|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
1-815 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 926.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 1 FKIVPQCPHCETPLSSHELalGYADVHDPSVYIKFKLND-------ENASILAWTTTPWTLISNVALAVGSQIDYVKIKT 73
Cdd:COG0060 182 LKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDekallllEDAYLVIWTTTPWTLPANLAVAVHPDIDYVLVEV 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 74 EKHGILYLAEARL-SVIK----EDYEIISHLKGADLLNKEYEPLFSYIPTDKKGWYVVPGDFVSTEDGTGVVHIAPAFGA 148
Cdd:COG0060 260 TGGERLILAEALVeAVLKelgiEDYEVLATFKGAELEGLRYEHPFYYVVGYDRAHPVILGDYVTTEDGTGIVHTAPGHGE 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 149 DDYEVSKKFDLPFLQPVTKGGRFTSEVTDFAGRLVKSlkfttheekgVDPDVVRNLKERGLIYKAGnDHLHSYPHCWRCD 228
Cdd:COG0060 340 DDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKD----------ANPAIIEDLKERGALLARE-KITHSYPHCWRCK 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 229 NPLIYYARDSWYIRTTEISKRMIELNKTINWYPpEVGSGRFGNWLEENKDWSLSRDRYWGTPLPLWLNDEG-----DMFA 303
Cdd:COG0060 409 TPLIYRATPQWFISMDKLRDRALEAIEKVNWIP-EWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCgelhrTEEV 487
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 304 IGSVAELkegfVERDGKKILvrdlprEEIDLHKPFVDDV-TFERNGKIYKRTPELIDVWFDSGSMPFAQyhypFENQEwf 382
Cdd:COG0060 488 IGSVAEL----LEEEGADAW------FELDLHRPFLDETlKCPKCGGTMRRVPDVLDVWFDSGSMHFAV----LENRE-- 551
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 383 DKNFPADFICEGIDQTRGWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLt 462
Cdd:COG0060 552 ELHFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWV- 630
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 463 VNNPPWRPTLFSEDDLAETqRKFFGTLLNTYSFFAlyANIDKFNFSETFIPYDERPEIDRWIISKLNSVVKEYQQFMDSY 542
Cdd:COG0060 631 ASSDYWGDLRFSDEILKEV-RDVYRRLRNTYRFLL--ANLDDFDPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNY 707
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 543 DVTKAARLIYSFTIDHLSNWYVRRNRRRFWKSENNQN-KIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGntkeEP 621
Cdd:COG0060 708 DFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLdRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPG----EA 783
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 622 FESVHLSVFPE--MKIADKALEEKMELAQRVVYLTR----AMRAKlNLkVRQPLQKIMV-AVDAAKRSSLEQMRDVILEE 694
Cdd:COG0060 784 EESVHLADWPEvdEELIDEELEAKWDLVREVRSAVLkaleAARKE-KL-IRQPLEAAVVlYADEELAAALESLGDLLAEE 861
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 695 VNVKELIVLTDDAnivtksakpnfktlgpKFGKkvnpvaNAIREFDkdligklEKGESVFVtlggesfEVQKSDVEiisS 774
Cdd:COG0060 862 LNVSEVELVDDAE----------------DLGK------DALKALD-------VEGISVTV-------EVEKADGE---K 902
|
810 820 830 840
....*....|....*....|....*....|....*....|.
gi 1278124880 775 EITGWSVEsdegvtvaldtlLNDDLIQEGLAREFVNRIQNM 815
Cdd:COG0060 903 CERCWHYE------------VGWTPEHEGLCRRCVRRVQGL 931
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
1-691 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 713.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 1 FKIVPQCPHCETPLSSHELAL--GYADVHDPSVYIKFKLNDEN--------ASILAWTTTPWTLISNVALAVGSQIDYVK 70
Cdd:TIGR00392 173 LKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKktylkvklSSLLIWTTTPWTLPSNLAIAVHPDFEYAL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 71 IKTEKHGILY-LAEARLSV----IKEDYEIISHLKGADLLNKEYEPLFSYIPTDKKGWY--VVPGDFVSTEDGTGVVHIA 143
Cdd:TIGR00392 253 VQDNTKVEYFiLAKKLVEKlynkAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEGApvVIGGDHVTTEDGTGIVHTA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 144 PAFGADDYEVSKKFDLPFLQPVTKGGRFTSEVTDFAGRLVKSlkftthEEKGV---DPDVVRNLKERGLIYKAGNdHLHS 220
Cdd:TIGR00392 333 PGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFVKD------ADKDIikaNKIIIEQLKDKGLLLKAEK-ITHS 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 221 YPHCWRCDNPLIYYARDSWYIRTTEISKRMIELNKTINWYPpEVGSGRFGNWLEENKDWSLSRDRYWGTPLPLWL-NDEG 299
Cdd:TIGR00392 406 YPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVP-EWGEGRFGNWLENRPDWCISRQRYWGIPIPIWYcEDTG 484
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 300 DMFAIGSVAELKEgfverdgkKILVRDLPREEIDLHKPFVDDVTFE-RNGKIYKRTPELIDVWFDSGSMPFAQYHYPFEN 378
Cdd:TIGR00392 485 EPIVVGSIEELIE--------LIELKGIDAWFEDLHRDFLDKITLKsGDGGEYRRVPDVLDVWFDSGSMPYASIHYPFEN 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 379 qEWFDKNFPADFICEGIDQTRGWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATR 458
Cdd:TIGR00392 557 -EKFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILR 635
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 459 WYLTvNNPPWRPTLFSEDDLAETQRKFFGTLLNTYSFFALYANIDKFNFSETFIPYDERPEIDRWIISKLNSVVKEYQQF 538
Cdd:TIGR00392 636 LYVA-SSDPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTYANLDKFDPLFNSVAVEKFPEEDRWILSRLNSLVEEVNEA 714
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 539 MDSYDVTKAARLIYSFTIDHLSNWYVRRNRRRFWKSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGNTK 618
Cdd:TIGR00392 715 LEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLPGGEE 794
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278124880 619 EepfESVHLSVFPEMKIA--DKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKIMVavdaakRSSLEQMRDVI 691
Cdd:TIGR00392 795 E---ESVHLNLWPEVDEEfiDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVI------GKSLEAVLKAV 860
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
1-836 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 686.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 1 FKIVPQCPHCETPLSSHELALGYADVHDPSVYIKFKLNDE--NASILAWTTTPWTLISNVALAVGSQIDYVKIKTEKHGI 78
Cdd:PLN02882 175 FKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIVGDpdNASFVAWTTTPWTLPSNLALCVNPNFTYVKVRNKYTGK 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 79 LY-LAEARLSVI----------------KEDYEIISHLKGADLLNKEYEPLFSYIPTDKKG-WYVVPGDFVSTEDGTGVV 140
Cdd:PLN02882 255 VYiVAESRLSALptakpkskkgskpenaAEGYEVLAKVPGSSLVGKKYEPLFDYFSEFSDTaFRVVADDYVTDDSGTGVV 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 141 HIAPAFGADDYEV-------SKKFDLPflQPVTKGGRFTSEVTDFAGRLVKSlkfttheekgVDPDVVRNLKERGLIYKA 213
Cdd:PLN02882 335 HCAPAFGEDDYRVclangiiEKGGNLP--VPVDDDGCFTEKVTDFSGRYVKD----------ADKDIIAAIKAKGRLVKS 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 214 GNdHLHSYPHCWRCDNPLIYYARDSWYIRTTEISKRMIELNKTINWYPPEVGSGRFGNWLEENKDWSLSRDRYWGTPLPL 293
Cdd:PLN02882 403 GS-ITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPI 481
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 294 WLNDEG-DMFAIGSVAELKEgfveRDGKKIlvrdlpreeIDLHKPFVDDVTFE----RNGKIYKRTPELIDVWFDSGSMP 368
Cdd:PLN02882 482 WISDDGeEVVVIGSIAELEK----LSGVKV---------TDLHRHFIDHITIPssrgPEFGVLRRVDDVFDCWFESGSMP 548
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 369 FAQYHYPFENQEWFDKNFPADFICEGIDQTRGWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTL 448
Cdd:PLN02882 549 YAYIHYPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEV 628
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 449 FDKYGADATRWYLtVNNPPWR--PTLFSEDDLAETQRKFFGTLLNTYSFFALYANIDKFNFSETFIPYDERPE------I 520
Cdd:PLN02882 629 IDKYGADALRLYL-INSPVVRaePLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVPLDLAKLqnsanvL 707
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 521 DRWIISKLNSVVKEYQQFMDSYDV-TKAARLIySFtIDHLSNWYVRRNRRRFWKSENNQNKIAAYQTLYESLKIIAKLLS 599
Cdd:PLN02882 708 DRWINSATQSLVKFVREEMGAYRLyTVVPYLV-KF-IDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMA 785
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 600 PFAPFFAEELYQNLNGNTKEEPfESVHLSVFPEMKIA--DKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKIMVA-V 676
Cdd:PLN02882 786 PFTPFFTEVLYQNLRKVLPGSE-ESIHYCSFPQVDEGelDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVhP 864
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 677 DAAKRSSL-EQMRDVILEEVNVKELIVLTDDANIVTKSAKPNFKTLGPKFGKKVNPVANAIREFDKDLIGKLEKGESvfV 755
Cdd:PLN02882 865 DAEFLDDItGKLKEYVLEELNVRSLVPCNDPLKYASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGE--V 942
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 756 TLGGESFEVqkSDVEII----SSEITGW---SVESDEGVTVALDTLLNDDLIQEGLAREFVNRIQNMRKDAGFEVTDRIL 828
Cdd:PLN02882 943 TIAGHTLKA--GDIKVVrdfkRPEGVSKediDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVE 1020
|
....*...
gi 1278124880 829 ISAEAIDD 836
Cdd:PLN02882 1021 VFFESLDE 1028
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
1-818 |
1.07e-157 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 493.33 E-value: 1.07e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 1 FKIVPQCPHCETPLSSHELALGYADVHDPSVYIKFKL------------------------------------NDENAS- 43
Cdd:PTZ00427 239 FKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFVLcsdfpkveeecnieedkqllgekysvlynnkrensnNGNNNSt 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 44 ----------ILAWTTTPWTLISNVALAVGSQIDYVKI-KTEKHGILYLAEARLS-VIKE------DYEIISHLKGADLL 105
Cdd:PTZ00427 319 nnvcyaqhseILAWTTTPWTLPSNLALCVNEHFTYLRIhHVKSNRVVIVGECRLEwIMKElkwnveDLKIVNRFKGKELK 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 106 NKEYEPLFSYIPTD----KKGWYVVPGDFVSTEDGTGVVHIAPAFGADDYEVSKKFDL--P----FLQPVTKGGRFTSEV 175
Cdd:PTZ00427 399 GLRYKPLFTNFYEKynfkERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPekniFIDPLDANGYFTNEV 478
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 176 tdfagRLVKSLKFttheeKGVDPDVVRNLKERGLIYkAGNDHLHSYPHCWRCDNPLIYYARDSWYIRTTEISKRMIELNK 255
Cdd:PTZ00427 479 -----EEVQNLYI-----KEADNVIKKKLKNENRLL-SNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNE 547
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 256 TINWYPPEVGSGRFGNWLEENKDWSLSRDRYWGTPLPLWLNDEGD-MFAIGSVAELKEgfveRDGKKILVrdlpreeiDL 334
Cdd:PTZ00427 548 TTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMEtVICVESIKHLEE----LSGVKNIN--------DL 615
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 335 HKPFVDDVTFER-NGKIY---KRTPELIDVWFDSGSMPFAQYHYPFENQ-EWFDKNFPADFICEGIDQTRGWFYTLHAIS 409
Cdd:PTZ00427 616 HRHFIDHIEIKNpKGKTYpklKRIPEVFDCWFESGSMPYAKVHYPFSTEkEDFHKIFPADFIAEGLDQTRGWFYTLLVIS 695
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 410 TMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLtVNNPPWRPT--LFSEDDLAETQRKFFG 487
Cdd:PTZ00427 696 TLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYL-INSVAVRAEnlKFQEKGVNEVVKSFIL 774
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 488 TLLNTYSFFALYA------NIDKFNFSETFIpYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFtIDHLSN 561
Cdd:PTZ00427 775 PFYHSFRFFSQEVtryeclNKKQFLFNTDYI-YKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQF-IENLTN 852
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 562 WYVRRNRRRFWKSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNL--------------NGNTKEEPF----- 622
Cdd:PTZ00427 853 WYIRLNRDRMRGSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLrrvkstnehnenneTGNTKEGDLnrgvi 932
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 623 -ESVHLSVFPEMK---IADKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKIMVAVDAAKR-SSLEQMRDVILEEVNV 697
Cdd:PTZ00427 933 hKSVHFIMLPQVDekyIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYfKNFDQISNYIKEELNV 1012
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 698 KElIVLTDDANIVTKSAKPNFKTLGPKFGKKVNPVANAIREFDKDLIGKLEKGESVF---VTLGGESFEVQKSdvEIISS 774
Cdd:PTZ00427 1013 LN-VECSNDTSCLDFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITldnVTLEGDDIIIQMK--PNFQN 1089
|
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 1278124880 775 EITgwSVESDEGVTVALDTLLNDDLIQEGLAREFVNRIQNMRKD 818
Cdd:PTZ00427 1090 DNT--DIISNNYVTILMDFTTDQQLENMASARELCNHIQKMRKN 1131
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
1-461 |
4.42e-140 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 429.14 E-value: 4.42e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 1 FKIVPQCPHCETPLSshELALGYADVHDPSVYIKFKL-NDENASILAWTTTPWTLISNVALAVGSQIDYVKIKTEkhgiL 79
Cdd:pfam00133 160 KKLVNWSPALNTALS--NLEVEYKDVKGPSIHVAFPLaDDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVITGEG----Y 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 80 YLAEARLSVIKE---DYEIISHLKGADLLNKEYEPLF--SYIPtdkkgwyVVPGDFVSTEDGTGVVHIAPAFGADDYEVS 154
Cdd:pfam00133 234 ILAEALLKSLYKkgtDKKILEDFRGKELEGKEAIHPFvnREIP-------IITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 155 KKFDLPFLQPVTKGGRFTSEVTDFAGRLVKSlkfttheekgVDPDVVRNLKERGLIYKAgNDHLHSYPHCWRCDNPLIYY 234
Cdd:pfam00133 307 QRHNLEVINPVDDDGTFTEEAPDFQGVYRFD----------ARKKIVELLTEKGLLLKI-EPFTHSYPFCWRSGTPIIPR 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 235 ARDSWYIRTTEISKRMIELNKTINWYPpEVGSGRFGNWLEENKDWSLSRDRYWGTPLPLWL-NDEGDMFAIGSVAELKEG 313
Cdd:pfam00133 376 ATPQWFVRMDELADQALEAVEKVQFVP-KSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVsKDTEEVVCRGELFELVAG 454
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 314 FVERDGKKIlvrdlpreeiDLHKPFVDDVTFERNgkIYKRTPELIDVWFDSGSMPFAQYHYPFENQEWFDKNFPADFICE 393
Cdd:pfam00133 455 RFEEEGSIK----------WLHREAKDKLGYGKG--TLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLE 522
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278124880 394 GIDQTRGWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWYL 461
Cdd:pfam00133 523 GSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWL 590
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
3-775 |
3.48e-95 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 318.54 E-value: 3.48e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 3 IVPQCPHCETPLSSHELAlgYADVHDPSVYIKFKL-NDENASILAWTTTPWTLISNVALAVGSQidyvkiktekhgilyl 81
Cdd:TIGR00422 171 LVNWDPKLNTAISDIEVE--YKEVKGKLYYIRYPLaNGSKDYLVVATTRPETMFGDTAVAVHPE---------------- 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 82 aearlsviKEDYeiishlkgADLLNKEYE-PLFSY-IPtdkkgwyVVPGDFVSTEDGTGVVHIAPAFGADDYEVSKKFDL 159
Cdd:TIGR00422 233 --------DERY--------KHLIGKKVIlPLTGRkIP-------IIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNL 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 160 PFLQPVTKGGRFTSEVTDFAGrlvksLKFTTHEEKgvdpdVVRNLKERGLIYKAgNDHLHSYPHCWRCDNPLIYYARDSW 239
Cdd:TIGR00422 290 EFINILDEDGLLNENAGKYQG-----LTRFEARKK-----IVEDLKEEGLLVKI-EPHTHNVGTCWRSGTVVEPLLSKQW 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 240 YIRTTEISKRMIEL--NKTINWYPPEVGSgRFGNWLEENKDWSLSRDRYWGTPLPLWLNDEgdmfaIGSVaelkegfver 317
Cdd:TIGR00422 359 FVKVEKLADKALEAaeEGEIKFVPKRMEK-RYLNWLRNIKDWCISRQLIWGHRIPVWYCKE-----CGEV---------- 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 318 dgkkilvrDLPREEidlhkPFVDDVTFERNGKIYKRTPELIDVWFDSGSMPFAQYHYPfENQEWFDKNFPADFICEGIDQ 397
Cdd:TIGR00422 423 --------YVAKEE-----PLPDDKTNTGPSVELEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVTGYDI 488
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 398 TRGW-FYTLHAiSTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPPWRPTLFSED 476
Cdd:TIGR00422 489 IFFWvARMIFR-SLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWK 567
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 477 DLaETQRKFFGTLLNTySFFALyANIDkfNFSETFIPYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTI 556
Cdd:TIGR00422 568 RV-ESARNFLNKLWNA-SRFVL-MNLS--DDLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIW 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 557 DHLSNWYVRRNRRRFWkSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGNTkeepfESVHLSVFPEMKIA 636
Cdd:TIGR00422 643 NDFCDWYIELVKYRLY-NGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGA-----DSIMLQSYPVVDAE 716
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 637 --DKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKIMVAVDAAKRSSLEQMRDVILEEVNVKELIVLTDD--ANIVTK 712
Cdd:TIGR00422 717 fvDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKpeVTEAVV 796
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278124880 713 SAKPNFKTLGPKFG--KKVNPVANAIREFDKDligKLEKgESVFVTLGGESFeVQKSDVEIISSE 775
Cdd:TIGR00422 797 ELVPGFEIIIPVKGliNKAKELARLQKQLDKE---KKEV-IRIEGKLENEGF-VKKAPKEVIEKE 856
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
200-473 |
8.77e-93 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 296.07 E-value: 8.77e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 200 VVRNLKERGLIYKaGNDHLHsyphcWrcdnPLIYYARDSWYIRTTEISKRMIELNKTINWYPPEVGSgRFGNWLEENKDW 279
Cdd:cd00818 124 VFKQLHEKGLLYR-GYKVVP-----W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RFGNWLENRRDW 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 280 SLSRDRYWGTPLPLWlndegdmfaigsvaelkegfVERDGKKILVRdlpreeidlhkpfvddvtferngkiykRTPELID 359
Cdd:cd00818 193 CISRQRYWGTPIPVW--------------------YCEDCGEVLVR---------------------------RVPDVLD 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 360 VWFDSGSMPFAQYHYPFENqEWFDKNFPADFICEGIDQTRGWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSK 439
Cdd:cd00818 226 VWFDSGSMPYAQLHYPFEN-EDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSL 304
|
250 260 270
....*....|....*....|....*....|....
gi 1278124880 440 GNTVDPFTLFDKYGADATRWYLTVNNPPWRPTLF 473
Cdd:cd00818 305 GNYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
2-632 |
3.19e-81 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 282.43 E-value: 3.19e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 2 KIVPQCPHCETPLSSHELAlgYADVH-DPSVYIKFKLND-------------ENASILAWTTTPWTLISNVALAVGSQID 67
Cdd:PLN02843 167 KPVHWSPSSRTALAEAELE--YPEGHvSKSIYVAFPVVSpsetspeeleeflPGLSLAIWTTTPWTMPANAAVAVNDKLQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 68 YVKIKTE-----------------KHGILYLAEARLSVIKE-----------DYEIISHLKGADLLNKEYE-PLFsyipt 118
Cdd:PLN02843 245 YSVVEVQsfsedestsggnkkkrpGNVLKEQQKLFLIVATDlvpaleakwgvKLVVLKTFPGSDLEGCRYIhPLY----- 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 119 DKKGWYVVPGDFVSTEDGTGVVHIAPAFGADDYEVSKKFDLPFLQPVTKGGRFTSEVTDFAGRLVKSlkfttheeKGvDP 198
Cdd:PLN02843 320 NRESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLG--------EG-NA 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 199 DVVRNLKERGLIYKAgNDHLHSYPHCWRCDNPLIYYARDSWYIRTTEISKRMIELNKTINWYPPeVGSGRFGNWLEENKD 278
Cdd:PLN02843 391 AVVEALDEAGSLLME-EAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA-QGENRIRAMVSGRSD 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 279 WSLSRDRYWGTPLPLW---------LNDEgdmfaigSVAELKEGFVERDGK---KILVRDLPREEidlHKPFVDDvtfer 346
Cdd:PLN02843 469 WCISRQRTWGVPIPVFyhvetkeplMNEE-------TIAHVKSIVAQKGSDawwYMDVEDLLPEK---YRDKASD----- 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 347 ngkiYKRTPELIDVWFDSGSMPFAQYhypfenQEWFDKNFPADFICEGIDQTRGWFYT--LHAISTMlfDKVAYKNVLVN 424
Cdd:PLN02843 534 ----YEKGTDTMDVWFDSGSSWAGVL------GSREGLSYPADLYLEGSDQHRGWFQSslLTSVATK--GKAPYKSVLTH 601
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 425 DLILDKKGQKMSKSKGNTVDPFTLFD---------KYGADATR-WYLTVNnppwrptlFSEDDL---------AETQRKF 485
Cdd:PLN02843 602 GFVLDEKGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRlWVASVD--------YTGDVLigpqilkqmSDIYRKL 673
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 486 FGTLlnTYsffaLYANIDKFNfSETFIPYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTIDHLSNWYVR 565
Cdd:PLN02843 674 RGTL--RY----LLGNLHDWK-PDNAVPYEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLD 746
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278124880 566 RNRRRFWKSENNQNKIAAYQT-LYESLKIIAKLLSPFAPFFAEELYQNLNGNTKEEPFESVHLSVFPE 632
Cdd:PLN02843 747 VAKDRLYVGGTTSFTRRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAESVFEAGWPT 814
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
7-710 |
2.78e-80 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 276.30 E-value: 2.78e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 7 CPHCETPLSSHELalGYADVHDPSVYIKFKLNDENASILAwTTTPWTLISNVALAVgsqidyvkiktekHgilylaearl 86
Cdd:PRK13208 177 CPRCETAIAQAEV--EYREREGKLNYIKFPVEDGEEIEIA-TTRPELLPACVAVVV-------------H---------- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 87 sviKEDyEIISHLKGadllnKEYE-PLFSY-IPtdkkgwyVVPGDFVSTEDGTGVVHIApAFGaD--DYEVSKKFDLPFL 162
Cdd:PRK13208 231 ---PDD-ERYKHLVG-----KTAIvPLFGVeVP-------ILADPLVDPDFGTGAVMIC-TFG-DktDVTWWRELNLPTR 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 163 QPVTKGGRFTSEVTDFAGRLVKSLKfttheEKgvdpdVVRNLKERGLIYKAgNDHLHSYPHCWRCDNPLIYYARDSWYIR 242
Cdd:PRK13208 293 IIIDEDGRMTEAAGKLAGLTIEEAR-----KK-----IVEDLKSGGLLGKQ-EPIKHNVKFCERCDTPLEILVTRQWFIK 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 243 TTEISKRMIELNKTINWYPPEVGSgRFGNWLEE-NKDWSLSRDRYWGTPLPLWlndegdmfaigsvaelkegFVERDGKK 321
Cdd:PRK13208 362 VLDLKEELLERGKEINWYPEHMRV-RLENWIEGlNWDWCISRQRYFGTPIPVW-------------------YCKDCGHP 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 322 IL--VRDLP-REEIDLHKPFVDDvtfERNGKIYKRTPELIDVWFDSGSMPFAQYHYPfENQEWFDKNFPADFICEGIDQT 398
Cdd:PRK13208 422 ILpdEEDLPvDPTKDEPPGYKCP---QCGSPGFEGETDVMDTWATSSITPLIVTGWE-RDEDLFEKVFPMDLRPQGHDII 497
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 399 RGW-FYTLhAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWyltvnnppW----RP--- 470
Cdd:PRK13208 498 RTWlFYTI-LRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRY--------WaasaRLgsd 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 471 TLFSEDDLaETQRKFFGTLLNTYSF---FALYANIDKfnfsetfiPYDERPeIDRWIISKLNSVVKEYQQFMDSYDVTKA 547
Cdd:PRK13208 569 TPFDEKQV-KIGRRLLTKLWNASRFvlhFSADPEPDK--------AEVLEP-LDRWILAKLAKVVEKATEALENYDFAKA 638
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 548 ARLIYSFTIDHLSNWYVRRNRRRFWKSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGntkeepfESVHL 627
Cdd:PRK13208 639 LEEIESFFWHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYG-------GSVHR 711
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 628 SVFPE--MKIADKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKIMVAVDAAkRSSLEQMRDVILEEVNVKELIVLTD 705
Cdd:PRK13208 712 ASWPEpdEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVYGPAD-LELLEAAEEDLKAAGNIEELELVEG 790
|
....*
gi 1278124880 706 DANIV 710
Cdd:PRK13208 791 DPELE 795
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
473-655 |
7.82e-80 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 255.94 E-value: 7.82e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 473 FSEDDLAETQRKFFGTLLNTYSFFALYANIDKFNFSETFIPYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIY 552
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 553 SFtIDHLSNWYVRRNRRRFWKSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGNTKEEPfESVHLSVFPE 632
Cdd:cd07961 81 EF-IDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAP-ESVHLLDWPE 158
|
170 180
....*....|....*....|....*
gi 1278124880 633 MKIA--DKALEEKMELAQRVVYLTR 655
Cdd:cd07961 159 VDESliDEELEEAMELVREIVELGR 183
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
7-714 |
1.52e-76 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 267.36 E-value: 1.52e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 7 CPHCETPLSSHELAlgYADVHDPSVYIKFKLNDENASILAWTTTPWTLISNVALAVgsqidyvkiktekHgilylaearl 86
Cdd:PRK05729 178 DPKLQTALSDLEVE--YKEVKGKLWHIRYPLADGSDYLVVATTRPETMLGDTAVAV-------------N---------- 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 87 sviKED--YeiiSHLKGAD----LLNKEyeplfsyIPtdkkgwyVVPGDFVSTEDGTGVVHIAPAFGADDYEVSKKFDLP 160
Cdd:PRK05729 233 ---PEDerY---KHLIGKTvilpLVGRE-------IP-------IIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLP 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 161 FLQPVTKGGRFTSEVTDFAG--RLVkslkfttheekgVDPDVVRNLKERGLIYKAgNDHLHSYPHCWRCDNPLIYYARDS 238
Cdd:PRK05729 293 MINIMDEDGTINENPGEYQGldRFE------------ARKAIVADLEELGLLVKI-EPHTHSVGHSDRSGVVIEPYLSDQ 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 239 WYIRTTEISKRMIEL--NKTINWYPPevgsgRFGN----WLEENKDWSLSRDRYWGTPLPLWLNDEGDMFaigsVAELKE 312
Cdd:PRK05729 360 WFVKMKPLAKPALEAveNGEIKFVPE-----RWEKtyfhWMENIQDWCISRQLWWGHRIPAWYDEDGEVY----VGREEP 430
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 313 gfvERDGKKILVRDlpreeidlhkpfvDDVtferngkiykrtpelIDVWFDSGSMPFAQYHYPfENQEWFDKNFPAD--- 389
Cdd:PRK05729 431 ---EAREKALLTQD-------------EDV---------------LDTWFSSALWPFSTLGWP-EKTEDLKRFYPTSvlv 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 390 -------FicegidqtrgW-----FYTLHAIstmlfDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADAT 457
Cdd:PRK05729 479 tgfdiifF----------WvarmiMMGLHFT-----GQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADAL 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 458 RWYLTVNNPPWRPTLFSEDDLaETQRKFFGTLLNTySFFALyANIDKFNFsETFIPYDERPEIDRWIISKLNSVVKEYQQ 537
Cdd:PRK05729 544 RFTLAALASPGRDIRFDEERV-EGYRNFANKLWNA-SRFVL-MNLEGADV-GELPDPEELSLADRWILSRLNRTVAEVTE 619
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 538 FMDSYDVTKAARLIYSFTIDHLSNWYVrrnrrRFWKSE-NNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGn 616
Cdd:PRK05729 620 ALDKYRFDEAARALYEFIWNEFCDWYL-----ELAKPVlQEAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAP- 693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 617 tkEEPFESVHLSVFPEMKIA-DKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKIMVAVDAAKRSSLEQMRDVILEEV 695
Cdd:PRK05729 694 --LGIEESIMLAPWPEADEAiDEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLA 771
|
730
....*....|....*....
gi 1278124880 696 NVKELIVLTDDANIVTKSA 714
Cdd:PRK05729 772 RLESLEILADDEEAPEGAA 790
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
7-707 |
2.27e-72 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 255.75 E-value: 2.27e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 7 CPHCETPLSSHELAlgYADVHDPSVYIKFKLNDENASILAWTTTPWTLISNVALAVgsqidyvkiktekHgilylaearl 86
Cdd:COG0525 177 DPKLKTALSDLEVE--HEEVKGHLWHIRYPLADGSGYIVVATTRPETMLGDTAVAV-------------H---------- 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 87 sviKED--YeiiSHLKGAD----LLNKEyeplfsyIPtdkkgwyVVPGDFVSTEDGTGVVHIAPAFGADDYEVSKKFDLP 160
Cdd:COG0525 232 ---PEDerY---KHLIGKTvilpLVGRE-------IP-------IIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLP 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 161 FLQPVTKGGRftseVTDFAGRLVkslkfttheekGVDPDVVRN-----LKERGLIYKAgNDHLHSYPHCWRCDNPLIYYA 235
Cdd:COG0525 292 MINILDEDGT----INENAGKYR-----------GLDRFEARKaivadLEELGLLVKV-EPHKHSVGHSDRSGTVIEPYL 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 236 RDSWYIRTTEISKRMIE--LNKTINWYPPevgsgRFGN----WLEENKDWSLSRDRYWGTPLPLWLNDEGDMFaigsVAE 309
Cdd:COG0525 356 SDQWFVKMKPLAKPAIEavEDGEIKFVPE-----RWEKtyfhWMENIRDWCISRQLWWGHRIPAWYCPDGEVY----VAR 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 310 LKEGFVERDGKKILVRDlpreeidlhkpfvDDVtferngkiykrtpelIDVWFDSGSMPFAQYHYPFENQEwFDKNFPAD 389
Cdd:COG0525 427 TEPEACAKAGSVNLTQD-------------EDV---------------LDTWFSSALWPFSTLGWPEKTED-LKYFYPTS 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 390 ----------FicegidqtrgW-----FYTLHAIstmlfDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGA 454
Cdd:COG0525 478 vlvtgfdiifF----------WvarmiMMGLHFT-----GEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGA 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 455 DATRWYLTVNNPPWRPTLFSEdDLAETQRKFFGTLLNTySFFALyANIDKFNFSETfIPYDERPEIDRWIISKLNSVVKE 534
Cdd:COG0525 543 DALRFTLAALASPGRDIKFDE-ERVEGYRNFANKLWNA-SRFVL-MNLEGFDPGLD-PDPEELSLADRWILSRLNKTIAE 618
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 535 YQQFMDSYDVTKAARLIYSFTIDHLSNWYVRRNRRRFWkSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLN 614
Cdd:COG0525 619 VTEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPRLY-GGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLP 697
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 615 GNTKEepfESVHLSVFPEMKIA--DKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKIMVAVDAAKRSSLEQMRDVIL 692
Cdd:COG0525 698 PRKEG---ESIMLAPWPEADEEliDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIK 774
|
730
....*....|....*
gi 1278124880 693 EEVNVKELIVLTDDA 707
Cdd:COG0525 775 RLARLEEITILVDEK 789
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
689-884 |
8.28e-66 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 218.50 E-value: 8.28e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 689 DVILEEVNVKELIVLTDDANIVTKSAKPNFKTLGPKFGKKVNPVANAIREFDKDLIGKLEKGESVFVTLGGESFEVQKSD 768
Cdd:pfam19302 2 DIIKEELNVKEVEFGADESELVEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTLTIDVDGEEIELTSED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 769 VEIISSEITGWSVESDEGVTVALDTLLNDDLIQEGLAREFVNRIQNMRKDAGFEVTDRILISAEAIDDFVDAIKRFKQYI 848
Cdd:pfam19302 82 LLVTRQGKEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEMLEAAIEKFEDYI 161
|
170 180 190
....*....|....*....|....*....|....*.
gi 1278124880 849 TNETLANEITFeiGEAGFSQTWEIGAHSISITIQKV 884
Cdd:pfam19302 162 KKETLAVEIIF--NEEKEYTEVDINGEKLKIAVEKV 195
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
2-775 |
3.48e-62 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 228.34 E-value: 3.48e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 2 KIVPQCPHCETPLSshELALGYADVHDPSVY-IKFKLNDENASILAWTTTPWTLISNVALAVGSQidyvkikTEKHGILY 80
Cdd:PRK14900 186 KLINWCPDCRTALS--DLEVEHEEAHQGELWsFAYPLADGSGEIVVATTRPETMLGDTAVAVHPL-------DPRYMALH 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 81 LAEARLSVIKEDYEIISHlkgADLLnkeyEPLFsyiptdkkgwyvvpgdfvstedGTGVVHIAPAFGADDYEVSKKFDLP 160
Cdd:PRK14900 257 GKKVRHPITGRTFPIVAD---AILV----DPKF----------------------GTGAVKVTPAHDFNDFEVGKRHGLE 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 161 FLQPVTKGGRFTSEVTDFAGRLvkslKFTTHeekgvdPDVVRNLKERGLIYKAgNDHLHSYPHCWRCDNPLIYYARDSWY 240
Cdd:PRK14900 308 MITVIGPDGRMTAEAGPLAGLD----RFEAR------KEVKRLLAEQGLDRGA-KPHVLPLGRCQRSATILEPLLSDQWY 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 241 IRTTEISKRMIE-LNKTINWYPPEVGSGRFGNWLEENKDWSLSRDRYWGTPLPLWLNDEGDMfaigSVAELKEGFVERDG 319
Cdd:PRK14900 377 VRIEPLARPAIEaVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHV----TVARETPEACSTCG 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 320 KKILVRDlpreeidlhkpfvddvtferngkiykrtPELIDVWFDSGSMPFAQYHYPfENQEWFDKNFPADFICEGIDQTR 399
Cdd:PRK14900 453 KAELRQD----------------------------EDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDIIF 503
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 400 GWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPPWRPTLFSEDDLa 479
Cdd:PRK14900 504 FWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERI- 582
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 480 ETQRKFFGTLLNTySFFALyANIDKFNFSEtfIPYDERPEI--DRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTID 557
Cdd:PRK14900 583 EGYRAFANKLWNA-SRFAL-MNLSGYQERG--EDPARLARTpaDRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWH 658
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 558 HLSNWYVRRNRRRFWkSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGNTKEEPF-ESVHLSVFPEMKIA 636
Cdd:PRK14900 659 ELCDWYIELAKEALA-SEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAWaDSVLAAEYPRKGEA 737
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 637 DKALEEKMELAQRVVYLTRAMRAKLNL----KVRQPLQKIMVAVDAAKRSSLEQMrdvilEEVNVKELIVLtDDANIVTK 712
Cdd:PRK14900 738 DEAAEAAFRPVLGIIDAVRNIRGEMGIpwkvKLGAQAPVEIAVADPALRDLLQAG-----ELARVHRVAGV-EGSRLVVA 811
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1278124880 713 S--AKP--NFKTLGPKFGKKVnPVANAI------REFDKDlIGKLEKG-ESVFVTLGGESFeVQKSDVEIISSE 775
Cdd:PRK14900 812 AatAPApqSAVGVGPGFEVRV-PLAGVIdlaaetARVDKE-IGKVDQDlAVLERKLQNPSF-VQNAPPAVVEKD 882
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
130-709 |
2.40e-53 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 201.39 E-value: 2.40e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 130 FVSTEDGTGVVHIAPAFGADDYEVSKKFDLPFLQPVTKGGRFTSEVTDFAGRLvkslKFTTHEEkgvdpdVVRNLKERGL 209
Cdd:PTZ00419 306 LVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMH----RFDCRRK------IEEELKEMGL 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 210 iYKAGNDHLHSYPHCWRCDNPLIYYARDSWYIRTTEISKRMIEL--NKTINWYPPEVGSGRFgNWLEENKDWSLSRDRYW 287
Cdd:PTZ00419 376 -LRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKIIPSSHENVWY-HWLENIQDWCISRQLWW 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 288 GTPLPLWLndegdmfaIGSVAELKEGFVERdgKKILVRDLprEE-----IDLHKPFVDDVTFERNgkiykrtPELIDVWF 362
Cdd:PTZ00419 454 GHRIPAYR--------VISKGPETDPSDEE--PWVVARSE--EEalekaKKKFGLSEEDFELEQD-------EDVLDTWF 514
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 363 DSGSMPFAQYHYPFENQEwFDKNFPADFICEGIDQTRGWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNT 442
Cdd:PTZ00419 515 SSGLFPFSTLGWPDQTDD-LQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNV 593
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 443 VDPF---------TLFDKY----------------------------GADATRWYLtvnnppwrptlfseddLAETQ--- 482
Cdd:PTZ00419 594 IDPLeviegislqDLNQKLyegnlpekeikraielqkkefpngipecGTDALRFGL----------------LAYTQqgr 657
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 483 ------------RKFFGTLLNTYSFFALYANIDKFNFSETFIPYDERPE---IDRWIISKLNSVVKEYQQFMDSYDVTKA 547
Cdd:PTZ00419 658 ninldinrvvgyRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNVESlpwEDKWILHRLNVAIKEVTEGFKEYDFSEA 737
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 548 ARLIYSFTIDHLSNWYVRRNRRRFWKSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGNtkEEPFESVHL 627
Cdd:PTZ00419 738 TQATYNFWLYELCDVYLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNY--LRKSESISI 815
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 628 SVFPE--MKIADKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKIMVAVDAAKRSSLEQMRDVILEEVNVKELIVLTD 705
Cdd:PTZ00419 816 AKYPQpnPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELIELIESAENLISTLAKIGSVSVIPP 895
|
....
gi 1278124880 706 DANI 709
Cdd:PTZ00419 896 IEEE 899
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
203-467 |
5.95e-50 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 178.77 E-value: 5.95e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 203 NLKERGLIYKAgndhlhsyphcwrcdnPLIYYARDSWYIRTTEISKRMIELNKTINWYPPEVGSgRFGNWLEENKDWSLS 282
Cdd:cd00668 122 RLYEKGLIYRG----------------THPVRITEQWFFDMPKFKEKLLKALRRGKIVPEHVKN-RMEAWLESLLDWAIS 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 283 RDRYWGTPLPLWLndegdmfaigsvaelkegfverdgkkilvrdlpreeidlhkpfvddvtferngkiykrtpelIDVWF 362
Cdd:cd00668 185 RQRYWGTPLPEDV--------------------------------------------------------------FDVWF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 363 DSGSMPFAQYHYPFENqEWFDKNFPADFICEGIDQTRGWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNT 442
Cdd:cd00668 203 DSGIGPLGSLGYPEEK-EWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNV 281
|
250 260
....*....|....*....|....*
gi 1278124880 443 VDPFTLFDKYGADATRWYLTVNNPP 467
Cdd:cd00668 282 IDPSDVVEKYGADALRYYLTSLAPY 306
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
224-473 |
3.07e-42 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 158.95 E-value: 3.07e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 224 CWRCDNPLIYYARDSWYIRTTEISKRMIEL--NKTINWYPpEVGSGRFGNWLEENKDWSLSRDRYWGTPLPLWlndegdm 301
Cdd:cd00817 156 CSRSGDVIEPLLKPQWFVKVKDLAKKALEAvkEGDIKFVP-ERMEKRYENWLENIRDWCISRQLWWGHRIPAW------- 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 302 faigsvaelkegFVERDGKKILVRdlprEEIDLHKPFVDDVTFERNGKIYKRTPELIDVWFDSGSMPFAQYHYPfENQEW 381
Cdd:cd00817 228 ------------YCKDGGHWVVAR----EEDEAIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWP-EETKD 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 382 FDKNFPADFICEGIDQTRGW-FYTLhAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWY 460
Cdd:cd00817 291 LKKFYPTSLLVTGHDIIFFWvARMI-MRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFT 369
|
250
....*....|...
gi 1278124880 461 LTVNNPPWRPTLF 473
Cdd:cd00817 370 LASAATQGRDINL 382
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
521-672 |
2.22e-37 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 136.76 E-value: 2.22e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 521 DRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTIDHLSNWYVRRNRRRFWKSENNQNkiaAYQTLYESLKIIAKLLSP 600
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR---AQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1278124880 601 FAPFFAEELYQNlngntkeepfESVHLSVFPEMKIA-DKALEEKMELAQRVVYLTRAMRAKLNLKVRQPLQKI 672
Cdd:pfam08264 78 FMPFITEELWQK----------ESIHLAPWPEDAELeEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVV 140
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
8-716 |
4.41e-37 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 150.48 E-value: 4.41e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 8 PHCETPLSshELALGYADVHDPSVYIKFKLNDENASILAWTTT-PWTLISNVALAVGSQIDYVKIKTEKHGILYLAEARl 86
Cdd:PLN02943 231 PNLQTAVS--DLEVEYSEEPGTLYYIKYRVAGGSEDFLTIATTrPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMTYGR- 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 87 svikedyeiishlkgadllnkeyeplfsYIPtdkkgwyVVPGDFVSTEDGTGVVHIAPAFGADDYEVSKKFDLPFLQPVT 166
Cdd:PLN02943 308 ----------------------------HVP-------IIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMN 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 167 KGGrftsEVTDFAGrlvkSLKFTTHEEKGVDpdvvrnLKERGLIYKAgNDHLHSYPHCWRCDNPLIYYARDSWYIRTTEI 246
Cdd:PLN02943 353 KDG----TLNEVAG----LYWFEAREKLWSD------LEETGLAVKK-EPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPL 417
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 247 S-KRMIELNKTINWYPPEVGSGRFGNWLEENKDWSLSRDRYWGTPLPLWlndegdmFAIGSVAElKEGFVERDGKKILVR 325
Cdd:PLN02943 418 AeKALKAVENGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIPVW-------YIVGKDCE-EDYIVARSAEEALEK 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 326 DLPReeidlhkpfvddvtFERNGKIYKRtPELIDVWFDSGSMPFAQYHYPFENQEWFDKNFPADFICEGIDQTRGWFYTL 405
Cdd:PLN02943 490 AREK--------------YGKDVEIYQD-PDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETGHDILFFWVARM 554
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 406 HAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPPWRPTLFSE---DDLAETQ 482
Cdd:PLN02943 555 VMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTErltSNKAFTN 634
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 483 R-----KFFGTLLNTYSFFALYANI--DKFNFSETFIpydERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFT 555
Cdd:PLN02943 635 KlwnagKFVLQNLPSQSDTSAWEHIlaCKFDKEESLL---SLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFF 711
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 556 IDHLSNWYVRRNRRRFWKSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLngntkeePFESVHLSVFPEMKI 635
Cdd:PLN02943 712 WSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQAL-------PYRKEALIVSPWPQT 784
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 636 ADKALEEKMELAQRVVYLTRAMR-AKLNLKVrQPLQKIMVAVDAAkrsslEQMRDVILEEVNVKELIVLTDDANIVTKSA 714
Cdd:PLN02943 785 SLPKDLKSIKRFENLQSLTRAIRnARAEYSV-EPAKRISASIVAS-----AEVIEYISKEKEVLALLSRLDLQNVHFTDS 858
|
..
gi 1278124880 715 KP 716
Cdd:PLN02943 859 PP 860
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
136-661 |
3.33e-31 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 131.95 E-value: 3.33e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 136 GTGVVHIAPAFGADDYEVSKKFDLPFLQPVTKGGRFTSEV-TDFAGrlvkSLKFTTHEEkgvdpdVVRNLKERGLIYKAG 214
Cdd:PLN02381 378 GTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGgSEFAG----MPRFAAREA------VIEALQKKGLYRGAK 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 215 NDHLHsYPHCWRCDN---PLIyyaRDSWYIRTTEISKRMIEL-----NKTINWYPPEVgSGRFGNWLEENKDWSLSRDRY 286
Cdd:PLN02381 448 NNEMR-LGLCSRTNDvvePMI---KPQWFVNCSSMAKQALDAaidgeNKKLEFIPKQY-LAEWKRWLENIRDWCISRQLW 522
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 287 WGTPLPLW---LNDEgdmfaigsvaELKEgFVERDGKKILVRDLPREEIDLHKPFvddvtferNGKIYK--RTPELIDVW 361
Cdd:PLN02381 523 WGHRIPAWyvtLEDD----------QLKE-LGSYNDHWVVARNESDALLEASQKF--------PGKKFElsQDPDVLDTW 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 362 FDSGSMPFAQYHYPFENQEwFDKNFPADFICEGIDQTRGWFYTLHAISTMLFDKVAYKNVLVNDLILDKKGQKMSKSKGN 441
Cdd:PLN02381 584 FSSGLFPLSVLGWPDDTDD-LKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGN 662
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 442 TVDPFTLFDKYGADATRWYLTVNN--PpwrptlfSEDDLA-ETQRKFF-------GTLLNTYSFFALYANIDKFN----- 506
Cdd:PLN02381 663 VIDPLEVINGISLEGLHKRLEEGNldP-------KELVVAkEGQKKDFpngiaecGTDALRFALVSYTAQSDKINldilr 735
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 507 ---------------------FSETFIP-----YDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTIDHLS 560
Cdd:PLN02381 736 vvgyrqwcnklwnavrfamskLGDDYTPpatlsVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFC 815
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 561 NWYVRRNRRRFW--KSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNGNTKEEPFESVHLSVFPEMKIA-- 636
Cdd:PLN02381 816 DVFIEAIKPYFAgdNPEFASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHTRKDSIMISEYPSAVEAwt 895
|
570 580
....*....|....*....|....*
gi 1278124880 637 DKALEEKMELAQRVVYLTRAMRAKL 661
Cdd:PLN02381 896 NEKVEYEMDLVLSTVKCLRSLRAEV 920
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
7-750 |
3.56e-29 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 125.37 E-value: 3.56e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 7 CPHCETPLSSHELaLGYADVhDPSVY--IKFKlNDENASILAWTTTPWTLISNVALAVGSQIDYVKIKT--EKHGILYLA 82
Cdd:PRK12300 136 CPNDNNPVGDHDL-LDGEEP-EIVEYtlIKFE-ESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVdgEKWIVSKEA 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 83 EARLSVIKEDYEIISHLKGADLLNKEYE-PLF-SYIPtdkkgwyVVPGDFVSTEDGTGVVHIAPAFGADDY--------- 151
Cdd:PRK12300 213 AEKLSFQDRDVEIIEEIKGSELIGKKVKnPVTgKEVP-------ILPADFVDPDNGTGVVMSVPAHAPYDYvalrdlkkn 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 152 ------------------------EVSKKFDL-----PFLQPVTK--------GGRFTSEVTDFAGRLVKSLKfttheEK 194
Cdd:PRK12300 286 kelldviepiplievegygefpakEVVEKLGIksqedPELEEATKevyraefhKGVLKENTGEYAGKPVREAR-----EK 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 195 gvdpdVVRNLKERGL---IYKAGNDHLHSyphcwRCDNPLIY-YARDSWYIRT-----TEISKRMIElnkTINWYPPEVG 265
Cdd:PRK12300 361 -----ITKDLIEKGIadiMYEFSNRPVYC-----RCGTECVVkVVKDQWFIDYsdpewKELAHKALD---NMEIIPEEYR 427
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 266 SgRFGN---WLeenKDWSLSRDRYWGTPLPlWlnDEGDMF----------AIGSVAelkegfverdgKKILVRDLPREEI 332
Cdd:PRK12300 428 K-EFENtidWL---KDRACARRRGLGTRLP-W--DEEWIIeslsdstiymAYYTIA-----------HKIREYGIKPEQL 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 333 D--------LHKPFVDDVtfERNGKIYKrtpELIDvwfdsgsmpfaqyhypfENQEWFDKNFPADFICEGID--QTRGWF 402
Cdd:PRK12300 490 TpeffdyvfLGKGDPEEV--SKKTGIPK---EILE-----------------EMREEFLYWYPVDWRHSGKDliPNHLTF 547
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 403 YTLH--AIstmlFDKVAY-KNVLVNDLILdKKGQKMSKSKGNTvdpFTLFD---KYGADATRWYLTVNNPPWRPTLFSED 476
Cdd:PRK12300 548 FIFNhvAI----FPEEKWpRGIVVNGFVL-LEGKKMSKSKGNV---IPLRKaieEYGADVVRLYLTSSAELLQDADWREK 619
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 477 DLAETQRkffgtllntysffalyaNIDKF-NFSETFIPYDERPE---IDRWIISKLNSVVKEYQQFMDSYDVTKAARLIY 552
Cdd:PRK12300 620 EVESVRR-----------------QLERFyELAKELIEIGGEEElrfIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAF 682
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 553 sFTIDHLSNWYVRRnrrrfwkSENNQNKIaayqtLYESLKIIAKLLSPFAPFFAEELYQNLNGNTkeepFesVHLSVFPE 632
Cdd:PRK12300 683 -YELLNDLRWYLRR-------VGEANNKV-----LREVLEIWIRLLAPFTPHLAEELWHKLGGEG----F--VSLEKWPE 743
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 633 MKIA--DKALEEKMELAQRVVYLTRAMRAKLNLKVRqplqKIMVAV-DAAKRSSLEqmrdVILEEVNVKELIvltddANI 709
Cdd:PRK12300 744 PDESkiDEEAELAEEYVKRLIEDIREILKVAKIKPK----KVYIYVaPDWKYEVLE----IAAENGDVKEAI-----KEL 810
|
810 820 830 840
....*....|....*....|....*....|....*....|.
gi 1278124880 710 VtksAKPNFKTLGPKFGKKVNPVANAIREFDKDLIGKLEKG 750
Cdd:PRK12300 811 M---KDEELRKHGKEVAKLAQKIVKEVLKLDKEVRKLILKN 848
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
478-650 |
2.11e-26 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 106.84 E-value: 2.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 478 LAETQRKFFGTLlntysFFALyANIDKFNFSETFIPYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTID 557
Cdd:cd07960 9 VAEAYRKIRNTF-----RFLL-GNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 558 HLSNWY--VRRNR----------RRfwksennqnkiaAYQT-LYESLKIIAKLLSPFAPFFAEELYQNLNGNTKEepfES 624
Cdd:cd07960 83 DLSAFYldIIKDRlycdakdsleRR------------SAQTvLYHILDALLKLLAPILPFTAEEVWEHLPGEKKE---ES 147
|
170 180
....*....|....*....|....*...
gi 1278124880 625 VHLSVFPEMKIA--DKALEEKMELAQRV 650
Cdd:cd07960 148 VFLEDWPELPEEwkDEELEEKWEKLLAL 175
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
473-613 |
1.09e-25 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 103.02 E-value: 1.09e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 473 FSEDDLaETQRKFFGTLLNTYSFFALYANidkfNFSETFIPYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIY 552
Cdd:cd07962 1 FDEKRV-EGGRNFCNKLWNAARFVLMNLE----DDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALY 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1278124880 553 SFTIDHLSNWYVRRNRRRFWkSENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNL 613
Cdd:cd07962 76 EFFWNDFCDWYLELVKPRLY-GEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
222-648 |
1.32e-24 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 109.05 E-value: 1.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 222 PHCWRCDNPLIYYARDSWYIRTTEISKRMIElnktinWY--PPEVGSGRFG---NWLEEN-KDWSLSRDRYWGTPLPlwl 295
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLLE------WIeeNPDIQPEVRNevlSWLKEGlQDLSISRDFDWGIPVP--- 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 296 ndeGDmfaigsvaelkEGFVerdgkkilvrdlpreeidlhkpfvddvtferngkIYkrtpelidVWFD------SGSMPF 369
Cdd:COG0143 240 ---GD-----------PGKV----------------------------------FY--------VWFDaligyiSATKGY 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 370 AQYHYPFENqewFDKNFPAD------FIceGIDQTRgwFytlHAIS--TMLF--DKVAYKNVLVNDLILdKKGQKMSKSK 439
Cdd:COG0143 264 ADDRGLPED---FEKYWPAPdtelvhFI--GKDIIR--F---HAIIwpAMLMaaGLPLPKKVFAHGFLT-VEGEKMSKSR 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 440 GNTVDPFTLFDKYGADATRWYLTVNNPPWRPTLFSED--------DLAETqrkfFGTLLN-TYSFfalyanIDKfNFSET 510
Cdd:COG0143 333 GNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEdfvarvnsDLAND----LGNLASrTLSM------IHK-YFDGK 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 511 FIPYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFtIDhLSNWYVrrNRRRFWKSENNQNKIAAYQTLY-- 588
Cdd:COG0143 402 VPEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMAL-AR-AANKYI--DETAPWKLAKDEDPERLATVLYtl 477
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278124880 589 -ESLKIIAKLLSPFAPFFAEELYQNLNGNTKEEPFESVHLSVFPEMKIADKA-----LEEKMELAQ 648
Cdd:COG0143 478 lEALRILAILLKPFLPETAEKILEQLGLEGDELTWEDAGWPLPAGHKIGKPEplfprIEDEQIEAL 543
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
128-710 |
3.25e-23 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 105.90 E-value: 3.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 128 GDFVSTEDGTGVVHIAPAFGADDYEVSKKFDLPFLQPVTKGGRFTSEVTDFA----GRLVKSLKFTtheekgvdpdvvrn 203
Cdd:COG0495 325 ADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDDPDILEEAytgdGVLINSGEFD-------------- 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 204 lkerGLIYKAGNDhlhsyphcwrcdnpliyyardswyirttEISKRMIELN---KTINWyppevgsgRFgnwleenKDWS 280
Cdd:COG0495 391 ----GLDSEEAKE----------------------------AIIEWLEEKGlgkRKVNY--------RL-------RDWL 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 281 LSRDRYWGTPLPLWLNDEGdmfaiGSVAELKEgfverdgkkilvrDLP---REEIDL----------HKPFVDdVTFERN 347
Cdd:COG0495 424 ISRQRYWGEPIPIIHCEDC-----GVVPVPED-------------QLPvelPEDVDFdptggsplarAPEWVN-VTCPKC 484
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 348 GKIYKRTPELIDVWFDSgSMPFAQYHYPFENQEWFDKN-----FPADFICEGIDqtrgwfytlHAISTML----FDKVAY 418
Cdd:COG0495 485 GGPARRETDTMDTFVDS-SWYYLRYTDPHNDEAPFDPEaanywLPVDQYIGGIE---------HAILHLLyarfFTKVLR 554
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 419 -----------KNVL----VNDLILD----KKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPPwrptlfsEDDL- 478
Cdd:COG0495 555 dlglvsfdepfKRLLtqgmVLEVGKDgvviGGIEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPP-------ERDLe 627
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 479 -----AETQRKFfgtlLN-TYSFFALYANIDKFNFSEtfiPYDERPEIDRwiisKLNSVVKEYQQFMDSYDVTKA-ARL- 550
Cdd:COG0495 628 wsdsgVEGAYRF----LNrVWRLVVDEAEALKLDVAD---LSEADKELRR----ALHKTIKKVTEDIERLRFNTAiAALm 696
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 551 -----IYSFTIDHLSNWYVRRnrrrfwksennqnkiaayqtlyESLKIIAKLLSPFAPFFAEELYQNLnGNTkeepfESV 625
Cdd:COG0495 697 elvnaLYKAKDSGEADRAVLR----------------------EALETLVLLLAPFAPHIAEELWERL-GHE-----GSV 748
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 626 HLSVFPEmkiADKAL--EEKMELAQRVvyltramraklNLKVRqplQKIMVAVDAAKrsslEQMRDVILEEVNVKELIvl 703
Cdd:COG0495 749 ADAPWPE---ADEAAlvEDEVTIVVQV-----------NGKVR---GKIEVPADASK----EELEAAALADEKVQKFL-- 805
|
....*..
gi 1278124880 704 tDDANIV 710
Cdd:COG0495 806 -EGKTIR 811
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
360-624 |
1.76e-20 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 96.79 E-value: 1.76e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 360 VWFDS--------GsmpfaqyhYPFENQEWFDKNFPADFICEGIDQTRgwFytlHAI--STMLfdKVA----YKNVLVND 425
Cdd:PRK12267 227 VWIDAllnyitalG--------YGSDDDELFKKFWPADVHLVGKDILR--F---HAIywPIML--MALglplPKKVFAHG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 426 LILdKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPPWRPTLFSEDDLAEtqRKFF------GTLLNTysffaLY 499
Cdd:PRK12267 292 WWL-MKDGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSDGDFSPEALVE--RINSdlandlGNLLNR-----TV 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 500 ANIDKFNFSEtfIPY-DERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFtidhlsnwyVRRNRRRF-----W- 572
Cdd:PRK12267 364 AMINKYFDGE--IPApGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKL---------ISRANKYIdetapWv 432
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1278124880 573 --KSENNQNKIAA--YqTLYESLKIIAKLLSPFAPFFAEELYQNLNGNTKEEPFES 624
Cdd:PRK12267 433 laKDEGKKERLATvmY-HLAESLRKVAVLLSPFMPETSKKIFEQLGLEEELTSWES 487
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
360-652 |
1.35e-19 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 93.41 E-value: 1.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 360 VWFD--SGSMPFAQYHY-PFENQEWFDKNFPAD--FIceGIDQTRgwfytLHAIS--TML-------FDKVayknvLVND 425
Cdd:PRK11893 224 VWFDalTNYLTALGYPDdEELLAELFNKYWPADvhLI--GKDILR-----FHAVYwpAFLmaaglplPKRV-----FAHG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 426 LILdKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPPWRPTLFSED--------DLAETqrkfFGTLLN-TYSFf 496
Cdd:PRK11893 292 FLT-LDGEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREafinrinaDLAND----LGNLAQrTLSM- 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 497 alyanIDKfNFSETFIPYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTIDhlSNWYVrrNRRRFWKSEN 576
Cdd:PRK11893 366 -----IAK-NFDGKVPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVRA--ANKYI--DEQAPWSLAK 435
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1278124880 577 NQNKIAAY--QTLYESLKIIAKLLSPFAPFFAEELYQNLNgntkEEPFESVHLSVFPEMKI-ADKALEEKMELAQRVVY 652
Cdd:PRK11893 436 TDPERLATvlYTLLEVLRGIAVLLQPVMPELAAKILDQLG----VEEDENRDFAALSWGRLaPGTTLPKPEPIFPRLEE 510
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
222-614 |
2.15e-19 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 92.83 E-value: 2.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 222 PHCWRCDNPLIYYARDSWYIRTTEISKRMIELNKTinwyPPEVGSG------RFGNWLEEN-KDWSLSRD-RYWGTPLPl 293
Cdd:TIGR00398 167 PRCKICGAKPELRDSEHYFFRLSAFEKELEEWIRK----NPESGSPasnvknKAQNWLKGGlKDLAITRDlVYWGIPVP- 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 294 wlndegdmfaigsvaelkegfverdgkkilvrdlpreeidlhkpfvddvtFERNGKIYkrtpelidVWFDS--GSMPFAQ 371
Cdd:TIGR00398 242 --------------------------------------------------NDPNKVVY--------VWFDAliGYISSLG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 372 YHYPFEN--QEWFDKNFPAD---FIceGIDQTRgwFYTLH-AISTMLFDKVAYKNVLVNDLILDKkGQKMSKSKGNTVDP 445
Cdd:TIGR00398 264 ILSGDTEdwKKWWNNDEDAElihFI--GKDIVR--FHTIYwPAMLMGLGLPLPTQVFSHGYLTVE-GGKMSKSLGNVVDP 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 446 FTLFDKYGADATRWYLTVNNPPWRPTLFSEDDLAETQR----KFFGTLLN-TYSFfalyanidKFNFSETFIP-YDERPE 519
Cdd:TIGR00398 339 SDLLARFGADILRYYLLKERPLGKDGDFSWEDFVERVNadlaNKLGNLLNrTLGF--------IKKYFNGVLPsEDITDE 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 520 IDRWIISKLNSVVKEYQQFMDSYDVTKAARLIysFTIDHLSNWYVRRNRRrfWKSENNQNKIAAYQ-TLYESLKIIAKLL 598
Cdd:TIGR00398 411 EDKKLLKLINEALEQIDEAIESFEFRKALREI--MKLADRGNKYIDENKP--WELFKQSPRLKELLaVCSMLIRVLSILL 486
|
410
....*....|....*.
gi 1278124880 599 SPFAPFFAEELYQNLN 614
Cdd:TIGR00398 487 YPIMPKLSEKILKFLN 502
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
483-602 |
1.78e-16 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 76.39 E-value: 1.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 483 RKFFGTLLNTYSFFALYANIdkfnFSETFIPyDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTidHLSNW 562
Cdd:cd07375 8 RAFLNRLYRLLSFFRKALGG----TQPKWDN-ELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFT--NELNW 80
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1278124880 563 YVRRNRRRFWKSENNQnkiAAYQTLYESLKIIAKLLSPFA 602
Cdd:cd07375 81 YLDELKPALQTEELRE---AVLAVLRAALVVLTKLLAPFT 117
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
199-467 |
4.27e-15 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 77.19 E-value: 4.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 199 DVVRNLKERGLIYKAGndhlHSYPHCWRCDNPL-IYYARDSWYIRTTEISKRMIE-LNKTINWYPPEVGSGRFGNWLEEN 276
Cdd:cd00814 103 EFFKKLYENGYIYEGE----YEGLYCVSCERFLpEWREEEHYFFRLSKFQDRLLEwLEKNPDFIWPENARNEVLSWLKEG 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 277 -KDWSLSRDR-YWGTPLPlwlndegdmfaigsvaelkegfverdgkkilvrdlpreeidlhkpfvddvtFERNGKIYkrt 354
Cdd:cd00814 179 lKDLSITRDLfDWGIPVP---------------------------------------------------LDPGKVIY--- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 355 pelidVWFDS--GSMPFAQYH-YPFENQEWFDKNFPAD--FIceGIDQTRgwFytlHAI--STMLF--DKVAYKNVLVND 425
Cdd:cd00814 205 -----VWFDAliGYISATGYYnEEWGNSWWWKDGWPELvhFI--GKDIIR--F---HAIywPAMLLgaGLPLPTRIVAHG 272
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1278124880 426 LILDKkGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPP 467
Cdd:cd00814 273 YLTVE-GKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPE 313
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
204-468 |
1.29e-14 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 75.75 E-value: 1.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 204 LKERGLIYKAGndhlhsYPHCWRCDnpliyyaRDSWYIRT--TEISKRMIELNKTINWYPPEVGSGrFGNWLEenkdwsL 281
Cdd:cd00812 110 LYEKGLAYKKE------APVNWCKL-------LDQWFLKYseTEWKEKLLKDLEKLDGWPEEVRAM-QENWIG------C 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 282 SRDRYWGTPLPlwlndegdmfaigsvaelkegfverdgkkilvrdlpreeidlhkpfvddVTFerngkiykrtpeLIDVW 361
Cdd:cd00812 170 SRQRYWGTPIP-------------------------------------------------WTD------------TMESL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 362 FDSgSMPFAQY---HYPF--------ENQEWFDKNFPADFICEGIDqtrgwfytlHAI---------STMLFDKVAY--- 418
Cdd:cd00812 189 SDS-TWYYARYtdaHNLEqpyegdleFDREEFEYWYPVDIYIGGKE---------HAPnhllysrfnHKALFDEGLVtde 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1278124880 419 --KNVLVNDLILdKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPPW 468
Cdd:cd00812 259 ppKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPD 309
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
515-613 |
7.89e-14 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 68.77 E-value: 7.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 515 DERPE---IDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYsFTIDHLSNWYVRRnrrrfwkSENNQNKiaayQTLYESL 591
Cdd:cd07959 28 GELEEltfIDRWLLSRLNRLIKETTEAYENMQFREALKEGL-YELQNDLDWYRER-------GGAGMNK----DLLRRFI 95
|
90 100
....*....|....*....|..
gi 1278124880 592 KIIAKLLSPFAPFFAEELYQNL 613
Cdd:cd07959 96 EVWTRLLAPFAPHLAEEIWHEL 117
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
222-481 |
4.09e-12 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 68.86 E-value: 4.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 222 PHCWRCDNPLIYYARDSWYIRTTEISKRMIELNKTINWYPPEVGSGRFGNWLEEN-KDWSLSRDRYWGTPLPlwlndegd 300
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPEWPENVKNMVLEWLKEGlKDRAISRDLDWGIPVP-------- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 301 mfaigsvaelkegfvERDGKKIlvrdlpreeidlhkpfvddvtferngkiYkrtpelidVWFDS--GSMPFAQYhyPFEN 378
Cdd:pfam09334 239 ---------------GAEGKVF----------------------------Y--------VWLDApiGYISATKE--LSGN 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 379 QEWFDKNFPADFICE-----GIDQTRgwFYT------LHAISTMLFDKVAYKNVLVNDlildkkGQKMSKSKGNTVDPFT 447
Cdd:pfam09334 266 EEKWKEWWPNDPDTElvhfiGKDIIY--FHTifwpamLLGAGYRLPTTVFAHGYLTYE------GGKMSKSRGNVVWPSE 337
|
250 260 270
....*....|....*....|....*....|....
gi 1278124880 448 LFDKYGADATRWYLTVNNPPWRPTLFSEDDLAET 481
Cdd:pfam09334 338 ALDRFPPDALRYYLARNRPETKDTDFSWEDFVER 371
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
128-680 |
2.62e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 64.46 E-value: 2.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 128 GDFVSTEDGTGVVHIAPAFGADDYEVSKKFDLPFLQPVTKGgrftsevtdfagrlvkslkftthEEKGVDPDVVrnLKER 207
Cdd:PLN02563 407 ADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPA-----------------------DGNEDDAEKA--YTGE 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 208 GLIYKAGNDHLhsyphcwrcdnpliyyardswyirtteiskrmielnkTINWYPPEVGSGRFGNWLEEN----------- 276
Cdd:PLN02563 462 GVIVNSSSSGL-------------------------------------DINGLSSKEAAKKVIEWLEETgngkkkvnykl 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 277 KDWSLSRDRYWGTPLPLWLNDEGDmfaigsvaelkegfverDGKKILVRDLPRE--EIDLHKP----------FVDDV-- 342
Cdd:PLN02563 505 RDWLFARQRYWGEPIPVVFLEDSG-----------------EPVPVPESDLPLTlpELDDFTPtgtgepplakAVSWVnt 567
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 343 TFERNGKIYKRTPELIDVWfdSGSM-PFAQYHYPFENQEWFDKN-----FPADFICEGIDQ-------TRGW---FYTLH 406
Cdd:PLN02563 568 VDPSSGKPARRETNTMPQW--AGSCwYYLRFMDPKNSNALVDKEkekywMPVDLYVGGAEHavlhllyARFWhkvLYDIG 645
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 407 AIST-----------MLFDKVAY----------------------KNVLVNDLILDKKGQ-----------------KMS 436
Cdd:PLN02563 646 VVSTkepfqclvnqgMILGEVEYtafkdsdgeyvsadtadrlgelQQEKIPEEKVIKSGDsfvlkddpsirliarahKMS 725
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 437 KSKGNTVDPFTLFDKYGADATRWYLTVNNP-----PWRPTLFS--EDDLAETQRKFFGTLLNTYSffalyanidkfnFSE 509
Cdd:PLN02563 726 KSRGNVVNPDDVVSEYGADSLRLYEMFMGPlrdskTWSTSGVEgvHRFLGRTWRLVVGAPLPDGS------------FRD 793
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 510 TFIPYDERPEIDRwiISKLNSVVKEYQQFMDSYDVTKAARLIYSFtIDHLSNWyvrrnrrrfwkseNNQNKiaayqtlyE 589
Cdd:PLN02563 794 GTVVTDEEPSLEQ--LRLLHKCIAKVTEEIESTRFNTAISAMMEF-TNAAYKW-------------DKVPR--------E 849
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 590 SLKIIAKLLSPFAPFFAEELYQNLnGNTKEEPFESvhlsvFPEmkiADKALeekmelaqrVVYLTRAMRAKLNLKVRqpl 669
Cdd:PLN02563 850 AIEPFVLLLSPYAPHLAEELWFRL-GHSNSLAYEP-----WPE---ANPSY---------LVDDTVVLPVQINGKTR--- 908
|
650
....*....|.
gi 1278124880 670 QKIMVAVDAAK 680
Cdd:PLN02563 909 GTIEVEEGCSE 919
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
506-613 |
9.90e-08 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 51.34 E-value: 9.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 506 NFSETFIPYDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIysFTIDHLSNWYVrrNRRRFWKSENNQNKIAAYQ 585
Cdd:cd07957 23 YFGGVVPEFGGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEI--MELARAANKYI--DETAPWKLAKEEDPERLAT 98
|
90 100 110
....*....|....*....|....*....|.
gi 1278124880 586 TLY---ESLKIIAKLLSPFAPFFAEELYQNL 613
Cdd:cd07957 99 VLYvllELLRILAILLSPFMPETAEKILDQL 129
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
419-648 |
9.18e-07 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 52.86 E-value: 9.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 419 KNVLVNDLiLDKKGQKMSKSKGNTVdpftlfdkYGADAT---------RWYLTVNNPPWRPTLFSEDDLaetQRKFFGTL 489
Cdd:PLN02610 334 KTISVTEY-LNYEGGKFSKSKGVGV--------FGNDAKdtnipvevwRYYLLTNRPEVSDTLFTWADL---QAKLNSEL 401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 490 LNTY--------SFFALYANidkfNFSETFIP---YDERPEIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSftIDH 558
Cdd:PLN02610 402 LNNLgnfinrvlSFIAKPPG----AGYGSVIPdapGAESHPLTKKLAEKVGKLVEQYVEAMEKVKLKQGLKTAMS--ISS 475
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 559 LSNWYVRRNRrrFWK--SENNQNKIAAYQTLYESLKIIAKLLSPFAPFFAEELYQNLNgntkeEPFESVHLSvfpemkia 636
Cdd:PLN02610 476 EGNAYLQESQ--FWKlyKEDKPSCAIVVKTSVGLVYLLACLLEPFMPSFSKEVLKQLN-----LPPESLSLS-------- 540
|
250
....*....|..
gi 1278124880 637 dkalEEKMELAQ 648
Cdd:PLN02610 541 ----DEKGEVAR 548
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
432-614 |
2.85e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 50.92 E-value: 2.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 432 GQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPP-WRPTLFSEDDLaetQRKFFGTLLNTYSFFAlyanidkfNFSET 510
Cdd:PRK00133 327 GAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPEtIDDLDFNWEDF---QQRVNSELVGKVVNFA--------SRTAG 395
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 511 FIP--YDERP---EIDRWIISKLNSVVKEYQQFMDSYDVTKAARLIYSFTIdhLSNWYVRRNRRrfWKSeNNQNKIAAYQ 585
Cdd:PRK00133 396 FINkrFDGKLpdaLADPELLEEFEAAAEKIAEAYEAREFRKALREIMALAD--FANKYVDDNEP--WKL-AKQDGERLQA 470
|
170 180 190
....*....|....*....|....*....|..
gi 1278124880 586 TLYESL---KIIAKLLSPFAPFFAEELYQNLN 614
Cdd:PRK00133 471 VCSVGLnlfRALAIYLKPVLPELAERAEAFLN 502
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
400-628 |
4.73e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 47.02 E-value: 4.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 400 GWFYTLHAIST--MLFDKVAYKNVLVNDLI-----------LDKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNP 466
Cdd:PLN02224 319 GWPASLHLIGKdiLRFHAVYWPAMLMSAGLelpkmvfghgfLTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYFFLREVE 398
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 467 PWRPTLFSEDDLAETQRKFF----GTLLNTySFFALYANIDKFNFSETFIPYDERPEIDrwiisKLNSVVKEYQQFMDSY 542
Cdd:PLN02224 399 FGNDGDYSEDRFIKIVNAHLantiGNLLNR-TLGLLKKNCESTLVEDSTVAAEGVPLKD-----TVEKLVEKAQTNYENL 472
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278124880 543 DVTKAARLIysFTIDHLSNWYVRRNRRRFWKSENNQNKIAAYQTL---YESLKIIAKLLSPFAPFFAEELYQNLnGNTkE 619
Cdd:PLN02224 473 SLSSACEAV--LEIGNAGNTYMDQRAPWFLFKQGGVSAEEAAKDLviiLEVMRVIAVALSPIAPCLSLRIYSQL-GYS-E 548
|
....*....
gi 1278124880 620 EPFESVHLS 628
Cdd:PLN02224 549 DQFNSITWS 557
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
582-613 |
5.09e-05 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 43.36 E-value: 5.09e-05
10 20 30
....*....|....*....|....*....|..
gi 1278124880 582 AAYQTLYESLKIIAKLLSPFAPFFAEELYQNL 613
Cdd:cd07958 86 QHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
432-483 |
6.80e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 43.17 E-value: 6.80e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1278124880 432 GQKMSKSKGNTVDPFTLFDKYGADATR-WYLTVNnppWRPTL-FSEDDLAETQR 483
Cdd:COG0215 263 GEKMSKSLGNFFTVRDLLKKYDPEVLRfFLLSAH---YRSPLdFSEEALEEAEK 313
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
425-441 |
4.98e-03 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 40.57 E-value: 4.98e-03
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
425-489 |
6.75e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 39.55 E-value: 6.75e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1278124880 425 DLILDKKGQKMSKSKGNTVDPFTLFDKYGADATRWYLTVNNPPWRPTLFSE------DDLAETQRKFFGTL 489
Cdd:pfam01921 270 ELILLKGGGKMSSSKGNVITPEDWLEYAPPESLRFLMFRTKPKKAKDLDFDviprlvDEYDRLERIYFAKQ 340
|
|
| |
