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Conserved domains on  [gi|1277777458|gb|PIT94054|]
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hypothetical protein COU00_01155 [Candidatus Falkowbacteria bacterium CG10_big_fil_rev_8_21_14_0_10_43_11]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
class_II_aaRS-like_core super family cl00268
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ...
 2-51 1.73e-06

Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.


The actual alignment was detected with superfamily member PLN02502:

Pssm-ID: 444800 [Multi-domain]  Cd Length: 553  Bit Score: 42.67  E-value: 1.73e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1277777458   2 QQQSKQSAPINSSAGKRNEY-EDRLKKLELLKQTGVNPYPAKIERDFTIGD 51
Cdd:PLN02502   42 KGRSRKSAAADDETMDPTQYrANRLKKVEALRAKGVEPYPYKFDVTHTAPE 92
 
Name Accession Description Interval E-value
PLN02502 PLN02502
lysyl-tRNA synthetase
 2-51 1.73e-06

lysyl-tRNA synthetase


Pssm-ID: 215278 [Multi-domain]  Cd Length: 553  Bit Score: 42.67  E-value: 1.73e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1277777458   2 QQQSKQSAPINSSAGKRNEY-EDRLKKLELLKQTGVNPYPAKIERDFTIGD 51
Cdd:PLN02502   42 KGRSRKSAAADDETMDPTQYrANRLKKVEALRAKGVEPYPYKFDVTHTAPE 92
 
Name Accession Description Interval E-value
PLN02502 PLN02502
lysyl-tRNA synthetase
 2-51 1.73e-06

lysyl-tRNA synthetase


Pssm-ID: 215278 [Multi-domain]  Cd Length: 553  Bit Score: 42.67  E-value: 1.73e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1277777458   2 QQQSKQSAPINSSAGKRNEY-EDRLKKLELLKQTGVNPYPAKIERDFTIGD 51
Cdd:PLN02502   42 KGRSRKSAAADDETMDPTQYrANRLKKVEALRAKGVEPYPYKFDVTHTAPE 92
lysS PRK00484
lysyl-tRNA synthetase; Reviewed
 19-54 3.11e-06

lysyl-tRNA synthetase; Reviewed


Pssm-ID: 234778 [Multi-domain]  Cd Length: 491  Bit Score: 42.00  E-value: 3.11e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1277777458  19 NEYED-RLKKLELLKQTGVNPYPAKIERDFTIGDVLN 54
Cdd:PRK00484    4 NEQIAvRREKLAELREQGIDPYPNKFERTHTAAELRA 40
lysS PRK02983
bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX;
24-54 6.81e-04

bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX;


Pssm-ID: 235095 [Multi-domain]  Cd Length: 1094  Bit Score: 35.32  E-value: 6.81e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1277777458   24 RLKKLELLKQTGVNPYPAKIERDFTIGDVLN 54
Cdd:PRK02983   617 RLAKLEALRAAGVDPYPVGVPPTHTVAEALD 647
PTZ00417 PTZ00417
lysine-tRNA ligase; Provisional
 6-49 7.75e-04

lysine-tRNA ligase; Provisional


Pssm-ID: 173607 [Multi-domain]  Cd Length: 585  Bit Score: 35.37  E-value: 7.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1277777458   6 KQSAPINSSAGKRNE----------YEDRLKKLELLKQTGVNPYPAKIERDFTI 49
Cdd:PTZ00417   61 KKVRSVQASKDKKKEeeaevdprlyYENRSKFIQEQKAKGINPYPHKFERTITV 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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