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Conserved domains on  [gi|1266074334|gb|PGZ72540|]
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tautomerase family protein [Priestia megaterium]

Protein Classification

tautomerase family protein( domain architecture ID 10216049)

tautomerase family protein similar to Bacillus subtilis tautomerases YusQ and YolI

CATH:  3.30.429.10
Gene Ontology:  GO:0016853
PubMed:  29184004|12051677|18695941
SCOP:  3001770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-118 6.33e-40

Tautomerase enzyme;


:

Pssm-ID: 434035  Cd Length: 82  Bit Score: 128.07  E-value: 6.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074334  38 DRYQIVHQHPAHEMIIEDTGLGFERSKDLVIISVTSKQ-RTEEQKQALYRLIVKELGESCGIQPNDIMISIVENGNADWS 116
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTYLGIERSDDYVIIQITLFAgRSVEQKKALYRALAERLAAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1266074334 117 FG 118
Cdd:pfam14552  81 FG 82
4Oxalocrotonate_Tautomerase super family cl00235
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 2-61 6.08e-11

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


The actual alignment was detected with superfamily member pfam01361:

Pssm-ID: 444774  Cd Length: 60  Bit Score: 53.83  E-value: 6.08e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074334   2 PLLRFDVIEGRDEKELKTLLDAAHRAMLEAFGVPERDRYQIVHQHPAHEMIIEDTGLGFE 61
Cdd:pfam01361   1 PFVNIKLFEGRTDEQKKELIERVTDALVEVLGAPRSAIVVIIEEVPPENWGVGGESVGDR 60
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-118 6.33e-40

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 128.07  E-value: 6.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074334  38 DRYQIVHQHPAHEMIIEDTGLGFERSKDLVIISVTSKQ-RTEEQKQALYRLIVKELGESCGIQPNDIMISIVENGNADWS 116
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTYLGIERSDDYVIIQITLFAgRSVEQKKALYRALAERLAAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1266074334 117 FG 118
Cdd:pfam14552  81 FG 82
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 2-61 6.08e-11

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 53.83  E-value: 6.08e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074334   2 PLLRFDVIEGRDEKELKTLLDAAHRAMLEAFGVPERDRYQIVHQHPAHEMIIEDTGLGFE 61
Cdd:pfam01361   1 PFVNIKLFEGRTDEQKKELIERVTDALVEVLGAPRSAIVVIIEEVPPENWGVGGESVGDR 60
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 66-118 2.34e-06

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 42.06  E-value: 2.34e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1266074334  66 LVIISVTSKqRTEEQKQALYRLIVKELGESCGIQPNDIMISIVENGNADWSFG 118
Cdd:COG1942     2 IINIKLFEG-RTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPENWGIG 53
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 2-49 1.78e-03

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 34.35  E-value: 1.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1266074334   2 PLLRFDVIEGRDEKELKTLLDAAHRAMLEAFGVPERDRYQIVHQHPAH 49
Cdd:COG1942     1 PIINIKLFEGRTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPE 48
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-118 6.33e-40

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 128.07  E-value: 6.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074334  38 DRYQIVHQHPAHEMIIEDTGLGFERSKDLVIISVTSKQ-RTEEQKQALYRLIVKELGESCGIQPNDIMISIVENGNADWS 116
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTYLGIERSDDYVIIQITLFAgRSVEQKKALYRALAERLAAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1266074334 117 FG 118
Cdd:pfam14552  81 FG 82
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 2-61 6.08e-11

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 53.83  E-value: 6.08e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074334   2 PLLRFDVIEGRDEKELKTLLDAAHRAMLEAFGVPERDRYQIVHQHPAHEMIIEDTGLGFE 61
Cdd:pfam01361   1 PFVNIKLFEGRTDEQKKELIERVTDALVEVLGAPRSAIVVIIEEVPPENWGVGGESVGDR 60
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 66-118 2.34e-06

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 42.06  E-value: 2.34e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1266074334  66 LVIISVTSKqRTEEQKQALYRLIVKELGESCGIQPNDIMISIVENGNADWSFG 118
Cdd:COG1942     2 IINIKLFEG-RTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPENWGIG 53
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 2-49 1.78e-03

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 34.35  E-value: 1.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1266074334   2 PLLRFDVIEGRDEKELKTLLDAAHRAMLEAFGVPERDRYQIVHQHPAH 49
Cdd:COG1942     1 PIINIKLFEGRTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPE 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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