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Conserved domains on  [gi|1266074341|gb|PGZ72547|]
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SET domain-containing protein-lysine N-methyltransferase [Priestia megaterium]

Protein Classification

SET domain-containing protein( domain architecture ID 14410642)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 1-116 6.49e-52

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


:

Pssm-ID: 380938  Cd Length: 112  Bit Score: 159.73  E-value: 6.49e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341   1 MIEIKvsaiSDGEFNRGVFAKQDIKKGTLIHEAPVIAYPNKEHDFIEKTTLADYAFEYGVNHTAILLGYGMLFNHSYTPN 80
Cdd:cd10540     1 RLEVK----PSTLKGRGVFATRPIKKGEVIEEAPVIVLPKEEYQHLCKTVLDHYVFSWGDGCLALALGYGSMFNHSYTPN 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1266074341  81 ATYEINFDNHTFDFYAYTDIQAGEEILINYNGDEDD 116
Cdd:cd10540    77 AEYEIDFENQTIVFYALRDIEAGEELTINYGDDLWD 112
 
Name Accession Description Interval E-value
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 1-116 6.49e-52

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 159.73  E-value: 6.49e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341   1 MIEIKvsaiSDGEFNRGVFAKQDIKKGTLIHEAPVIAYPNKEHDFIEKTTLADYAFEYGVNHTAILLGYGMLFNHSYTPN 80
Cdd:cd10540     1 RLEVK----PSTLKGRGVFATRPIKKGEVIEEAPVIVLPKEEYQHLCKTVLDHYVFSWGDGCLALALGYGSMFNHSYTPN 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1266074341  81 ATYEINFDNHTFDFYAYTDIQAGEEILINYNGDEDD 116
Cdd:cd10540    77 AEYEIDFENQTIVFYALRDIEAGEELTINYGDDLWD 112
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1-119 2.03e-35

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 118.53  E-value: 2.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341   1 MIEIKVSAIsdgeFNRGVFAKQDIKKGTLIHEAPVIAYPNKEHDFIE--KTTLADYAFEYGVNHT---AILLGYGMLFNH 75
Cdd:COG2940     7 RIEVRPSPI----HGRGVFATRDIPKGTLIGEYPGEVITWAEAERREphKEPLHTYLFELDDDGVidgALGGNPARFINH 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1266074341  76 SYTPNATYEInfDNHTFDFYAYTDIQAGEEILINYNGDEDDQEL 119
Cdd:COG2940    83 SCDPNCEADE--EDGRIFIVALRDIAAGEELTYDYGLDYDEEEY 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 16-111 1.28e-15

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 67.55  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  16 RGVFAKQDIKKGTLI---HEAPVIAYPNKEHDFIEKTTLADYAF------------EYGVNHTAILLGYGMLF-NHSYTP 79
Cdd:pfam00856   2 RGLFATEDIPKGEFIgeyVEVLLITKEEADKRELLYYDKLELRLwgpylftldedsEYCIDARALYYGNWARFiNHSCDP 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1266074341  80 NATYEINF--DNHTFDFYAYTDIQAGEEILINYN 111
Cdd:pfam00856  82 NCEVRVVYvnGGPRIVIFALRDIKPGEELTIDYG 115
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 2-113 8.07e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 52.72  E-value: 8.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341    2 IEIKVSAISdgefNRGVFAKQDIKKGTLIHE-APVIaYPNKEHDFIEKTTLAD-----YAFEYGVNHT---AILLGYGML 72
Cdd:smart00317   3 LEVFKSPGK----GWGVRATEDIPKGEFIGEyVGEI-ITSEEAEERPKAYDTDgakafYLFDIDSDLCidaRRKGNLARF 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1266074341   73 FNHSYTPNATYEINFDNHTFD--FYAYTDIQAGEEILINYNGD 113
Cdd:smart00317  78 INHSCEPNCELLFVEVNGDDRivIFALRDIKPGEELTIDYGSD 120
 
Name Accession Description Interval E-value
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 1-116 6.49e-52

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 159.73  E-value: 6.49e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341   1 MIEIKvsaiSDGEFNRGVFAKQDIKKGTLIHEAPVIAYPNKEHDFIEKTTLADYAFEYGVNHTAILLGYGMLFNHSYTPN 80
Cdd:cd10540     1 RLEVK----PSTLKGRGVFATRPIKKGEVIEEAPVIVLPKEEYQHLCKTVLDHYVFSWGDGCLALALGYGSMFNHSYTPN 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1266074341  81 ATYEINFDNHTFDFYAYTDIQAGEEILINYNGDEDD 116
Cdd:cd10540    77 AEYEIDFENQTIVFYALRDIEAGEELTINYGDDLWD 112
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1-119 2.03e-35

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 118.53  E-value: 2.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341   1 MIEIKVSAIsdgeFNRGVFAKQDIKKGTLIHEAPVIAYPNKEHDFIE--KTTLADYAFEYGVNHT---AILLGYGMLFNH 75
Cdd:COG2940     7 RIEVRPSPI----HGRGVFATRDIPKGTLIGEYPGEVITWAEAERREphKEPLHTYLFELDDDGVidgALGGNPARFINH 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1266074341  76 SYTPNATYEInfDNHTFDFYAYTDIQAGEEILINYNGDEDDQEL 119
Cdd:COG2940    83 SCDPNCEADE--EDGRIFIVALRDIAAGEELTYDYGLDYDEEEY 124
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 10-120 1.22e-18

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 75.49  E-value: 1.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  10 SDGEFNRGVFAKQDIKKGTLIH-EAPVIAYPNKEHDFIEkttladyafEYGVNHTAILLgYGMLFNHSYTPNATYEINfD 88
Cdd:cd20071     5 SEGSKGRGLVATRDIEPGELILvEKPLVSVPSNSFSLTD---------GLNEIGVGLFP-LASLLNHSCDPNAVVVFD-G 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1266074341  89 NHTFDFYAYTDIQAGEEILINYNGDEDD-----QELL 120
Cdd:cd20071    74 NGTLRVRALRDIKAGEELTISYIDPLLPrterrRELL 110
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 16-111 1.28e-15

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 67.55  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  16 RGVFAKQDIKKGTLI---HEAPVIAYPNKEHDFIEKTTLADYAF------------EYGVNHTAILLGYGMLF-NHSYTP 79
Cdd:pfam00856   2 RGLFATEDIPKGEFIgeyVEVLLITKEEADKRELLYYDKLELRLwgpylftldedsEYCIDARALYYGNWARFiNHSCDP 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1266074341  80 NATYEINF--DNHTFDFYAYTDIQAGEEILINYN 111
Cdd:pfam00856  82 NCEVRVVYvnGGPRIVIFALRDIKPGEELTIDYG 115
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 72-120 1.10e-10

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 57.07  E-value: 1.10e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1266074341  72 LFNHS-YTPNATYEINFDNHTFDFYAYTDIQAGEEILINYnGDEDDQELL 120
Cdd:cd10527   182 MLNHSpDAPNVRYEYDEDEGSFVLVATRDIAAGEEVFISY-GPKSNDELL 230
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 3-111 5.87e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 51.87  E-value: 5.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341   3 EIKVSAISDGEFnrGVFAKQDIKKGTLIheapviaypnkehdfiekttladyafeygvnhtaillGYGMLFNHSYTPNAT 82
Cdd:cd08161     1 EIRPSTIPGAGF--GLFATRDIPKGEVI-------------------------------------GLARFINHSCEPNCE 41

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1266074341  83 YEINFDN---HTFdFYAYTDIQAGEEILINYN 111
Cdd:cd08161    42 FEEVYVGgkpRVF-IVALRDIKAGEELTVDYG 72
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 2-113 8.07e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 52.72  E-value: 8.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341    2 IEIKVSAISdgefNRGVFAKQDIKKGTLIHE-APVIaYPNKEHDFIEKTTLAD-----YAFEYGVNHT---AILLGYGML 72
Cdd:smart00317   3 LEVFKSPGK----GWGVRATEDIPKGEFIGEyVGEI-ITSEEAEERPKAYDTDgakafYLFDIDSDLCidaRRKGNLARF 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1266074341   73 FNHSYTPNATYEINFDNHTFD--FYAYTDIQAGEEILINYNGD 113
Cdd:smart00317  78 INHSCEPNCELLFVEVNGDDRivIFALRDIKPGEELTIDYGSD 120
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 74-124 1.56e-07

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 48.46  E-value: 1.56e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1266074341  74 NHSYTPNAtyEINFD--NHTFDFYAYTDIQAGEEILINYNgDEDDQELLWFDR 124
Cdd:cd10521   213 NHSCVPNA--EITFPenNFTLSLKALRDIQEGEEICISYL-DECQRERSRHSR 262
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 3-116 2.72e-07

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 46.18  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341   3 EIKVSAISDGEFN-RGVFAKQDIKKGTLI--------HEAPVIAYPNKEHD--FIEKTTLADY---AFEYGvNHTAillg 68
Cdd:cd10522     1 KVDISMIPNLSHNgLGLFAAETIAKGEFVgeytgevlDRWEEDRDSVYHYDplYPFDLNGDILvidAGKKG-NLTR---- 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1266074341  69 ygmLFNHSYTPNATYEI---NFDNHTFdFYAYTDIQAGEEILINYNGDEDD 116
Cdd:cd10522    76 ---FINHSDQPNLELIVrtlKGEQHIG-FVAIRDIKPGEELFISYGPKYWK 122
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 18-128 3.88e-07

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 46.12  E-value: 3.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  18 VFAKQDIKKGTLIHEAP-VIAYPNKEHDFIEKTTLADYA--FEYGVNHTAILLGYGMLFNHSYTPNATYEINFDNhTFDF 94
Cdd:cd10524    22 IIATKPIKKGEKIHELCgCIAELSEEEEALLRPGGNDFSvmYSSRKKCSQLWLGPAAFINHDCRPNCKFVPTGKS-TACV 100

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1266074341  95 YAYTDIQAGEEILINYnGDEddqellWFDREDEE 128
Cdd:cd10524   101 KVLRDIEPGEEITVYY-GDN------YFGENNEE 127
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 72-120 3.72e-06

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 44.21  E-value: 3.72e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1266074341  72 LFNHSYTPNATYEINFDNHTFDFYAYTDIQAGEEILINYnGDEDDQELL 120
Cdd:cd19177   191 LLNHSPDVNVKAGFNKSGKCYEIRTGTDYKKGEEVFISY-GPHSNDFLL 238
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 17-113 3.34e-05

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 40.74  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  17 GVFAKQDIKKGTLIHEapviaYPNKEHDFIEKTTLADYAFEYGVNHTAILL-------------GYGMLFNHSYTPNA-- 81
Cdd:cd19211    15 GLIAKRDIKKGEFVNE-----YVGELIDEEECMARIKHAHENDITHFYMLTidkdriidagpkgNYSRFMNHSCQPNCet 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1266074341  82 -TYEINFDNHTfDFYAYTDIQAGEEILINYNGD 113
Cdd:cd19211    90 qKWTVNGDTRV-GLFAVCDIPAGTELTFNYNLD 121
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 17-111 4.34e-05

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 40.32  E-value: 4.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  17 GVFAKQDIKKGTLIHEAPVIAYPNKEH----DFIEKTTLADY---AFEYGVNHTAILLG-YGMLFNHSYTPNATYEI-NF 87
Cdd:cd10531    13 GVKAKEDIQKGEFIIEYVGEVIDKKEFkerlDEYEELGKSNFyilSLSDDVVIDATRKGnLSRFINHSCEPNCETQKwIV 92

                          90       100
                  ....*....|....*....|....*
gi 1266074341  88 DNHTF-DFYAYTDIQAGEEILINYN 111
Cdd:cd10531    93 NGEYRiGIFALRDIPAGEELTFDYN 117
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 72-110 1.58e-04

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 39.59  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1266074341  72 LFNHSYTPNATYeiNFDNHTFDFYAYTDIQAGEEILINY 110
Cdd:cd10536   153 LLNHSCDPNTIR--SFYGNTIVVRATRPIKKGEEITICY 189
SET_SpSET10-like cd19180
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ...
 72-120 2.85e-04

SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b).


Pssm-ID: 380957  Cd Length: 252  Bit Score: 38.86  E-value: 2.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1266074341  72 LFNHSYTPNATYEINFDNHTFDFYAYTDIQAGEEILINYnGDEDDQELL 120
Cdd:cd19180   199 LLNHKPGAKVTWNTTDTSSAFELVSGDDLAKGEQVFNNY-GPKSNEELL 246
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 16-113 6.63e-04

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 37.17  E-value: 6.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  16 RGVFAKQDIKKGTLIHE--APVIAYPNKEHdfIEKTTLAD-------YAFEYG-----VNHTAILLGYGMLFNHSYT-PN 80
Cdd:cd10528    29 RGVIATRPFEKGDFVVEyhGDLITITEAKK--REALYAKDpstgcymYYFQYKgktycVDATKESGRLGRLINHSKKkPN 106

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1266074341  81 -ATYEINFDN--HTFdFYAYTDIQAGEEILINYnGD 113
Cdd:cd10528   107 lKTKLLVIDGvpHLI-LVAKRDIKPGEELLYDY-GD 140
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 73-119 3.23e-03

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 36.01  E-value: 3.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1266074341  73 FNHSYTPNATYEINFDNHTFD------FYAYTDIQAGEEILINYNGDEDDQEL 119
Cdd:cd20073   175 INHSCDPNLAIYSVLRDKSDSkiydlaFFAIKDIPALEELTFDYSGRNNFDQL 227
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 17-111 5.08e-03

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 34.96  E-value: 5.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  17 GVFAKQDIKKGTLIHE--APVIAypnkEHDFiEKTTLADYAfeYGVNHTAILLGYGMLF------------NHSYTPNA- 81
Cdd:cd19174    13 GVRTKEPIKAGQFIIEyvGEVVS----EQEF-RRRMIEQYH--NHSHHYCLNLDSGMVIdgyrmgnearfvNHSCDPNCe 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1266074341  82 --TYEINfDNHTFDFYAYTDIQAGEEILINYN 111
Cdd:cd19174    86 mqKWSVN-GVYRIGLFALKDIPAGEELTYDYN 116
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 17-117 8.14e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 34.33  E-value: 8.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266074341  17 GVFAKQDIKKGTLiheapVIAY---------PNKEHDFIEKTTLADYAF----EYGVNHTaILLGYGMLFNHSYTPNATY 83
Cdd:cd19171    27 GLYAARDIEKHTM-----VIEYigeiirnevANRREKIYESQNRGIYMFridnDWVIDAT-MTGGPARYINHSCNPNCVA 100

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1266074341  84 EI-NFDN-HTFDFYAYTDIQAGEEILINYNGD-EDDQ 117
Cdd:cd19171   101 EVvTFDKeKKIIIISNRRIAKGEELTYDYKFDfEDDQ 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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