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Conserved domains on  [gi|1266660872|gb|PHF39867|]
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glycosyl transferase [Bacillus toyonensis]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 277-458 2.98e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 92.07  E-value: 2.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKI--EPFEIIVVVNGSSDKTATIAKEKGA-----TTIIYKEALGNDVGRSLGTYFAKG 349
Cdd:COG0463     4 VSVVIPTYNEEEYLEEALESLLAQtyPDFEIIVVDDGSTDGTAEILRELAAkdpriRVIRLERNRGKGAARNAGLAAARG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 350 EIVLFIDGDFVIPASELYPFAKAIADGQ-DVALNDLNHYLDLRVPLHLVTAFKYALNLACDRKDLGVGsliavPNAFSKT 428
Cdd:COG0463    84 DYIAFLDADDQLDPEKLEELVAALEEGPaDLVYGSRLIREGESDLRRLGSRLFNLVRLLTNLPDSTSG-----FRLFRRE 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 1266660872 429 CLKAIGYRSLLSPCVAQVKAVLSGFEIACV 458
Cdd:COG0463   159 VLEELGFDEGFLEDTELLRALRHGFRIAEV 188
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 9-188 2.39e-20

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 89.38  E-value: 2.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVDTISDVIKSVK--PFNPVEIIVVANGCNDGTEGVAESLG-----CRVIQNKESLGNDVGRAVGAKHAIG 81
Cdd:COG0463     4 VSVVIPTYNEEEYLEEALESLLaqTYPDFEIIVVDDGSTDGTAEILRELAakdprIRVIRLERNRGKGAARNAGLAAARG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  82 DVLLFIDGDFAIQTSKLQLFLNPILHDQADIVLNNldalflkKQKPHSVTVWRQILNAM--LEREELKIDSLLSVPHALT 159
Cdd:COG0463    84 DYIAFLDADDQLDPEKLEELVAALEEGPADLVYGS-------RLIREGESDLRRLGSRLfnLVRLLTNLPDSTSGFRLFR 156

                         170       180
                  ....*....|....*....|....*....
gi 1266660872 160 KEVVQSIGYECFVNPIVAHLRLAQSKWKI 188
Cdd:COG0463   157 REVLEELGFDEGFLEDTELLRALRHGFRI 185
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 277-458 2.98e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 92.07  E-value: 2.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKI--EPFEIIVVVNGSSDKTATIAKEKGA-----TTIIYKEALGNDVGRSLGTYFAKG 349
Cdd:COG0463     4 VSVVIPTYNEEEYLEEALESLLAQtyPDFEIIVVDDGSTDGTAEILRELAAkdpriRVIRLERNRGKGAARNAGLAAARG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 350 EIVLFIDGDFVIPASELYPFAKAIADGQ-DVALNDLNHYLDLRVPLHLVTAFKYALNLACDRKDLGVGsliavPNAFSKT 428
Cdd:COG0463    84 DYIAFLDADDQLDPEKLEELVAALEEGPaDLVYGSRLIREGESDLRRLGSRLFNLVRLLTNLPDSTSG-----FRLFRRE 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 1266660872 429 CLKAIGYRSLLSPCVAQVKAVLSGFEIACV 458
Cdd:COG0463   159 VLEELGFDEGFLEDTELLRALRHGFRIAEV 188
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 9-188 2.39e-20

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 89.38  E-value: 2.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVDTISDVIKSVK--PFNPVEIIVVANGCNDGTEGVAESLG-----CRVIQNKESLGNDVGRAVGAKHAIG 81
Cdd:COG0463     4 VSVVIPTYNEEEYLEEALESLLaqTYPDFEIIVVDDGSTDGTAEILRELAakdprIRVIRLERNRGKGAARNAGLAAARG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  82 DVLLFIDGDFAIQTSKLQLFLNPILHDQADIVLNNldalflkKQKPHSVTVWRQILNAM--LEREELKIDSLLSVPHALT 159
Cdd:COG0463    84 DYIAFLDADDQLDPEKLEELVAALEEGPADLVYGS-------RLIREGESDLRRLGSRLfnLVRLLTNLPDSTSGFRLFR 156

                         170       180
                  ....*....|....*....|....*....
gi 1266660872 160 KEVVQSIGYECFVNPIVAHLRLAQSKWKI 188
Cdd:COG0463   157 REVLEELGFDEGFLEDTELLRALRHGFRI 185
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 9-90 2.57e-17

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 81.02  E-value: 2.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVDTISDVIKSVKPF-NPVEIIVVANGCNDGTEGVAESLGCRVIQNKeslgndVGRAV----GAKHAIGDV 83
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALrGDAEVIVVDGGSTDGTVEIARSLGAKVIHSP------KGRARqmnaGAALAKGDI 74


                  ....*..
gi 1266660872  84 LLFIDGD 90
Cdd:TIGR04283  75 LLFLHAD 81
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 11-114 8.85e-17

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 78.38  E-value: 8.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  11 VIIPVCNEVDTISDVIKSVKPF----NPVEIIVVANGCNDGTEGVAESLGC-----RVIQNKESLGndVGRAV--GAKHA 79
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAVleegYDYEIIVVDDGSTDGTAEIARELAArvprvRVIRLSRNFG--KGAAVraGFKAA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1266660872  80 IGDVLLFIDGDFAIQTSKLQLFLNPILHDQADIVL 114
Cdd:cd04179    79 RGDIVVTMDADLQHPPEDIPKLLEKLLEGGADVVI 113
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 10-114 1.32e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 77.44  E-value: 1.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  10 SVIIPVCNEVDTISDVIKSVK--PFNPVEIIVVANGCNDGTEGVAESL-----GCRVIQNKESLGNDVGRAVGAKHAIGD 82
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLnqTYPNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1266660872  83 VLLFIDGDFAIQTSKLQLFLNPILHDQADIVL 114
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVV 112
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 279-381 3.67e-16

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 76.46  E-value: 3.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRKI----EPFEIIVVVNGSSDKTATIAKEKGAT-----TIIYKEALGndVGRSL--GTYFA 347
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAVleegYDYEIIVVDDGSTDGTAEIARELAARvprvrVIRLSRNFG--KGAAVraGFKAA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1266660872 348 KGEIVLFIDGDFVIPASELYPF-AKAIADGQDVAL 381
Cdd:cd04179    79 RGDIVVTMDADLQHPPEDIPKLlEKLLEGGADVVI 113
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 277-380 6.03e-15

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 74.09  E-value: 6.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKI-EPFEIIVVVNGSSDKTATIAKEKGATTIIykealgNDVGRS----LGTYFAKGEI 351
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALrGDAEVIVVDGGSTDGTVEIARSLGAKVIH------SPKGRArqmnAGAALAKGDI 74

                          90       100
                  ....*....|....*....|....*....
gi 1266660872 352 VLFIDGDFVIPASELYPFAKAIADGQDVA 380
Cdd:TIGR04283  75 LLFLHADTRLPKDFLEAIRRALAKPGYVA 103
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 273-358 2.76e-13

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 70.72  E-value: 2.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 273 KGKQLSVIIPVQDEEKTIGNVIEELRK--IEPF--EIIVVVNGSSDKTATIAKEKGATTIIYKEAL---------GNDVG 339
Cdd:PRK13915   29 AGRTVSVVLPALNEEETVGKVVDSIRPllMEPLvdELIVIDSGSTDATAERAAAAGARVVSREEILpelpprpgkGEALW 108

                          90
                  ....*....|....*....
gi 1266660872 340 RSLgtYFAKGEIVLFIDGD 358
Cdd:PRK13915  109 RSL--AATTGDIVVFVDAD 125
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 278-376 9.24e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 66.26  E-value: 9.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 278 SVIIPVQDEEKTIGNVIEELRKI--EPFEIIVVVNGSSDKTATIAKE-----KGATTIIYKEALGNDVGRSLGTYFAKGE 350
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQtyPNFEIIVVDDGSTDGTVEIAEEyakkdPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100
                  ....*....|....*....|....*.
gi 1266660872 351 IVLFIDGDFVIPASELYPFAKAIADG 376
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEED 106
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 8-90 3.36e-09

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 58.01  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   8 SLSVIIPVCNEVDTISDVIKSVKPF----NPVEIIVVANGCNDGTEGVAESLGCRVIQNKESLgNDVGRAVGAKHAI--- 80
Cdd:PRK13915   32 TVSVVLPALNEEETVGKVVDSIRPLlmepLVDELIVIDSGSTDATAERAAAAGARVVSREEIL-PELPPRPGKGEALwrs 110

                          90
                  ....*....|....*
gi 1266660872  81 -----GDVLLFIDGD 90
Cdd:PRK13915  111 laattGDIVVFVDAD 125
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 277-458 2.98e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 92.07  E-value: 2.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKI--EPFEIIVVVNGSSDKTATIAKEKGA-----TTIIYKEALGNDVGRSLGTYFAKG 349
Cdd:COG0463     4 VSVVIPTYNEEEYLEEALESLLAQtyPDFEIIVVDDGSTDGTAEILRELAAkdpriRVIRLERNRGKGAARNAGLAAARG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 350 EIVLFIDGDFVIPASELYPFAKAIADGQ-DVALNDLNHYLDLRVPLHLVTAFKYALNLACDRKDLGVGsliavPNAFSKT 428
Cdd:COG0463    84 DYIAFLDADDQLDPEKLEELVAALEEGPaDLVYGSRLIREGESDLRRLGSRLFNLVRLLTNLPDSTSG-----FRLFRRE 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 1266660872 429 CLKAIGYRSLLSPCVAQVKAVLSGFEIACV 458
Cdd:COG0463   159 VLEELGFDEGFLEDTELLRALRHGFRIAEV 188
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 9-188 2.39e-20

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 89.38  E-value: 2.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVDTISDVIKSVK--PFNPVEIIVVANGCNDGTEGVAESLG-----CRVIQNKESLGNDVGRAVGAKHAIG 81
Cdd:COG0463     4 VSVVIPTYNEEEYLEEALESLLaqTYPDFEIIVVDDGSTDGTAEILRELAakdprIRVIRLERNRGKGAARNAGLAAARG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  82 DVLLFIDGDFAIQTSKLQLFLNPILHDQADIVLNNldalflkKQKPHSVTVWRQILNAM--LEREELKIDSLLSVPHALT 159
Cdd:COG0463    84 DYIAFLDADDQLDPEKLEELVAALEEGPADLVYGS-------RLIREGESDLRRLGSRLfnLVRLLTNLPDSTSGFRLFR 156

                         170       180
                  ....*....|....*....|....*....
gi 1266660872 160 KEVVQSIGYECFVNPIVAHLRLAQSKWKI 188
Cdd:COG0463   157 REVLEELGFDEGFLEDTELLRALRHGFRI 185
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 9-90 2.57e-17

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 81.02  E-value: 2.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVDTISDVIKSVKPF-NPVEIIVVANGCNDGTEGVAESLGCRVIQNKeslgndVGRAV----GAKHAIGDV 83
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALrGDAEVIVVDGGSTDGTVEIARSLGAKVIHSP------KGRARqmnaGAALAKGDI 74


                  ....*..
gi 1266660872  84 LLFIDGD 90
Cdd:TIGR04283  75 LLFLHAD 81
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 11-114 8.85e-17

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 78.38  E-value: 8.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  11 VIIPVCNEVDTISDVIKSVKPF----NPVEIIVVANGCNDGTEGVAESLGC-----RVIQNKESLGndVGRAV--GAKHA 79
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAVleegYDYEIIVVDDGSTDGTAEIARELAArvprvRVIRLSRNFG--KGAAVraGFKAA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1266660872  80 IGDVLLFIDGDFAIQTSKLQLFLNPILHDQADIVL 114
Cdd:cd04179    79 RGDIVVTMDADLQHPPEDIPKLLEKLLEGGADVVI 113
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 10-114 1.32e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 77.44  E-value: 1.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  10 SVIIPVCNEVDTISDVIKSVK--PFNPVEIIVVANGCNDGTEGVAESL-----GCRVIQNKESLGNDVGRAVGAKHAIGD 82
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLnqTYPNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1266660872  83 VLLFIDGDFAIQTSKLQLFLNPILHDQADIVL 114
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVV 112
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 279-381 3.67e-16

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 76.46  E-value: 3.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRKI----EPFEIIVVVNGSSDKTATIAKEKGAT-----TIIYKEALGndVGRSL--GTYFA 347
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAVleegYDYEIIVVDDGSTDGTAEIARELAARvprvrVIRLSRNFG--KGAAVraGFKAA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1266660872 348 KGEIVLFIDGDFVIPASELYPF-AKAIADGQDVAL 381
Cdd:cd04179    79 RGDIVVTMDADLQHPPEDIPKLlEKLLEGGADVVI 113
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 277-380 6.03e-15

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 74.09  E-value: 6.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKI-EPFEIIVVVNGSSDKTATIAKEKGATTIIykealgNDVGRS----LGTYFAKGEI 351
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALrGDAEVIVVDGGSTDGTVEIARSLGAKVIH------SPKGRArqmnAGAALAKGDI 74

                          90       100
                  ....*....|....*....|....*....
gi 1266660872 352 VLFIDGDFVIPASELYPFAKAIADGQDVA 380
Cdd:TIGR04283  75 LLFLHADTRLPKDFLEAIRRALAKPGYVA 103
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 8-117 7.65e-15

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 75.16  E-value: 7.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   8 SLSVIIPVCNEVDTISDVIKSVK----PFNPVEIIVVANGCNDGTEGVAESLG-----CRVIQNKESLGNDVGRAVGAKH 78
Cdd:COG1215    30 RVSVIIPAYNEEAVIEETLRSLLaqdyPKEKLEVIVVDDGSTDETAEIARELAaeyprVRVIERPENGGKAAALNAGLKA 109

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1266660872  79 AIGDVLLFIDGDFAIQTSKLQLFLNPILHDQADIVLNNL 117
Cdd:COG1215   110 ARGDIVVFLDADTVLDPDWLRRLVAAFADPGVGASGANL 148
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 9-90 1.63e-14

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 72.60  E-value: 1.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVDTISDVIKSVKPFN--PVEIIVVANGCNDGTEGVAESLGCRVIQNKEslgndvGRAV----GAKHAIGD 82
Cdd:cd02522     1 LSIIIPTLNEAENLPRLLASLRRLNplPLEIIVVDGGSTDGTVAIARSAGVVVISSPK------GRARqmnaGAAAARGD 74


                  ....*...
gi 1266660872  83 VLLFIDGD 90
Cdd:cd02522    75 WLLFLHAD 82
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 279-381 2.33e-14

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 70.61  E-value: 2.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRK--IEPFEIIVVVNGSSDKTATIAKEKGA-----TTIIYKEALGNDVGRSLGTYFAKGEI 351
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAqtYPNFEVIVVDDGSTDGTLEILEEYAKkdprvIRVINEENQGLAAARNAGLKAARGEY 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1266660872 352 VLFIDGDFVIPASELYPFAKAIADGQDVAL 381
Cdd:cd00761    81 ILFLDADDLLLPDWLERLVAELLADPEADA 110
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 11-113 6.74e-14

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 69.46  E-value: 6.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  11 VIIPVCNEVDTISDVIKSVKP--FNPVEIIVVANGCNDGTEGVAESLGC-----RVIQNKESLGNDVGRAVGAKHAIGDV 83
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAqtYPNFEVIVVDDGSTDGTLEILEEYAKkdprvIRVINEENQGLAAARNAGLKAARGEY 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1266660872  84 LLFIDGDFAIQTSKLQ-LFLNPILHDQADIV 113
Cdd:cd00761    81 ILFLDADDLLLPDWLErLVAELLADPEADAV 111
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
5-90 9.09e-14

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 70.02  E-value: 9.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   5 MAKSLSVIIPVCNEVDTISDVIKSVK--PFNPVEIIVVANGCNDGTEGVAESL---GCRVIQNKESLGNDVGRAVGAKHA 79
Cdd:COG1216     1 MRPKVSVVIPTYNRPELLRRCLESLLaqTYPPFEVIVVDNGSTDGTAELLAALafpRVRVIRNPENLGFAAARNLGLRAA 80

                          90
                  ....*....|.
gi 1266660872  80 IGDVLLFIDGD 90
Cdd:COG1216    81 GGDYLLFLDDD 91
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 273-358 2.76e-13

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 70.72  E-value: 2.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 273 KGKQLSVIIPVQDEEKTIGNVIEELRK--IEPF--EIIVVVNGSSDKTATIAKEKGATTIIYKEAL---------GNDVG 339
Cdd:PRK13915   29 AGRTVSVVLPALNEEETVGKVVDSIRPllMEPLvdELIVIDSGSTDATAERAAAAGARVVSREEILpelpprpgkGEALW 108

                          90
                  ....*....|....*....
gi 1266660872 340 RSLgtYFAKGEIVLFIDGD 358
Cdd:PRK13915  109 RSL--AATTGDIVVFVDAD 125
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 278-376 9.24e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 66.26  E-value: 9.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 278 SVIIPVQDEEKTIGNVIEELRKI--EPFEIIVVVNGSSDKTATIAKE-----KGATTIIYKEALGNDVGRSLGTYFAKGE 350
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQtyPNFEIIVVDDGSTDGTVEIAEEyakkdPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100
                  ....*....|....*....|....*.
gi 1266660872 351 IVLFIDGDFVIPASELYPFAKAIADG 376
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEED 106
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 277-382 1.28e-12

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 68.61  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKI----EPFEIIVVVNGSSDKTATIAKEKGAT----TIIYKEALGNdVGRSL--GTYF 346
Cdd:COG1215    31 VSVIIPAYNEEAVIEETLRSLLAQdypkEKLEVIVVDDGSTDETAEIARELAAEyprvRVIERPENGG-KAAALnaGLKA 109

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1266660872 347 AKGEIVLFIDGDFVIPASELYPFAKAIADgQDVALN 382
Cdd:COG1215   110 ARGDIVVFLDADTVLDPDWLRRLVAAFAD-PGVGAS 144
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 277-362 3.05e-12

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 66.05  E-value: 3.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKI--EPFEIIVVVNGSSDKTATIAKEKGAtTIIYKEAlgndvGRSL----GTYFAKGE 350
Cdd:cd02522     1 LSIIIPTLNEAENLPRLLASLRRLnpLPLEIIVVDGGSTDGTVAIARSAGV-VVISSPK-----GRARqmnaGAAAARGD 74

                          90
                  ....*....|..
gi 1266660872 351 IVLFIDGDFVIP 362
Cdd:cd02522    75 WLLFLHADTRLP 86
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 11-113 1.31e-11

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 64.13  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  11 VIIPVCNEVDTIS-------DVIKSVKPFnPVEIIVVANGCNDGTEGVAESLG------CRVIQNKESLGNdvGRAV--G 75
Cdd:cd04188     1 VVIPAYNEEKRLPptleeavEYLEERPSF-SYEIIVVDDGSKDGTAEVARKLArknpalIRVLTLPKNRGK--GGAVraG 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1266660872  76 AKHAIGDVLLFIDGDFAIQTSKLQLFLNPILHDQADIV 113
Cdd:cd04188    78 MLAARGDYILFADADLATPFEELEKLEEALKTSGYDIA 115
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 277-389 2.46e-11

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 63.46  E-value: 2.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKIEPfEIIVVVNGSSDKTATIAKEKGATtiIYKEALGNDVG-RSLGTYFAKGEIVLFI 355
Cdd:cd02511     2 LSVVIITKNEERNIERCLESVKWAVD-EIIVVDSGSTDRTVEIAKEYGAK--VYQRWWDGFGAqRNFALELATNDWVLSL 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1266660872 356 DGDFVIPAsELYP-FAKAIADGQDVA--LNDLNHYLD 389
Cdd:cd02511    79 DADERLTP-ELADeILALLATDDYDGyyVPRRNFFLG 114
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 278-362 3.12e-11

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 63.40  E-value: 3.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 278 SVIIPVQDEEKTIGNVIEELRK----IEPFEIIVVVNGSSDKTATIAKEKGAT----TIIYKEALGNDVGRSLGTYFAKG 349
Cdd:cd02525     3 SIIIPVRNEEKYIEELLESLLNqsypKDLIEIIVVDGGSTDGTREIVQEYAAKdpriRLIDNPKRIQSAGLNIGIRNSRG 82

                          90
                  ....*....|...
gi 1266660872 350 EIVLFIDGDFVIP 362
Cdd:cd02525    83 DIIIRVDAHAVYP 95
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 11-114 5.05e-11

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 62.55  E-value: 5.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  11 VIIPVCNEVDTISDVI----KSVKPFNpVEIIVVANGCNDGTEGVAESL-----GCRVIQNKESLGndVGRAV--GAKHA 79
Cdd:cd06442     1 IIIPTYNERENIPELIerldAALKGID-YEIIVVDDNSPDGTAEIVRELakeypRVRLIVRPGKRG--LGSAYieGFKAA 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1266660872  80 IGDVLLFIDGDFAIQTSKLQLFLNPILHDQADIVL 114
Cdd:cd06442    78 RGDVIVVMDADLSHPPEYIPELLEAQLEGGADLVI 112
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 279-362 8.60e-11

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 61.09  E-value: 8.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRKI--EPFEIIVVVNGSSDKTATIAKEKGATTIIYKEALGNDVGRS------LGTYFAKGE 350
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLLALdyPKLEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDKENGGkagalnAGLRHAKGD 80

                          90
                  ....*....|..
gi 1266660872 351 IVLFIDGDFVIP 362
Cdd:cd06423    81 IVVVLDADTILE 92
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 9-90 1.21e-09

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 58.45  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVDTISDVIKSVKPFNPvEIIVVANGCNDGTEGVAESLGCRVIQNKEslgNDVGRAV--GAKHAIGDVLLF 86
Cdd:cd02511     2 LSVVIITKNEERNIERCLESVKWAVD-EIIVVDSGSTDRTVEIAKEYGAKVYQRWW---DGFGAQRnfALELATNDWVLS 77


                  ....
gi 1266660872  87 IDGD 90
Cdd:cd02511    78 LDAD 81
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 279-380 1.87e-09

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 57.58  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEEL------RKIEPFEIIVVVNGSSDKTATIAKEkgattiiYKEALGNDV-----------GRS 341
Cdd:cd04188     1 VVIPAYNEEKRLPPTLEEAveyleeRPSFSYEIIVVDDGSKDGTAEVARK-------LARKNPALIrvltlpknrgkGGA 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1266660872 342 L--GTYFAKGEIVLFIDGDFVIPASELYP-FAKAIADGQDVA 380
Cdd:cd04188    74 VraGMLAARGDYILFADADLATPFEELEKlEEALKTSGYDIA 115
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
277-362 2.28e-09

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 57.31  E-value: 2.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRK--IEPFEIIVVVNGSSDKTATIAKE---KGATTIIYKEALGNDVGRSLGTYFAKGEI 351
Cdd:COG1216     5 VSVVIPTYNRPELLRRCLESLLAqtYPPFEVIVVDNGSTDGTAELLAAlafPRVRVIRNPENLGFAAARNLGLRAAGGDY 84

                          90
                  ....*....|.
gi 1266660872 352 VLFIDGDFVIP 362
Cdd:COG1216    85 LLFLDDDTVVE 95
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 9-167 3.03e-09

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 57.38  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVDTISDVIKS--VKPFNPVEIIVVANGCNDGTEGVAESLG-------CRVIQNKESLGNDVGRA--VGAK 77
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAilAQPYPPVEVVVVVNPSDAETLDVAEEIAarfpdvrLRVIRNARLLGPTGKSRglNHGF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  78 HAI-GDVLLFIDGDFAIQTSKLQLFLNPILHDQADIV-----LNNLDALFLKKQKpHSVTVWRqiLNAMLEREELKIDSL 151
Cdd:pfam13641  84 RAVkSDLVVLHDDDSVLHPGTLKKYVQYFDSPKVGAVgtpvfSLNRSTMLSALGA-LEFALRH--LRMMSLRLALGVLPL 160

                         170
                  ....*....|....*.
gi 1266660872 152 LSVPHALTKEVVQSIG 167
Cdd:pfam13641 161 SGAGSAIRREVLKELG 176
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 8-90 3.36e-09

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 58.01  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   8 SLSVIIPVCNEVDTISDVIKSVKPF----NPVEIIVVANGCNDGTEGVAESLGCRVIQNKESLgNDVGRAVGAKHAI--- 80
Cdd:PRK13915   32 TVSVVLPALNEEETVGKVVDSIRPLlmepLVDELIVIDSGSTDATAERAAAAGARVVSREEIL-PELPPRPGKGEALwrs 110

                          90
                  ....*....|....*
gi 1266660872  81 -----GDVLLFIDGD 90
Cdd:PRK13915  111 laattGDIVVFVDAD 125
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 276-380 1.13e-08

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 56.59  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 276 QLSVIIPVQDEEKTIGNVIEEL--RKIEPFEIIVVVNGSSDKTATIAKEKGA----TTIIYKEALGNDVGRSLGTYFAKG 349
Cdd:PRK10073    7 KLSIIIPLYNAGKDFRAFMESLiaQTWTALEIIIVNDGSTDNSVEIAKHYAEnyphVRLLHQANAGVSVARNTGLAVATG 86

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1266660872 350 EIVLFIDGDFVIpASELYP--FAKAIADGQDVA 380
Cdd:PRK10073   87 KYVAFPDADDVV-YPTMYEtlMTMALEDDLDVA 118
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 277-463 3.08e-08

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 54.30  E-value: 3.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTIGNVIEELRKIE--PFEIIVVVNGSSDKTATIAKEKGA-------TTIIYKEALGNDvGRSLGTYFA 347
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAILAQPypPVEVVVVVNPSDAETLDVAEEIAArfpdvrlRVIRNARLLGPT-GKSRGLNHG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 348 ----KGEIVLFIDGDfVIPASELYPFAKAIADGQDVALNDLNHYLDLR-VPLHLVTAFKYAL-NLACDRKDLGVGSLIAV 421
Cdd:pfam13641  83 fravKSDLVVLHDDD-SVLHPGTLKKYVQYFDSPKVGAVGTPVFSLNRsTMLSALGALEFALrHLRMMSLRLALGVLPLS 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1266660872 422 PN--AFSKTCLKAIGyRSLLSPCVA-----QVKAVLSGFEIACVSRVEV 463
Cdd:pfam13641 162 GAgsAIRREVLKELG-LFDPFFLLGddkslGRRLRRHGWRVAYAPDAAV 209
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 10-168 4.04e-08

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 54.16  E-value: 4.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  10 SVIIPVCNEVDTISDVIKSVK----PFNPVEIIVVANGCNDGTEGVAESLGC-----RVIQN-KESLGndVGRAVGAKHA 79
Cdd:cd02525     3 SIIIPVRNEEKYIEELLESLLnqsyPKDLIEIIVVDGGSTDGTREIVQEYAAkdpriRLIDNpKRIQS--AGLNIGIRNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  80 IGDVLLFIDGDFAIQTSKLQLFLNPILHDQADIVLNNLDAlflkkqKPHSVTVWRQIL---------NAMLEREELKIDS 150
Cdd:cd02525    81 RGDIIIRVDAHAVYPKDYILELVEALKRTGADNVGGPMET------IGESKFQKAIAVaqssplgsgGSAYRGGAVKIGY 154

                         170
                  ....*....|....*....
gi 1266660872 151 LLSVPHAL-TKEVVQSIGY 168
Cdd:cd02525   155 VDTVHHGAyRREVFEKVGG 173
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 279-379 1.58e-07

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 51.32  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRKI-----EPFEIIVVVNGSSDKTATIAKEKGAT----TII-------YKEALgndvgrSL 342
Cdd:cd04187     1 IVVPVYNEEENLPELYERLKAVleslgYDYEIIFVDDGSTDRTLEILRELAARdprvKVIrlsrnfgQQAAL------LA 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1266660872 343 GTYFAKGEIVLFIDGDFVIPASELYPFAKAIADGQDV 379
Cdd:cd04187    75 GLDHARGDAVITMDADLQDPPELIPEMLAKWEEGYDV 111
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 11-104 3.08e-07

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 50.69  E-value: 3.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  11 VIIPVCNEVDTISDVIKSVKPFN--PVEIIVVANGCNDGTEGVAESLGCRVIQNK--ESLGNDVGRA----VGAKHAIGD 82
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLLALDypKLEVIVVDDGSTDDTLEILEELAALYIRRVlvVRDKENGGKAgalnAGLRHAKGD 80

                          90       100
                  ....*....|....*....|....*..
gi 1266660872  83 VLLFIDGDF-----AIQTSKLQLFLNP 104
Cdd:cd06423    81 IVVVLDADTilepdALKRLVVPFFADP 107
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 278-358 2.06e-06

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 49.12  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 278 SVIIPVQDEEKTIGNVIEELRKI----EPFEIIVVVNGSSDKTATIAKE---KGATTIIYKEALGNDVGRSLGTYFAKGE 350
Cdd:cd06439    32 TIIIPAYNEEAVIEAKLENLLALdyprDRLEIIVVSDGSTDGTAEIAREyadKGVKLLRFPERRGKAAALNRALALATGE 111


                  ....*...
gi 1266660872 351 IVLFIDGD 358
Cdd:cd06439   112 IVVFTDAN 119
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 11-90 5.59e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 46.40  E-value: 5.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  11 VIIPVCNEVDTISDVIKSV--KPFNPVEIIVVANGCNDGTEGVAESLG--CRVIQNKESLGndVGRA--VGAKHAIGDVL 84
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLlaQTYPDFEVIVVDNASTDGSVELLRELFpeVRLIRNGENLG--FGAGnnQGIREAKGDYV 78


                  ....*.
gi 1266660872  85 LFIDGD 90
Cdd:cd04186    79 LLLNPD 84
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 8-90 6.62e-06

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 47.58  E-value: 6.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   8 SLSVIIPVCNEVDTISDVIKSVK----PFNPVEIIVVANGCNDGTEGVAESL---GCRVIQNKESLG-----NDvgravG 75
Cdd:cd06439    30 TVTIIIPAYNEEAVIEAKLENLLaldyPRDRLEIIVVSDGSTDGTAEIAREYadkGVKLLRFPERRGkaaalNR-----A 104

                          90
                  ....*....|....*
gi 1266660872  76 AKHAIGDVLLFIDGD 90
Cdd:cd06439   105 LALATGEIVVFTDAN 119
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 279-381 1.15e-05

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 46.76  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRKI---EPFEIIVVVNGSSDKTATIAKEkgattiiYKEALGNDV------GRSLGT----- 344
Cdd:cd06442     1 IIIPTYNERENIPELIERLDAAlkgIDYEIIVVDDNSPDGTAEIVRE-------LAKEYPRVRlivrpgKRGLGSayieg 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1266660872 345 -YFAKGEIVLFIDGDFVIPASELYPFAKAIADGQ-DVAL 381
Cdd:cd06442    74 fKAARGDVIVVMDADLSHPPEYIPELLEAQLEGGaDLVI 112
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 8-90 2.13e-05

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 46.09  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   8 SLSVIIPVCNE-VDTISDVIKSVKPFNPVEIIVVANGCNDGTE---GVAESLGCRVIQNKESLGNDVGRAVGAKHAIGDV 83
Cdd:cd06434     1 DVTVIIPVYDEdPDVFRECLRSILRQKPLEIIVVTDGDDEPYLsilSQTVKYGGIFVITVPHPGKRRALAEGIRHVTTDI 80


                  ....*..
gi 1266660872  84 LLFIDGD 90
Cdd:cd06434    81 VVLLDSD 87
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 11-60 3.35e-05

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 44.51  E-value: 3.35e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1266660872  11 VIIPVCNEVDTISDVIKSVK----PFNPVEIIVVANGCNDGTEGVAESLGCRVI 60
Cdd:cd06438     1 ILIPAHNEEAVIGNTVRSLKaqdyPRELYRIFVVADNCTDDTAQVARAAGATVL 54
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 278-373 3.68e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 45.73  E-value: 3.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 278 SVIIPVQDEEKTiGNVIEELRKI-----EPFEIIVVVNGSSDKTATIAKE-KGATTIIY-----KEALGNDVGRSLGTYF 346
Cdd:pfam10111   1 SVVIPVYNGEKT-HWIQERILNQtfqydPEFELIIINDGSTDKTLEEVSSiKDHNLQVYypnapDTTYSLAASRNRGTSH 79

                          90       100
                  ....*....|....*....|....*..
gi 1266660872 347 AKGEIVLFIDGDFVIPASELYPFAKAI 373
Cdd:pfam10111  80 AIGEYISFIDGDCLWSPDKFEKQLKIA 106
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 250-358 4.77e-05

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 45.53  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 250 ESVYHTLNFEDFYQGWGVTSNLYKGKQLSVIIPVQDEEKTIGNVIEEL-----RKIEP-----FEIIVVVNGSSDKTATI 319
Cdd:PTZ00260   45 SSVIHEKSKEVDKENYINNILKDSDVDLSIVIPAYNEEDRLPKMLKETikyleSRSRKdpkfkYEIIIVNDGSKDKTLKV 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1266660872 320 AK---EKGATTII------YKEALGNDVGRSLGTYFAKGEIVLFIDGD 358
Cdd:PTZ00260  125 AKdfwRQNINPNIdirllsLLRNKGKGGAVRIGMLASRGKYILMVDAD 172
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 279-378 5.22e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 44.59  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRKI----EPFEIIVVVNGSSDKTATI---AKEKG-----ATTIIYKEALGNDVGRSLGTYF 346
Cdd:cd04192     1 VVIAARNEAENLPRLLQSLSALdypkEKFEVILVDDHSTDGTVQIlefAAAKPnfqlkILNNSRVSISGKKNALTTAIKA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1266660872 347 AKGEIVLFIDGDFVIPASELYPFAKAIADGQD 378
Cdd:cd04192    81 AKGDWIVTTDADCVVPSNWLLTFVAFIQKEQI 112
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 10-89 5.38e-05

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 45.27  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  10 SVIIPVCNEV-DTISDVIKSVKPFNPV----EIIVVANGCNDGTEGVAESL-------GCRVIQNKESLGNDVGRAVGAK 77
Cdd:cd02510     1 SVIIIFHNEAlSTLLRTVHSVINRTPPellkEIILVDDFSDKPELKLLLEEyykkylpKVKVLRLKKREGLIRARIAGAR 80

                          90
                  ....*....|..
gi 1266660872  78 HAIGDVLLFIDG 89
Cdd:cd02510    81 AATGDVLVFLDS 92
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 279-328 7.15e-05

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 43.74  E-value: 7.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRKI----EPFEIIVVVNGSSDKTATIAKEKGATTI 328
Cdd:cd06438     1 ILIPAHNEEAVIGNTVRSLKAQdyprELYRIFVVADNCTDDTAQVARAAGATVL 54
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 277-370 3.17e-04

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 42.24  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 277 LSVIIPVQDEEKTI-GNVIEELRKIEPFEIIVVVNGSSDKTATIAKEK---GATTIIYKEALGNDVGRSLGTYFAKGEIV 352
Cdd:cd06434     2 VTVIIPVYDEDPDVfRECLRSILRQKPLEIIVVTDGDDEPYLSILSQTvkyGGIFVITVPHPGKRRALAEGIRHVTTDIV 81

                          90       100
                  ....*....|....*....|..
gi 1266660872 353 LFIDGDFVIP----ASELYPFA 370
Cdd:cd06434    82 VLLDSDTVWPpnalPEMLKPFE 103
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 10-113 4.74e-04

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 41.99  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  10 SVIIPVCNE-------VDTISDVIKSVKPFnpvEIIVVANGCNDGTEGVAESLG-------CRVIQNKESLGNDVGRAVG 75
Cdd:PLN02726   12 SIIVPTYNErlnialiVYLIFKALQDVKDF---EIIVVDDGSPDGTQDVVKQLQkvygedrILLRPRPGKLGLGTAYIHG 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1266660872  76 AKHAIGDVLLFIDGDFAIQTSKLQLFLNPILHDQADIV 113
Cdd:PLN02726   89 LKHASGDFVVIMDADLSHHPKYLPSFIKKQRETGADIV 126
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 10-90 5.15e-04

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 41.38  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  10 SVIIPVCNEVDTISDVIKSVKP--FNPVEIIVVANGCNDGTEGVAESLGCRVI-------------QNKeslgndvgrav 74
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVLSqtYPNIEYIVIDGGSTDGTVDIIKKYEDKITywisepdkgiydaMNK----------- 69

                          90
                  ....*....|....*.
gi 1266660872  75 GAKHAIGDVLLFIDGD 90
Cdd:cd06433    70 GIALATGDIIGFLNSD 85
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 11-91 1.32e-03

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 39.77  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872  11 VIIPVCNEVDTISDVIKSVK-----PFNPVEIIVVANGCNDGTEGVAESLGC-----RVIQNKESLGNDVGRAVGAKHAI 80
Cdd:cd04187     1 IVVPVYNEEENLPELYERLKavlesLGYDYEIIFVDDGSTDRTLEILRELAArdprvKVIRLSRNFGQQAALLAGLDHAR 80

                          90
                  ....*....|.
gi 1266660872  81 GDVLLFIDGDF 91
Cdd:cd04187    81 GDAVITMDADL 91
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 275-379 1.99e-03

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 40.49  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 275 KQLSVIIPVQDEEKTIGNVIEELRKI-----EPFEIIVVVNGSSDKTATI------AKEKGATTIIYKEALGNDVGRSLG 343
Cdd:PRK10714    6 KKVSVVIPVYNEQESLPELIRRTTAAceslgKEYEILLIDDGSSDNSAEMlveaaqAPDSHIVAILLNRNYGQHSAIMAG 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1266660872 344 TYFAKGEIVLFIDGDFVIPASELYPFAKAIADGQDV 379
Cdd:PRK10714   86 FSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDV 121
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 278-358 2.08e-03

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 40.07  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 278 SVIIPVQDEEKTIGNVIEELRKIEP----FEIIVVVNGSSDKTATIAKekgATTIIYKEALGNDVGRS----LGTYF--- 346
Cdd:PLN02726   12 SIIVPTYNERLNIALIVYLIFKALQdvkdFEIIVVDDGSPDGTQDVVK---QLQKVYGEDRILLRPRPgklgLGTAYihg 88

                          90
                  ....*....|....*
gi 1266660872 347 ---AKGEIVLFIDGD 358
Cdd:PLN02726   89 lkhASGDFVVIMDAD 103
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 9-139 2.10e-03

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 40.52  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872   9 LSVIIPVCNEVD----TISDVIK---SVKPFNP---VEIIVVANGCNDGTEGVAESL---------GCRVIQNKESLGNd 69
Cdd:PTZ00260   72 LSIVIPAYNEEDrlpkMLKETIKyleSRSRKDPkfkYEIIIVNDGSKDKTLKVAKDFwrqninpniDIRLLSLLRNKGK- 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1266660872  70 vGRAV--GAKHAIGDVLLFIDGDFAIQT---SKLQLFLNPILHDQADIVL----NNLDALFLKKQKPhsvtvWRQILNA 139
Cdd:PTZ00260  151 -GGAVriGMLASRGKYILMVDADGATDIddfDKLEDIMLKIEQNGLGIVFgsrnHLVDSDVVAKRKW-----YRNILMY 223
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 279-362 3.22e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 38.31  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266660872 279 VIIPVQDEEKTIGNVIEELRKI--EPFEIIVVVNGSSDKTATIAKE--KGATTIIYKEALGNDVGRSLGTYFAKGEIVLF 354
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLAQtyPDFEVIVVDNASTDGSVELLRElfPEVRLIRNGENLGFGAGNNQGIREAKGDYVLL 80


                  ....*....
gi 1266660872 355 IDGD-FVIP 362
Cdd:cd04186    81 LNPDtVVEP 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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