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Conserved domains on  [gi|1253729107|gb|PDP29318|]
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lipoprotein [Bacillus anthracis]

Protein Classification

YusW family protein( domain architecture ID 10623936)

YusW family protein similar to Bacillus subtilis protein YusW

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YusW pfam14039
YusW-like protein; The YusW-like protein family includes the B. subtilis YusW protein, which ...
 51-144 1.25e-24

YusW-like protein; The YusW-like protein family includes the B. subtilis YusW protein, which is functionally uncharacterized. This family of proteins is found in bacteria, and is approximately 90 amino acids in length.


:

Pssm-ID: 433665  Cd Length: 91  Bit Score: 90.75  E-value: 1.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253729107  51 NEFSLDADYQDtKKDYEADYKNVAAdkKMEAKIEDHKADVNLTGDEAITKLSPLLQELKFDKGTPDQEVIDQVLNVFKLD 130
Cdd:pfam14039   1 NAFDLDVEYGD-NDEYEVEYELEKN--ETEAKIEDGLNGVKLEGEEALEELEDLLSELSFDSDTSEDEVIDQVLAAFNLD 77

                          90
                  ....*....|....
gi 1253729107 131 KDYQKFELEVVFSD 144
Cdd:pfam14039  78 EDYDEFELEVKFED 91
 
Name Accession Description Interval E-value
YusW pfam14039
YusW-like protein; The YusW-like protein family includes the B. subtilis YusW protein, which ...
 51-144 1.25e-24

YusW-like protein; The YusW-like protein family includes the B. subtilis YusW protein, which is functionally uncharacterized. This family of proteins is found in bacteria, and is approximately 90 amino acids in length.


Pssm-ID: 433665  Cd Length: 91  Bit Score: 90.75  E-value: 1.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253729107  51 NEFSLDADYQDtKKDYEADYKNVAAdkKMEAKIEDHKADVNLTGDEAITKLSPLLQELKFDKGTPDQEVIDQVLNVFKLD 130
Cdd:pfam14039   1 NAFDLDVEYGD-NDEYEVEYELEKN--ETEAKIEDGLNGVKLEGEEALEELEDLLSELSFDSDTSEDEVIDQVLAAFNLD 77

                          90
                  ....*....|....
gi 1253729107 131 KDYQKFELEVVFSD 144
Cdd:pfam14039  78 EDYDEFELEVKFED 91
RA_RASSF6 cd17223
Ras-associating (RA) domain found in Ras-association domain-containing protein 6 (RASSF6); ...
 117-151 3.63e-03

Ras-associating (RA) domain found in Ras-association domain-containing protein 6 (RASSF6); RASSF6 is a member of a family of six related classical RASSF1-6 proteins and is expressed as four transcripts via alternative splicing. All transcripts variant of RASSF6 contain the RA and SARAH domains. The RA domain of the classical RASSF protein family has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin. RA domains mediate interactions with Ras and other small GTPases, SARAH domains mediate protein-protein interactions crucial in the pathways that induce cell cycle arrest and apoptosis. RASSF6 is ubiquitiated and degraded by interacting with MDM2 to stabilize P53 and regulates apoptosis and cell cycle. RASSF6 is a tumor suppressor protein and is epigenetically silenced in childhood leukemia and neuroblastomas. Overexpression of RASSF6 causes apoptosis in HeLa cells.


Pssm-ID: 340743  Cd Length: 87  Bit Score: 34.82  E-value: 3.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1253729107 117 QEVIDQVLNVFKLDKDYQKFELEVVFSDGTKKEYK 151
Cdd:cd17223    26 QEVIKQLLQKFKIENSPNEFALYIIHATGEKKRLK 60
 
Name Accession Description Interval E-value
YusW pfam14039
YusW-like protein; The YusW-like protein family includes the B. subtilis YusW protein, which ...
 51-144 1.25e-24

YusW-like protein; The YusW-like protein family includes the B. subtilis YusW protein, which is functionally uncharacterized. This family of proteins is found in bacteria, and is approximately 90 amino acids in length.


Pssm-ID: 433665  Cd Length: 91  Bit Score: 90.75  E-value: 1.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253729107  51 NEFSLDADYQDtKKDYEADYKNVAAdkKMEAKIEDHKADVNLTGDEAITKLSPLLQELKFDKGTPDQEVIDQVLNVFKLD 130
Cdd:pfam14039   1 NAFDLDVEYGD-NDEYEVEYELEKN--ETEAKIEDGLNGVKLEGEEALEELEDLLSELSFDSDTSEDEVIDQVLAAFNLD 77

                          90
                  ....*....|....
gi 1253729107 131 KDYQKFELEVVFSD 144
Cdd:pfam14039  78 EDYDEFELEVKFED 91
RA_RASSF6 cd17223
Ras-associating (RA) domain found in Ras-association domain-containing protein 6 (RASSF6); ...
 117-151 3.63e-03

Ras-associating (RA) domain found in Ras-association domain-containing protein 6 (RASSF6); RASSF6 is a member of a family of six related classical RASSF1-6 proteins and is expressed as four transcripts via alternative splicing. All transcripts variant of RASSF6 contain the RA and SARAH domains. The RA domain of the classical RASSF protein family has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin. RA domains mediate interactions with Ras and other small GTPases, SARAH domains mediate protein-protein interactions crucial in the pathways that induce cell cycle arrest and apoptosis. RASSF6 is ubiquitiated and degraded by interacting with MDM2 to stabilize P53 and regulates apoptosis and cell cycle. RASSF6 is a tumor suppressor protein and is epigenetically silenced in childhood leukemia and neuroblastomas. Overexpression of RASSF6 causes apoptosis in HeLa cells.


Pssm-ID: 340743  Cd Length: 87  Bit Score: 34.82  E-value: 3.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1253729107 117 QEVIDQVLNVFKLDKDYQKFELEVVFSDGTKKEYK 151
Cdd:cd17223    26 QEVIKQLLQKFKIENSPNEFALYIIHATGEKKRLK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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