|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
263-602 |
3.36e-88 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 279.13 E-value: 3.36e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 263 ITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGG 342
Cdd:COG5002 46 LLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 343 LSGSINTLSVNLKDRIDRLNVANTKLQQDIERERQLEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKD---TSYYT 419
Cdd:COG5002 126 LLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDpeeRREYL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 420 DVILEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDA-DPSILVKANRSRIEQV 498
Cdd:COG5002 206 EIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDPLLVLGDPDRLEQV 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 499 VVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLH 578
Cdd:COG5002 286 LTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAH 365
|
330 340
....*....|....*....|....*
gi 1260132260 579 HAEYGVYNTTNS-VVFYFNLQKVKE 602
Cdd:COG5002 366 GGRIWVESEPGKgTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
367-597 |
3.63e-72 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 231.72 E-value: 3.63e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 367 KLQQDIERERQLEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTS---YYTDVILEETENMNRLIVEMLELAKLE 443
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerrELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 444 SGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPS-ILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIE 522
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1260132260 523 AEDTVKVEIENTGNPIPEESLEKIWDRFYRldASRSRHTGGTGLGLSIVKNILDLHHAEYGVYNTTNS-VVFYFNL 597
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYR--GDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTL 234
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
277-581 |
2.37e-68 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 224.79 E-value: 2.37e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 277 NEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKD 356
Cdd:COG0642 5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 357 RIDRLNVANTKLQQDIERERQLEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYTDVILEETENMNRLIVEM 436
Cdd:COG0642 85 LLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLINDL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 437 LELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSIL-VKANRSRIEQVVVNLLSNAIRYTPDGEK 515
Cdd:COG0642 165 LDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPEGGT 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1260132260 516 IQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDasRSRHTGGTGLGLSIVKNILDLHHAE 581
Cdd:COG0642 245 VTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGT 308
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
287-587 |
3.43e-47 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 170.91 E-value: 3.43e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 287 YVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDRLNVANT 366
Cdd:COG5000 11 LLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERRR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 367 KLQ----------------------------------------------------------------------------- 369
Cdd:COG5000 91 YLEtilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtl 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 370 ----------------QDIERERQLEKTR--KEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSY-------YTDVILE 424
Cdd:COG5000 171 lvrasplrddgyvivfDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEdredlerALDTIIR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 425 ETENMNRLIVEMLELAKLEsgtyKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSIL-VKANRSRIEQVVVNLL 503
Cdd:COG5000 251 QVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPeVLADRDQLEQVLINLL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 504 SNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldasrSRHTGGTGLGLSIVKNILDLHHAEYG 583
Cdd:COG5000 327 KNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIE 400
|
....
gi 1260132260 584 VYNT 587
Cdd:COG5000 401 LESR 404
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
283-584 |
3.76e-45 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 166.41 E-value: 3.76e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 283 LKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVT-ADDEIGGLSGSINTLsvnlkdrIDRL 361
Cdd:TIGR01386 162 LRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSrAPAELRELAQSFNAM-------LGRL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 362 NVANTKLQQdiererqlektrkeFISGVSHELKTPLSVIRSFAEGIkdgVSKDTS--YYTDVI---LEETENMNRLIVEM 436
Cdd:TIGR01386 235 EDAFQRLSQ--------------FSADLAHELRTPLTNLLGQTQVA---LSQPRTgeEYREVLesnLEELERLSRMVSDM 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 437 LELAKLESGTYKLDMTTFSIGELTQQV--YTKLLFSMEEKHLQVNIDAdpsiLVKANRSRIEQVVVNLLSNAIRYTPDGE 514
Cdd:TIGR01386 298 LFLARADNGQLALERVRLDLAAELAKVaeYFEPLAEERGVRIRVEGEG----LVRGDPQMFRRAISNLLSNALRHTPDGG 373
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 515 KIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLHHAEYGV 584
Cdd:TIGR01386 374 TITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASA 443
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
180-602 |
1.11e-40 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 154.94 E-value: 1.11e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 180 RLASRYKSTTRIVFTGVITKLQLPSKAEVRLANDIETLQAVQYFADMIREGTSNSNQLSTFILDGGENIKNSIFVKPIIE 259
Cdd:COG4251 83 LLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 260 NGKITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFsekLPVTADDE 339
Cdd:COG4251 163 LLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLL---LLLLVLLL 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 340 IGGLSGSINTLSVNLKDRIDRLNVANTKLQQdieRERQLEKTRKE---FISGVSHELKTPLSVIRSFA----EGIKDGVS 412
Cdd:COG4251 240 LLILLLLLLILVLELLELRLELEELEEELEE---RTAELERSNEEleqFAYVASHDLREPLRKISGFSqlleEDYGDKLD 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 413 KDTSYYTDVILEETENMNRLIVEMLELAKLesGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSilVKANR 492
Cdd:COG4251 317 EEGREYLERIRDAAERMQALIDDLLAYSRV--GRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT--VRGDP 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 493 SRIEQVVVNLLSNAIRYTPDGE--KIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRhtGGTGLGLSI 570
Cdd:COG4251 393 TLLRQVFQNLISNAIKYSRPGEppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAI 470
|
410 420 430
....*....|....*....|....*....|...
gi 1260132260 571 VKNILDLHHAEYGVYNTTNS-VVFYFNLQKVKE 602
Cdd:COG4251 471 VKKIVERHGGRIWVESEPGEgATFYFTLPKAPA 503
|
|
| his_kin_PieS |
NF041210 |
two component system sensor histidine kinase PieS; |
251-589 |
4.35e-39 |
|
two component system sensor histidine kinase PieS;
Pssm-ID: 469114 [Multi-domain] Cd Length: 474 Bit Score: 149.55 E-value: 4.35e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 251 SIFVKPIIENGkitEYAFAIASLQPVNEAMLV---LKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFD 327
Cdd:NF041210 133 SVVYVPILNGD---EFLGSIILNSPISGTEKVigtINQYMFYTILLSITIALILSAILSKLQVNRINKLRKATKRVIRGN 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 328 FSEKLPVTADDEIGGLSGSINTLSVNLKDRidrlnvantklQQDIERErqlEKTRKEFISGVSHELKTPLSVIRSFAEG- 406
Cdd:NF041210 210 YETRLKENNFDEIGALAHDFNKMTETLAES-----------KEEIERQ---EKRRRQFIADVSHEMRTPLTTISGLTEGl 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 407 IKDGVSKD-TSYYTDVILEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPS 485
Cdd:NF041210 276 VNDIIPKSeTDRCIALIDTEAKRLTKLVNENLDYERIRSNKIQLYKTRFGVHAFLDLIKEQLEPLASEKGNQIIVDAPLD 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 486 ILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVkVEIENTGNPIPEESLEKIWDRFYRLDASR-SRHTGGT 564
Cdd:NF041210 356 LEVYADYDRLTQIVINIVKNSIQFTENGTITLTGRQDYKETI-LTITDTGIGMDTGELEQIWERFYKADMSRtSTAFGES 434
|
330 340
....*....|....*....|....*
gi 1260132260 565 GLGLSIVKNILDLHHAEYGVYNTTN 589
Cdd:NF041210 435 GIGLSIVKQLVEYHDGSIEVESEPN 459
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
343-599 |
1.09e-35 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 140.29 E-value: 1.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 343 LSGSI-NTLSVNLKDRIDRLNVANTKLQQDIERERQLEK-----TRK-EFISGVSHELKTPLSVIRSFAEgIKDGVSKDT 415
Cdd:PRK09835 216 VSRQIqNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERiedvfTRQsNFSADIAHEIRTPITNLITQTE-IALSQSRSQ 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 416 SYYTDVI---LEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSiLVKANR 492
Cdd:PRK09835 295 KELEDVLysnLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPC-QVAGDP 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 493 SRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVK 572
Cdd:PRK09835 374 LMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVK 453
|
250 260
....*....|....*....|....*..
gi 1260132260 573 NILDLHHAEYGVYNTTNSVVFYFNLQK 599
Cdd:PRK09835 454 SIVVAHKGTVAVTSDARGTRFVISLPR 480
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
296-578 |
1.58e-35 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 139.38 E-value: 1.58e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 296 LVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLsvnlkdridrlnvANTklqqdIERE 375
Cdd:PRK10549 175 LLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQL-------------AST-----LEKN 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 376 RQLektRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYTDVILEETENMNRLIVEMLELAKLESGTYKLDMTTFS 455
Cdd:PRK10549 237 EQM---RRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVD 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 456 IGELTQQVYTKLLFSMEEKHLQVNIDADPSILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTG 535
Cdd:PRK10549 314 LVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSA 393
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1260132260 536 NPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLH 578
Cdd:PRK10549 394 PGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAH 436
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
371-580 |
1.76e-35 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 138.60 E-value: 1.76e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 371 DIERERQLEKTRKEFISGVSHELKTPLSVIRSFAEGIKD----GVSKDTSYYTdvILEETENMNRLIVEMLELAKLESGT 446
Cdd:PRK11006 193 DVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDqpleGALREKALHT--MREQTQRMEGLVKQLLTLSKIEAAP 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 447 ykldmttfsIGELTQQVYTKLLFSMEEKHLQ--------VNIDADPSILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQV 518
Cdd:PRK11006 271 ---------TIDLNEKVDVPMMLRVLEREAQtlsqgkhtITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITV 341
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1260132260 519 SIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLHHA 580
Cdd:PRK11006 342 RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDS 403
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
369-580 |
3.40e-34 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 133.43 E-value: 3.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 369 QQDIERE-RQLEKTR--KEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSY-YTDVILEETENMNRLIVEMLELAKLES 444
Cdd:COG3852 119 RKRLERElRRAEKLAavGELAAGLAHEIRNPLTGIRGAAQLLERELPDDELReYTQLIIEEADRLNNLVDRLLSFSRPRP 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 445 gtykLDMTTFSIGELTQQVYTklLFSME-EKHLQVNIDADPSI-LVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSI-- 520
Cdd:COG3852 199 ----PEREPVNLHEVLERVLE--LLRAEaPKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTrv 272
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1260132260 521 --------IEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldasrSRHTGGTGLGLSIVKNILDLHHA 580
Cdd:COG3852 273 erqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGG 334
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
257-579 |
3.47e-34 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 133.39 E-value: 3.47e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 257 IIENGKITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTA 336
Cdd:COG4191 8 LLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 337 DDEIGGLSGSINTLSVNLKDRIDRLNVANTKLQQDIER----ERQLEKTRK-----EFISGVSHELKTPLSVIRSFAEGI 407
Cdd:COG4191 88 LLLEALLLLLLAALDAEENAELEELERDITELERAEEElrelQEQLVQSEKlaalgELAAGIAHEINNPLAAILGNAELL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 408 KDGVSK-----DTSYYTDVILEETENMNRLIVEMLELAKLESgtykLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDA 482
Cdd:COG4191 168 RRRLEDepdpeELREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVELDL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 483 DPSI-LVKANRSRIEQVVVNLLSNAIRYTPDGE--KIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldasrsr 559
Cdd:COG4191 244 PPDLpPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF-------- 315
|
330 340
....*....|....*....|....*
gi 1260132260 560 hT-----GGTGLGLSIVKNILDLHH 579
Cdd:COG4191 316 -TtkpvgKGTGLGLSISYGIVEKHG 339
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
391-586 |
8.23e-34 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 134.59 E-value: 8.23e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 391 HELKTPLSVIRSFAEGIKDGVSKDT-SYYTDVILEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLF 469
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDPPPEDrARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 470 SMEEKHLQVNIDADPsILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDR 549
Cdd:PRK11100 345 QAAAKGITLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFER 423
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1260132260 550 FYRLdasrSRHTGG---TGLGLSIVKNILDLHHAEYGVYN 586
Cdd:PRK11100 424 FYSL----PRPANGrksTGLGLAFVREVARLHGGEVTLRN 459
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
354-583 |
1.25e-28 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 117.74 E-value: 1.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 354 LKDRIDRLNVANTKLQQDIERERQLektrkefISGVSHELKTPLS----VIRSFAEGIKDGVSKDTSYYT----DVILEE 425
Cdd:PRK09303 130 LSDELFVLRQENETLLEQLKFKDRV-------LAMLAHDLRTPLTaaslALETLELGQIDEDTELKPALIeqlqDQARRQ 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 426 TENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDAdPSIL--VKANRSRIEQVVVNLL 503
Cdd:PRK09303 203 LEEIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDI-PSDLpsVYADQERIRQVLLNLL 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 504 SNAIRYTPDGEKIQVSIIEAEDT-VKVEIENTGNPIPEESLEKIWDRFYRLdaSRSRHTGGTGLGLSIVKNILDLHhaeY 582
Cdd:PRK09303 282 DNAIKYTPEGGTITLSMLHRTTQkVQVSICDTGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSVCRRIVRVH---Y 356
|
.
gi 1260132260 583 G 583
Cdd:PRK09303 357 G 357
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
490-587 |
3.38e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 108.89 E-value: 3.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 490 ANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDaSRSRHTGGTGLGLS 569
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90
....*....|....*...
gi 1260132260 570 IVKNILDLHHAEYGVYNT 587
Cdd:smart00387 80 IVKKLVELHGGEISVESE 97
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
375-584 |
1.31e-27 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 116.61 E-value: 1.31e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 375 ERQLEKTRK-----EFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYTDVILEETENMNRLIVEMLELAKLESGtykl 449
Cdd:COG5809 258 EELLRKSEKlsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAI---- 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 450 DMTTFSIGELTQQVYTklLFSME--EKHLQVNID-ADPSILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSI-IEAED 525
Cdd:COG5809 334 KYEPKDLNTLIEEVIP--LLQPQalLKNVQIELElEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETkAEDDD 411
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1260132260 526 TVKVEIENTGNPIPEESLEKIWDRFYrldasrSRHTGGTGLGLSIVKNILDLHHAEYGV 584
Cdd:COG5809 412 KVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITV 464
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
352-579 |
3.42e-26 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 113.14 E-value: 3.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 352 VNLKDRIDRLnvantKLQqdiERERQLEK--TRKEFISGVSHELKTPLSVIRSFAEGIKDGVS-KDTSYYTDVILEETEN 428
Cdd:PRK11360 366 VIFSDLTERK-----RLQ---RRVARQERlaALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSdPPSQEYLSVVLREVDR 437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 429 MNRLIVEMLELAKlesgTYKLDMTTFSIGELTQQVytklLFSMEEKHLQVNI----DADPSI-LVKANRSRIEQVVVNLL 503
Cdd:PRK11360 438 LNKVIDQLLEFSR----PRESQWQPVSLNALVEEV----LQLFQTAGVQARVdfetELDNELpPIWADPELLKQVLLNIL 509
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1260132260 504 SNAIRYTPDGEKIQVSI-IEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASrsrhtgGTGLGLSIVKNILDLHH 579
Cdd:PRK11360 510 INAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHG 580
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
264-581 |
5.53e-26 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 109.67 E-value: 5.53e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 264 TEYAFAIASLqpvneamlvlkdyYVYALIIVfLVIILLSFYYSKIIVKPLikiNRVTKKMAN--FDFSEKLPVTAD-DEI 340
Cdd:PRK10755 54 KEIREAVASL-------------LVPSLVMV-SLTLLICFQAVRWITRPL---AELQKELEArtADNLTPIAIHSStLEI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 341 GGLSGSINTLSvnlkdridrlnvanTKLQQDIERERQlektrkeFISGVSHELKTPLSVIRSFAEGI-KDGVSKdtsyyT 419
Cdd:PRK10755 117 EAVTSALNQLV--------------SRLTSTLDQERL-------FTADVAHELRTPLAGIRLHLELLeKQHHID-----V 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 420 DVILEETENMNRLIVEMLELAKLE----SGTYkldmTTFSigeLTQQVYTKLLFSMEE------KHLQVNiDADPSILVK 489
Cdd:PRK10755 171 APLIARLDQMMHTVEQLLQLARAGqsfsSGHY----QTVK---LLEDVILPSQDELSEmleqrqQTLLLP-ESAADITVQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 490 ANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDasrSRHtGGTGLGLS 569
Cdd:PRK10755 243 GDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD---SRY-GGIGLGLS 318
|
330
....*....|..
gi 1260132260 570 IVKNILDLHHAE 581
Cdd:PRK10755 319 IVSRITQLHHGQ 330
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-586 |
1.33e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 98.63 E-value: 1.33e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 485 SILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVsIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDasrSRHTGGT 564
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEI-KLSADDGAVIRVEDNGPGIDEEELEALFERFYRSD---GQNYGGS 79
|
90 100
....*....|....*....|..
gi 1260132260 565 GLGLSIVKNILDLHHAEYGVYN 586
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGN 101
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
349-597 |
2.36e-24 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 108.20 E-value: 2.36e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 349 TLSVNLKDRIDRLNVANTKLQQDIERERqlEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYT---DVILEE 425
Cdd:PRK10490 633 TFTLLIANALERLTLTASEEQARLASER--EQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHArqaSEIRQQ 710
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 426 TENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIdADPSILVKANRSRIEQVVVNLLSN 505
Cdd:PRK10490 711 VLNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSL-PEPLTLIHVDGPLFERVLINLLEN 789
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 506 AIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRldASRSRHTGGTGLGLSIVKNILDLHHAEYGVY 585
Cdd:PRK10490 790 AVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFAR--GNKESAIPGVGLGLAICRAIVEVHGGTIWAE 867
|
250
....*....|...
gi 1260132260 586 NTTN-SVVFYFNL 597
Cdd:PRK10490 868 NRPEgGACFRVTL 880
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
491-579 |
1.55e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 95.61 E-value: 1.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 491 NRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSI 570
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
....*....
gi 1260132260 571 VKNILDLHH 579
Cdd:cd16946 81 CHNIALAHG 89
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
360-574 |
4.31e-23 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 102.37 E-value: 4.31e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 360 RLNVANTKLQQDIErerQLEKTRKEFISGVSHELKTPLSVIRSFAEgIKDGVSKDtsyytdvileETENMNR-------L 432
Cdd:PRK10604 193 RLGVAFNQMADNIN---ALIASKKQLIDGIAHELRTPLVRLRYRLE-MSDNLSAA----------ESQALNRdigqleaL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 433 IVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSILVKANRsRIEQVVVNLLSNAIRYTpd 512
Cdd:PRK10604 259 IEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMR-LMERVLDNLLNNALRYA-- 335
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1260132260 513 GEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNI 574
Cdd:PRK10604 336 HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSI 397
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
490-599 |
5.39e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 93.97 E-value: 5.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 490 ANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIiEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDasrSRHTGGTGLGLS 569
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|...
gi 1260132260 570 IVKNILDLHHAEYGVYNTTN---SVVFYFNLQK 599
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGggtTVTLTLPLAQ 109
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
291-581 |
6.57e-23 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 101.53 E-value: 6.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 291 LIIVFLVIILLSF----YYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKdridrlnvant 366
Cdd:PRK09467 155 LFRYTLAIGLLSVaggwLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIK----------- 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 367 klqqdiererQLEKTRKEFISGVSHELKTPLSVIRSFAEGIkdgvSKDTSYYTDVILEETENMNRLIVEMLELAKLESgt 446
Cdd:PRK09467 224 ----------QLEDDRTLLMAGVSHDLRTPLTRIRLATEMM----SEEDGYLAESINKDIEECNAIIEQFIDYLRTGQ-- 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 447 yKLDMTTFSIGELTQQVytkllfSMEEKHLQVNID---ADPSILVKANRSRIEQVVVNLLSNAIRYTpdGEKIQVSIIEA 523
Cdd:PRK09467 288 -EMPMEMADLNALLGEV------IAAESGYEREIEtalQPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTE 358
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1260132260 524 EDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSrhTGGTGLGLSIVKNILDLHHAE 581
Cdd:PRK09467 359 GKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGK 414
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
498-597 |
8.29e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 93.22 E-value: 8.29e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 498 VVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDasRSRHTGGTGLGLSIVKNILDL 577
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGD--NSRNTEGAGLGLSIAKAIIEL 81
|
90 100
....*....|....*....|
gi 1260132260 578 HHAEYGVYNTTNSVVFYFNL 597
Cdd:cd16923 82 HGGSASAEYDDNHDLFKVRL 101
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
377-579 |
1.18e-22 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 101.16 E-value: 1.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 377 QLEKTRKEFISGVSHELKTPLSVIRsFAEGI---KDGVSKDTSYytdvILEETENMNRLIVEMLELAKLEsgtYKLDMT- 452
Cdd:PRK09470 238 RMMTSQQRLLSDISHELRTPLTRLQ-LATALlrrRQGESKELER----IETEAQRLDSMINDLLVLSRNQ---QKNHLEr 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 453 -TFSIGELTQQVYTKLLFSMEEKHLQVNIDADP-SILVKANRSRIEQVVVNLLSNAIRYTPDgeKIQVSIIEAEDTVKVE 530
Cdd:PRK09470 310 eTFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPgPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTIT 387
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1260132260 531 IENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLHH 579
Cdd:PRK09470 388 VDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHR 436
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
333-580 |
5.73e-22 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 99.42 E-value: 5.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 333 PVTADDEIGGLSGSINTLSVNLKDRIDRLN--VANTKLQQDIERERQLEKT--RKEFIS-------GVSHELKTPLSVIR 401
Cdd:COG5805 227 EFIIEREIITKDGRIRYFEAVIVPLIDTDGsvKGILVILRDITEKKEAEELmaRSEKLSiagqlaaGIAHEIRNPLTSIK 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 402 SFAEGIKDGVSKDTSYYtDVILEETENMNRLIVEMLELAKLESGTYKldmtTFSIGELTQQVYTKLLFSMEEKHLQVNID 481
Cdd:COG5805 307 GFLQLLQPGIEDKEEYF-DIMLSELDRIESIISEFLALAKPQAVNKE----KENINELIQDVVTLLETEAILHNIQIRLE 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 482 A-DPSILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASrsrh 560
Cdd:COG5805 382 LlDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK---- 457
|
250 260
....*....|....*....|
gi 1260132260 561 tgGTGLGLSIVKNILDLHHA 580
Cdd:COG5805 458 --GTGLGLMVSYKIIENHNG 475
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-581 |
3.36e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 88.80 E-value: 3.36e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 501 NLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLHHA 580
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
.
gi 1260132260 581 E 581
Cdd:cd16952 87 R 87
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
277-574 |
3.61e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 98.18 E-value: 3.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 277 NEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLsvnlkd 356
Cdd:PRK15347 289 NEALKPALQQLPFALLILVLLTSVLFLLLRRYLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKAYNQL------ 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 357 rIDRLNVANTKLQQDI-ERERQLEKTRK----------EFISGVSHELKTPLSVIRSFAEGIKDGVSK-------DTSYY 418
Cdd:PRK15347 363 -LDTLNEQYDTLENKVaERTQALAEAKQraeqankrksEHLTTISHEIRTPLNGVLGALELLQNTPLTaeqmdlaDTARQ 441
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 419 -TDVILEetenmnrLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEK--HLQVNIDADPSILVKANRSRI 495
Cdd:PRK15347 442 cTLSLLA-------IINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKslTLRTFVGAHVPLYLHLDSLRL 514
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1260132260 496 EQVVVNLLSNAIRYTPDGEkIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDAsrsrHTGGTGLGLSIVKNI 574
Cdd:PRK15347 515 RQILVNLLGNAVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSL 588
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
290-581 |
8.26e-21 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 96.68 E-value: 8.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 290 ALIIVFLVIILLSFYY-SKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSgsiNTLSVNLKDRIDRLNVANTKL 368
Cdd:COG4192 331 IALLSLLLAVLINYFYvRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIA---RLLRVFRDQAIEKTQELETEI 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 369 QQDIERERQLEKTRKEFI------------SGVSHELKTPLSVIRSFAEGIKDGVSKDT----SYYTDVILEETENMNRL 432
Cdd:COG4192 408 EERKRIEKNLRQTQDELIqaakmavvgqtmTSLAHELNQPLNAMSMYLFSAKKALEQENyaqlPTSLDKIEGLIERMDKI 487
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 433 IVEMLELAKLESGTykldMTTFSIGELTQQVYtkLLFSMEEKHLQVNIDADPSILVKANRSRIEQVVVNLLSNAIRYTPD 512
Cdd:COG4192 488 IKSLRQFSRKSDTP----LQPVDLRQVIEQAW--ELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVAT 561
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1260132260 513 GEKIQVSIIEAEDTVKVEIENTGNPIPeeSLEKIWDRFYrldasrSRHTGGTGLGLSIVKNILDLHHAE 581
Cdd:COG4192 562 QPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGD 622
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
495-578 |
2.88e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 86.39 E-value: 2.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTPDGE-KIQVSIIEAEDT---VKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSI 570
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
....*...
gi 1260132260 571 VKNILDLH 578
Cdd:cd16922 81 SKKLVELM 88
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
494-578 |
2.44e-19 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 83.70 E-value: 2.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 494 RIEQVVVNLLSNAIRYTPDGEKIQVsIIEAEDT--VKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIV 571
Cdd:cd16925 4 KYERVVLNLLSNAFKFTPDGGRIRC-ILEKFRLnrFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIV 82
|
....*..
gi 1260132260 572 KNILDLH 578
Cdd:cd16925 83 KEFVELH 89
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
358-579 |
2.62e-19 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 90.86 E-value: 2.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 358 IDRLNVANTKLQQDIERERQlektrkeFISGVSHELKTPLSVIRSFAEGIKdgVSKDtsyytDVILEETENMN------- 430
Cdd:PRK10337 220 VEALNQLFARTHAMMVRERR-------FTSDAAHELRSPLAALKVQTEVAQ--LSDD-----DPQARKKALLQlhagidr 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 431 --RLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSILVKANRSRIEQVVV-NLLSNAI 507
Cdd:PRK10337 286 atRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVrNLLDNAI 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1260132260 508 RYTPDGEKIQVSIIEAEDTVkveiENTGNPIPEESLEKIWDRFYRldaSRSRHTGGTGLGLSIVKNILDLHH 579
Cdd:PRK10337 366 RYSPQGSVVDVTLNARNFTV----RDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHG 430
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
374-578 |
2.98e-19 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 90.62 E-value: 2.98e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 374 RERQL---EKTRKE-------FISGVSHELKTPLSVIRS----FAEGIKDGvSKDTSYyTDVILEETENMNRLIVEMLEL 439
Cdd:PRK10364 219 RSRQLlqdEMKRKEklvalghLAAGVAHEIRNPLSSIKGlakyFAERAPAG-GEAHQL-AQVMAKEADRLNRVVSELLEL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 440 AKlesgTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSI-LVKANRSRIEQVVVNLLSNAIRYTPDGEKIQV 518
Cdd:PRK10364 297 VK----PTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISV 372
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 519 SIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASrsrhtgGTGLGLSIVKNILDLH 578
Cdd:PRK10364 373 TASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQH 426
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-581 |
8.52e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 81.99 E-value: 8.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTPdgEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNI 574
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
....*..
gi 1260132260 575 LDLHHAE 581
Cdd:cd16949 79 IEQHGGK 85
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
371-577 |
1.45e-18 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 90.00 E-value: 1.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 371 DI-ERER---QLEKTRKE---FISGVSHELKTPLSvirsfaeGIKdGVSKdtsyytdvILEET----ENMNRL------- 432
Cdd:PRK11091 265 DItERKRyqdALEKASRDkttFISTISHELRTPLN-------GIV-GLSR--------ILLDTeltaEQRKYLktihvsa 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 433 ---------IVEM--LELAKLESGTYKLDMTTFsIGELtqQVYTKLLfsMEEKHLQVNIDADPS--ILVKANRSRIEQVV 499
Cdd:PRK11091 329 itlgnifndIIDMdkMERRKLQLDNQPIDFTDF-LADL--ENLSGLQ--AEQKGLRFDLEPLLPlpHKVITDGTRLRQIL 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 500 VNLLSNAIRYTPDGEkIQVSII-EAEDTVKVEIENTGNPIPEESLEKIWDRFYRL-DASRSRHTGGTGLGLSIVKNILDL 577
Cdd:PRK11091 404 WNLISNAVKFTQQGG-VTVRVRyEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQA 482
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
225-579 |
1.80e-18 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 87.98 E-value: 1.80e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 225 DMIREGTSNSNqLSTFILDGGENIKNSIFVKPIIENGKITeyaFAIASLQP-------VNEAMLVLKD-------YYVYA 290
Cdd:NF038389 59 EELEKYLKNFG-FMPITDKKLEKEILEIGKNKFILKENGS---FRILKYNDkiyllikNDGFSLLLEDnekksyrYYYII 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 291 LIIVFLVIILLSFYYSKII-VKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDridrlnvantklq 369
Cdd:NF038389 135 VFFIFLILLLLILYISVLKsLKPLKKLKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKA------------- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 370 qdIERERQLektrkeFISGVSHELKTPLSVIRSFAEGIKDGVSKDtsyytdvILEET-ENMNRLIVEMLELAKLESGTYK 448
Cdd:NF038389 202 --LNESRQL------FLRNIMHELKTPITKGRIVAEMLEDEKQKE-------RLISIfERLESLINEFAKIEQLTSKNYK 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 449 LDMTTFSIGELTQQVyTKLLfsMEEKHLQVNIDADPSILVKANRSRIEQVVVNLLSNAIRYTPDGekiQVSIIEAEDtvK 528
Cdd:NF038389 267 LNKKEYRLSDIIDEA-IDML--MIDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYSPDK---KVTIEIKGD--K 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1260132260 529 VEIENTGNPIPEEsLEKIWDRFYRLDASRSrhtGGTGLGLSIVKNILDLHH 579
Cdd:NF038389 339 IEFKNKGEPLEEP-LEYYFEPFFKGNEKSK---SGFGLGLYIVKNILKAHG 385
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
371-572 |
2.96e-18 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 89.14 E-value: 2.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 371 DIERERQLEKTR--KEFISGVSHELKTPLS-VIrSFA-EGIKDGVSKDTSYYTDVILEETENMNRLIVEMLELAKLESGT 446
Cdd:PRK11107 280 DLAKKRAQEAARikSEFLANMSHELRTPLNgVI-GFTrQTLKTPLTPTQRDYLQTIERSANNLLAIINDILDFSKLEAGK 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 447 YKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSI--LVKANRSRIEQVVVNLLSNAIRYTPDGE-KIQVSIIEA 523
Cdd:PRK11107 359 LVLENIPFSLRETLDEVVTLLAHSAHEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESGNiDILVELRAL 438
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1260132260 524 ED---TVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVK 572
Cdd:PRK11107 439 SNtkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQ 490
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
371-575 |
1.66e-16 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 83.63 E-value: 1.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 371 DIERERQLEKT--RKEFISGVSHELKTPLSVIRSFAEGIK-DGVSKDTSYYTDVILEET-ENMNRLIVEMLELAKLESGT 446
Cdd:PRK09959 699 EVERNKAINATvaKSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATgQSLLGLIGEILDVDKIESGN 778
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 447 YKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDAD--PSILVKANRSRIEQVVVNLLSNAIRYTPDGE-KIQVSIIEA 523
Cdd:PRK09959 779 YQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfpDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHI 858
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1260132260 524 ED---TVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRhtGGTGLGLSIVKNIL 575
Cdd:PRK09959 859 DDnhaVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQ--TGSGLGLMICKELI 911
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-578 |
1.02e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 73.23 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTpdGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNI 574
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
....
gi 1260132260 575 LDLH 578
Cdd:cd16939 79 ALWH 82
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
382-445 |
1.17e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 71.47 E-value: 1.17e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1260132260 382 RKEFISGVSHELKTPLSVIRSFAEGIKDG-VSKDTSYYTDVILEETENMNRLIVEMLELAKLESG 445
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEkLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
491-587 |
1.72e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 72.49 E-value: 1.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 491 NRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRsRHTGGTGLGLSI 570
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90
....*....|....*..
gi 1260132260 571 VKNILDLHHAEYGVYNT 587
Cdd:cd16975 80 AKNLVEKHGGSLIIENS 96
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-586 |
2.50e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 72.11 E-value: 2.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLdaSRSrHTG--GTGLGLSIVK 572
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL--PRP-HSGqkSTGLGLAFVQ 81
|
90
....*....|....
gi 1260132260 573 NILDLHHAEYGVYN 586
Cdd:cd16945 82 EVAQLHGGRITLRN 95
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
296-570 |
3.64e-15 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 79.18 E-value: 3.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 296 LVIILLSFYYsKIIVKPLIKINRVTKKMANFDFSEKLPVTAD----DEIGGL----SGSINTLSVNLKDRIDRLNVANTK 367
Cdd:PRK11466 344 LILILWRVVY-RSVTRPLAEQTQALQRLLDGDIDSPFPETAGvrelDTIGRLmdafRSNVHALNRHREQLAAQVKARTAE 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 368 LQQDIERERQL-------EKTRKEFISGVSHELKTPLSVIRSFAEGIKDG-VSKDTSYYTDVILEETENMNRLIVEMLEL 439
Cdd:PRK11466 423 LQELVIEHRQAraeaekaSQAKSAFLAAMSHEIRTPLYGILGTAQLLADNpALNAQRDDLRAITDSGESLLTILNDILDY 502
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 440 AKLESGTYKLDMTT--FSigelTQQVYTKLLFSMEE--KHLQVNIDAD-----PSILVKANRsRIEQVVVNLLSNAIRYT 510
Cdd:PRK11466 503 SAIEAGGKNVSVSDepFE----PRPLLESTLQLMSGrvKGRPIRLATDiaddlPTALMGDPR-RIRQVITNLLSNALRFT 577
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 511 PDGEkIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRsrhtGGTGLGLSI 570
Cdd:PRK11466 578 DEGS-IVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTI 632
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
382-445 |
7.69e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 69.13 E-value: 7.69e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1260132260 382 RKEFISGVSHELKTPLSVIRSFAEGIKDG-VSKDTSYYTDVILEETENMNRLIVEMLELAKLESG 445
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTeLSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
379-441 |
8.56e-15 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 69.16 E-value: 8.56e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1260132260 379 EKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSY--YTDVILEETENMNRLIVEMLELAK 441
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQreYLERIREEAERLLRLINDLLDLSR 65
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
237-581 |
9.87e-15 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 76.60 E-value: 9.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 237 LSTFILDGGENIKNSIFVKPIIENGKITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKI 316
Cdd:COG2972 109 LALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 317 NRVTKKMANFDFSeKLPVTADDEIGGLSGSINtlsvNLKDRIDRLnvantklqqdIERERQLEKTRKEFisgvshELKT- 395
Cdd:COG2972 189 KKAMKKVEKGDLV-RLEVSGNDEIGILARSFN----EMVERIKEL----------IEEVYELELEKKEA------ELKAl 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 396 -----P------LSVIRSFAEgikdgvskdtsyytdviLEETENMNRLIVEMLEL--AKLESGTyklDMTTFSIgELTqq 462
Cdd:COG2972 248 qaqinPhflfntLNSIRWLAE-----------------LEDPEEAEEMLEALSKLlrYSLSKGD---ELVTLEE-ELE-- 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 463 vYTKLLFSME----EKHLQVNIDADPSILvkanrsriEQVVVNLLS-----NAIRY----TPDGEKIQVSIIEAEDTVKV 529
Cdd:COG2972 305 -LIKSYLEIQklrfGDRLEVEIEIDEELL--------DLLIPKLILqplveNAIEHgiepKEGGGTIRISIRKEGDRLVI 375
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1260132260 530 EIENTGNPIPEESLEKIWDRFyrldasrSRHTGGTGLGLSIVKNILDLHHAE 581
Cdd:COG2972 376 TVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGE 420
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
269-572 |
1.15e-14 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 76.46 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 269 AIASLQPVNEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSIN 348
Cdd:COG3850 102 LLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFN 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 349 TLSVNLKDRIDRLNVANTKLQQDIERERQLEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYTDVILEETEN 428
Cdd:COG3850 182 RMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAG 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 429 MNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSILVKANRSRIEQVVVNLLSNAIR 508
Cdd:COG3850 262 LLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALL 341
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1260132260 509 YTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVK 572
Cdd:COG3850 342 ELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVD 405
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
477-574 |
1.22e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 70.62 E-value: 1.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 477 QVNID-ADPSILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDA 555
Cdd:cd16947 2 QVEINiPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90
....*....|....*....
gi 1260132260 556 SRSRHTGGTGLGLSIVKNI 574
Cdd:cd16947 82 SRNSAKQGNGLGLTITKRL 100
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
473-576 |
9.79e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 68.43 E-value: 9.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 473 EKHLQVNIDADPSILVKANRSRIEQVVVNLLSNAIRYTpdGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYR 552
Cdd:cd16954 16 RKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQR 93
|
90 100
....*....|....*....|....
gi 1260132260 553 LDASRSrhtgGTGLGLSIVKNILD 576
Cdd:cd16954 94 LDEQRP----GQGLGLAIAKEIVE 113
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
368-578 |
1.42e-13 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 73.94 E-value: 1.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 368 LQQDIERERQLEkTRKEFISGVSHELKTPLSVIRSFAEgIKDGVSKDTSY---YTDVILEETENMNRLIVEMLELAKLES 444
Cdd:PRK13837 437 LERRLEHARRLE-AVGTLASGIAHNFNNILGAILGYAE-MALNKLARHSRaarYIDEIISAGARARLIIDQILAFGRKGE 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 445 GTYKldmtTFSIGELTQQVYTKLLFSMEEK-HLQVNIDADPSIlVKANRSRIEQVVVNLLSNAIR-YTPDGE-KIQVSII 521
Cdd:PRK13837 515 RNTK----PFDLSELVTEIAPLLRVSLPPGvELDFDQDQEPAV-VEGNPAELQQVLMNLCSNAAQaMDGAGRvDISLSRA 589
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 522 E-------------AEDTVKVEIENTGNPIPEESLEKIWDRFYrldASRSrhtGGTGLGLSIVKNILDLH 578
Cdd:PRK13837 590 KlrapkvlshgvlpPGRYVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAH 653
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
367-585 |
5.38e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 70.49 E-value: 5.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 367 KLQQDIERERQlEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSkDTSY--YTDVILEETENMnRLIVEMLeLAKLES 444
Cdd:PRK11073 116 RLSQEQLQHAQ-QVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALP-DPALteYTKVIIEQADRL-RNLVDRL-LGPQRP 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 445 GTYkldmTTFSIGELTQQVYTklLFSMEEKHlQVNI--DADPSIL-VKANRSRIEQVVVNLLSNAIR-YTPDGEKI---- 516
Cdd:PRK11073 192 GTH----VTESIHKVAERVVQ--LVSLELPD-NVRLirDYDPSLPeLAHDPDQIEQVLLNIVRNALQaLGPEGGTItlrt 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 517 ----QVSI------IEAedtvKVEIENTGNPIPEEslekIWDR-FYRLDASRSrhtGGTGLGLSIVKNILDLH------- 578
Cdd:PRK11073 265 rtafQLTLhgeryrLAA----RIDIEDNGPGIPPH----LQDTlFYPMVSGRE---GGTGLGLSIARNLIDQHsgkieft 333
|
250
....*....|.
gi 1260132260 579 ----HAEYGVY 585
Cdd:PRK11073 334 swpgHTEFSVY 344
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-584 |
8.47e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 64.75 E-value: 8.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 492 RSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldasRSRHTG-GTGLGLSI 570
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSL 75
|
90
....*....|....
gi 1260132260 571 VKNILDLHHAEYGV 584
Cdd:cd16943 76 SYRIIQKHGGTIRV 89
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-578 |
1.64e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 64.13 E-value: 1.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 497 QVVVNLLSNAIRYTPDGE-KIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNIL 575
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQII 82
|
...
gi 1260132260 576 DLH 578
Cdd:cd16953 83 EAH 85
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-578 |
2.04e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 63.62 E-value: 2.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTpdGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSrhTGGTGLGLSIVKNI 574
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
....
gi 1260132260 575 LDLH 578
Cdd:cd16950 77 SDAH 80
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
340-602 |
1.16e-11 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 66.80 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 340 IGGLSGSINTLSVNLKDRIdRLNVANTKLQQDIER-ERQLEKTRK--EFISGVSHELKTPLSVIRSFAEgikdgvskdts 416
Cdd:COG3290 145 LNGRVLVVNRVPIRDDGRV-VGAVATFRDRTELERlEEELEGVKElaEALRAQRHDFRNHLHTISGLLQ----------- 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 417 yytdviLEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKllfsMEEKHLQVNIDADpSILVKANRSRIE 496
Cdd:COG3290 213 ------LGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAAR----ARERGIDLTIDID-SDLPDLPLSDTD 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 497 QVVV--NLLSNAIRYT---PDGEK-IQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldasRSRHTGGTGLGLSI 570
Cdd:COG3290 282 LVTIlgNLLDNAIEAVeklPEEERrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF-----STKLGEGRGLGLAL 356
|
250 260 270
....*....|....*....|....*....|...
gi 1260132260 571 VKNILDLHHAEYGVYNTTNS-VVFYFNLQKVKE 602
Cdd:COG3290 357 VKQIVEKYGGTIEVESEEGEgTVFTVRLPKEGE 389
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
385-570 |
1.40e-11 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 67.69 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 385 FISGVSHELKTPLSVIRSFAEGIKdgvSKDTSYYTDVILEETENMNRL----IVEMLELAKLESGTYKLDMTTFSIGELT 460
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLLQ---TKELPKGVDRLVTAMNNSSSLllkiISDILDFSKIESEQLKIEPREFSPREVI 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 461 QQVYTKLLFSMEEKHLQVN--IDADPSILVKANRSRIEQVVVNLLSNAIRYTPDGEKI-QVSIieAEDTVKVEIENTGNP 537
Cdd:PRK10841 527 NHITANYLPLVVKKRLGLYcfIEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTGCIVlHVRV--DGDYLSFRVRDTGVG 604
|
170 180 190
....*....|....*....|....*....|...
gi 1260132260 538 IPEESLEKIWDRFYRLDASRSRHTGGTGLGLSI 570
Cdd:PRK10841 605 IPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAI 637
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-578 |
1.76e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 61.19 E-value: 1.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTPDGE--KIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDasrSRHT-GGTGLGLSIV 571
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIV 77
|
....*..
gi 1260132260 572 KNILDLH 578
Cdd:cd16921 78 RKIIERH 84
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
292-584 |
1.78e-11 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 67.06 E-value: 1.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 292 IIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDrlnvantklqqd 371
Cdd:COG2770 219 LLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIE------------ 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 372 iERERQLEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYTDVILEETENMNRLIVEMLELAKLESGTYKLDM 451
Cdd:COG2770 287 -EAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLAL 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 452 TTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSILVKANRSRIEQVVVNLLSNAIRYTPDGEKIQVSIIEAEDTVKVEI 531
Cdd:COG2770 366 ELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAI 445
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1260132260 532 ENTGNPIPEESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLHHAEYGV 584
Cdd:COG2770 446 AAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEA 498
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
373-576 |
2.89e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 62.73 E-value: 2.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 373 ERERqLEKTRKEfISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYTDVILEETENMNRLIVEMLELAKLESGTYKLDMT 452
Cdd:PRK10815 259 ERER-YTKYRTT-LTDLTHSLKTPLAVLQSTLRSLRSGKQMSVEQAEPIMLEQISRISQQIGYYLHRASMRSEHNLLSRE 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 453 TFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSILVKANRSRIEQVVVNLLSNAIRYTPdgEKIQVSIIEAEDTVKVEIE 532
Cdd:PRK10815 337 LHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCL--EFVEISARQTDEHLHIVVE 414
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1260132260 533 NTGNPIPEESLEKIWDRFYRLDASRSrhtgGTGLGLSIVKNILD 576
Cdd:PRK10815 415 DDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITE 454
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-597 |
3.86e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 57.02 E-value: 3.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTPDGEK------IQVSIiEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASrsrhtgGTGLGL 568
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreltIRTSP-ADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGL 73
|
90 100 110
....*....|....*....|....*....|
gi 1260132260 569 SIVKNILDLHHAEYGVY-NTTNSVVFYFNL 597
Cdd:cd16920 74 SICRSIIEAHGGRLSVEsPAGGGATFQFTL 103
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
365-566 |
6.45e-10 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 62.26 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 365 NTKLQQdieRERQLEKT---RKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYT-DVILEETENMNRLIVEMLELA 440
Cdd:PRK10618 433 NKKLQQ---AQREYEKNqqaRKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPElDQLAEQSDVLVRLVDNIQLLN 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 441 KLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQ--VNIDADPSILVKANRSRIEQVVVNLLSNAIRYTPDGeKIQV 518
Cdd:PRK10618 510 MLETQDWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQllIHNHLKAEQLRIGDRDALRKILLLLLNYAITTTAYG-KITL 588
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1260132260 519 SII---EAEDTVKVEIENTGNPIPEESLEKIwdRFYRL-DASRSRHTGGTGL 566
Cdd:PRK10618 589 EVDqdeSSPDRLTIRILDTGAGVSIKELDNL--HFPFLnQTQGDRYGKASGL 638
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-596 |
9.51e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 56.14 E-value: 9.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVvnllSNAIRYTPDGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYrlDASRSRHTG-GTGLGLSIVKN 573
Cdd:cd16948 10 IGQIV----SNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF--TGENGRNFQeSTGMGLYLVKK 83
|
90 100
....*....|....*....|....*....
gi 1260132260 574 ILD-LHHA-----EYGVYNTtnsVVFYFN 596
Cdd:cd16948 84 LCDkLGHKidvesEVGEGTT---FTITFP 109
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
206-370 |
1.06e-09 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 61.19 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 206 AEVRLANDIETLQAVQYFADMIREGTSNSNQLSTFILDGGENIKNSIFVKPIIENGKITEYAFAIASLQPVNEAMLVLKD 285
Cdd:COG0840 103 LALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALA 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 286 YYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDRLNVAN 365
Cdd:COG0840 183 LLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESA 262
|
....*
gi 1260132260 366 TKLQQ 370
Cdd:COG0840 263 EQVAS 267
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
310-354 |
1.90e-08 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 50.52 E-value: 1.90e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1260132260 310 VKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNL 354
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
307-359 |
4.41e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 49.55 E-value: 4.41e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1260132260 307 KIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRID 359
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-578 |
6.09e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 51.25 E-value: 6.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTP--DGEKIQVSIIEAEDTV---------KVEIENTGNPIPEESLEKIwdrFYRLDASRSrhtGG 563
Cdd:cd16918 1 LIQVFLNLVRNAAQALAgsGGEIILRTRTQRQVTLghprhrlalRVSVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90
....*....|....*
gi 1260132260 564 TGLGLSIVKNILDLH 578
Cdd:cd16918 75 TGLGLAIAQNIVSQH 89
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-578 |
1.39e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 49.76 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 495 IEQVVVNLLSNAIRYTPDGE--KIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldasRSRHTG-GTGLGLSIV 571
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVEnpRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSIS 75
|
....*..
gi 1260132260 572 KNILDLH 578
Cdd:cd16976 76 YGIVEEH 82
|
|
| HAMP |
pfam00672 |
HAMP domain; |
305-356 |
1.60e-07 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 48.00 E-value: 1.60e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1260132260 305 YSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKD 356
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
491-578 |
1.92e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 46.76 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 491 NRSRIEQVVVNLLSNA---IRYTPDGeKIQVSI---IEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldASRSRhtgGT 564
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaIEGRPSD-VGEVRIrveADQDGRIVLIVCDNGKGFPREMRHRATEPYV---TTRPK---GT 73
|
90
....*....|....
gi 1260132260 565 GLGLSIVKNILDLH 578
Cdd:cd16944 74 GLGLAIVKKIMEEH 87
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
286-576 |
4.74e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.52 E-value: 4.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 286 YYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDRLNVAN 365
Cdd:COG3920 199 LLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVI 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 366 TKLQQDIERERQLEKTRKEFISGVSHELKTPLSVIRSF----AEGIKDGVSKDtsyytdvILEETENmnRLIVemleLAK 441
Cdd:COG3920 279 TERKRAEEELEASLEEKELLLRELHHRVKNNLQVVSSLlrlqARRADDPEARE-------ALEESQN--RIQA----LAL 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 442 LESGTYK-LDMTTFSIGELTQQVYTKLLFSMEEKHLQVNIDADPSILvkanrsRIEQVV-----VN-LLSNAIRY----T 510
Cdd:COG3920 346 VHELLYQsEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVEL------PADAAVplgliLNeLVTNALKHaflsG 419
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1260132260 511 PDGEkIQVSIIEAEDTVKVEIENTGNPIPEEslekiwdrfyrLDASRSRhtggtGLGLSIVKNILD 576
Cdd:COG3920 420 EGGR-IRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVR 468
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
494-597 |
1.64e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.52 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 494 RIEQVVVNLLSNAIRYT----PDGEkIQVSIIEAEDTVKVEIENTGNPIPEESLEkiwdrfyrlDASRSRHTGgtGLGLS 569
Cdd:COG2172 34 DLVLAVSEAVTNAVRHAyggdPDGP-VEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEG--GRGLF 101
|
90 100 110
....*....|....*....|....*....|
gi 1260132260 570 IVKNILDlhhaEYGVYNTT--NSVVFYFNL 597
Cdd:COG2172 102 LIRRLMD----EVEYESDPggTTVRLVKRL 127
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
496-571 |
2.80e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 43.52 E-value: 2.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260132260 496 EQVVVNLLSNAIRYTPDGEKIQVSI---------------IEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldasRSRH 560
Cdd:cd16919 2 ELAILNLAVNARDAMPEGGRLTIETsnqrvdadyalnyrdLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFF-----TTKE 76
|
90
....*....|..
gi 1260132260 561 TG-GTGLGLSIV 571
Cdd:cd16919 77 VGkGTGLGLSMV 88
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| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
498-572 |
4.77e-04 |
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Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 39.96 E-value: 4.77e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1260132260 498 VVVNLLSNAIRY---TPDGEK-IQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYrldasRSRHTGGTGLGLSIVK 572
Cdd:cd16915 4 IVGNLIDNALDAlaaTGAPNKqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLALVR 77
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| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
497-593 |
3.20e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 37.25 E-value: 3.20e-03
10 20 30 40 50 60 70 80
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gi 1260132260 497 QVVVN-LLSNAIRYTPDGEK---IQVSIIEAEDTVKVEIENTGNPIPeeslekiwdrfYRLDASRSRHTGGTGLGLSIVK 572
Cdd:cd16936 2 ELAVSeAVTNAVRHAYRHDGpgpVRLELDLDPDRLRVEVTDSGPGFD-----------PLRPADPDAGLREGGRGLALIR 70
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90 100
....*....|....*....|.
gi 1260132260 573 NILDLHHAEYGVYNTTNSVVF 593
Cdd:cd16936 71 ALMDEVGYRRTPGGKTVWLEL 91
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