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Conserved domains on  [gi|1242338128|gb|PBG76259|]
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GntR family transcriptional regulator [Clostridioides difficile]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-231 5.15e-50

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 163.11  E-value: 5.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   4 NQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAE 83
Cdd:COG2188     3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  84 SFSSILLSKGHKLSKKTISIEKIinDTNSQVFSIF----GEKCSKITRMYYLDSKPYIFFTHYIPFD--ENLTVESFNNE 157
Cdd:COG2188    83 SFTEELRARGREPSTRVLSAERV--PADEEVAEALglppGAPVLRIERLRLADGEPVALETSYLPAAlfPGLLEEDLETG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1242338128 158 sSLYMYLYRR-NINITRFEDEFFIEESELEVSKALNLAK-DILLGRKRKTYDENDNIVELSFARYNTEVQNYVIKY 231
Cdd:COG2188   161 -SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPgAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-231 5.15e-50

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 163.11  E-value: 5.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   4 NQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAE 83
Cdd:COG2188     3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  84 SFSSILLSKGHKLSKKTISIEKIinDTNSQVFSIF----GEKCSKITRMYYLDSKPYIFFTHYIPFD--ENLTVESFNNE 157
Cdd:COG2188    83 SFTEELRARGREPSTRVLSAERV--PADEEVAEALglppGAPVLRIERLRLADGEPVALETSYLPAAlfPGLLEEDLETG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1242338128 158 sSLYMYLYRR-NINITRFEDEFFIEESELEVSKALNLAK-DILLGRKRKTYDENDNIVELSFARYNTEVQNYVIKY 231
Cdd:COG2188   161 -SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPgAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-70 5.99e-25

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 93.28  E-value: 5.99e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1242338128   6 PLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK11402 PRK11402
transcriptional regulator PhoB;
5-222 6.29e-21

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 87.58  E-value: 6.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   5 QPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAES 84
Cdd:PRK11402    8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  85 FSSILLSKGHKLSKKTISIEKIINDTNSQVFSIFGE-KCSKITRMYYLDSKPYIFFTHYIPFDENLTVESFNNESSLYMY 163
Cdd:PRK11402   88 FTDFGVSQGKATKEKVIEQERVSAAPFCEKLNIPGNsEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGSSTYQ 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1242338128 164 LYRRNINITRFEDEFFIEESELEVSKALNLAKDI--LLGRKRKT-YDENDNIVELSFARYNT 222
Cdd:PRK11402  168 LFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELgePLFRISKIaFDQNDKPVHVSELFCRA 229
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-70 6.47e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 77.65  E-value: 6.47e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1242338128   7 LYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
11-70 1.44e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 68.37  E-value: 1.44e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   11 VVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 8-164 3.58e-13

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 66.23  E-value: 3.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   8 YIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFN-KLSKAESFS 86
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEfPISGITSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  87 SILLSKGHKLSKKTISIEK-IINDTNSQVFSIFGEK--CSKITRMYYLDSKPYIFFTHYI--PFDENLTVESFnnESSLY 161
Cdd:TIGR02404  82 ELNETLGLDSKTEVVELDKeDPLPETLAQLTGLEEGslIWRIKRVRVIDGEAVILDIDYLlkELVPGLTKEIA--EDSIY 159


                  ...
gi 1242338128 162 MYL 164
Cdd:TIGR02404 160 QYL 162
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-231 5.15e-50

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 163.11  E-value: 5.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   4 NQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAE 83
Cdd:COG2188     3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  84 SFSSILLSKGHKLSKKTISIEKIinDTNSQVFSIF----GEKCSKITRMYYLDSKPYIFFTHYIPFD--ENLTVESFNNE 157
Cdd:COG2188    83 SFTEELRARGREPSTRVLSAERV--PADEEVAEALglppGAPVLRIERLRLADGEPVALETSYLPAAlfPGLLEEDLETG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1242338128 158 sSLYMYLYRR-NINITRFEDEFFIEESELEVSKALNLAK-DILLGRKRKTYDENDNIVELSFARYNTEVQNYVIKY 231
Cdd:COG2188   161 -SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPgAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-70 5.99e-25

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 93.28  E-value: 5.99e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1242338128   6 PLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK11402 PRK11402
transcriptional regulator PhoB;
5-222 6.29e-21

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 87.58  E-value: 6.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   5 QPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAES 84
Cdd:PRK11402    8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  85 FSSILLSKGHKLSKKTISIEKIINDTNSQVFSIFGE-KCSKITRMYYLDSKPYIFFTHYIPFDENLTVESFNNESSLYMY 163
Cdd:PRK11402   88 FTDFGVSQGKATKEKVIEQERVSAAPFCEKLNIPGNsEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGSSTYQ 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1242338128 164 LYRRNINITRFEDEFFIEESELEVSKALNLAKDI--LLGRKRKT-YDENDNIVELSFARYNT 222
Cdd:PRK11402  168 LFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELgePLFRISKIaFDQNDKPVHVSELFCRA 229
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
2-74 1.50e-19

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 83.83  E-value: 1.50e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1242338128   2 LRNQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNS 74
Cdd:COG2186     3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPS 75
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-70 6.47e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 77.65  E-value: 6.47e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1242338128   7 LYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
4-70 4.04e-18

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 76.76  E-value: 4.04e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1242338128   4 NQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:COG1725     8 GVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFV 74
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
11-70 1.44e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 68.37  E-value: 1.44e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   11 VVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK09764 PRK09764
GntR family transcriptional regulator;
4-223 5.10e-15

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 71.78  E-value: 5.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   4 NQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAE 83
Cdd:PRK09764    3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  84 SFSSiLLSKGHKLSKKTISIEKII--NDTNSQVFSIF-GEKCSKITRMYYLDSKPYIFFTHYIPFD--ENLTVESFnnES 158
Cdd:PRK09764   83 SFDE-KLSDRHVDTHSEVLIFEVIpaDDFLQQQLQITaQDRVWHVKRVRYRKQKPMALEETWMPLAlfPDLTWQVM--EN 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1242338128 159 SLYMYLYR-RNINITRFEDEFFIEESELEVSKALNL--AKDILLGRKRKtYDENDNIVELSFARYNTE 223
Cdd:PRK09764  160 SKYHFIEEvKKMVIDRSEQEIIPLMPTEEMSRLLNIsqTKPILEKVSRG-YLVDGRVFEYSRNAFNTD 226
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 93-223 1.98e-14

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 68.01  E-value: 1.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  93 GHKLSKKTISIEKII-NDTNSQVFSI-FGEKCSKITRMYYLDSKPYIFFTHYIPFD--ENLTVESFNNEsSLYMYLYRR- 167
Cdd:pfam07702   3 GREPKTEVLSLEEVPaSAEIAEALGLpPGEPVYRIERLRYADGEPVALEEDYLPAElvPDLLEEDLEEG-SLYDYLEERy 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1242338128 168 NINITRFEDEFFIEESELEVSKALNLAK-DILLGRKRKTYDENDNIVELSFARYNTE 223
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPgAPVLLIERVTYDQDGRPVEYSRSYYRGD 138
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 3-70 9.16e-14

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 69.86  E-value: 9.16e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1242338128   3 RNQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:COG1167     9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFV 76
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-223 1.24e-13

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 65.78  E-value: 1.24e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   91 SKGHKLSKKTISIEKIINDTN-SQVFSI-FGEKCSKITRMYYLDSKPYIFFTHYIPFD--ENLTVESFnnESSLYMYLYR 166
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEElAEALGLpPGDPVYRIERLRLADGEPVALETTYLPAAlfPGLLEEDL--SGSLYEYLEE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1242338128  167 RN----INITRFEDEFFIEESELEVSKALNLAK-DILLGRKRKTYDENDNIVELSFARYNTE 223
Cdd:smart00866  79 RLglkiVRSTRAEQTITAVLADEEEAELLGLPPgAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 8-164 3.58e-13

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 66.23  E-value: 3.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   8 YIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFN-KLSKAESFS 86
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEfPISGITSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  87 SILLSKGHKLSKKTISIEK-IINDTNSQVFSIFGEK--CSKITRMYYLDSKPYIFFTHYI--PFDENLTVESFnnESSLY 161
Cdd:TIGR02404  82 ELNETLGLDSKTEVVELDKeDPLPETLAQLTGLEEGslIWRIKRVRVIDGEAVILDIDYLlkELVPGLTKEIA--EDSIY 159


                  ...
gi 1242338128 162 MYL 164
Cdd:TIGR02404 160 QYL 162
PRK11523 PRK11523
transcriptional regulator ExuR;
7-73 3.10e-12

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 64.10  E-value: 3.10e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1242338128   7 LYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISN 73
Cdd:PRK11523    9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSN 75
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 7-93 1.02e-11

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 62.49  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   7 LYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAESFS 86
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88


                  ....*..
gi 1242338128  87 SILLSKG 93
Cdd:TIGR02325  89 QNLADQG 95
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-70 6.19e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 59.94  E-value: 6.19e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   1 MLRNQPLYIQVVDILKQKILNNEYKIDENIpTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:COG1802     6 PLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV 74
PRK10225 PRK10225
Uxu operon transcriptional regulator;
8-84 6.74e-08

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 51.56  E-value: 6.74e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1242338128   8 YIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAES 84
Cdd:PRK10225   11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDSPDA 87
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
15-80 1.86e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 50.40  E-value: 1.86e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1242338128  15 LKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKViSNSLFNKLS 80
Cdd:PRK09464   19 LEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV-QSSLWQSFS 83
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 10-70 2.38e-07

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 50.15  E-value: 2.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1242338128  10 QVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:PRK10421    6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-91 5.99e-07

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 48.87  E-value: 5.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   1 MLRNQP-----LYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVI---S 72
Cdd:PRK03837    3 NLRSRPiarkkLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSrpsA 82

                          90
                  ....*....|....*....
gi 1242338128  73 NSLFNKLSKAesfSSILLS 91
Cdd:PRK03837   83 DTIIGQLSGM---AKDFLS 98
PRK14999 PRK14999
histidine utilization repressor; Provisional
 6-106 2.25e-06

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 47.23  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   6 PLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAESF 85
Cdd:PRK14999   12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSI 91

                          90       100
                  ....*....|....*....|.
gi 1242338128  86 SSILLSKGHKLSKKTISIEKI 106
Cdd:PRK14999   92 AEEIAARRHQHRCEVLTLERV 112
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 7-216 2.08e-05

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 44.38  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128   7 LYIQVVDILKQKiLNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAESFS 86
Cdd:PRK10079   13 RYQEIAAKLEQE-LRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242338128  87 SILLSKG-HKLSKKTISIEKIINDTNSQVFSIF-GEKCSKITRMYYLDSKPYIFFTHYIPfdeNLT----VESFNNeSSL 160
Cdd:PRK10079   92 QNLLDQGsHPTSEKLLSVLRPASGHVADALGITeGENVIHLRTLRRVNGVALCLIDHYFA---DLTwwptLQRFDS-GSL 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1242338128 161 YMYLYRR-NINITRFEDEFFIEESELEVSKALNLA--KDILLGRKRKTYDENDNIVELS 216
Cdd:PRK10079  168 HDFLREQlGIALRRSQTRISARRAQAKESQLLEIPnmSPLLCVRTLNHRDGESSPAEYS 226
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 35-67 1.35e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 35.87  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1242338128  35 ELEQEFGVSKITIRKAIEILESEGY-VEKKSGKG 67
Cdd:pfam08279  18 ELAEKLGVSRRTIRRDIKILEELGVpIEAEPGRG 51
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 35-65 3.00e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 37.81  E-value: 3.00e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1242338128  35 ELEQEFGVSKITIRKAIEILESEGYVEKKSG 65
Cdd:COG1349    24 ELAERLGVSEETIRRDLAELEEQGLLRRVHG 54
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 10-70 3.50e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 37.82  E-value: 3.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1242338128  10 QVVDILKQKILNNEYKIDENIPTERELEQEFGVSKITIRKAIEILESEGYVEKKSGKGTKV 70
Cdd:PRK09990   11 VVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
BirA COG1654
Biotin operon repressor [Transcription];
35-67 7.45e-03

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 36.89  E-value: 7.45e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1242338128  35 ELEQEFGVSKITIRKAIEILESEGY-VEKKSGKG 67
Cdd:COG1654    23 ELAEELGVSRAAVWKHIKALRELGYeIESVPGKG 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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