADGTLGNRRVFadlpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFD---PDGELLGRIE 223
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 137-308 5.43e-07

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 49.95  E-value: 5.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153573  137 SSSTVEVFKFQEEERSLLHLKTITHELLPSINDiAAVGPE-SFYATNDHYFADPylrswemylGLSWSNVVYYSPD-KVR 214
Cdd:pfam08450  58 LKDGVALLDLATGELTPLADPEDDDWPLNRFND-GKVDPDgRFWFGTMGDDEAP---------GGDPGALYRLDPDgKLT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153573  215 VVADGFDFANGIGISLDGKYVYIAELLAHKIHVYEKHA-NWTLTPLKVLS----FDTLVDNISVDPvTGDLWVgCHPNGM 289
Cdd:pfam08450 128 RVLDGLTISNGLAWSPDGRTLYFADSPARKIWAYDYDLdGGLISNRRVFAdfkpGLGRPDGMAVDA-EGNVWV-ARWGGG 205

                         170
                  ....*....|....*....
gi 308153573  290 RIFFYDsenPPGSEVLRIQ 308
Cdd:pfam08450 206 KVVRFD---PDGKLLREIE 221
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 179-248 3.11e-03

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 36.26  E-value: 3.11e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308153573  179 YATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDK--VRVVADGFDFANGIGISLDGKYVYIAELLAHKIHVY 248
Cdd:pfam03088  13 YFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTkvTKVLLDDLYFPNGIALSPDGSFVLFCETPMARISRY 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH