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Conserved domains on  [gi|1260198286|gb|PEX40256|]
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lipase [Bacillus cereus]

Protein Classification

esterase/lipase family protein( domain architecture ID 10787203)

esterase/lipase family protein is an alpha/beta hydrolase, such as triacylglycerol lipase that catalyzes the hydrolysis of a triacylglycerol to form the corresponding diacylglycerol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0016787|GO:0016042

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
30-192 1.06e-18

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


:

Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 81.03  E-value: 1.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198286  30 QQNNYPIILVNGFAGWGReemlgvkYWggvNDIQEDLKRNGYTVHTAAVGPVS-SNWDRACELYAQINGGTVDYGAAhae 108
Cdd:COG1075     2 AATRYPVVLVHGLGGSAA-------SW---APLAPRLRAAGYPVYALNYPSTNgSIEDSAEQLAAFVDAVLAATGAE--- 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198286 109 khghnrfgriysgfapnwsetnKVHLVGHSMGGQTTRTLVQLLkegsygekdyvknhpntkisplfeGGKSYVHSVTTLA 188
Cdd:COG1075    69 ----------------------KVDLVGHSMGGLVARYYLKRL------------------------GGAAKVARVVTLG 102

                  ....
gi 1260198286 189 TPHN 192
Cdd:COG1075   103 TPHH 106
 
Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
30-192 1.06e-18

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 81.03  E-value: 1.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198286  30 QQNNYPIILVNGFAGWGReemlgvkYWggvNDIQEDLKRNGYTVHTAAVGPVS-SNWDRACELYAQINGGTVDYGAAhae 108
Cdd:COG1075     2 AATRYPVVLVHGLGGSAA-------SW---APLAPRLRAAGYPVYALNYPSTNgSIEDSAEQLAAFVDAVLAATGAE--- 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198286 109 khghnrfgriysgfapnwsetnKVHLVGHSMGGQTTRTLVQLLkegsygekdyvknhpntkisplfeGGKSYVHSVTTLA 188
Cdd:COG1075    69 ----------------------KVDLVGHSMGGLVARYYLKRL------------------------GGAAKVARVVTLG 102

                  ....
gi 1260198286 189 TPHN 192
Cdd:COG1075   103 TPHH 106
hCaCC TIGR00868
calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out ...
64-121 2.64e-03

calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out AC found a row in 1A13.INFO that was not parsed out EC found a row in 1A13.INFO that was not parsed out GA found a row in 1A13.INFO that was not parsed out SO found a row in 1A13.INFO that was not parsed out RH found a row in 1A13.INFO that was not parsed out EN found a row in 1A13.INFO that was not parsed out GS found a row in 1A13.INFO that was not parsed out AL found a row in 1A13.INFO that was not parsed out The Epithelial Chloride Channel (E-ClC) Family (TC 1.A.13) found a row in 1A13.INFO that was not parsed out found a row in 1A13.INFO that was not parsed out Mammals have multiple isoforms of epithelial chloride channel proteins. The first member of this family to be characterized was a respiratory epithelium, Ca found a row in 1A13.INFO that was not parsed out 2+-regulated, chloride channel protein isolated from bovine tracheal apical membranes. It was biochemically characterized as a 140 kDa complex. The purified found a row in 1A13.INFO that was not parsed out complex when reconstituted in a planar lipid bilayer behaved as an anion-selective channel. It was regulated by Ca 2+ via a calmodulin kinase II-dependent found a row in 1A13.INFO that was not parsed out mechanism. When the cRNA was injected into Xenopus oocytes, an outward rectifying, DIDS-sensitive, anion conductance was measured. A related gene, found a row in 1A13.INFO that was not parsed out Lu-ECAM, was cloned from the bovine aortic endothelial cell line, BAEC. It is expressed in the lung and spleen but not in the trachea. Homologues are found in found a row in 1A13.INFO that was not parsed out several mammals, and at least three paralogues(hCaCC-1-3) are present in humans, each with different tissue distributions. found a row in 1A13.INFO that was not parsed out [Transport and binding proteins, Anions]


Pssm-ID: 129946 [Multi-domain]  Cd Length: 863  Bit Score: 40.25  E-value: 2.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1260198286  64 EDLKRNGYTVHTAAVGPVSsnwDRACELYAQINGGTVDYGAAHAEKHG-HNRFGRIYSG 121
Cdd:TIGR00868 424 EEVKQSGAIIHTIALGPSA---AKELEELSDMTGGLRFYASDQADNNGlIDAFGALSSG 479
PGAP1 pfam07819
PGAP1-like protein; The sequences found in this family are similar to PGAP1. This is an ...
99-223 2.87e-03

PGAP1-like protein; The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body. This entry also includes Tgl2, a mitochondria protein that serves as a triacylglycerol lipase in budding yeasts.


Pssm-ID: 369540  Cd Length: 233  Bit Score: 38.88  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198286  99 TVDYGAAHAEKHGH-------------NRFGRIYSGFAPnwsETNKVHLVGHSMGGQTTRTLVQLlkegsygeKDYVKNH 165
Cdd:pfam07819  50 SVDFNEELSAFHGRtlldqaeylndaiRYILSLYASGRP---GPTSVILIGHSMGGIVARAALTL--------PNYIPQS 118
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1260198286 166 PNTKIsplfeggksyvhsvtTLATPHNGTTLA-DGSLLLPF--VKDLLITAASLGGNNNLS 223
Cdd:pfam07819 119 VNTII---------------TLSSPHAKPPLTfDGDILKFYerLNAFWRKLYNDGDSNNLS 164
 
Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
30-192 1.06e-18

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 81.03  E-value: 1.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198286  30 QQNNYPIILVNGFAGWGReemlgvkYWggvNDIQEDLKRNGYTVHTAAVGPVS-SNWDRACELYAQINGGTVDYGAAhae 108
Cdd:COG1075     2 AATRYPVVLVHGLGGSAA-------SW---APLAPRLRAAGYPVYALNYPSTNgSIEDSAEQLAAFVDAVLAATGAE--- 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198286 109 khghnrfgriysgfapnwsetnKVHLVGHSMGGQTTRTLVQLLkegsygekdyvknhpntkisplfeGGKSYVHSVTTLA 188
Cdd:COG1075    69 ----------------------KVDLVGHSMGGLVARYYLKRL------------------------GGAAKVARVVTLG 102

                  ....
gi 1260198286 189 TPHN 192
Cdd:COG1075   103 TPHH 106
hCaCC TIGR00868
calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out ...
64-121 2.64e-03

calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out AC found a row in 1A13.INFO that was not parsed out EC found a row in 1A13.INFO that was not parsed out GA found a row in 1A13.INFO that was not parsed out SO found a row in 1A13.INFO that was not parsed out RH found a row in 1A13.INFO that was not parsed out EN found a row in 1A13.INFO that was not parsed out GS found a row in 1A13.INFO that was not parsed out AL found a row in 1A13.INFO that was not parsed out The Epithelial Chloride Channel (E-ClC) Family (TC 1.A.13) found a row in 1A13.INFO that was not parsed out found a row in 1A13.INFO that was not parsed out Mammals have multiple isoforms of epithelial chloride channel proteins. The first member of this family to be characterized was a respiratory epithelium, Ca found a row in 1A13.INFO that was not parsed out 2+-regulated, chloride channel protein isolated from bovine tracheal apical membranes. It was biochemically characterized as a 140 kDa complex. The purified found a row in 1A13.INFO that was not parsed out complex when reconstituted in a planar lipid bilayer behaved as an anion-selective channel. It was regulated by Ca 2+ via a calmodulin kinase II-dependent found a row in 1A13.INFO that was not parsed out mechanism. When the cRNA was injected into Xenopus oocytes, an outward rectifying, DIDS-sensitive, anion conductance was measured. A related gene, found a row in 1A13.INFO that was not parsed out Lu-ECAM, was cloned from the bovine aortic endothelial cell line, BAEC. It is expressed in the lung and spleen but not in the trachea. Homologues are found in found a row in 1A13.INFO that was not parsed out several mammals, and at least three paralogues(hCaCC-1-3) are present in humans, each with different tissue distributions. found a row in 1A13.INFO that was not parsed out [Transport and binding proteins, Anions]


Pssm-ID: 129946 [Multi-domain]  Cd Length: 863  Bit Score: 40.25  E-value: 2.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1260198286  64 EDLKRNGYTVHTAAVGPVSsnwDRACELYAQINGGTVDYGAAHAEKHG-HNRFGRIYSG 121
Cdd:TIGR00868 424 EEVKQSGAIIHTIALGPSA---AKELEELSDMTGGLRFYASDQADNNGlIDAFGALSSG 479
PGAP1 pfam07819
PGAP1-like protein; The sequences found in this family are similar to PGAP1. This is an ...
99-223 2.87e-03

PGAP1-like protein; The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body. This entry also includes Tgl2, a mitochondria protein that serves as a triacylglycerol lipase in budding yeasts.


Pssm-ID: 369540  Cd Length: 233  Bit Score: 38.88  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198286  99 TVDYGAAHAEKHGH-------------NRFGRIYSGFAPnwsETNKVHLVGHSMGGQTTRTLVQLlkegsygeKDYVKNH 165
Cdd:pfam07819  50 SVDFNEELSAFHGRtlldqaeylndaiRYILSLYASGRP---GPTSVILIGHSMGGIVARAALTL--------PNYIPQS 118
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1260198286 166 PNTKIsplfeggksyvhsvtTLATPHNGTTLA-DGSLLLPF--VKDLLITAASLGGNNNLS 223
Cdd:pfam07819 119 VNTII---------------TLSSPHAKPPLTfDGDILKFYerLNAFWRKLYNDGDSNNLS 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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