NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1264924595|gb|PGO59337|]
View 

alpha/beta hydrolase [Priestia megaterium]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 11-269 5.24e-48

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 159.01  E-value: 5.24e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  11 TKLFVRDIG-KGEPVLFLHGWPVNAKMYEYQFTTLpARGIRCIAPDLRGFGKSDAPFTGYSYNQLADDIRMLVERLELKN 89
Cdd:COG0596    12 VRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLER 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  90 YTLVGFSMGGAIAIRYMSRHLGYgVKKLILLGAAAPSFIQKTDFPYGLPseevntiiqntyrdrpnmleefgkkffnqpi 169
Cdd:COG0596    91 VVLVGHSMGGMVALELAARHPER-VAGLVLVDEVLAALAEPLRRPGLAP------------------------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 170 sSAFRGWFQdlgleasghgtiktavSLRDEDLREDLSQIFAETYILHGKKDQICPFDLAKVMNRHISFSTLLPFENSGHG 249
Cdd:COG0596   139 -EALAALLR----------------ALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHF 201

                         250       260
                  ....*....|....*....|
gi 1264924595 250 LFYDEREKVNDTLIELIAKS 269
Cdd:COG0596   202 PPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 11-269 5.24e-48

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 159.01  E-value: 5.24e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  11 TKLFVRDIG-KGEPVLFLHGWPVNAKMYEYQFTTLpARGIRCIAPDLRGFGKSDAPFTGYSYNQLADDIRMLVERLELKN 89
Cdd:COG0596    12 VRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLER 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  90 YTLVGFSMGGAIAIRYMSRHLGYgVKKLILLGAAAPSFIQKTDFPYGLPseevntiiqntyrdrpnmleefgkkffnqpi 169
Cdd:COG0596    91 VVLVGHSMGGMVALELAARHPER-VAGLVLVDEVLAALAEPLRRPGLAP------------------------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 170 sSAFRGWFQdlgleasghgtiktavSLRDEDLREDLSQIFAETYILHGKKDQICPFDLAKVMNRHISFSTLLPFENSGHG 249
Cdd:COG0596   139 -EALAALLR----------------ALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHF 201

                         250       260
                  ....*....|....*....|
gi 1264924595 250 LFYDEREKVNDTLIELIAKS 269
Cdd:COG0596   202 PPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 23-254 7.25e-27

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 104.51  E-value: 7.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  23 PVLFLHGWPVNAKMYEYQFTTLPARGIRCIAPDLRGFGKSDAPFTGYSYNQ--LADDIRMLVERLELKNYTLVGFSMGGA 100
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDDYRTddLAEDLEYILEALGLEKVNLVGHSMGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 101 IAIRYMSRHLGYgVKKLILLGAAAPSFIQKTDFPYGLPS--EEVNTIIQNTYRDRPNMLEEFGKKFFNQPISSAF----- 173
Cdd:pfam00561  82 IALAYAAKYPDR-VKALVLLGALDPPHELDEADRFILALfpGFFDGFVADFAPNPLGRLVAKLLALLLLRLRLLKalpll 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 174 --RGWFQDLGLEASGHGTIKTAVSLRDEDLREDLSQIFAE-TYILHGKKDQICPFDLAKVMNRHISFSTLLPFENSGHGL 250
Cdd:pfam00561 161 nkRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDEpTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAGHFA 240


                  ....
gi 1264924595 251 FYDE 254
Cdd:pfam00561 241 FLEG 244
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 16-109 1.20e-17

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 80.81  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  16 RDIGKGEPVLFLHGWPVNAKMYEYQFTTLPARGiRCIAPDLRGFGKSDAPFTGYSYNQLADDIRMLVERLELKNYTLVGF 95
Cdd:PRK03592   22 IETGEGDPIVFLHGNPTSSYLWRNIIPHLAGLG-RCLAPDLIGMGASDKPDIDYTFADHARYLDAWFDALGLDDVVLVGH 100

                          90
                  ....*....|....
gi 1264924595  96 SMGGAIAIRYMSRH 109
Cdd:PRK03592  101 DWGSALGFDWAARH 114
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 11-269 5.24e-48

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 159.01  E-value: 5.24e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  11 TKLFVRDIG-KGEPVLFLHGWPVNAKMYEYQFTTLpARGIRCIAPDLRGFGKSDAPFTGYSYNQLADDIRMLVERLELKN 89
Cdd:COG0596    12 VRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLER 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  90 YTLVGFSMGGAIAIRYMSRHLGYgVKKLILLGAAAPSFIQKTDFPYGLPseevntiiqntyrdrpnmleefgkkffnqpi 169
Cdd:COG0596    91 VVLVGHSMGGMVALELAARHPER-VAGLVLVDEVLAALAEPLRRPGLAP------------------------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 170 sSAFRGWFQdlgleasghgtiktavSLRDEDLREDLSQIFAETYILHGKKDQICPFDLAKVMNRHISFSTLLPFENSGHG 249
Cdd:COG0596   139 -EALAALLR----------------ALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHF 201

                         250       260
                  ....*....|....*....|
gi 1264924595 250 LFYDEREKVNDTLIELIAKS 269
Cdd:COG0596   202 PPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 23-254 7.25e-27

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 104.51  E-value: 7.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  23 PVLFLHGWPVNAKMYEYQFTTLPARGIRCIAPDLRGFGKSDAPFTGYSYNQ--LADDIRMLVERLELKNYTLVGFSMGGA 100
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDDYRTddLAEDLEYILEALGLEKVNLVGHSMGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 101 IAIRYMSRHLGYgVKKLILLGAAAPSFIQKTDFPYGLPS--EEVNTIIQNTYRDRPNMLEEFGKKFFNQPISSAF----- 173
Cdd:pfam00561  82 IALAYAAKYPDR-VKALVLLGALDPPHELDEADRFILALfpGFFDGFVADFAPNPLGRLVAKLLALLLLRLRLLKalpll 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 174 --RGWFQDLGLEASGHGTIKTAVSLRDEDLREDLSQIFAE-TYILHGKKDQICPFDLAKVMNRHISFSTLLPFENSGHGL 250
Cdd:pfam00561 161 nkRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDEpTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAGHFA 240


                  ....
gi 1264924595 251 FYDE 254
Cdd:pfam00561 241 FLEG 244
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
23-268 2.02e-25

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 100.08  E-value: 2.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  23 PVLFLHGWPVNAKMYEYQFTTLPARGIRCIAPDLRGFGKSDAPfTGY--SYNQLADDIRMLVERLEL---KNYTLVGFSM 97
Cdd:COG2267    30 TVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGP-RGHvdSFDDYVDDLRAALDALRArpgLPVVLLGHSM 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  98 GGAIAIRYMSRHlGYGVKKLILLGAAapsfiqktdfpyglpseevntiiqntyrdrpnmleefgkkFFNQPISSAFRGWF 177
Cdd:COG2267   109 GGLIALLYAARY-PDRVAGLVLLAPA----------------------------------------YRADPLLGPSARWL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 178 QDLgleasghgtiktavslrdeDLREDLSQIFAETYILHGKKDQICP-FDLAKVMNRHISFSTLLPFENSGHGLFYD-ER 255
Cdd:COG2267   148 RAL-------------------RLAEALARIDVPVLVLHGGADRVVPpEAARRLAARLSPDVELVLLPGARHELLNEpAR 208

                         250
                  ....*....|...
gi 1264924595 256 EKVNDTLIELIAK 268
Cdd:COG2267   209 EEVLAAILAWLER 221
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
24-271 2.22e-20

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 87.30  E-value: 2.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  24 VLFLHGwpvnakmyeyqFTTLPA-----------RGIRCIAPDLRGFGKSDAPFTGYSYNQLADDIRMLVERLElKNY-- 90
Cdd:COG1647    18 VLLLHG-----------FTGSPAemrplaealakAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILK-AGYdk 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  91 -TLVGFSMGGAIAIRYMSRHLgyGVKKLILLgaaAPSFiqktdfpyglpseevntiiqnTYRDRPNMLEEFGKKFFNQpi 169
Cdd:COG1647    86 vIVIGLSMGGLLALLLAARYP--DVAGLVLL---SPAL---------------------KIDDPSAPLLPLLKYLARS-- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 170 ssaFRGWFQDLGLEASGHGT-----IKTAVSLRD--EDLREDLSQIFAETYILHGKKDQICPFDLAKVMNRHISFS--TL 240
Cdd:COG1647   138 ---LRGIGSDIEDPEVAEYAydrtpLRALAELQRliREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPdkEL 214

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1264924595 241 LPFENSGHGLFYD-EREKVNDTLIELIAKSSA 271
Cdd:COG1647   215 VWLEDSGHVITLDkDREEVAEEILDFLERLAA 246
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 24-253 5.68e-19

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 83.42  E-value: 5.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  24 VLFLHGWPVNAKMYEYQFTTLPARGIRCIAPDLRGFGKSDaPFTGY--SYNQLADDIRMLVERLELKNYT----LVGFSM 97
Cdd:pfam12146   7 VVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSD-GKRGHvpSFDDYVDDLDTFVDKIREEHPGlplfLLGHSM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  98 GGAIAIRYMSRHlGYGVKKLILlgaAAPSFIQKTDFPYGLpseeVNTIIQNTYRDRPNMLEEFGKKFfnqpiSSAFRG-W 176
Cdd:pfam12146  86 GGLIAALYALRY-PDKVDGLIL---SAPALKIKPYLAPPI----LKLLAKLLGKLFPRLRVPNNLLP-----DSLSRDpE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 177 FQDLgLEA----SGHGTIKTAVSLRD--EDLREDLSQIFAETYILHGKKDQICPFDLAKVMNRHISFS--TLLPFENSGH 248
Cdd:pfam12146 153 VVAA-YAAdplvHGGISARTLYELLDagERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTdkTLKLYPGLYH 231


                  ....*
gi 1264924595 249 GLFYD 253
Cdd:pfam12146 232 ELLNE 236
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 24-261 1.07e-18

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 82.14  E-value: 1.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  24 VLFLHGWPVNAKmyeyQFTTLPARGIRCIAPDLRGFGKSDAPftGYSYNQLADDIRMLVERLELKNYTLVGFSMGGAIAI 103
Cdd:pfam12697   1 VVLVHGAGLSAA----PLAALLAAGVAVLAPDLPGHGSSSPP--PLDLADLADLAALLDELGAARPVVLVGHSLGGAVAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 104 RYMSRHLgygVKKLILLGAAAPSFIQKTDFPYGLPSEEVntIIQNTYRDRPNMLEEFGKKFFNQPissAFRGWFQDLGle 183
Cdd:pfam12697  75 AAAAAAL---VVGVLVAPLAAPPGLLAALLALLARLGAA--LAAPAWLAAESLARGFLDDLPADA---EWAAALARLA-- 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1264924595 184 asghgtikTAVSLRDEDLREDLSQIFAETYILHGkKDQICPFDLAKVMNRHISFSTLLpFENSGHgLFYDEREKVNDT 261
Cdd:pfam12697 145 --------ALLAALALLPLAAWRDLPVPVLVLAE-EDRLVPELAQRLLAALAGARLVV-LPGAGH-LPLDDPEEVAEA 211
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 16-109 1.20e-17

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 80.81  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  16 RDIGKGEPVLFLHGWPVNAKMYEYQFTTLPARGiRCIAPDLRGFGKSDAPFTGYSYNQLADDIRMLVERLELKNYTLVGF 95
Cdd:PRK03592   22 IETGEGDPIVFLHGNPTSSYLWRNIIPHLAGLG-RCLAPDLIGMGASDKPDIDYTFADHARYLDAWFDALGLDDVVLVGH 100

                          90
                  ....*....|....
gi 1264924595  96 SMGGAIAIRYMSRH 109
Cdd:PRK03592  101 DWGSALGFDWAARH 114
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 21-104 3.88e-16

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 76.55  E-value: 3.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  21 GEPVLFLHGWPVNAKMYEYQFTTLPARGIRCIAPDLRGFGKSDAP--FTGYSYNQLADDIRMLVERLELKNYTLVGFSMG 98
Cdd:PRK00870   46 GPPVLLLHGEPSWSYLYRKMIPILAAAGHRVIAPDLIGFGRSDKPtrREDYTYARHVEWMRSWFEQLDLTDVTLVCQDWG 125


                  ....*.
gi 1264924595  99 GAIAIR 104
Cdd:PRK00870  126 GLIGLR 131
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
24-268 8.16e-13

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 66.19  E-value: 8.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  24 VLFLHGWPVNA-KMYEYQFTTLPARGIRCIAPDLRGFGKSDAPFTGYSYNQLADDIRMLVERLEL--KNYTLVGFSMGGA 100
Cdd:COG1506    26 VVYVHGGPGSRdDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAIDYLAARPYVdpDRIGIYGHSYGGY 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 101 IAIRYMSRHLGYgVKKLILLGAAapsfiqkTDFP-YGLPSEEVNTIIQNTYRDRPNMLEEFgkkffnQPISSAfrgwfqd 179
Cdd:COG1506   106 MALLAAARHPDR-FKAAVALAGV-------SDLRsYYGTTREYTERLMGGPWEDPEAYAAR------SPLAYA------- 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 180 lgleasghGTIKTAVslrdedlredlsqifaetYILHGKKDQICPFD----LAKVMNRHISFSTLLPFENSGHGLFYDER 255
Cdd:COG1506   165 --------DKLKTPL------------------LLIHGEADDRVPPEqaerLYEALKKAGKPVELLVYPGEGHGFSGAGA 218

                         250
                  ....*....|...
gi 1264924595 256 EKVNDTLIELIAK 268
Cdd:COG1506   219 PDYLERILDFLDR 231
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 22-122 6.60e-10

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 55.22  E-value: 6.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  22 EPVLFLHGWPVNAKMYEYQFTTLPARGIRCIAPDLRGFGKSDAPftgySYNQLADDIRMLVERLELKNYTLVGFSMGGAI 101
Cdd:COG1075     6 YPVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNGSIED----SAEQLAAFVDAVLAATGAEKVDLVGHSMGGLV 81

                          90       100
                  ....*....|....*....|..
gi 1264924595 102 AIRYMSRHLGYG-VKKLILLGA 122
Cdd:COG1075    82 ARYYLKRLGGAAkVARVVTLGT 103
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 17-103 6.72e-10

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 58.33  E-value: 6.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  17 DIGKGEPVLFLHGWPVNAKMYEYQFTTLPARgIRCIAPDLRGFGKSDAPFT-GYSYNQLADDIRMLVERLELKNYTLVGF 95
Cdd:PRK03204   30 DEGTGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPSGfGYQIDEHARVIGEFVDHLGLDRYLSMGQ 108


                  ....*...
gi 1264924595  96 SMGGAIAI 103
Cdd:PRK03204  109 DWGGPISM 116
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 8-109 6.40e-08

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 53.02  E-value: 6.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595   8 TPKTKLFVRDIGKGE--PVLFLHG-------WPVNakmyeyqFTTLpARGIRCIAPDLRGFGKSDAPFTGYSYNQLADDI 78
Cdd:PRK14875  116 IGGRTVRYLRLGEGDgtPVVLIHGfggdlnnWLFN-------HAAL-AAGRPVIALDLPGHGASSKAVGAGSLDELAAAV 187

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1264924595  79 RMLVERLELKNYTLVGFSMGGAIAIRYMSRH 109
Cdd:PRK14875  188 LAFLDALGIERAHLVGHSMGGAVALRLAARA 218
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 23-120 1.16e-07

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 52.19  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  23 PVLFLHGWPVNAKMYEYQFTTLpARGIRCIAPDLRGFGKSDAPFTGYSYNQLADD----IRMLVERLELKNYTLVGFSMG 98
Cdd:PLN03084  129 PVLLIHGFPSQAYSYRKVLPVL-SKNYHAIAFDWLGFGFSDKPQPGYGFNYTLDEyvssLESLIDELKSDKVSLVVQGYF 207

                          90       100
                  ....*....|....*....|..
gi 1264924595  99 GAIAIRYMSRHlGYGVKKLILL 120
Cdd:PLN03084  208 SPPVVKYASAH-PDKIKKLILL 228
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
43-124 2.43e-06

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 47.08  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  43 TLPARGIRCIAPDLRGFGKSDAPF---TGysynqLADDIRMLVERLE---LKNYTLVGFSMGGAIAIRYMSRHLgyGVKK 116
Cdd:COG2945    50 ALVAAGFAVLRFNFRGVGRSEGEFdegRG-----ELDDAAAALDWLRaqnPLPLWLAGFSFGAYVALQLAMRLP--EVEG 122


                  ....*...
gi 1264924595 117 LILLGAAA 124
Cdd:COG2945   123 LILVAPPV 130
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 24-268 4.71e-06

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 46.83  E-value: 4.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  24 VLFLHGWPVNAKMYEYQFTTLPARGIRCIAPDLRGFGKSDAPFTGYSYNQLAD---DIRMLVERLELKNYTLV--GFSMG 98
Cdd:COG1073    40 VVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEGSPERRDaraAVDYLRTLPGVDPERIGllGISLG 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  99 GAIAIRYMSRHlgYGVKKLILlgaaapsfiqktdfpyglpseevntiiQNTYRDRPNMLEEFGKKFFNQPISSAfrGWFQ 178
Cdd:COG1073   120 GGYALNAAATD--PRVKAVIL---------------------------DSPFTSLEDLAAQRAKEARGAYLPGV--PYLP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595 179 DLGLEAsghgtiktavSLRDE-DLREDLSQIFAETYILHGKKDQICPFDLA-KVMNRHISFSTLLPFENSGH-GLFYDER 255
Cdd:COG1073   169 NVRLAS----------LLNDEfDPLAKIEKISRPLLFIHGEKDEAVPFYMSeDLYEAAAEPKELLIVPGAGHvDLYDRPE 238

                         250
                  ....*....|...
gi 1264924595 256 EKVNDTLIELIAK 268
Cdd:COG1073   239 EEYFDKLAEFFKK 251
PRK05855 PRK05855
SDR family oxidoreductase;
4-79 5.74e-06

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 47.28  E-value: 5.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595   4 FIHVTPKTKLFVRDIG--KGEPVLFLHGWPVNAKMYEYQFTTLPARgIRCIAPDLRGFGKSDAP--FTGYSYNQLADDIR 79
Cdd:PRK05855    6 TVVSSDGVRLAVYEWGdpDRPTVVLVHGYPDNHEVWDGVAPLLADR-FRVVAYDVRGAGRSSAPkrTAAYTLARLADDFA 84
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 23-123 7.26e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 46.83  E-value: 7.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  23 PVLFLHGWPVNAKMYEYQFTTLpARGIRCIAPDLRGFGKSDAP-FTGYSYNQLADdirMLVERLE-------LKNYTLVG 94
Cdd:PLN02894  107 TLVMVHGYGASQGFFFRNFDAL-ASRFRVIAIDQLGWGGSSRPdFTCKSTEETEA---WFIDSFEewrkaknLSNFILLG 182

                          90       100
                  ....*....|....*....|....*....
gi 1264924595  95 FSMGGAIAIRYMSRHLGYgVKKLILLGAA 123
Cdd:PLN02894  183 HSFGGYVAAKYALKHPEH-VQHLILVGPA 210
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 15-239 1.01e-05

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 46.77  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595   15 VRDIGK---GEPVLFLHGWPVNAKMYEYQFTTLpARGIRCIAPDLRGFGKS--------DAPFTGYSYNQLADDIRMLVE 83
Cdd:PLN02980  1362 VHEVGQnaeGSVVLFLHGFLGTGEDWIPIMKAI-SGSARCISIDLPGHGGSkiqnhakeTQTEPTLSVELVADLLYKLIE 1440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595   84 RLELKNYTLVGFSMGGAIAIrYMSRHLGYGVKKLILLgAAAPsfiqktdfpyGLPSEEVNTIIQNTYRDRPNM-----LE 158
Cdd:PLN02980  1441 HITPGKVTLVGYSMGARIAL-YMALRFSDKIEGAVII-SGSP----------GLKDEVARKIRSAKDDSRARMlidhgLE 1508

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  159 EFGKKFFNQPISSAFRGW--FQDLGLEASGHGTIKTAVSL-------RDEDLREDLSQIFAETYILHGKKDQicPF-DLA 228
Cdd:PLN02980  1509 IFLENWYSGELWKSLRNHphFNKIVASRLLHKDVPSLAKLlsdlsigRQPSLWEDLKQCDTPLLLVVGEKDV--KFkQIA 1586

                          250
                   ....*....|.
gi 1264924595  229 KVMNRHISFST 239
Cdd:PLN02980  1587 QKMYREIGKSK 1597
YpfH COG0400
Predicted esterase [General function prediction only];
24-134 2.21e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 41.43  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  24 VLFLHGWPVNAKMYEYQFTTLPARGIRCIAP--------------DLRGF-GKSDAPFTGYSYNQLADDIRMLVERLEL- 87
Cdd:COG0400     8 VVLLHGYGGDEEDLLPLAPELALPGAAVLAPrapvpegpggrawfDLSFLeGREDEEGLAAAAEALAAFIDELEARYGId 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1264924595  88 -KNYTLVGFSMGGAIAIRYMSRHlGYGVKKLILLGAAAPSFIQKTDFP 134
Cdd:COG0400    88 pERIVLAGFSQGAAMALSLALRR-PELLAGVVALSGYLPGEEALPAPE 134
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
46-124 2.65e-04

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 41.67  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  46 ARGIRCIAPDLRGFGKSDapftgysyNQLA--------DDIRMLVERL-ELKNYT---LVGFSMGGAIAIRYMSRHlgyG 113
Cdd:COG0429    88 ARGWDVVRLNFRGCGGEP--------NLLPrlyhsgdtEDLVWVLAHLrARYPYAplyAVGFSLGGNLLLKYLGEQ---G 156

                          90
                  ....*....|.
gi 1264924595 114 VKKLILLGAAA 124
Cdd:COG0429   157 DDAPPLKAAVA 167
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 21-178 3.10e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 40.98  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  21 GEPVL-FLHG-------W-PVNAKMYEYqfttlpargiRCIAPDLRGFGKSdapfTGYSYNQLADDIRMLVERLELKN-- 89
Cdd:PRK11126    1 GLPWLvFLHGllgsgqdWqPVGEALPDY----------PRLYIDLPGHGGS----AAISVDGFADVSRLLSQTLQSYNil 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  90 -YTLVGFSMGGAIAIRYMSRHLGYGVKKLILLGAAapsfiqktdfpYGLPSEEVNTI-IQNtyrDRpnmleEFGKKFFNQ 167
Cdd:PRK11126   67 pYWLVGYSLGGRIAMYYACQGLAGGLCGLIVEGGN-----------PGLQNAEERQArWQN---DR-----QWAQRFRQE 127

                         170
                  ....*....|.
gi 1264924595 168 PISSAFRGWFQ 178
Cdd:PRK11126  128 PLEQVLADWYQ 138
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 1-123 3.59e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 41.36  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595   1 MNYFIHVTPKTKlfvrdiGKGEPVLFLHGWPVNAKMYEYQFTTLpARGIRCIAPDLRGFGKSDAPFtGYSYNQ--LADDI 78
Cdd:PLN02679   74 INYLVKGSPEVT------SSGPPVLLVHGFGASIPHWRRNIGVL-AKNYTVYAIDLLGFGASDKPP-GFSYTMetWAELI 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1264924595  79 RMLVERLELKNYTLVGFSMGG---AIAIRYMSRHLgygVKKLILLGAA 123
Cdd:PLN02679  146 LDFLEEVVQKPTVLIGNSVGSlacVIAASESTRDL---VRGLVLLNCA 190
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
24-109 4.70e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 40.33  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  24 VLFLHGWP-VNAKMYEY--QFTtlpARGIRCIAPDLRGFGKSDAPFTGYSYNQLADDIRMLVERLE-----LKNYT---- 91
Cdd:COG0412    32 VVVLHEIFgLNPHIRDVarRLA---AAGYVVLAPDLYGRGGPGDDPDEARALMGALDPELLAADLRaaldwLKAQPevda 108

                          90       100
                  ....*....|....*....|..
gi 1264924595  92 ----LVGFSMGGAIAIRYMSRH 109
Cdd:COG0412   109 grvgVVGFCFGGGLALLAAARG 130
PLN02578 PLN02578
hydrolase
 19-99 7.70e-04

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 40.21  E-value: 7.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  19 GKGEPVLFLHGWPVNAKMYEYQFTTLpARGIRCIAPDLRGFGKSDAPFTGYS----YNQLADDIRMLVERLELknytLVG 94
Cdd:PLN02578   84 GEGLPIVLIHGFGASAFHWRYNIPEL-AKKYKVYALDLLGFGWSDKALIEYDamvwRDQVADFVKEVVKEPAV----LVG 158


                  ....*
gi 1264924595  95 FSMGG 99
Cdd:PLN02578  159 NSLGG 163
Thioesterase pfam00975
Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of ...
 37-132 1.36e-03

Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.


Pssm-ID: 395776 [Multi-domain]  Cd Length: 223  Bit Score: 38.91  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264924595  37 YEYQFTTLPAR-----GIRCIAPDLRGFGKSDAPftgySYNQLADD-IRMLVERLELKNYTLVGFSMGGAIAIRyMSRHL 110
Cdd:pfam00975  12 SASSFRSLARRlpppaEVLAVQYPGRGRGEPPLN----SIEALADEyAEALRQIQPEGPYALFGHSMGGMLAFE-VARRL 86

                          90       100
                  ....*....|....*....|....*
gi 1264924595 111 ---GYGVKKLILLGAAAPSFIQKTD 132
Cdd:pfam00975  87 erqGEAVRSLFLSDASAPHTVRYEA 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH