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Conserved domains on  [gi|1244976209|gb|PBW08828|]
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MFS transporter [Pseudomonas aeruginosa]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-220 1.42e-44

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17393:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 373  Bit Score: 152.80  E-value: 1.42e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209   1 MIGQDFALSTHFGVISVIAFLAALACWRFL-------HDQPGAERVGRAFTMPDRRLFNYGLIVFFSMACEGIMYDWSVV 73
Cdd:cd17393   145 AIGAGVSPGVHLLAAAVLLLLAALVAIRALlpgtgeaAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSAL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  74 YFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICT 153
Cdd:cd17393   225 YLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSV 304

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1244976209 154 VIPLVAGAAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIILRAG 220
Cdd:cd17393   305 VVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLAR 371
 
Name Accession Description Interval E-value
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 1-220 1.42e-44

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 152.80  E-value: 1.42e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209   1 MIGQDFALSTHFGVISVIAFLAALACWRFL-------HDQPGAERVGRAFTMPDRRLFNYGLIVFFSMACEGIMYDWSVV 73
Cdd:cd17393   145 AIGAGVSPGVHLLAAAVLLLLAALVAIRALlpgtgeaAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSAL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  74 YFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICT 153
Cdd:cd17393   225 YLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSV 304

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1244976209 154 VIPLVAGAAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIILRAG 220
Cdd:cd17393   305 VVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLAR 371
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
12-222 1.77e-31

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 118.42  E-value: 1.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  12 FGVISVIAFLAALACWRFL-------HDQPGAERVGRAFTMPDRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVVSAERQ 84
Cdd:COG0738   167 YLILAVLLLLLALLFLRSKlpeieeeEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  85 LVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAAR 164
Cdd:COG0738   247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD 326

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1244976209 165 SSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIILRAGKI 222
Cdd:COG0738   327 GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_1 pfam07690
Major Facilitator Superfamily;
55-217 1.94e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  55 LIVFFSMACEGIMYDWSVVYFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAY 134
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 135 PSLLASIIGFCLVGLGICTVIPLVAGAAARSSS-MAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAI 213
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162


                  ....
gi 1244976209 214 GIIL 217
Cdd:pfam07690 163 LAAV 166
 
Name Accession Description Interval E-value
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 1-220 1.42e-44

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 152.80  E-value: 1.42e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209   1 MIGQDFALSTHFGVISVIAFLAALACWRFL-------HDQPGAERVGRAFTMPDRRLFNYGLIVFFSMACEGIMYDWSVV 73
Cdd:cd17393   145 AIGAGVSPGVHLLAAAVLLLLAALVAIRALlpgtgeaAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSAL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  74 YFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICT 153
Cdd:cd17393   225 YLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSV 304

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1244976209 154 VIPLVAGAAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIILRAG 220
Cdd:cd17393   305 VVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLAR 371
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
12-222 1.77e-31

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 118.42  E-value: 1.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  12 FGVISVIAFLAALACWRFL-------HDQPGAERVGRAFTMPDRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVVSAERQ 84
Cdd:COG0738   167 YLILAVLLLLLALLFLRSKlpeieeeEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  85 LVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAAR 164
Cdd:COG0738   247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD 326

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1244976209 165 SSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIILRAGKI 222
Cdd:COG0738   327 GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 2-217 3.97e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 67.57  E-value: 3.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209   2 IGQDFALSTHFGVISVIAFLAALACWRFLHDQPGAERVGRAFTMP------DRRLFNYGLIVFFSMACEGIMYDWSVVYF 75
Cdd:cd17324   146 LGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSlllllrNPRLRLAYLITFLLFGGFFALYTYLAPFL 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  76 QDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVI 155
Cdd:cd17324   226 TDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH 305

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1244976209 156 PLVAGAAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIIL 217
Cdd:cd17324   306 SALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALL 367
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 53-212 2.50e-11

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 62.34  E-value: 2.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  53 YGLIVFFSMACEGIMYDWSVVYFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTI 132
Cdd:cd17333   204 GALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 133 AYPSLLASIIGFCLVGLGICTVIPLVAGAAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLA 212
Cdd:cd17333   284 LAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILY 363
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
54-217 8.24e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 60.65  E-value: 8.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  54 GLIVFFSMACEGIMYDWSVVYFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRS--TLQWSGGLALIGMVTT 131
Cdd:COG2271   186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 132 IAYPSLLASIIGFCLVGLGICTVIPLVAGAAARSSSM-APSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVV 210
Cdd:COG2271   266 ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKkARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345


                  ....*..
gi 1244976209 211 LAIGIIL 217
Cdd:COG2271   346 LALLAAL 352
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 12-213 9.96e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 60.67  E-value: 9.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  12 FGVISVIAFLAALACWRFLHDQPGAE----------RVGRAFTMPDRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVVSA 81
Cdd:cd17325   153 FLVCAALALLALVLALLLLPEPRPPPnkravsaarlRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  82 ERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLV-AG 160
Cdd:cd17325   233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATlAL 312

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1244976209 161 AAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAI 213
Cdd:cd17325   313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLL 365
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 2-216 3.76e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 55.68  E-value: 3.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209   2 IGQDFALSTHFGVISVIAFLAALACWRFLHDQPGAERVGRAFTMPDRRLFNYGLIVF-FSMACEGIMYDwSVVYFQDVVS 80
Cdd:cd17489   143 LYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPaLILFLASIAYG-AISTFLPLYA 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  81 AERQLVGVG--FMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIP-L 157
Cdd:cd17489   222 AERGISNAGlfFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPaL 301

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1244976209 158 VAGAAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLR--YAFGACVVLAIGII 216
Cdd:cd17489   302 QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRamFLLAAVVVLLALVL 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-184 8.44e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.59  E-value: 8.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  12 FGVISVIAFLAALACWRFLHDQPGAERVGRAFTMP----DRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVVSAERQLVG 87
Cdd:COG2814   167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRellrRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  88 VGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAARSSS 167
Cdd:COG2814   247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                         170
                  ....*....|....*...
gi 1244976209 168 M-APSSAIAAVLTIGFLG 184
Cdd:COG2814   327 PeARGRASGLYNSAFFLG 344
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
6-217 6.82e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.19  E-value: 6.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209   6 FALSTHFGVISVIAFLAALACWRFLHDQPGAERVGRAFTMP-------DRRLFNYGLIVFFSMACEGIMYDWSVVYFQDV 78
Cdd:COG2223   156 FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRdqlealrDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  79 VSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYP-SLLASIIGFCLVGLGICTVIPL 157
Cdd:COG2223   236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGA 315

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1244976209 158 VAG-AAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLR----YAFGACVVLAIGIIL 217
Cdd:COG2223   316 VFAlVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYtaafLVFAVLALVALVLTL 380
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
45-217 1.22e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  45 MPDRRLFNYGLIVFFSMACEGIMYDWSVV-----YFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQW 119
Cdd:COG2814     1 MPATPRRRWLALLALALGAFLSGLGIGIVlpalpLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 120 SGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAARSSSMA-PSSAIAAVLTIGFLGTLIGPPLIGFLSEA 198
Cdd:COG2814    81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPErRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                         170
                  ....*....|....*....
gi 1244976209 199 FGLRYAFGACVVLAIGIIL 217
Cdd:COG2814   161 FGWRWVFLVNAVLALLALL 179
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
12-200 3.15e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.29  E-value: 3.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  12 FGVISVIAFLAALACWRFLHDQPGAERVGRAF------TMPDRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVVSAERQL 85
Cdd:COG2211   186 ALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLkeslkaLLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  86 VGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYP--SLLASIIGFCLVGLGICTVIPL------ 157
Cdd:COG2211   266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLpwamla 345

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1244976209 158 -VAGAAARSSSMAPSSAIAAVLT-IGFLGTLIGPPLIGFLSEAFG 200
Cdd:COG2211   346 dVVDYDEWKTGRRREGLYFGIFTfAIKLGQALAGALAGLLLALFG 390
MFS_1 pfam07690
Major Facilitator Superfamily;
55-217 1.94e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  55 LIVFFSMACEGIMYDWSVVYFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAY 134
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 135 PSLLASIIGFCLVGLGICTVIPLVAGAAARSSS-MAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAI 213
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162


                  ....
gi 1244976209 214 GIIL 217
Cdd:pfam07690 163 LAAV 166
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
83-217 2.73e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.18  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  83 RQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAA 162
Cdd:COG2807    52 ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLI 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1244976209 163 ARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIIL 217
Cdd:COG2807   132 KRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALL 186
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
10-227 3.90e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.79  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  10 THFGVISVIAFLAALACWRFLHDQPGAERVGRAFTMP-----DRRLFNYGLIVFFSMACEGIMYDWSVVYFQDV-VSAER 83
Cdd:COG2807   172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLrslwrSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAgLSAAT 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  84 QLVGVGFMVFMGAmtVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAA 163
Cdd:COG2807   252 AGLLLSLFQLAGI--PGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIG 329

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 164 RSSSMAPSSA--IAAVLTIGFLGTLIGPPLIGFLSEAFG----LRYAFGACVVLAIGIILRAGKIPWQAP 227
Cdd:COG2807   330 LRARTPAEAAalSGMAQSVGYLLAALGPLLVGALHDATGswtaALLLLAALAVLMLVAGLLAGRPYVEDA 399
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
87-217 6.72e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.02  E-value: 6.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  87 GVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAARSS 166
Cdd:COG2271    48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1244976209 167 SMA-PSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIIL 217
Cdd:COG2271   128 PPKeRGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL 179
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 11-217 9.26e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 45.62  E-value: 9.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  11 HFGVISVIAFLAALACWRFLHDQPGAERVGRAFTMPDRRLFNYGLIVFFSMACEGIMYDWSV--------VYFQDVVSAE 82
Cdd:cd17478   150 GLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLsslttflpFYLVQRGYSL 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  83 rQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTtIAYPSLLASIIGFCLVGLGICTVIPLVAGAA 162
Cdd:cd17478   230 -VFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL-FLLTPGIWSYILLVLAGFLLFASFPVTVVLA 307

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1244976209 163 ARSssMAPSSAIAAVLTIGFLGTL--IGPPLIGFLSEAFGLRYAFGACVVLAIGIIL 217
Cdd:cd17478   308 QEL--LPGNVGLASGLMMGLSFGLggIGAPVLGALADAFGLESVLLILALLPLLGAL 362
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 12-213 3.88e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 43.69  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  12 FGVISVIAFLAALACWRFLHD-----QPGAERVGRAFTMPDRRLFNYGLIVFFSMACegiMYDWS--VVYFQDVVSAERQ 84
Cdd:cd17370   159 FLLAAIPALLALLILLFVVKEyprppKLRKKSKKTSLKKLPKAFWLYLLAVALFALG---NFSFAflILRAQELGLSAAL 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  85 LVGVgFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAAR 164
Cdd:cd17370   236 IPLL-YALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVAD 314

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1244976209 165 SSSM-APSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAI 213
Cdd:cd17370   315 LVPAeLRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLAL 364
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 86-217 4.55e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.69  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  86 VGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAARS 165
Cdd:cd17324    36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1244976209 166 SS-MAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIIL 217
Cdd:cd17324   116 VPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAAL 168
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 14-217 1.73e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  14 VISVIAFLAALACWRFLHDQPGAE--------RVGRAFTMPDRRLFNYGLIVFFSMACEGIMydwsVVYFQDVVSAERQL 85
Cdd:cd17474   156 FLLAALIPVAFLAILFLLPEPKEKaksssatkLRDLKKALRGRGLLTFLVSAFLYFFLYFAF----LTYLPFLLELLYGI 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  86 VGVGFMVFMGAMTVGRLLL-----NRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAG 160
Cdd:cd17474   232 SPIIIGLLFAGWSVLLALGslfvgRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTT 311

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 161 AAARSSSMAPSSAIAAVL-TIGFLGTLIGPPLIGFLSEAFGLRYAF--GACVVLAIGIIL 217
Cdd:cd17474   312 LVTELAPEEERGTASSLYnFVRFLGQAVGPLLFGLLLEIFGLSAPFlvGAAIALAAAVLL 371
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
86-217 1.90e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.79  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  86 VGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTViplVAGAAARS 165
Cdd:COG2223    42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS---FAVGIALV 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1244976209 166 SSMAPSS----AIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIIL 217
Cdd:COG2223   119 SKWFPPDrrglALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAV 174
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 49-230 1.99e-04

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 41.63  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  49 RLFNYGLIVFFSMACEGIMYDWSVVY--FQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALI 126
Cdd:cd17314     1 RWFVLYVSFLLSAMSTGFILSWSLFYqpWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 127 G-MVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAF 205
Cdd:cd17314    81 GyTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160

                         170       180
                  ....*....|....*....|....*
gi 1244976209 206 GACVVLAIGIILRAGKIPWQAPSVV 230
Cdd:cd17314   161 TILGILAAIVLSVVSLLGFKEPPDN 185
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 12-217 2.49e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.45  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  12 FGVISVIAFLAALACWRFLHDQPGAERVGRAFTMP---------DRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVVSAE 82
Cdd:cd17475   153 FVVAGLVSILAAVLFWLFYREPPAASAATESASTLlrslkevlrNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLS 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  83 RQLVGV-GFMVFMGAMtVGRLLLNRVADRFGT---RSTLQWSGGLALIGMVTTI---AYPSLLASIIGFCLVGLGICTVI 155
Cdd:cd17475   233 VVAAGAlLAVAQLGGA-LGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSllsPGTPLWLLVLLLILLGLFAIGWN 311

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 156 PLvagAAARSSSMAPSSAIAAVL----TIGFLGTLIGPPLIGFLSEAFGLR----YAFGACVVLAIGIIL 217
Cdd:cd17475   312 GL---YLTLVAESAGPEQAGTALglanTINFIGIAIGPPLFGLLVDATHSYapawLALALLLVLAALLLL 378
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-217 2.55e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.26  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  12 FGVISVIAFLAALACWRFLHDQPGAERVGRAF------------TMPDRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVV 79
Cdd:cd06174   155 FLIAAALALLAAILLLLVVPDPPESARAKNEEassksvlkllkrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  80 SAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLAL-IGMVTTIAYPSLLASIIGFCLVGLGICTVIPLV 158
Cdd:cd06174   235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMaLGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1244976209 159 AGAAARS-SSMAPSSAIAAVLTIGFLGTLIGPPLIGFL-SEAFGLRYAFGACVVLAIGIIL 217
Cdd:cd06174   315 FALIAELfPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAI 375
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 85-223 3.52e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  85 LVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAAR 164
Cdd:cd17325    32 QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIAD 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1244976209 165 SSSMAP-SSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLA-IGIILRAGKIP 223
Cdd:cd17325   112 IAPPEErGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAlLALVLALLLLP 172
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 85-217 6.50e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.23  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  85 LVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAAR 164
Cdd:cd17478    32 QAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQ 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1244976209 165 SSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIIL 217
Cdd:cd17478   112 AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVAL 164
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 14-217 7.18e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.87  E-value: 7.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  14 VISVIAFLAALACWRFLhdqpgaervgraftmpdRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVVSAERQLVGVGFMVF 93
Cdd:cd17330   157 VAAALALLNLVLVLFFL-----------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALV 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  94 -MGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAARSSSMAPSS 172
Cdd:cd17330   220 gIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQG 299

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1244976209 173 AIAAVL-TIGFLGTLIGPPLIGFLSEAFGLRYAF-GACVVLAIGIIL 217
Cdd:cd17330   300 KAQGIIqSLQSLARIIGPLLAGPLYSFLGPGVPFlLAAGLLLIALFL 346
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 55-217 8.41e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.90  E-value: 8.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  55 LIVFFSMACEGIMYDWSVVYFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAY 134
Cdd:cd17329     6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 135 PSLLASIIGFCLVGLGICTVIPLVAGAAARSSSMAPSSAIAAVLTIGF-LGTLIGPPLIGFLSEaFGLRYAF--GACVVL 211
Cdd:cd17329    86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAInLGVAIGPLLGGLLLL-YSFRLLFlaAAVLFL 164


                  ....*.
gi 1244976209 212 AIGIIL 217
Cdd:cd17329   165 LAALVL 170
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 72-169 2.19e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.43  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  72 VVYFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSG-GLALIGMVTTIAyPS-----LLASIIGFC 145
Cdd:cd17374    23 IVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLlQLAIFGTCAAFA-PTfpvycVLRFLAGFA 101

                          90       100
                  ....*....|....*....|....
gi 1244976209 146 LVGLGICTVIPLVAGAAARSSSMA 169
Cdd:cd17374   102 VSGISINTLILGTEWTTPRHRALA 125
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 55-217 3.20e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.18  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  55 LIVFFSMACEGIMYDWSVVYFQDVVSAERQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAY 134
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209 135 PSLLASIIGFCLVGLGICTVIPLVAGAAARSSSMAPSSAIAAVLTIGF-LGTLIGPPLIGFLSEA--FGLRYAFGACVVL 211
Cdd:cd06174    82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGsVGGILGPLLGGILASSlgFGWRAVFLIAAAL 161


                  ....*.
gi 1244976209 212 AIGIIL 217
Cdd:cd06174   162 ALLAAI 167
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 90-223 3.22e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 37.87  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  90 FMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLVAGAAARSSSMA 169
Cdd:COG0477    55 VSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPAR 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1244976209 170 PSSAIAAVLTIGF-LGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIILRAGKIP 223
Cdd:COG0477   135 ERGRALGLWGAAIgLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLP 189
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 17-219 4.80e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 37.55  E-value: 4.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  17 VIAFLAALACWRFLHD------QPGAERVGRAFTMPDRRLFNYGLIVFFSMACEGIMYDWSVVYFQDVVSAERQLVGVGF 90
Cdd:cd17473   160 LLALPVLILVLLFLPEparkskSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLAL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  91 MVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLGICTVIPLV-AGAAARSSSMA 169
Cdd:cd17473   240 AIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLnSWAMSLVPPEL 319

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1244976209 170 PSSAIAAVLTIGFLGTLIGPPLIGFLSEAFG-----LRYAFGACVVLAIGIILRA 219
Cdd:cd17473   320 RGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGglsgaFLILGVLALVLAIVLLLLR 374
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 83-228 9.74e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 36.48  E-value: 9.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244976209  83 RQLVGVGFMVFMGAMTVGRLLLNRVADRFGTRSTLQWSGGLALIGMVTTIAYPSLLASIIGFCLVGLG--ICTVIPLVAG 160
Cdd:cd17355    37 RAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGgaGTLAAVAFAT 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1244976209 161 AAARSSSMAPSSAIAAVLTIGFLGTLIGPPLIGFLSEAFGLRYAFGACVVLAIGIILRAGKIPWQAPS 228
Cdd:cd17355   117 VAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPA 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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