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Conserved domains on  [gi|1266267306|gb|PHB59524|]
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MarR family transcriptional regulator [Bacillus toyonensis]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-131 1.66e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.79  E-value: 1.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266267306   2 EELSTNVFAMFRTLRNDIGKIFGGY-IPWNEFIVLRILNRTNKEMVSRVANELNVSNSHITAVTEKLINKGFVTRSRSTS 80
Cdd:COG1846    10 ERLGLLLRRLARALRRALDRALAELgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1266267306  81 DRRVVYLEITEQGKDLVAKMEEAKKRYLQERFSALSEDEMNVMISISQKLI 131
Cdd:COG1846    90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-131 1.66e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.79  E-value: 1.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266267306   2 EELSTNVFAMFRTLRNDIGKIFGGY-IPWNEFIVLRILNRTNKEMVSRVANELNVSNSHITAVTEKLINKGFVTRSRSTS 80
Cdd:COG1846    10 ERLGLLLRRLARALRRALDRALAELgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1266267306  81 DRRVVYLEITEQGKDLVAKMEEAKKRYLQERFSALSEDEMNVMISISQKLI 131
Cdd:COG1846    90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
29-120 8.97e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 80.33  E-value: 8.97e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266267306   29 WNEFIVLRILNRTNKEMVSRVANELNVSNSHITAVTEKLINKGFVTRSRSTSDRRVVYLEITEQGKDLVAKMEEAKKRYL 108
Cdd:smart00347  10 PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSETL 89

                           90
                   ....*....|..
gi 1266267306  109 QERFSALSEDEM 120
Cdd:smart00347  90 AELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-85 8.07e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 48.31  E-value: 8.07e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1266267306  27 IPWNEFIVLRILNRTNKEMVSRVANELNVSNSHITAVTEKLINKGFVTRSRSTSDRRVV 85
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 47-131 3.07e-06

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 43.97  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266267306  47 SRVANELNVSNSHITAVTEKLINKGFVTRSRSTSDRRVVYLEITEQGKDLVAKMEEAKKRYLQERFSALSEDEMNVMISI 126
Cdd:PRK10870   75 SELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQI 154


                  ....*
gi 1266267306 127 SQKLI 131
Cdd:PRK10870  155 TRKLL 159
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-131 1.66e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.79  E-value: 1.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266267306   2 EELSTNVFAMFRTLRNDIGKIFGGY-IPWNEFIVLRILNRTNKEMVSRVANELNVSNSHITAVTEKLINKGFVTRSRSTS 80
Cdd:COG1846    10 ERLGLLLRRLARALRRALDRALAELgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1266267306  81 DRRVVYLEITEQGKDLVAKMEEAKKRYLQERFSALSEDEMNVMISISQKLI 131
Cdd:COG1846    90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
29-120 8.97e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 80.33  E-value: 8.97e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266267306   29 WNEFIVLRILNRTNKEMVSRVANELNVSNSHITAVTEKLINKGFVTRSRSTSDRRVVYLEITEQGKDLVAKMEEAKKRYL 108
Cdd:smart00347  10 PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSETL 89

                           90
                   ....*....|..
gi 1266267306  109 QERFSALSEDEM 120
Cdd:smart00347  90 AELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-85 8.07e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 48.31  E-value: 8.07e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1266267306  27 IPWNEFIVLRILNRTNKEMVSRVANELNVSNSHITAVTEKLINKGFVTRSRSTSDRRVV 85
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_27 pfam13463
Winged helix DNA-binding domain;
30-93 1.03e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 45.74  E-value: 1.03e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1266267306  30 NEFIVLRILNRTNKEMV-SRVANELNVSNSHITAVTEKLINKGFVTRSRSTSDRRVVYLEITEQG 93
Cdd:pfam13463   4 LEALILHNIGHRGDPKTlADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 47-131 3.07e-06

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 43.97  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266267306  47 SRVANELNVSNSHITAVTEKLINKGFVTRSRSTSDRRVVYLEITEQGKDLVAKMEEAKKRYLQERFSALSEDEMNVMISI 126
Cdd:PRK10870   75 SELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQI 154


                  ....*
gi 1266267306 127 SQKLI 131
Cdd:PRK10870  155 TRKLL 159
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 65-130 4.76e-05

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 40.37  E-value: 4.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1266267306  65 EKLINKGFVTRSRSTSDRRVVYLEITEQGKDLVAKMEEAKKRYLQERFSALSEDEMNVMISISQKL 130
Cdd:PRK03573   68 DQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQLITLIAKL 133
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-83 1.01e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 1.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1266267306  31 EFIVLRILNRTNKEMVSRVANELNVSNSHITAVTEKLINKGFVTRSRSTSDRR 83
Cdd:pfam12802   7 QFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
PRK13777 PRK13777
HTH-type transcriptional regulator Hpr;
30-103 1.57e-03

HTH-type transcriptional regulator Hpr;


Pssm-ID: 237501  Cd Length: 185  Bit Score: 36.56  E-value: 1.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1266267306  30 NEFIVLRILNRTNKEMVSRVAN--ELNVSnshiTAV--TEKLINKGFVTRSRSTSDRRVVYLEITEQGKDLVAKMEEA 103
Cdd:PRK13777   46 NEHHILWIAYHLKGASISEIAKfgVMHVS----TAFnfSKKLEERGYLTFSKKEDDKRNTYIELTEKGEELLLETMEE 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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