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Conserved domains on  [gi|294862449|sp|P60411|]
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RecName: Full=Keratin-associated protein 10-9; AltName: Full=High sulfur keratin-associated protein 10.9; AltName: Full=Keratin-associated protein 10.9; AltName: Full=Keratin-associated protein 18-9; AltName: Full=Keratin-associated protein 18.9

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 78-246 1.98e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 72.13  E-value: 1.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449   78 SCCQQSSCQPAYC-TSSPCQQACCVPVCCKPVCCVPvccgasSCCQQSSYQPACCASSSCQPAC---CVPVCCKPVCCAP 153
Cdd:pfam01500   2 ACCGTSFCGFPTCsTGGTCGSGCCQPCCCQSSCCRP------SCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  154 TCSEDsySCCQQSSCQPACCTSSPCQQSYCVPVCCKPVCCKPICCVPVcsgasslCCQQSGCQPACCTTSCCRPSSSVSL 233
Cdd:pfam01500  76 SSCQT--GCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVS-------CTPPTCCQLHHAQASCCRPSYCGQS 146

                         170
                  ....*....|...
gi 294862449  234 LCRPVCRPACCVP 246
Cdd:pfam01500 147 CCRPACCCQCSEP 159
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 78-246 1.98e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 72.13  E-value: 1.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449   78 SCCQQSSCQPAYC-TSSPCQQACCVPVCCKPVCCVPvccgasSCCQQSSYQPACCASSSCQPAC---CVPVCCKPVCCAP 153
Cdd:pfam01500   2 ACCGTSFCGFPTCsTGGTCGSGCCQPCCCQSSCCRP------SCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  154 TCSEDsySCCQQSSCQPACCTSSPCQQSYCVPVCCKPVCCKPICCVPVcsgasslCCQQSGCQPACCTTSCCRPSSSVSL 233
Cdd:pfam01500  76 SSCQT--GCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVS-------CTPPTCCQLHHAQASCCRPSYCGQS 146

                         170
                  ....*....|...
gi 294862449  234 LCRPVCRPACCVP 246
Cdd:pfam01500 147 CCRPACCCQCSEP 159
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 78-246 1.98e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 72.13  E-value: 1.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449   78 SCCQQSSCQPAYC-TSSPCQQACCVPVCCKPVCCVPvccgasSCCQQSSYQPACCASSSCQPAC---CVPVCCKPVCCAP 153
Cdd:pfam01500   2 ACCGTSFCGFPTCsTGGTCGSGCCQPCCCQSSCCRP------SCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  154 TCSEDsySCCQQSSCQPACCTSSPCQQSYCVPVCCKPVCCKPICCVPVcsgasslCCQQSGCQPACCTTSCCRPSSSVSL 233
Cdd:pfam01500  76 SSCQT--GCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVS-------CTPPTCCQLHHAQASCCRPSYCGQS 146

                         170
                  ....*....|...
gi 294862449  234 LCRPVCRPACCVP 246
Cdd:pfam01500 147 CCRPACCCQCSEP 159
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 34-197 2.50e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 72.13  E-value: 2.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449   34 TSCCAPAPCLTLVCTPVSRVSSPCCQVTCEPSPCqsgctssCTPSCCQQSSCQPAYCTSSPCQ---QACCVPVCCKPVCC 110
Cdd:pfam01500   1 MACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSC-------CRPSCCQTSCCQPTTFQSSCCRptcQPCCQTSCCQPTCC 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  111 VPVCCGASSCC----QQSSYQPACCASSSCQPACCVPVCCKPVCCAPTCSedSYSCCQQSSCQPACCTSSPCQQSYCVPV 186
Cdd:pfam01500  74 QTSSCQTGCGGigygQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT--PPTCCQLHHAQASCCRPSYCGQSCCRPA 151

                         170
                  ....*....|.
gi 294862449  187 CCKPvCCKPIC 197
Cdd:pfam01500 152 CCCQ-CSEPTC 161
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-155 4.56e-13

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 65.58  E-value: 4.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449    4 STMSIRSSAYSDSWQVDDCPESCCEPPCCATSCCAPAPCLTLVCTPVSRVS--SPCCQVTC-EPSPCQSGCtssCTPSCC 80
Cdd:pfam01500  12 PTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCcqTSCCQPTCcQTSSCQTGC---GGIGYG 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 294862449   81 QQSSCQPAYCTSSPCQQACCVPVCCKPVCCVPVCCgASSCCQQSSYQPACCASSSCQPACCVPVCCKPvCCAPTC 155
Cdd:pfam01500  89 QEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT-PPTCCQLHHAQASCCRPSYCGQSCCRPACCCQ-CSEPTC 161
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 114-281 1.55e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 61.35  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  114 CCGASSCCQQSSYQPACCASSSCQPACCVPVCCKPVCCAPTCSEDSysCCQQSSCQPACctsspcqQSYCVPVCCKPVCC 193
Cdd:pfam01500   3 CCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPT--TFQSSCCRPTC-------QPCCQTSCCQPTCC 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  194 KPICCVPVCSGASSlcCQQSGCQPACCTTSCCRPSSSVSLLCRPVCRPACCVPVSscCAPTSSRQPSYCRQASCVSLLCR 273
Cdd:pfam01500  74 QTSSCQTGCGGIGY--GQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPT--CCQLHHAQASCCRPSYCGQSCCR 149


                  ....*...
gi 294862449  274 PVCSRPAC 281
Cdd:pfam01500 150 PACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
104-154 2.74e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 49.30  E-value: 2.74e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 294862449  104 CCKPVCCVPvccgasSCCQQSSYQPACCASSSCQPACCVPVCCKPVCCAPT 154
Cdd:pfam13885   1 CCQPSCCQP------SCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
162-202 9.92e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.38  E-value: 9.92e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 294862449  162 CCQQSSCQPACCTSSPCQQSYCVPVCCKPVCCKPICCVPVC 202
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
74-115 1.29e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.38  E-value: 1.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294862449   74 SCTPSCCQQSSCQPAYCTSSPCQQACCVPVCCKPVCCVPVCC 115
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 23-197 3.26e-07

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 49.43  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449   23 PESCCEPPCCATSCCAPAPCLTLVCTPVSRVSSPCCQVTCEPSPCQSGCT--SSCTPSCCQQSSCQPAYCTSSPCQQACC 100
Cdd:pfam05287   2 SYNCCSGNFSSRSLRNHLHYPVSSCGSSCPSNLSYSTDLCSPSSCQLGSSlrDNCQETCGEPTSCQTSSCEPCTSSTSYC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  101 VPVCCKPVCCVPVCCGASSCCQQSSYQPACCASSSCQPACCVPVCCKPVCCAPTCSEDSYscCQQSSCQPACCTSSPCQQ 180
Cdd:pfam05287  82 VPSPCQRSCYSPRTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLG--CLSKGFQSLGYGSSFCRP 159

                         170
                  ....*....|....*..
gi 294862449  181 SYCVPVCCKPVCCKPIC 197
Cdd:pfam05287 160 SYVSSRSYQPSCFRPSC 176
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
79-122 3.27e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.22  E-value: 3.27e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 294862449   79 CCQQSSCQPAYCTSSPCQQACCVPVCCKPVCCVPVCCgASSCCQ 122
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCC-RSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
161-201 3.99e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.84  E-value: 3.99e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 294862449  161 SCCQQSSCQPACCTSSPCQQSYCVPVCCKPVCCKPICCVPV 201
Cdd:pfam13885   5 SCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
72-113 4.11e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.84  E-value: 4.11e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294862449   72 TSSCTPSCCQQSSCQPAYCTSSPCQQACCVPVCCKPVCCVPV 113
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 10-145 1.25e-06

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 47.89  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449   10 SSAYSDSWQVDDCPESCCEPPCCATSCCAPAPCLTLVCTPV-SRVSSPCCQVTCEPSPCQsgcTSSCTPSCCQQSSCQPA 88
Cdd:pfam05287  44 SSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSpCQRSCYSPRTSCVCSPCQ---TTSAGSLGFGSSSCQSL 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 294862449   89 YCTSSPCQQACCVPVCCKPVCCVPVCCgASSCCQQSSYQPACCASSSCQPACCVPVC 145
Cdd:pfam05287 121 GYGSNSCQPLGCGSSGFRPLGCLSKGF-QSLGYGSSFCRPSYVSSRSYQPSCFRPSC 176
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
94-139 1.86e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.91  E-value: 1.86e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 294862449   94 PCQQACCVPVCCKPVCCVPVCCGaSSCCQQSSYQPACCASSSCQPA 139
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQ-PSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
209-254 7.37e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.67  E-value: 7.37e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 294862449  209 CCQQSGCQPACCTTSCCRPSSSVSLLCRPV-CRPACCVPvsSCCAPT 254
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPScCRPSCCRS--SCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 114-283 1.08e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 39.03  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  114 CCGASSCCQQSSYQPACCAS-SSCQPACCVPVCCKPVCCAPTCSEDSysCCQQSSCQPACCTSSPCQQSYCVPVCCKPVC 192
Cdd:pfam05287   3 YNCCSGNFSSRSLRNHLHYPvSSCGSSCPSNLSYSTDLCSPSSCQLG--SSLRDNCQETCGEPTSCQTSSCEPCTSSTSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294862449  193 CKPICCVPVCSGASSLC----CQQSGCQPACCTTSCCRPSSSVSLLCRPVCRPACC---VPVSSCCAPTSSRQPSYCRQA 265
Cdd:pfam05287  81 CVPSPCQRSCYSPRTSCvcspCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGfrpLGCLSKGFQSLGYGSSFCRPS 160

                         170
                  ....*....|....*...
gi 294862449  266 SCVSLLCRPVCSRPACYS 283
Cdd:pfam05287 161 YVSSRSYQPSCFRPSCGS 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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