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Conserved domains on  [gi|1273521576|gb|PIC25599|]
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hypothetical protein B9Z55_018473 [Caenorhabditis nigoni]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 1-276 7.16e-110

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10319:

Pssm-ID: 419896  Cd Length: 310  Bit Score: 320.73  E-value: 7.16e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576   1 MYVNWLHYSIPKISFVLSFISNPVFIYLICSNKKVLFGSYRYLLVFFAVFNLCASVADLLIPVSVFCYHYAFVTWVVEGP 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576  81 FSVRSEYGEIPLSFRCSFIAGTYGILNIHFVFRFLTLKSNNIINDYFMPYGLIFSIAYVIFHMFIWSLIDFYCLHSAPEM 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576 161 RDYIRLPFKELYNESISDVNFVAGLFS----------------------------------IVTGLNIKSITMSRQTTQM 206
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWeasdetvfrswlgillltvisvysiilyivlgykIMRKLNKMSVTMSKKTKRL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576 207 QKQLFKALAIQTIIPICVSFMPCSLSFYGAALRIDFMNWVYWASAVAVSMFPFLDPMAIIFFLPALRRRI 276
Cdd:pfam10319 241 QKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-276 7.16e-110

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 320.73  E-value: 7.16e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576   1 MYVNWLHYSIPKISFVLSFISNPVFIYLICSNKKVLFGSYRYLLVFFAVFNLCASVADLLIPVSVFCYHYAFVTWVVEGP 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576  81 FSVRSEYGEIPLSFRCSFIAGTYGILNIHFVFRFLTLKSNNIINDYFMPYGLIFSIAYVIFHMFIWSLIDFYCLHSAPEM 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576 161 RDYIRLPFKELYNESISDVNFVAGLFS----------------------------------IVTGLNIKSITMSRQTTQM 206
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWeasdetvfrswlgillltvisvysiilyivlgykIMRKLNKMSVTMSKKTKRL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576 207 QKQLFKALAIQTIIPICVSFMPCSLSFYGAALRIDFMNWVYWASAVAVSMFPFLDPMAIIFFLPALRRRI 276
Cdd:pfam10319 241 QKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-276 7.16e-110

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 320.73  E-value: 7.16e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576   1 MYVNWLHYSIPKISFVLSFISNPVFIYLICSNKKVLFGSYRYLLVFFAVFNLCASVADLLIPVSVFCYHYAFVTWVVEGP 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576  81 FSVRSEYGEIPLSFRCSFIAGTYGILNIHFVFRFLTLKSNNIINDYFMPYGLIFSIAYVIFHMFIWSLIDFYCLHSAPEM 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576 161 RDYIRLPFKELYNESISDVNFVAGLFS----------------------------------IVTGLNIKSITMSRQTTQM 206
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWeasdetvfrswlgillltvisvysiilyivlgykIMRKLNKMSVTMSKKTKRL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576 207 QKQLFKALAIQTIIPICVSFMPCSLSFYGAALRIDFMNWVYWASAVAVSMFPFLDPMAIIFFLPALRRRI 276
Cdd:pfam10319 241 QKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-276 1.05e-36

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 132.96  E-value: 1.05e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576   8 YSIPKISFVLSFISNPVFIYLICSNKKVLFGSYRYLLVFFAVFNLCASVADLLIPVSVFCYHYAFVTWVVEGPFSVRSEY 87
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576  88 GEIPLSFRCSFIAGTYGILNIHFVFRFLTLKSNNIINdYFMPYGLIFSIAYVIFHMFIWSLIDFYCLHSAPEMRDYIRLP 167
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLK-YFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576 168 FKELYNESISDVNFVA--------------------GLFSIVTGLNIKSITM------------------SRQTTQMQKQ 209
Cdd:pfam10326 161 LLENYNLDIDEVAYVGpvyyptdengskvirwrsliGLLIMTFIIGISFSIIiycgikmyfkmkklkslgSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1273521576 210 LFKALAIQTIIPICVSFMPCSLSFYGAALRIDFMNWVYWASAvAVSMFPFLDPMAIIFFLPALRRRI 276
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITA-TIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 13-277 2.17e-06

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 48.32  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576  13 ISFVLSFISNPVFIYLICSNKKVLFGSYRYLLVFFAVFNLCASVADLLI---------PVSVFCYhyAFVTWVveGPFSV 83
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTqqriipngvSMALISY--GPCKYF--GPWFC 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576  84 RSEYgeiplSFRCSFIAGTYGILNIHFVFRFLTLKSNNIINDYFMPYGLIFSIAYVIFHMFIWSLIDFyclHSAPEMRDY 163
Cdd:pfam10317  83 YSGY-----SLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTD---FLPVEALTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273521576 164 IRLPFKELYNESI---SDVNFVAGLFSIVT---------------------GLNIKSITMSRQTTQMQKQLFKALAIQTI 219
Cdd:pfam10317 155 ELHPNYNLTDYTVtgfSDLQSFPALINTLImtipvfpipiiililrrkilkLLNSNSVNMSPTTKAQHRQLIKGLTIQAL 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1273521576 220 IPICVSFMPCSLSFYGAALRIDFMNWVYwASAVAVSMFPFLDPMAIIFFLPALRRRIM 277
Cdd:pfam10317 235 LPLFSYIPGVTLYLLSQLTGTEFLILEY-FIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 192-234 2.86e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 41.76  E-value: 2.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1273521576 192 LNIKSITMSRQTTQMQKQLFKALAIQTIIPICVSFMPCSLSFY 234
Cdd:pfam10318 213 FKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILF 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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