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Conserved domains on  [gi|1258770626|gb|PEK90973|]
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bacillithiol biosynthesis deacetylase BshB2 [Bacillus mycoides]

Protein Classification

PIG-L family deacetylase( domain architecture ID 2293)

PIG-L (phosphatidylinositol glycan class L) family deacetylase catalyzes the removal of an acetyl group from a specific acetylated substrate

CATH:  3.40.50.10320
EC:  3.5.1.-
Gene Ontology:  GO:0010125|GO:0046872
PubMed:  24970229
SCOP:  4001164

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PIG-L super family cl00929
GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an ...
3-219 6.59e-125

GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.


The actual alignment was detected with superfamily member TIGR04000:

Pssm-ID: 445182  Cd Length: 217  Bit Score: 352.11  E-value: 6.59e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   3 RHVLVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQMGRNMGKNVFANRETIPNIREKELKDACEAMGIQDLRMLG 82
Cdd:TIGR04000   1 RHVLVIFPHPDDEAFGVAGTIALYRQKGIPVTYACLTLGEMGRNMGNPPFATRESLPEIRKKELIEACKAMGITDLRMLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626  83 FHDKTLEFEDVDFVADKIEAIIQEVNPSRIITFYPEHGVHPDHDAFGRAVVRAVSRMPKEERPAIHAVAITRNREAVLGE 162
Cdd:TIGR04000  81 LRDKTIEFEDDEELADMVKGIIEELNPSLIITFYPGYAVHPDHDATGRAVIRAVRRMPKSERPTVHAVAFSNDAEEELGE 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1258770626 163 PDVVNNISEVFEHKLAALGAHRSQTEAMLEETHAKIKNKDAATLKWLQLEQFWTYKW 219
Cdd:TIGR04000 161 PDIVTDVSEVAETKLAAIRAHRSQTAGMLKELEKKDDDGEPEALEWLGVERFYTYQF 217
 
Name Accession Description Interval E-value
thiol_BshB2 TIGR04000
bacillithiol biosynthesis deacetylase BshB2; Members of this protein family are BshB2 (YojG), ...
3-219 6.59e-125

bacillithiol biosynthesis deacetylase BshB2; Members of this protein family are BshB2 (YojG), an enzyme of bacillithiol biosynthesis; either BshB1 (YpjG) or BshB2 must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 188515  Cd Length: 217  Bit Score: 352.11  E-value: 6.59e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   3 RHVLVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQMGRNMGKNVFANRETIPNIREKELKDACEAMGIQDLRMLG 82
Cdd:TIGR04000   1 RHVLVIFPHPDDEAFGVAGTIALYRQKGIPVTYACLTLGEMGRNMGNPPFATRESLPEIRKKELIEACKAMGITDLRMLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626  83 FHDKTLEFEDVDFVADKIEAIIQEVNPSRIITFYPEHGVHPDHDAFGRAVVRAVSRMPKEERPAIHAVAITRNREAVLGE 162
Cdd:TIGR04000  81 LRDKTIEFEDDEELADMVKGIIEELNPSLIITFYPGYAVHPDHDATGRAVIRAVRRMPKSERPTVHAVAFSNDAEEELGE 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1258770626 163 PDVVNNISEVFEHKLAALGAHRSQTEAMLEETHAKIKNKDAATLKWLQLEQFWTYKW 219
Cdd:TIGR04000 161 PDIVTDVSEVAETKLAAIRAHRSQTAGMLKELEKKDDDGEPEALEWLGVERFYTYQF 217
LmbE COG2120
N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];
4-191 6.90e-55

N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];


Pssm-ID: 441723 [Multi-domain]  Cd Length: 201  Bit Score: 173.96  E-value: 6.90e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   4 HVLVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQMGRNMGknvFANRETIPNIREKELKDACEAMGIQDLRMLGF 83
Cdd:COG2120     1 RVLVVAAHPDDEELGCGGTIARLAAAGHEVTVVTLTDGEAGSPGG---PPLREELAEIRRAEARAAAAILGVSDVEFLGY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626  84 HDKTLEFEDVDfVADKIEAIIQEVNPSRIITFYPeHGVHPDHDAFGRAVVRAVSRM--PKEERPAIHAVAITRNreavlG 161
Cdd:COG2120    78 PDGGLEGPLEE-LRRALARLIREVRPDVVLTPDP-GDGHPDHRAVGRAVLAAARLAglPKILGPRLYLYEVPSD-----T 150
                         170       180       190
                  ....*....|....*....|....*....|
gi 1258770626 162 EPDVVNNISEVFEHKLAALGAHRSQTEAML 191
Cdd:COG2120   151 EPDVAVDITDVLERKLAALAAHASQLDPLF 180
PIG-L pfam02585
GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an ...
6-135 4.78e-37

GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.


Pssm-ID: 426852  Cd Length: 128  Bit Score: 125.87  E-value: 4.78e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   6 LVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQMGRNMGKnvFANRETIPNIREKELKDACEAMGIQDLRMLGFHD 85
Cdd:pfam02585   1 LVVSAHPDDEELGAGGTIARLAAAGVEVHVVCLTDGEAGSGGGS--LEEGEELGEIRRAEARAAAEILGVDDVEFLDYPD 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1258770626  86 KTLEFEDVDFVADKIEAIIQEVNPSRIITFYPEHGVHPDHDAFGRAVVRA 135
Cdd:pfam02585  79 GGLEYWDLEELLDALADLIRRYRPDVVVTPDPDGGGHPDHRATGRAVLAA 128
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
5-145 2.82e-03

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 38.09  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   5 VLVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQ-----------------------MGRNMGKNVFAN-RETIPN 60
Cdd:PRK02122  372 VIIFSPHPDDDVISMGGTFRRLVEQGHDVHVAYQTSGNiavfdeevlrfadfindfnqifgISSDELKKKYEEiIEFLKN 451
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626  61 -----------------IREKELKDACEAMGIQDLRM----LGFHD------KTLEFEDVDFVADkieaIIQEVNPSRII 113
Cdd:PRK02122  452 kkpgeidspevrklkglIRRGEARAACRYVGLPDEHVhfldLPFYEtgtvrkNPIGEADVEIVMD----LLEEIKPHQIF 527
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1258770626 114 T---FYPEHGVHpdhdafgR----AVVRAVSRMPKEERP 145
Cdd:PRK02122  528 VagdLADPHGTH-------RvcldAIFAALDRLKEEEWM 559
 
Name Accession Description Interval E-value
thiol_BshB2 TIGR04000
bacillithiol biosynthesis deacetylase BshB2; Members of this protein family are BshB2 (YojG), ...
3-219 6.59e-125

bacillithiol biosynthesis deacetylase BshB2; Members of this protein family are BshB2 (YojG), an enzyme of bacillithiol biosynthesis; either BshB1 (YpjG) or BshB2 must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 188515  Cd Length: 217  Bit Score: 352.11  E-value: 6.59e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   3 RHVLVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQMGRNMGKNVFANRETIPNIREKELKDACEAMGIQDLRMLG 82
Cdd:TIGR04000   1 RHVLVIFPHPDDEAFGVAGTIALYRQKGIPVTYACLTLGEMGRNMGNPPFATRESLPEIRKKELIEACKAMGITDLRMLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626  83 FHDKTLEFEDVDFVADKIEAIIQEVNPSRIITFYPEHGVHPDHDAFGRAVVRAVSRMPKEERPAIHAVAITRNREAVLGE 162
Cdd:TIGR04000  81 LRDKTIEFEDDEELADMVKGIIEELNPSLIITFYPGYAVHPDHDATGRAVIRAVRRMPKSERPTVHAVAFSNDAEEELGE 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1258770626 163 PDVVNNISEVFEHKLAALGAHRSQTEAMLEETHAKIKNKDAATLKWLQLEQFWTYKW 219
Cdd:TIGR04000 161 PDIVTDVSEVAETKLAAIRAHRSQTAGMLKELEKKDDDGEPEALEWLGVERFYTYQF 217
LmbE COG2120
N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];
4-191 6.90e-55

N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism];


Pssm-ID: 441723 [Multi-domain]  Cd Length: 201  Bit Score: 173.96  E-value: 6.90e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   4 HVLVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQMGRNMGknvFANRETIPNIREKELKDACEAMGIQDLRMLGF 83
Cdd:COG2120     1 RVLVVAAHPDDEELGCGGTIARLAAAGHEVTVVTLTDGEAGSPGG---PPLREELAEIRRAEARAAAAILGVSDVEFLGY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626  84 HDKTLEFEDVDfVADKIEAIIQEVNPSRIITFYPeHGVHPDHDAFGRAVVRAVSRM--PKEERPAIHAVAITRNreavlG 161
Cdd:COG2120    78 PDGGLEGPLEE-LRRALARLIREVRPDVVLTPDP-GDGHPDHRAVGRAVLAAARLAglPKILGPRLYLYEVPSD-----T 150
                         170       180       190
                  ....*....|....*....|....*....|
gi 1258770626 162 EPDVVNNISEVFEHKLAALGAHRSQTEAML 191
Cdd:COG2120   151 EPDVAVDITDVLERKLAALAAHASQLDPLF 180
PIG-L pfam02585
GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an ...
6-135 4.78e-37

GlcNAc-PI de-N-acetylase; Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.


Pssm-ID: 426852  Cd Length: 128  Bit Score: 125.87  E-value: 4.78e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   6 LVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQMGRNMGKnvFANRETIPNIREKELKDACEAMGIQDLRMLGFHD 85
Cdd:pfam02585   1 LVVSAHPDDEELGAGGTIARLAAAGVEVHVVCLTDGEAGSGGGS--LEEGEELGEIRRAEARAAAEILGVDDVEFLDYPD 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1258770626  86 KTLEFEDVDFVADKIEAIIQEVNPSRIITFYPEHGVHPDHDAFGRAVVRA 135
Cdd:pfam02585  79 GGLEYWDLEELLDALADLIRRYRPDVVVTPDPDGGGHPDHRATGRAVLAA 128
thiol_BshB1 TIGR04001
bacillithiol biosynthesis deacetylase BshB1; Members of this protein family are BshB1 (YpjG), ...
4-186 3.18e-19

bacillithiol biosynthesis deacetylase BshB1; Members of this protein family are BshB1 (YpjG), an enzyme of bacillithiol biosynthesis; either BshB1 or BshB2 (YojG) must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 274915  Cd Length: 226  Bit Score: 82.30  E-value: 3.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   4 HVLVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQMGRNmgknvfanreTIPNIREKELKDACEAMGIQDLRMLGF 83
Cdd:TIGR04001   3 DILAFGAHPDDVELGCGGTIAKYVQQGYKVGICDLTRGELSSN----------GTVESRQEEAAAAAEILGVSARINLGL 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626  84 HDKTLEFEDVDfvADKIEAIIQEVNPSRIITFYPEHGvHPDHDAFGRAVVRAV------SRMPKEERPAIHAVAITRNRE 157
Cdd:TIGR04001  73 PDRGLNPTEEN--IREVVEVIRRYRPKLVFAPYPEDR-HPDHGKAARLVTEACfyaglrKYETETPQEPHRPRHVYYYMQ 149
                         170       180
                  ....*....|....*....|....*....
gi 1258770626 158 AVLGEPDVVNNISEVFEHKLAALGAHRSQ 186
Cdd:TIGR04001 150 NGFHEPDFVVDVSETYEQKRAALLAYKSQ 178
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
5-145 2.82e-03

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 38.09  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626   5 VLVVFPHPDDEAFAAGGTIRLLTDQGVPVTYACGTLGQ-----------------------MGRNMGKNVFAN-RETIPN 60
Cdd:PRK02122  372 VIIFSPHPDDDVISMGGTFRRLVEQGHDVHVAYQTSGNiavfdeevlrfadfindfnqifgISSDELKKKYEEiIEFLKN 451
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1258770626  61 -----------------IREKELKDACEAMGIQDLRM----LGFHD------KTLEFEDVDFVADkieaIIQEVNPSRII 113
Cdd:PRK02122  452 kkpgeidspevrklkglIRRGEARAACRYVGLPDEHVhfldLPFYEtgtvrkNPIGEADVEIVMD----LLEEIKPHQIF 527
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1258770626 114 T---FYPEHGVHpdhdafgR----AVVRAVSRMPKEERP 145
Cdd:PRK02122  528 VagdLADPHGTH-------RvcldAIFAALDRLKEEEWM 559
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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