NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1250903190|gb|PCZ96573|]
View 

DUF4115 domain-containing protein [Listeria monocytogenes]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11444431)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-69 4.29e-28

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 103.35  E-value: 4.29e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1250903190   1 MTELGDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVMPGKFYARAFIKQYAEAVGLDSATLF 69
Cdd:COG1426     3 LETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
DUF4115 pfam13464
Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of ...
 224-289 1.40e-10

Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.


:

Pssm-ID: 433229 [Multi-domain]  Cd Length: 67  Bit Score: 56.42  E-value: 1.40e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1250903190 224 SLSATGDSWIGVSDANGSTIQNETLstqNPSAEIDLGDNKTVSIVIGNSPVTTVKINGKQLELAPD 289
Cdd:pfam13464   1 VLTFTGDSWVEVRDADGKVLFEGLL---KAGETRTVTGKPPLTLVLGNAGAVEVSVNGKPVDLLGY 63
PTZ00372 super family cl30509
endonuclease 4-like protein; Provisional
 126-220 3.04e-04

endonuclease 4-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00372:

Pssm-ID: 240388  Cd Length: 413  Bit Score: 42.01  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190 126 FIVFILFIVWFFLLNKQDNSTEKVKTD--------TNNTTVKVEDSTKSKDTSKDTEKKDTTTNEDKS-----TETKDKK 192
Cdd:PTZ00372    1 FSLILCMILSFFSGTTQKSKLQPISYIysnvlvlsKEILSTFSEEENKVATTSTKKDKKEDKNNESKKksekkKKKKKEK 80

                          90       100
                  ....*....|....*....|....*...
gi 1250903190 193 EDTAKEVEVTKGETSGNATTYTVKNTDK 220
Cdd:PTZ00372   81 KEPKSEGETKLGFKTPKKSKKTKKKPPK 108
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-69 4.29e-28

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 103.35  E-value: 4.29e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1250903190   1 MTELGDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVMPGKFYARAFIKQYAEAVGLDSATLF 69
Cdd:COG1426     3 LETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 8-68 8.51e-24

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 91.79  E-value: 8.51e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1250903190   8 LKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVMPGKFYARAFIKQYAEAVGLDSATL 68
Cdd:pfam13413   2 LRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARGFLRSYARALGLDPEEL 62
DUF4115 pfam13464
Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of ...
 224-289 1.40e-10

Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.


Pssm-ID: 433229 [Multi-domain]  Cd Length: 67  Bit Score: 56.42  E-value: 1.40e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1250903190 224 SLSATGDSWIGVSDANGSTIQNETLstqNPSAEIDLGDNKTVSIVIGNSPVTTVKINGKQLELAPD 289
Cdd:pfam13464   1 VLTFTGDSWVEVRDADGKVLFEGLL---KAGETRTVTGKPPLTLVLGNAGAVEVSVNGKPVDLLGY 63
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-64 2.93e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 38.30  E-value: 2.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190   5 GDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVMPGKfyarafIKQYAEAVGLD 64
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLET------LEKLAKALGVS 54
PTZ00372 PTZ00372
endonuclease 4-like protein; Provisional
 126-220 3.04e-04

endonuclease 4-like protein; Provisional


Pssm-ID: 240388  Cd Length: 413  Bit Score: 42.01  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190 126 FIVFILFIVWFFLLNKQDNSTEKVKTD--------TNNTTVKVEDSTKSKDTSKDTEKKDTTTNEDKS-----TETKDKK 192
Cdd:PTZ00372    1 FSLILCMILSFFSGTTQKSKLQPISYIysnvlvlsKEILSTFSEEENKVATTSTKKDKKEDKNNESKKksekkKKKKKEK 80

                          90       100
                  ....*....|....*....|....*...
gi 1250903190 193 EDTAKEVEVTKGETSGNATTYTVKNTDK 220
Cdd:PTZ00372   81 KEPKSEGETKLGFKTPKKSKKTKKKPPK 108
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
7-64 4.88e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 37.50  E-value: 4.88e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1250903190    7 KLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVmpgkfyARAFIKQYAEAVGLD 64
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKP------SLETLKKLAKALGVS 52
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
77-309 1.08e-03

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 40.55  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190  77 PETPQQEVVNNEPTRVQSKRNPMPAQSVGNQANTRNRFFDILPKILIALFIVFILFIVWFFLLNkqdNSTEKVKT-DTNN 155
Cdd:NF033483  296 PAPAPTAAEPPEDPDDDGEGGEPADDPEKKKKKKRKKKLWLLVIILALLLVLGVGLGFWAFGGF---GSGKEVTVpDVVG 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190 156 TTV-----KVEDS----TKSKDTSKDTEKKDTTTNEDKSTETKDKKEDTAKeVEVTKGETSGNATTYTVKNTDKMTLSLS 226
Cdd:NF033483  373 KTEaeakeALEKAglkvGKVEEEYSDDVEEGKVISTDPEAGTRVKEGSTVT-LVVSKGPEKVKVPDLTGKSLDEAKKALE 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190 227 ATGDSWIGVSDANGSTIQNETLSTQNPSA--EIDLGDnkTVSIVI--GNSPVTTVKINGKQLELAPDLVKQV-LTINLEA 301
Cdd:NF033483  452 DAGLKVGTIEEEYSDDVPKGTVISQDPAAgtEVDKGT--TVTLTVskGPEPVTVPDVTGMSEEEAKSALESAgLKVGVEE 529


                  ....*...
gi 1250903190 302 SDSSSDAE 309
Cdd:NF033483  530 EEVSSDVP 537
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 2-81 4.75e-03

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 38.01  E-value: 4.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190   2 TELGDKLKQARREKGLSLDDLQQITKIQKRYLVAIE--EGNYAVMpgkfyaraFIKQYAEAVGLDSATLFDEFESEVPET 79
Cdd:PRK08154   27 AALGERVRTLRARRGMSRKVLAQASGVSERYLAQLEsgQGNVSIL--------LLRRVARALGCSLADLLGDVDTSSPDW 98


                  ..
gi 1250903190  80 PQ 81
Cdd:PRK08154   99 LL 100
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-69 4.29e-28

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 103.35  E-value: 4.29e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1250903190   1 MTELGDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVMPGKFYARAFIKQYAEAVGLDSATLF 69
Cdd:COG1426     3 LETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 8-68 8.51e-24

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 91.79  E-value: 8.51e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1250903190   8 LKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVMPGKFYARAFIKQYAEAVGLDSATL 68
Cdd:pfam13413   2 LRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARGFLRSYARALGLDPEEL 62
DUF4115 pfam13464
Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of ...
 224-289 1.40e-10

Domain of unknown function (DUF4115); This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.


Pssm-ID: 433229 [Multi-domain]  Cd Length: 67  Bit Score: 56.42  E-value: 1.40e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1250903190 224 SLSATGDSWIGVSDANGSTIQNETLstqNPSAEIDLGDNKTVSIVIGNSPVTTVKINGKQLELAPD 289
Cdd:pfam13464   1 VLTFTGDSWVEVRDADGKVLFEGLL---KAGETRTVTGKPPLTLVLGNAGAVEVSVNGKPVDLLGY 63
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 5-69 1.27e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 50.75  E-value: 1.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1250903190   5 GDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVMPGKFYarafikQYAEAVGLDSATLF 69
Cdd:pfam12844   1 GERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLY------KIAELLGVPANWLL 59
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-83 9.20e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 48.84  E-value: 9.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190   1 MTELGDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNyaVMPGkfyaRAFIKQYAEAVGLDSATLFDEFESEVPETP 80
Cdd:COG1396     5 KKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGR--RNPS----LETLLKLAKALGVSLDELLGGADEELPEAL 78


                  ...
gi 1250903190  81 QQE 83
Cdd:COG1396    79 LSE 81
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-64 2.93e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 38.30  E-value: 2.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190   5 GDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVMPGKfyarafIKQYAEAVGLD 64
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLET------LEKLAKALGVS 54
PTZ00372 PTZ00372
endonuclease 4-like protein; Provisional
 126-220 3.04e-04

endonuclease 4-like protein; Provisional


Pssm-ID: 240388  Cd Length: 413  Bit Score: 42.01  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190 126 FIVFILFIVWFFLLNKQDNSTEKVKTD--------TNNTTVKVEDSTKSKDTSKDTEKKDTTTNEDKS-----TETKDKK 192
Cdd:PTZ00372    1 FSLILCMILSFFSGTTQKSKLQPISYIysnvlvlsKEILSTFSEEENKVATTSTKKDKKEDKNNESKKksekkKKKKKEK 80

                          90       100
                  ....*....|....*....|....*...
gi 1250903190 193 EDTAKEVEVTKGETSGNATTYTVKNTDK 220
Cdd:PTZ00372   81 KEPKSEGETKLGFKTPKKSKKTKKKPPK 108
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
7-64 4.88e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 37.50  E-value: 4.88e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1250903190    7 KLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNYAVmpgkfyARAFIKQYAEAVGLD 64
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKP------SLETLKKLAKALGVS 52
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
77-309 1.08e-03

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 40.55  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190  77 PETPQQEVVNNEPTRVQSKRNPMPAQSVGNQANTRNRFFDILPKILIALFIVFILFIVWFFLLNkqdNSTEKVKT-DTNN 155
Cdd:NF033483  296 PAPAPTAAEPPEDPDDDGEGGEPADDPEKKKKKKRKKKLWLLVIILALLLVLGVGLGFWAFGGF---GSGKEVTVpDVVG 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190 156 TTV-----KVEDS----TKSKDTSKDTEKKDTTTNEDKSTETKDKKEDTAKeVEVTKGETSGNATTYTVKNTDKMTLSLS 226
Cdd:NF033483  373 KTEaeakeALEKAglkvGKVEEEYSDDVEEGKVISTDPEAGTRVKEGSTVT-LVVSKGPEKVKVPDLTGKSLDEAKKALE 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190 227 ATGDSWIGVSDANGSTIQNETLSTQNPSA--EIDLGDnkTVSIVI--GNSPVTTVKINGKQLELAPDLVKQV-LTINLEA 301
Cdd:NF033483  452 DAGLKVGTIEEEYSDDVPKGTVISQDPAAgtEVDKGT--TVTLTVskGPEPVTVPDVTGMSEEEAKSALESAgLKVGVEE 529


                  ....*...
gi 1250903190 302 SDSSSDAE 309
Cdd:NF033483  530 EEVSSDVP 537
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
157-272 1.95e-03

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 39.68  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190 157 TVKVEDSTKSKDTSKDTEKKDTTTNED--------KSTETKDKKEDTAKEVEVTKGETSGNATTYTVKNTDKMTLSLS-A 227
Cdd:PRK06347   55 TAPADEASKSAEANTTKEAPATATPENtteptvepKQTETKEQTKTPEEKQPAAKQVEKAPAEPATVSNPDNATSSSTpA 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1250903190 228 TGDSWIGVSDANGSTIQNETLSTQNPSAEIDLGDNKTVSIVIGNS 272
Cdd:PRK06347  135 TYNLLQKSALRSGATVQSFIQTIQASSSQIAAENDLYASVMIAQA 179
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-41 2.38e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 35.98  E-value: 2.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1250903190   1 MTELGDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEGNY 41
Cdd:COG1476     2 KKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKY 42
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 2-81 4.75e-03

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 38.01  E-value: 4.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1250903190   2 TELGDKLKQARREKGLSLDDLQQITKIQKRYLVAIE--EGNYAVMpgkfyaraFIKQYAEAVGLDSATLFDEFESEVPET 79
Cdd:PRK08154   27 AALGERVRTLRARRGMSRKVLAQASGVSERYLAQLEsgQGNVSIL--------LLRRVARALGCSLADLLGDVDTSSPDW 98


                  ..
gi 1250903190  80 PQ 81
Cdd:PRK08154   99 LL 100
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 2-39 5.84e-03

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 34.91  E-value: 5.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1250903190   2 TELGDKLKQARREKGLSLDDLQQITKIQKRYLVAIEEG 39
Cdd:COG1813    11 EDYGERIREAREARGLSQEELAEKLGVSESTIRRIERG 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH