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Conserved domains on  [gi|1261856573|gb|PFK94664|]
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flagellar basal body rod modification protein [Bacillus thuringiensis]

Protein Classification

flagellar hook assembly protein FlgD( domain architecture ID 11482417)

flagellar hook assembly protein FlgD may act as a scaffolding protein required for flagellar hook formation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
flgD PRK06792
flagellar basal body rod modification protein; Validated
 1-190 8.07e-124

flagellar basal body rod modification protein; Validated


:

Pssm-ID: 180695 [Multi-domain]  Cd Length: 190  Bit Score: 347.00  E-value: 8.07e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573   1 MPTVGLNTTSTNHIPLQAGAQKSNVPVNGVQSPVQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMN 80
Cdd:PRK06792    1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVDGDGNKVTGQVETVRLAENNDVQLVINNKVVSLRFV 160
Cdd:PRK06792   81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNDGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFV 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1261856573 161 ERVSDKPIGETNPEDAKKDDQKVTEEVKTT 190
Cdd:PRK06792  161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
 
Name Accession Description Interval E-value
flgD PRK06792
flagellar basal body rod modification protein; Validated
 1-190 8.07e-124

flagellar basal body rod modification protein; Validated


Pssm-ID: 180695 [Multi-domain]  Cd Length: 190  Bit Score: 347.00  E-value: 8.07e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573   1 MPTVGLNTTSTNHIPLQAGAQKSNVPVNGVQSPVQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMN 80
Cdd:PRK06792    1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVDGDGNKVTGQVETVRLAENNDVQLVINNKVVSLRFV 160
Cdd:PRK06792   81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNDGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFV 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1261856573 161 ERVSDKPIGETNPEDAKKDDQKVTEEVKTT 190
Cdd:PRK06792  161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
23-152 1.18e-18

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 80.05  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  23 SNVPVNGVQSpvQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQ 102
Cdd:COG1843     2 ATSSSSSVLS--SLSTSSTSSSSSSSSSLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLESLA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1261856573 103 STMYSTALDGGMKFLGKYVR----GVDGDGNKVTGQVETVRLAENndVQLVINN 152
Cdd:COG1843    80 SSLTSSQALQASSLIGKEVLvegnTISLDGGSASGGFELPSAADS--VTVTITD 131
FlgD pfam03963
Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required ...
 31-100 6.03e-18

Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum. It appears to act as a hook-capping protein to enable assembly of hook protein subunits. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerization and also plays a role in determination of the correct hook length, with the help of the FliK protein. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallization.


Pssm-ID: 427619 [Multi-domain]  Cd Length: 75  Bit Score: 74.20  E-value: 6.03e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  31 QSPVQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDK 100
Cdd:pfam03963   6 SSSTTSTSSSSSTSAKSSSTLGKDDFLKLLTTQLQNQDPLNPMDNTQFTSQLAQFSSVEQIEKLNKTLDS 75
 
Name Accession Description Interval E-value
flgD PRK06792
flagellar basal body rod modification protein; Validated
 1-190 8.07e-124

flagellar basal body rod modification protein; Validated


Pssm-ID: 180695 [Multi-domain]  Cd Length: 190  Bit Score: 347.00  E-value: 8.07e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573   1 MPTVGLNTTSTNHIPLQAGAQKSNVPVNGVQSPVQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMN 80
Cdd:PRK06792    1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVDGDGNKVTGQVETVRLAENNDVQLVINNKVVSLRFV 160
Cdd:PRK06792   81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNDGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFV 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1261856573 161 ERVSDKPIGETNPEDAKKDDQKVTEEVKTT 190
Cdd:PRK06792  161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
flgD PRK11911
flagellar basal body rod modification protein; Provisional
 37-164 6.41e-26

flagellar basal body rod modification protein; Provisional


Pssm-ID: 138812 [Multi-domain]  Cd Length: 140  Bit Score: 96.83  E-value: 6.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  37 SNGVSAGAQKTpgvMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKF 116
Cdd:PRK11911   15 NNAVTSSVSKT---LGKDDFMKLFLTSLQYQDPSSPLDTNEMMSQMAQLSLMEQVANMTTAVDKLSEQAQNSALQSAVNF 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1261856573 117 LGKYVRGVDGDGNKVTGQVETVRLAENN-DVQLVINNKVVSLRFVERVS 164
Cdd:PRK11911   92 IGKDIKGVSLNGEVISGKVESVQQTTNGvMLKLKDNDSLVPMTYVTEIN 140
flgD PRK09618
flagellar hook assembly protein FlgD;
27-166 9.57e-20

flagellar hook assembly protein FlgD;


Pssm-ID: 236594 [Multi-domain]  Cd Length: 142  Bit Score: 80.81  E-value: 9.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  27 VNGVQSPVQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQSTmy 106
Cdd:PRK09618    3 MTGIDSSLWLANSKKAERRTGNQNLGKDDFLKLLITQLQNQDPTNPMEDKEFIAQMAQFSSLEQMTNMNKSMEKLVSS-- 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1261856573 107 staLDGGMKF---LGKYVRGVDGDGNKVTGQVETVRLAENNDVQLVINNKVVSLRFVERVSDK 166
Cdd:PRK09618   81 ---SDGLTKYselIGKEVEWEGEDGEIVSGTVTSVKQKDGDYPLVLDNGTWIVADNVTSVGLK 140
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
23-152 1.18e-18

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 80.05  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  23 SNVPVNGVQSpvQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQ 102
Cdd:COG1843     2 ATSSSSSVLS--SLSTSSTSSSSSSSSSLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLESLA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1261856573 103 STMYSTALDGGMKFLGKYVR----GVDGDGNKVTGQVETVRLAENndVQLVINN 152
Cdd:COG1843    80 SSLTSSQALQASSLIGKEVLvegnTISLDGGSASGGFELPSAADS--VTVTITD 131
FlgD pfam03963
Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required ...
 31-100 6.03e-18

Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum. It appears to act as a hook-capping protein to enable assembly of hook protein subunits. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerization and also plays a role in determination of the correct hook length, with the help of the FliK protein. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallization.


Pssm-ID: 427619 [Multi-domain]  Cd Length: 75  Bit Score: 74.20  E-value: 6.03e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  31 QSPVQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDK 100
Cdd:pfam03963   6 SSSTTSTSSSSSTSAKSSSTLGKDDFLKLLTTQLQNQDPLNPMDNTQFTSQLAQFSSVEQIEKLNKTLDS 75
flgD PRK12812
flagellar basal body rod modification protein; Reviewed
 28-141 8.64e-12

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 139245 [Multi-domain]  Cd Length: 259  Bit Score: 61.81  E-value: 8.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  28 NGVQSPVQQSNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQSTMYS 107
Cdd:PRK12812   21 SASTSGATRTDSSSSTGSNPNSQLDKDAFLKLLLIELQHQDPTDPMDSDKMLTQTSQLAALEMQENTNTTMQKLVEQMQS 100

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1261856573 108 TALDGGMKFLGKYVrGVDGDGNKVTGQVETVRLA 141
Cdd:PRK12812  101 SMSTSALSALGKMA-TVSDNAVKLTGADELIALK 133
flgD PRK06009
flagellar hook assembly protein FlgD;
37-143 1.61e-11

flagellar hook assembly protein FlgD;


Pssm-ID: 235670 [Multi-domain]  Cd Length: 140  Bit Score: 59.34  E-value: 1.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  37 SNGVSAGAQKTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKavdKLQSTMYSTALDGGMKF 116
Cdd:PRK06009   19 STASNSTSAANKASVNYDSFLQLLIAQMKNQDPTDPMDATQYVSQLATFSQVEQSIQTNS---KLDTLLASSSLTQAEGL 95

                          90       100
                  ....*....|....*....|....*..
gi 1261856573 117 LGKYVRGVDGdgnKVTGQVETVRLAEN 143
Cdd:PRK06009   96 IGRTVTSADG---SITGVVKSVTVYSD 119
flgD PRK12634
flagellar basal body rod modification protein; Reviewed
 28-121 1.19e-08

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 183639 [Multi-domain]  Cd Length: 221  Bit Score: 52.62  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  28 NGVQSPVQQSNGVSAGAQ--KTPGVMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQSTM 105
Cdd:PRK12634    2 STIASDLYKSLGLSTSSKtaKKEEALGQADFLKLMTEQLQHQDPLKPMENSAFLGQLAQFSTVQGIGDLNTKVSNFSDSM 81

                          90
                  ....*....|....*.
gi 1261856573 106 YSTALDGGMKFLGKYV 121
Cdd:PRK12634   82 SSDQVLKGAALVGHNV 97
flgD PRK06655
flagellar hook assembly protein FlgD;
23-107 3.08e-08

flagellar hook assembly protein FlgD;


Pssm-ID: 235847 [Multi-domain]  Cd Length: 225  Bit Score: 51.49  E-value: 3.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261856573  23 SNVPVNGVQSPVQQSNGVSAGAQKTPGvMGKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQ 102
Cdd:PRK06655    3 IANTVGSSSTSGLSTTSSSSSSKKGAA-DLQDDFLTLLVAQLKNQDPLNPMDNSQMTSQLAQFSTVSGIEKLNTTLGSLS 81


                  ....*
gi 1261856573 103 STMYS 107
Cdd:PRK06655   82 SQMTS 86
flgD PRK05842
flagellar hook assembly protein FlgD;
53-108 9.71e-06

flagellar hook assembly protein FlgD;


Pssm-ID: 235621 [Multi-domain]  Cd Length: 295  Bit Score: 44.99  E-value: 9.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1261856573  53 KDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQSTMYST 108
Cdd:PRK05842   30 KNAFMKLFLEQLKNQDPTAPMETDKIITQTAQLTQVEMQEENKKTMQEVASAMKSN 85
flgD PRK12633
flagellar basal body rod modification protein; Provisional
 27-98 8.50e-05

flagellar basal body rod modification protein; Provisional


Pssm-ID: 183638 [Multi-domain]  Cd Length: 230  Bit Score: 41.88  E-value: 8.50e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1261856573  27 VNGVQSPVQQSNGVSAGAQKTPGVmgKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAV 98
Cdd:PRK12633    4 VNETTSQAGLALAQAGSNSAAQGI--QDQFLTLLVTQLRNQDPLNPMENAELTSQLAQISTVEGINNLKNTM 73
flgD PRK09619
flagellar hook assembly protein FlgD;
23-96 9.42e-05

flagellar hook assembly protein FlgD;


Pssm-ID: 181996 [Multi-domain]  Cd Length: 218  Bit Score: 41.69  E-value: 9.42e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1261856573  23 SNVPVNGVQSPVQQSNGVSAGAQKtpgvmgKDDFLKLFLSSFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTK 96
Cdd:PRK09619    6 SRNSANVGNQSPAPEGGLPGAEQL------NNQFMTLLVAQIQNQDPLNPADGTEFVSQLAQLSQVQSTENMAK 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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