|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
1-466 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 830.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 1 MTHYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL-Q 79
Cdd:PRK09243 1 MLMYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLgI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 80 FEEEFLHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFG 159
Cdd:PRK09243 81 FDEDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 160 TRRAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAET-HKKCVFLVDTYDTLKS 238
Cdd:PRK09243 161 SRRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETyPDNTVLLVDTYDTLKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 239 GVPNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLI 318
Cdd:PRK09243 241 GVPNAIKVAKELGDGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 319 TSFEQPALGAVYKLVAIEDtDGKLNDTIKISSNPEKITTPGLKRIYRIINRvNDHAEGDYIALDSEEPgkEERLKMFHPV 398
Cdd:PRK09243 321 TGSDAPALGGVYKLVAIEG-EGGMIPKIKLSNSPEKVTTPGRKQVYRIYDK-GGKAEADVITLADEEE--EEPLKMFHPV 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1266811158 399 HTYISKFVTNFEARELHKDIFVNGERTYELPSILDIQQYSAQSLALFWEEYMRTLNPEEYPVDLSQEC 466
Cdd:PRK09243 397 HTYKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
6-472 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 666.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 6 DDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQ-FEEEF 84
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGvFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 85 LHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAH 164
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 165 EFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETH-KKCVFLVDTYDTLkSGVPNA 243
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYpDGTTLLVDTYDTL-SGVPNA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 244 IRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSFEQ 323
Cdd:COG1488 240 IELAKELLARGGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 324 PALGAVYKLVAIEDtDGKLNDTIKISSNPEKITTPGLKRIYRIINrvNDHAEGDYIALDSEEPgkeerlkmfhpvhtyis 403
Cdd:COG1488 320 PTLGFVYKLVAVEG-DGEWRPVIKLSETPGKKSKPGRKQVYRRDE--DGKATADLVALEDEPL----------------- 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1266811158 404 kfvtNFEARELHKDIFVNGERTYELPSILDIQQYSAQSLALFWEEYMRTLNPEEYPVDLSQECWDHKMN 472
Cdd:COG1488 380 ----PGEPEPLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQ 444
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
10-465 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 607.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 10 ALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL-QFEEEFLHYL 88
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLgIFDDAFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 89 QNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAHEFDA 168
Cdd:TIGR01513 81 REFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 169 ALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETH-KKCVFLVDTYDTLKSGVPNAIRVA 247
Cdd:TIGR01513 161 ALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYpKATVLLVDTYDTLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 248 KEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSFEQPALG 327
Cdd:TIGR01513 241 KELGEQGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 328 AVYKLVAIEDTdgklnDTIKISSNPEKITTPGLKRIYRIInRVNDHAEGDYIALDsEEPgkeerlkmfHPVHTYISKFVT 407
Cdd:TIGR01513 321 GVYKLVAYEGR-----PVMKLSENPEKSTLPGRKQVFRLY-DATGKFLGDELTLA-DEP---------IEDLNQEKCTPV 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1266811158 408 NFEARELHKDIFVNGERTYELPSILDIQQYSAQSLALFWEEYMRTLNPEEYPVDLSQE 465
Cdd:TIGR01513 385 FAPVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPR 442
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
10-333 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 567.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 10 ALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL-QFEEEFLHYL 88
Cdd:cd01570 1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLgIFDEEFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 89 QNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAHEFDA 168
Cdd:cd01570 81 RGFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 169 ALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKK-CVFLVDTYDTLKSGVPNAIRVA 247
Cdd:cd01570 161 ALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDnFTLLVDTYDTLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 248 KEFGD-RIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSFEQPAL 326
Cdd:cd01570 241 KELGAlGYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPAL 320
|
....*..
gi 1266811158 327 GAVYKLV 333
Cdd:cd01570 321 GGVYKLV 327
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
11-134 |
2.26e-49 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 164.99 E-value: 2.26e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 11 LHTDLYQINMAYTYWKDGIhNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL--QFEEEFLHYL 88
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSlpYFKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1266811158 89 QNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVN 134
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
1-466 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 830.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 1 MTHYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL-Q 79
Cdd:PRK09243 1 MLMYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLgI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 80 FEEEFLHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFG 159
Cdd:PRK09243 81 FDEDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 160 TRRAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAET-HKKCVFLVDTYDTLKS 238
Cdd:PRK09243 161 SRRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETyPDNTVLLVDTYDTLKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 239 GVPNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLI 318
Cdd:PRK09243 241 GVPNAIKVAKELGDGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 319 TSFEQPALGAVYKLVAIEDtDGKLNDTIKISSNPEKITTPGLKRIYRIINRvNDHAEGDYIALDSEEPgkEERLKMFHPV 398
Cdd:PRK09243 321 TGSDAPALGGVYKLVAIEG-EGGMIPKIKLSNSPEKVTTPGRKQVYRIYDK-GGKAEADVITLADEEE--EEPLKMFHPV 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1266811158 399 HTYISKFVTNFEARELHKDIFVNGERTYELPSILDIQQYSAQSLALFWEEYMRTLNPEEYPVDLSQEC 466
Cdd:PRK09243 397 HTYKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
6-472 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 666.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 6 DDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQ-FEEEF 84
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGvFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 85 LHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAH 164
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 165 EFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETH-KKCVFLVDTYDTLkSGVPNA 243
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYpDGTTLLVDTYDTL-SGVPNA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 244 IRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSFEQ 323
Cdd:COG1488 240 IELAKELLARGGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 324 PALGAVYKLVAIEDtDGKLNDTIKISSNPEKITTPGLKRIYRIINrvNDHAEGDYIALDSEEPgkeerlkmfhpvhtyis 403
Cdd:COG1488 320 PTLGFVYKLVAVEG-DGEWRPVIKLSETPGKKSKPGRKQVYRRDE--DGKATADLVALEDEPL----------------- 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1266811158 404 kfvtNFEARELHKDIFVNGERTYELPSILDIQQYSAQSLALFWEEYMRTLNPEEYPVDLSQECWDHKMN 472
Cdd:COG1488 380 ----PGEPEPLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQ 444
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
10-465 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 607.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 10 ALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL-QFEEEFLHYL 88
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLgIFDDAFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 89 QNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAHEFDA 168
Cdd:TIGR01513 81 REFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 169 ALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETH-KKCVFLVDTYDTLKSGVPNAIRVA 247
Cdd:TIGR01513 161 ALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYpKATVLLVDTYDTLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 248 KEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSFEQPALG 327
Cdd:TIGR01513 241 KELGEQGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 328 AVYKLVAIEDTdgklnDTIKISSNPEKITTPGLKRIYRIInRVNDHAEGDYIALDsEEPgkeerlkmfHPVHTYISKFVT 407
Cdd:TIGR01513 321 GVYKLVAYEGR-----PVMKLSENPEKSTLPGRKQVFRLY-DATGKFLGDELTLA-DEP---------IEDLNQEKCTPV 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1266811158 408 NFEARELHKDIFVNGERTYELPSILDIQQYSAQSLALFWEEYMRTLNPEEYPVDLSQE 465
Cdd:TIGR01513 385 FAPVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPR 442
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
10-333 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 567.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 10 ALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL-QFEEEFLHYL 88
Cdd:cd01570 1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLgIFDEEFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 89 QNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAHEFDA 168
Cdd:cd01570 81 RGFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 169 ALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKK-CVFLVDTYDTLKSGVPNAIRVA 247
Cdd:cd01570 161 ALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDnFTLLVDTYDTLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 248 KEFGD-RIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSFEQPAL 326
Cdd:cd01570 241 KELGAlGYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPAL 320
|
....*..
gi 1266811158 327 GAVYKLV 333
Cdd:cd01570 321 GGVYKLV 327
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
6-467 |
4.15e-171 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 488.87 E-value: 4.15e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 6 DDSYALHTDLYQINMAYTYWKDGIhNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL-QFEEEF 84
Cdd:PRK12484 1 QRNLALLTDLYEVTMANAYLREGM-SAPATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLnQFSEEF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 85 LHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAH 164
Cdd:PRK12484 80 LAWLAGLRFTGDVRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVLAAAGRPVVDFGARRAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 165 EFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETH-KKCVFLVDTYDTLKsGVPNA 243
Cdd:PRK12484 160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAFPDEVAAFRAFARLYpDATTLLVDTYDTLR-GVRNA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 244 IRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSFEQ 323
Cdd:PRK12484 239 IEVAKELGNRFDPRGVRLDSGDLAELSKATRAILDAAGLEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 324 PALGAVYKLVAIEDtDGKLndtikiSSNPEKITTPGLKRIYRIINRvnDHAEGDYIALdSEEPGKEERLKMFHPVhtyis 403
Cdd:PRK12484 319 PVLDSAYKLVAYEG-RGVT------KLSSGKVTYPGRKQVFRLYEH--GTACGDVIGL-HTENIPDGREPLLVPV----- 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1266811158 404 kfvtnfearelhkdiFVNGERTYELPSILDIQQYSAQSLALFWEEYMRTLNPEEYPVDLSQECW 467
Cdd:PRK12484 384 ---------------MTNGRRIQHAPTLDGARDWCEAQLAALPPEARRLVDPVAVSVTLSGELA 432
|
|
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
10-468 |
2.06e-136 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 404.42 E-value: 2.06e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 10 ALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQ---FEEEFLH 86
Cdd:PLN02885 12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMpsgCEDAFFD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 87 YLQNMKFTGT-IRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAA-SNDELLEFGTRRAH 164
Cdd:PLN02885 92 YLRGLDCSDVeVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAgKSKVLLEFGLRRAQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 165 EFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYR--DEyVAFKK--YAETHKKC-------------- 226
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMglDE-IVDKTlrSADGSSVCedfvslvqewlskl 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 227 --------VF------------------------LVDTYDTLKSGVPNAIRVA---KEFGdridfY---GIRLDSGDMAY 268
Cdd:PLN02885 251 qessslrgVFsetnqselaaftsyalafpnsflaLVDTYDVMKSGIPNFCAVAlalNDLG-----YkavGIRLDSGDLAY 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 269 LSKKARK-------LLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSFEQPALGAVYKLVAIEDTdgk 341
Cdd:PLN02885 326 LSLEARKffrtieeELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQ--- 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 342 lnDTIKISSNPEKITTPGLKRIYRIINRvndhaEG----DYIALDSEEPGKE-ERLKMFHPVHTYISKFVTNFEARELHK 416
Cdd:PLN02885 403 --PRIKLSEDVEKVTIPCKKRCYRLYGK-----EGyplvDLMTGENEPPPKVgERILCRHPFNESKRAYVVPQRVEELLK 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1266811158 417 DIF--VNGERTYELPSILDIQQYSAQSLALFWEEYMRTLNPEEYPVDLSQECWD 468
Cdd:PLN02885 476 CYWdgSSGKPREELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKLYD 529
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
10-331 |
1.33e-121 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 359.28 E-value: 1.33e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 10 ALHTDLYQINMAYTYWKdGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL-QFEEEFLHYL 88
Cdd:cd01567 1 LLDTDLYKLTMMQAYLY-PYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLlIFGEFFLYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 89 QNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDE------------LL 156
Cdd:cd01567 80 FLGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLLetkdnleelgfkLH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 157 EFGTRRAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAY-RDEYVAFKKYAET-----HKKCVFLV 230
Cdd:cd01567 160 DFGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFgALEEAAFEAFARWlpqfgGGLGIALI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 231 DTYDTLKsGVPNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGF--TNTKIIASSDLD-EYTIMHLKSQGAK 307
Cdd:cd01567 240 DTYDTDN-GFLNALKLAKALGAGGGLLGVRLDSGDPVELIKKVRKHLDELGIdlNKKKIIISGDLDtEEAIELLLEQGAS 318
|
330 340
....*....|....*....|....*
gi 1266811158 308 -IDVWGVGTKLITSFEQPALGAVYK 331
Cdd:cd01567 319 pNDAFGVGTSLTNDLGRPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
14-331 |
1.41e-71 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 228.66 E-value: 1.41e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 14 DLYQINMAYTYwkdGIHNRRSVFDLYFRklpfENGYAVFAGLEKIVEYIENFSFtesdiaylaelqfeeeflhylqnmKF 93
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTAR----EDPYGVLAGLEEALELLELLRF------------------------PG 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 94 TGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDE--LLEFGTRRAHEfDAALW 171
Cdd:cd00516 50 PLVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKGANtkVHDFGTRKTTP-GLRLL 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 172 GTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYrDEYVAFKKYAETH-KKCVFLVDTYDTLksgVPNAIRVAKEF 250
Cdd:cd00516 129 EKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-GELAAVKALRRWLpELFIALIDVEVDT---LEEALEAAKAG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 251 GdridFYGIRLDSG-----DMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGakIDVWGVGTKLITSfeqPA 325
Cdd:cd00516 205 G----ADGIRLDSGspeelDPAVLILKARAHLDGKGLPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHSA---PP 275
|
....*.
gi 1266811158 326 LGAVYK 331
Cdd:cd00516 276 LDIVLK 281
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
11-134 |
2.26e-49 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 164.99 E-value: 2.26e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 11 LHTDLYQINMAYTYWKDGIhNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAEL--QFEEEFLHYL 88
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSlpYFKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1266811158 89 QNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVN 134
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
82-318 |
6.87e-46 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 162.06 E-value: 6.87e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 82 EEFLHYLQNMKFTgtIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTR 161
Cdd:cd01571 42 EEVLALLEGLPVK--VYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAGDKPVISFGDR 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 162 RAHEFDAALWGtRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYV-AFKKYAETHKKCVFLVDTYDTLKSGV 240
Cdd:cd01571 120 RDHPAIQPMDG-RAAYIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQVeAWKAFDETYPEDVPRIALIDTFNDEK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 241 PNAIRVAKEFGDRIdfYGIRLDS-----GDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAkiDVWGVGT 315
Cdd:cd01571 199 EEALKAAKALGDKL--DGVRLDTpssrrGVFRYLIREVRWALDIRGYKHVKIFVSGGLDEEDIKELEDVGV--DAFGVGT 274
|
...
gi 1266811158 316 KLI 318
Cdd:cd01571 275 AIS 277
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
361-468 |
4.83e-40 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 140.01 E-value: 4.83e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 361 KRIYRIINRvNDHAEGDYIALDSEE-PGKEERLKMFHPVHTYISKFVTNFEARELHKDIFVNGERTYELPSILDIQQYSA 439
Cdd:pfam17956 2 KQVYRLYDK-DGKAIADLITLADEPpPDPGEEILCFHPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQ 80
|
90 100
....*....|....*....|....*....
gi 1266811158 440 QSLALFWEEYMRTLNPEEYPVDLSQECWD 468
Cdd:pfam17956 81 EQLSRLWPEHKRLLNPHPYKVDLSEKLYQ 109
|
|
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
82-315 |
5.32e-39 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 144.63 E-value: 5.32e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 82 EEFLHYLQNMKftGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTR 161
Cdd:PRK08662 59 EEVLELLEGKP--VDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAGDKPVLSFGAR 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 162 RAHEFDAALwGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCV---FLVDTYdtlKS 238
Cdd:PRK08662 137 HVHPAIAPM-MDRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIFGDQVEAWKAFDEVVPPDVpriALVDTF---KD 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 239 GVPNAIRVAKEFGDRIdfYGIRLDS-----GDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQgakIDVWGV 313
Cdd:PRK08662 213 EREEALRAAEALGDRL--DGVRLDTpssrrGNFRKIVREVRWTLDIRGYEHVKIFVSGGLDPERIRELRDV---VDGFGV 287
|
..
gi 1266811158 314 GT 315
Cdd:PRK08662 288 GT 289
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
11-356 |
2.13e-22 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 98.47 E-value: 2.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 11 LHTDLYQINMAYTYWKD--------GIHNR-RSVFDLYFRKLpfengyavfagLEKIVEYIENFSFTESDIAYLAE--LQ 79
Cdd:cd01401 4 LDTDLYKLTMQQAVLHHypdvqvtyEFTNRsPEDFLEEAAEA-----------LREQIDHLANLRFSEEELAYLRRslPF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 80 FEEEFLHYLQNMKFtgtirsmQEGEVVFNNEPL-----LRVDAPLGEAQIIETALLNIVN---------------YQTLI 139
Cdd:cd01401 73 LKPDYLDYLELFRL-------NPEEVVVRLDTGkgqldIRISGPWKDTILYEVPLLAIVSevyfrfrdadwdyeeQLEKL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 140 ATKAARMKHAASNDEL-----LEFGTRRAHEFDAALW---GTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQA--- 208
Cdd:cd01401 146 EEKLERLLEEAKRRDLngfrfSDFGTRRRFSYEVQETvlkGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAhqa 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 209 ----YRD-EYVAFKKYAETHKK--CVFLVDTYDT---LKSgvpnairVAKEFGDRidFYGIRLDSGDMAYLSKKARKLLD 278
Cdd:cd01401 226 ltgdLKDsQKAALERWVREYGGdlGIALTDTFGTdafLRD-------FDLYFAKL--FDGVRHDSGDPFEWGEKAIAHYE 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 279 EAGF-TNTKIIASSD-LDEYTIMHLK--SQGAKIDVWGVGTKLITSFEQ----PALGAVYKLVAIEDtdgklNDTIKISS 350
Cdd:cd01401 297 KLGIdPKTKTLVFSDgLDVEKALELYeyFKGRIKVSFGIGTNLTNDFGNkeksTPLNIVIKLVECNG-----RPVAKISD 371
|
....*.
gi 1266811158 351 NPEKIT 356
Cdd:cd01401 372 SPGKNM 377
|
|
| PRK07188 |
PRK07188 |
nicotinate phosphoribosyltransferase; Provisional |
96-318 |
2.75e-20 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235953 [Multi-domain] Cd Length: 352 Bit Score: 91.93 E-value: 2.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 96 TIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAHEFDAALWGtRA 175
Cdd:PRK07188 73 KIRYLKDGDIINPFETVLEIEGPYENFGFLEGIIDGILARRTSVATNAYNVVQAANEKPVIFMGDRADHYLQQAGDG-YA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 176 AFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYV-AFKKYAET--HKKCVFLVDtYDTlkSGVPNAIRVAKEFGD 252
Cdd:PRK07188 152 AYIGGISAFSTHAQNEWWGKSGFGTMPHALIQMFNGDVVeACKAYHKTfpEDELIALVD-YNN--DVITDSLKVAREFGD 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 253 RIdfYGIRLD-SGDMA---------------------YLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDV 310
Cdd:PRK07188 229 KL--KGVRVDtSKNMIdkyfirhpevlgtfdprgvnpELIKALRKALDENGGKHVKIIVSSGFDAKKIREFEAQNVPVDI 306
|
....*...
gi 1266811158 311 WGVGTKLI 318
Cdd:PRK07188 307 YGVGSSLL 314
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
11-358 |
2.00e-16 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 80.96 E-value: 2.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 11 LHTDLYQINMAYTYWkdgiHNRRSVfDLYFRklpFEN-GYAVFAG-----LEKIVEYIENFSFTESDIAYLAELQF-EEE 83
Cdd:PRK05321 13 LDTDFYKLTMQQAVL----HHYPDA-QVEYE---FICrNDEVDLAeyideIREQLDHLCTLRLTDDELDYLRGLPFfKPD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 84 FLHYLQNMKFtgtirSMQEGEVVFNNEPL-LRVDAPLGEAQIIETALLNIVN---------------YQTLIATKAARMK 147
Cdd:PRK05321 85 FLDWLRLFRL-----NPYEVTVSIDDGQLdIRIEGPWLETILWEVPLLAIISelyfrarspevlyaqAKRRLWEKIELLK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 148 HAASNDELL--EFGTRRAHEFDAALW-------GTRAAFIGgfssTSNVRAGKRFGIPVAGTHAHSFVQAY-------RD 211
Cdd:PRK05321 160 ALPDLSGFKiaDFGTRRRFSFEWQEEvvealkeGLPGAFVG----TSNVHLAMKLGLTPIGTMAHEWFMAHqalgprlRD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 212 -EYVAFKKYAETHKK--CVFLVDTYDT---LKsgvpnaiRVAKEFGDriDFYGIRLDSGDMAYLSKKA----RKL-LDea 280
Cdd:PRK05321 236 sQYAALEDWVREYRGdlGIALTDTIGMdafLR-------DFDLYFAK--LFDGLRHDSGDPIEWGEKAiahyEKLgID-- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 281 gfTNTK-IIASSDLDEYTIMHLKSQGA-KIDV-WGVGTKLITSFEQ-PALGAVYKLVAIedtDGKlnDTIKISSNPEKIT 356
Cdd:PRK05321 305 --PRTKtLVFSDGLDFDKALELYRHFKgRIKLsFGIGTNLTNDFPGvKPLNIVIKLVEC---NGR--PVAKLSDSPGKTM 377
|
..
gi 1266811158 357 TP 358
Cdd:PRK05321 378 CD 379
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
11-357 |
6.99e-15 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 76.34 E-value: 6.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 11 LHTDLYQINMAYTYwkdgIHNRRSVFDLY-FRKLPFENGYAVFA-GLEKIVEYIENFSFTESDIAYL-AELQF-EEEFLH 86
Cdd:TIGR01514 6 LDTDLYKITMHQAV----FHNFPDVHVTYeFICRSSQLFLKEAAeALREEISALGNLRFTDDEIEYLkQELPYlKSDYID 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 87 YLQNMKFtgtiRSMQEGEVVFNNEPLL--RVDAPLGEAQIIETALLNIVN---YQTLIA------------TKAARMKHA 149
Cdd:TIGR01514 82 YLRNFRF----HPEEQVEVGIDDKGKLdiRISGSWRDTILYEIPLLAIISelyFRFRDAeadyeqqlevleSKLDQLKAE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 150 ASNDE-------LLEFGTRRAHEF---DAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQA------YRD-E 212
Cdd:TIGR01514 158 IAAETmfengfrFSEFGTRRRFSLevqDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGhqaiseYRNaQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 213 YVAFKKYAETH--KKCVFLVDTYDT---LKSgvpnairVAKEFGDRIDfyGIRLDSGDMAYLSKKARKLLDEAGF-TNTK 286
Cdd:TIGR01514 238 KVALECWINEYdgDLGIALTDTFTTdafLRD-------FRPPFADAYD--GLRHDSGDPVEWGDKAIAHYQKLGIdPKSK 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1266811158 287 IIASSD-LD---EYTIMHLKSQGAKIDvWGVGTKLITSFEQ-PALGAVYKLVAIedtdgKLNDTIKISSNPEKITT 357
Cdd:TIGR01514 309 IIIFSDsLDvekAIELSHYFKGRVKAS-FGIGTNLTNDFGKvEPLNIVIKLVEC-----NGNPVAKLSDSPGKTMG 378
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
155-354 |
9.98e-13 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 67.79 E-value: 9.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 155 LLEFGTRRAHEFDAALWGTRAAFiGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYR--------------DEYVA-FKKY 219
Cdd:pfam04095 3 LHDFGTRRRSSLESQEIVGLAHL-VNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQeldanlrqfqkdalDLWHAeYRGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 220 AETHKKCVFLVDtyDTLKSGVPNAIRVakefgdridFYGIRLDSGD----MAYLSKKARKLLDEAGFTNTkIIASSDLDE 295
Cdd:pfam04095 82 LGIALTDTVTMD--AFLKDFDLYFAKL---------YLGVRPDSGDpvewGEKLIAHYGSTLNIDGYTKR-LIFSDGLDV 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1266811158 296 YTIM----HLKSQGAKIdVWGVGTKLITSFEQPALGAVYKLVAIeDTDGKL-----NDTIKISSNPEK 354
Cdd:pfam04095 150 EKIIelleYFKGKGFNI-AFGIGTNLTQDLNRDTLGFAVKATPL-NIVIKLvevngDPVAKISDSSGK 215
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
46-417 |
4.78e-03 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 39.49 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 46 ENGYAVFAGLEKIV-EYIENfSFTESDIAYlAELQF--------EEEFLHYLQNM--KFTGTIRSMQEGEVVFNNEPLLR 114
Cdd:PRK09198 40 RYDKVVFFGLQYFLkEYLIQ-PITEAFIDE-AKALLvahglpfnRAGWRRIVDKYggYLPLRIKAVPEGSVVPVHNVLMT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 115 VDAPLGE----AQIIETALLNIVNYQTLIATKAARMKHA--------ASNDELLEFgtrRAHEF---------DAALWGt 173
Cdd:PRK09198 118 IENTDPEffwlPNYLETLLLRNVWYPSTVATISWEYKQLirqylektADDLDFLPF---QLHDFgargmssleSAALGG- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 174 rAAFIGGFSSTSNVRAG---KR--------FGIPVAgthAHSFVQAY-RD-EYVAFKKYAETHKKCVFL---VDTYDTLk 237
Cdd:PRK09198 194 -AAHLVSFLGTDTIPALlyaERyynadmagFSIPAT---EHSVMTSWgREgELEAYRNMIEQFYPGGIVsivSDSYDLW- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 238 sgvpNAIRVA--KEFGDRIDFYG----IRLDSGDMAYLSKKARKLLDEA-GFT-NTK----------IIASSDLDEYTIM 299
Cdd:PRK09198 269 ----NAITEPwgGELKDEILARGgtlvIRPDSGDPVTIICGTLELLDEIfGGTvNSKgykvlnphvgVIQGDGITLDSIE 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 300 H----LKSQGAKID--VWGVGTKLITSFEQPALGAVYKLVAIEDtDGKLNDtikISSNPekITTPGLK----RIYRIINr 369
Cdd:PRK09198 345 AileaLKAKGFAAEniVFGMGGALLQYVNRDTQGFAMKASAIEV-NGEWRD---IFKDP--ITDQGKKskkgRLKLIKD- 417
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1266811158 370 vndhaEGDYIALDSEEPGKEERlkmfhpvhtyiSKFVTNFEARELHKD 417
Cdd:PRK09198 418 -----NGEYRTVDLDEAGDEND-----------DLLQTVFENGKLLVE 449
|
|
| nadV |
PHA02594 |
nicotinamide phosphoribosyl transferase; Provisional |
97-286 |
7.43e-03 |
|
nicotinamide phosphoribosyl transferase; Provisional
Pssm-ID: 222898 [Multi-domain] Cd Length: 470 Bit Score: 38.86 E-value: 7.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 97 IRSMQEGEVVFNNEPLLRVDAPLGE----AQIIETALLNIVNYQTLIATKAARMK-----HAA--SNDELLEFGTRrAHE 165
Cdd:PHA02594 103 VRAVPEGTVVPVKVPVLTIENTHPDffwlAGYLETVILRGVWYPSTVATLSRECKkilkkYLKetSDNEDEVLDFQ-LHD 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266811158 166 F---------DAALWGtrAAFIGGFSSTSNVRA------------GKRFGIPVAGTHaHSFVQAY--RDEYVAFKKYAET 222
Cdd:PHA02594 182 FgargmssgeSAALGG--LAHLYNFKGTDTVEAlymakryygddeVEMAGISVPARE-HSTMCSYgaENEDEAFKNSLTL 258
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1266811158 223 HKKCVFLV--DTYDtLKSGVPnaiRVAKEFGDRIDFYG----IRLDSGDMAYLSKKARKLLDE--AGFTNTK 286
Cdd:PHA02594 259 YGTGIYSIvsDTYD-FKRAVT---EILPELKDEIMARGgklvIRPDSGDPVDIICGALETLGEifGGTVNSK 326
|
|
| |
