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Conserved domains on  [gi|1706526|sp|P55292|]
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RecName: Full=Desmocollin-2; AltName: Full=Epithelial type 2 desmocollin; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-111 1.30e-29

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 214999  Cd Length: 87  Bit Score: 112.76  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526      31 ACKEVVLQVPSELPAEKFVGRVNLMDCLKSADIV-HLSDPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREI 109
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQfESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 1706526     110 SV 111
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-351 9.34e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 9.34e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  248 YSFTVQENSRIGSIVGEVCATDLDEPdtMHTRLRYSILeqSPSPPMLFTMHPSTGVITTTSAqLDRELIDKYQLLIKVQD 327
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIV--SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 1706526  328 MDGQyfGLHTTAKCIITIEDVNDN 351
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
360-447 5.93e-17

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    360 YVTSVEENT-VNVEILRLTVQDKDLvnSPNWRANYTILKGNENGNFKIVTDPktneGILCVIKPLDYEERQQVTLQIGVV 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 1706526    439 NEAPYTREA 447
Cdd:pfam00028  75 DSGGPPLSS 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 1.81e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.81e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  477 TVRIQENVPVGTR--NdgYKAYDPETRSSSGIRYRKLS-DPRGWVTVNEDSGSITIFRALDREAetvrNGIYNITVLALD 553
Cdd:cd11304   3 EVSVPENAPPGTVvlT--VSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 1706526  554 ADG--RSCTGTLGIILEDVNDN 573
Cdd:cd11304  77 GGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
140-234 3.90e-15

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    140 IPCSMLENSL-GPFPLFLQQIQSDTAQNYTIYYSIRGPGVDkeplNLFYVERDTGNLYCTGRVDREQYESFELTAFATTP 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1706526    219 DGYTPEYPLPLLIKIE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CADH_Y-type_LIR super family cl03079
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 853-900 2.21e-06

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


The actual alignment was detected with superfamily member pfam01049:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 45.61  E-value: 2.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1706526    853 DYVLTYNYEGKGSAAG---SVGCCSDLQEEDgLEFLDHLEPKFRTLAEVCA 900
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAELYG 60
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-669 1.33e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 38.82  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    594 IVAVDLDDPVNGPPFdFSLesSDSEVQRMWRLTRIND---TAARLSYqndPSFGSYAVPIRVTDRL--GLSSVTTLNVLV 668
Cdd:pfam00028  18 VTATDPDLGPNGRIF-YSI--LGGGPGGNFRIDPDTGdisTTKPLDR---ESIGEYELTVEATDSGgpPLSSTATVTITV 91


                  .
gi 1706526    669 C 669
Cdd:pfam00028  92 L 92
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-111 1.30e-29

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 112.76  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526      31 ACKEVVLQVPSELPAEKFVGRVNLMDCLKSADIV-HLSDPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREI 109
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQfESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 1706526     110 SV 111
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-351 9.34e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 9.34e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  248 YSFTVQENSRIGSIVGEVCATDLDEPdtMHTRLRYSILeqSPSPPMLFTMHPSTGVITTTSAqLDRELIDKYQLLIKVQD 327
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIV--SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 1706526  328 MDGQyfGLHTTAKCIITIEDVNDN 351
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-346 7.40e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 7.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    248 YSFTVQENSRIGSIVGEVCATDLDEPDtmHTRLRYSILEQSPSPpmLFTMHPSTGVITTTsAQLDRELIDKYQLLIKVQD 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGGGPGG--NFRIDPDTGDISTT-KPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*....
gi 1706526    328 MDGQyfGLHTTAKCIITIE 346
Cdd:pfam00028  76 SGGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-353 2.19e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 2.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526     267 ATDLDEPDtmHTRLRYSILEQSPSPPmlFTMHPSTGVITTTsAQLDRELIDKYQLLIKVQDMDGQyfGLHTTAKCIITIE 346
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGL--FSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1706526     347 DVNDNLP 353
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
360-447 5.93e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    360 YVTSVEENT-VNVEILRLTVQDKDLvnSPNWRANYTILKGNENGNFKIVTDPktneGILCVIKPLDYEERQQVTLQIGVV 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 1706526    439 NEAPYTREA 447
Cdd:pfam00028  75 DSGGPPLSS 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 1.81e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.81e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  477 TVRIQENVPVGTR--NdgYKAYDPETRSSSGIRYRKLS-DPRGWVTVNEDSGSITIFRALDREAetvrNGIYNITVLALD 553
Cdd:cd11304   3 EVSVPENAPPGTVvlT--VSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 1706526  554 ADG--RSCTGTLGIILEDVNDN 573
Cdd:cd11304  77 GGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
476-568 2.69e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    476 QTVRIQENVPVGTRNDGYKAYDPETRSSSGIRYRKLSD-PRGWVTVNEDSGSITIFRALDREAetvrNGIYNITVLALDA 554
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1706526    555 D--GRSCTGTLGIILE 568
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-234 3.90e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    140 IPCSMLENSL-GPFPLFLQQIQSDTAQNYTIYYSIRGPGVDkeplNLFYVERDTGNLYCTGRVDREQYESFELTAFATTP 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1706526    219 DGYTPEYPLPLLIKIE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 359-450 5.34e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 5.34e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  359 TYVTSVEENT-VNVEILRLTVQDKDLvnSPNWRANYTILKGNENGNFKIvtDPKTneGILCVIKPLDYEERQQVTLQIGV 437
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90
                ....*....|...
gi 1706526  438 VNEAPYTREASSK 450
Cdd:cd11304  75 TDGGGPPLSSTAT 87
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 1.12e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526     494 KAYDPETRSSSGIRYRKLS-DPRGWVTVNEDSGSITIFRALDREAETVrngiYNITVLALDADG--RSCTGTLGIILEDV 570
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPE----YTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 1706526     571 NDNGP 575
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-241 9.92e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 9.92e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526     161 SDTAQNYTIYYSIRGPGVDkeplNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDNY 240
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1706526     241 P 241
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-239 1.45e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.45e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706526  162 DTAQNYTIYYSIRGPGvdkePLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDN 239
Cdd:cd11304  25 DSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-449 6.95e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 6.95e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706526     377 TVQDKDLvnSPNWRANYTILKGNENGNFKIvtDPKTneGILCVIKPLDYEERQQVTLQIGVVNEAPYTREASS 449
Cdd:smart00112   1 SATDADS--GENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 853-900 2.21e-06

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 45.61  E-value: 2.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1706526    853 DYVLTYNYEGKGSAAG---SVGCCSDLQEEDgLEFLDHLEPKFRTLAEVCA 900
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAELYG 60
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 39-111 6.34e-06

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 45.39  E-value: 6.34e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1706526     39 VPSELPAEKFVGRVNLMDCLKSADIVHLS-DPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREISV 111
Cdd:pfam08758  15 VPRRLEEGQPLLNVKFNDCTGRKKTLYESsDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKV 88
Cadherin pfam00028
Cadherin domain;
594-669 1.33e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.82  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    594 IVAVDLDDPVNGPPFdFSLesSDSEVQRMWRLTRIND---TAARLSYqndPSFGSYAVPIRVTDRL--GLSSVTTLNVLV 668
Cdd:pfam00028  18 VTATDPDLGPNGRIF-YSI--LGGGPGGNFRIDPDTGdisTTKPLDR---ESIGEYELTVEATDSGgpPLSSTATVTITV 91


                  .
gi 1706526    669 C 669
Cdd:pfam00028  92 L 92
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-111 1.30e-29

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 112.76  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526      31 ACKEVVLQVPSELPAEKFVGRVNLMDCLKSADIV-HLSDPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREI 109
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQfESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 1706526     110 SV 111
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-351 9.34e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 9.34e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  248 YSFTVQENSRIGSIVGEVCATDLDEPdtMHTRLRYSILeqSPSPPMLFTMHPSTGVITTTSAqLDRELIDKYQLLIKVQD 327
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIV--SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 1706526  328 MDGQyfGLHTTAKCIITIEDVNDN 351
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-346 7.40e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 7.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    248 YSFTVQENSRIGSIVGEVCATDLDEPDtmHTRLRYSILEQSPSPpmLFTMHPSTGVITTTsAQLDRELIDKYQLLIKVQD 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGGGPGG--NFRIDPDTGDISTT-KPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*....
gi 1706526    328 MDGQyfGLHTTAKCIITIE 346
Cdd:pfam00028  76 SGGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-353 2.19e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 2.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526     267 ATDLDEPDtmHTRLRYSILEQSPSPPmlFTMHPSTGVITTTsAQLDRELIDKYQLLIKVQDMDGQyfGLHTTAKCIITIE 346
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGL--FSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1706526     347 DVNDNLP 353
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
360-447 5.93e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    360 YVTSVEENT-VNVEILRLTVQDKDLvnSPNWRANYTILKGNENGNFKIVTDPktneGILCVIKPLDYEERQQVTLQIGVV 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 1706526    439 NEAPYTREA 447
Cdd:pfam00028  75 DSGGPPLSS 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 1.81e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.81e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  477 TVRIQENVPVGTR--NdgYKAYDPETRSSSGIRYRKLS-DPRGWVTVNEDSGSITIFRALDREAetvrNGIYNITVLALD 553
Cdd:cd11304   3 EVSVPENAPPGTVvlT--VSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 1706526  554 ADG--RSCTGTLGIILEDVNDN 573
Cdd:cd11304  77 GGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
476-568 2.69e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    476 QTVRIQENVPVGTRNDGYKAYDPETRSSSGIRYRKLSD-PRGWVTVNEDSGSITIFRALDREAetvrNGIYNITVLALDA 554
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1706526    555 D--GRSCTGTLGIILE 568
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-234 3.90e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    140 IPCSMLENSL-GPFPLFLQQIQSDTAQNYTIYYSIRGPGVDkeplNLFYVERDTGNLYCTGRVDREQYESFELTAFATTP 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1706526    219 DGYTPEYPLPLLIKIE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 359-450 5.34e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 5.34e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  359 TYVTSVEENT-VNVEILRLTVQDKDLvnSPNWRANYTILKGNENGNFKIvtDPKTneGILCVIKPLDYEERQQVTLQIGV 437
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90
                ....*....|...
gi 1706526  438 VNEAPYTREASSK 450
Cdd:cd11304  75 TDGGGPPLSSTAT 87
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 1.12e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526     494 KAYDPETRSSSGIRYRKLS-DPRGWVTVNEDSGSITIFRALDREAETVrngiYNITVLALDADG--RSCTGTLGIILEDV 570
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPE----YTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 1706526     571 NDNGP 575
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-241 9.92e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 9.92e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526     161 SDTAQNYTIYYSIRGPGVDkeplNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDNY 240
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1706526     241 P 241
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-239 1.45e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.45e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706526  162 DTAQNYTIYYSIRGPGvdkePLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDN 239
Cdd:cd11304  25 DSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-239 6.62e-10

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 56.97  E-value: 6.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526  140 IPCSMLENSLGPfpLFLQQIQSDTAQNYTIYYSIRGPGVDKePLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPD 219
Cdd:cd00031   2 PDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEA-LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                        90       100
                ....*....|....*....|
gi 1706526  220 GYTPEYPLPLLIKIEDENDN 239
Cdd:cd00031  79 ANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-449 6.95e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 6.95e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706526     377 TVQDKDLvnSPNWRANYTILKGNENGNFKIvtDPKTneGILCVIKPLDYEERQQVTLQIGVVNEAPYTREASS 449
Cdd:smart00112   1 SATDADS--GENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 853-900 2.21e-06

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 45.61  E-value: 2.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1706526    853 DYVLTYNYEGKGSAAG---SVGCCSDLQEEDgLEFLDHLEPKFRTLAEVCA 900
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAELYG 60
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 39-111 6.34e-06

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 45.39  E-value: 6.34e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1706526     39 VPSELPAEKFVGRVNLMDCLKSADIVHLS-DPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREISV 111
Cdd:pfam08758  15 VPRRLEEGQPLLNVKFNDCTGRKKTLYESsDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKV 88
Cadherin pfam00028
Cadherin domain;
594-669 1.33e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.82  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706526    594 IVAVDLDDPVNGPPFdFSLesSDSEVQRMWRLTRIND---TAARLSYqndPSFGSYAVPIRVTDRL--GLSSVTTLNVLV 668
Cdd:pfam00028  18 VTATDPDLGPNGRIF-YSI--LGGGPGGNFRIDPDTGdisTTKPLDR---ESIGEYELTVEATDSGgpPLSSTATVTITV 91


                  .
gi 1706526    669 C 669
Cdd:pfam00028  92 L 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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