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Conserved domains on  [gi|46397477|sp|P60891|]
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RecName: Full=Ribose-phosphate pyrophosphokinase 1; AltName: Full=PPRibP; AltName: Full=Phosphoribosyl pyrophosphate synthase I; Short=PRS-I

Protein Classification

ribose-phosphate diphosphokinase( domain architecture ID 11421473)

ribose-phosphate diphosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

CATH:  3.40.50.2020
EC:  2.7.6.1
Gene Ontology:  GO:0002189|GO:0000287|GO:0004749|GO:0005524|GO:0009156|GO:0016301|GO:0016310|GO:0006015|GO:0009165
PubMed:  11751055|7593598

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-314 7.24e-176

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


:

Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 488.80  E-value: 7.24e-176
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   1 MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462   1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENis 160
Cdd:COG0462  81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477 161 EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG 240
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46397477 241 ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKmKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-314 7.24e-176

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 488.80  E-value: 7.24e-176
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   1 MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462   1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENis 160
Cdd:COG0462  81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477 161 EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG 240
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46397477 241 ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKmKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
4-313 2.57e-165

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 461.89  E-value: 2.57e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    4 IKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEwr 163
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  164 NCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATR 243
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  244 VYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 4-314 5.38e-158

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 443.64  E-value: 5.38e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477     4 IKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIV-QSGCGEINDNLMELLIMINACKIASA 82
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEw 162
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   163 rNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGA 241
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46397477   242 TRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEdkmKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 4-120 3.81e-72

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 218.44  E-value: 3.81e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477     4 IKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 46397477    84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG 120
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 147-274 2.08e-24

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 95.93  E-value: 2.08e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477 147 AEPAVLKWIRENIseWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRM------VLVGDVKDRVAILVD 220
Cdd:cd06223   1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 46397477 221 DMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAisRINNACFEAVVVTNT 274
Cdd:cd06223  79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-314 7.24e-176

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 488.80  E-value: 7.24e-176
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   1 MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462   1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENis 160
Cdd:COG0462  81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477 161 EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG 240
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46397477 241 ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKmKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
4-313 2.57e-165

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 461.89  E-value: 2.57e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    4 IKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEwr 163
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  164 NCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATR 243
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  244 VYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 4-314 5.38e-158

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 443.64  E-value: 5.38e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477     4 IKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIV-QSGCGEINDNLMELLIMINACKIASA 82
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEw 162
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   163 rNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGA 241
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46397477   242 TRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEdkmKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 14-313 3.18e-115

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 334.74  E-value: 3.18e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   14 DLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFP 93
Cdd:PLN02369   2 ALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   94 YARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAG 173
Cdd:PLN02369  82 YARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  174 GAKRVTSIADRL-NVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGI 252
Cdd:PLN02369 162 GVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAV 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46397477  253 FSGPAISRINNACFEAVVVTNTIPQEDKmKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PLN02369 242 FSPPAIERLSSGLFQEVIVTNTIPVSEK-NYFPQLTVLSVANLLGETIWRVHDDCSVSSIF 301
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
3-313 3.76e-113

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 330.22  E-value: 3.76e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    3 NIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASA 82
Cdd:PRK02269   5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEW 162
Cdd:PRK02269  85 ESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLVG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  163 RNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERK--KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG 240
Cdd:PRK02269 165 DDVVVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAG 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397477  241 ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTI--PQEdkmKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK02269 245 ATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIylPEE---RLIDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
2-313 2.80e-112

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 328.04  E-value: 2.80e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    2 PNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIAS 81
Cdd:PRK04923   5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   82 ASRVTAVIPCFPYARQDKKDKS-RAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIrenis 160
Cdd:PRK04923  85 AASVTAVIPYFGYSRQDRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADI----- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  161 eWR-----NCTIVSPDAGGAKRVTSIADRL-NVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAD 234
Cdd:PRK04923 160 -WRaygtdNLIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAA 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46397477  235 KLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK04923 239 ALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 4-313 3.29e-112

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 328.24  E-value: 3.29e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    4 IKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:PRK02812  22 LRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASAR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIREniSEWR 163
Cdd:PRK02812 102 QITAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLAS--KNLE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  164 NCTIVSPDAGGAKRVTSIADRLN-VDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGAT 242
Cdd:PRK02812 180 DIVVVSPDVGGVARARAFAKKLNdAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAK 259

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46397477  243 RVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKmKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK02812 260 QVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPVPEE-RRFPQLKVLSVANMLGEAIWRIHEESSVSSMF 329
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
15-313 1.47e-111

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 325.75  E-value: 1.47e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   15 LSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPY 94
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   95 ARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEwRNCTIVSPDAGG 174
Cdd:PRK03092  81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVVSPDAGR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  175 AKRVTSIADRL-NVDFALIHKER--KKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHG 251
Cdd:PRK03092 160 VRVAEQWADRLgGAPLAFIHKTRdpTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHG 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46397477  252 IFSGPAISRINNACFEAVVVTNTIPQEDKmKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK03092 240 VLSGPAAERLKNCGAREVVVTDTLPIPEE-KRFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 1-313 4.70e-110

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 326.83  E-value: 4.70e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    1 MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA 80
Cdd:PTZ00145 117 MENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRA 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFD--IPVDNLYAEPAVLKWIREN 158
Cdd:PTZ00145 197 SAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTKK 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  159 isEWRNCTIVSPDAGGAKRVTSIADRLN------VDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHA 232
Cdd:PTZ00145 277 --DLYKPVIVSPDAGGVYRARKFQDGLNhrgisdCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEA 354

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  233 ADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYL 312
Cdd:PTZ00145 355 AKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDL 434


                 .
gi 46397477  313 F 313
Cdd:PTZ00145 435 F 435
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 2-317 7.09e-97

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 288.95  E-value: 7.09e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    2 PNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIAS 81
Cdd:PRK02458   8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   82 ASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISE 161
Cdd:PRK02458  88 ANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  162 WRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVlVGDVKDRVAILVDDMADTCGTICHAADKLLSAGA 241
Cdd:PRK02458 168 GSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGYI-IGDVAGKKAILIDDILNTGKTFAEAAKIVEREGA 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46397477  242 TRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDkmKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVP 317
Cdd:PRK02458 247 TEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKE--RVPKNVTYLSASELIADAIIRIHERKPLSPLFAYNK 320
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 6-314 8.99e-84

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 256.00  E-value: 8.99e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    6 IFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRV 85
Cdd:PRK00553  12 IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   86 TAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEwRNC 165
Cdd:PRK00553  92 TAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLELLGK-KDL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  166 TIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVY 245
Cdd:PRK00553 171 VVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVC 250

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46397477  246 AILTHGIFSGPAISRINNACFEAVV----VTNTIPQEdKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:PRK00553 251 VMATHGLFNKNAIQLFDEAFKKKLIdklfVSNSIPQT-KFEKKPQFKVVDLAHLYEEVLLCYANGGSISAIYT 322
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 4-120 3.81e-72

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 218.44  E-value: 3.81e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477     4 IKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 46397477    84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG 120
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 5-302 8.96e-67

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 210.92  E-value: 8.96e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    5 KIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEiNDNLMELLIMINACKIASASR 84
Cdd:PRK00934   1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   85 VTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGaDHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENIsewRN 164
Cdd:PRK00934  80 ITLVIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDKL---DD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  165 CTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRV 244
Cdd:PRK00934 156 PLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKV 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 46397477  245 YAILTHGIFSGPAISRINNACFEAVVVTNTIPqedkmkhcSKIQVIDISMILAEAIRR 302
Cdd:PRK00934 236 YVACVHPVLVGDAILKLYNAGVDEIIVTDTLE--------SEVSKISVAPLIADLLKK 285
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 161-313 2.66e-46

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 154.98  E-value: 2.66e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   161 EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKA--NEVDR----------------------------MVLVGD 210
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAesDEVDGrqspppyrsrtvsrslglpeiipkekppMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   211 VKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVI 290
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|...
gi 46397477   291 DISMILAEAIRRTHNGESVSYLF 313
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLF 183
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
13-302 4.15e-46

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 157.79  E-value: 4.15e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   13 QDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSgCGEINDNLMELLIMINACKIASASRVTAVIPCF 92
Cdd:PRK07199  12 EAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCS-LDRPDEKLLPLLFAAEAARELGARRVGLVAPYL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   93 PYARQDKKDKSRAPISAKLVANMLSvAGADHIITMD--LH-ASQIQGFFDIPVDNLYAEPAVLKWIRENISEWrncTIVS 169
Cdd:PRK07199  91 AYMRQDIAFHPGEAISQRHFARLLS-GSFDRLVTVDphLHrYPSLSEVYPIPAVVLSAAPAIAAWIRAHVPRP---LLIG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  170 PDAGGAKRVTSIADRLNVDFALIHKERKKANEVDrmVLVGDV---KDRVAILVDDMADTCGTICHAADKLLSAGATRVYA 246
Cdd:PRK07199 167 PDEESEQWVAAVAERAGAPHAVLRKTRHGDRDVE--ISLPDAapwAGRTPVLVDDIVSTGRTLIEAARQLRAAGAASPDC 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 46397477  247 ILTHGIFSGPAISRINNACFEAVVVTNTIPqedkmkHCSkiQVIDISMILAEAIRR 302
Cdd:PRK07199 245 VVVHALFAGDAYSALAAAGIARVVSTDTVP------HPS--NAISLAPLLAEALRR 292
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 29-312 2.08e-40

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 145.09  E-value: 2.08e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   29 KVVTKKFSNQETCVEIGESVRGEDVYIVQ---------SGCGE-----INDNLMELLIMINACKiASASRVTAVIPCFPY 94
Cdd:PRK06827  56 PAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   95 ARQDKKdKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI-PVDNLYAEPAVLKWIRENISEWR----NCTIVS 169
Cdd:PRK06827 135 SRQHKR-KGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLmGFENLYPSYQIIKALLKNEKDLEidkdHLMVIS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  170 PDAGGAKRVTSIADRLNVDFALIHKERK-------KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGAT 242
Cdd:PRK06827 214 PDTGAMDRAKYYASVLGVDLGLFYKRRDysrvvngRNPIVAHEFLGRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAK 293

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46397477  243 RVYAILTHGIFSGpAISRINNA----CFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYL 312
Cdd:PRK06827 294 KIIVAATFGFFTN-GLEKFDKAyeegYFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKL 366
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 147-274 2.08e-24

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 95.93  E-value: 2.08e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477 147 AEPAVLKWIRENIseWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRM------VLVGDVKDRVAILVD 220
Cdd:cd06223   1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 46397477 221 DMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAisRINNACFEAVVVTNT 274
Cdd:cd06223  79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 3-277 2.26e-10

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 60.47  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477    3 NIKIFSGSSHQDLSQKIADRLG-LELGKVVTKKFSNQETCVEIG--ESVRGEDVYIVQSGcgEINDNLMELLIMINACKI 79
Cdd:PLN02297  16 QVHLFYCEETEELARKIAAESDaIELGSINWRKFPDGFPNLFINnaHGIRGQHVAFLASF--SSPAVIFEQLSVIYALPK 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   80 ASASRVTAVIPCFP---YAR-QDKKDKSRAPISAKLVANM-LSVAGADHIITMDLHASQIQGFFDIPVDNLYAE--PAVL 152
Cdd:PLN02297  94 LFVASFTLVLPFFPtgtSERvEREGDVATAFTLARILSNIpISRGGPTSLVIFDIHALQERFYFGDNVLPCFESgiPLLK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477  153 KWIREnISEWRNCTIVSPDAGGAKRVTSIADrlnvDFALI--HKERkkanEVD-RMVLV--GDVKDRVAILVDDMADTCG 227
Cdd:PLN02297 174 KRLQQ-LPDSDNIVIAFPDDGAWKRFHKQFE----HFPMVvcTKVR----EGDkRIVRIkeGNPAGRHVVIVDDLVQSGG 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 46397477  228 TICHAADKLLSAGATRVYAILTHGIFSGPAISRINN------ACFEAVVVTNTIPQ 277
Cdd:PLN02297 245 TLIECQKVLAAHGAAKVSAYVTHGVFPNESWERFTHdnggpeAGFAYFWITDSCPQ 300
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 141-244 4.94e-10

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 56.99  E-value: 4.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397477   141 PVDNLYAEPAVLKWIRENISE------WRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKAN---EVDRMVLVGDV 211
Cdd:pfam00156   1 SVDEILDNPAILKAVARLAAQinedygGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDtseVMKTSSALPDL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 46397477   212 KDRVAILVDDMADTCGTICHAADKLLSAGATRV 244
Cdd:pfam00156  81 KGKTVLIVDDILDTGGTLLKVLELLKNVGPKEV 113
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 207-247 2.68e-03

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 38.53  E-value: 2.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 46397477  207 LVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAI 247
Cdd:PRK00129 118 LPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVL 158
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 178-251 5.26e-03

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 37.44  E-value: 5.26e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46397477 178 VTSIADRLNVDFALIhkeRKKANEVDRM-VLVGDVK--DRVAIlVDDMADTCGTICHAADKLLSAGAT--RVYAILTHG 251
Cdd:COG0461  78 AAAVARALGLPAIFV---RKEAKDHGTGgQIEGGLLpgERVLV-VEDVITTGGSVLEAVEALREAGAEvvGVAVIVDRE 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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