|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
113-467 |
7.13e-74 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 237.91 E-value: 7.13e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 113 MWIEPKMVTQDESFIKRHIEDRILVERIPIQTKKFTGTIELAKNLETFDHLLKIILVVMAIAGICGLVFSFLGGILITKK 192
Cdd:COG5002 29 LLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 193 LLSSVQNITETMKRIKKNGLNERVPVRENNDELAKLSILF---NEMMNEVETSFTQQKQFVEDASHELRTPLTIIQGHLS 269
Cdd:COG5002 109 ALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLaavERDITELERLEQMRREFVANVSHELRTPLTSIRGYLE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 270 MLNRWGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMhPIASEQVHVNSVLKQVTQNFAML--QTDFQFDMK 347
Cdd:COG5002 189 LLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGEL-KLEKEPVDLAELLEEVVEELRPLaeEKGIELELD 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 348 LDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEaNKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSR 427
Cdd:COG5002 268 LPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPE-GGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSR 346
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1260198523 428 KQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG5002 347 ETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
233-467 |
7.13e-62 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 201.29 E-value: 7.13e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 233 NEMMNEVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNRWGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESE 312
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 313 QMhPIASEQVHVNSVLKQVTQNFAML--QTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEANKyICIESSM 390
Cdd:COG2205 83 KL-SLELEPVDLAELLEEAVEELRPLaeEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGT-ITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1260198523 391 RSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDkaRSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
163-467 |
4.38e-60 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 199.75 E-value: 4.38e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 163 LLKIILVVMAIAGICGLVFSFLGGILITKKLLSSVQNITETMKRIKKNGLNERVPVRENNDELAKLSILFNEMMNEVETS 242
Cdd:COG0642 27 LLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 243 FTQQKQFVEDASHELRTPLTIIQGHLSMLNRwgkNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMhPIASEQV 322
Cdd:COG0642 107 NEAKSRFLANVSHELRTPLTAIRGYLELLLE---ELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKL-ELEPEPV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 323 HVNSVLKQVTQNFAML--QTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEaNKYICIESSMRSGKIKIRII 400
Cdd:COG0642 183 DLAELLEEVVELFRPLaeEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPE-GGTVTVSVRREGDRVRISVE 261
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1260198523 401 DHGTGIPEADLPFVLNRFYRVDkaRSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG0642 262 DTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
245-467 |
3.18e-48 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 174.56 E-value: 3.18e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 245 QQK------QFVEDASHELRTPLTIIQGHLSMLNRWGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMHpIA 318
Cdd:NF033092 365 QEKieqerrEFVANVSHELRTPLTTMRSYLEALADGAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYK-LN 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 319 SEQVHVNSVLKQVTQNFAML--QTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIK 396
Cdd:NF033092 444 KEWVNFNEFFNYIIDRFEMIlkNKNITFKREFPKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGT-ITFRLLETHNRII 522
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1260198523 397 IRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:NF033092 523 ISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLP 593
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
249-466 |
1.66e-46 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 164.30 E-value: 1.66e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 249 FVEDASHELRTPLTIIQGHLSMLNRWGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQmHPIASEQVHVNSVL 328
Cdd:TIGR02966 117 FVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAA-SPLEDEPVDMPALL 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 329 KQVTQNFAML--QTDFQFDMKLDADeAYVSIPSSYLEQIIIIVMDNAVKYTKEaNKYICIESSMRSGKIKIRIIDHGTGI 406
Cdd:TIGR02966 196 DHLRDEAEALsqGKNHQITFEIDGG-VDVLGDEDELRSAFSNLVSNAIKYTPE-GGTITVRWRRDGGGAEFSVTDTGIGI 273
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 407 PEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITF 466
Cdd:TIGR02966 274 APEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
22-467 |
2.66e-42 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 156.01 E-value: 2.66e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 22 STALVFIL--FILYSTLqfivinkwtidyEQKQINRQVTEIAAYFQDKNDTLSS-----KTFENSKEFLNNMIDKHQMIR 94
Cdd:TIGR01386 15 VTALVFALsgFMLYSSL------------ERHFEERDREELQGKLEQVRRFLRDpadldEDIKRLQEKIDDLLVGHSDLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 95 IIGNDGKPIVTVSRDFNEMWIEPKMVT----QDESFIKRHIEDRILVERI---PIQTKKFTGTIELAKNLETFDHLLKII 167
Cdd:TIGR01386 83 LSILNPDGRLLFERAQGAALVPAVAANdallELDQADAKMTHYRSILRSVaalPGGKGRKPVQITVALDINAHTHLLDAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 168 LVVMAIAGICGLVFSFLGGILITKKLLSSVQNITETMKRIKKNGLNERVPVRENNDELAKLSILFNEMMNEVETSFTQQK 247
Cdd:TIGR01386 163 RKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 248 QFVEDASHELRTPLTIIQGH----LSMlNRWGKNDPAVLdkslQSSLKEVDRLNKLVSELLELSRAESEQMHPiASEQVH 323
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLLGQtqvaLSQ-PRTGEEYREVL----ESNLEELERLSRMVSDMLFLARADNGQLAL-ERVRLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 324 VNSVLKQVTQNFAMLQTDFQFDMKLDAdEAYVSIPSSYLEQIIIIVMDNAVKYTKeANKYICIESSMRSGKIKIRIIDHG 403
Cdd:TIGR01386 317 LAAELAKVAEYFEPLAEERGVRIRVEG-EGLVRGDPQMFRRAISNLLSNALRHTP-DGGTITVRIERRSDEVRVSVSNPG 394
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 404 TGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEgTIVTITFP 467
Cdd:TIGR01386 395 PGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
254-467 |
9.25e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 140.10 E-value: 9.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 254 SHELRTPLTIIQGHLSMLNR----WGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRaeseqMHPIASEQVHVNSVLK 329
Cdd:COG5000 209 AHEIKNPLTPIQLSAERLRRkladKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFAR-----LPEPQLEPVDLNELLR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 330 QVT--QNFAMLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVkytkEA---NKYICIESSMRSGKIKIRIIDHGT 404
Cdd:COG5000 284 EVLalYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAI----EAieeGGEIEVSTRREDGRVRIEVSDNGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1260198523 405 GIPEADLPFVLNRFYrvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG5000 360 GIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
170-472 |
3.32e-34 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 134.38 E-value: 3.32e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 170 VMAIAGICGLVFsfLGGI--LITKKLLSSVQNITETMKRIKKNGLNERVPVReNNDELAKLSILFNEM-------MNEVE 240
Cdd:NF040691 189 TLLLGGLALVVL--LGLIawLVTRQVVAPVRSAARTAERFAAGDLSERMPVK-GEDDLARLARSFNQMadslqrqIRQLE 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 241 TSFTQQKQFVEDASHELRTPLTIIQ--GHLSMLNRwGKNDPAVlDKSLQSSLKEVDRLNKLVSELLELSR--AESEQMHP 316
Cdd:NF040691 266 ELSRLQQRFVSDVSHELRTPLTTIRmaADVIHDSR-DDFDPAT-ARSAELLHTELDRFESLLSDLLEISRfdAGAAELDV 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 317 iasEQVHVNSVLKQVTQNFAMLQTDFQFDMKLDADEAYV--SIPSSYLEQIIIIVMDNAVKYTKEANKYICIESSMRSgk 394
Cdd:NF040691 344 ---EPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVvaEVDPRRVERVLRNLVVNAIEHGEGKPVVVTVAQDDTA-- 418
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1260198523 395 IKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFPDTTHE 472
Cdd:NF040691 419 VAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPRVAGD 496
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
177-467 |
1.36e-33 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 129.73 E-value: 1.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 177 CGLVFSFLGGILITKKLLSSVQNITETMKRIKKNGLNERVPVRENND-ELAKLSILFNEMMNEVETSftqqkqfVEDAS- 254
Cdd:NF012226 68 CGSVISLIIGMKLAQRFIVPINFLADAAKKISQGDLSARAEDSQIHSaEISELMHNFNDMAQKLESS-------VKNAQv 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 255 ------HELRTPLTIIQGHLS-MLNRWGKNDPAvLDKSLqssLKEVDRLNKLVSELLELSRAESEQMHpIASEQVHVNSV 327
Cdd:NF012226 141 wnaaiaHELRTPITILQGRLQgILDGVFEPDPA-LFKSL---LNQVEGLSHLVEDLRTLSLVENQQLR-LNYESVDLKDS 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 328 LKQVTQNFAMLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTkEANKyICIESSMRSGKIKIRIIDHGTGIP 407
Cdd:NF012226 216 IEKVLKMFEDRLEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYA-NAGK-LKISSSVIQDDWILQIEDEGPGIA 293
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 408 EADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLeSKENEGTIVTITFP 467
Cdd:NF012226 294 EEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEY-SNSQGNSVFTIKLP 352
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
175-467 |
1.36e-33 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 131.87 E-value: 1.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 175 GICGLVFSFLGGILITKKLLSSVQNITETMKRIKKNGLNERVpVRENNDELAKLSILFNEMMNEVETSFTQQKQFVEDAS 254
Cdd:NF012163 170 VALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRV-TPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADIS 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 255 HELRTPLTIIQGHL-SMLNRWGKNDPAVLDkSLQSslkEVDRLNKLVSELLELSRAESEQM-------HPIASEQVHVNS 326
Cdd:NF012163 249 HELRTPLAVLRAELeAIQDGIRKFTPESLD-SLQA---EVGTLTKLVDDLHDLSMSDEGALayqkasvDLVPLLEVEGGA 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 327 VLKQVTQNFAMLQTDFQFDMKLDADEayvsipsSYLEQIIIIVMDNAVKYTkEANKYICIESSMRSGKIKIRIIDHGTGI 406
Cdd:NF012163 325 FRERFASAGLELEVSLPDSSLVFGDR-------DRLMQLFNNLLENSLRYT-DSGGSLHISASQRPKEVTLTVADSAPGV 396
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1260198523 407 PEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:NF012163 397 SDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
255-467 |
3.39e-33 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 128.76 E-value: 3.39e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 255 HELRTPLTIIQGHLSMLNRW--GKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMHPiaseqVHVNSVLKQVt 332
Cdd:COG4191 151 HEINNPLAAILGNAELLRRRleDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREP-----VDLNELIDEA- 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 333 qnFAMLQTDF-----QFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVkytkEA-----NKYICIESSMRSGKIKIRIIDH 402
Cdd:COG4191 225 --LELLRPRLkargiEVELDLPPDLPPVLGDPGQLEQVLLNLLINAI----DAmeegeGGRITISTRREGDYVVISVRDN 298
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1260198523 403 GTGIPEADLPFVLNRFY---RVDKarsrkqgGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG4191 299 GPGIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
244-467 |
7.11e-33 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 129.36 E-value: 7.11e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 244 TQQKQ-------FVEDASHELRTPLTIIQGHLSMLNrwgknDPAVL----DKSLQSSLKEVDRLNKLVSELLELSRAESE 312
Cdd:PRK11006 195 TQMHQlegarrnFFANVSHELRTPLTVLQGYLEMMQ-----DQPLEgalrEKALHTMREQTQRMEGLVKQLLTLSKIEAA 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 313 QMHPIaSEQVHVN---SVLKQVTQNFAMLQTDFQFDM----KLDADEayvsipssylEQI---IIIVMDNAVKYTKE-AN 381
Cdd:PRK11006 270 PTIDL-NEKVDVPmmlRVLEREAQTLSQGKHTITFEVdnslKVFGNE----------DQLrsaISNLVYNAVNHTPEgTH 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 382 KYICIESSMRSGKIKIRiiDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTI 461
Cdd:PRK11006 339 ITVRWQRVPQGAEFSVE--DNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTR 416
|
....*.
gi 1260198523 462 VTITFP 467
Cdd:PRK11006 417 FSFVLP 422
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
218-467 |
2.06e-32 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 129.13 E-value: 2.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 218 VRENNDELAKLSILFNEMMNEVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNRW--GKNDPAVLDkSLQSSLKEVDR 295
Cdd:COG4251 254 LLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDygDKLDEEGRE-YLERIRDAAER 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 296 LNKLVSELLELSRAESEQMHPiasEQVHVNSVLKQVTQNFAMLQTDFQFDMKLDADEAyVSIPSSYLEQIIIIVMDNAVK 375
Cdd:COG4251 333 MQALIDDLLAYSRVGRQELEF---EPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT-VRGDPTLLRQVFQNLISNAIK 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 376 YTKEANK-YICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDkaRSRKQGGNGLGLSIAKRLVEKYNGAIQLES 454
Cdd:COG4251 409 YSRPGEPpRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVES 486
|
250
....*....|...
gi 1260198523 455 KENEGTIVTITFP 467
Cdd:COG4251 487 EPGEGATFYFTLP 499
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
197-467 |
2.87e-32 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 128.35 E-value: 2.87e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 197 VQNITETMKRIKKNGLNER-----VPVrenndELAKLSILFNEMMNEVETSFTQQKQFVEDASHELRTPLT--IIQGHLS 269
Cdd:PRK09835 213 IRSVSRQIQNITSKDLDVRldpqtVPI-----ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITnlITQTEIA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 270 MLNRWGKNDpavLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMHPiasEQVHVN---SVLKqVTQNFAMLQTDFQFDM 346
Cdd:PRK09835 288 LSQSRSQKE---LEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIP---EKKMLDladEVGK-VFDFFEAWAEERGVEL 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 347 KLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARS 426
Cdd:PRK09835 361 RFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEA-ITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQ 439
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1260198523 427 RKQGGNGLGLSIAKRLVEKYNGAIQLESkENEGTIVTITFP 467
Cdd:PRK09835 440 RKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
362-466 |
5.32e-30 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 112.31 E-value: 5.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKarSRKQGGNGLGLSIAKR 441
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGT-IEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRR 77
|
90 100
....*....|....*....|....*
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITF 466
Cdd:cd00075 78 IVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
255-467 |
7.39e-30 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 119.57 E-value: 7.39e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 255 HELRTPLTIIQGHLSMLNRwgKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMHPiaseqVHVNSVLKQVTQn 334
Cdd:COG3852 144 HEIRNPLTGIRGAAQLLER--ELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREP-----VNLHEVLERVLE- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 335 faMLQTDF----QFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVkytkEA-------------NKYICIESSMRSGKIKI 397
Cdd:COG3852 216 --LLRAEApkniRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAA----EAmpeggtitirtrvERQVTLGGLRPRLYVRI 289
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1260198523 398 RIIDHGTGIPEADL-----PFVlnrfyrvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG3852 290 EVIDNGPGIPEEILdrifePFF-----------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
362-469 |
1.25e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 111.59 E-value: 1.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKaRSRKQGGNGLGLSIAKR 441
Cdd:smart00387 6 LRQVLSNLLDNAIKYTPEGGR-ITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSIVKK 83
|
90 100
....*....|....*....|....*...
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITFPDT 469
Cdd:smart00387 84 LVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
255-467 |
2.49e-28 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 118.15 E-value: 2.49e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 255 HELRTPLTIIQGHLSMLNRWGKNDPAvlDKSLQSSLKEVDRLNKLVSELLELSRAESEQMhpiasEQVHVNSVLKQVTQN 334
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPS--QEYLSVVLREVDRLNKVIDQLLEFSRPRESQW-----QPVSLNALVEEVLQL 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 335 F--AMLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKyTKEANKYICIESSM-RSGKIKIRIIDHGTGIPEADL 411
Cdd:PRK11360 472 FqtAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQ-AISARGKIRIRTWQySDGQVAVSIEDNGCGIDPELL 550
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1260198523 412 PFVLNRFYrvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK11360 551 KKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
254-467 |
8.69e-28 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 115.46 E-value: 8.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 254 SHELRTPLTIIQGHLSMLNrwgkndPAVLDKSLQSS---LKEVDRLNKLVSELLELSRAESEQMhpiasEQVHVNSVLKQ 330
Cdd:COG5809 278 AHEIRNPLTSLKGFIQLLK------DTIDEEQKTYLdimLSELDRIESIISEFLVLAKPQAIKY-----EPKDLNTLIEE 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 331 VT---QNFAMLQtDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEaNKYICIE-SSMRSGKIKIRIIDHGTGI 406
Cdd:COG5809 347 VIpllQPQALLK-NVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPE-GGNITIEtKAEDDDKVVISVTDEGCGI 424
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1260198523 407 PEADLPFVLNRFYrvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG5809 425 PEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
362-470 |
1.70e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 103.22 E-value: 1.70e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANK-YICIEssmRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKarsRKQGGNGLGLSIAK 440
Cdd:pfam02518 6 LRQVLSNLLDNALKHAAKAGEiTVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 1260198523 441 RLVEKYNGAIQLESKENEGTIVTITFPDTT 470
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
188-467 |
1.79e-26 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 111.65 E-value: 1.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 188 LITKKLLSSVQNITETMKRIKKNGLNERVPVReNNDELAKLSILFNEMMNEVETSFTQQKQFVEDASHELRTPLTIIQGH 267
Cdd:PRK10549 183 LLARGLLAPVKRLVEGTHKLAAGDFTTRVTPT-SRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGE 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 268 LSMLN---RwgKNDPAVLDkSLQSslkEVDRLNKLVSELLELSRAESEQMhpiASEQVHVNSV-LKQVT-----QNFAML 338
Cdd:PRK10549 262 LEAIQdgvR--KFTPESVA-SLQA---EVGTLTKLVDDLHQLSLSDEGAL---AYRKTPVDLVpLLEVAggafrERFASR 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 339 QTDFQFDMkldADEAYVSIPSSYLEQIIIIVMDNAVKYTKEANKYIcIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRF 418
Cdd:PRK10549 333 GLTLQLSL---PDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLH-ISAEQRDKTLRLTFADSAPGVSDEQLQKLFERF 408
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1260198523 419 YRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK10549 409 YRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
232-467 |
9.97e-26 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 109.25 E-value: 9.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 232 FNEMMNEVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNRwgKNDPavlDKSLQSSLKEVDRLNKLVSELLELSR--A 309
Cdd:PRK09470 229 FNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRR--RQGE---SKELERIETEAQRLDSMINDLLVLSRnqQ 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 310 ESEQMhpiaSEQVHVNSVLKQVTQN--FAMLQTDFQFDMKLDADEAYV----SIPSSYLEQIIiivmDNAVKYTKEAnky 383
Cdd:PRK09470 304 KNHLE----RETFKANSLWSEVLEDakFEAEQMGKSLTVSAPPGPWPIngnpNALASALENIV----RNALRYSHTK--- 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 384 ICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVT 463
Cdd:PRK09470 373 IEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLT 452
|
....
gi 1260198523 464 ITFP 467
Cdd:PRK09470 453 IWLP 456
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
213-467 |
1.93e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 105.70 E-value: 1.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 213 NERVPV-RENNDELAKLSILFNEMMNEVETsftqqKQFVED----ASHELRTPLTIIQGHLSMLNrwGKNDPAVLDKSLQ 287
Cdd:PRK11100 223 GKPVPLpKLGSSELRELAQALESMRVKLEG-----KAYVEQyvqtLTHELKSPLAAIRGAAELLQ--EDPPPEDRARFTG 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 288 SSLKEVDRLNKLVSELLELSRAESEQmHPIASEQVHVNSVLKQVTQNFAMLQTDFQFDMKLDADEAYVSIPSSYLEQIII 367
Cdd:PRK11100 296 NILTQSARLQQLIDRLLELARLEQRQ-ELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALG 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 368 IVMDNAVKYTKEaNKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFY---RVDKARSrkqgGNGLGLSIAKRLVE 444
Cdd:PRK11100 375 NLLDNAIDFSPE-GGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVAR 449
|
250 260
....*....|....*....|...
gi 1260198523 445 KYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK11100 450 LHGGEVTLRNRPEGGVLATLTLP 472
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
212-467 |
3.93e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 104.30 E-value: 3.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 212 LNERVPVrENNDELAKLSILFNEMMNEVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNRWGKNDPAVLDKslqsslk 291
Cdd:PRK10604 179 LAERIHF-DEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQALNR------- 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 292 EVDRLNKLVSELLELSRAESEQMhPIASEQVHVNSVLKQVTQNFAMLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMD 371
Cdd:PRK10604 251 DIGQLEALIEELLTYARLDRPQN-ELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLN 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 372 NAVKYtkeANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQ 451
Cdd:PRK10604 330 NALRY---AHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVN 406
|
250
....*....|....*.
gi 1260198523 452 LESKENEGTIVTITFP 467
Cdd:PRK10604 407 CDESELGGARFSFSWP 422
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
362-467 |
4.22e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 96.41 E-value: 4.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKYICI---ESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSI 438
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLRVsleEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1260198523 439 AKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
216-471 |
6.53e-22 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 96.58 E-value: 6.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 216 VPVRENNDELAKLSILFNEMMNEVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNRWGKNDPAVLdkslqssLKEVDR 295
Cdd:PRK10755 107 IAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPL-------IARLDQ 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 296 LNKLVSELLELSRAESEqmhpIAS---EQVH-VNSVLKQVTQNF-AMLQTDFQ-FDMKLDADEAYVSIPSSYLEQIIIIV 369
Cdd:PRK10755 180 MMHTVEQLLQLARAGQS----FSSghyQTVKlLEDVILPSQDELsEMLEQRQQtLLLPESAADITVQGDATLLRLLLRNL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 370 MDNAVKYTKEaNKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDkarsRKQGGNGLGLSIAKRLVEKYNGA 449
Cdd:PRK10755 256 VENAHRYSPE-GSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQ 330
|
250 260
....*....|....*....|...
gi 1260198523 450 IQLES-KENEGTIVTITFPDTTH 471
Cdd:PRK10755 331 FFLQNrQERSGTRAWVWLPKAQN 353
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-467 |
1.25e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 89.31 E-value: 1.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYtkeANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKR 441
Cdd:cd16949 1 LARALENVLRNALRY---SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAER 77
|
90 100
....*....|....*....|....*.
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16949 78 AIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
255-467 |
5.71e-21 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 95.57 E-value: 5.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 255 HELRTPLTIIQGHLSMLnrwgKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMhpiasEQVHVNSVLKQVtqn 334
Cdd:COG5805 296 HEIRNPLTSIKGFLQLL----QPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNK-----EKENINELIQDV--- 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 335 FAMLQTD-----FQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVkytkEA---NKYICIESSMRSGKIKIRIIDHGTGI 406
Cdd:COG5805 364 VTLLETEailhnIQIRLELLDEDPFIYCDENQIKQVFINLIKNAI----EAmpnGGTITIHTEEEDNSVIIRVIDEGIGI 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1260198523 407 PEAdlpfVLNR----FYrvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG5805 440 PEE----RLKKlgepFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
254-467 |
4.79e-20 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 91.85 E-value: 4.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 254 SHELRTPLTIIQGHLSMLNRWGKNDPAVlDKSLQSSLKEVDRLNKLVSELLELSRAESEQMhpiasEQVHVNSVLKQVTQ 333
Cdd:COG5806 209 AHEVRNPLTVVRGFIQLLQEPELSDEKR-KQYIRIALEELDRAEAIITDYLTFAKPQPEKL-----EKIDVSEELEHVID 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 334 NFAMLQTDFQFDMKLD-ADEAYVSIPSSYLEQIIIIVMDNAVkytkEANK---YICIESSMRSGKIKIRIIDHGTGIPEA 409
Cdd:COG5806 283 VLSPYANMNNVEIQTElEPGLYIEGDRQKLQQCLINIIKNGI----EAMPnggTLTIDVSIDKNKVIISIKDTGVGMTKE 358
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1260198523 410 DLPFVLNRFYrvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG5806 359 QLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
214-442 |
1.79e-19 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 90.48 E-value: 1.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 214 ERVP--VRENNDELAKLSILFNEMMnevetsfTQQKQFVEDASHELRTPLTI--IQGHLSMLNRwgkNDPAVLDKSLQSS 289
Cdd:PRK10337 210 TGVPseVRPLVEALNQLFARTHAMM-------VRERRFTSDAAHELRSPLAAlkVQTEVAQLSD---DDPQARKKALLQL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 290 LKEVDRLNKLVSELLELSRAESEQmHPIASEQVHVNSVLKQ--VTQNFAMLQTDFQFDMKLDADEAYVSIPSSYLEQIII 367
Cdd:PRK10337 280 HAGIDRATRLVDQLLTLSRLDSLD-NLQDVAEIPLEDLLQSavMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVR 358
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1260198523 368 IVMDNAVKYTKEANKyICIESSMRSgkikIRIIDHGTGIPEADLPFVLNRFYRvdkARSRKQGGNGLGLSIAKRL 442
Cdd:PRK10337 359 NLLDNAIRYSPQGSV-VDVTLNARN----FTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRI 425
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
254-467 |
7.34e-19 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 88.69 E-value: 7.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 254 SHELRTPLTIIQGhlsMLNRWGKNDPA-VLDKSL-QSSLKEVDRLNKLVSELLELSRAESEQMHPIASEQVhVNSVLKQV 331
Cdd:PRK10364 245 AHEIRNPLSSIKG---LAKYFAERAPAgGEAHQLaQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNDL-INHSLQLV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 332 TQNFAMLQTDFQF-------DMKLDADEayvsipssyLEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGT 404
Cdd:PRK10364 321 SQDANSREIQLRFtandtlpEIQADPDR---------LTQVLLNLYLNAIQAIGQHGV-ISVTASESGAGVKISVTDSGK 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1260198523 405 GIPEADLPFVLNRFYrvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK10364 391 GIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| ArlS_N |
pfam18719 |
ArlS sensor domain; This entry represents the N-terminal extracellular sensor domain of the ... |
41-166 |
7.59e-19 |
|
ArlS sensor domain; This entry represents the N-terminal extracellular sensor domain of the ArlS protein from S. aureus. It recognizes LL-37 antimicrobial peptide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 465847 Cd Length: 127 Bit Score: 82.45 E-value: 7.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 41 INKWTIDYEQKQINRQVTEIAAYFQDKNDTLSSKTFENsKEFLNNMIDKHQMIRIIGNDGKPIVTVSRDFNEMWIEPKMV 120
Cdd:pfam18719 1 FSNWLLDQEKQNVNETMTEVSERLSEIDTELDQESIYS-DSLLQSLSRKNQTIRIYDPDGKLLFSSRNDPVPFKPPKKVK 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1260198523 121 TQDESFIKRHIEDRILVERIPIQTKK--FTGTIELAKNLETFDHLLKI 166
Cdd:pfam18719 80 SEETRKISLVKGKRVLVGRSPIYSKNglIIGYVQVVNSLESYDSLMNK 127
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-465 |
3.99e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 80.25 E-value: 3.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 342 FQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYtKEANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRV 421
Cdd:cd16947 1 FQVEINIPDRPIYANANTEALQRILKNLISNAIKY-GSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1260198523 422 DKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTIT 465
Cdd:cd16947 80 EDSRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVT 123
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
166-467 |
7.84e-18 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 86.62 E-value: 7.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 166 IILVVMAiagicgLVFSFLGGILITKKLlssvQNItetMKRIKKNG---LNERVPVrENNDELAKLSILFNEMMNEVETS 242
Cdd:PRK15347 304 LILVLLT------SVLFLLLRRYLAKPL----WRF---VDIINKTGpaaLEPRLPE-NRLDELGSIAKAYNQLLDTLNEQ 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 243 F----------TQQ----KQFVEDA-----------SHELRTPLTIIQGHLSMLNRwGKNDPA---VLDKSLQSSLKevd 294
Cdd:PRK15347 370 YdtlenkvaerTQAlaeaKQRAEQAnkrksehlttiSHEIRTPLNGVLGALELLQN-TPLTAEqmdLADTARQCTLS--- 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 295 rLNKLVSELLELSRAESEQM--HPiasEQVHVNSVLKQvtqnfAMLQTDFQFDMKLDADEAYVS--IPSSY------LEQ 364
Cdd:PRK15347 446 -LLAIINNLLDFSRIESGQMtlSL---EETALLPLLDQ-----AMLTIQGPAQSKSLTLRTFVGahVPLYLhldslrLRQ 516
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 365 IIIIVMDNAVKYTKEAnkYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKarsrKQGGNGLGLSIAKRLVE 444
Cdd:PRK15347 517 ILVNLLGNAVKFTETG--GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAK 590
|
330 340
....*....|....*....|...
gi 1260198523 445 KYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK15347 591 MMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-467 |
2.00e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 77.89 E-value: 2.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKR 441
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGK-LRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHN 83
|
90 100
....*....|....*....|....*.
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16946 84 IALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-467 |
5.05e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 76.56 E-value: 5.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIiivmDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARsRKQGGNGLGLSIAKR 441
Cdd:cd16948 10 IGQIV----SNALKYSKQGGK-IEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKK 83
|
90 100
....*....|....*....|....*.
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16948 84 LCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
189-467 |
1.46e-16 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 82.52 E-value: 1.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 189 ITKKLLSSVQNITETMKRIKKNGLNERVPVRenNDELAKLSILFN-EMMN------EVETSFTQQKQFVEDASHELRTPL 261
Cdd:TIGR02956 402 AHNLKLQADERQVAQELQEHKESLEQLVAQR--TQELAETNERLNaEVKNhakaraEAEEANRAKSAFLATMSHEIRTPL 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 262 TIIQGHLSMLNrwGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMhPIASEQVHVNSVLKQVTQ------NF 335
Cdd:TIGR02956 480 NGILGTLELLG--DTGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHL-SISPRPFDLNALLDDVHHlmvsraQL 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 336 AMLQTDFQFDMKLdadEAYVSIPSSYLEQIIIIVMDNAVKYTKEANkyICIESSMR-SGKIKIRIIDHGTGIPEADLPFV 414
Cdd:TIGR02956 557 KGIQLRLNIPEQL---PNWWQGDGPRIRQVLINLVGNAIKFTDRGS--VVLRVSLNdDSSLLFEVEDTGCGIAEEEQATL 631
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1260198523 415 LNRFYRVDKarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:TIGR02956 632 FDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
14-467 |
1.72e-16 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 81.60 E-value: 1.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 14 IKWKLTLWSTALVFILFILYSTLQFIVINKWTIDYEQKQINRQVTEIAAYFQDKNDTLSSKTFENSKEFLNNMIDKHQMI 93
Cdd:COG2972 3 KSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 94 RIIGNDGKPIVTVSRDFNEMWIEPKMVTQDESFIKRHIEDRILVERIPIQTKKFTGTIELAKNLETFDHLLKIILVVMAI 173
Cdd:COG2972 83 LLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 174 AGICgLVFSFLGGILITKKLLSSVQNITETMKRIKKnGLNERVPVrENNDELAKLSILFNEMMNEVETSFTQQKQFvEDA 253
Cdd:COG2972 163 ILLL-LLLALLLSYLLSRSITRPIKRLKKAMKKVEK-GDLVRLEV-SGNDEIGILARSFNEMVERIKELIEEVYEL-ELE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 254 SHELRtpltiiqghLSML----------NrwgkndpaVLDkSLQSS--LKEVDRLNKLVSELLELSRA---ESEQMHPIA 318
Cdd:COG2972 239 KKEAE---------LKALqaqinphflfN--------TLN-SIRWLaeLEDPEEAEEMLEALSKLLRYslsKGDELVTLE 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 319 SEQVHVNSVLKqvTQNFaMLQTDFQFDMKLDADEAYVSIPSSYLeQIIIivmDNAVKY---TKEANKYICIESSMRSGKI 395
Cdd:COG2972 301 EELELIKSYLE--IQKL-RFGDRLEVEIEIDEELLDLLIPKLIL-QPLV---ENAIEHgiePKEGGGTIRISIRKEGDRL 373
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1260198523 396 KIRIIDHGTGIPEADLPFVLNRFyrvdkarSRKQGGNGLGLSIAKRLVEKYNGA---IQLESKENEGTIVTITFP 467
Cdd:COG2972 374 VITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIP 441
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
218-467 |
2.09e-16 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 82.47 E-value: 2.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 218 VRENNDELAKLSILFNEMMNEVetsfTQQKQFVEDASHELRTPLTIIQGHLSMLNRWGKNDPAVLDkSLQSSLKEVDRLN 297
Cdd:PRK09959 688 ITETRDLIHALEVERNKAINAT----VAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVE-AISLAYATGQSLL 762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 298 KLVSELLELSRAES--EQMHPiasEQVHVNSVLKQVTQNFAMLQTDFQFDMKLDA---DEAYVSIPSSYLEQIIIIVMDN 372
Cdd:PRK09959 763 GLIGEILDVDKIESgnYQLQP---QWVDIPTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSN 839
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 373 AVKYTKEANkyICIESSM-----RSGKIKIRIIDHGTGIPEADLPFVLNRFYRVdkARSRKQGGNGLGLSIAKRLVEKYN 447
Cdd:PRK09959 840 ALKFTTEGA--VKITTSLghiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQT--SAGRQQTGSGLGLMICKELIKNMQ 915
|
250 260
....*....|....*....|
gi 1260198523 448 GAIQLESKENEGTIVTITFP 467
Cdd:PRK09959 916 GDLSLESHPGIGTTFTITIP 935
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
163-467 |
2.10e-16 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 82.10 E-value: 2.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 163 LLKIILVVMAIAGICGLVFSFLGGIL---ITKkLLSSVQNITETMKRIKKnglneRVPVRENNDELAKLSILFNEMMNEV 239
Cdd:TIGR03785 405 LEKLFNVILAIMSIGTLALFGFASWIswrIRR-LSDDAEAAIDSQGRISG-----AIPASRSRDEIGDLSRSFAQMVARL 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 240 ETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNRwgkndpAVLDKSLQSSLKE----VDRLNKLVSELLELSRAesEQMH 315
Cdd:TIGR03785 479 RQYTHYLENMSSRLSHELRTPVAVVRSSLENLEL------QALEQEKQKYLERaregTERLSMILNNMSEATRL--EQAI 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 316 PIAS-EQVHVNSVLKQVTQNFAMLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEaNKYICIESSMRSGK 394
Cdd:TIGR03785 551 QSAEvEDFDLSEVLSGCMQGYQMTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPE-DGLIEVGLSQNKSH 629
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 395 IKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESK-ENEGTIVTITFP 467
Cdd:TIGR03785 630 ALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISLP 703
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
215-467 |
2.46e-16 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 80.66 E-value: 2.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 215 RVPVRENNDELAKLSILFNEM-MNEVETSFTQQKQFVEDA---SHELRTPLTIIQGHLSMlnrwgkndpavldkslqssl 290
Cdd:COG3290 154 RVPIRDDGRVVGAVATFRDRTeLERLEEELEGVKELAEALraqRHDFRNHLHTISGLLQL-------------------- 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 291 KEVDRLNKLVSELLELSRAESEQMHpIASEQVHVNSVLKQVTQNFAMLQTDFQFDmkLDADEAYVSIPSSYLEQIIIIVM 370
Cdd:COG3290 214 GEYDEALEYIDEISEELQELIDSLL-SRIGNPVLAALLLGKAARARERGIDLTID--IDSDLPDLPLSDTDLVTILGNLL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 371 DNA---VKYTKEANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYrvdkarSRKQGGN-GLGLSIAKRLVEKY 446
Cdd:COG3290 291 DNAieaVEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF------STKLGEGrGLGLALVKQIVEKY 364
|
250 260
....*....|....*....|.
gi 1260198523 447 NGAIQLESKENEGTIVTITFP 467
Cdd:COG3290 365 GGTIEVESEEGEGTVFTVRLP 385
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-467 |
3.66e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 74.16 E-value: 3.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 372 NAVKYTKEANkYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQ 451
Cdd:cd16952 11 NAVKYTPPSD-TITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDARLL 89
|
90
....*....|....*.
gi 1260198523 452 LESKENEGTIVTITFP 467
Cdd:cd16952 90 IASELGKGSRFTCLFP 105
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-466 |
1.73e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 72.44 E-value: 1.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 370 MDNAVKYTKEANKYICIESSMRSGKIKIRiiDHGTGIPEADLPFVLNRFYRVDKarsRKQGGNGLGLSIAKRLVEKYNGA 449
Cdd:cd16940 22 VDNAVRYSPQGSRVEIKLSADDGAVIRVE--DNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKRIVELHGGQ 96
|
90
....*....|....*..
gi 1260198523 450 IQLESKENEGTIVTITF 466
Cdd:cd16940 97 IFLGNAQGGGLEAWVRL 113
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-467 |
1.83e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 72.10 E-value: 1.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYtkeANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSrkQGGNGLGLSIAKR 441
Cdd:cd16950 1 LKRVLSNLVDNALRY---GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQR 75
|
90 100
....*....|....*....|....*.
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16950 76 ISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
232-467 |
2.04e-15 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 78.03 E-value: 2.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 232 FNEMMNEVetsftqqKQFVED-------ASHELRTPLTIIQGHLSMLNrwgkndPAvlDKSLQSSL-KEVDRLNKLVSEL 303
Cdd:PRK09467 215 FNQMAAGI-------KQLEDDrtllmagVSHDLRTPLTRIRLATEMMS------EE--DGYLAESInKDIEECNAIIEQF 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 304 LELSRAESEQmhpiASEQVHVNSVLKQVTQNfamlQTDFQFDMKLDADEAYVSIPSSYL--EQIIIIVMDNAVKYTkeaN 381
Cdd:PRK09467 280 IDYLRTGQEM----PMEMADLNALLGEVIAA----ESGYEREIETALQPGPIEVPMNPIaiKRALANLVVNAARYG---N 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 382 KYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKqgGNGLGLSIAKRLVEKYNGAIQLESKENEGTI 461
Cdd:PRK09467 349 GWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEGGLS 426
|
....*.
gi 1260198523 462 VTITFP 467
Cdd:PRK09467 427 ARAWLP 432
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
245-312 |
2.31e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 70.32 E-value: 2.31e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1260198523 245 QQKQFVEDASHELRTPLTIIQGHLSMLNRWGKNDpaVLDKSLQSSLKEVDRLNKLVSELLELSRAESE 312
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDE--EQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-467 |
2.76e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 71.26 E-value: 2.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 372 NAVKYTKEaNKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKarSRKQGGNGLGLSIAKRLVEKYNGAIQ 451
Cdd:cd16923 11 NAIKYSPE-NTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAIIELHGGSAS 87
|
90
....*....|....*.
gi 1260198523 452 LESkENEGTIVTITFP 467
Cdd:cd16923 88 AEY-DDNHDLFKVRLP 102
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
362-467 |
5.11e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 70.98 E-value: 5.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKR 441
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKE 84
|
90 100
....*....|....*....|....*.
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16925 85 FVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
254-467 |
5.53e-15 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 77.77 E-value: 5.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 254 SHELRTPLTII--QGHLSMLNRWGKNDPavldKSLQSSLKEVDRLN--KLVSELLELSRAESEQMHP----IASEQVhVN 325
Cdd:PRK10490 672 SHDLRTPLTVLfgQAEILTLDLASEGSP----HARQASEIRQQVLNttRLVNNLLDMARIQSGGFNLrkewLTLEEV-VG 746
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 326 SVLKQVtqnfAMLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGTG 405
Cdd:PRK10490 747 SALQML----EPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAE-IGIDAHVEGERLQLDVWDNGPG 821
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1260198523 406 IPEADLPFVLNRFYRVDKARSRKqgGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK10490 822 IPPGQEQLIFDKFARGNKESAIP--GVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
255-467 |
8.57e-15 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 75.76 E-value: 8.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 255 HELRTPLT----IIQG-HLSMLNRWGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMhPIASEQVHVNS--- 326
Cdd:PRK09303 160 HDLRTPLTaaslALETlELGQIDEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTRWEAL-RFNPQKLDLGSlcq 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 327 -VLKQVTQNFAMLQTDFQFDMKLDadeayvsIPSSY-----LEQIIIIVMDNAVKYTKEANKyicIESSM---RSGKIKI 397
Cdd:PRK09303 239 eVILELEKRWLAKSLEIQTDIPSD-------LPSVYadqerIRQVLLNLLDNAIKYTPEGGT---ITLSMlhrTTQKVQV 308
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1260198523 398 RIIDHGTGIPEADLPFV-LNRFyRVDkaRSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK09303 309 SICDTGPGIPEEEQERIfEDRV-RLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
245-312 |
1.51e-14 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 67.98 E-value: 1.51e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1260198523 245 QQKQFVEDASHELRTPLTIIQGHLSMLNRWGKNDPAvlDKSLQSSLKEVDRLNKLVSELLELSRAESE 312
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
245-308 |
1.70e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 68.01 E-value: 1.70e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 245 QQKQFVEDASHELRTPLTIIQGHLSMLNRWGKNDPAvLDKSLQSSLKEVDRLNKLVSELLELSR 308
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEEELLDDEE-QREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
234-467 |
4.31e-14 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 75.01 E-value: 4.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 234 EMMNEVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNrwgkndpavlDKSLQsslKEVDRL-----N------KLVSE 302
Cdd:PRK10841 435 EMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQ----------TKELP---KGVDRLvtamnNssslllKIISD 501
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 303 LLELSRAESEQMHpIASEQVHVNSVLKQVTQNFAMLQTDFQFDMK--LDADeayvsIPSSY------LEQIIIIVMDNAV 374
Cdd:PRK10841 502 ILDFSKIESEQLK-IEPREFSPREVINHITANYLPLVVKKRLGLYcfIEPD-----VPVALngdpmrLQQVISNLLSNAI 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 375 KYTKEANkyICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLES 454
Cdd:PRK10841 576 KFTDTGC--IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDS 653
|
250
....*....|...
gi 1260198523 455 KENEGTIVTITFP 467
Cdd:PRK10841 654 EPGMGSQFTIRIP 666
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
165-467 |
8.29e-14 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 73.57 E-value: 8.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 165 KIILVVMAIAGIcgLVFSFLGGILITKKLLSSVQNITETMKRIKKNGLNERVPVrENNDELAKLS---ILFNEMMNEVET 241
Cdd:COG4192 325 GILLLAIALLSL--LLAVLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPV-DGNDEIGRIArllRVFRDQAIEKTQ 401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 242 SFTQ---QKQFVEDA------------------------SHELRTPLTIIQGHLSMLNRWG-KNDPAVLDKSLQSSLKEV 293
Cdd:COG4192 402 ELETeieERKRIEKNlrqtqdeliqaakmavvgqtmtslAHELNQPLNAMSMYLFSAKKALeQENYAQLPTSLDKIEGLI 481
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 294 DRLNKLVSELLELSRAESEQMHPIASEQVhVNSVLKQVTQNFAMLQTDFQFDmkldaDEAYVSIPSSYLEQIIIIVMDNA 373
Cdd:COG4192 482 ERMDKIIKSLRQFSRKSDTPLQPVDLRQV-IEQAWELVESRAKPQQITLHIP-----DDLMVQGDQVLLEQVLVNLLVNA 555
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 374 VKYTKEAnKYICIESSMRSGKIKIRIIDHGTGIPEAD---LPFVlnrfyrvdkarSRKQGGNGLGLSIAKRLVEKYNGAI 450
Cdd:COG4192 556 LDAVATQ-PQISVDLLSNAENLRVAISDNGNGWPLVDklfTPFT-----------TTKEVGLGLGLSICRSIMQQFGGDL 623
|
330
....*....|....*..
gi 1260198523 451 QLESKENEGTIVTITFP 467
Cdd:COG4192 624 YLASTLERGAMVILEFN 640
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
362-467 |
2.44e-13 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 72.57 E-value: 2.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKYICIES-SMRSGKIKIR--IIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSI 438
Cdd:PRK11107 409 LQQIITNLVGNAIKFTESGNIDILVELrALSNTKVQLEvqIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVI 488
|
90 100
....*....|....*....|....*....
gi 1260198523 439 AKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK11107 489 TQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
237-467 |
3.00e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 71.90 E-value: 3.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 237 NEVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLnrwgkndpavLDKSL----QSSLKEVD----RLNKLVSELLELSR 308
Cdd:PRK11091 274 DALEKASRDKTTFISTISHELRTPLNGIVGLSRIL----------LDTELtaeqRKYLKTIHvsaiTLGNIFNDIIDMDK 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 309 AESEQMHpIASEQVHVNSVLKQVtQNFAMLQT---DFQFDMKLDAD-EAYVSIPSSYLEQIIIIVMDNAVKYTKEANKYI 384
Cdd:PRK11091 344 MERRKLQ-LDNQPIDFTDFLADL-ENLSGLQAeqkGLRFDLEPLLPlPHKVITDGTRLRQILWNLISNAVKFTQQGGVTV 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 385 CIESSMRSgKIKIRIIDHGTGIPEADLPFVLNRFYRV-DKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVT 463
Cdd:PRK11091 422 RVRYEEGD-MLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFT 500
|
....
gi 1260198523 464 ITFP 467
Cdd:PRK11091 501 LTIH 504
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-467 |
6.54e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 64.76 E-value: 6.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYtkeANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKR 441
Cdd:cd16939 1 MARALDNLLRNALRY---AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHR 77
|
90 100
....*....|....*....|....*.
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16939 78 VALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-466 |
7.26e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 64.79 E-value: 7.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANkYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARsRKQGGNGLGLSIAKR 441
Cdd:cd16975 5 LSRALINIISNACQYAPEGG-TVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYIAKN 82
|
90 100
....*....|....*....|....*
gi 1260198523 442 LVEKYNGAIQLESKENEGTIVTITF 466
Cdd:cd16975 83 LVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-466 |
1.56e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 64.58 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 369 VMDNAVKYtkeANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSrkqgGNGLGLSIAKRLVEKYNG 448
Cdd:cd16954 45 LLDNACKW---CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGG 117
|
90
....*....|....*...
gi 1260198523 449 AIQLESKENEGTIVTITF 466
Cdd:cd16954 118 ELSLSDSPLGGARFEVVF 135
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-467 |
2.42e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 63.21 E-value: 2.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 360 SYLEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSrkqgGNGLGLSIA 439
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGR-ITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 1260198523 440 KRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-467 |
3.33e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 62.73 E-value: 3.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKE-ANKYICIESSMRSGKIKIRIIDHGTGIPE--ADLPFVLnrFYRVDkarSRKQ-GGNGLGLS 437
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPrRPPRIEVGAEDVGEEWTFYVRDNGIGIDPeyAEKVFGI--FQRLH---SREEyEGTGVGLA 75
|
90 100 110
....*....|....*....|....*....|
gi 1260198523 438 IAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16921 76 IVRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
218-467 |
6.45e-12 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 68.01 E-value: 6.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 218 VRENNDELAKLSILFNEMMNEVETSFTQQKQFVEDASHELRTPLTIIQG----------------HLSMLNRWGKNDPAV 281
Cdd:PRK11466 416 VKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGtaqlladnpalnaqrdDLRAITDSGESLLTI 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 282 LDKSLQSSLKEVDRLNKLVSEllelsraeseqmHPIASEQVhVNSVLK----QVTQNFAMLQTDFQfdmklDADEAYVSI 357
Cdd:PRK11466 496 LNDILDYSAIEAGGKNVSVSD------------EPFEPRPL-LESTLQlmsgRVKGRPIRLATDIA-----DDLPTALMG 557
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 358 PSSYLEQIIIIVMDNAVKYTKEAnkYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVdkarSRKQGGNGLGLS 437
Cdd:PRK11466 558 DPRRIRQVITNLLSNALRFTDEG--SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQV----SGKRGGTGLGLT 631
|
250 260 270
....*....|....*....|....*....|
gi 1260198523 438 IAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK11466 632 ISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
245-454 |
9.86e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 63.18 E-value: 9.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 245 QQ---KQFVEDASHELRTPLTIIQGHLSMLNRwGKNDPAvLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMHPIaseq 321
Cdd:PRK11073 126 QQvaaRDLVRGLAHEIKNPLGGLRGAAQLLSK-ALPDPA-LTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESI---- 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 322 vhvNSVLKQVTQNFAMlqtDFQFDMKLDADeaY-VSIP-----SSYLEQIIIIVMDNAVKYTKEANKYICIESsmRS--- 392
Cdd:PRK11073 200 ---HKVAERVVQLVSL---ELPDNVRLIRD--YdPSLPelahdPDQIEQVLLNIVRNALQALGPEGGTITLRT--RTafq 269
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1260198523 393 ----GK-----IKIRIIDHGTGIPeADLPFVLnrFYRVDKARsrkQGGNGLGLSIAKRLVEKYNGAIQLES 454
Cdd:PRK11073 270 ltlhGEryrlaARIDIEDNGPGIP-PHLQDTL--FYPMVSGR---EGGTGLGLSIARNLIDQHSGKIEFTS 334
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-467 |
1.30e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 58.18 E-value: 1.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEAN--KYICIESSMRSGK--IKIRIIDHGTGIPEADLPFVLNRFYrvdkarSRKQGGNGLGLS 437
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGceRRELTIRTSPADDraVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 1260198523 438 IAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-467 |
1.47e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 58.07 E-value: 1.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 372 NAVKYTKEANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQ 451
Cdd:cd16915 14 DALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQSVERLGGSIT 88
|
90
....*....|....*.
gi 1260198523 452 LESKENEGTIVTITFP 467
Cdd:cd16915 89 VESEPGGGTTFSIRIP 104
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
212-466 |
1.63e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 63.11 E-value: 1.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 212 LNERVPvRENNDELAKLSILFNemmNEVEtSFTQQKQFVEDASHELRTPLTIIQGHLSMLnRWGKN------DPAVLDks 285
Cdd:PRK10815 237 LDPNPP-RELTSLVRNLNRLLK---NERE-RYTKYRTTLTDLTHSLKTPLAVLQSTLRSL-RSGKQmsveqaEPIMLE-- 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 286 lqsslkEVDRLNKLVSELLElsRAESEQMHPIASEQVH--------VNSVLKQVTQNFAMlqtdfqfDMKLDadeayVSI 357
Cdd:PRK10815 309 ------QISRISQQIGYYLH--RASMRSEHNLLSRELHsvaplldnLTSALNKVYQRKGV-------NITLD-----ISP 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 358 PSSYL-EQ-----IIIIVMDNAVKYTKEankYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSrkqgG 431
Cdd:PRK10815 369 EITFVgEKndfmeVMGNVLDNACKYCLE---FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----G 441
|
250 260 270
....*....|....*....|....*....|....*
gi 1260198523 432 NGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITF 466
Cdd:PRK10815 442 QGLGLSVAREITEQYEGKISAGDSPLGGARMEVIF 476
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-452 |
3.88e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 57.09 E-value: 3.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKyICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRVDKARSrKQGGNGLGLSIAKR 441
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGL-IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHS-GQKSTGLGLAFVQE 82
|
90
....*....|.
gi 1260198523 442 LVEKYNGAIQL 452
Cdd:cd16945 83 VAQLHGGRITL 93
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
254-470 |
1.23e-09 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 60.85 E-value: 1.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 254 SHELRTPLTIIQGHLSM-LNRWGKNDPAVldKSLQSSLKEVDRLNKLVSELLELSRAESEQMHPIA-SEQVHVNSVLKQV 331
Cdd:PRK13837 458 AHNFNNILGAILGYAEMaLNKLARHSRAA--RYIDEIISAGARARLIIDQILAFGRKGERNTKPFDlSELVTEIAPLLRV 535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 332 TqnfamLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEANKyICI--------------ESSMRSGKI-K 396
Cdd:PRK13837 536 S-----LPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGR-VDIslsraklrapkvlsHGVLPPGRYvL 609
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 397 IRIIDHGTGIPEADLPFVLNRFYrvdKARSrkqGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFPDTT 470
Cdd:PRK13837 610 LRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSS 677
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
261-467 |
1.92e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 58.09 E-value: 1.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 261 LTIIQGHLSMLNRWGKNDPAVLDKSLqsslkevDRLNKLVSELLELSRAESEQMHPIASEQVHVNSVLKQVTQNFamlQT 340
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREEL-------EEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERL---LR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 341 DFQFDMKLDADEAYVSIPSSYLEQIIIIV---MDNAVKYTKEANkyICIESSMRSGKIKIRIIDHGTGIPEADLPfvlnr 417
Cdd:COG4585 139 AAGIRVELDVDGDPDRLPPEVELALYRIVqeaLTNALKHAGATR--VTVTLEVDDGELTLTVRDDGVGFDPEAAP----- 211
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1260198523 418 fyrvdkarsrkQGGNGLgLSIAKRlVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG4585 212 -----------GGGLGL-RGMRER-AEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-466 |
2.03e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.89 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYrVDKARSRKQGGN-GLGLSIAK 440
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGQHsGLGLSISR 79
|
90 100
....*....|....*....|....*.
gi 1260198523 441 RLVEKYNGAIQLESKENEGTIVTITF 466
Cdd:cd16953 80 QIIEAHGGISVAENHNQPGQVIGARF 105
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
320-472 |
2.48e-09 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 59.15 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 320 EQVHVNSVLKQVTQNFAMLQTDFQFDMKLDADEAYVSIpssylEQIIIIVM------DNAVKYTKEANKY--ICIESSMR 391
Cdd:COG3920 357 EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPA-----DAAVPLGLilnelvTNALKHAFLSGEGgrIRVSWRRE 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 392 SGKIKIRIIDHGTGIPEadlpfvlnrfyRVDKARSRkqggnGLGLSIAKRLVEKYNGAIQLESkeNEGTIVTITFPDTTH 471
Cdd:COG3920 432 DGRLRLTVSDNGVGLPE-----------DVDPPARK-----GLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPLAEL 493
|
.
gi 1260198523 472 E 472
Cdd:COG3920 494 A 494
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
391-467 |
7.72e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 53.31 E-value: 7.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 391 RSGKIKIRIIDHGTGIPeadlPFVLNRF---YRVDKARsrkqgGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16944 38 QDGRIVLIVCDNGKGFP----REMRHRAtepYVTTRPK-----GTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
346-467 |
1.30e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 50.30 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 346 MKLDADEAYVS--------------IPSSYLEQIIIIV---MDNAVKYT--KEANKYICIESSMRSGKIKIRIIDHGTGI 406
Cdd:COG2172 2 LSLPADLEDLGlarravrallrelgLDEDDADDLVLAVseaVTNAVRHAygGDPDGPVEVELELDPDGLEIEVRDEGPGF 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1260198523 407 PEADLPfvlnrfyrvDKARSRKqgGNGLGLSIAKRLVEkyngAIQLESkENEGTIVTITFP 467
Cdd:COG2172 82 DPEDLP---------DPYSTLA--EGGRGLFLIRRLMD----EVEYES-DPGGTTVRLVKR 126
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
254-469 |
1.55e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 53.52 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 254 SHELRTPLTIIQGHLSMLN---RWGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAES------------EQMHPIA 318
Cdd:PRK13557 171 AHDFNNLLQVMSGYLDVIQaalSHPDADRGRMARSVENIRAAAERAATLTQQLLAFARKQRlegrvlnlnglvSGMGELA 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 319 S----EQVHVNSVLKQVTQNFAMLQTdfQFDMKL--------DA--DEAYVSIPSSYLEqiiIIVMDNAVKYTKEANKYI 384
Cdd:PRK13557 251 ErtlgDAVTIETDLAPDLWNCRIDPT--QAEVALlnvlinarDAmpEGGRVTIRTRNVE---IEDEDLAMYHGLPPGRYV 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 385 CIEssmrsgkikirIIDHGTGIPEADLPFVLNRFYRvdkarSRKQG-GNGLGLSIAKRLVEKYNGAIQLESKENEGTIVT 463
Cdd:PRK13557 326 SIA-----------VTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVR 389
|
....*.
gi 1260198523 464 ITFPDT 469
Cdd:PRK13557 390 LYFPAS 395
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-467 |
2.15e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 49.32 E-value: 2.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKYICIESS----MRSGKIKIR------IIDHGTGIPeADL------PFVlnrfyrvdkar 425
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGGEIILRTRtqrqVTLGHPRHRlalrvsVIDNGPGIP-PDLqdtifyPMV----------- 68
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1260198523 426 SRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEgTIVTITFP 467
Cdd:cd16918 69 SGRENGTGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-464 |
2.59e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 48.61 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAV-KYTKEANKYICIESSMRSGKIKIRIIDHGTGIPEADLPFVLNRFYRvdkarSRKQG-GNGLGLSIA 439
Cdd:cd16976 1 IQQVLMNLLQNALdAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*
gi 1260198523 440 KRLVEKYNGAIQLESKENEGTIVTI 464
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTF 100
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-453 |
1.17e-06 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 50.88 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 1 MIKNIMYRIRNLPIKWKLTLWSTALVFILFILYSTLQFIVINKWTIDYEQKQINRQVTEIAAYFQDKNDTLSSKTFENSK 80
Cdd:COG2770 48 ALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 81 EFLNNMIDKHQMIRIIGNDGKPIVTVSRDFNEMWIEPKMVTQDESFIKRHIEDRILVERIPIQTKKFTGTIELAKNLETF 160
Cdd:COG2770 128 LAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 161 DHLLKIILVVMAIAgicgLVFSFLGGILITKKLLSSVQNITETMKRIKKNGLNERVPVrENNDELAKLSILFNEMMNEVE 240
Cdd:COG2770 208 LAALLLLLLLALLA----LLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPV-SRKDEIGELARAFNRMADSLR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 241 TSFTQQKQFVEDASHEL-RTPLTIIQGHLSMLNRWGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMHPIAS 319
Cdd:COG2770 283 ESIEEAEEEEELAEAELaRLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLL 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 320 EQVHVNSVLKQVTQNFAMLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDNAVKYTKEANKYICIESSMRSGKIKIRI 399
Cdd:COG2770 363 LALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAA 442
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 400 IDHGTGIPEADLPFVLNRFYRVDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLE 453
Cdd:COG2770 443 AAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEE 496
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
238-472 |
1.34e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 51.09 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 238 EVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNRwgKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSRAESEQMHPI 317
Cdd:PRK10618 442 EYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQ--TSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 318 ASE---QVHVNSVLKQVTQnfAMLQTDFQ--FDMKLDADEAYVSiPSSYLEQIIIIVMDNAVKYTKEANKYICIESSM-R 391
Cdd:PRK10618 520 QELfslQDLIDEVLPEVLP--AIKRKGLQllIHNHLKAEQLRIG-DRDALRKILLLLLNYAITTTAYGKITLEVDQDEsS 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 392 SGKIKIRIIDHGTGIPEADL-----PFvLNrfyrvDKARSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITF 466
Cdd:PRK10618 597 PDRLTIRILDTGAGVSIKELdnlhfPF-LN-----QTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHL 670
|
....*.
gi 1260198523 467 PDTTHE 472
Cdd:PRK10618 671 KMLAAD 676
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
383-467 |
4.55e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 45.45 E-value: 4.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 383 YICIESSmrsgkikiriiDHGTGIPEADLPFVLNRFYRvdkarSRKQG-GNGLGLSIAKRLVEKYNGAIQLESKENEGTI 461
Cdd:cd16919 47 YVCLEVS-----------DTGSGMPAEVLRRAFEPFFT-----TKEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTT 110
|
....*.
gi 1260198523 462 VTITFP 467
Cdd:cd16919 111 VRIYLP 116
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
149-372 |
1.46e-05 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 47.19 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 149 GTIELAKNLETFDHLLKIILVVMAIAGICGLVFSFLGGILITKKLLSSVQNITETMKRIKKNGLNERVPVReNNDELAKL 228
Cdd:COG3850 98 LLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVS-GRDELGTL 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 229 SILFNEMMNEVETSFTQQKQFVEDASHELRTPLTIIQGHLSMLNRWGKNDPAVLDKSLQSSLKEVDRLNKLVSELLELSR 308
Cdd:COG3850 177 ARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLAL 256
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 309 AESEQMHPIASEQVHVNSVLKQVTQNFAMLQTDFQFDMKLDADEAYVSIPSSYLEQIIIIVMDN 372
Cdd:COG3850 257 NILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLL 320
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
391-467 |
2.38e-05 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 46.83 E-value: 2.38e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1260198523 391 RSGKIKIRIIDHGTGIPEADLPFVLNRFYrvdkarSRKQGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:PRK11086 464 RNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
20-259 |
7.28e-05 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 45.01 E-value: 7.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 20 LWSTALVFILFILYSTLQFIVINKWTIDYEQKQINRQVTEIAAYFQDKNDTLSSKTFENSKEFLNNMIDKHQMIRIIGND 99
Cdd:COG0840 28 ALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 100 GKPIVTVSRDFNEMWIEPKMVTQDESFIKRHIEDRILVERIPIQTKKFTGTIELAKNLETFDHLLKIILVVMAIAGICGL 179
Cdd:COG0840 108 ALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 180 -----VFSFLGGILITKKLLSSVQNITETMKRIKKNGLNERVPVReNNDELAKLSILFNEMMNEVETSFTQQKQFVE--- 251
Cdd:COG0840 188 llalvALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVD-SKDEIGQLADAFNRMIENLRELVGQVRESAEqva 266
|
....*...
gi 1260198523 252 DASHELRT 259
Cdd:COG0840 267 SASEELAA 274
|
|
| HAMP |
pfam00672 |
HAMP domain; |
188-241 |
1.26e-04 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 39.53 E-value: 1.26e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 188 LITKKLLSSVQNITETMKRIKKNGLNERVPVReNNDELAKLSILFNEMMNEVET 241
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVS-GRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
197-235 |
1.33e-04 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 39.35 E-value: 1.33e-04
10 20 30
....*....|....*....|....*....|....*....
gi 1260198523 197 VQNITETMKRIKKNGLNERVPVReNNDELAKLSILFNEM 235
Cdd:cd06225 4 LRRLTEAARRIAEGDLDVRVPVR-SKDEIGELARAFNQM 41
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
210-469 |
2.97e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 43.28 E-value: 2.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 210 NGLN---ERVPVRENNDEL-AKLSILFNEMMNEVETSFTQQKQFVEDasheLRTpltIIQGHLSMLnrwgkndpAVLDKS 285
Cdd:PRK15053 295 NGLSviaNREAIRSGDDLLgAIISFRSKDEISTLNAQLTQIKQYVES----LRT---LRHEHLNWM--------STLNGL 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 286 LQssLKEVDRLnklvselLELSRAESE-QMHPIASEQVHVNSvlKQVTQN-FAMLQTDFQFDMKLdadeayVSIPSSYLE 363
Cdd:PRK15053 360 LQ--MKEYDRV-------LEMVQGESQaQQQLIDSLREAFAD--RQVAGLlFGKVQRARELGLKM------VIVPGSQLS 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 364 Q------------IIIIVMDNAVKY---TKEANKYICIESSMRSGKIKIRIIDHGTGIPEAdlpFVLNRFYRVDKARSRK 428
Cdd:PRK15053 423 QlppgldstefaaIVGNLLDNAFEAslrSDEGNKIVELFLSDEGDDVVIEVADQGCGVPES---LRDKIFEQGVSTRADE 499
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1260198523 429 QGGNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFPDT 469
Cdd:PRK15053 500 PGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKV 540
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
431-467 |
4.46e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 41.03 E-value: 4.46e-04
10 20 30
....*....|....*....|....*....|....*..
gi 1260198523 431 GNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16916 142 GRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
365-458 |
4.72e-04 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 39.51 E-value: 4.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 365 IIIIVMDNA---VKYTKEaNKYICIESSMRSGKIKIRIIDHGTGIpeadlpfvlNRFYRVDKARSRKQGGNGLGLSIAKR 441
Cdd:pfam14501 9 IFGNLLDNAieaCSKIDD-NRFIRLKIREKQNFLIIRIENTYEGE---------LKFEGKLPSTKTKGDGHGIGLKSIRR 78
|
90
....*....|....*..
gi 1260198523 442 LVEKYNGAIQLESKENE 458
Cdd:pfam14501 79 IVKKYGGNLSTEIENGI 95
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
354-467 |
4.89e-04 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 40.79 E-value: 4.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 354 YVSIPSsYLEQIIIIVMDNAVKYTKEANKYIC-----IESSMRSGK--IKIRIIDHGTGIPEADLPFVLNRFY------- 419
Cdd:cd16929 37 FPYVPS-HLYYILFELLKNAMRATVESHGDDSddlppIKVTVAKGDedLTIKISDRGGGIPREDLARLFSYMYstapqps 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 420 ---RVDKARSRKQG---GNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:cd16929 116 lddFSDLISGTQPSplaGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
191-244 |
6.56e-04 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 37.61 E-value: 6.56e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1260198523 191 KKLLSSVQNITETMKRIKKNGLNERVPVrENNDELAKLSILFNEMMNEVETSFT 244
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPV-DGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-458 |
2.60e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 37.94 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 327 VLKQVTQNFAMLQTDFQFDMKLDADEaYVSIPSSYLEQIII--IVMDNAV---KYTKEANKYICIESSMRSGKIKIRIID 401
Cdd:cd16935 1 ALDSLLSEKLELAREKGIEFTIEIDI-PILLPISPLDLCIIfgNLLDNAIeacAKIDKENRFIHLKIRQKKGFLIISIEN 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1260198523 402 HGTGipeaDLPFVLNRFYrvdkarSRKQGGN-GLGLSIAKRLVEKYNGAIQLESKENE 458
Cdd:cd16935 80 SYEG----ELKKKNGLFL------STKKDKNhGIGLKSIREIVKKYNGNLSIEYENGI 127
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-467 |
3.12e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 37.03 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 369 VMDNAVKYTKEAN---KYICIESSMRSGKIKIRIIDHGTGI-PEadlpfvlnrfyrvDKARSRKQGGNGLGLS-IAKRLV 443
Cdd:cd16956 9 IVENAVKHGLSGLldgGRVEITARLDGQHLLLEVEDNGGGMdPD-------------TLARILIRSSNGLGLNlVDKRLR 75
|
90 100
....*....|....*....|....*.
gi 1260198523 444 EKY--NGAIQLESKENEGTIVTITFP 467
Cdd:cd16956 76 QAFgnDYGLDIECAPGEGTRITIRLP 101
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
362-451 |
3.31e-03 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 37.25 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 362 LEQIIIIVMDNAVKYTKEANKYICIESSMRSGKI---------KIRIIDHGTGIPEAdlpfVLNRFYRVDKARSRKqggn 432
Cdd:cd16932 7 LQQVLADFLLNAVRFTPSPGGWVEIKVSPTKKQIgdgvhvihlEFRITHPGQGLPEE----LVQEMFEENQWTTQE---- 78
|
90
....*....|....*....
gi 1260198523 433 GLGLSIAKRLVEKYNGAIQ 451
Cdd:cd16932 79 GLGLSISRKLVKLMNGDVR 97
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
431-467 |
5.51e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.01 E-value: 5.51e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1260198523 431 GNGLGLSIAKRLVEKYNGAIQLESKENEGTIVTITFP 467
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-467 |
5.75e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 35.99 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 372 NAVKYTKEANkyICIESSMRSGKIKIRIIDHGTGIPEADlpfvlnrfyrvdkarSRKQGGNGLgLSIAKRlVEKYNGAIQ 451
Cdd:cd16917 11 NALKHAGASR--VRVTLSYTADELTLTVVDDGVGFDGPA---------------PPGGGGFGL-LGMRER-AELLGGTLT 71
|
90
....*....|....*.
gi 1260198523 452 LESKENEGTIVTITFP 467
Cdd:cd16917 72 IGSRPGGGTRVTARLP 87
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
372-467 |
9.55e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 38.30 E-value: 9.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260198523 372 NAVKYTKEANKYI-CIESSmrSGKIKIRIIDHGTGIPEADLPfvLNRFyrvdkarsrkqggnglGLSI----AKRLveky 446
Cdd:PRK10935 482 NAIKHANASEIAVsCVTNP--DGEHTVSIRDDGIGIGELKEP--EGHY----------------GLNImqerAERL---- 537
|
90 100
....*....|....*....|.
gi 1260198523 447 NGAIQLESKENEGTIVTITFP 467
Cdd:PRK10935 538 GGTLTISQPPGGGTTVSLTFP 558
|
|
| |
