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Conserved domains on  [gi|1266890499|gb|PHH25692|]
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transcriptional regulator NanR [Raoultella planticola]

Protein Classification

transcriptional regulator NanR( domain architecture ID 11480059)

transcriptional regulator NanR is an HTH-type transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 19-260 3.50e-144

transcriptional regulator NanR; Provisional


:

Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 403.63  E-value: 3.50e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  19 GNSLHRRPLARKKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRP 98
Cdd:PRK03837    1 GRNLRSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  99 SADTIIGELSGMAKDFLS-HPGGIAHFEQLRLFFESSLVRYAAEHASDEQVAKLEQALKINSQSLDDNALFIRSDVEFHR 177
Cdd:PRK03837   81 SADTIIGQLSGMAKDFLSqSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 178 VLAEIPGNPIFLAIHVALLDWLIAARPTVPehELHEHNNVSYQQHIDIVDAIRRHDPDEADRALQTHLNSVSATWHAFGQ 257
Cdd:PRK03837  161 VIAEIPGNPIFMAIHEALLDWLIEARPEVV--ILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSALYHALGQ 238


                  ...
gi 1266890499 258 KKQ 260
Cdd:PRK03837  239 TTN 241
 
Name Accession Description Interval E-value
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 19-260 3.50e-144

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 403.63  E-value: 3.50e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  19 GNSLHRRPLARKKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRP 98
Cdd:PRK03837    1 GRNLRSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  99 SADTIIGELSGMAKDFLS-HPGGIAHFEQLRLFFESSLVRYAAEHASDEQVAKLEQALKINSQSLDDNALFIRSDVEFHR 177
Cdd:PRK03837   81 SADTIIGQLSGMAKDFLSqSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 178 VLAEIPGNPIFLAIHVALLDWLIAARPTVPehELHEHNNVSYQQHIDIVDAIRRHDPDEADRALQTHLNSVSATWHAFGQ 257
Cdd:PRK03837  161 VIAEIPGNPIFMAIHEALLDWLIEARPEVV--ILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSALYHALGQ 238


                  ...
gi 1266890499 258 KKQ 260
Cdd:PRK03837  239 TTN 241
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
25-254 1.67e-56

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 180.51  E-value: 1.67e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  25 RPLARKKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTII 104
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 105 GELSGMakdFLSHPGGIAHFEQLRLFFESSLVRYAAEHASDEQVAKLEQALKINSQSLDDNALFIRSDVEFHRVLAEIPG 184
Cdd:COG2186    81 DPLALL---LALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASG 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1266890499 185 NPIFLAIHVALLDWLIAARP-TVPEHELHEHnnvSYQQHIDIVDAIRRHDPDEADRALQTHLNSVSATWHA 254
Cdd:COG2186   158 NPLLALLLESLRELLRRSVRlTLRSPEARER---SLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLRE 225
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 32-95 4.53e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 78.43  E-value: 4.53e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1266890499  32 LSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARV 95
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 126-247 5.83e-19

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 80.10  E-value: 5.83e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  126 QLRLFFESSLVRYAAEHASDEQVAKLEQAL---KINSQSLDDNALFIRSDVEFHRVLAEIPGNPIFLAIHVALLDWLIAA 202
Cdd:smart00895   4 EVRRALEPLAARLAAERATDEDLAALEALLdamEAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRL 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1266890499  203 RPTVPEHELHEHnnvsyQQHIDIVDAIRRHDPDEADRALQTHLNS 247
Cdd:smart00895  84 RRLSLEAARRAL-----DEHRAILDAIRARDAEAARAAMREHLEA 123
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 31-96 3.20e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 70.94  E-value: 3.20e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1266890499  31 KLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVS 96
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 19-260 3.50e-144

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 403.63  E-value: 3.50e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  19 GNSLHRRPLARKKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRP 98
Cdd:PRK03837    1 GRNLRSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  99 SADTIIGELSGMAKDFLS-HPGGIAHFEQLRLFFESSLVRYAAEHASDEQVAKLEQALKINSQSLDDNALFIRSDVEFHR 177
Cdd:PRK03837   81 SADTIIGQLSGMAKDFLSqSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 178 VLAEIPGNPIFLAIHVALLDWLIAARPTVPehELHEHNNVSYQQHIDIVDAIRRHDPDEADRALQTHLNSVSATWHAFGQ 257
Cdd:PRK03837  161 VIAEIPGNPIFMAIHEALLDWLIEARPEVV--ILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSALYHALGQ 238


                  ...
gi 1266890499 258 KKQ 260
Cdd:PRK03837  239 TTN 241
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
25-254 1.67e-56

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 180.51  E-value: 1.67e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  25 RPLARKKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTII 104
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 105 GELSGMakdFLSHPGGIAHFEQLRLFFESSLVRYAAEHASDEQVAKLEQALKINSQSLDDNALFIRSDVEFHRVLAEIPG 184
Cdd:COG2186    81 DPLALL---LALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASG 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1266890499 185 NPIFLAIHVALLDWLIAARP-TVPEHELHEHnnvSYQQHIDIVDAIRRHDPDEADRALQTHLNSVSATWHA 254
Cdd:COG2186   158 NPLLALLLESLRELLRRSVRlTLRSPEARER---SLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLRE 225
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
23-251 1.56e-31

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 115.79  E-value: 1.56e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  23 HRRPLARKKLSEMVEEELENMIRRREFAEGEQLpSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADT 102
Cdd:COG1802     3 SPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 103 IIgELSgmakdflshpggiahfeQLRLFFESSLVRYAAEHASDEQVAKLEQALKINSQSLD--DNALFIRSDVEFHRVLA 180
Cdd:COG1802    82 IR-ELY-----------------EVRAALEGLAARLAAERATPADLARLRALLEELEAAAAagDVAAYLELDREFHRALV 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1266890499 181 EIPGNPIFLAIHVALLDWLIAARPTVpeHELHEHNNVSYQQHIDIVDAIRRHDPDEADRALQTHLNSVSAT 251
Cdd:COG1802   144 EAAGNPRLAELLRRLRARLRRYRRLS--LRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARER 212
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 32-95 4.53e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 78.43  E-value: 4.53e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1266890499  32 LSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARV 95
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 126-247 5.83e-19

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 80.10  E-value: 5.83e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  126 QLRLFFESSLVRYAAEHASDEQVAKLEQAL---KINSQSLDDNALFIRSDVEFHRVLAEIPGNPIFLAIHVALLDWLIAA 202
Cdd:smart00895   4 EVRRALEPLAARLAAERATDEDLAALEALLdamEAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRL 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1266890499  203 RPTVPEHELHEHnnvsyQQHIDIVDAIRRHDPDEADRALQTHLNS 247
Cdd:smart00895  84 RRLSLEAARRAL-----DEHRAILDAIRARDAEAARAAMREHLEA 123
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 30-263 3.46e-18

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 81.35  E-value: 3.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  30 KKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGE----RARVSRPSADTIIG 105
Cdd:PRK10421    1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGgtfiRWRHETWSEQNIVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 106 ELSG-MAKDflshPGGIAHFEQLRLFFESSLVRYAAEHASDEQVAKLEQALkiNSQSLDDNALFIRSDVEFHRVLAEIPG 184
Cdd:PRK10421   81 PLKTlMADD----PDYSFDILEARHAIEASTAWHAAMRATPGDKEKIQLCF--EATLSEDPDLASQADVRFHLAIAEASH 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 185 NPIFLAIHVALLDWLIAarpTVPE--HELHEHNNVSYQ---QHIDIVDAIRRHDPDEADRALQTHLNSVSATWHAFGQKK 259
Cdd:PRK10421  155 NVVLLQTMRGFFDVLQS---SVKQsrQRMYLVPPVFSQlteQHQAVMDAILAGDAEGARKAMMAHLSFVHTTIKRFDEDQ 231


                  ....
gi 1266890499 260 QSRK 263
Cdd:PRK10421  232 ARQA 235
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
36-95 7.51e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 75.30  E-value: 7.51e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499   36 VEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARV 95
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 31-96 3.20e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 70.94  E-value: 3.20e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1266890499  31 KLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVS 96
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
32-246 7.56e-16

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 74.51  E-value: 7.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  32 LSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIIGELSGMA 111
Cdd:COG2188     6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 112 KDFLSHpgGIAHfeqlrlffESSLVRYAAEHASDEQVAKLEqalkinsqsLDDNALFIRsdveFHRVLaEIPGNPIFLAI 191
Cdd:COG2188    86 EELRAR--GREP--------STRVLSAERVPADEEVAEALG---------LPPGAPVLR----IERLR-LADGEPVALET 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1266890499 192 HvalldWLIAAR-PTVPEHELHEHNNVSY---QQHIDIVDAIRRHDPDEADRALQTHLN 246
Cdd:COG2188   142 S-----YLPAALfPGLLEEDLETGSLYELleeRYGLRITRAEQRIEAVLADAEEAELLG 195
PRK10225 PRK10225
Uxu operon transcriptional regulator;
40-248 3.36e-15

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 73.13  E-value: 3.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  40 LENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTiigELSGMAKDFLSHPG 119
Cdd:PRK10225   18 IRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH---NTDSPDANVCNDAG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 120 GiahFEQL--RLFFESSLVRYAAEHASDEQVAKLEQALKINSQSLDDNAL--FIRSDVEFHRVLAEIPGNPIFLAIHVAL 195
Cdd:PRK10225   95 P---FELLqaRQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPgsSESGDMQFHLAIAEATHNSMLVELFRQS 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 196 LDWliaaRPTVPEH-ELHEH-NNVSYQQ-----HIDIVDAIRRHDPDEADRALQTHLNSV 248
Cdd:PRK10225  172 WQW----RENNPMWiQLHSHlDDSLYRKewlgdHKQILAALIKKDARAAKLAMWQHLENV 227
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 126-242 6.37e-15

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 69.32  E-value: 6.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 126 QLRLFFESSLVRYAAEHASDEQVAKLEQALK--INSQSLDDNALFIRSDVEFHRVLAEIPGNPIFLAIHVALLDWLIAAR 203
Cdd:pfam07729   4 ELRAALEPLAARLAAERATDEDLAELEALLEalEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRLR 83

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1266890499 204 PTVPEHElhEHNNVSYQQHIDIVDAIRRHDPDEADRALQ 242
Cdd:pfam07729  84 RLLLSSP--GRLRASLEEHRAILDAIRARDPEAARAAMR 120
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
31-245 4.26e-13

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 66.97  E-value: 4.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  31 KLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVS----RPSADTIIGE 106
Cdd:PRK09464   10 KLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQsslwQSFSDPLVEL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 107 LSgmakdflSHPGGIAHFEQLRLFFESSLVRYAAEHASDEQVAKLEQALKINSQSLDDNALFIRSD--VEFHRVLAEIPG 184
Cdd:PRK09464   90 LS-------DHPESQFDLLETRHALEGIAAYYAALRGTDEDFERIRECHHAIELAQQSGDLDAEANavMQYQIAVTEAAH 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 185 NpiflaihVALLDWLIAARPTVPEHE------LHEHNNVSYQ--QH-IDIVDAIRRHDPDEADRALQTHL 245
Cdd:PRK09464  163 N-------VVLLHLLRCMEPMLEQNVrqnfelLYRRREMLPKvsSHrARIFEAIVAGKPEKAREASHRHL 225
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 28-260 1.28e-10

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 60.17  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  28 ARKKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTiigEL 107
Cdd:PRK09990    4 ERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQ---DA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 108 SGMAKDFLSHPGGIAHFEQLRLFFESSLVRYAAEHASDEQVAKL----EQALKINSQSLD-DNALFIRSDVEFHRVLAEI 182
Cdd:PRK09990   81 SPLMHLFSSQPRTLYDLLEVRALLEGESARLAALRGTQADFVLItrryEEMLAAHENNKEiDPIEHARLDHAFHLAICEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 183 PGNPIFLAIHVALLDWLIAARPTVPEHELHE--HNNVSYQQHIDIVDAIRRHDPDEADRALQTHLNSVSATWHAFGQKKQ 260
Cdd:PRK09990  161 SHNPVLVHTLQSLTDLMLSSVFASVNNLYHRpqQKKQIDRQHARLYNAVLQRLPEQAQRAARDHIRTVRDNLREIEQEEQ 240
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 28-86 6.10e-06

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 46.75  E-value: 6.10e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1266890499  28 ARKKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQ 86
Cdd:COG1167     9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIE 67
PRK11523 PRK11523
transcriptional regulator ExuR;
30-245 1.00e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 45.61  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  30 KKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARV--SRPSADTIigel 107
Cdd:PRK11523    7 RRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVvsNQPRHQQA---- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499 108 SGMAKDFLSHpgGIAHFEQLRLFFESSLVRYAAEHASDEQVAKLeQALKINSQSlDDNALFIRSDVEFHRVLAEIPGNPI 187
Cdd:PRK11523   83 ADNNMEFANY--GPFELLQARQLIESNIAEFAATQVTKQDIMKL-MAIQEQARG-EDCFRDSEWDLQFHVQVALATQNSA 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1266890499 188 FLAIhvalLDWLIAARPTVPE-HELHEHNN----VSY-QQHIDIVDAIRRHDPDEADRALQTHL 245
Cdd:PRK11523  159 LAAI----VEKMWTQRSHNPYwKKLHEHIDdrtvDNWcDDHDQILKALIRKDPHAAKLAMWQHL 218
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
38-85 5.07e-05

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 41.70  E-value: 5.07e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1266890499  38 EELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLV 85
Cdd:COG1725    17 DQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLI 64
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
49-191 6.68e-05

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 42.94  E-value: 6.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  49 FAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRpsadtiIGELSG------MAKdfLSH---PG 119
Cdd:PRK04984   25 FPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNN------FWETSGlniletLAR--LDHdsvPQ 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1266890499 120 GIAHFEQLRLFFESSLVRYAAEHASDEQVAKLEQAlkinsQSLDDNA-LFIRSDVEFHRVLAEIPGNPIFLAI 191
Cdd:PRK04984   97 LIDNLLSARTNISAIFIRTAFRNNPEKALEVLATA-----EELEDTAeAFAEFDYNLFRGLAFASGNPIYGLI 164
PRK11402 PRK11402
transcriptional regulator PhoB;
36-119 1.00e-03

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 39.43  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1266890499  36 VEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIIGELSGMAkDFL 115
Cdd:PRK11402   14 VRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFT-DFG 92


                  ....
gi 1266890499 116 SHPG 119
Cdd:PRK11402   93 VSQG 96
PRK09764 PRK09764
GntR family transcriptional regulator;
27-79 2.17e-03

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 38.66  E-value: 2.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1266890499  27 LARKKLSEMVEEELENMIRRREFAEGEQLPSERELMTFFNVGRPSVREALAAL 79
Cdd:PRK09764    1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQL 53
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 22-90 6.88e-03

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 37.06  E-value: 6.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1266890499  22 LHRRPLARKKLSEMVEEELENMIRRReFAEGEQLPSERELMTFFNVGRPSVREALAALKRKGLVQINNG 90
Cdd:PRK10079    3 LSRHPTSYPTRYQEIAAKLEQELRQH-YRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQG 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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