NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|38372286|sp|P60014|]
View 

RecName: Full=Keratin-associated protein 10-10; AltName: Full=High sulfur keratin-associated protein 10.10; AltName: Full=Keratin-associated protein 10.10; AltName: Full=Keratin-associated protein 18-10; AltName: Full=Keratin-associated protein 18.10

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 135-251 1.45e-05

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.01  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372286   135 TCCTSSPCQQACCVPVCSKSVCYVPVCSGASTS---CCQQSSCQPAC---CTASCCRPSSSVSLLCHPVCKSTCCVPVPS 208
Cdd:pfam01500  13 TCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCqptTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 38372286   209 CGASASS---CQPSCCRTASCVSLLCRPVCSRPACYSLCSGQKSSC 251
Cdd:pfam01500  93 SGAVSSRtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCC 138
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 135-251 1.45e-05

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.01  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372286   135 TCCTSSPCQQACCVPVCSKSVCYVPVCSGASTS---CCQQSSCQPAC---CTASCCRPSSSVSLLCHPVCKSTCCVPVPS 208
Cdd:pfam01500  13 TCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCqptTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 38372286   209 CGASASS---CQPSCCRTASCVSLLCRPVCSRPACYSLCSGQKSSC 251
Cdd:pfam01500  93 SGAVSSRtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCC 138
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 135-251 1.45e-05

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.01  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372286   135 TCCTSSPCQQACCVPVCSKSVCYVPVCSGASTS---CCQQSSCQPAC---CTASCCRPSSSVSLLCHPVCKSTCCVPVPS 208
Cdd:pfam01500  13 TCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCqptTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 38372286   209 CGASASS---CQPSCCRTASCVSLLCRPVCSRPACYSLCSGQKSSC 251
Cdd:pfam01500  93 SGAVSSRtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCC 138
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 114-245 3.15e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 40.16  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372286   114 CFVPTCSESSPS---CCQQSSCQPTCCTSSPCQQACCVPVCSKSVCYVPVCSGA-STSCCQQSSCQPACCTASCC----- 184
Cdd:pfam01500   9 CGFPTCSTGGTCgsgCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCcQTSCCQPTCCQTSSCQTGCGgigyg 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38372286   185 -RPSSSVSLLCHPVCKSTCCVPVPSCGASA--SSCQPSCCRTASCVSLLCRPV-----CSRPACYSLCS 245
Cdd:pfam01500  89 qEGSSGAVSSRTRWCRPDCRVEGTCLPPCCvvSCTPPTCCQLHHAQASCCRPSycgqsCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
168-206 9.91e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.21  E-value: 9.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 38372286   168 CCQQSSCQPACCTASCCRPSSSVSLLCHPV-CKSTCCVPV 206
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPScCRPSCCRSS 40
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
165-206 1.12e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.82  E-value: 1.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 38372286   165 STSCCQQSSCQPACCTASCCRPSSSVSLLCHPVC-KSTCCVPV 206
Cdd:pfam13885   3 QPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCcRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 151-228 2.42e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.46  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372286   151 CSKSVCYVPVCSGAST---SCCQQSSCQPACCTASCCRPSSSVSLlchpVCKSTCCVPVPSCGASASSCQPSCCRTASCV 227
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTcgsGCCQPCCCQSSCCRPSCCQTSCCQPT----TFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQ 79


                  .
gi 38372286   228 S 228
Cdd:pfam01500  80 T 80
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
198-241 8.70e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 33.51  E-value: 8.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 38372286   198 CKSTCCVPVPScgaSASSCQPSCCRTASCVSLLCRPVCSRPACY 241
Cdd:pfam13885   2 CQPSCCQPSCC---QPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 74-244 9.08e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.92  E-value: 9.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372286    74 CYQQSSCQPDCCTSSPCQQACCVPVCCVPVCCVPVCNKPVCFVPTCSesspsccqqsscqpTCCTSSPCQQACCVPVCSK 153
Cdd:pfam01500  14 CSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ--------------PCCQTSCCQPTCCQTSSCQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372286   154 SVCyvpvcsgASTSCCQQSSCQPACCTASCCRPSSSVSLLCHPVCKSTCCVPVPSCgaSASSCQPSCCRTASCVSLLCRP 233
Cdd:pfam01500  80 TGC-------GGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCC--QLHHAQASCCRPSYCGQSCCRP 150

                         170
                  ....*....|.
gi 38372286   234 VCSRPACYSLC 244
Cdd:pfam01500 151 ACCCQCSEPTC 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH