|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
8-378 |
1.17e-71 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 229.04 E-value: 1.17e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 8 IRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFI 87
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 88 ALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQPAH-MRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTG 166
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPeNRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 167 SLMLLFAFIFYLLKNHFQVTTEN---TSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNI-SNSNQLATL 242
Cdd:cd17329 161 VLFLLAALVLLFLLPETRPKRRAaekTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEIlGLGESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 243 VITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNE 322
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1266290634 323 SYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYtPWLIFSGIGLIGFISLHIL 378
Cdd:cd17329 321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL-PWLILAALGLIAAALLLGL 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-378 |
2.56e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 119.60 E-value: 2.56e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 12 LISSFFMSFGYFAVYAFLAIYLLTfLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGI 91
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 92 CSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLML 170
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIaPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 171 LFAFIFYLL------KNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISN-SNQLATLV 243
Cdd:cd17325 161 LLALVLALLllpeprPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 244 ITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNES 323
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1266290634 324 YTATYFGFYQLSLAFGFIIGNYTGtSFTSNLNGMYTPWLIFSGIGLIGFISLHIL 378
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLG-GFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
10-378 |
7.60e-30 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 119.01 E-value: 7.60e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 10 FMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIAL 89
Cdd:PRK11646 14 FLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATM 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 90 GICSDFYTISISSALIGFGTAFYEP--AARAIFGSQPaHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGS 167
Cdd:PRK11646 94 AIAHEPWLLWLSCILSGLGGTLFDPprTALVIKLIRP-HQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 168 LMLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITIN 247
Cdd:PRK11646 173 LFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPSAVKWMYAIE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 248 AITGVIFMVLFRKLFHKYNTLSI-IKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTA 326
Cdd:PRK11646 253 ACLSLTLLYPIARWSEKRFRLEHrLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARETLSASLADARARG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1266290634 327 TYFGFYQLSLAFGFIIGnYTGTSFTSNL-NGMYTPWLIFSGIGLIGFISLHIL 378
Cdd:PRK11646 333 SYMGFSRLGLALGGAIG-YIGGGWLFDLgKALNQPELPWMMLGIIGLITLLAL 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-339 |
4.28e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.84 E-value: 4.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 6 IPIRFMLISSFFMSFGYFAVYAFLAIYLLTFlHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIG 85
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 86 FIALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFL 164
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLvPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 165 TGSLMLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISN-SNQLATLV 243
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 244 ITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNES 323
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328
|
330
....*....|....*.
gi 1266290634 324 YTATYFGFYQLSLAFG 339
Cdd:COG2814 329 ARGRASGLYNSAFFLG 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-343 |
4.53e-21 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 94.58 E-value: 4.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 15 SFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIG-----YIIMMIAGLFLRGIGFIAL 89
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 90 GICSDFYTIS------ISSALIGFGTAFYEPAARAIFG--SQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLL---DS 158
Cdd:COG2211 99 FTAPDLSPTGkliyalVTYLLLGLAYTLVNIPYSALGAelTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggDA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 159 IYAFFLTGSLMLLFAFIFYLL-----KNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMK-N 232
Cdd:COG2211 179 ALGYRLTALIFAVLGLLAFLLtffgtKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKyV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 233 ISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQ--HPYWLFICVILFTIGETLVLP 310
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILV 338
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1266290634 311 NADIAIAN-------YSNESYTATYFGFYQLSLAFGFIIG 343
Cdd:COG2211 339 LPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALA 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-343 |
1.98e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.33 E-value: 1.98e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 11 MLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALG 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 91 ICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLM 169
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWfPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 170 LLFAFIFYLL-------KNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTqLTVALPLHMKNISNSNQLATL 242
Cdd:pfam07690 161 SLLAAVLLLLprpppesKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-LLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 243 VITINAITGVIFMVLFRKLFHKYN---TLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANY 319
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGrrrRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....
gi 1266290634 320 SNESYTATYFGFYQLSLAFGFIIG 343
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
36-378 |
2.08e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 91.86 E-value: 2.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 36 FLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPA 115
Cdd:cd17474 28 ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 116 ARAIFGS-QPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLMLLFAFIFYLLKNHFQVTTENTSIT- 193
Cdd:cd17474 108 ALTLIGDlFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATk 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 194 -LGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKN-ISNSNQLATLVITINAITGVIF-MVLFRKLFHKYNTLSI 270
Cdd:cd17474 188 lRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELlYGISPIIIGLLFAGWSVLLALGsLFVGRLLKKRFGARRI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 271 IKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGtSF 350
Cdd:cd17474 268 LVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLF-GL 346
|
330 340
....*....|....*....|....*...
gi 1266290634 351 TSNLNGMYTPWLIFSGIGLIGFISLHIL 378
Cdd:cd17474 347 LLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-343 |
3.01e-20 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 91.12 E-value: 3.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 11 MLISSFFMSFGYFAVYAFLAIYLLTfLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALG 90
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 91 ICSDFYTISISSALIGFGTAFYEPAARAIFGSQ--PAHMRKNLFtYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSL 168
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIipPSRRGEGIG-YYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 169 MLLFAFIF-YLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNqlATLVITIN 247
Cdd:cd17489 159 LALLALLLvFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN--AGLFFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 248 AITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNES---- 323
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHrrga 316
|
330 340
....*....|....*....|
gi 1266290634 324 YTATYFGFYQLSLAFGFIIG 343
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLL 336
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-375 |
2.28e-19 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 88.78 E-value: 2.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 40 SAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAARAI 119
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 120 FGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLMLLFAFIFYLLKNHFQVTTENTSITLGIQA 198
Cdd:cd17473 113 IGDYfEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 199 ILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNI-SNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILL 277
Cdd:cd17473 193 ALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERgGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 278 MGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGM 357
Cdd:cd17473 273 MALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGL 352
|
330
....*....|....*...
gi 1266290634 358 YTPWLIFSGIGLIGFISL 375
Cdd:cd17473 353 SGAFLILGVLALVLAIVL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
32-301 |
1.11e-17 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 83.76 E-value: 1.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 32 YLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAF 111
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 112 YEPAARAIFgSQPAHMRKNLFTYLNLSF-NCGAIIGPIAGGFLLLLDSIYAFFLTGSLMLLFAFIFYLLKN---HFQVTT 187
Cdd:cd17478 101 FHPEGARLA-SQAAGGRRGLAMSIFSVGgNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRplkKPEAKK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 188 ENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNT 267
Cdd:cd17478 180 AAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGR 259
|
250 260 270
....*....|....*....|....*....|....
gi 1266290634 268 LSIIKYGILLMGISFLLIPLFQhPYWLFICVILF 301
Cdd:cd17478 260 RRVIIASLLLAAPFLLLFLLTP-GIWSYILLVLA 292
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-180 |
1.85e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.01 E-value: 1.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 7 PIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGF 86
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 87 IALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLL-LLDSIYAFFL 164
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIvPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLA 359
|
170
....*....|....*.
gi 1266290634 165 TGSLMLLFAFIFYLLK 180
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-376 |
7.28e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 81.32 E-value: 7.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 12 LISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGI 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 92 CSDFYTISISSALIGFGTAFYEPAA-RAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSI---YAFFLTGS 167
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 168 LMLLFAFIFYLLKNHFQ-------VTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISN-SNQL 239
Cdd:cd06174 161 LALLAAILLLLVVPDPPesaraknEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 240 ATLVITINAITGVIFMVLFRKLFHKY-NTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIAN 318
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1266290634 319 YSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYTPWLIFSGIGLIGFISLH 376
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
16-373 |
1.16e-16 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 81.08 E-value: 1.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 16 FFMSFGYFAVYAFLAIYLLT--FLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKI-GYIIMMIAGLFLRGIGFIALGIC 92
Cdd:cd17346 12 MWERFSYYGMRAILILYLTAqlGDGFSEADAASIYGAYTALVYLTPIIGGWLADKVlGARRTVFIGGILMALGYLLLALS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 93 S-DFYTISISSALIGFGTAFYEPAARAIFG---SQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFL-LLLDSIYAFFLTGS 167
Cdd:cd17346 92 PfSVSMLYLGLALIIVGNGLFKPNISSLVGklyDENDPRRDSGFSIFYMGINLGAFLAPLLCGTLgDNYGYHYGFGLAAV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 168 LMLLFAFIFYLLKNHFQVttentsitlgiqaILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVIT-- 245
Cdd:cd17346 172 GMLLGLLIFLLGRKKLLE-------------RKKMLAIIILFLFAVVFWAIYEQAGTSLALFADENVDRLLGGFTIPPsw 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 246 ---INA----ITGVIFMVLFRKLFHKYNTLSIIK---YGILLMGISFLLIPLF---------QHPYWLFICVILFTIGET 306
Cdd:cd17346 239 fqsLNPlfiiLLAPILAALWTKLGKRGKDPSIPTkfaLGLLLLGLSFLLMVLAasfaggsgkVSALWLVLSYFLQTLGEL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 307 LVLPNADIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYT---PWLIFSGIGLIGFI 373
Cdd:cd17346 319 CLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFYAQPKDPLASalvYTDYFGLIGVIALV 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-381 |
1.30e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 80.30 E-value: 1.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 8 IRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFI 87
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 88 ALGICSDFYTISISSALIGFGTAFYEPAA-RAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSI-YAFFLT 165
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAAlKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWrAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 166 GSLMLLFAFIfyllknhfqvttentsitlgiqailqnkPFLLFSFIMIFFYIMFTQLTVALPLHMKNISN-SNQLATLVI 244
Cdd:COG2271 171 GLPGLLLALL----------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 245 TINAITGVIFMVLF----RKLFHKYNTLSIIkyGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYS 320
Cdd:COG2271 223 SLPFLAGIVGSLLGgwlsDRLGRRRKLVLAI--GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1266290634 321 NESYTATYFGFYQLSLAFGFIIGNYtGTSFTSNLNGMYTPWLIFSGIGLIGFISLHILNIK 381
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPL-LVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-301 |
1.40e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 80.67 E-value: 1.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 1 MKSFSIPIRFMLISSFFMSFG-YFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGL 79
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGfATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 80 FLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLD-- 157
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 158 ----SIYAFFLTGSLMLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFsFIMIFFYiMFTQLTVA--LPLHMK 231
Cdd:COG0738 161 lswhLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLG-GLAIFLY-VGAEGAIGdwLPLYLK 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1266290634 232 NISN-SNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILF 301
Cdd:COG0738 239 DVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-375 |
1.30e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 74.57 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 9 RFMLISSFFMSFGyFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIA 88
Cdd:cd06173 2 RLLWLAQLLSALG-DWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 89 LGICSDFYTIS-----ISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAF 162
Cdd:cd06173 81 LALLALLGSLSlwlllVLAFLLGIASAFFGPARQALLPELvPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 163 FLTGSLMLLFAFIFYLL-------KNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISN 235
Cdd:cd06173 161 FAINALSFLLSALLLLFirrpppaAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 236 -SNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADI 314
Cdd:cd06173 241 gGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1266290634 315 AIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYTPWLIFSGIGLIGFISL 375
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-378 |
4.73e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.99 E-value: 4.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 10 FMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIAL 89
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 90 GICSDFYTISISSALIGFGT-AFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSI-YAFFLTGS 167
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWrNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 168 LMLLFAFIFYLLKNH--FQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNI-SNSNQLATLVI 244
Cdd:COG2223 168 LLLVVAVLAWLFLRDppAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 245 TINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFI-CVILFTIGETLVLPNADIAIANYSNES 323
Cdd:COG2223 248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDIFPTK 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1266290634 324 YTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYTPWLIFSGIGLIGFISLHIL 378
Cdd:COG2223 328 NAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
13-344 |
7.62e-14 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 72.19 E-value: 7.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 13 ISSFFMSFGYFAVYAFLAIYLlTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIG-YIIMMIAGLFLRGIGFIALGI 91
Cdd:cd17370 6 LVSLFADISYEMARSILPLFL-VVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 92 CSDFYTISISSALIGFGTAFYEPAARAIFG-SQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSI---YAFFLTGS 167
Cdd:cd17370 85 AGSWQLVLLLRILERLGKGIRTPPRDALLAdATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyrTIFLLAAI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 168 LMLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFyiMFTQLTVALP-LHMKNISNSNQLATLVITI 246
Cdd:cd17370 165 PALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALF--ALGNFSFAFLiLRAQELGLSAALIPLLYAL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 247 NAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTA 326
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
|
330
....*....|....*...
gi 1266290634 327 TYFGFYQLSLAFGFIIGN 344
Cdd:cd17370 323 TAYGLFNTVVGIGWLLAS 340
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
11-375 |
1.45e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 67.99 E-value: 1.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 11 MLISSFFMSFGYFAVYAFLAIYLLTFLHFSAV--QVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIA 88
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 89 LGICSDFYTISISSALIGFGTAFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSL 168
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 169 MLLFAFIFyllknhfqvttentsitlgIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINA 248
Cdd:cd17330 161 LALLNLVL-------------------VLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 249 ITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATY 328
Cdd:cd17330 222 AGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1266290634 329 FGFYQLSLAFGFIIGNYTGTSFTSNLNGmYTPWLIFSGIGLIGFISL 375
Cdd:cd17330 302 QGIIQSLQSLARIIGPLLAGPLYSFLGP-GVPFLLAAGLLLIALFLL 347
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-180 |
8.10e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.10 E-value: 8.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 5 SIPIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGI 84
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 85 GFIALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFF 163
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRvPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 1266290634 164 LTGSLMLLFAFIFYLLK 180
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
12-300 |
2.28e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 64.49 E-value: 2.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 12 LISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIG-YIIMMIAGLFLRGIGFIALG 90
Cdd:cd17471 2 LLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 91 ICSDFYTISISSALIGFGTAFYEPA----ARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFL-T 165
Cdd:cd17471 82 FLRNYWVLLLVGVVLLSLGAAAFPQlfalAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLlA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 166 GSLMLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKN-ISNSNQLATLVI 244
Cdd:cd17471 162 ALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNeLGGSESWVGLLF 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1266290634 245 TINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVIL 300
Cdd:cd17471 242 GLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLL 297
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-373 |
8.31e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 63.05 E-value: 8.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 11 MLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQV----GTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGF 86
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 87 IALGICSDFYTISISSALIGFGTAFYePAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLL-LLDSIYAFFL 164
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQtPKEKSGWALGTLSTGVVAGTLIGPLLGGFLAdLFGIRNVFFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 165 TGSLMLL--FAFIFYLLKNHFQVTTENTSITLGIQAILQNKPfLLFSFIMIFFYIMFTQLTVA--LPLH----MKNISNS 236
Cdd:cd17391 160 TGGLLFLafLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPS-LLISLFVTTFIIQLANQSIEpiLTLYirqlMGDASNL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 237 NQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAI 316
Cdd:cd17391 239 AFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLL 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1266290634 317 ANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLnGMYTPWLIFSGIGLIGFI 373
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHF-GYRAVFVVTALLVLLNAI 374
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
20-374 |
1.12e-10 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 62.91 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 20 FGYFAVYAFLAIYL-----LTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADK-IGYIIMMIAGLFLRGIGFIALGICS 93
Cdd:COG3104 28 FSFYGMRAILVLYLtaslaDGGLGLSEADAAAIYGAYTALVYLTPLLGGWLADRlLGQRRAILLGGILMALGHFLLALPG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 94 DFYTISISSALIGFGTAFYEPAARAIFG---SQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSI-YAFFLTGSLM 169
Cdd:COG3104 108 GVTLFYLGLALIAVGNGLFKPNISSLVGqlyDPGDPRRDAGFTIFYMGINIGAFLAPLLCGYLGEKYGWhYGFGAAAIGM 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 170 LLFAFIFYLLKNHF-----------------------------------------QVTTENTSITLGIQAILQNKP---- 204
Cdd:COG3104 188 LIGLIIFLLGRKYLgdiglepdnplskkerliavalgalllvlvlagllsnaniaNYLLYVIAIIAYFIFILRSKKltke 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 205 -------FLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQL-----ATLVITINA----ITGVIFMVLFRKLFHKYNTL 268
Cdd:COG3104 268 erkrllaILILFLFSIVFWALYEQAGTSLNLFADRNVDRSLFgfeipPSWFQSLNPlfiiILAPVFAALWTKLGKRGKEP 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 269 SIIK---YGILLMGISFLLIPLFQ---------HPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGFYQLSL 336
Cdd:COG3104 348 STPTkfaLGLLLLGLGFLVMALAAllagaggkvSPLWLVLAYLLLTIGELCLSPVGLSMITKLAPARFAGQMMGLWFLAT 427
|
410 420 430
....*....|....*....|....*....|....*...
gi 1266290634 337 AFGFIIGnytgtSFTSNLNGMYTPWLIFSGIGLIGFIS 374
Cdd:COG3104 428 ALGNLLA-----GLLAGLYAVPGYTAYFLLLGGIALVA 460
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
20-375 |
6.07e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 60.31 E-value: 6.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 20 FGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTIS 99
Cdd:cd17472 10 LGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 100 ISSALIGFGtAFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLMLLFAFI--FY 177
Cdd:cd17472 90 LGRALQGSG-AISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLilLF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 178 LLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINAITGVIFMVL 257
Cdd:cd17472 169 FVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 258 FRKLFHKYNTLS-IIKYGILLMGISFL-LIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGFYQLS 335
Cdd:cd17472 249 FVIYAEKKGKMKqVFVSSILLIAVGFLlLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTS 328
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1266290634 336 LAFGFIIGNYTGTSFTSNLNGMYTPWLIFSGIGLIGFISL 375
Cdd:cd17472 329 QFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSF 368
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
37-375 |
1.65e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.10 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 37 LHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAA 116
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 117 RAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFL-LLLDSIYAFFLTGSLMLLFAFIFYLLKNHFQVTTENTSITL 194
Cdd:cd17324 109 AAYAADLvPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLgQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 195 GIQAILQNKPFLLFSFIMIFFYI--MFTQLTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIK 272
Cdd:cd17324 189 SSLLLLLRNPRLRLAYLITFLLFggFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 273 YGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESyTATYFGFYQLSLAFGFIIGNYTGTSFTS 352
Cdd:cd17324 269 ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLD 347
|
330 340
....*....|....*....|...
gi 1266290634 353 NLNGMYTPWLIFSGIGLIGFISL 375
Cdd:cd17324 348 HGGWAGVGWVGAALLLLALLLAL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-179 |
1.89e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.73 E-value: 1.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 6 IPIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIG--YIIMMIAGLFLRG 83
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 84 IGFIALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAF 162
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELfPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170
....*....|....*..
gi 1266290634 163 FLTGSLMLLFAFIFYLL 179
Cdd:COG2271 340 FLLLAALALLAALLALL 356
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
7-176 |
4.59e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.59 E-value: 4.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 7 PIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLF-SGLIADKIGYIIMMIAGLFLRGIG 85
Cdd:cd17330 175 PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 86 FIALGICSDFYTISISSALIGFGTAFYEPAARAIF-GSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFL 164
Cdd:cd17330 255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLsKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFL 334
|
170
....*....|..
gi 1266290634 165 TGSLMLLFAFIF 176
Cdd:cd17330 335 LAAGLLLIALFL 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
1-178 |
6.93e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.17 E-value: 6.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 1 MKSFSIPIRFMLISSFFMSFGYFAvYAFLAIYLLTfLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLF 80
Cdd:cd17370 195 LKKLPKAFWLYLLAVALFALGNFS-FAFLILRAQE-LGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 81 LRGIGFIALGICSDFYTISISSALIGFGTAFYEPAARA-IFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSI 159
Cdd:cd17370 273 SLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAaVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISP 352
|
170
....*....|....*....
gi 1266290634 160 YAFFLTGSLMLLFAFIFYL 178
Cdd:cd17370 353 SAAFLFSAVLALIALLLLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
16-180 |
9.62e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.45 E-value: 9.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 16 FFMSFGYFAVYAFLAIYLLTFLHfsaVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDF 95
Cdd:cd17489 204 FLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 96 YTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLMLLFAF 174
Cdd:cd17489 281 WMLLLAAVLYGLGFGLLFPALQALAVDLvPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLAL 360
|
....*.
gi 1266290634 175 IFYLLK 180
Cdd:cd17489 361 VLYIFL 366
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
11-339 |
1.41e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 56.04 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 11 MLISSFFMSFGYFAVYAFLAI--YLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIA 88
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPAlpAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 89 LGICSDFYTISISSALIGFGTAFYEPAARAIF-GSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLL---DSIYAFFL 164
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFfgwRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 165 TGSLMLLFAFIFYLLKNHFQVTTENTSITLGIQ--AILQNKPFLLFSFIMIFFY-IMFTQLTVALPLHMKNISNSNQLAT 241
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAykRVLKNRRFLGYALALGLSFaGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 242 LVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQH-----PYWLFICVILFTIGETLVLPNAD-IA 315
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALlgglsLWPLVAPLFLIFFGFGLIFPNATsLA 320
|
330 340
....*....|....*....|....*
gi 1266290634 316 IANYSNESYTAT-YFGFYQLSLAFG 339
Cdd:cd17320 321 LEPFPHVAGTASaLLGFLQFLIGAL 345
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
37-318 |
1.91e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 55.64 E-value: 1.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 37 LHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAA 116
Cdd:cd17321 26 LGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPAS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 117 RAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLlldsiyAFFLTGSLMLLFAFIfyllknhfqvttentsitlG 195
Cdd:cd17321 106 LALIAATfPGERRGRALGLWGAVVGIGAALGPLLGGLLL------ELFGWRWIFLINVPI-------------------G 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 196 IQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLAT-LVITINAITGVIFMVLFRKLFHKYNTLSIIKYG 274
Cdd:cd17321 161 LVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAgLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1266290634 275 ILLMGISFLLIPLFQHPYW---LFICVILFTIGETLVL-PNADIAIAN 318
Cdd:cd17321 241 LLLTAVGLLLLALLGADSSvwlLLPGLVLLGLGLGLFAtPLTNAALSS 288
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
4-116 |
3.21e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.87 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 4 FSIPIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRG 83
Cdd:cd17321 166 LARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTA 245
|
90 100 110
....*....|....*....|....*....|....*.
gi 1266290634 84 IGFIALGIC---SDFYTISISSALIGFGTAFYEPAA 116
Cdd:cd17321 246 VGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPL 281
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
7-179 |
3.53e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 3.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 7 PIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSG-LIADKIGYIIMMIAGLFLRGIG 85
Cdd:cd17474 199 GLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALS 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 86 FIALGICSDFYTISISSALIGFGTAFYEPAARA-IFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFL 164
Cdd:cd17474 279 LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTlVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358
|
170
....*....|....*
gi 1266290634 165 TGSLMLLFAFIFYLL 179
Cdd:cd17474 359 VGAAIALAAAVLLAL 373
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
16-373 |
7.55e-08 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 54.16 E-value: 7.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 16 FFMSFGYFAVYAFLAIYL--LTFLHFSAVQV--GTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGI 91
Cdd:PRK09874 24 FLTGAAFSLVMPFLPLYVeqLGVTGHSALNMwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 92 CSDFYTISISSALIGFGTAFYePAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIY-AFFLTGS-L 168
Cdd:PRK09874 104 AQNIWQFLILRALLGLLGGFV-PNANALIATQvPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRpVFFITASvL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 169 MLLFAFIFYLLKNHFQVTTENTSITL-GIQAILQNkPFLLFSFIMIFFYIMFTQLTVA--LPLHMKNIS-NSNQLATLVI 244
Cdd:PRK09874 183 FLCFLVTLFCIRENFQPVSKKEMLHMrEVVTSLKN-PKLVLSLFVTTLIIQVATGSIApiLTLYVRELAgNVSNIAFISG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 245 TINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGIS-FLLIPL--FQHPYWLFICVILFTIGETLVLPNADIAIANYSN 321
Cdd:PRK09874 262 MIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSvLLLIPMsfVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSS 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1266290634 322 ESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLnGMYTPWLIFSGIGLIGFI 373
Cdd:PRK09874 342 NQIAGRIFSYNQSFRDIGNVTGPLMGAAISANY-GFRAVFLVTAGVVLFNAV 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
203-373 |
1.28e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.05 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 203 KPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISF 282
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 283 LLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLnGMYTPWL 362
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFL 168
|
170
....*....|.
gi 1266290634 363 IFSGIGLIGFI 373
Cdd:COG2814 169 VNAVLALLALL 179
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
12-179 |
1.63e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 12 LISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGI 91
Cdd:cd17473 203 YFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 92 CSDFYTISISSALIGFGTAFYEPAARA-IFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFL-LLLDSIYAFFLTGSLM 169
Cdd:cd17473 283 ASGLWVVLLGAILAGLGFGLLLPTLNSwAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLvNLTGGLSGAFLILGVL 362
|
170
....*....|
gi 1266290634 170 LLFAFIFYLL 179
Cdd:cd17473 363 ALVLAIVLLL 372
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-262 |
1.65e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 10 FMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIAL 89
Cdd:COG0477 17 LALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 90 GICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSL 168
Cdd:COG0477 97 GLAPSPELLIAARALQGIGAGGLMPGALALIAELfPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 169 MLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINA 248
Cdd:COG0477 177 LGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLAL 256
|
250
....*....|....
gi 1266290634 249 ITGVIFMVLFRKLF 262
Cdd:COG0477 257 LLLAALLLLLLLLL 270
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
12-343 |
4.07e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 4.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 12 LISSFFMSFGYFAVYAFLAIYLLTfLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIG-YIIMMIAGLFLRGIGFIALG 90
Cdd:cd17490 2 LIIVFLFWFSQYVYVPFLSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 91 ICSDFYTISISSALIGFGTAFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLML 170
Cdd:cd17490 81 LFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 171 LFAFIFYLLKNHFQVTTENTSITL-GIQAILQNKPFLLFSFI-MIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINA 248
Cdd:cd17490 161 VLGFILSLFIKEERREKKPVLTELkELLSVLKDKKLLFFSLLaILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 249 ITGVIFMVLFRKLFHKY-NTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPN-ADIAIANYSNESyTA 326
Cdd:cd17490 241 LPNALASLLSGTLFYKKlGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLlMSLSIEGVPAEQ-RS 319
|
330
....*....|....*..
gi 1266290634 327 TYFGFYQLSLAFGFIIG 343
Cdd:cd17490 320 TAMGFFQAIYALGMFLG 336
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
9-178 |
7.73e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 7.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 9 RFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIA 88
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 89 LGICSDFYTISISSALIGFGTAFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSL 168
Cdd:cd17324 281 TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAA 360
|
170
....*....|
gi 1266290634 169 MLLFAFIFYL 178
Cdd:cd17324 361 LLLLALLLAL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
9-378 |
1.01e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 50.26 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 9 RFMLISSFFMSFGYF--AVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGF 86
Cdd:cd17319 3 RIIPLLFLAYVINYLdrVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 87 IALGICSDFYTISISSALIGFGTA-FYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDS-IYAFFL 164
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAgFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGwRWAFII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 165 TGSLMLLFAFIFYLLKnhfqvttentsitlgiqailqnKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLAT-LV 243
Cdd:cd17319 163 EGLLGLLLAVLWWFYL----------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVgLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 244 ITINAITGVIFMVL---FRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYS 320
Cdd:cd17319 221 AAIPFLAGAIGMILggrLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1266290634 321 NESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYTPWLIFSGIGLIGFISLHIL 378
Cdd:cd17319 301 PGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
8-176 |
1.12e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 50.15 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 8 IRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFI 87
Cdd:COG2270 240 LLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 88 ALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGG-FLLLLDSIYAFFLT 165
Cdd:COG2270 320 AAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLiPPGREAEFFGLYALSGKAASFLGPLLFGlVTQLTGSQRLGILS 399
|
170
....*....|.
gi 1266290634 166 GSLMLLFAFIF 176
Cdd:COG2270 400 LIVFFVIGLVL 410
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-375 |
1.18e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.91 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 10 FMLISSFFMSFGYFAVYAFLAIYLLTFLHF--SAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFI 87
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSLglSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 88 ALGICSDFYTISISSALIGFGTAFYEPAARAIFG-SQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIY----AF 162
Cdd:cd17316 82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAeFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 163 FLTGSLMLLFAFIFYllknhfqvttentsitlgiqailqnKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISN-SNQLAT 241
Cdd:cd17316 162 FLIGALPALLALLLR-------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGlSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 242 LVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGIS--FLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANY 319
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILalPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1266290634 320 SNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYTPWLIFSGIGLIGFISL 375
Cdd:cd17316 297 FPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
7-154 |
1.77e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.90 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 7 PIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGF 86
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1266290634 87 IALGIC--SDFYTISISSALIGFGTAFYEPAARAIFG-SQPAHMRKN-------LFTYLNLSFNCGAIIGPIAGGFLL 154
Cdd:COG2211 309 LLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLAdVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
15-343 |
4.46e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 48.32 E-value: 4.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 15 SFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSD 94
Cdd:cd17352 11 VNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 95 FYTISIS-SALIGFGTAFYEPAARAIFGSQPAHmRKNLFTYLNLsfnCGAIIGPIAggFLLLLDSIYAFFLTGSLMLLFA 173
Cdd:cd17352 91 LWQLYLTyGVLGGLGLGLIYSPAIVIVGQYFEK-KRGLATGIAV---AGSGVGTFV--FPPLLRYLLDNYGWRGALLILG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 174 FIfyllknhfqvtTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINAITGVI 253
Cdd:cd17352 165 GL-----------CLNLCVCGLLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 254 FMVLFRKL--FHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGF 331
Cdd:cd17352 234 GRILLGLLadKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGL 313
|
330
....*....|..
gi 1266290634 332 YQLSLAFGFIIG 343
Cdd:cd17352 314 VLLFQGLAALVG 325
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
16-341 |
4.66e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.09 E-value: 4.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 16 FFMSFGYFAVYAFLAIYLLTF---LHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGIC 92
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLeeaFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 93 SDFYTISISSALIGFGTAFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLL--LLDSIYAFFLTGSLML 170
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLtsELSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 171 LFAFIFYLLK-----NHFQVTTENTSITLGIQAILQNKPFLLFS-FIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVI 244
Cdd:cd17333 162 LLAILILLTLfpelpSARNPQQSVGAFSASASRLLRNPSIILGAlALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 245 TINAITGVIFMVLF-----RKLFHKYntLSIIKYGILLMGISFLLIPLFQHPYWLFICV-----ILFTIGETLVLPNADI 314
Cdd:cd17333 242 SGFWVGITIGRLLGgpisrRIKPHTL--LVLSGSGALLGLLILLLAPTLVVGLVATALLglfmaALFPTILSLGISNLPY 319
|
330 340
....*....|....*....|....*..
gi 1266290634 315 AIANYSNESYTATYFGFYQLSLAFGFI 341
Cdd:cd17333 320 AKGKGTSVLLAAGSIGGAIIPFIMGFI 346
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
18-304 |
1.31e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.88 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 18 MSFGYFAVY------AFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGI 91
Cdd:cd17312 8 VFLGYAAYYvcrknfSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 92 CSDFYTISISSALIG-FGTAFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPI-AGGFLLLLDSIYAFFLTGSLM 169
Cdd:cd17312 88 STSLWFFAVLWGLNGlFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPIlAASLASYYGWRAAFLVPGIVG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 170 LLFAFIFYLLknhfqvttentsitlgiqaiLQNKPFLL--FSFIMIFFYIMFTQLTVALPLHMKNISNSNQL-ATLVITI 246
Cdd:cd17312 168 LVVAIILFFF--------------------LRDSPPYVwvLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIdAGWFSSL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1266290634 247 NA---ITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFIcVILFTIG 304
Cdd:cd17312 228 YEvggIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSI-VLLFLIG 287
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
16-379 |
1.43e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 46.81 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 16 FFMSFGYFAVYAFLAIYLlTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIG-YIIMMIAGLFLRGIGFIALGICSD 94
Cdd:cd17335 7 FFFFAALGSLLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 95 FYTISISsaLIGFGTAFYEPAARAIFGSQPAHMRKNLFTY------LNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSL 168
Cdd:cd17335 86 IFWLLLL--LVILGAFFSAPVVPLVDSITLQYLGEERERYgkqrlwGSIGFGIAALLVGILIDRSSTYKNYTIAFYVFAV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 169 MLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINA 248
Cdd:cd17335 164 LMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 249 ITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATY 328
Cdd:cd17335 244 VSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATA 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1266290634 329 FGFYQ-LSLAFGFIIGNYTGTSFTSNLnGMYTPWLIFSGIGLIGFISLHILN 379
Cdd:cd17335 324 QGLLQgLYFGLGGGLGSLIGGYLYEAF-GARTTFRFFAIAALAGLLAFFLIQ 374
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
37-301 |
1.53e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.80 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 37 LHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAA 116
Cdd:cd17503 26 LGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 117 RA-IFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLMLLFAFIFYLLknhfqvttentsITLG 195
Cdd:cd17503 106 QTiLLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL------------LDLR 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 196 iqaILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLAT-LVITINAITGVIFMVLFRKLFHKYNTLSIIKYG 274
Cdd:cd17503 174 ---LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESgLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250
|
250 260
....*....|....*....|....*....
gi 1266290634 275 ILLMGISFLLIPLFQH--PYWLFICVILF 301
Cdd:cd17503 251 LLLLALGTLLLAFLTPdtSLWLIILPLFI 279
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
208-373 |
1.67e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 208 FSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPL 287
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 288 FQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGtSFTSNLNGMYTPWLIFSGI 367
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG-GLLADALGYRAPFLVCAAL 159
|
....*.
gi 1266290634 368 GLIGFI 373
Cdd:cd17325 160 ALLALV 165
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-128 |
1.84e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 46.46 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 18 MSFGYFAVYAfLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYT 97
Cdd:cd17475 8 ASLVAQGIPA-LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV 86
|
90 100 110
....*....|....*....|....*....|..
gi 1266290634 98 ISISSALIGFGTAFYEPAA-RAIFGSQPAHMR 128
Cdd:cd17475 87 LLVLLFLVGAGYGSVQPGGgRAIMRWFPPRER 118
|
|
| PRK15462 |
PRK15462 |
dipeptide permease; |
20-187 |
1.87e-05 |
|
dipeptide permease;
Pssm-ID: 237971 [Multi-domain] Cd Length: 493 Bit Score: 46.48 E-value: 1.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 20 FGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKI-GYIIMMIAGLFLRGIGFIALG---ICSDF 95
Cdd:PRK15462 23 FSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVlGNRMAVMLGALLMAIGHVVLGaseIHPSF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 96 YTISISSALIGFGtaFYEPAARAIFGS--QPAHMRKNL-FTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLMLLF 172
Cdd:PRK15462 103 LYLSLAIIVCGYG--LFKSNVSCLLGElyEPTDPRRDGgFSLMYAAGNVGSIIAPIACGYAQEEYSWAMGFGLAAVGMIA 180
|
170
....*....|....*.
gi 1266290634 173 AFIFYLLKN-HFQVTT 187
Cdd:PRK15462 181 GLVIFLCGNrHFTHTR 196
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
37-304 |
2.76e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.02 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 37 LHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAA 116
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 117 RAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSI-YAFFLTGSLMLLFAFIFYLLKNHFQVTTENTSITLG 195
Cdd:COG2807 128 PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWrGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 196 IQAILQNKPFLLFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGI 275
Cdd:COG2807 208 LRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLL 287
|
250 260
....*....|....*....|....*....
gi 1266290634 276 LLMGISFLLIPLFQHPYWLFICVILFTIG 304
Cdd:COG2807 288 GLLGLAGLLGLLLAPGSLPWLWAVLLGLG 316
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
20-179 |
5.38e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.06 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 20 FGYFAVY------AFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICS 93
Cdd:TIGR00881 2 IGYAAYYlvrknfALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 94 DFYTISISSALIGFGTAF-YEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGP--IAGGFLLLLDSIYAFFLTGSLML 170
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMgWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIAI 161
|
....*....
gi 1266290634 171 LFAFIFYLL 179
Cdd:TIGR00881 162 IVSLICFLL 170
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
12-304 |
6.74e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.47 E-value: 6.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 12 LISSFFMSFGYFAVYAFLAIyLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGI 91
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSL-RLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 92 CSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDsiYAFFLTGSLML 170
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALaTNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG--ALPFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 171 LFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQLtvaLPLHMKNISNSNQLATLVITINAIT 250
Cdd:cd17477 159 LLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSL---LPLYGLRLGLSVAQAALLLAAFVLG 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1266290634 251 GVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFIcVILFTIG 304
Cdd:cd17477 236 GLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL-VLLFLWG 288
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-180 |
8.92e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.10 E-value: 8.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 10 FMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIAL 89
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 90 GICS-DFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIY--AFFLT 165
Cdd:COG2223 289 ALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYtaAFLVF 368
|
170
....*....|....*
gi 1266290634 166 GSLMLLFAFIFYLLK 180
Cdd:COG2223 369 AVLALVALVLTLLLY 383
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
4-168 |
1.46e-04 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 43.97 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 4 FSIPI-RFMLISSFFMSFGYFaVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLR 82
Cdd:pfam05977 7 LRQGVfRVIWIASLASNLGTL-MQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 83 GIGFIALGICSDFYTISISSALI-----GFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLL-- 154
Cdd:pfam05977 86 ALVSTLLTLLAGLGLLSPWLLLGltflgGIGTALMDPAWQASVPELvPRRDLPAAVALNSVGYNIARSVGPALGGVLLaa 165
|
170 180
....*....|....*....|.
gi 1266290634 155 -------LLDSIYAFFLTGSL 168
Cdd:pfam05977 166 fgpaftfALNALSYFAVIAAL 186
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
11-179 |
2.73e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 42.61 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 11 MLISSFFMSFGYFAV---YAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFI 87
Cdd:cd17345 4 VFLGIFIGYAGYYLVrnnFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 88 ALG-ICSDFYTISISSALIGFGTAF----YEPAARAIFGSQPAHMRKNLFTYLNLSFNCG-AIIGPIAG---GFLLLLDS 158
Cdd:cd17345 84 LIGfVPSATSSVGLMFILLFLNGWFqgmgWPPSGRTMVHWFSKKERGTWTSIWNISHNVGgGLVGPLAGlglAIFGDGWW 163
|
170 180
....*....|....*....|.
gi 1266290634 159 IYAFFLTGSLMLLFAFIFYLL 179
Cdd:cd17345 164 RGAFIFPAIIAIIVAVIVLFL 184
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
37-375 |
2.94e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.64 E-value: 2.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 37 LHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTA--FYEP 114
Cdd:cd17355 33 FGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAgtLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 115 AARAIFGSQPAHMRKNLFTYLNLSFNCGAIIG-PIAGGFLLLLDSIYAFFLTGSLMLLFAFIFYLL--------KNHFQV 185
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFlPLGAALIEAFGWRTALLVLALLALLVLVPVLLLlrrrpadlALRAYD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 186 TTENTSITLGIQAILQNKPFLL--FSFIMIFFYIMFtqLTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFH 263
Cdd:cd17355 193 DASPASPGSTLKEALRSASFWLlaLAFFLCGFAVVG--LIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 264 KYNTLSIIKYGILLMGISFLLIPLFQHPY---WLFICVILFTIGETlVLPNADIAIANYSNESYtATYFGFYQLSLAFGF 340
Cdd:cd17355 271 RYSPRRLLAASYALRALGLALLLLLPFPPlalLLFAALFGLGWGAT-VPLTAALAARYFGARSY-GTLFGLVFAPHQLGS 348
|
330 340 350
....*....|....*....|....*....|....*
gi 1266290634 341 IIGNYTGTSFTSNLNGMYTPWLIFSGIGLIGFISL 375
Cdd:cd17355 349 ALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
59-210 |
4.49e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.22 E-value: 4.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 59 PLFSGLiADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAARAIFG-SQPAHMRKNLFTYLNL 137
Cdd:cd17328 52 PIFGYL-GDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIAdLFPKEKRTRALGVFYF 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 138 SFNCGAIIGPIAGGFL--LLLDSIYAFFLTGSLMLLFAFIFYLL---------KNHFQVTTENTSITLGIQAILQNKPFL 206
Cdd:cd17328 131 AIPLGSGLGYVVGGLVaqATGGWRWAFRVTGVLGVLLAILLLLFvrepprgaaEGGVMAKSTATSFLADLKALAKNPSFI 210
|
....
gi 1266290634 207 LFSF 210
Cdd:cd17328 211 LSTL 214
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
207-375 |
5.73e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 5.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 207 LFSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIP 286
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 287 LFQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLnGMYTPWLIFSG 366
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLILAI 159
|
....*....
gi 1266290634 367 IGLIGFISL 375
Cdd:pfam07690 160 LSLLAAVLL 168
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
208-381 |
9.94e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 9.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 208 FSFIMIFFYIMFTQLTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPL 287
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 288 FQHPYWLFICVILFTIGETLVLPNADIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYTPWLIFSGI 367
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170
....*....|....
gi 1266290634 368 GLIGFISLHILNIK 381
Cdd:cd06174 161 LALLAAILLLLVVP 174
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
222-373 |
1.14e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 222 LTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILF 301
Cdd:cd17477 15 LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVM 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1266290634 302 TIGETLVLPNADIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNlngMYTPWLIFSGIGLIGFI 373
Cdd:cd17477 95 GIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA---GALPFLIAAVLLLLALV 163
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-179 |
1.19e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 9 RFMLISSFF--MSFGYFAVYAFLAIYLLTfLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYI-IMMIAGLFLRGIG 85
Cdd:COG2807 216 LAWLLTLFFglQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrPLLLLLGLLGLAG 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 86 FIALGICSDFYTIsISSALIGFGTAFYEPAARAIFG--SQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLL-LLDSIYAF 162
Cdd:COG2807 295 LLGLLLAPGSLPW-LWAVLLGLGQGGLFPLALTLIGlrARTPAEAAALSGMAQSVGYLLAALGPLLVGALHdATGSWTAA 373
|
170
....*....|....*..
gi 1266290634 163 FLTGSLMLLFAFIFYLL 179
Cdd:COG2807 374 LLLLAALAVLMLVAGLL 390
|
|
| MFS_SLC15A1_2_like |
cd17347 |
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ... |
8-221 |
1.85e-03 |
|
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340905 [Multi-domain] Cd Length: 427 Bit Score: 40.29 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 8 IRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADK-IGYIIMMIAGLFLRGIGF 86
Cdd:cd17347 4 VPFIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSyLGKYRTILYLSLVYCLGH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 87 IALGICS-------DFYTISISSALIGFGTAFYEPAARAI----FGSQPAHMRKNLFTYLNLSFNCGA----IIGPIA-G 150
Cdd:cd17347 84 IVLAVTAipplgppHVWGLLIGLLLIAIGTGGIKPCVSAFggdqFGADQQHLLARFFSWFYFAINAGSllstFLTPILrA 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1266290634 151 GFLLLLDSIY--AFFLTGSLMLLFAFIFYLLKNHFQvttentsitlGIQAILqnKPFLLFSFImIFFYIMFTQ 221
Cdd:cd17347 164 DVQFGGHDCYplAFGVPGVLMAVATLVFWLGRKHYK----------DVKALL--RVLVLFIPL-PVFWALFDQ 223
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
60-318 |
2.55e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.55 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 60 LFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAARAIFG-SQPAHMRKNL-FTYLNL 137
Cdd:cd17476 51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGrTYPPGPRKNIvFSLFGA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 138 SFNCGAIIGPIAGGFLLLLDSIYAFFLTGSLMLLFAFIFYLLknhfqVTTENTSITLGIQailqnkpFLLFSFIMIF-FY 216
Cdd:cd17476 131 TAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIF-----WTSPSFIAVLLAV-------FLGWASFGIWvFY 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 217 IMFTQLTVALplhmknisNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLF--QHPYWL 294
Cdd:cd17476 199 ATQYFQNVRG--------YSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVAFLVGPILFATMpvHQTYWA 270
|
250 260
....*....|....*....|....*.
gi 1266290634 295 --FICVILFTIGETLVLPNADIAIAN 318
Cdd:cd17476 271 qaFPAMIVAPFGMDFSFPAATIIASN 296
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
7-179 |
2.64e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 7 PIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYI-IMMIAGLFLRGIG 85
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRkPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 86 FIALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFL 164
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELfPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363
|
170
....*....|....*
gi 1266290634 165 TGSLMLLFAFIFYLL 179
Cdd:cd06174 364 LVLAVLLLLAAILLL 378
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
10-373 |
2.85e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 10 FMLISSFFMSFGYFAVYAF--LAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFI 87
Cdd:cd17353 4 LVLLGAVLMHLILGYQYAWsvFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 88 ALGICSDFYTISISSALI---GFGTAFYEPAARAIfgsQPAHMRKNLFTYL-NLSFNCGAII-GPIAGGFLLLLDSIYAF 162
Cdd:cd17353 84 LSAFAISLPLLFLGYGVLggiGAGIGYITPVSTAV---KWFPDKRGLATGIvIAGFGLGSLIfSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 163 FLTGSLMLLFAFIFYLL------------KNHFQVTTENTSITLGIQAILQNKPFLLFsFIMIFFYIMFTQLTVAL--PL 228
Cdd:cd17353 161 LILGIIFLIIIVIGAFLirdppkgwvppgVDPLANNAENSPRDYTPREMLRTPTFWLL-WLMFFLNATAGLMLIGQakPI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 229 HMKNISNSNQLATLVITINAI---TGVIFMVLFRKLFHKYNTLSIIkygILLMGISFLLIPLFQHPYWLFI---CVILFT 302
Cdd:cd17353 240 GQEFAGLDAGIAALAVSILSIfngGGRPFWGWLSDKIGRKNTLSIA---FLIQGVAMFLLPFIGSVAVLFVlgvALIGFC 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1266290634 303 IGETLVLPNAdiAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYTpWLIFSGIGLIGFI 373
Cdd:cd17353 317 YGGGFALFPA--LTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAA-FIIAAALSLVALA 384
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
9-111 |
3.26e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.48 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 9 RFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIG--- 85
Cdd:cd17503 181 TLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGtll 260
|
90 100
....*....|....*....|....*.
gi 1266290634 86 FIALGICSDFYTISISSALIGFGTAF 111
Cdd:cd17503 261 LAFLTPDTSLWLIILPLFIRGLGMGL 286
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
222-363 |
3.34e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 3.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 222 LTVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPLFQHPYWLFICVILF 301
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1266290634 302 TIGETLVLPNAdIAIANYSNESYTATYFGFYQLSLAFGFIIGNYTGTSFTSNLNGMYTPWLI 363
Cdd:cd17478 95 GIGSAAFHPEG-ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL 155
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
4-176 |
3.49e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.14 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 4 FSIPIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGY--------IIMM 75
Cdd:cd17475 196 RNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrpvlvITAA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 76 IAGLFLRGIGFIALGicSDFYTISISSALIG-FGTAFYEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLL 154
Cdd:cd17475 276 IAAAALLVLSLLSPG--TPLWLLVLLLILLGlFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLV 353
|
170 180
....*....|....*....|....
gi 1266290634 155 LLDSIY--AFFLTGSLMLLFAFIF 176
Cdd:cd17475 354 DATHSYapAWLALALLLVLAALLL 377
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
143-310 |
4.59e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.13 E-value: 4.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 143 AIIGPIAGGFLLLLDSIYAFFLTGSLMLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKPFLLFSFIMIFFYIMFTQL 222
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 223 TVALPLHMKNISNSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGILLMGISFLLIPL--FQHPYWLFICVIL 300
Cdd:cd17332 241 NTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlpPGNLVLILVLAVL 320
|
170
....*....|
gi 1266290634 301 FTIGETLVLP 310
Cdd:cd17332 321 AGIGYGGANL 330
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
19-153 |
5.78e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 38.64 E-value: 5.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 19 SFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYI-IMMIAGLFLRGIGFIALGIC----- 92
Cdd:cd17337 221 TLSQFGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRrTVRWFGGVGCAISTLLFYYVpqlfg 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1266290634 93 SDFYTISISSALIGFGTAFYEPAArAIFGSQPAHMRKNLFTYLNLSFNCGAIIGP-IAGGFL 153
Cdd:cd17337 301 HNYWAALIAAILFGIGLAGFVPLS-ALMPSLAPEHKGAAMSILNLGAGLSNFVGPaIVTLFL 361
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
11-178 |
6.00e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 6.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 11 MLISSFFMSFGYFAVYAFLAIYLL----TFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGF 86
Cdd:cd17504 182 ANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGL 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 87 IALGIC-SDFYTISISSALIGFGTAF-YEPAARAIFGSQPAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFL 164
Cdd:cd17504 262 LLLALLhSSLWALVVALLLIGIGLGLaFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSG 341
|
170
....*....|....
gi 1266290634 165 TGSLMLLFAFIFYL 178
Cdd:cd17504 342 GVPTEGAYVLAFLI 355
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-178 |
8.73e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.01 E-value: 8.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 11 MLISSFFMSFGYFAVYAFLAIYLLTFLHFS---AVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFI 87
Cdd:cd17391 206 LFVTTFIIQLANQSIEPILTLYIRQLMGDAsnlAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYI 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 88 ALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQ-PAHMRKNLFTYLNLSFNCGAIIGPIAGGFLLLLDSIYAFFLTG 166
Cdd:cd17391 286 PQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKItPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVT 365
|
170
....*....|..
gi 1266290634 167 SLMLLFAFIFYL 178
Cdd:cd17391 366 ALLVLLNAIWSF 377
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
5-179 |
9.40e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 37.95 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 5 SIPIRFMLISSFFMSFGYFAVYAFLAIYlLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGI 84
Cdd:cd17335 197 NPRVLAFLLVAFLMGFGHGLIYSFLFWH-LQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVV 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266290634 85 GFIALGICSDFYTISISSALIGFGTAFYEPAA-RAIFGSQPAHMRKNLFTYLN-LSFNCGAIIGPIAGGFLL-LLDSIYA 161
Cdd:cd17335 276 RWLLYSFLENPWLVLPIELLHGLTFALVWAAAvSYASAAAPPGLRATAQGLLQgLYFGLGGGLGSLIGGYLYeAFGARTT 355
|
170
....*....|....*...
gi 1266290634 162 FFLTGSLMLLFAFIFYLL 179
Cdd:cd17335 356 FRFFAIAALAGLLAFFLI 373
|
|
| |
