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Conserved domains on  [gi|1238944359|gb|PAP35627|]
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formate dehydrogenase subunit beta [Salmonella enterica subsp. enterica serovar Hadar]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FDH-beta super family cl36936
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 7-289 4.91e-163

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


The actual alignment was detected with superfamily member TIGR01582:

Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 454.75  E-value: 4.91e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359   7 DIIRRSATNGftPAPQARDHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVGN-NVGVYDNPADLTAKSWTVMRFSEV 85
Cdd:TIGR01582   1 DIKRLSATKE--PDPSVKTYPTELAKLIDVSSCIGCKACQAACQEWNDTTPPILSrKVGGYQNPPDLLPETFTLMRFKEG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  86 EQNDKLEWLIRKDGCMHCADPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVD 165
Cdd:TIGR01582  79 EESDGLEWLIRKDGCMHCREPGCLKACPAPGAIIQYQNGIVDFDHSKCIGCGYCIVGCPFNIPRYDKVDNRPYKCTLCID 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 166 RVTVGQEPACVKTCPTGAIHFGSKEDMKTLASERVAELKTRGYDNAGLYDPAGVGGTHVMYVLHHADKPNLYHGLPENPE 245
Cdd:TIGR01582 159 RVSVGQEPACVKTCPTNAISFGFKEDMKERAEKRVADLKSRGYPNAGLYDPPGVGGTHVMYVLHHGDKPKDYQDLPEDPR 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1238944359 246 ISETVKFWKGVWKPLAAFGFAATFAASVFHYVGVGPNRAEEEDD 289
Cdd:TIGR01582 239 IDASVGLWKGVLKTIGSIAMGGTALGVFLHLILWGPNKVLGGKE 282
 
Name Accession Description Interval E-value
FDH-beta TIGR01582
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 7-289 4.91e-163

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 454.75  E-value: 4.91e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359   7 DIIRRSATNGftPAPQARDHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVGN-NVGVYDNPADLTAKSWTVMRFSEV 85
Cdd:TIGR01582   1 DIKRLSATKE--PDPSVKTYPTELAKLIDVSSCIGCKACQAACQEWNDTTPPILSrKVGGYQNPPDLLPETFTLMRFKEG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  86 EQNDKLEWLIRKDGCMHCADPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVD 165
Cdd:TIGR01582  79 EESDGLEWLIRKDGCMHCREPGCLKACPAPGAIIQYQNGIVDFDHSKCIGCGYCIVGCPFNIPRYDKVDNRPYKCTLCID 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 166 RVTVGQEPACVKTCPTGAIHFGSKEDMKTLASERVAELKTRGYDNAGLYDPAGVGGTHVMYVLHHADKPNLYHGLPENPE 245
Cdd:TIGR01582 159 RVSVGQEPACVKTCPTNAISFGFKEDMKERAEKRVADLKSRGYPNAGLYDPPGVGGTHVMYVLHHGDKPKDYQDLPEDPR 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1238944359 246 ISETVKFWKGVWKPLAAFGFAATFAASVFHYVGVGPNRAEEEDD 289
Cdd:TIGR01582 239 IDASVGLWKGVLKTIGSIAMGGTALGVFLHLILWGPNKVLGGKE 282
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 31-238 6.39e-151

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 421.03  E-value: 6.39e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  31 AKLIDVTTCIGCKACQVACSEWNDIRDEVGNNVGVYDNPADLTAKSWTVMRFSEVEQNDKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd10558     1 AKLIDVSKCIGCKACQVACKEWNDLRAEVGHNVGTYQNPADLSPETWTLMKFREVEDNGKLEWLIRKDGCMHCADPGCLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 111 ACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFGSKE 190
Cdd:cd10558    81 ACPSPGAIVQYANGIVDFQSDKCIGCGYCIKGCPFDIPRISKDDNKMYKCTLCSDRVSVGLEPACVKTCPTGALHFGTKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1238944359 191 DMKTLASERVAELKTRGYDNAGLYDPAGVGGTHVMYVLHHADKPNLYH 238
Cdd:cd10558   161 DMLALAEKRVAALKERGYTNAGLYDPKGVGGTHVMYVLHHADKPEGYP 208
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 25-227 9.66e-72

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 219.43  E-value: 9.66e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  25 DHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVgnnvgvydnpadltakSWTVMRFSEVEQNDKLEWLIRKDGCMHCA 104
Cdd:COG0437     1 LSMKRYGMVIDLTKCIGCRACVVACKEENNLPVGV----------------TWRRVRRYEEGEFPNVEWLFVPVLCNHCD 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 105 DPGCLKACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAI 184
Cdd:COG0437    65 DPPCVKVCPT-GATYKREDGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVEKCTFCADRLDEGLLPACVEACPTGAL 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1238944359 185 HFGSKEDMKTLASERVAELKTRgydnaGLYDPAGvGGTHVMYV 227
Cdd:COG0437   144 VFGDLDDPESEVSKRLAELPAY-----RLLPELG-TKPSVYYL 180
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
13-247 1.13e-45

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 157.14  E-value: 1.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  13 ATNGFTPAPQARDHQ------EEVAKLIDVTTCIGCKACQVACSEWNDIRDEVGNNvGVYDNPADLTAKSWTVM---RFS 83
Cdd:PRK10882   15 LLAGALPSVSHAAAEnrppipGALGMLYDSTLCVGCQACVTKCQEINFPERNPQGE-QTWDNPDKLSPYTNNIIkvwKSG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  84 EVEQNDKLE--WLIRKDGCMHCADPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPED--NRVYK 159
Cdd:PRK10882   94 TGVNKDQEEngYAYIKKQCMHCVDPNCVSVCPVSALTKDPKTGIVHYDKDVCTGCRYCMVACPFNVPKYDYNNpfGAIHK 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 160 CTLC----VDRVTVGQEPACVKTCPTGAIHFGSKEDMKTLASERVAE-------------------LKTRGYDNAGLYDP 216
Cdd:PRK10882  174 CELCnqkgVERLDKGGLPGCVEVCPTGAVIFGTREELLAEAKRRLALkpgseyhyprqtlksgdtyLHTVPKYYPHVYGE 253

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1238944359 217 AGVGGTHVMYvLHHADKPNLyhGLPENPEIS 247
Cdd:PRK10882  254 KEGGGTQVLV-LSGVPFENL--GLPKLDDLS 281
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 91-187 2.35e-29

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 107.33  E-value: 2.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  91 LEWLIRKDGCMHCADPGCLKACPAeGAIIQ-YANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTV 169
Cdd:pfam13247   1 VDWLFFPEQCRHCLNPPCKASCPV-GAIYKdEETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAEKCDMCYDRVEA 79

                          90
                  ....*....|....*...
gi 1238944359 170 GQEPACVKTCPTGAIHFG 187
Cdd:pfam13247  80 GLLPACVQTCPTGAMNFG 97
FDH3_beta NF038355
formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the ...
 33-208 1.29e-21

formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the FDH3 type of formate dehydrogenase as found in Methylorubrum (Methylobacterium) extorquens.


Pssm-ID: 439648 [Multi-domain]  Cd Length: 180  Bit Score: 89.74  E-value: 1.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIrdevgnnvgvydnpadltakSWTVMRFSEVEQNDKLEWLIRKD-GCMHCADPGCLKA 111
Cdd:NF038355    6 LCDTERCIECNGCVVACKNAHEL--------------------PWGINRRRVVTLNDGVPGEKSISvACMHCTDAPCAAV 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 112 CPAEgAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLnPEDN------RVYKCTLC-----------------VDRVT 168
Cdd:NF038355   66 CPVD-CFYIRADGIVLHDKDKCIGCGYCLYACPFGAPQF-PKDGafgargKMDKCTFCaggpeetnseaerekygQNRIA 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1238944359 169 VGQEPACVKTCPTGAIHFGSKEDMKTLASERVAelkTRGY 208
Cdd:NF038355  144 EGKLPLCAEMCSTKALLAGDAEVVADIYRERVV---ARGA 180
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 130-189 3.92e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 47.16  E-value: 3.92e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238944359 130 SEQCIGCGYCIAGCPFNVPRLnpEDNRVY---KCTLCVdrvtvgqepACVKTCPTGAIHFGSK 189
Cdd:NF038196  184 TDKCIGCGICAKVCPVNNIEM--EDGKPVwghNCTHCL---------ACIHRCPKEAIEYGKK 235
 
Name Accession Description Interval E-value
FDH-beta TIGR01582
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 7-289 4.91e-163

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 454.75  E-value: 4.91e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359   7 DIIRRSATNGftPAPQARDHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVGN-NVGVYDNPADLTAKSWTVMRFSEV 85
Cdd:TIGR01582   1 DIKRLSATKE--PDPSVKTYPTELAKLIDVSSCIGCKACQAACQEWNDTTPPILSrKVGGYQNPPDLLPETFTLMRFKEG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  86 EQNDKLEWLIRKDGCMHCADPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVD 165
Cdd:TIGR01582  79 EESDGLEWLIRKDGCMHCREPGCLKACPAPGAIIQYQNGIVDFDHSKCIGCGYCIVGCPFNIPRYDKVDNRPYKCTLCID 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 166 RVTVGQEPACVKTCPTGAIHFGSKEDMKTLASERVAELKTRGYDNAGLYDPAGVGGTHVMYVLHHADKPNLYHGLPENPE 245
Cdd:TIGR01582 159 RVSVGQEPACVKTCPTNAISFGFKEDMKERAEKRVADLKSRGYPNAGLYDPPGVGGTHVMYVLHHGDKPKDYQDLPEDPR 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1238944359 246 ISETVKFWKGVWKPLAAFGFAATFAASVFHYVGVGPNRAEEEDD 289
Cdd:TIGR01582 239 IDASVGLWKGVLKTIGSIAMGGTALGVFLHLILWGPNKVLGGKE 282
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 31-238 6.39e-151

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 421.03  E-value: 6.39e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  31 AKLIDVTTCIGCKACQVACSEWNDIRDEVGNNVGVYDNPADLTAKSWTVMRFSEVEQNDKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd10558     1 AKLIDVSKCIGCKACQVACKEWNDLRAEVGHNVGTYQNPADLSPETWTLMKFREVEDNGKLEWLIRKDGCMHCADPGCLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 111 ACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFGSKE 190
Cdd:cd10558    81 ACPSPGAIVQYANGIVDFQSDKCIGCGYCIKGCPFDIPRISKDDNKMYKCTLCSDRVSVGLEPACVKTCPTGALHFGTKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1238944359 191 DMKTLASERVAELKTRGYDNAGLYDPAGVGGTHVMYVLHHADKPNLYH 238
Cdd:cd10558   161 DMLALAEKRVAALKERGYTNAGLYDPKGVGGTHVMYVLHHADKPEGYP 208
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 32-187 2.14e-86

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 255.40  E-value: 2.14e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  32 KLIDVTTCIGCKACQVACSEWNDIRDEVGNNVGVYDNPADLTAKSWTVMRFSEVEQND-KLEWLIRKDGCMHCADPGCLK 110
Cdd:cd16366     1 FLVDTSRCTGCRACQVACKQWNGLPAEKTEFTGSYQNPPDLTAHTWTLVRFYEVEKPGgDLSWLFRKDQCMHCTDAGCLA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238944359 111 ACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFG 187
Cdd:cd16366    81 ACPT-GAIIRTETGTVVVDPETCIGCGYCVNACPFDIPRFDEETGRVAKCTLCYDRISNGLQPACVKTCPTGALTFG 156
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 33-245 6.40e-81

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 244.22  E-value: 6.40e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIR-DEVGNNVGVYDNPADLTAKSWTVMRFSEVEQNDK-------LEWLIRKDGCMHCA 104
Cdd:cd10560     3 FTDTSICIGCKACEVACKQWNQLPaDGYDFSGMSYDNTGDLSASTWRHVKFIERPTEDGpaneggdLQWLFMSDVCKHCT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 105 DPGCLKACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAI 184
Cdd:cd10560    83 DAGCLEACPT-GAIFRTEFGTVYIQPDICNGCGYCVAACPFGVIDRNEETGRAHKCTLCYDRLKDGLEPACAKACPTGSI 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1238944359 185 HFGSKEDMKTLASERVAELKTRGYDNAGLY--DP-AGVGGTHVMYVLhhADKPNLYhGLPENPE 245
Cdd:cd10560   162 QFGPLEELRERARARVEQLHEQGVVEAYLYgaDPtEGYGGLNAFFLL--LDKPEVY-GLPADPL 222
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 32-192 1.35e-75

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 228.34  E-value: 1.35e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  32 KLIDVTTCIGCKACQVACSEWNDIRDEVGNNVGVYDNPADLTAKSWTVMRFSEVE-QNDKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd10562     1 MLVDTSKCTACRGCQVACKQWNQLPAEKTPFTGSYQNPPDLTPNTWTLIRFYEHEeDNGGIRWLFRKRQCMHCTDAACVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 111 ACPaEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFGSKE 190
Cdd:cd10562    81 VCP-TGALYKTENGAVVVDEDKCIGCGYCVAACPFDVPRYDETTNKITKCTLCFDRIENGMQPACVKTCPTGALTFGDRD 159


                  ..
gi 1238944359 191 DM 192
Cdd:cd10562   160 EL 161
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 25-227 9.66e-72

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 219.43  E-value: 9.66e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  25 DHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVgnnvgvydnpadltakSWTVMRFSEVEQNDKLEWLIRKDGCMHCA 104
Cdd:COG0437     1 LSMKRYGMVIDLTKCIGCRACVVACKEENNLPVGV----------------TWRRVRRYEEGEFPNVEWLFVPVLCNHCD 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 105 DPGCLKACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAI 184
Cdd:COG0437    65 DPPCVKVCPT-GATYKREDGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVEKCTFCADRLDEGLLPACVEACPTGAL 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1238944359 185 HFGSKEDMKTLASERVAELKTRgydnaGLYDPAGvGGTHVMYV 227
Cdd:COG0437   144 VFGDLDDPESEVSKRLAELPAY-----RLLPELG-TKPSVYYL 180
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 31-226 8.83e-67

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 207.06  E-value: 8.83e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  31 AKLIDVTTCIGCKACQVACSEWNDIRDEVGNNVGVYDNPADLTAKSWTVMRFSEVEqNDKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd10561     1 GVLYDTTRCIGCRACEVACKEWNGLPAEDTAFGPGWDNPRDLSAKTYTVIKRYEVE-TGGKGFVFVKRQCMHCLDPACVS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 111 ACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPR-----LNPednRVYKCTLCVDRVTVGQEPACVKTCPTGAIH 185
Cdd:cd10561    80 ACPV-GALRKTPEGPVTYDEDKCIGCRYCMVACPFNIPKyewdsANP---KIRKCTMCYDRLKEGKQPACVEACPTGALL 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1238944359 186 FGSKEDMKTLASERVAELKTRGYDNA-GLYDpagVGGTHVMY 226
Cdd:cd10561   156 FGKREELLAEAKRRIAANPGRYVDHVyGEKE---AGGTSVLY 194
W-FDH cd10559
tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit ...
 33-230 8.78e-64

tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319881 [Multi-domain]  Cd Length: 200  Bit Score: 199.58  E-value: 8.78e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIRDEVGNNVGVYDNPADLTAKSWTVMRFSEVE-QNDKLEWLIRKDGCMHCADPGCLKA 111
Cdd:cd10559     3 LIDTTRCTACRGCQVACKQWNQLPAEQTKNTGSHQNPPDLSANTYKLVRFNEVRnENGKPDWLFFPDQCRHCVTPPCKDA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 112 CP-AEGAIIQ-YANGIVDFQSEQCIGC-GYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFGS 188
Cdd:cd10559    83 ADmVPGAVIQdEATGAVVFTEKTAELDfDDVLSACPYNIPRKNEATGRIVKCDMCIDRVSNGLQPACVKACPTGAMNFGD 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1238944359 189 KEDMKTLASERVAELKTRgYDNAGLYDPAGVggtHVMYVLHH 230
Cdd:cd10559   163 RDEMLAMASKRLEELKKR-YPKANLYDPDDV---RVIWLLAE 200
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 33-187 1.43e-49

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 161.02  E-value: 1.43e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIRdevgnnvgvydnpadlTAKSWTVMRFSEVEqndKLEWLIRKDGCMHCADPGCLKAC 112
Cdd:cd04410     2 VVDLDRCIGCGTCEVACKQEHGLR----------------PGPDWSRIKVIEGG---GLERAFLPVSCMHCEDPPCVKAC 62

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1238944359 113 PaEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFG 187
Cdd:cd04410    63 P-TGAIYKDEDGIVLIDEDKCIGCGSCVEACPYGAIVFDPEPGKAVKCDLCGDRLDEGLEPACVKACPTGALTFG 136
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 33-187 1.21e-48

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 158.49  E-value: 1.21e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIRDEVgnnvgvydnpadltakswtvmRFSEVEQNDKLEWLIRKD-----GCMHCADPG 107
Cdd:cd16371     3 YFDQERCIGCKACEIACKDKNDLPPGV---------------------NWRRVYEYEGGEFPEVFAyflsmSCNHCENPA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 108 CLKACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFG 187
Cdd:cd16371    62 CVKVCPT-GAITKREDGIVVVDQDKCIGCGYCVWACPYGAPQYNPETGKMDKCDMCVDRLDEGEKPACVAACPTRALDFG 140
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 33-206 2.87e-46

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 154.23  E-value: 2.87e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIRDEVGNNvgvydnpadltaksWTVMRFSEVEQNDKLEWLIRkdGCMHCADPGCLKAC 112
Cdd:cd10551     2 VIDLRKCIGCGACVVACKAENNVPPGVFRN--------------RVLEYEVGEYPNVKRTFLPV--LCNHCENPPCVKVC 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 113 PAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVY------------KCTLCVDRVTVGQEPACVKTCP 180
Cdd:cd10551    66 PT-GATYKREDGIVLVDYDKCIGCRYCMAACPYGARYFNPEEPHEFgevpvrpkgvveKCTFCYHRLDEGLLPACVEACP 144

                         170       180
                  ....*....|....*....|....*.
gi 1238944359 181 TGAIHFGSKEDMKTLASERVAELKTR 206
Cdd:cd10551   145 TGARIFGDLDDPNSEVSKLLAERRAY 170
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
13-247 1.13e-45

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 157.14  E-value: 1.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  13 ATNGFTPAPQARDHQ------EEVAKLIDVTTCIGCKACQVACSEWNDIRDEVGNNvGVYDNPADLTAKSWTVM---RFS 83
Cdd:PRK10882   15 LLAGALPSVSHAAAEnrppipGALGMLYDSTLCVGCQACVTKCQEINFPERNPQGE-QTWDNPDKLSPYTNNIIkvwKSG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  84 EVEQNDKLE--WLIRKDGCMHCADPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPED--NRVYK 159
Cdd:PRK10882   94 TGVNKDQEEngYAYIKKQCMHCVDPNCVSVCPVSALTKDPKTGIVHYDKDVCTGCRYCMVACPFNVPKYDYNNpfGAIHK 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 160 CTLC----VDRVTVGQEPACVKTCPTGAIHFGSKEDMKTLASERVAE-------------------LKTRGYDNAGLYDP 216
Cdd:PRK10882  174 CELCnqkgVERLDKGGLPGCVEVCPTGAVIFGTREELLAEAKRRLALkpgseyhyprqtlksgdtyLHTVPKYYPHVYGE 253

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1238944359 217 AGVGGTHVMYvLHHADKPNLyhGLPENPEIS 247
Cdd:PRK10882  254 KEGGGTQVLV-LSGVPFENL--GLPKLDDLS 281
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 34-192 3.54e-36

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 127.50  E-value: 3.54e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  34 IDVTTCIGCKACQVACSEWNDIRDEVGNNVGvYDNPADLTAKSWTVmrfseveqndklewlirkdgCMHCADPGCLKACP 113
Cdd:cd16369     6 IDPSRCIGCRACVAACRECGTHRGKSMIHVD-YIDRGESTQTAPTV--------------------CMHCEDPTCAEVCP 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 114 AEgAIIQYANGIV-DFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFGSKEDM 192
Cdd:cd16369    65 AD-AIKVTEDGVVqSALKPRCIGCSNCVNACPFGVPKYDEERNLMMKCDMCYDRTSVGKAPMCASVCPSGALFYGTREEI 143
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 33-191 5.79e-34

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 120.84  E-value: 5.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIRdevgNNVGVYDNPaDLTAKSWTvmrfseveqndklewlirkdgCMHCADPGCLKAC 112
Cdd:cd16374     2 YVDPERCIGCRACEIACAREHSGK----PRISVEVVE-DLASVPVR---------------------CRHCEDAPCMEVC 55

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1238944359 113 PaEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFGSKED 191
Cdd:cd16374    56 P-TGAIYRDEDGAVLVDPDKCIGCGMCAMACPFGVPRFDPSLKVAVKCDLCIDRRREGKLPACVEACPTGALKFGDIEE 133
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 35-188 1.63e-32

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 117.08  E-value: 1.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  35 DVTTCIGCKACQVACSEWNdirdevgnNVGVYDNPADLTAKSwtvmrFSEVEQNDKLEWLIRKdgCMHCADPGCLKACPA 114
Cdd:cd10553     8 DSKRCIGCLACEVHCKVKN--------NLPVGPRLCRIFAVG-----PKMVGGKPRLKFVYMS--CFHCENPWCVKACPT 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1238944359 115 eGAIIQY-ANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCPTGAIHFGS 188
Cdd:cd10553    73 -GAMQKReKDGIVYVDQELCIGCKACIEACPWGIPQWNPATGKVVKCDYCMDRIDQGLKPACVTGCTTHALSFVR 146
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 91-187 2.35e-29

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 107.33  E-value: 2.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  91 LEWLIRKDGCMHCADPGCLKACPAeGAIIQ-YANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTV 169
Cdd:pfam13247   1 VDWLFFPEQCRHCLNPPCKASCPV-GAIYKdEETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAEKCDMCYDRVEA 79

                          90
                  ....*....|....*...
gi 1238944359 170 GQEPACVKTCPTGAIHFG 187
Cdd:pfam13247  80 GLLPACVQTCPTGAMNFG 97
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 33-186 7.17e-29

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 107.28  E-value: 7.17e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDirdevgnnvGVYdNPAdltaKS-WTVMRFSEVEqndklewLIRKDGCMHCADPGCLKA 111
Cdd:cd10550     2 VVDPEKCTGCRTCELACSLKHE---------GVF-NPS----LSrIRVVRFEPEG-------LDVPVVCRQCEDAPCVEA 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238944359 112 CPaEGAIIQ-YANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCvdrvtvGQEPACVKTCPTGAIHF 186
Cdd:cd10550    61 CP-VGAISRdEETGAVVVDEDKCIGCGMCVEACPFGAIRVDPETGKAIKCDLC------GGDPACVKVCPTGALEF 129
DMSOR_beta_like cd16368
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 30-196 8.92e-29

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319890 [Multi-domain]  Cd Length: 200  Bit Score: 109.05  E-value: 8.92e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  30 VAKLIDVTTCIGCK-----ACQVACSEWNDIR--DEVGNNVGVY-------------DNPADLTAKSWTVMRFSEVEQND 89
Cdd:cd16368     1 LATLIDLTKCDGCPgesipACVRACREKNQARfpEPVSKPIQPYwprkriedwsdkrDVTDRLTPYNWLYVQKLTVDTAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  90 KLEWLIRKDGCMHCADPGCLKACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPR----------LNPE---DNR 156
Cdd:cd16368    81 GEKEVFIPRRCMHCDNPPCAKLCPF-GAARKTPEGAVYIDDDLCFGGAKCRDVCPWHIPQrqagvgiylhLAPEyagGGV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1238944359 157 VYKCTLCVDRVTVGQEPACVKTCPTGAIHFGSKEDMKTLA 196
Cdd:cd16368   160 MYKCDLCKDLLAQGKPPACIEACPKGAQYFGPRKEMVALA 199
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 33-187 5.44e-28

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 105.42  E-value: 5.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDirdevgnnvgVYDNPADLTAKSWTVMRFSEVEQNDKLEWLIRkdgCMHCADPGCLKAC 112
Cdd:cd10563     3 FIDEEKCLGCKLCEVACAVAHS----------KSKDLIKAKLEKERPRPRIRVEESGGRSFPLQ---CRHCDEPPCVKAC 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238944359 113 PAeGAIIQY-ANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRvtvgQEPACVKTCPTGAIHFG 187
Cdd:cd10563    70 MS-GAMHKDpETGIVIHDEEKCVGCWMCVMVCPYGAIRPDKERKVALKCDLCPDR----ETPACVEACPTGALVLE 140
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
13-204 1.51e-26

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 104.57  E-value: 1.51e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  13 ATNGFTPAPQARDHQEEVAKLIDVTTCIGCKACQVACSEWNDI-RDEVGNNVGVYDnpadltakswTVMRFSEVEQNDKL 91
Cdd:PRK14993   27 AKFPFSPERHEGSPRHRYAMLIDLRRCIGCQSCTVSCTIENQTpQGAFRTTVNQYQ----------VQREGSQEVTNVLL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  92 EWLirkdgCMHCADPGCLKACPAEgAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQ 171
Cdd:PRK14993   97 PRL-----CNHCDNPPCVPVCPVQ-ATFQREDGIVVVDNKRCVGCAYCVQACPYDARFINHETQTADKCTFCVHRLEAGL 170

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1238944359 172 EPACVKTCPTGAIHFGSKED----MKTLASERVAELK 204
Cdd:PRK14993  171 LPACVESCVGGARIIGDIKDphsrIATMLHQHRDAIK 207
TH_beta_N cd10552
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ...
 33-205 1.27e-25

N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2.


Pssm-ID: 319874 [Multi-domain]  Cd Length: 186  Bit Score: 100.48  E-value: 1.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACsewndiRDE-VGNNVGVYDNPADLTAKSWtvMRFSEVEQND--KLEWLIRKDGCMHCADPGCL 109
Cdd:cd10552     2 VIDVAKCNGCYNCFLAC------KDEhVGNDWPGYAAPQPRHGHFW--MRILRRERGQypKVDVAYLPVPCNHCDNAPCI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 110 KACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVG-QEPACVKTCPTGAIHFGS 188
Cdd:cd10552    74 KAAKD-GAVYKRDDGIVIIDPEKAKGQKQLVDACPYGAIYWNEELQVPQKCTFCAHLLDDGwKEPRCVQACPTGALRFGK 152

                         170
                  ....*....|....*..
gi 1238944359 189 KEDMKTLASERVAELKT 205
Cdd:cd10552   153 LEDEEMAAKAAEEGLEV 169
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
33-186 4.60e-23

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 92.03  E-value: 4.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEwndirdevgnnvgVYDNPADLTAKSW-TVMRFSEVeqndklewlIRKDGCMHCADPGCLKA 111
Cdd:COG1142     6 IADPEKCIGCRTCEAACAV-------------AHEGEEGEPFLPRiRVVRKAGV---------SAPVQCRHCEDAPCAEV 63

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238944359 112 CPAeGAIIQyANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNR--VYKCTLCVDRvtvGQEPACVKTCPTGAIHF 186
Cdd:COG1142    64 CPV-GAITR-DDGAVVVDEEKCIGCGLCVLACPFGAITMVGEKSRavAVKCDLCGGR---EGGPACVEACPTGALRL 135
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 39-186 8.24e-23

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 91.94  E-value: 8.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  39 CIGCKACQVACSEWNdirdEVGNNVGVYDNPADLTAKSWtvmrfseveqndklewLIRKDG------CMHCADPGCLKAC 112
Cdd:cd10554     9 CIGCRTCEVACAAAH----SGKGIFEAGTDGLPFLPRLR----------------VVKTGEvtapvqCRQCEDAPCANVC 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 113 PAeGAIIQyANGIVDFQSEQCIGCGYCIAGCPF-----------NVPRLNPEDNRVYKCTLCVDRvtvGQEPACVKTCPT 181
Cdd:cd10554    69 PV-GAISQ-EDGVVQVDEERCIGCKLCVLACPFgaiemapttvpGVDWERGPRAVAVKCDLCAGR---EGGPACVEACPT 143


                  ....*
gi 1238944359 182 GAIHF 186
Cdd:cd10554   144 KALTL 148
FDH3_beta NF038355
formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the ...
 33-208 1.29e-21

formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the FDH3 type of formate dehydrogenase as found in Methylorubrum (Methylobacterium) extorquens.


Pssm-ID: 439648 [Multi-domain]  Cd Length: 180  Bit Score: 89.74  E-value: 1.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIrdevgnnvgvydnpadltakSWTVMRFSEVEQNDKLEWLIRKD-GCMHCADPGCLKA 111
Cdd:NF038355    6 LCDTERCIECNGCVVACKNAHEL--------------------PWGINRRRVVTLNDGVPGEKSISvACMHCTDAPCAAV 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 112 CPAEgAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLnPEDN------RVYKCTLC-----------------VDRVT 168
Cdd:NF038355   66 CPVD-CFYIRADGIVLHDKDKCIGCGYCLYACPFGAPQF-PKDGafgargKMDKCTFCaggpeetnseaerekygQNRIA 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1238944359 169 VGQEPACVKTCPTGAIHFGSKEDMKTLASERVAelkTRGY 208
Cdd:NF038355  144 EGKLPLCAEMCSTKALLAGDAEVVADIYRERVV---ARGA 180
NarH_like cd16365
beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several ...
 29-194 5.30e-20

beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several DMSO reductase superfamily, including nitrate reductase A, ethylbenzene dehydrogenase and selenate reductase. DMSO Reductase (DMSOR) family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. . The beta subunits of DMSOR contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Nitrate reductase A contains three subunits (the catalytic subunit NarG, the catalytic subunit NarH with four [Fe-S] clusters, and integral membrane subunit NarI) and often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Ethylbenzene dehydrogenase oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. Selenate reductase catalyzes reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor.


Pssm-ID: 319887 [Multi-domain]  Cd Length: 201  Bit Score: 85.71  E-value: 5.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  29 EVAKLIDVTTCIGCKACQVACSEWNDIRDEVG----NNVGVYdnPADLTAKSWtvmrfsEVEQNDKLEWL----IRKDGC 100
Cdd:cd16365     2 QFAAVFNLNKCIGCQTCTVACKNAWTYRKGQEymwwNNVETK--PGGGYPQDW------EVKTIDNGGNTrfffYLQRLC 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 101 MHCADPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTCP 180
Cdd:cd16365    74 NHCTNPACLAACPRGAIYKREEDGIVLIDQKRCRGYRKCVEQCPYKKIYFNGLSRVSEKCIACYPRIEGGDPTRCMSACV 153

                         170
                  ....*....|....
gi 1238944359 181 TGAIHFGSKEDMKT 194
Cdd:cd16365   154 GRIRLQGFLDDNPK 167
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 39-199 4.18e-19

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 87.49  E-value: 4.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  39 CIGCKACQVACSewndirdeVGNNVGVY-DNPADLTAKswtVMRFSEVEQNDKLEwlirkdgCMHCADPGCLKACPaEGA 117
Cdd:PRK12769   12 CLGCHACEIACV--------MAHNDEQHvLSQHHFHPR---ITVIKHQQQRSAVT-------CHHCEDAPCARSCP-NGA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 118 IIQYANGIVDFQsEQCIGCGYCIAGCPFNVPR--LNPEDN-----RVYKCTLCVDRvtvGQEPACVKTCPTGAIHFGSKE 190
Cdd:PRK12769   73 ISHVDDSIQVNQ-QKCIGCKSCVVACPFGTMQivLTPVAAgkvkaTAHKCDLCAGR---ENGPACVENCPADALQLVTEQ 148


                  ....*....
gi 1238944359 191 DMKTLASER 199
Cdd:PRK12769  149 ALSGMAKSR 157
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
 100-191 7.03e-19

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 85.05  E-value: 7.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 100 CMHCADPGCLKACPaEGAIIQYA-NGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKT 178
Cdd:cd10555   133 CNHCTNPACLAACP-RKAIYKREeDGIVLVDQDRCRGYRYCVEACPYKKIYFNPVEQKSEKCIFCYPRIEKGVAPACARQ 211

                          90
                  ....*....|...
gi 1238944359 179 CPTGAIHFGSKED 191
Cdd:cd10555   212 CVGRIRFVGYLDD 224
PRK09898 PRK09898
ferredoxin-like protein;
39-194 9.79e-19

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 82.58  E-value: 9.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  39 CIGCKACQVACSEWND-------IRDEVGNNVGVYDNpadltakswtvmrfsEVEQNDKL--EWLIRKDGCMHCADPGCL 109
Cdd:PRK09898   68 CTGCHRCEISCTNFNDgsvgtffSRIKIHRNYFFGDN---------------GVGSGGGLygDLNYTADTCRQCKEPQCM 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 110 KACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCvdrvtvgqePACVKTCPTGAIHFGSK 189
Cdd:PRK09898  133 NVCPIGAITWQQKEGCITVDHKRCIGCSACTTACPWMMATVNTESKKSSKCVLC---------GECANACPTGALKIIEW 203


                  ....*
gi 1238944359 190 EDMKT 194
Cdd:PRK09898  204 KDITV 208
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 33-185 1.13e-17

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 77.73  E-value: 1.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVACSEWNDIRDEVGNNVGVYDNpadltakswtvmrfseveqndkleWLIrKDGCMHCADPGCLKAC 112
Cdd:cd16367    15 VIDLDRCIRCDNCEKACADTHDGHSRLDRNGLRFGN------------------------LLV-PTACRHCVDPVCMIGC 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238944359 113 PaEGAIIQYANGIVdFQSEQCIGCGYCIAGCPFNVPRLnpedNRVYKCTLCVDrvtvGQEPACVKTCPTGAIH 185
Cdd:cd16367    70 P-TGAIHRDDGGEV-VISDACCGCGNCASACPYGAIQM----VRAVKCDLCAG----YAGPACVSACPTGAAI 132
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 35-199 4.16e-16

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 78.53  E-value: 4.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  35 DVTTCIGCKACQVACS------EWNDIRDEVGNNVGVYDNpaDLTAKSWTvmrfseveqndklewlirkdgCMHCADPGC 108
Cdd:PRK12809    8 EAAECIGCHACEIACAvahnqeNWPLSHSDFRPRIHVVGK--GQAANPVA---------------------CHHCNNAPC 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 109 LKACPAEGAIiqYANGIVDFQSEQCIGCGYCIAGCPFNVPRLnpEDNRVYKCTLCVDRVTvGQEpACVKTCPTGAIHFGS 188
Cdd:PRK12809   65 VTACPVNALT--FQSDSVQLDEQKCIGCKRCAIACPFGVVEM--VDTIAQKCDLCNQRSS-GTQ-ACIEVCPTQALRLMD 138

                         170
                  ....*....|.
gi 1238944359 189 KEDMKTLASER 199
Cdd:PRK12809  139 DKGLQQIKVAR 149
NarH_beta-like cd10557
beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes ...
 100-179 3.90e-15

beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes nitrate reductase A, a member of the DMSO reductase family. The respiratory nitrate reductase complex (NarGHI) from E. coli is a heterotrimer, with the catalytic subunit (NarG) with a molybdo-bis (molybdopterin guanine dinucleotide) cofactor and an [Fe-S] cluster, the electron transfer subunit (NarH) with four [Fe-S] clusters, and the integral membrane subunit (NarI) with two b-type hemes. Nitrate reductase A often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Electron transfer from formate to nitrate is coupled to proton translocation across the cytoplasmic membrane generating proton motive force by a redox loop mechanism. Demethylmenaquinol (DMKH2) has been shown to be a good substrate for NarGHI in nitrate respiration in E. coli.


Pssm-ID: 319879 [Multi-domain]  Cd Length: 363  Bit Score: 74.71  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 100 CMHCADPGCLKACPAeGAIIQYA-NGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKT 178
Cdd:cd10557   179 CNHCLNPACVAACPS-GAIYKREeDGIVLIDQDRCRGWRMCVSACPYKKVYYNWKTGKSEKCIFCYPRLEAGQPTVCSET 257


                  .
gi 1238944359 179 C 179
Cdd:cd10557   258 C 258
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 100-184 2.28e-13

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 65.76  E-value: 2.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 100 CMHCADPGCLKACPaEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCvdrvtvgqePACVKTC 179
Cdd:cd16370    53 CRACEDPPCAEACP-TGALEPRKGGGVVLDKEKCIGCGNCVKACIVGAIFWDEETNKPIICIHC---------GYCARYC 122


                  ....*
gi 1238944359 180 PTGAI 184
Cdd:cd16370   123 PHDVL 127
NarY COG1140
Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and ...
 100-179 2.59e-12

Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440755 [Multi-domain]  Cd Length: 485  Bit Score: 66.75  E-value: 2.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 100 CMHCADPGCLKACPAeGAIIQYA-NGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKT 178
Cdd:COG1140   182 CEHCLNPACVASCPS-GAIYKREeDGIVLVDQDKCRGWRMCVSGCPYKKVYFNWKTGKAEKCIFCYPRIEAGQPTVCSET 260


                  .
gi 1238944359 179 C 179
Cdd:COG1140   261 C 261
SER_beta cd10556
Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate ...
 100-180 3.68e-12

Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate reductase (SER), a member of the DMSO reductase family. SER catalyzes the reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor. The enzyme comprises three subunits SerABC, forming a heterotrimer, with the catalytic component (alpha-subunit), iron-sulfur protein (beta-subunit) and monomeric b-type heme-containing gamma subunit. Beta subunit contains coordinating one [3Fe-4S] cluster and three [4Fe-4S] clusters and functions as electron carrier.


Pssm-ID: 319878 [Multi-domain]  Cd Length: 287  Bit Score: 65.56  E-value: 3.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 100 CMHCADPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVTVGQEPACVKTC 179
Cdd:cd10556   141 CNHCTYPACLAACPRKAIYKREEDGIVLIDQERCRGYRECVEACPYKKPMYNPTTRVSEKCIGCYPRIEEGDQTQCVSAC 220


                  .
gi 1238944359 180 P 180
Cdd:cd10556   221 I 221
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 34-184 7.65e-12

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 61.58  E-value: 7.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  34 IDVTTCIGCKACQVACSE-WNDIRDevgnnvgvydnpadlTAKSwtVMRFSEVEQNDKLewlirkDGCMHCADpgCLKAC 112
Cdd:cd16372     5 TDPEKCIGCLQCEEACSKtFFKEED---------------REKS--CIRITETEGGYAI------NVCNQCGE--CIDVC 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1238944359 113 PaEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCvdrvtvgqePACVKTCPTGAI 184
Cdd:cd16372    60 P-TGAITRDANGVVMINKKLCVGCLMCVGFCPEGAMFKHEDYPEPFKCIAC---------GICVKACPTGAL 121
PRK10330 PRK10330
electron transport protein HydN;
33-199 2.17e-11

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 61.44  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  33 LIDVTTCIGCKACQVAC----SEWNDIrdevgnnvgvydnpADLTAKSWtVMRFSEVEQNDKLEWLIrkdgCMHCADPGC 108
Cdd:PRK10330    6 IADASKCIGCRTCEVACvvshQENQDC--------------ASLTPETF-LPRIHVIKGVNVSTATV----CRQCEDAPC 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 109 LKACPaEGAIIQyANGIVDFQSEQCIGCGYCIAGCPFNVPRL---------------NPEDNRVYKCTLCVDRVTvgqEP 173
Cdd:PRK10330   67 ANVCP-NGAISR-DKGFVHVMQERCIGCKTCVVACPYGAMEVvvrpvirnsgaglnvRAEKAEANKCDLCNHRED---GP 141

                         170       180
                  ....*....|....*....|....*.
gi 1238944359 174 ACVKTCPTGAIHFGSKEDMKTLASER 199
Cdd:PRK10330  142 ACMAACPTHALICVDRNKLEQLSAEK 167
Form-deh_trans pfam09163
Formate dehydrogenase N, transmembrane; Members of this family are predominantly found in the ...
 246-288 1.07e-10

Formate dehydrogenase N, transmembrane; Members of this family are predominantly found in the beta subunit of formate dehydrogenase, and consist of a single transmembrane helix. They act as a transmembrane anchor, and allow for conduction of electrons within the protein.


Pssm-ID: 430440  Cd Length: 43  Bit Score: 55.71  E-value: 1.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1238944359 246 ISETVKFWKGVWKPLAAFGFAATFAASVFHYVGVGPNRAEEED 288
Cdd:pfam09163   1 ISPSVELWKGVLKPLGAAGMGAAALAGFFHYITVGPNKVEEEE 43
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 96-185 3.95e-08

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 53.07  E-value: 3.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  96 RKDGCMHCADpgCLKACPAeGAIIQYANGI--VDfqSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTL---CVDRVTVG 170
Cdd:COG2878   135 CEYGCIGCGD--CIKACPF-DAIVGAAKGMhtVD--EDKCTGCGLCVEACPVDCIEMVPVSPTVVVSSWdkgKAVRKVVG 209

                          90
                  ....*....|....*
gi 1238944359 171 QEPACVKTCPTGAIH 185
Cdd:COG2878   210 CIGLCCKKCCPAAAI 224
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
131-202 2.24e-07

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 47.42  E-value: 2.24e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238944359 131 EQCIGCGYCIAGCPFNVPRLnpEDNRVY----KCTLCvdrvtvgqePACVKTCPTGAIHFGSKEDMKTlaSERVAE 202
Cdd:COG2768    11 EKCIGCGACVKVCPVGAISI--EDGKAVidpeKCIGC---------GACIEVCPVGAIKIEWEEDEEF--QEKMAE 73
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 121-190 2.80e-07

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 47.03  E-value: 2.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238944359 121 YANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRV---YKCTLCVdrvtvgqepACVKTCPTGAIHFGSKE 190
Cdd:COG1149     1 VKRKIPVIDEEKCIGCGLCVEVCPEGAIKLDDGGAPVvdpDLCTGCG---------ACVGVCPTGAITLEERE 64
NapF COG1145
Ferredoxin [Energy production and conversion];
89-190 4.13e-07

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 50.11  E-value: 4.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  89 DKLEWLIRKDGCMHCADPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVY----KCTLCv 164
Cdd:COG1145   140 AEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDGKPQIVvdpdKCIGC- 218

                          90       100
                  ....*....|....*....|....*.
gi 1238944359 165 drvtvgqePACVKTCPTGAIHFGSKE 190
Cdd:COG1145   219 --------GACVKVCPVGAISLEPKE 236
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
95-185 5.29e-07

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 50.41  E-value: 5.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  95 IRKDGCMHCADPGCLKACPAEG----AIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNpeDNRVY----KCTLCvdr 166
Cdd:COG4624    51 CPRCCLCCCCCCRCCVAISCIQvrgiIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVD--DGKAEideeKCISC--- 125

                          90
                  ....*....|....*....
gi 1238944359 167 vtvGQepaCVKTCPTGAIH 185
Cdd:COG4624   126 ---GQ---CVAVCPFGAIT 138
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
99-202 9.18e-07

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 49.16  E-value: 9.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  99 GCMHCADpgCLKACPAEGAIIQyaNGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVY-------------------- 158
Cdd:PRK07118  140 GCLGLGS--CVAACPFDAIHIE--NGLPVVDEDKCTGCGACVKACPRNVIELIPKSARVFvacnskdkgkavkkvcevgc 215

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1238944359 159 -KCTLCV------------DRVTVGQEP-----ACVKTCPTGAIHFGSKEDMKTLASERVAE 202
Cdd:PRK07118  216 iGCGKCVkacpagaitmenNLAVIDQEKctscgKCVEKCPTKAIRILNKPPKVKEPKKAAAE 277
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 131-193 1.39e-06

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 45.09  E-value: 1.39e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1238944359 131 EQCIGCGYCIAGCPFNVPRLNPEDNRVY-----KCTLCvdrvtvgqePACVKTCPTGAIHFGSKEDMK 193
Cdd:COG1146     8 DKCIGCGACVEVCPVDVLELDEEGKKALvinpeECIGC---------GACELVCPVGAITVEDDEPEE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 127-187 1.71e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 46.24  E-value: 1.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1238944359 127 DFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVY-------KCTLCvdrvtvGqepACVKTCPTGAIHFG 187
Cdd:cd10549     2 KYDPEKCIGCGICVKACPTDAIELGPNGAIARgpeidedKCVFC------G---ACVEVCPTGAIELT 60
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
125-193 2.29e-06

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 48.13  E-value: 2.29e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1238944359 125 IVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRvYKCTLCvdrvtvGqepACVKTCPTGAIHFGSKEDMK 193
Cdd:COG0348   204 RVRYDRGDCIDCGLCVKVCPMGIDIRKGEINQ-SECINC------G---RCIDACPKDAIRFSSRGEKT 262
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 130-189 3.92e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 47.16  E-value: 3.92e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238944359 130 SEQCIGCGYCIAGCPFNVPRLnpEDNRVY---KCTLCVdrvtvgqepACVKTCPTGAIHFGSK 189
Cdd:NF038196  184 TDKCIGCGICAKVCPVNNIEM--EDGKPVwghNCTHCL---------ACIHRCPKEAIEYGKK 235
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
94-154 6.94e-06

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 43.18  E-value: 6.94e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1238944359  94 LIRKDGCMHCADpgCLKACPAEgaIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPED 154
Cdd:COG2768     7 YVDEEKCIGCGA--CVKVCPVG--AISIEDGKAVIDPEKCIGCGACIEVCPVGAIKIEWEE 63
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 97-185 7.90e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 44.31  E-value: 7.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  97 KDGCMHCADpgCLKACPAeGAIIQYANGIV----DFQSEQCIGCGYCIAGCPFNVPRLNPEdnrvYKCTLCVDRVTVGQE 172
Cdd:cd10549     5 PEKCIGCGI--CVKACPT-DAIELGPNGAIargpEIDEDKCVFCGACVEVCPTGAIELTPE----GKEYVPKEKEAEIDE 77

                          90
                  ....*....|....*....
gi 1238944359 173 P------ACVKTCPTGAIH 185
Cdd:cd10549    78 EkcigcgLCVKVCPVDAIT 96
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 131-190 9.11e-06

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 42.81  E-value: 9.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238944359 131 EQCIGCGYCIAGCPFNVPRLNPEDNRVY------KCTLCVdrvtvgqepACVKTCPTGAIHFGSKE 190
Cdd:COG1143     2 DKCIGCGLCVRVCPVDAITIEDGEPGKVyvidpdKCIGCG---------LCVEVCPTGAISMTPFE 58
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
131-186 1.09e-05

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 46.78  E-value: 1.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 131 EQCIGCGYCIAGCPFNVPRLNpEDNRVY----KCTLCvdrvtvGqepACVKTCPTGAIHF 186
Cdd:COG1148   496 EKCTGCGRCVEVCPYGAISID-EKGVAEvnpaLCKGC------G---TCAAACPSGAISL 545
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 93-144 1.32e-05

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 41.85  E-value: 1.32e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1238944359  93 WLIRKDGCMHCADpgCLKACPAEGAI-----IQYANGIVDFQSEQCIGCGYCIAGCP 144
Cdd:pfam13237   2 VVIDPDKCIGCGR--CTAACPAGLTRvgaivERLEGEAVRIGVWKCIGCGACVEACP 56
Fer4_9 pfam13187
4Fe-4S dicluster domain;
132-184 1.74e-05

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 41.39  E-value: 1.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1238944359 132 QCIGCGYCIAGCPF------NVPRLNPEDNRVYKCTLCVdrvtvgqepACVKTCPTGAI 184
Cdd:pfam13187   1 KCTGCGACVAACPAgaivpdLVGQTIRGDIAGLACIGCG---------ACVDACPRGAI 50
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 124-204 1.75e-05

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 43.29  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 124 GIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVY----KCTLCvdrvtvGQepaCVKTCPTGAIHFGSK---------- 189
Cdd:PRK08348   35 GKILYDVDKCVGCRMCVTVCPAGVFVYLPEIRKVAlwtgRCVFC------GQ---CVDVCPTGALQMSDDfllasydrfd 105

                          90
                  ....*....|....*
gi 1238944359 190 EDMKTLASERVAELK 204
Cdd:PRK08348  106 EKFIPLKPEKVEEIK 120
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 133-194 1.89e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 43.78  E-value: 1.89e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238944359 133 CIGCGYCIAGCPFNV---------------PRLNPEDNrvyKCTLCVDrvtvgqepACVKTCPTGAIHFGSKEDMKT 194
Cdd:cd16373    16 CIRCGLCVEACPTGViqpagledgleggrtPYLDPREG---PCDLCCD--------ACVEVCPTGALRPLDLEEQKV 81
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 95-147 2.55e-05

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 41.58  E-value: 2.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238944359  95 IRKDGCMHCADpgCLKACPaEGAIiQYANGIVDFQSEQCIGCGYCIAGCPFNV 147
Cdd:COG2221    12 IDEEKCIGCGL--CVAVCP-TGAI-SLDDGKLVIDEEKCIGCGACIRVCPTGA 60
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 34-147 2.97e-05

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 42.77  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  34 IDVTTCIGCKACQVACSewndirdevgnnVGVYdnpadltakswTVMRFSEVEQNDKLEWLIRKDGCMHCADpgCLKACP 113
Cdd:cd10549    37 IDEDKCVFCGACVEVCP------------TGAI-----------ELTPEGKEYVPKEKEAEIDEEKCIGCGL--CVKVCP 91

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1238944359 114 aEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNV 147
Cdd:cd10549    92 -VDAITLEDELEIVIDKEKCIGCGICAEVCPVNA 124
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
84-146 4.13e-05

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 44.63  E-value: 4.13e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  84 EVEQNDKLEWLIRKDGCMHCADPG-------CLKACPAEgaIIQYANGIVDFQSEQCIGCGYCIAGCPFN 146
Cdd:COG4624    68 ISCIQVRGIIIIDKRGPSIIRDKEkckncypCVRACPVK--AIKVDDGKAEIDEEKCISCGQCVAVCPFG 135
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 95-146 4.90e-05

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 40.87  E-value: 4.90e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1238944359  95 IRKDGCMHCADpgCLKACPaEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFN 146
Cdd:COG1149     8 IDEEKCIGCGL--CVEVCP-EGAIKLDDGGAPVVDPDLCTGCGACVGVCPTG 56
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 117-185 5.23e-05

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 40.80  E-value: 5.23e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238944359 117 AIIQYANGIVDfqSEQCIGCGYCIAGCPFNVprLNPEDNRVY----KCTLCvdrvtvgqePACVKTCPTGAIH 185
Cdd:COG2221     3 GIIGTWPPKID--EEKCIGCGLCVAVCPTGA--ISLDDGKLVideeKCIGC---------GACIRVCPTGAIK 62
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 133-183 1.19e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 39.05  E-value: 1.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 133 CIGCGYCIAGCPFNVPRLNPEDN---------RVYKCTLCvdrvtvgqePACVKTCPTGA 183
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEkkgtktvviDPERCVGC---------GACVAVCPTGA 51
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 131-184 3.32e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 38.49  E-value: 3.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1238944359 131 EQCIGCGYCIAGCPFNVprLNPEDNRVY----KCTLCVdrvtvgqepACVKTCPTGAI 184
Cdd:COG4231    22 DKCTGCGACVKVCPADA--IEEGDGKAVidpdLCIGCG---------SCVQVCPVDAI 68
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 98-186 3.94e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 39.92  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  98 DGCMHCADpgCLKACPaEGAIIQYANGI--VDFQSEQCIGCGYCIAGCPFNVPRLNPED---------------NRVYkC 160
Cdd:cd10564    13 DLCTRCGD--CVEACP-EGIIVRGDGGFpeLDFSRGECTFCGACAEACPEGALDPAREApwplraeigdsclalQGVE-C 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1238944359 161 TLCVD---------RVTVG--QEP-----------ACVKTCPTGAIHF 186
Cdd:cd10564    89 RSCQDacptqairfRPRLGgiALPeldadactgcgACVSVCPVGAITL 136
flavo_MJ0208 TIGR02700
archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of ...
 90-146 4.84e-04

archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General]


Pssm-ID: 131747 [Multi-domain]  Cd Length: 234  Bit Score: 40.63  E-value: 4.84e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1238944359  90 KLEWLIRKDGCMHCADpgCLKACPAEGaiIQYANGIVDFQSEQCIGCGYCIAGCPFN 146
Cdd:TIGR02700 140 ITPYMIDRKRCKGCGI--CVDACPRSA--IDMVDGKAFIRLLKCVGCGKCKEACPYN 192
napG PRK09476
quinol dehydrogenase periplasmic component; Provisional
 127-183 5.42e-04

quinol dehydrogenase periplasmic component; Provisional


Pssm-ID: 236534 [Multi-domain]  Cd Length: 254  Bit Score: 40.76  E-value: 5.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1238944359 127 DFQSeQCIGCGYCIAGCPFNVPRL-NPEDN----------RVYKCTLCVDrvtvgqePACVKTCPTGA 183
Cdd:PRK09476   56 DFLS-ACIRCGLCVQACPYDTLKLaTLASGlsagtpyfvaRDIPCEMCED-------IPCVKACPSGA 115
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
95-151 7.27e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 41.00  E-value: 7.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1238944359  95 IRKDGCMHCAdpGCLKACPAeGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLN 151
Cdd:COG1148   493 VDPEKCTGCG--RCVEVCPY-GAISIDEKGVAEVNPALCKGCGTCAAACPSGAISLK 546
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 100-147 7.56e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 36.74  E-value: 7.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238944359 100 CMHCADpgCLKACPA-----EGAIIQYANGIVDFQSEQCIGCGYCIAGCPFNV 147
Cdd:pfam12838   1 CIGCGA--CVAACPVgaitlDEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 95-146 8.19e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 37.33  E-value: 8.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1238944359  95 IRKDGCMHCADpgCLKACPAEgaIIQYANGIVDFQSEQCIGCGYCIAGCPFN 146
Cdd:COG4231    19 IDEDKCTGCGA--CVKVCPAD--AIEEGDGKAVIDPDLCIGCGSCVQVCPVD 66
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 94-153 9.16e-04

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 39.40  E-value: 9.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  94 LIRKDGCMHCADpgCLKACPAEgAIIQYANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPE 153
Cdd:TIGR01944 109 LIDEDNCIGCTK--CIQACPVD-AIVGAAKAMHTVIADECTGCDLCVEPCPTDCIEMIPV 165
Fer COG1141
Ferredoxin [Energy production and conversion];
131-185 1.84e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440756 [Multi-domain]  Cd Length: 63  Bit Score: 36.01  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1238944359 131 EQCIGCGYCIAGCPfNVPRLNPEDnrvyKCTLCVDRVTVGQEPAC---VKTCPTGAIH 185
Cdd:COG1141     8 DTCIGCGLCVALAP-EVFELDDDG----KAVVLDEEVPEELEEDVreaADACPVGAIT 60
PRK13795 PRK13795
hypothetical protein; Provisional
 94-144 1.94e-03

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 39.59  E-value: 1.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238944359  94 LIRKDGCMHCadpG-CLKACPaEGAI-IQYANGIVDFQSEQCIGCGYCIAGCP 144
Cdd:PRK13795  577 LRRAAECVGC---GvCVGACP-TGAIrIEEGKRKISVDEEKCIHCGKCTEVCP 625
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 95-146 2.09e-03

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 36.57  E-value: 2.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1238944359  95 IRKDGCMHCADpgCLKACPaEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFN 146
Cdd:COG1144    27 VDEDKCIGCGL--CWIVCP-DGAIRVDDGKYYGIDYDYCKGCGICAEVCPVK 75
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 128-184 2.72e-03

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 36.18  E-value: 2.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1238944359 128 FQSEQCIGCGYCIAGCPFNVprLNPEDNRVY-----KCTLCvdrvtvgqePACVKTCPTGAI 184
Cdd:COG1144    27 VDEDKCIGCGLCWIVCPDGA--IRVDDGKYYgidydYCKGC---------GICAEVCPVKAI 77
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
123-186 3.35e-03

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 36.94  E-value: 3.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238944359 123 NGIVDFQSEQCIGCGYCIAGCPFN---------VPRL----NPEDNRVYKCTLCVDRvtvgqepACVKTCPTGAIHF 186
Cdd:COG1142     2 NKFIIADPEKCIGCRTCEAACAVAhegeegepfLPRIrvvrKAGVSAPVQCRHCEDA-------PCAEVCPVGAITR 71
Fer4_13 pfam13370
4Fe-4S single cluster domain of Ferredoxin I; Fer4_13 is a ferredoxin I from sulfate-reducing ...
 131-185 3.92e-03

4Fe-4S single cluster domain of Ferredoxin I; Fer4_13 is a ferredoxin I from sulfate-reducing bacteria. Chemical sequence analysis suggests that this characteriztic [4Fe-4S] cluster sulfur environment is widely distributed among ferredoxins.


Pssm-ID: 433153 [Multi-domain]  Cd Length: 58  Bit Score: 34.97  E-value: 3.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359 131 EQCIGCGYCIAGCPfNVPRLNPEDNRVYkctlcVDRVTVGQ-EPACVK----TCPTGAIH 185
Cdd:pfam13370   4 DTCIDCGTCRELAP-EVFKYDDDGGASF-----VHDQPVNEeEEDLAEealdSCPVEAIG 57
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
99-168 4.62e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 37.99  E-value: 4.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238944359  99 GCMHCADpgCLKACPAeGAIIQyANGIVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYKCTLCVDRVT 168
Cdd:PRK07118  214 GCIGCGK--CVKACPA-GAITM-ENNLAVIDQEKCTSCGKCVEKCPTKAIRILNKPPKVKEPKKAAAEAA 279
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 131-188 8.80e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 35.75  E-value: 8.80e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238944359 131 EQCIGCGYCIAGCP---FNVPRLNPEDNRV------YKCTLCVDrvtvgqePACVKTCPTGAIHFGS 188
Cdd:cd16367    19 DRCIRCDNCEKACAdthDGHSRLDRNGLRFgnllvpTACRHCVD-------PVCMIGCPTGAIHRDD 78
Fer4_9 pfam13187
4Fe-4S dicluster domain;
108-147 9.60e-03

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 33.68  E-value: 9.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1238944359 108 CLKACPAeGAIIQYANG---IVDFQSEQCIGCGYCIAGCPFNV 147
Cdd:pfam13187   8 CVAACPA-GAIVPDLVGqtiRGDIAGLACIGCGACVDACPRGA 49
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 97-159 9.65e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 34.34  E-value: 9.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238944359  97 KDGCMHCADpgCLKACPAeGAIIQYANG---IVDFQSEQCIGCGYCIAGCPFNVPRLNPEDNRVYK 159
Cdd:COG1143     1 EDKCIGCGL--CVRVCPV-DAITIEDGEpgkVYVIDPDKCIGCGLCVEVCPTGAISMTPFELAVED 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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