NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1266160895|gb|PHA56178|]
View 

VOC family protein [Bacillus wiedmannii]

Protein Classification

VOC family protein( domain architecture ID 10163559)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms; similar to type I extradiol dioxygenase, glyoxalase I and a group of antibiotic resistance proteins such as Staphylococcus aureus bleomycin resistance protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VOC_like cd07263
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 7-124 3.73e-48

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


:

Pssm-ID: 319924 [Multi-domain]  Cd Length: 120  Bit Score: 150.14  E-value: 3.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   7 QIMLYVNNQDEAVQFWTETVGFQIIAEENNGqGFRWIEIAPTKEAGTSIVLHDKALIAKM--QPELNLNTPSLMFFSNNL 84
Cdd:cd07263     1 QVMLYVDDQDKALDFYVEKLGFEVVEDVPMG-GMRWVTVAPPGSPGTSLLLEPKAHPAQMpqSPEAAGGTPGILLATDDI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1266160895  85 DQLYKDLSEKNVTVGQ-VVDLPTGRAFNFADNENNYFAVME 124
Cdd:cd07263    80 DATYERLTAAGVTFVQePTQMGGGRVANFRDPDGNLFALME 120
 
Name Accession Description Interval E-value
VOC_like cd07263
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 7-124 3.73e-48

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


Pssm-ID: 319924 [Multi-domain]  Cd Length: 120  Bit Score: 150.14  E-value: 3.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   7 QIMLYVNNQDEAVQFWTETVGFQIIAEENNGqGFRWIEIAPTKEAGTSIVLHDKALIAKM--QPELNLNTPSLMFFSNNL 84
Cdd:cd07263     1 QVMLYVDDQDKALDFYVEKLGFEVVEDVPMG-GMRWVTVAPPGSPGTSLLLEPKAHPAQMpqSPEAAGGTPGILLATDDI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1266160895  85 DQLYKDLSEKNVTVGQ-VVDLPTGRAFNFADNENNYFAVME 124
Cdd:cd07263    80 DATYERLTAAGVTFVQePTQMGGGRVANFRDPDGNLFALME 120
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-126 1.06e-11

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 57.34  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   1 MINQIGQIMLYVNNQDEAVQFWTETVGFQIIAEENNGQGFRWIEIAPTKEAGtsivlhdkalIAKMQPELNLNTPSLMFF 80
Cdd:COG3324     1 MPGTIVWVELPVDDLERAKAFYEEVFGWTFEDDAGPGGDYAEFDTDGGQVGG----------LMPGAEEPGGPGWLLYFA 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1266160895  81 SNNLDQLYKDLSEKNVTV-GQVVDLP-TGRAFNFADNENNYFAVMEKK 126
Cdd:COG3324    71 VDDLDAAVARVEAAGGTVlRPPTDIPpWGRFAVFRDPEGNRFGLWQPA 118
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
4-114 4.51e-10

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 53.22  E-value: 4.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   4 QIGQIMLYVNNQDEAVQFWTETVGFQIIAEENNGQGFRWIEIAPTkEAGTSIVLHDKALIAKMQPELNLNTPSLMFFS-N 82
Cdd:pfam00903   1 RIDHVALRVGDLEKSLDFYTDVLGFKLVEETDAGEEGGLRSAFFL-AGGRVLELLLNETPPPAAAGFGGHHIAFIAFSvD 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1266160895  83 NLDQLYKDLSEKNVTVGQVVD--LPTGRAFNFAD 114
Cdd:pfam00903  80 DVDAAYDRLKAAGVEIVREPGrhGWGGRYSYFRD 113
 
Name Accession Description Interval E-value
VOC_like cd07263
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 7-124 3.73e-48

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


Pssm-ID: 319924 [Multi-domain]  Cd Length: 120  Bit Score: 150.14  E-value: 3.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   7 QIMLYVNNQDEAVQFWTETVGFQIIAEENNGqGFRWIEIAPTKEAGTSIVLHDKALIAKM--QPELNLNTPSLMFFSNNL 84
Cdd:cd07263     1 QVMLYVDDQDKALDFYVEKLGFEVVEDVPMG-GMRWVTVAPPGSPGTSLLLEPKAHPAQMpqSPEAAGGTPGILLATDDI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1266160895  85 DQLYKDLSEKNVTVGQ-VVDLPTGRAFNFADNENNYFAVME 124
Cdd:cd07263    80 DATYERLTAAGVTFVQePTQMGGGRVANFRDPDGNLFALME 120
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-126 1.06e-11

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 57.34  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   1 MINQIGQIMLYVNNQDEAVQFWTETVGFQIIAEENNGQGFRWIEIAPTKEAGtsivlhdkalIAKMQPELNLNTPSLMFF 80
Cdd:COG3324     1 MPGTIVWVELPVDDLERAKAFYEEVFGWTFEDDAGPGGDYAEFDTDGGQVGG----------LMPGAEEPGGPGWLLYFA 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1266160895  81 SNNLDQLYKDLSEKNVTV-GQVVDLP-TGRAFNFADNENNYFAVMEKK 126
Cdd:COG3324    71 VDDLDAAVARVEAAGGTVlRPPTDIPpWGRFAVFRDPEGNRFGLWQPA 118
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
4-114 4.51e-10

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 53.22  E-value: 4.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   4 QIGQIMLYVNNQDEAVQFWTETVGFQIIAEENNGQGFRWIEIAPTkEAGTSIVLHDKALIAKMQPELNLNTPSLMFFS-N 82
Cdd:pfam00903   1 RIDHVALRVGDLEKSLDFYTDVLGFKLVEETDAGEEGGLRSAFFL-AGGRVLELLLNETPPPAAAGFGGHHIAFIAFSvD 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1266160895  83 NLDQLYKDLSEKNVTVGQVVD--LPTGRAFNFAD 114
Cdd:pfam00903  80 DVDAAYDRLKAAGVEIVREPGrhGWGGRYSYFRD 113
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 5-126 8.27e-10

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 52.69  E-value: 8.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   5 IGQIMLYVNNQDEAVQFWTETVGFQIIAEENNGQG---FRWIEIAptkeAGTSIVLHDKALIAKMQPELNLNTpsLMFFS 81
Cdd:COG0346     3 LHHVTLRVSDLEASLAFYTDVLGLELVKRTDFGDGgfgHAFLRLG----DGTELELFEAPGAAPAPGGGGLHH--LAFRV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1266160895  82 NNLDQLYKDLSEKNVTV-GQVVDLPTG-RAFNFADNENNYFAVMEKK 126
Cdd:COG0346    77 DDLDAAYARLRAAGVEIeGEPRDRAYGyRSAYFRDPDGNLIELVEPP 123
CatE COG2514
Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];
2-118 2.70e-07

Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442004 [Multi-domain]  Cd Length: 141  Bit Score: 46.10  E-value: 2.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   2 INQIGQIMLYVNNQDEAVQFWTETVGFQIIAEENNGQGFRwieiapTKEAGTSIVLHDKALIAKMQPELNLN-----TPS 76
Cdd:COG2514     1 ITRLGHVTLRVRDLERSAAFYTDVLGLEVVEREGGRVYLR------ADGGEHLLVLEEAPGAPPRPGAAGLDhvafrVPS 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1266160895  77 LmffsNNLDQLYKDLSEKNVTVGQVVDLPTGRAFNFADNENN 118
Cdd:COG2514    75 R----ADLDAALARLAAAGVPVEGAVDHGVGESLYFRDPDGN 112
VOC_like cd07264
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 5-119 2.74e-03

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319925 [Multi-domain]  Cd Length: 118  Bit Score: 35.00  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266160895   5 IGQIMLYVNNQDEAVQFWTETVGFQIIAEENNGQgfrWIEIaptKEAGTSIVLHDKALIAKMQPELNLNTPSLMFFS-NN 83
Cdd:cd07264     1 IAYIVLYVDDFAASLRFYRDVLGLPPRFLHEEGE---YAEF---DTGETKLALFSRKEMARSGGPDRRGSAFELGFEvDD 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1266160895  84 LDQLYKDLSEKNVTVGQVVDLPT--GRAFNFADNENNY 119
Cdd:cd07264    75 VEATVEELVERGAEFVREPANKPwgQTVAYVRDPDGNL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH